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PASAPSARTPPALRRPPGLPAPRRLRTVFAAAYAVAYLVGGERRMLRLIRRYGPIMTMPILSLGDVAIVS DPALVKEVFTAPPDVLLGGEGVGPAAAIYGAGSMFVQEEPEHLRRRKLLTPPLHGTALGRYVPIIEESTR AAMRDWPVDRPFELLGAARALMLDVIVKVIFGVDDPDEVRRLGRPFERLLDLGVSEQLTVRYALRRAGAL RVWPQRARAYREIEDVVMPLIAQRRSDLGRTEQRDILGLLISARGDDGEQLSDQEIRDDLITLMLAGHET TATTLAWVFDLLLHHPDALRRVQEEAEGGTETFTTAVINETLRVRPPAPFTARVAARPFRLGGYLIDPGT RIVVHMIAINRNPDVYEQPNRFRPERFLGTRPQTYAWVPFGGGAKRCLGAAFSMRELVTVLHVLLREGQF TAVDEAPERIVRRSIMLAPRHGTRVRFRPRLQESV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5175 | cyp137A2 | - | 100% (456) | cytochrome P450 137A2 Cyp137A2 |
| M. marinum M | MMAR_0346 | cyp138A3 | 3e-72 | 34.62% (439) | cytochrome P450 138A3 Cyp138A3 |
| M. marinum M | MMAR_0938 | cyp135B4 | 2e-67 | 32.36% (445) | cytochrome P450 135B4 Cyp135B4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3710c | cyp137 | 0.0 | 82.95% (440) | cytochrome P450 137 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 1e-68 | 35.60% (441) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3685c | cyp137 | 0.0 | 83.18% (440) | cytochrome P450 137 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-20 | 27.41% (343) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 1e-69 | 34.01% (441) | cytochrome P450 |
| M. avium 104 | MAV_5160 | - | 6e-76 | 36.91% (447) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6478 | - | 4e-66 | 35.81% (444) | putative cytochrome P450 135B1 |
| M. thermoresistible (build 8) | TH_0136 | - | 1e-147 | 59.95% (442) | PROBABLE CYTOCHROME P450 137 CYP137 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 7e-31 | 29.17% (336) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0675 | - | 1e-154 | 61.70% (436) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3710c|M.bovis_AF2122/97 MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGLPAPRGF
Rv3685c|M.tuberculosis_H37Rv MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGLPAPRGF
MMAR_5175|M.marinum_M ---MPASAPSARTPP---------------------ALRRPPGLPAPRRL
TH_0136|M.thermoresistible__bu --------------------------------------VRPPSLPAPAPL
Mvan_0675|M.vanbaalenii_PYR-1 --------------------------------------MRPPSLPAPPPL
Mflv_1104|M.gilvum_PYR-GCK --------------------------------------------MRLPPT
