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MSGTSSMGLPPGPRLSGSVQAVLMLRHGLRFLTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNP SVFHAGEANSMLAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEIAAANIAGWPMAKAFA VAPKMSEITLEVILRTVIGASDPVRLAALRKVMPRLLNVGPWATLALANPSLLNNRLWSRLRRRIEEADA LLYAEIADRRADPDLAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWALERLTRH PVTLAKAVQAADASAAGDPAGDEYLDAVAKETLRIRPVVYDVGRVLTEAVEVAGYRLPAGVMVVPAIGLV HASAQLYPDPERFDPDRMVGATLSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELSTTTTSGER PKLKHVIMVPHRGARIRVRATRDVSATSQATAQGAGCPAARGGGPSRAVGSQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0568 | cyp135B1 | - | 100% (472) | POSSIBLE CYTOCHROME P450 135B1 CYP135B1 |
| M. tuberculosis H37Rv | Rv0327c | cyp135A1 | 2e-86 | 40.68% (440) | cytochrome P450 135A1 |
| M. tuberculosis H37Rv | Rv0136 | cyp138 | 2e-77 | 38.24% (442) | cytochrome P450 138 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0583 | cyp135B1 | 0.0 | 100.00% (472) | cytochrome P450 135B1 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 9e-74 | 38.27% (439) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 8e-16 | 26.30% (327) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 1e-176 | 67.17% (460) | cytochrome P450 |
| M. marinum M | MMAR_0938 | cyp135B4 | 0.0 | 75.32% (462) | cytochrome P450 135B4 Cyp135B4 |
| M. avium 104 | MAV_5160 | - | 4e-75 | 37.84% (444) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1213 | - | 1e-171 | 67.57% (441) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_2672 | - | 1e-177 | 71.79% (429) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 2e-30 | 28.33% (406) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_1038 | - | 1e-177 | 73.97% (438) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1104|M.gilvum_PYR-GCK -------------------MRLPPTPRIPR----FLQGLGFSLSRQWT--
MAV_5160|M.avium_104 --------MSEVATAPLAAVHLPPAVRGPK----LLQGIGFAVSRRTM--
Rv0568|M.tuberculosis_H37Rv -------------MSGTSSMGLPPGPRLSG----SVQAVLMLRHGLRF--
Mb0583|M.bovis_AF2122/97 -------------MSGTSSMGLPPGPRLSG----SVQAVLMLRHGLRF--
MMAR_0938|M.marinum_M ---------------MTKTATLPPGPRLPR----AVQAALMLRHAPRF--
MSMEG_1213|M.smegmatis_MC2_155 -----------------------------------MQTAMMLRHWSRF--
Mvan_1038|M.vanbaalenii_PYR-1 MRDPRYGRGRAFYAGVMTPTSLPPGPRLPR----SVQAALMLRCGPRF--
TH_2672|M.thermoresistible__bu -----------------------------------VQAWLMLRHGKWF--
MAB_4693|M.abscessus_ATCC_1997 -------------MSKTAKIALPPGPPLPL----AVQSILMASYGLRF--
MUL_0604|M.ulcerans_Agy99 ------------MVDPPDIRSLPLAPRNPLPYWQQLKALKTLHVGSEA--
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:
Mflv_1104|M.gilvum_PYR-GCK --VAQVVRRYGDVFTMTLPVFGKTVLVTDPALAKQLFMANTD--DVGNIQ
MAV_5160|M.avium_104 --MRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIFTTSPD--ELGNIQ
Rv0568|M.tuberculosis_H37Rv --LTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEAN
Mb0583|M.bovis_AF2122/97 --LTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEAN
MMAR_0938|M.marinum_M --LTACKRRYGSVFTLRVAGLGTMVNVTDPVVIKKVFAGDPRVFHAGEAN
MSMEG_1213|M.smegmatis_MC2_155 --VSACRRRYGDVFTLRIASMGTWVYLADPADIKTVFAGDPTVFHAGEAN
Mvan_1038|M.vanbaalenii_PYR-1 --VAACRRRYGSAFTLRVASMGTLVYLTDPADIKTVFAGDPDIYHAGEAN
TH_2672|M.thermoresistible__bu --IAACQRRYGPVFTLRITSMGTLVYLTDPADIKAVFTGDPDTFHAGEAN
MAB_4693|M.abscessus_ATCC_1997 --LAGCQRRYGNMFTLRIPLSGKVVYLADPADIKTVYAGDPHVFHSGEAH
MUL_0604|M.ulcerans_Agy99 --LRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVLGRSGALSDRGTLP
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
: : .
