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VRLPPTPRIPRFLQGLGFSLSRQWTVAQVVRRYGDVFTMTLPVFGKTVLVTDPALAKQLFMANTDDVGNI QPNLSRVLGSGSVFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEETLREAASWPEGQPFETLEPMMRI TLNAILRAVFGADGAHLDELRRIIPPWVTLGSRLAVLPTPHRTYGRFSPWGRLARYRRRYDEVIGRLIDA VQADPNFESRDDVLALLLRSTYEDGSSMSRQDIGDELLTLLAAGHETTAATLGWVFERISRHPDVLARLQ AEADTDGNEYRQAVILETQRVRTVIDFAGRHVYAPTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPEDF DPQRFVGQRPSTLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFRHFTIETTTAPGEKMHSRGVAYTPDDG GRVVMRRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1104 | - | - | 100% (428) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_3376 | - | e-121 | 52.33% (430) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4315 | - | 4e-23 | 24.53% (424) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0141 | cyp138 | 1e-174 | 67.99% (428) | cytochrome P450 138 |
| M. tuberculosis H37Rv | Rv0136 | cyp138 | 1e-174 | 67.99% (428) | cytochrome P450 138 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-11 | 23.85% (327) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1427c | - | 1e-160 | 64.00% (425) | putative cytochrome P450 |
| M. marinum M | MMAR_0346 | cyp138A3 | 1e-172 | 67.99% (428) | cytochrome P450 138A3 Cyp138A3 |
| M. avium 104 | MAV_5160 | - | 1e-176 | 69.39% (428) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6478 | - | 0.0 | 75.88% (427) | putative cytochrome P450 135B1 |
| M. thermoresistible (build 8) | TH_0082 | - | 0.0 | 77.05% (427) | putative cytochrome P450 135B1 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 6e-24 | 24.59% (362) | cytochrome P450 136A2 Cyp136A2 |
| M. vanbaalenii PYR-1 | Mvan_5712 | - | 0.0 | 89.49% (428) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0141|M.bovis_AF2122/97 ---------------------------------------MSEVVTAAPAP
Rv0136|M.tuberculosis_H37Rv ---------------------------------------MSEVVTAAPAP
MMAR_0346|M.marinum_M ---------------------------------------MNQAISDAPAV
MAV_5160|M.avium_104 ---------------------------------------MSEVATAP--L
Mflv_1104|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5712|M.vanbaalenii_PYR-1 ------------------------------MSEATIAAHRSTADAESAPP
MSMEG_6478|M.smegmatis_MC2_155 --------------------------------------MTATVERPESAI
TH_0082|M.thermoresistible__bu ------------------------------------MTEATIAPDVDHAV
MAB_1427c|M.abscessus_ATCC_199 -----------------------------------MEGDVTEISTIDRAA
MUL_3402|M.ulcerans_Agy99 MATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPPP
MLBr_02088|M.leprae_Br4923 -----------------------------------MRTCVPTRTCVYAFI
Mb0141|M.bovis_AF2122/97 PVVR--LPPAVRGPKLFQGLAFVV--------SRRRLLGRFVRRYGKAFT
Rv0136|M.tuberculosis_H37Rv PVVR--LPPAVRGPKLFQGLAFVV--------SRRRLLGRFVRRYGKAFT
MMAR_0346|M.marinum_M PAVK--MAQATRIPKLLQGLAFAT--------SRRRMMDWLSRRNGDVFA
MAV_5160|M.avium_104 AAVH--LPPAVRGPKLLQGIGFAV--------SRRTMMRRLSRRYGNVFT
Mflv_1104|M.gilvum_PYR-GCK --MR--LPPTPRIPRFLQGLGFSL--------SRQWTVAQVVRRYGDVFT
Mvan_5712|M.vanbaalenii_PYR-1 RPVR--LPPTPRIPKLLQGLGFSF--------SRQWTVAQIVRRYGDVFS
MSMEG_6478|M.smegmatis_MC2_155 RAAQ--LPPVLPLPKTVQGLAFSV--------ARRWVVKQAARRYGDVVT