MSMEG_6478|M.smegmatis_MC2_155 ------------------------------MTATVERPESAIRAAQLPPV
MAV_5160|M.avium_104 ---------------------------------MSEVATAPLAAVHLPPA
MAB_4693|M.abscessus_ATCC_1997 --------------------------------------MSKTAKIALPPG
MUL_0604|M.ulcerans_Agy99 -------------------------------------MVDPPDIRSLPLA
MLBr_02088|M.leprae_Br4923 ------------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLV
Mb3710c|M.bovis_AF2122/97 RAAFAAAYAVAYLAGGERR-MLRLIRRYG----PIMTMPILSLGDVAIVS
Rv3685c|M.tuberculosis_H37Rv RAAFAAAYAVAYLAGGERR-MLRLIRRYG----PIMTMPILSLGDVAIVS
MMAR_5175|M.marinum_M RTVFAAAYAVAYLVGGERR-MLRLIRRYG----PIMTMPILSLGDVAIVS
TH_0136|M.thermoresistible__bu SAVFGAGYAAAYAVGGNRM-VARMLKRYG----PVVALPVLGYGTVVAVA
Mvan_0675|M.vanbaalenii_PYR-1 APVFGGLYAAAFGMGGQAI-VAQMVRRYG----PVVALPVLGFGKVVAVA
Mflv_1104|M.gilvum_PYR-GCK PRIPRFLQGLGFSLSRQWT-VAQVVRRYG----DVFTMTLPVFGKTVLVT
MSMEG_6478|M.smegmatis_MC2_155 LPLPKTVQGLAFSVARRWV-VKQAARRYG----DVVTLDIPVFGRTVLVT
MAV_5160|M.avium_104 VRGPKLLQGIGFAVSRRTM-MRRLSRRYG----NVFTLRLPMWGPVVMVS
MAB_4693|M.abscessus_ATCC_1997 PPLPLAVQSILMASYGLRF-LAGCQRRYG----NMFTLRIPLSGKVVYLA
MUL_0604|M.ulcerans_Agy99 PRNPLPYWQQLKALKTLHV-GSEALRDAGGSVTRIWLGPKRLVPPMVMVT
MLBr_02088|M.leprae_Br4923 EAQMLLLRLIDPGTRADPFPVYRALIDYG--PMQLPGMPLTVFSSFSDCD
* :
Mb3710c|M.bovis_AF2122/97 DSALAKEVFTAPTDVLLGGEG--VGPAAAIYGSGSMFVQEEPQHLRRRKL
Rv3685c|M.tuberculosis_H37Rv DSALAKEVFTAPTDVLLGGEG--VGPAAAIYGSGSMFVQEEPEHLRRRKL
MMAR_5175|M.marinum_M DPALVKEVFTAPPDVLLGGEG--VGPAAAIYGAGSMFVQEEPEHLRRRKL
TH_0136|M.thermoresistible__bu DPALARQVFAEKPDVLLGGDG--VGPAAAIYGPRSMFVQEEPEHLRRRRL
Mvan_0675|M.vanbaalenii_PYR-1 DAALAKQVFTENPDVLLGGEG--VGPAAAIYGPRSMFVLEEPGHLRRRRL
Mflv_1104|M.gilvum_PYR-GCK DPALAKQLFMANTD--DVGNI--QPNLSRVLGSGSVFALDGTDHRLRRKL
MSMEG_6478|M.smegmatis_MC2_155 EPQLAKQVYAAHPD--DVGNV--QPNLSRMLGPGSVFALDGTDHRRRRKL
MAV_5160|M.avium_104 DPQLAKQIFTTSPD--ELGNI--QPNLSRLFGSGSVFGLEGDDHRRRRRL
MAB_4693|M.abscessus_ATCC_1997 DPADIKTVYAGDPHVFHSGEA--HWFFRGLLGDSSLFVLDEDEHHHQRRL
MUL_0604|M.ulcerans_Agy99 SPQGARDVLGRSGALSDRGTLPLLKDLRRAIG-ESVLNLPHDTWLPRRRT
MLBr_02088|M.leprae_Br4923 EALRHPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKL
.. *.: *:
Mb3710c|M.bovis_AF2122/97 LTPPLHGAALDRYVPIIENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVK
