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MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVRRYGKAFTANILMYGRVVVVADPQLAR QVFTSSPEELGNIQPNLSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQ GQAFATLPSMMHITLNAILRAIFGAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWR RQYDTVIDKLIEAERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLGWAFE RLSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGEWVIPRGYSIIINIAQI HGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLETTTAAGER SHGRGVAFTPKDGGRVVMRRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0136 | cyp138 | - | 100% (441) | PROBABLE CYTOCHROME P450 138 CYP138 |
| M. tuberculosis H37Rv | Rv0568 | cyp135B1 | 2e-77 | 38.24% (442) | cytochrome P450 135B1 |
| M. tuberculosis H37Rv | Rv3685c | cyp137 | 9e-70 | 35.21% (443) | cytochrome P450 137 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0141 | cyp138 | 0.0 | 100.00% (441) | cytochrome P450 138 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 1e-174 | 67.99% (428) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 9e-14 | 24.17% (331) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1427c | - | 1e-160 | 62.59% (441) | putative cytochrome P450 |
| M. marinum M | MMAR_0346 | cyp138A3 | 0.0 | 75.74% (441) | cytochrome P450 138A3 Cyp138A3 |
| M. avium 104 | MAV_5160 | - | 0.0 | 77.32% (441) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6478 | - | 1e-168 | 66.28% (427) | putative cytochrome P450 135B1 |
| M. thermoresistible (build 8) | TH_0082 | - | 1e-174 | 65.99% (444) | putative cytochrome P450 135B1 |
| M. ulcerans Agy99 | MUL_0473 | cyp51B1 | 5e-28 | 26.85% (406) | cytochrome P450 51B1 Cyp51B1 |
| M. vanbaalenii PYR-1 | Mvan_5712 | - | 0.0 | 70.18% (436) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0136|M.tuberculosis_H37Rv ---------MSEVVTAAPAPPVVR--LPPAVRGPKLFQGLAFVVSRRR--
Mb0141|M.bovis_AF2122/97 ---------MSEVVTAAPAPPVVR--LPPAVRGPKLFQGLAFVVSRRR--
MMAR_0346|M.marinum_M ---------MNQAISDAPAVPAVK--MAQATRIPKLLQGLAFATSRRR--
MAV_5160|M.avium_104 ---------MSEVATAP--LAAVH--LPPAVRGPKLLQGIGFAVSRRT--
Mflv_1104|M.gilvum_PYR-GCK ----------------------MR--LPPTPRIPRFLQGLGFSLSRQW--
Mvan_5712|M.vanbaalenii_PYR-1 MSEATIAAHRSTADAESAPPRPVR--LPPTPRIPKLLQGLGFSFSRQW--
MSMEG_6478|M.smegmatis_MC2_155 --------MTATVERPESAIRAAQ--LPPVLPLPKTVQGLAFSVARRW--
TH_0082|M.thermoresistible__bu ------MTEATIAPDVDHAVRSQK--LPPAVPLPKSLQGIAFIASRRW--
MAB_1427c|M.abscessus_ATCC_199 -----MEGDVTEISTIDRAADVPKPIAPPLVTLPKLAQGIAFVASRRW--
MUL_0473|M.ulcerans_Agy99 -------------MTTAIVPRVSG-------GEEEHGHLEEFRTDPIG--
MLBr_02088|M.leprae_Br4923 -----MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPG
. :
Rv0136|M.tuberculosis_H37Rv ------LLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELG
