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VRPPSLPAPPPLAPVFGGLYAAAFGMGGQAIVAQMVRRYGPVVALPVLGFGKVVAVADAALAKQVFTENP DVLLGGEGVGPAAAIYGPRSMFVLEEPGHLRRRRLLTPPLHGELLGSYVPIIESSTRSAMATWPVGRPMR MLDAARELTLDVIVQVVFGVHDPESVARFGKPFHELLDLALSEETPVRYALRRFGALRRWGRLSDANRRI DELVLPLIAERRSDPLSAERADILSMLANSHTDDGETLSDNEIRDDLITLVLAGHETTATTLSWLIDLLL HHPRALARVRAEAVSGDTGYTEAVIAETLRLRPAAPITGRMTTGPYRLGDYTLEPDTRIVLLLDVINRNP DTYPQPDEFRPERFLGSRPHPYAWIPFGGGVKRCIGAAFAMRELTTTLHTVLREGELEPVSARPETPPLR AAPVLVPRDGTRVRFTPARPAASPRCADRTSTV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0675 | - | - | 100% (453) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5712 | - | 3e-72 | 37.24% (435) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3108 | - | 4e-66 | 34.25% (438) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3710c | cyp137 | 1e-152 | 61.33% (437) | cytochrome P450 137 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 6e-72 | 37.62% (428) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3685c | cyp137 | 1e-152 | 61.33% (437) | cytochrome P450 137 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-17 | 28.04% (321) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 1e-67 | 35.10% (453) | cytochrome P450 |
| M. marinum M | MMAR_5175 | cyp137A2 | 1e-154 | 61.70% (436) | cytochrome P450 137A2 Cyp137A2 |
| M. avium 104 | MAV_5160 | - | 8e-73 | 37.56% (434) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6478 | - | 3e-70 | 36.30% (427) | putative cytochrome P450 135B1 |
| M. thermoresistible (build 8) | TH_0136 | - | 0.0 | 71.40% (458) | PROBABLE CYTOCHROME P450 137 CYP137 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 2e-27 | 27.35% (468) | cytochrome P450 136A2 Cyp136A2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0675|M.vanbaalenii_PYR-1 ---------------------------------------------MRPPS
TH_0136|M.thermoresistible__bu ---------------------------------------------VRPPS
Mb3710c|M.bovis_AF2122/97 -------MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPG
Rv3685c|M.tuberculosis_H37Rv -------MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPG
MMAR_5175|M.marinum_M ----------MPASAPSARTPP---------------------ALRRPPG
Mflv_1104|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6478|M.smegmatis_MC2_155 -------------------------------------MTATVERPESAIR
MAV_5160|M.avium_104 ----------------------------------------MSEVATAPLA
MAB_4693|M.abscessus_ATCC_1997 ---------------------------------------------MSKTA
MUL_3402|M.ulcerans_Agy99 MATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPPP
MLBr_02088|M.leprae_Br4923 ---------------------------MRTCVPTRTCVYAFIEYLSHNRP
Mvan_0675|M.vanbaalenii_PYR-1 LPAPPPLA---PVFGGLYAAAFGMGGQAIVAQMVRRYGPVVALPVLGFGK
TH_0136|M.thermoresistible__bu LPAPAPLS---AVFGAGYAAAYAVGGNRMVARMLKRYGPVVALPVLGYGT
Mb3710c|M.bovis_AF2122/97 LPAPRGFR---AAFAAAYAVAYLAGGERRMLRLIRRYGPIMTMPILSLGD
Rv3685c|M.tuberculosis_H37Rv LPAPRGFR---AAFAAAYAVAYLAGGERRMLRLIRRYGPIMTMPILSLGD
MMAR_5175|M.marinum_M LPAPRRLR---TVFAAAYAVAYLVGGERRMLRLIRRYGPIMTMPILSLGD
Mflv_1104|M.gilvum_PYR-GCK -MRLPPTP---RIPRFLQGLGFSLSRQWTVAQVVRRYGDVFTMTLPVFGK