Rv3685c|M.tuberculosis_H37Rv LTPPLHGAALDRYVPIIENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVK
MMAR_5175|M.marinum_M LTPPLHGTALGRYVPIIEESTRAAMRDWPVDRPFELLGAARALMLDVIVK
TH_0136|M.thermoresistible__bu LIPPLHGAALAGHVPVIEAATRSAMASWPVGRPMRMLDAARDLTLDVIIR
Mvan_0675|M.vanbaalenii_PYR-1 LTPPLHGELLGSYVPIIESSTRSAMATWPVGRPMRMLDAARELTLDVIVQ
Mflv_1104|M.gilvum_PYR-GCK LTPPFHGKSIKNYERIFEEETLREAASWPEGQPFETLEPMMRITLNAILR
MSMEG_6478|M.smegmatis_MC2_155 LTPPFHGRSIKNYERIFEEETLREAASWPDGQEFRTLEPMMRITLNVILR
MAV_5160|M.avium_104 LAPPFHGKSMKNYESIIEEETLRETAGWPEGESFPTLPPMMRITLNAILR
MAB_4693|M.abscessus_ATCC_1997 LMPAFHRDAVARQATQMAQIAAANIAEWPVGESFPVAPRTTDITLEVILR
MUL_0604|M.ulcerans_Agy99 LQPIFTKQRVAGFAGHMSEAANHILLGWPDGAEVDLNAASHALVLRVVGH
MLBr_02088|M.leprae_Br4923 VSKAFAPKVVQALEGDIAALVDSLLDKGAAAG-----------QFDVIAD
: : : : . . : .:
Mb3710c|M.bovis_AF2122/97 VIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGALRVWPARAR
Rv3685c|M.tuberculosis_H37Rv VIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGALRVWPARAR
MMAR_5175|M.marinum_M VIFGVDDPDEVRRLGRPFERLLDLGVSEQLTVRYALRRAGALRVWPQRAR
TH_0136|M.thermoresistible__bu VIFGVHDPAEVARLAAPFETLLALAVSVQTPVRYALRRAGALRFWHAYRD
Mvan_0675|M.vanbaalenii_PYR-1 VVFGVHDPESVARFGKPFHELLDLALSEETPVRYALRRFGALRRWGRLSD
Mflv_1104|M.gilvum_PYR-GCK AVFGADG-AHLDELRRIIPPWVTLGSRLAVLP-TPHRTYGRFSPWGRLAR
MSMEG_6478|M.smegmatis_MC2_155 AVFGADG-EQLDELRRIIPPWVTLGSRLAVLP-TPKRNYGRLTPWGRLAA
MAV_5160|M.avium_104 AVFGAEG-AELDELRRLIPPWVTLGSRLAALP-KPQR-YPRFGPWGQLDR
MAB_4693|M.abscessus_ATCC_1997 TVIGASDPVRLAALRKVVPRLLYMKP-WETPA-ITNPGLRRYWPWTAVGR
MUL_0604|M.ulcerans_Agy99 SVFGLDLQDKADVITTGVTLAAKWAADRSARP-VRAPHWLPTPARPRARG
MLBr_02088|M.leprae_Br4923 LAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATE
: :
Mb3710c|M.bovis_AF2122/97 ANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGESGEQLSDSEIRD
Rv3685c|M.tuberculosis_H37Rv ANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGESGEQLSDSEIRD
MMAR_5175|M.marinum_M AYREIEDVVMPLIAQRRSDLGRTEQRDILGLLISARGDDGEQLSDQEIRD
TH_0136|M.thermoresistible__bu ANRRIDELVRPLIAARR-VPDAGPRDDILSMLVAARTEDGDRLTDDEIRD
Mvan_0675|M.vanbaalenii_PYR-1 ANRRIDELVLPLIAERRSDPLSAERADILSMLANSHTDDGETLSDNEIRD
Mflv_1104|M.gilvum_PYR-GCK YRRRYDEVIGRLIDAVQADPNFESRDDVLALLLRSTYEDGSSMSRQDIGD