TH_0082|M.thermoresistible__bu RSQK--LPPAVPLPKSLQGIAFIA--------SRRWTLTTATRRYGDVFR
MAB_1427c|M.abscessus_ATCC_199 DVPKPIAPPLVTLPKLAQGIAFVA--------SRRWTTSRLAKKYGKVYT
MUL_3402|M.ulcerans_Agy99 GSDLKPVVGDAGLPILGHLIEMLR--------GGPDYLMFLYRTKGPVVF
MLBr_02088|M.leprae_Br4923 EYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADPFPVYRALIDYGPMQL
* . : . *
Mb0141|M.bovis_AF2122/97 ANILMYGRVVVVADPQLARQVFTSSPEELGN--IQPNLS----RMFGSGS
Rv0136|M.tuberculosis_H37Rv ANILMYGRVVVVADPQLARQVFTSSPEELGN--IQPNLS----RMFGSGS
MMAR_0346|M.marinum_M LNVPIYGHMVVVNDPQLAKQVFTASPEDLGN--IQPNLS----RMFGSGS
MAV_5160|M.avium_104 LRLPMWGPVVMVSDPQLAKQIFTTSPDELGN--IQPNLS----RLFGSGS
Mflv_1104|M.gilvum_PYR-GCK MTLPVFGKTVLVTDPALAKQLFMANTDDVGN--IQPNLS----RVLGSGS
Mvan_5712|M.vanbaalenii_PYR-1 MTLPVFGPTVMVADPALAKQLFMANTDDVGN--IQPNLS----RVLGSGS
MSMEG_6478|M.smegmatis_MC2_155 LDIPVFGRTVLVTEPQLAKQVYAAHPDDVGN--VQPNLS----RMLGPGS
TH_0082|M.thermoresistible__bu LNIPVFGRTVVVSDPVLAKQVFSANPDDVGN--IQPNLS----RVLGPGS
MAB_1427c|M.abscessus_ATCC_199 INIPKFGYTVVVADPDLTREVFTTSTEILGN--IQPNLS----QQLGPGS
MUL_3402|M.ulcerans_Agy99 GDSPVLSAVVALG-PDAAQVIYSNRNKDYSQQGWVPVIG----PFFRRG-
MLBr_02088|M.leprae_Br4923 PGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQAIAAGAEPRPFYASS
: . . . : .
Mb0141|M.bovis_AF2122/97 VFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEETLRETA-NWPQGQA-
Rv0136|M.tuberculosis_H37Rv VFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEETLRETA-NWPQGQA-
MMAR_0346|M.marinum_M VFGLDGDDHRRRRRLLAPPFHGKSMKNYEIIIEQETLRETA-NWPEGQL-
MAV_5160|M.avium_104 VFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEETLRETA-GWPEGES-
Mflv_1104|M.gilvum_PYR-GCK VFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEETLREAA-SWPEGQP-
Mvan_5712|M.vanbaalenii_PYR-1 VFALDGGDHRKRRKLLTPPFHGKSIKNYETIFEEETLREAA-NWPEGQP-
MSMEG_6478|M.smegmatis_MC2_155 VFALDGTDHRRRRKLLTPPFHGRSIKNYERIFEEETLREAA-SWPDGQE-
TH_0082|M.thermoresistible__bu VFALDGAEHRRRRKLLTPPFHGKSIKNYEKIFEEETLAEAA-NWPEGRE-
MAB_1427c|M.abscessus_ATCC_199 VFALERNEHRHRRKLLAPKFHGKAMVQYEQIIEEETLRECA-TWPEGQQ-
MUL_3402|M.ulcerans_Agy99 LMLLDFEEHMFHRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDAR
MLBr_02088|M.leprae_Br4923 FMFLDPPDHTRLRKLVSKAFAPKVVQALEG--DIAALVDSLLDKGAAAGQ
.: *: :* *::: * : : :
Mb0141|M.bovis_AF2122/97 FATLPSMMHITLNAILRAIFGAGGSELDELRRLIPPWVTLGSRLAALPKP
Rv0136|M.tuberculosis_H37Rv FATLPSMMHITLNAILRAIFGAGGSELDELRRLIPPWVTLGSRLAALPKP
MMAR_0346|M.marinum_M FPTLPSMMRITLNAILRAVFGADGAELDELRRIIPPWTTLGSRLASMPKP
MAV_5160|M.avium_104 FPTLPPMMRITLNAILRAVFGAEGAELDELRRLIPPWVTLGSRLAALPKP
Mflv_1104|M.gilvum_PYR-GCK FETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPWVTLGSRLAVLPTP
Mvan_5712|M.vanbaalenii_PYR-1 FETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPWVTLGSRLAVLPTP
MSMEG_6478|M.smegmatis_MC2_155 FRTLEPMMRITLNVILRAVFGADGEQLDELRRIIPPWVTLGSRLAVLPTP
TH_0082|M.thermoresistible__bu FPTLEPMMRITLNAILRAVFGAEGEHLDELRRIIPPWVTLGSRVATLPTP
MAB_1427c|M.abscessus_ATCC_199 FETMEPMMRITLNAILRAVFGADGAELDVLRRLIPPWVVLASLTTRIPQP
MUL_3402|M.ulcerans_Agy99 FLLYPAMKKLTLDIASMVFMGHEPGTDHELVTKVNRAFTTTTRAG-NAVI
MLBr_02088|M.leprae_Br4923 FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGE
* : .:* : .