MSMEG_6478|M.smegmatis_MC2_155 AAQLPPVL---PLPKTVQGLAFSVARRWVVKQAARRYGDVVTLDIPVFGR
MAV_5160|M.avium_104 AVHLPPAV---RGPKLLQGIGFAVSRRTMMRRLSRRYGNVFTLRLPMWGP
MAB_4693|M.abscessus_ATCC_1997 KIALPPGP---PLPLAVQSILMASYGLRFLAGCQRRYGNMFTLRIPLSGK
MUL_3402|M.ulcerans_Agy99 GSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLSA
MLBr_02088|M.leprae_Br4923 MGTNPPSLVEAQMLLLRLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVF
: * :
Mvan_0675|M.vanbaalenii_PYR-1 VVAVADAALAKQVFTE----NPDVLLGGEGVGPAAAIYGPRSMFVLEEPG
TH_0136|M.thermoresistible__bu VVAVADPALARQVFAE----KPDVLLGGDGVGPAAAIYGPRSMFVQEEPE
Mb3710c|M.bovis_AF2122/97 VAIVSDSALAKEVFTA----PTDVLLGGEGVGPAAAIYGSGSMFVQEEPQ
Rv3685c|M.tuberculosis_H37Rv VAIVSDSALAKEVFTA----PTDVLLGGEGVGPAAAIYGSGSMFVQEEPE
MMAR_5175|M.marinum_M VAIVSDPALVKEVFTA----PPDVLLGGEGVGPAAAIYGAGSMFVQEEPE
Mflv_1104|M.gilvum_PYR-GCK TVLVTDPALAKQLFMA----NTD--DVGNIQPNLSRVLGSGSVFALDGTD
MSMEG_6478|M.smegmatis_MC2_155 TVLVTEPQLAKQVYAA----HPD--DVGNVQPNLSRMLGPGSVFALDGTD
MAV_5160|M.avium_104 VVMVSDPQLAKQIFTT----SPD--ELGNIQPNLSRLFGSGSVFGLEGDD
MAB_4693|M.abscessus_ATCC_1997 VVYLADPADIKTVYAG----DPHVFHSGEAHWFFRGLLGDSSLFVLDEDE
MUL_3402|M.ulcerans_Agy99 VVALG-PDAAQVIYSN----RNKDYSQQGWVPVIGPFFRRG-LMLLDFEE
MLBr_02088|M.leprae_Br4923 SSFSDCDEALRHPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPD
: .: :
Mvan_0675|M.vanbaalenii_PYR-1 HLRRRRLLTPPLHGELLGSYVPIIESSTRSAMA-TWPVGRP-MRMLDAAR
TH_0136|M.thermoresistible__bu HLRRRRLLIPPLHGAALAGHVPVIEAATRSAMA-SWPVGRP-MRMLDAAR
Mb3710c|M.bovis_AF2122/97 HLRRRKLLTPPLHGAALDRYVPIIENSTRAAMH-TWPVDRP-FAMLTVAR
Rv3685c|M.tuberculosis_H37Rv HLRRRKLLTPPLHGAALDRYVPIIENSTRAAMH-TWPVDRP-FAMLTVAR
MMAR_5175|M.marinum_M HLRRRKLLTPPLHGTALGRYVPIIEESTRAAMR-DWPVDRP-FELLGAAR
Mflv_1104|M.gilvum_PYR-GCK HRLRRKLLTPPFHGKSIKNYERIFEEETLREAA-SWPEGQP-FETLEPMM
MSMEG_6478|M.smegmatis_MC2_155 HRRRRKLLTPPFHGRSIKNYERIFEEETLREAA-SWPDGQE-FRTLEPMM
MAV_5160|M.avium_104 HRRRRRLLAPPFHGKSMKNYESIIEEETLRETA-GWPEGES-FPTLPPMM
MAB_4693|M.abscessus_ATCC_1997 HHHQRRLLMPAFHRDAVARQATQMAQIAAANIA-EWPVGES-FPVAPRTT
MUL_3402|M.ulcerans_Agy99 HMFHRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMK
MLBr_02088|M.leprae_Br4923 HTRLRKLVSKAFAPKVVQALEGDIAALVDSLLD-------------KGAA
* *::: .: : : .
Mvan_0675|M.vanbaalenii_PYR-1 ELTLDVIVQVVFGVHDPESVARFGKPFHELLDLALSEETPVRYALRRFGA
TH_0136|M.thermoresistible__bu DLTLDVIIRVIFGVHDPAEVARLAAPFETLLALAVSVQTPVRYALRRAGA
Mb3710c|M.bovis_AF2122/97 SLMLDVIVKVIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGA
Rv3685c|M.tuberculosis_H37Rv SLMLDVIVKVIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGA
MMAR_5175|M.marinum_M ALMLDVIVKVIFGVDDPDEVRRLGRPFERLLDLGVSEQLTVRYALRRAGA
Mflv_1104|M.gilvum_PYR-GCK RITLNAILRAVFGADG-AHLDELRRIIPPWVTLGSRLAVLP-TPHRTYGR
MSMEG_6478|M.smegmatis_MC2_155 RITLNVILRAVFGADG-EQLDELRRIIPPWVTLGSRLAVLP-TPKRNYGR
MAV_5160|M.avium_104 RITLNAILRAVFGAEG-AELDELRRLIPPWVTLGSRLAALP-KPQR-YPR
MAB_4693|M.abscessus_ATCC_1997 DITLEVILRTVIGASDPVRLAALRKVVPRLLYMKP-WETPA-ITNPGLRR
MUL_3402|M.ulcerans_Agy99 KLTLDIASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTW
MLBr_02088|M.leprae_Br4923 AGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITI
:: : .
