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TSTLPALDVDLADGNFYADGRAAREAYKWMRANQPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRP DQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDKVPSIENLCDTLIDAVCERGECDFVRDIAAPLPMAV IGDMLGVLPDERDMLLKWSDDLVCGLSSTVDEQTIQKLMDTFAAYTAFTTEVIADRRANPRDDLFSVLVN AEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHQDQWRQAVADPELLPGAIEEMLRWTSPV KNMCRTLTADTEFHGTSLKAGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLAR LELRLMLTKILQRLPDLRLADESMLPLRPANFVSGLESMPVVFTPTAPVGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5217 | - | - | 100% (402) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0246 | - | 1e-66 | 38.37% (404) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | 1e-63 | 38.73% (377) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3547c | cyp142b | 9e-88 | 79.27% (193) | cytochrome P450 monooxygenase |
| M. gilvum PYR-GCK | Mflv_1541 | - | 0.0 | 92.52% (401) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 1e-180 | 78.28% (396) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-42 | 32.49% (317) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 3e-59 | 33.58% (408) | cytochrome P450 |
| M. marinum M | MMAR_5003 | cyp142A3 | 1e-178 | 76.81% (401) | cytochrome P450 142A3 Cyp142A3 |
| M. avium 104 | MAV_0641 | - | 0.0 | 83.17% (404) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_5918 | - | 0.0 | 86.00% (400) | P450 heme-thiolate protein |
| M. thermoresistible (build 8) | TH_3500 | - | 0.0 | 78.11% (402) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_4077 | cyp142A3 | 1e-177 | 76.31% (401) | cytochrome P450 142A3 Cyp142A3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3547c|M.bovis_AF2122/97 --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv --------------------------MTE---APDVDLADGNFYASR-EA
MMAR_5003|M.marinum_M --------------------------MTKPLIKPDVDLTDGNFYASR-QA
MUL_4077|M.ulcerans_Agy99 ------------------------MAMTKPLIKPDVDLTDGNFYASR-QA
Mvan_5217|M.vanbaalenii_PYR-1 ------------------------MTSTLP--ALDVDLADGNFYADGRAA
Mflv_1541|M.gilvum_PYR-GCK ------------------------MTSTVET-GLDVDLADGNFYADGTAA
MSMEG_5918|M.smegmatis_MC2_155 ------------------------MTQMLT--RPDVDLVNGMFYADG-GA
MAV_0641|M.avium_104 ------------------------MTSTIPEAIANIDLADGNFYADRRAS
TH_3500|M.thermoresistible__bu ------------------------MTSTAP----DIDLTDGRFYADSASA
MAB_3825|M.abscessus_ATCC_1997 -----------------------MATALSEIEEAGRVLADPAAYADELRL
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
Mb3547c|M.bovis_AF2122/97 --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv RAAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
MMAR_5003|M.marinum_M REAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
MUL_4077|M.ulcerans_Agy99 REAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
Mvan_5217|M.vanbaalenii_PYR-1 REAYKWMRANQPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
Mflv_1541|M.gilvum_PYR-GCK RAAYAWMRANQPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
MSMEG_5918|M.smegmatis_MC2_155 REAYRWMRANEPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
MAV_0641|M.avium_104 REAYRWMRANQPVFR----DRNGLAGATTYQAIQDAERNPELFSSTGG--
TH_3500|M.thermoresistible__bu RAAYRWMRQNQPVFR----DRNGLAAAATYQAIIESERNPELFSNTGG--
MAB_3825|M.abscessus_ATCC_1997 HAAMTLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLP----GMPLTVFSSFSDCDEALRHPLSASDRLKAT