Mb0141|M.bovis_AF2122/97 KRDYGRLSPWGRLAEWRRQYDTVIDKLIEAERADPNFADRTDVLALMLRS
Rv0136|M.tuberculosis_H37Rv KRDYGRLSPWGRLAEWRRQYDTVIDKLIEAERADPNFADRTDVLALMLRS
MMAR_0346|M.marinum_M KRRYGRFSPWGRLAEYRRQYDVIIDRLIDQERSDPNFSDRTDVLALMLRS
MAV_5160|M.avium_104 QR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADPNFAERTDVLALLLRS
Mflv_1104|M.gilvum_PYR-GCK HRTYGRFSPWGRLARYRRRYDEVIGRLIDAVQADPNFESRDDVLALLLRS
Mvan_5712|M.vanbaalenii_PYR-1 HRTYGRFSPWGRLAAYRRQYDDVIGRLIDAVQADPDFDTRDDILALLLRS
MSMEG_6478|M.smegmatis_MC2_155 KRNYGRLTPWGRLAAYRAEYDDVVDRLIDRVEADPDFDQRDDILALLLRS
TH_0082|M.thermoresistible__bu SRNYGRFSPWGRLAAYRRCYDEVIGRLIDKVQADPHFEERDDVLALLLRS
MAB_1427c|M.abscessus_ATCC_199 KRNYGRFSPWGRLKTYRAHYDAVIGSLIEKALAAPDFEDRTDILALLLRS
MUL_3402|M.ulcerans_Agy99 RTSVPPFTWWRGIRAR-----QLLENYFAARVTERRGQEGNDLLTVLCHT
MLBr_02088|M.leprae_Br4923 PPEATEERLRAGVWLR-----DYLEQLVKCRRGTP----GEDLISRLIEL
: : . *::: : .
Mb0141|M.bovis_AF2122/97 TYDDGSIMSRKDIGDELLTLLAAGHETTAATLGWAFERLSRHPDVLAALV
Rv0136|M.tuberculosis_H37Rv TYDDGSIMSRKDIGDELLTLLAAGHETTAATLGWAFERLSRHPDVLAALV
MMAR_0346|M.marinum_M TYDDGSRMSRKDIGDELLALLAAGHETTASTLSWAFERVTRHPELLAALV
MAV_5160|M.avium_104 TYDDGAAMSHKEIGDELLTLLAAGHETTASTLAWAFERISRHPELLARLV
Mflv_1104|M.gilvum_PYR-GCK TYEDGSSMSRQDIGDELLTLLAAGHETTAATLGWVFERISRHPDVLARLQ
Mvan_5712|M.vanbaalenii_PYR-1 TYEDGSTMSRQDIGDELLTLLAAGHETTAATLGWAFERISRHPEVLAKLV
MSMEG_6478|M.smegmatis_MC2_155 AYEDGSSMSRKDIGDELLTLLAAGHETTASTLGWAFERISRHPGVLEKLV
TH_0082|M.thermoresistible__bu TYEDGTAMTRQDIADELLTLLAAGHETTASTMGWVFERITRHPEVLARLA
MAB_1427c|M.abscessus_ATCC_199 TYDDGTTMSRSDVSDELLTLLAAGHETTATTLAWAFERITRHPEVLSRLA
MUL_3402|M.ulcerans_Agy99 ADEDGNRFSDQDIVNHMIFLMMAAHDTSTSTATTMAYHLAAHPEWQQRCR
MLBr_02088|M.leprae_Br4923 D-ESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALS
:.* :: .:: *: *.*:*:. : :*
Mb0141|M.bovis_AF2122/97 EEVDNGGH-----------ELRQAAILEVQRARTVIDFAARRVNPPVYQL
Rv0136|M.tuberculosis_H37Rv EEVDNGGH-----------ELRQAAILEVQRARTVIDFAARRVNPPVYQL
MMAR_0346|M.marinum_M AEAEDAGG-----------ELRQATILEVQRARTVIDFAARHVYAPQYQL
MAV_5160|M.avium_104 EEADNGGN-----------ELRQAAILEVQRARTVIDFAGRHVYPDVYRL
Mflv_1104|M.gilvum_PYR-GCK AEADTDGN-----------EYRQAVILETQRVRTVIDFAGRHVYAPTFEL
Mvan_5712|M.vanbaalenii_PYR-1 AEAETDGN-----------EYRQATILEIQRSRTVIDFAGRHVYAPTFEL
MSMEG_6478|M.smegmatis_MC2_155 AEAATDDN-----------EYRQAAIAEVQRVRTVIDFSGRHVYAPSFQL
TH_0082|M.thermoresistible__bu AEADTDEN-----------TYRQATILEVQRARTVIDFSGRHVYAPTLEL
MAB_1427c|M.abscessus_ATCC_199 EEAQGDSN-----------EYRQATILEVQRSRPVIDFAGRHVLAPHVDI
MUL_3402|M.ulcerans_Agy99 DESDRLGDGPLDIEALEKLESLDLVMNESIRLVTPVQWAMRQTVRDTELL