MSMEG_6478|M.smegmatis_MC2_155 YRAEYDDVVDRLIDRVEADPDFDQRDDILALLLRSAYEDGSSMSRKDIGD
MAV_5160|M.avium_104 WRRQYDGVIERLIAAEQADPNFAERTDVLALLLRSTYDDGAAMSHKEIGD
MAB_4693|M.abscessus_ATCC_1997 RMAETDALLYAEIAERRADPNLTERTDVLAMLVRATDDDGRTMSDQELRD
MUL_0604|M.ulcerans_Agy99 AYDAMYKIAADMLAACRADPSR-EAPLITALIDATGPNTGESLSDQQICD
MLBr_02088|M.leprae_Br4923 ERLRAGVWLRDYLEQLVKCRRGTPGEDLISRLIELD-ESGDQLTEEEIIA
: : . : : * :: .::
Mb3710c|M.bovis_AF2122/97 DLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGGGEA------
Rv3685c|M.tuberculosis_H37Rv DLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGGGEA------
MMAR_5175|M.marinum_M DLITLMLAGHETTATTLAWVFDLLLHHPDALRRVQEEAEGGTET------
TH_0136|M.thermoresistible__bu DLITLVLAGHETTATTLAWLIDYLVHHPAALDRVRAEAAPGGAQR-----
Mvan_0675|M.vanbaalenii_PYR-1 DLITLVLAGHETTATTLSWLIDLLLHHPRALARVRAEAVSGDTG------
Mflv_1104|M.gilvum_PYR-GCK ELLTLLAAGHETTAATLGWVFERISRHPDVLARLQAEADT----------
MSMEG_6478|M.smegmatis_MC2_155 ELLTLLAAGHETTASTLGWAFERISRHPGVLEKLVAEAAT----------
MAV_5160|M.avium_104 ELLTLLAAGHETTASTLAWAFERISRHPELLARLVEEADN----------
MAB_4693|M.abscessus_ATCC_1997 HLLTSIAAGHETTATALSWVLERLTRHPDALLKAAQAAEASAAGDP----
MUL_0604|M.ulcerans_Agy99 EMVYFMILGEDTTSTVLTYALWALGQHCQLQDRLAAEAAELGDRPLTPAD
MLBr_02088|M.leprae_Br4923 TCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQR----------
: *.:** : . : :: .
Mb3710c|M.bovis_AF2122/97 -----FTTAVINETLRVRPPAPLTAR-VAAQPLTIGGYRVEAGTRIVVHI
Rv3685c|M.tuberculosis_H37Rv -----FTTAVINETLRVRPPAPLTAR-VAAQPLTIGGYRVEAGTRIVVHI
MMAR_5175|M.marinum_M -----FTTAVINETLRVRPPAPFTAR-VAARPFRLGGYLIDPGTRIVVHM
TH_0136|M.thermoresistible__bu -GAGPYTEAVINETLRLRPPGPVTGR-TTAGHYRLGDYTLAPRTRIVLLL
Mvan_0675|M.vanbaalenii_PYR-1 -----YTEAVIAETLRLRPAAPITGR-MTTGPYRLGDYTLEPDTRIVLLL
Mflv_1104|M.gilvum_PYR-GCK -DGNEYRQAVILETQRVRTVIDFAGRHVYAPTFELGEWIIPQGYSIVVAI
MSMEG_6478|M.smegmatis_MC2_155 -DDNEYRQAAIAEVQRVRTVIDFSGRHVYAPSFQLGQWTIPRGYSIMVAI
MAV_5160|M.avium_104 -GGNELRQAAILEVQRARTVIDFAGRHVYPDVYRLGEWVIPRGYSIIVGI
MAB_4693|M.abscessus_ATCC_1997 -AGDEYLDAVVKETLRIRPVIFSSGR-VLKESVEVGGYQLPVGIMVDPAI
MUL_0604|M.ulcerans_Agy99 VPRLGYTIQVLQEAMRLRPPGPTVAR-RAMQDIEVDGYRVQAGTYCLVGV
MLBr_02088|M.leprae_Br4923 ------APLVVEETLRYDPAIHLIGR-VAAKDMTIGQTTLTEGDTMVLLL
.: *. * . .* :. : :
Mb3710c|M.bovis_AF2122/97 IAINRSAEVYEHPHEFRPERFLGT---RPQTYAWVPFGGGVKRCLGANFS