Mb0141|M.bovis_AF2122/97 ------LLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELG
MMAR_0346|M.marinum_M ------MMDWLSRRNGDVFALNVPIYGHMVVVNDPQLAKQVFTASPEDLG
MAV_5160|M.avium_104 ------MMRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIFTTSPDELG
Mflv_1104|M.gilvum_PYR-GCK ------TVAQVVRRYGDVFTMTLPVFGKTVLVTDPALAKQLFMANTDDVG
Mvan_5712|M.vanbaalenii_PYR-1 ------TVAQIVRRYGDVFSMTLPVFGPTVMVADPALAKQLFMANTDDVG
MSMEG_6478|M.smegmatis_MC2_155 ------VVKQAARRYGDVVTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVG
TH_0082|M.thermoresistible__bu ------TLTTATRRYGDVFRLNIPVFGRTVVVSDPVLAKQVFSANPDDVG
MAB_1427c|M.abscessus_ATCC_199 ------TTSRLAKKYGKVYTINIPKFGYTVVVADPDLTREVFTTSTEILG
MUL_0473|M.ulcerans_Agy99 ------LMQRVRDECGDVGWFQLANK-HVVLLSGAKANEFFFRSSDEELD
MLBr_02088|M.leprae_Br4923 TRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKA
* : . . :
Rv0136|M.tuberculosis_H37Rv NIQPN------LSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYET
Mb0141|M.bovis_AF2122/97 NIQPN------LSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYET
MMAR_0346|M.marinum_M NIQPN------LSRMFGSGSVFGLDGDDHRRRRRLLAPPFHGKSMKNYEI
MAV_5160|M.avium_104 NIQPN------LSRLFGSGSVFGLEGDDHRRRRRLLAPPFHGKSMKNYES
Mflv_1104|M.gilvum_PYR-GCK NIQPN------LSRVLGSGSVFALDGTDHRLRRKLLTPPFHGKSIKNYER
Mvan_5712|M.vanbaalenii_PYR-1 NIQPN------LSRVLGSGSVFALDGGDHRKRRKLLTPPFHGKSIKNYET
MSMEG_6478|M.smegmatis_MC2_155 NVQPN------LSRMLGPGSVFALDGTDHRRRRKLLTPPFHGRSIKNYER
TH_0082|M.thermoresistible__bu NIQPN------LSRVLGPGSVFALDGAEHRRRRKLLTPPFHGKSIKNYEK
MAB_1427c|M.abscessus_ATCC_199 NIQPN------LSQQLGPGSVFALERNEHRHRRKLLAPKFHGKAMVQYEQ
MUL_0473|M.ulcerans_Agy99 QAEAYPF----MTPIFGKGVVFDAS--PERRKEMLHNSALRGEHMKGHAT
MLBr_02088|M.leprae_Br4923 TLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEG
. : . .: . . . * : . :
Rv0136|M.tuberculosis_H37Rv IIEEETLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGSELDELRR
Mb0141|M.bovis_AF2122/97 IIEEETLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGSELDELRR
MMAR_0346|M.marinum_M IIEQETLRETANWPEGQLFPTLPSMMRITLNAILRAVFGADGAELDELRR
MAV_5160|M.avium_104 IIEEETLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEGAELDELRR
Mflv_1104|M.gilvum_PYR-GCK IFEEETLREAASWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRR
Mvan_5712|M.vanbaalenii_PYR-1 IFEEETLREAANWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRR
MSMEG_6478|M.smegmatis_MC2_155 IFEEETLREAASWPDGQEFRTLEPMMRITLNVILRAVFGADGEQLDELRR
TH_0082|M.thermoresistible__bu IFEEETLAEAANWPEGREFPTLEPMMRITLNAILRAVFGAEGEHLDELRR
MAB_1427c|M.abscessus_ATCC_199 IIEEETLRECATWPEGQQFETMEPMMRITLNAILRAVFGADGAELDVLRR
MUL_0473|M.ulcerans_Agy99 TIEREVHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFR--NQLDS
MLBr_02088|M.leprae_Br4923 DIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