Mflv_1104|M.gilvum_PYR-GCK PN----LSRVLGSGSVFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEE
MAV_5160|M.avium_104 PN----LSRLFGSGSVFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEE
Rv0568|M.tuberculosis_H37Rv SM----LAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEI
Mb0583|M.bovis_AF2122/97 SM----LAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEI
MMAR_0938|M.marinum_M TM----LAGLLGESSLLVVDDDVHRDRRRMMLPPFQREAVAHQAQLMSEI
MSMEG_1213|M.smegmatis_MC2_155 SM----LSGLLGETSVLVIDEDVHRDRRRLMLAPFARDAVARQTGVMAEV
Mvan_1038|M.vanbaalenii_PYR-1 SM----LKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEI
TH_2672|M.thermoresistible__bu SM----LSGILGETSVLVIDGDLHRRRRRLMLPSFHRDAVTRQADAMAEI
MAB_4693|M.abscessus_ATCC_1997 WF----FRGLLGDSSLFVLDEDEHHHQRRLLMPAFHRDAVARQATQMAQI
MUL_0604|M.ulcerans_Agy99 LLKD--LRRAIG-ESVLNLPHDTWLPRRRTLQPIFTKQRVAGFAGHMSEA
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
: *.: : *: : * . : :
Mflv_1104|M.gilvum_PYR-GCK TLREAASWPEGQPFETLEPMMRITLNAILRAVFGADG-AHLDELRRIIPP
MAV_5160|M.avium_104 TLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEG-AELDELRRLIPP
Rv0568|M.tuberculosis_H37Rv AAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPR
Mb0583|M.bovis_AF2122/97 AAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPR
MMAR_0938|M.marinum_M AAENIAGWPVGRTFAVAPKMAEITLEVILRTVIGATDPDRLAALRKVMPR
MSMEG_1213|M.smegmatis_MC2_155 AATNIASWPVGTPFPVAPKMAEIALEVILRTVIGATEPARLAALRHVMPQ
Mvan_1038|M.vanbaalenii_PYR-1 AADNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPR
TH_2672|M.thermoresistible__bu AAADIAGWPVGTTFAAAPRMSQITLEVILRVVIGAGDPGRLAALRTVLPR
MAB_4693|M.abscessus_ATCC_1997 AAANIAEWPVGESFPVAPRTTDITLEVILRTVIGASDPVRLAALRKVVPR
MUL_0604|M.ulcerans_Agy99 ANHILLGWPDGAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVTL
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALL
. . . . .: ::*
Mflv_1104|M.gilvum_PYR-GCK WVTLGSRLAVLPTPHRTYGRFSPWGRLARYRRRYDEVIGRLIDAVQADPN
MAV_5160|M.avium_104 WVTLGSRLAALPKPQR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADPN
Rv0568|M.tuberculosis_H37Rv LLNVGP-WATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPD
Mb0583|M.bovis_AF2122/97 LLNVGP-WATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPD
MMAR_0938|M.marinum_M LLNVGP-WETLALAKPDLLSRRAWRRLRRAIDEANELLYAEIAERRADPN
MSMEG_1213|M.smegmatis_MC2_155 LLGIGP-WQSLAIASPGLQRRRPWRTLQRNLAEADRLLYAEIAACRAGPD
Mvan_1038|M.vanbaalenii_PYR-1 VLSVGP-WETLAIANQDLLRRRPWRAVRDAIAEADRLLYAEIADRRADPD
TH_2672|M.thermoresistible__bu LIDIGP-WLSLAVASPHLQRHRPWQRLQRNLADADRLLYAEIAERRADPE
MAB_4693|M.abscessus_ATCC_1997 LLYMKP-WETPAITNPGLRRYWPWTAVGRRMAETDALLYAEIAERRADPN
MUL_0604|M.ulcerans_Agy99 AAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADMLAACRADPS
MLBr_02088|M.leprae_Br4923 VQSVDP---FITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE--
. . .