Rv3685c|M.tuberculosis_H37Rv IAINRSAEVYEHPHEFRPERFLGT---RPQTYAWVPFGGGVKRCLGANFS
MMAR_5175|M.marinum_M IAINRNPDVYEQPNRFRPERFLGT---RPQTYAWVPFGGGAKRCLGAAFS
TH_0136|M.thermoresistible__bu GVINRDPNSYPDPHDFRPDRFLHT---RPDPYAWVPFGGGVKRCLGAAFA
Mvan_0675|M.vanbaalenii_PYR-1 DVINRNPDTYPQPDEFRPERFLGS---RPHPYAWIPFGGGVKRCIGAAFA
Mflv_1104|M.gilvum_PYR-GCK GQVHHREQDYLDPEDFDPQRFVGQ---RPSTLSHIPFGGGTRRCVGAVFA
MSMEG_6478|M.smegmatis_MC2_155 AHIQEREEEFSDPHRFDPQRFVGN---RPG-LGWLPYGGGTRRCVGAVFA
MAV_5160|M.avium_104 AQIHDNPDVFPDPRRFDPQRFIDN---KPSALSWIPFGGGTRRCVGAAFA
MAB_4693|M.abscessus_ATCC_1997 GLVHASGAVYPDPARFDPDRMVGT---TLSPTTWLPFGGGNRRCLGATFA
MUL_0604|M.ulcerans_Agy99 YAMHRDPALWDDPLAFDPDRFAPKKSKGRDRWQYLPFGGGGRSCLGDHFA
MLBr_02088|M.leprae_Br4923 AAANRDPAVYSRPDEFDPDRPSSR---------HLAFAVGSHFCLGAALA
: : * * *:* :.:. * : *:* ::
Mb3710c|M.bovis_AF2122/97 MRELITVLHVLLREGEFTAVDDEPE-RIVRRSIMLVPRRGTRVRFRPAR-
Rv3685c|M.tuberculosis_H37Rv MRELITVLHVLLREGEFTAVDDEPE-RIVRRSIMLVPRRGTRVRFRPAR-
MMAR_5175|M.marinum_M MRELVTVLHVLLREGQFTAVDEAPE-RIVRRSIMLAPRHGTRVRFRPRLQ
TH_0136|M.thermoresistible__bu MRELTTILRILLTEADLRPVNARPESAAGRAAAVVVPRHGTPVYFRPTAP
Mvan_0675|M.vanbaalenii_PYR-1 MRELTTTLHTVLREGELEPVSARPETPPLRAAPVLVPRDGTRVRFTPARP
Mflv_1104|M.gilvum_PYR-GCK NVEMDIVLRTVFRHFTIETTTAPGE-KMHSRGVAYTPDDGGRVVMRRR--
MSMEG_6478|M.smegmatis_MC2_155 NIEMDVVLRTILRHFVIETTTAPDE-KVHPRGVAYTPASGGRVVMRRRRE
MAV_5160|M.avium_104 NMEMDVVLRTVLRHFTIETTDAPDE-PWHCRGVAFTPKHGGRIVVHRR--
MAB_4693|M.abscessus_ATCC_1997 MVEIRVVLREILRRVELNTTTAPDE-KQQAKHVTFVPHRGGSISVRAIRT
MUL_0604|M.ulcerans_Agy99 MLEASLALATIIREAEIHSLDGDFPVAIPLPIVPAGPIRARVNQRRPSQE
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAGELV---YKPNVAMRGMSALPVQV-----
* * : . .
Mb3710c|M.bovis_AF2122/97 ------------------------
Rv3685c|M.tuberculosis_H37Rv ------------------------
MMAR_5175|M.marinum_M ESV---------------------
TH_0136|M.thermoresistible__bu AASPRCAGRTSTV-----------
Mvan_0675|M.vanbaalenii_PYR-1 AASPRCADRTSTV-----------
Mflv_1104|M.gilvum_PYR-GCK ------------------------
MSMEG_6478|M.smegmatis_MC2_155 PLGA--------------------
MAV_5160|M.avium_104 ------------------------
MAB_4693|M.abscessus_ATCC_1997 CAPAVTPTCPADVHGTGQARDPQR
MUL_0604|M.ulcerans_Agy99 VCTTTLSDSSASS-----------
MLBr_02088|M.leprae_Br4923 ------------------------