: . : : : . ::*. :
Rv0136|M.tuberculosis_H37Rv LIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVIDKLIEAER
Mb0141|M.bovis_AF2122/97 LIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVIDKLIEAER
MMAR_0346|M.marinum_M IIPPWTTLGSRLASMPKPKRRYGRFSPWGRLAEYRRQYDVIIDRLIDQER
MAV_5160|M.avium_104 LIPPWVTLGSRLAALPKPQR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQ
Mflv_1104|M.gilvum_PYR-GCK IIPPWVTLGSRLAVLPTPHRTYGRFSPWGRLARYRRRYDEVIGRLIDAVQ
Mvan_5712|M.vanbaalenii_PYR-1 IIPPWVTLGSRLAVLPTPHRTYGRFSPWGRLAAYRRQYDDVIGRLIDAVQ
MSMEG_6478|M.smegmatis_MC2_155 IIPPWVTLGSRLAVLPTPKRNYGRLTPWGRLAAYRAEYDDVVDRLIDRVE
TH_0082|M.thermoresistible__bu IIPPWVTLGSRVATLPTPSRNYGRFSPWGRLAAYRRCYDEVIGRLIDKVQ
MAB_1427c|M.abscessus_ATCC_199 LIPPWVVLASLTTRIPQPKRNYGRFSPWGRLKTYRAHYDAVIGSLIEKAL
MUL_0473|M.ulcerans_Agy99 RFAHFCHELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQRV
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITIT--GEPPEATEERLRAGVWLRDY---LEQLVKCRR
. . : : ::
Rv0136|M.tuberculosis_H37Rv ADPNFADRT-DVLALMLRSTYDDGS-IMSRKDIGDELLTLLAAGHETTAA
Mb0141|M.bovis_AF2122/97 ADPNFADRT-DVLALMLRSTYDDGS-IMSRKDIGDELLTLLAAGHETTAA
MMAR_0346|M.marinum_M SDPNFSDRT-DVLALMLRSTYDDGS-RMSRKDIGDELLALLAAGHETTAS
MAV_5160|M.avium_104 ADPNFAERT-DVLALLLRSTYDDGA-AMSHKEIGDELLTLLAAGHETTAS
Mflv_1104|M.gilvum_PYR-GCK ADPNFESRD-DVLALLLRSTYEDGS-SMSRQDIGDELLTLLAAGHETTAA
Mvan_5712|M.vanbaalenii_PYR-1 ADPDFDTRD-DILALLLRSTYEDGS-TMSRQDIGDELLTLLAAGHETTAA
MSMEG_6478|M.smegmatis_MC2_155 ADPDFDQRD-DILALLLRSAYEDGS-SMSRKDIGDELLTLLAAGHETTAS
TH_0082|M.thermoresistible__bu ADPHFEERD-DVLALLLRSTYEDGT-AMTRQDIADELLTLLAAGHETTAS
MAB_1427c|M.abscessus_ATCC_199 AAPDFEDRT-DILALLLRSTYDDGT-TMSRSDVSDELLTLLAAGHETTAT
MUL_0473|M.ulcerans_Agy99 ANPPTDKRDRDMLDVLVSITDEQGNPRFCTDEVTGMFISLMFAGHHTSSG
MLBr_02088|M.leprae_Br4923 GTPGE-----DLISRLIELD-ESGD-QLTEEEIIATCGLLLVAGHETTVN
. * *:: :: :.* : .:: *: ***.*:
Rv0136|M.tuberculosis_H37Rv TLGWAFERLSRHPDVLAALVEEVDN---GGHELRQAAILEVQRARTVIDF
Mb0141|M.bovis_AF2122/97 TLGWAFERLSRHPDVLAALVEEVDN---GGHELRQAAILEVQRARTVIDF
MMAR_0346|M.marinum_M TLSWAFERVTRHPELLAALVAEAED---AGGELRQATILEVQRARTVIDF
MAV_5160|M.avium_104 TLAWAFERISRHPELLARLVEEADN---GGNELRQAAILEVQRARTVIDF
Mflv_1104|M.gilvum_PYR-GCK TLGWVFERISRHPDVLARLQAEADT---DGNEYRQAVILETQRVRTVIDF
Mvan_5712|M.vanbaalenii_PYR-1 TLGWAFERISRHPEVLAKLVAEAET---DGNEYRQATILEIQRSRTVIDF
MSMEG_6478|M.smegmatis_MC2_155 TLGWAFERISRHPGVLEKLVAEAAT---DDNEYRQAAIAEVQRVRTVIDF
TH_0082|M.thermoresistible__bu TMGWVFERITRHPEVLARLAAEADT---DENTYRQATILEVQRARTVIDF
MAB_1427c|M.abscessus_ATCC_199 TLAWAFERITRHPEVLSRLAEEAQG---DSNEYRQATILEVQRSRPVIDF
MUL_0473|M.ulcerans_Agy99 TSAWTLIELLRHPDAYAAVIDELDELYADGQLVSFHALRQIPRLENVLKE
MLBr_02088|M.leprae_Br4923 LIANAVLAMLRNPSQWKALSSNPQR--------APLVVEETLRYDPAIHL
. .. : *:* : : .: : * .:.