Mflv_1104|M.gilvum_PYR-GCK FESRDDVLALLLRSTYEDGS----SMSRQDIGDELLTLLAAGHETTAATL
MAV_5160|M.avium_104 FAERTDVLALLLRSTYDDGA----AMSHKEIGDELLTLLAAGHETTASTL
Rv0568|M.tuberculosis_H37Rv LAARTDTLAMLVRAADEDGR----TMTERELRDQLITLLVAGHDTTATGL
Mb0583|M.bovis_AF2122/97 LAARTDTLAMLVRAADEDGR----TMTERELRDQLITLLVAGHDTTATGL
MMAR_0938|M.marinum_M LAERTDVLATLVRAVDGDTAKPSGRMTDEELRDQLMTLLVAGHDTTATGL
MSMEG_1213|M.smegmatis_MC2_155 LASRPDALAMLVRAANDEGR----TMTDRELRDQLMTLLVAGHETTATGL
Mvan_1038|M.vanbaalenii_PYR-1 LDTRTDALAMLVRAG---------DMSDKELRDQLITLLVAGHDTTATAL
TH_2672|M.thermoresistible__bu LDTRTDTLAMLVRSADDDGQ----AMSDRELRDQLMTLLLAGHDTTATAL
MAB_4693|M.abscessus_ATCC_1997 LTERTDVLAMLVRATDDDGR----TMSDQELRDHLLTSIAAGHETTATAL
MUL_0604|M.ulcerans_Agy99 RE--APLITALIDATGPNTG---ESLSDQQICDEMVYFMILGEDTTSTVL
MLBr_02088|M.leprae_Br4923 -----DLISRLIELDESGDQ-----LTEEEIIATCGLLLVAGHETTVNLI
:: *: :: .:: : *.:** :
Mflv_1104|M.gilvum_PYR-GCK GWVFERISRHPDVLARLQAEAD-----------TDGNEYRQAVILETQRV
MAV_5160|M.avium_104 AWAFERISRHPELLARLVEEAD-----------NGGNELRQAAILEVQRA
Rv0568|M.tuberculosis_H37Rv SWALERLTRHPVTLAKAVQAADAS-----AAGDPAGDEYLDAVAKETLRI
Mb0583|M.bovis_AF2122/97 SWALERLTRHPVTLAKAVQAADAS-----AAGDPAGDEYLDAVAKETLRI
MMAR_0938|M.marinum_M AWALERLTRHPAILAKAVRAAEAS-----AAGDPSGDEYLDALAKETLRI
MSMEG_1213|M.smegmatis_MC2_155 SWTLERLIRHPAVLDKAVAAAR--------TTDGSGEAYLDAVVRESLRI
Mvan_1038|M.vanbaalenii_PYR-1 SWALERLTRHPAVLAKAVRAAR--------DGD---DDYLDAVAKETLRD
TH_2672|M.thermoresistible__bu SWALERLTRHPMLLAEAEQAAEAS-----AAGDPAGDEYLDAVCRETLRN
MAB_4693|M.abscessus_ATCC_1997 SWVLERLTRHPDALLKAAQAAEAS-----AAGDPAGDEYLDAVVKETLRI
MUL_0604|M.ulcerans_Agy99 TYALWALGQHCQLQDRLAAEAAELGDRPLTPADVPRLGYTIQVLQEAMRL
MLBr_02088|M.leprae_Br4923 ANAVLAMLRNPSQWKALSSNPQ----------------RAPLVVEETLRY
.. : :: . * *
Mflv_1104|M.gilvum_PYR-GCK RTVIDFAGRHVYAPTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPEDFD
MAV_5160|M.avium_104 RTVIDFAGRHVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFD
Rv0568|M.tuberculosis_H37Rv RPVVYDVGR-VLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFD
Mb0583|M.bovis_AF2122/97 RPVVYDVGR-VLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFD
MMAR_0938|M.marinum_M RPVVFDVGR-ILTEPTELAGYQLPAGTMVVASIGLVHANAEVYPDPDRFD
MSMEG_1213|M.smegmatis_MC2_155 RPVVFEAGR-VLTEPVELGGYLLPAGTLVAPSIGLVHASADVYPDPDRFE
Mvan_1038|M.vanbaalenii_PYR-1 RPVVFDVGR-VLKAPVELAGYRLPAGVMVIPGLVAVHADSQIYPHADRFD
TH_2672|M.thermoresistible__bu RTVVFDVGR-VLKRPVELAGHRLPAGVMVVPGMVRVHADGELYPDPERFD
MAB_4693|M.abscessus_ATCC_1997 RPVIFSSGR-VLKESVEVGGYQLPVGIMVDPAIGLVHASGAVYPDPARFD