MLBr_02088|M.leprae_Br4923 SNP----------------QRAPLVVEETLRYDPAIHLIGR-VAAKDMTI
: .: * * . :. * . :
Mb0141|M.bovis_AF2122/97 GEWVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIG----SKPSPFAW
Rv0136|M.tuberculosis_H37Rv GEWVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIG----SKPSPFAW
MMAR_0346|M.marinum_M GQWMIPRGQSILVNIAQMHANPDIFPDPQRFDPQRFIG----GRPSTFGW
MAV_5160|M.avium_104 GEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFDPQRFID----NKPSALSW
Mflv_1104|M.gilvum_PYR-GCK GEWIIPQGYSIVVAIGQVHHREQDYLDPEDFDPQRFVG----QRPSTLSH
Mvan_5712|M.vanbaalenii_PYR-1 GEWVIPQGYSIVVAIGQVHKRAQDFDDPDRFDPQRYIG----QRPPTFAH
MSMEG_6478|M.smegmatis_MC2_155 GQWTIPRGYSIMVAIAHIQEREEEFSDPHRFDPQRFVG----NRP-GLGW
TH_0082|M.thermoresistible__bu GDWVIPRGYSIVVSISQLHERSAEFPRPDEFDPDRFVG----SRPPMFAW
MAB_1427c|M.abscessus_ATCC_199 GPYRIPQGHSVVVSINLMHDDPVAFPCPERFDPERFMG----AKP-GNSW
MUL_3402|M.ulcerans_Agy99 G-YYLPKGTNVIAYPGMNHRLPEFWTDPMTFDPDRFAEPRNEHKRHRYAF
MLBr_02088|M.leprae_Br4923 GQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS----------RH
* :..* .:: : : * ***:*
Mb0141|M.bovis_AF2122/97 IPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAF
Rv0136|M.tuberculosis_H37Rv IPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAF
MMAR_0346|M.marinum_M IPFGGGTRRCVGAAFANMEMDVVLRTVLRNFTIEPTTAAGERLFCRGVAY
MAV_5160|M.avium_104 IPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTIETTDAPDEPWHCRGVAF
Mflv_1104|M.gilvum_PYR-GCK IPFGGGTRRCVGAVFANVEMDIVLRTVFRHFTIETTTAPGEKMHSRGVAY
Mvan_5712|M.vanbaalenii_PYR-1 IPFGGGTRRCVGAAFANVEMDIVLRTVLRHFVIETTAAPGEKMHSRGVAY
MSMEG_6478|M.smegmatis_MC2_155 LPYGGGTRRCVGAVFANIEMDVVLRTILRHFVIETTTAPDEKVHPRGVAY
TH_0082|M.thermoresistible__bu LPYGGGTRRCVGAVFANVEMDVVLRTVLRHFTLETTTAPDEKVHSRGVAY
MAB_1427c|M.abscessus_ATCC_199 VPYGGGTRRCVGAAFANMEMDIVLRTVLRHFTIETTTAPDEKWHSRGVAS
MUL_3402|M.ulcerans_Agy99 TPFGGGAHKCLGMVFGQLEIKTILHRLLRRYRLELARPDYRACWDYGGMP
MLBr_02088|M.leprae_Br4923 LAFAVGSHFCLGAALARLEATVTLSAISARFPQVQLAG--ELVYKPNVAM
.:. *:: *:* .:..:* * : .: . .
Mb0141|M.bovis_AF2122/97 TPKDGGRVVMRRR------
Rv0136|M.tuberculosis_H37Rv TPKDGGRVVMRRR------
MMAR_0346|M.marinum_M TPKNGGRIVVHRR------
MAV_5160|M.avium_104 TPKHGGRIVVHRR------
Mflv_1104|M.gilvum_PYR-GCK TPDDGGRVVMRRR------
Mvan_5712|M.vanbaalenii_PYR-1 TPKDGGRVVMRRR------
MSMEG_6478|M.smegmatis_MC2_155 TPASGGRVVMRRRREPLGA
TH_0082|M.thermoresistible__bu TPKDGGRVTLHRR------
MAB_1427c|M.abscessus_ATCC_199 CPKNNGRVTVRRR------
MUL_3402|M.ulcerans_Agy99 VPKDGMPIVLRPL------
MLBr_02088|M.leprae_Br4923 RGMSALPVQV---------
: :