Mvan_0675|M.vanbaalenii_PYR-1 LRRWGRLSDANRRIDELVLPLIAERRSDPLSAERADILSMLANSHTDDGE
TH_0136|M.thermoresistible__bu LRFWHAYRDANRRIDELVRPLIAARR-VPDAGPRDDILSMLVAARTEDGD
Mb3710c|M.bovis_AF2122/97 LRVWPARARANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGESGE
Rv3685c|M.tuberculosis_H37Rv LRVWPARARANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGESGE
MMAR_5175|M.marinum_M LRVWPQRARAYREIEDVVMPLIAQRRSDLGRTEQRDILGLLISARGDDGE
Mflv_1104|M.gilvum_PYR-GCK FSPWGRLARYRRRYDEVIGRLIDAVQADPNFESRDDVLALLLRSTYEDGS
MSMEG_6478|M.smegmatis_MC2_155 LTPWGRLAAYRAEYDDVVDRLIDRVEADPDFDQRDDILALLLRSAYEDGS
MAV_5160|M.avium_104 FGPWGQLDRWRRQYDGVIERLIAAEQADPNFAERTDVLALLLRSTYDDGA
MAB_4693|M.abscessus_ATCC_1997 YWPWTAVGRRMAETDALLYAEIAERRADPNLTERTDVLAMLVRATDDDGR
MUL_3402|M.ulcerans_Agy99 WR--------GIRARQLLENYFAARVTERRGQEGNDLLTVLCHTADEDGN
MLBr_02088|M.leprae_Br4923 TGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGEDLISRLIELD-ESGD
. : : *:: * :.*
Mvan_0675|M.vanbaalenii_PYR-1 TLSDNEIRDDLITLVLAGHETTATTLSWLIDLLLHHPRALARVRAEAVSG
TH_0136|M.thermoresistible__bu RLTDDEIRDDLITLVLAGHETTATTLAWLIDYLVHHPAALDRVRAEAAPG
Mb3710c|M.bovis_AF2122/97 QLSDSEIRDDLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGG
Rv3685c|M.tuberculosis_H37Rv QLSDSEIRDDLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGG
MMAR_5175|M.marinum_M QLSDQEIRDDLITLMLAGHETTATTLAWVFDLLLHHPDALRRVQEEAEGG
Mflv_1104|M.gilvum_PYR-GCK SMSRQDIGDELLTLLAAGHETTAATLGWVFERISRHPDVLARLQAEADT-
MSMEG_6478|M.smegmatis_MC2_155 SMSRKDIGDELLTLLAAGHETTASTLGWAFERISRHPGVLEKLVAEAAT-
MAV_5160|M.avium_104 AMSHKEIGDELLTLLAAGHETTASTLAWAFERISRHPELLARLVEEADN-
MAB_4693|M.abscessus_ATCC_1997 TMSDQELRDHLLTSIAAGHETTATALSWVLERLTRHPDALLKAAQAAEAS
MUL_3402|M.ulcerans_Agy99 RFSDQDIVNHMIFLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRL
MLBr_02088|M.leprae_Br4923 QLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQR-
:: .:: : *.*:*:. : :* .
Mvan_0675|M.vanbaalenii_PYR-1 DTG-----------YTEAVIAETLRLRPAAPITGR-MTTGPYRLGDYTLE
TH_0136|M.thermoresistible__bu GAQR------GAGPYTEAVINETLRLRPPGPVTGR-TTAGHYRLGDYTLA
Mb3710c|M.bovis_AF2122/97 GEA-----------FTTAVINETLRVRPPAPLTAR-VAAQPLTIGGYRVE
Rv3685c|M.tuberculosis_H37Rv GEA-----------FTTAVINETLRVRPPAPLTAR-VAAQPLTIGGYRVE
MMAR_5175|M.marinum_M TET-----------FTTAVINETLRVRPPAPFTAR-VAARPFRLGGYLID
Mflv_1104|M.gilvum_PYR-GCK ----------DGNEYRQAVILETQRVRTVIDFAGRHVYAPTFELGEWIIP
MSMEG_6478|M.smegmatis_MC2_155 ----------DDNEYRQAAIAEVQRVRTVIDFSGRHVYAPSFQLGQWTIP
MAV_5160|M.avium_104 ----------GGNELRQAAILEVQRARTVIDFAGRHVYPDVYRLGEWVIP
MAB_4693|M.abscessus_ATCC_1997 AAGDP-----AGDEYLDAVVKETLRIRPVIFSSGR-VLKESVEVGGYQLP