Mb3547c|M.bovis_AF2122/97 --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv ------------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
MMAR_5003|M.marinum_M ------------IRPDQDALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
MUL_4077|M.ulcerans_Agy99 ------------IRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDK
Mvan_5217|M.vanbaalenii_PYR-1 ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDK
Mflv_1541|M.gilvum_PYR-GCK ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDK
MSMEG_5918|M.smegmatis_MC2_155 ------------IRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDK
MAV_0641|M.avium_104 ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNAGFTRKRVKEK
TH_3500|M.thermoresistible__bu ------------IRPEHPGMPYMIDMDDPEHLVRRKLVNHGFTRKRVRDR
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MLBr_02088|M.leprae_Br4923 LAQQAIAAG---AEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
Mb3547c|M.bovis_AF2122/97 --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv EASIAALCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVRPEQRDM
MMAR_5003|M.marinum_M ERSIAQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREM
MUL_4077|M.ulcerans_Agy99 EHSIAQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREM
Mvan_5217|M.vanbaalenii_PYR-1 VPSIENLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPDERDM
Mflv_1541|M.gilvum_PYR-GCK VPSIEKLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPEERDM
MSMEG_5918|M.smegmatis_MC2_155 VDSIGRLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPTERDM
MAV_0641|M.avium_104 EPSIGTLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPTERGM
TH_3500|M.thermoresistible__bu EDSIARLCDTLIDNVCERG-ECDFVRDIAAPLPMAVIGDMLGVAPEDRGQ
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPE
Mb3547c|M.bovis_AF2122/97 --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv FLRWSDDLVTFLSSHVS-----QEDFQITMDAFAAYNDFTRATIAARRAD
MMAR_5003|M.marinum_M FLRWSDDLVTFLSSHVS-----QEDFQVTIDAFAAYNDFTRATIAARRAE
MUL_4077|M.ulcerans_Agy99 FLRWSDDLVTFLSSQVS-----QEDFQVTIDAFAAYNDFTRATIAARRAE
Mvan_5217|M.vanbaalenii_PYR-1 LLKWSDDLVCGLSSTVD-----EQTIQKLMDTFAAYTAFTTEVIADRRAN
Mflv_1541|M.gilvum_PYR-GCK LLTWSDDLVCGLSSTVD-----EQTIQKLMDTFAAYTAFTMEVIADRRAN
MSMEG_5918|M.smegmatis_MC2_155 LLKWSDDLVCGLSSHVD-----EAAIQKLMDTFAAYTEFTKDVITKRRAE
MAV_0641|M.avium_104 LLKWSDDLVCGLSSHIDPT---SAEFQTVMDAFAAYTAFTMDIIAKRRAE
TH_3500|M.thermoresistible__bu LLKWSDDLVTGLSTTAD-----EATVQAVMDAFAGYTAYTMEIIGKRRAE
MAB_3825|M.abscessus_ATCC_1997 MLKLTQELFGGDDSEFQR----GTTPEEQLMALLDFFGYFSGLTASRRQH
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
Mb3547c|M.bovis_AF2122/97 ---------MSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQL
Rv3518c|M.tuberculosis_H37Rv PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQL
MMAR_5003|M.marinum_M PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQL
MUL_4077|M.ulcerans_Agy99 PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQL
Mvan_5217|M.vanbaalenii_PYR-1 PRDDLFSVLVNAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQL
Mflv_1541|M.gilvum_PYR-GCK PRDDLFSILVNAEVEGSRMSDDEIVFETLLILIGGDETTRHTLSGGTEQI
MSMEG_5918|M.smegmatis_MC2_155 PTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQL
MAV_0641|M.avium_104 PTDDLFSILVNAEVEGQRMSDDEIVMETLLILIGGDETTRHTLSGGTEQL