MUL_0604|M.ulcerans_Agy99 RPPGPTVAR-RAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFD
MLBr_02088|M.leprae_Br4923 DPAIHLIGR-VAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFD
. .* : : * : : : . *:
Mflv_1104|M.gilvum_PYR-GCK PQRFVGQR-----PSTLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFRHF
MAV_5160|M.avium_104 PQRFIDNK-----PSALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHF
Rv0568|M.tuberculosis_H37Rv PDRMVGAT-----LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRV
Mb0583|M.bovis_AF2122/97 PDRMVGAT-----LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRV
MMAR_0938|M.marinum_M PDRMIDAT-----LTPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRV
MSMEG_1213|M.smegmatis_MC2_155 PDRMLAST-----QAPSTWLPFGGGNRRCLGATFALVEMRVVLREILHRV
Mvan_1038|M.vanbaalenii_PYR-1 PDRMLGAT-----LSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRV
TH_2672|M.thermoresistible__bu PHRMLGETPGQPALTPTTWFPFGGGNRRCLGATFAMVEMRVVLREILRRV
MAB_4693|M.abscessus_ATCC_1997 PDRMVGTT-----LSPTTWLPFGGGNRRCLGATFAMVEIRVVLREILRRV
MUL_0604|M.ulcerans_Agy99 PDRFAPKKS--KGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATIIREA
MLBr_02088|M.leprae_Br4923 PDRPSSRH-----------LAFAVGSHFCLGAALARLEATVTLSAIS--A
*.* :.*. * : *:* :* :* :.* :
Mflv_1104|M.gilvum_PYR-GCK TIETTTAPGEKMHSRGVAYTPDDGGRVVMRRR------------------
MAV_5160|M.avium_104 TIETTDAPDEPWHCRGVAFTPKHGGRIVVHRR------------------
Rv0568|M.tuberculosis_H37Rv ELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATS--QATAQGAGC
Mb0583|M.bovis_AF2122/97 ELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATS--QATAQGAGC
MMAR_0938|M.marinum_M DLATTTAPDERYKLKHVILVPHRDARIRVRA---ITAVS--PAVPEAPGC
MSMEG_1213|M.smegmatis_MC2_155 DLFATTARGEKQRLKHVTMIPHRGGRICVRALR--------DVAPAPMTC
Mvan_1038|M.vanbaalenii_PYR-1 ELETTTARGEHRRLKHVIFVPHRGARIRVRAKR--------VVAAEAPKC
TH_2672|M.thermoresistible__bu ELETTSARGERPRLKHVVFVPRRGARIRVRAHRKPVADNTVDDAAGPVPS
MAB_4693|M.abscessus_ATCC_1997 ELNTTTAPDEKQQAKHVTFVPHRGGSISVRAIR-------TCAPAVTPTC
MUL_0604|M.ulcerans_Agy99 EIHSLDG--DFPVAIPLPIVPAGPIRARVNQRR--------PSQEVCTTT
MLBr_02088|M.leprae_Br4923 RFPQVQLAGELVYKPNVAMRGMSALPVQV---------------------
: : : :
Mflv_1104|M.gilvum_PYR-GCK ---------------
MAV_5160|M.avium_104 ---------------
Rv0568|M.tuberculosis_H37Rv PAARGGGPSRAVGSQ
Mb0583|M.bovis_AF2122/97 PAARGGGPSRAVGSQ
MMAR_0938|M.marinum_M PVAHAKS--------
MSMEG_1213|M.smegmatis_MC2_155 PAEARRA--------
Mvan_1038|M.vanbaalenii_PYR-1 PMSGPA---------
TH_2672|M.thermoresistible__bu PVPPRR---------
MAB_4693|M.abscessus_ATCC_1997 PADVHGTGQARDPQR
MUL_0604|M.ulcerans_Agy99 LSDSSASS-------
MLBr_02088|M.leprae_Br4923 ---------------