MUL_3402|M.ulcerans_Agy99 GDGPLDIEALEKLESLDLVMNESIRLVTPVQWAMRQTVRDTELLG-YYLP
MLBr_02088|M.leprae_Br4923 ---------------APLVVEETLRYDPAIHLIGR-VAAKDMTIGQTTLT
.: * * . * :* :
Mvan_0675|M.vanbaalenii_PYR-1 PDTRIVLLLDVINRNPDTYPQPDEFRPERFLG----SRPHPYAWIPFGGG
TH_0136|M.thermoresistible__bu PRTRIVLLLGVINRDPNSYPDPHDFRPDRFLH----TRPDPYAWVPFGGG
Mb3710c|M.bovis_AF2122/97 AGTRIVVHIIAINRSAEVYEHPHEFRPERFLG----TRPQTYAWVPFGGG
Rv3685c|M.tuberculosis_H37Rv AGTRIVVHIIAINRSAEVYEHPHEFRPERFLG----TRPQTYAWVPFGGG
MMAR_5175|M.marinum_M PGTRIVVHMIAINRNPDVYEQPNRFRPERFLG----TRPQTYAWVPFGGG
Mflv_1104|M.gilvum_PYR-GCK QGYSIVVAIGQVHHREQDYLDPEDFDPQRFVG----QRPSTLSHIPFGGG
MSMEG_6478|M.smegmatis_MC2_155 RGYSIMVAIAHIQEREEEFSDPHRFDPQRFVG----NRPG-LGWLPYGGG
MAV_5160|M.avium_104 RGYSIIVGIAQIHDNPDVFPDPRRFDPQRFID----NKPSALSWIPFGGG
MAB_4693|M.abscessus_ATCC_1997 VGIMVDPAIGLVHASGAVYPDPARFDPDRMVG----TTLSPTTWLPFGGG
MUL_3402|M.ulcerans_Agy99 KGTNVIAYPGMNHRLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGG
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS----------RHLAFAVG
: : : * * *:* .:. *
Mvan_0675|M.vanbaalenii_PYR-1 VKRCIGAAFAMRELTTTLHTVLREGELEPVSARPETPPLRAAPVLVPRDG
TH_0136|M.thermoresistible__bu VKRCLGAAFAMRELTTILRILLTEADLRPVNARPESAAGRAAAVVVPRHG
Mb3710c|M.bovis_AF2122/97 VKRCLGANFSMRELITVLHVLLREGEFTAVDDEPE-RIVRRSIMLVPRRG
Rv3685c|M.tuberculosis_H37Rv VKRCLGANFSMRELITVLHVLLREGEFTAVDDEPE-RIVRRSIMLVPRRG
MMAR_5175|M.marinum_M AKRCLGAAFSMRELVTVLHVLLREGQFTAVDEAPE-RIVRRSIMLAPRHG
Mflv_1104|M.gilvum_PYR-GCK TRRCVGAVFANVEMDIVLRTVFRHFTIETTTAPGE-KMHSRGVAYTPDDG
MSMEG_6478|M.smegmatis_MC2_155 TRRCVGAVFANIEMDVVLRTILRHFVIETTTAPDE-KVHPRGVAYTPASG
MAV_5160|M.avium_104 TRRCVGAAFANMEMDVVLRTVLRHFTIETTDAPDE-PWHCRGVAFTPKHG
MAB_4693|M.abscessus_ATCC_1997 NRRCLGATFAMVEIRVVLREILRRVELNTTTAPDE-KQQAKHVTFVPHRG
MUL_3402|M.ulcerans_Agy99 AHKCLGMVFGQLEIKTILHRLLRRYRLELARPDYR-ACWDYGGMPVPKDG
MLBr_02088|M.leprae_Br4923 SHFCLGAALARLEATVTLSAISARFPQVQLAGELV---YKPNVAMRGMSA
: *:* :. * * : . .
Mvan_0675|M.vanbaalenii_PYR-1 TRVRFTPARPAASPRCADRTSTV-----------
TH_0136|M.thermoresistible__bu TPVYFRPTAPAASPRCAGRTSTV-----------
Mb3710c|M.bovis_AF2122/97 TRVRFRPAR-------------------------
Rv3685c|M.tuberculosis_H37Rv TRVRFRPAR-------------------------
MMAR_5175|M.marinum_M TRVRFRPRLQESV---------------------
Mflv_1104|M.gilvum_PYR-GCK GRVVMRRR--------------------------
MSMEG_6478|M.smegmatis_MC2_155 GRVVMRRRREPLGA--------------------
MAV_5160|M.avium_104 GRIVVHRR--------------------------
MAB_4693|M.abscessus_ATCC_1997 GSISVRAIRTCAPAVTPTCPADVHGTGQARDPQR
MUL_3402|M.ulcerans_Agy99 MPIVLRPL--------------------------
MLBr_02088|M.leprae_Br4923 LPVQV-----------------------------
: .