TH_3500|M.thermoresistible__bu PTDDLFSILINAEVEGQRMSDEEIVFETLLILIGGDETTRHTLSGGVEQL
MAB_3825|M.abscessus_ATCC_1997 PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
. .*. ::: : :: .*.:** ::.. :
Mb3547c|M.bovis_AF2122/97 LRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALC
Rv3518c|M.tuberculosis_H37Rv LRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALC
MMAR_5003|M.marinum_M LRNRDQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
MUL_4077|M.ulcerans_Agy99 LRNRVQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
Mvan_5217|M.vanbaalenii_PYR-1 LRHQDQWRQAVADPELLPGAIEEMLRWTSPVKNMCRTLTADTEFHGTSLK
Mflv_1541|M.gilvum_PYR-GCK LRHQDQWRQVVAQPDLLPSAIEEMLRWTSPVKNMCRTLTADTEFHGTALK
MSMEG_5918|M.smegmatis_MC2_155 LRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELR
MAV_0641|M.avium_104 LRHRDQWDALVRDPSLLPGAIEEMLRWTSPVKNMCRTLTADTEFHGTELR
TH_3500|M.thermoresistible__bu LRHPDQWQRLRNDPDLVPGAIEEMLRWTSPVKNMCRTLTADTEFHGTQLR
MAB_3825|M.abscessus_ATCC_1997 LEHPDQLARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPIT
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
*.: * : * .::* :*: ..:: : * : * : . :
Mb3547c|M.bovis_AF2122/97 AGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLA
Rv3518c|M.tuberculosis_H37Rv AGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLA
MMAR_5003|M.marinum_M EGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLA
MUL_4077|M.ulcerans_Agy99 KGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLA
Mvan_5217|M.vanbaalenii_PYR-1 AGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA
Mflv_1541|M.gilvum_PYR-GCK SGEKIMLMFESANFDESVFENPESFDIHRDPNSHVAFGFGTHFCLGNQLA
MSMEG_5918|M.smegmatis_MC2_155 AGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLA
MAV_0641|M.avium_104 AGEKIMLLFESGNFDESVFDDPDSFDIRRNPNSHMAFGFGTHFCLGNQLA
TH_3500|M.thermoresistible__bu KGEKMLLLFESANFDETVFENPDDFRIDRDPNPHIAFGFGTHFCLGNQLA
MAB_3825|M.abscessus_ATCC_1997 EGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFGVHFCLGAALA
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVGSHFCLGAALA
*:.::* :.* * :: * * * .. *:**..* ***:* **
Mb3547c|M.bovis_AF2122/97 RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPP
Rv3518c|M.tuberculosis_H37Rv RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPP
MMAR_5003|M.marinum_M RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
MUL_4077|M.ulcerans_Agy99 RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
Mvan_5217|M.vanbaalenii_PYR-1 RLELRLMLTKILQRLPDLRLAD-ESMLPLRPANFVSGLESMPVVFTPTAP
Mflv_1541|M.gilvum_PYR-GCK RLELKLMLGKILQRLPDMRLAD-ENMLPLRPANFVSGLESMPVVFTPTAK
MSMEG_5918|M.smegmatis_MC2_155 RLELRLMTERVLRRLPDLRLAD-DAPVPLRPANFVSGPESMPVVFTPSAP
MAV_0641|M.avium_104 RLELSMMTERVLKRLPDLRLAD-DGDLPLRPANFVSGLEAMPVVFTPSAP
TH_3500|M.thermoresistible__bu RLELTLMLRRLLQRLPDLRLAS-DDPLPLRPANFVSGPEAMPVVFTPTEP
MAB_3825|M.abscessus_ATCC_1997 RMEVNSFFSALLPRLESIEVDG---NIERTSTIFVGGIKHLPIRYTLR--
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAG---ELVYKPNVAMRGMSALPVQV-----
*:* : *: .:.: : . : * . :*:
Mb3547c|M.bovis_AF2122/97 LG-
Rv3518c|M.tuberculosis_H37Rv LG-
MMAR_5003|M.marinum_M LS-
MUL_4077|M.ulcerans_Agy99 LR-
Mvan_5217|M.vanbaalenii_PYR-1 VGA
Mflv_1541|M.gilvum_PYR-GCK VLS
MSMEG_5918|M.smegmatis_MC2_155 VLA
MAV_0641|M.avium_104 LLR
TH_3500|M.thermoresistible__bu VSA
MAB_3825|M.abscessus_ATCC_1997 ---
MLBr_02088|M.leprae_Br4923 ---