Rv0136|M.tuberculosis_H37Rv AAR---------RVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPD
Mb0141|M.bovis_AF2122/97 AAR---------RVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPD
MMAR_0346|M.marinum_M AAR---------HVYAPQYQLGQWMIPRGQSILVNIAQMHANPDIFPDPQ
MAV_5160|M.avium_104 AGR---------HVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPR
Mflv_1104|M.gilvum_PYR-GCK AGR---------HVYAPTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPE
Mvan_5712|M.vanbaalenii_PYR-1 AGR---------HVYAPTFELGEWVIPQGYSIVVAIGQVHKRAQDFDDPD
MSMEG_6478|M.smegmatis_MC2_155 SGR---------HVYAPSFQLGQWTIPRGYSIMVAIAHIQEREEEFSDPH
TH_0082|M.thermoresistible__bu SGR---------HVYAPTLELGDWVIPRGYSIVVSISQLHERSAEFPRPD
MAB_1427c|M.abscessus_ATCC_199 AGR---------HVLAPHVDIGPYRIPQGHSVVVSINLMHDDPVAFPCPE
MUL_0473|M.ulcerans_Agy99 TLRLHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPD
MLBr_02088|M.leprae_Br4923 IGR----------VAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPD
* * : : .* : : : *
Rv0136|M.tuberculosis_H37Rv RFDPQRYIGSKPS----PFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLR
Mb0141|M.bovis_AF2122/97 RFDPQRYIGSKPS----PFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLR
MMAR_0346|M.marinum_M RFDPQRFIGGRPS----TFGWIPFGGGTRRCVGAAFANMEMDVVLRTVLR
MAV_5160|M.avium_104 RFDPQRFIDNKPS----ALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLR
Mflv_1104|M.gilvum_PYR-GCK DFDPQRFVGQRPS----TLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFR
Mvan_5712|M.vanbaalenii_PYR-1 RFDPQRYIGQRPP----TFAHIPFGGGTRRCVGAAFANVEMDIVLRTVLR
MSMEG_6478|M.smegmatis_MC2_155 RFDPQRFVGNRP-----GLGWLPYGGGTRRCVGAVFANIEMDVVLRTILR
TH_0082|M.thermoresistible__bu EFDPDRFVGSRPP----MFAWLPYGGGTRRCVGAVFANVEMDVVLRTVLR
MAB_1427c|M.abscessus_ATCC_199 RFDPERFMGAKP-----GNSWVPYGGGTRRCVGAAFANMEMDIVLRTVLR
MUL_0473|M.ulcerans_Agy99 EFVPERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLR
MLBr_02088|M.leprae_Br4923 EFDPDRP----------SSRHLAFAVGSHFCLGAALARLEATVTLSAISA
* *:* :.:. * : *:**.:* :: : .:
Rv0136|M.tuberculosis_H37Rv HFTLETTTAAGERSHGRG-VAFTPKDGGRVVMRRR--------
Mb0141|M.bovis_AF2122/97 HFTLETTTAAGERSHGRG-VAFTPKDGGRVVMRRR--------
MMAR_0346|M.marinum_M NFTIEPTTAAGERLFCRG-VAYTPKNGGRIVVHRR--------
MAV_5160|M.avium_104 HFTIETTDAPDEPWHCRG-VAFTPKHGGRIVVHRR--------
Mflv_1104|M.gilvum_PYR-GCK HFTIETTTAPGEKMHSRG-VAYTPDDGGRVVMRRR--------
Mvan_5712|M.vanbaalenii_PYR-1 HFVIETTAAPGEKMHSRG-VAYTPKDGGRVVMRRR--------
MSMEG_6478|M.smegmatis_MC2_155 HFVIETTTAPDEKVHPRG-VAYTPASGGRVVMRRRREPLGA--
TH_0082|M.thermoresistible__bu HFTLETTTAPDEKVHSRG-VAYTPKDGGRVTLHRR--------
MAB_1427c|M.abscessus_ATCC_199 HFTIETTTAPDEKWHSRG-VASCPKNNGRVTVRRR--------
MUL_0473|M.ulcerans_Agy99 EYEFEMAQPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH
MLBr_02088|M.leprae_Br4923 RFP--QVQLAGELVYKPN-VAMRGMSALPVQV-----------
.: . ... . :. :