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TKPLIKPDVDLTDGNFYASRQAREAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAGGIRPD QDALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKERSIAQLCDTLIDAVCERGECDFVRDLAAPLPMAVI GDMLGVLPEQREMFLRWSDDLVTFLSSHVSQEDFQVTIDAFAAYNDFTRATIAARRAEPTDDLVSVLVSS EVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQLLRNRDQWDLLQSDRELLPGAIEEMLRWTAPVK NMCRMLTADTEFHGTALSEGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLARL ELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRPLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5003 | cyp142A3 | - | 100% (401) | cytochrome P450 142A3 Cyp142A3 |
| M. marinum M | MMAR_4833 | cyp123B1 | 1e-60 | 39.36% (376) | cytochrome P450 123B1 Cyp123B1 |
| M. marinum M | MMAR_3999 | cyp108B4 | 1e-54 | 34.15% (366) | cytochrome P450 108B4 Cyp108B4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3548c | cyp142a | 1e-104 | 94.30% (193) | cytochrome P450 monooxygenase |
| M. gilvum PYR-GCK | Mflv_1541 | - | 1e-173 | 75.90% (390) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 0.0 | 92.11% (393) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-46 | 33.03% (333) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 2e-56 | 34.76% (351) | cytochrome P450 |
| M. avium 104 | MAV_0641 | - | 0.0 | 78.36% (402) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_5918 | - | 0.0 | 77.50% (400) | P450 heme-thiolate protein |
| M. thermoresistible (build 8) | TH_3500 | - | 1e-169 | 72.66% (395) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_4077 | cyp142A3 | 0.0 | 98.75% (400) | cytochrome P450 142A3 Cyp142A3 |
| M. vanbaalenii PYR-1 | Mvan_5217 | - | 1e-179 | 76.81% (401) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5003|M.marinum_M ------------------------MTKPLI--KPDVDLTDGNFYASR-QA
MUL_4077|M.ulcerans_Agy99 ----------------------MAMTKPLI--KPDVDLTDGNFYASR-QA
Mb3548c|M.bovis_AF2122/97 ------------------------MTE-----APDVDLADGNFYASR-EA
Rv3518c|M.tuberculosis_H37Rv ------------------------MTE-----APDVDLADGNFYASR-EA
Mflv_1541|M.gilvum_PYR-GCK ------------------------MTSTVET-GLDVDLADGNFYADGTAA
Mvan_5217|M.vanbaalenii_PYR-1 ------------------------MTSTLP--ALDVDLADGNFYADGRAA
MSMEG_5918|M.smegmatis_MC2_155 ------------------------MTQMLT--RPDVDLVNGMFYADG-GA
MAV_0641|M.avium_104 ------------------------MTSTIPEAIANIDLADGNFYADRRAS
TH_3500|M.thermoresistible__bu ------------------------MTST----APDIDLTDGRFYADSASA
MAB_3825|M.abscessus_ATCC_1997 -----------------------MATALSEIEEAGRVLADPAAYADELRL
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
* * .
MMAR_5003|M.marinum_M REAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
MUL_4077|M.ulcerans_Agy99 REAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
Mb3548c|M.bovis_AF2122/97 RAAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
Rv3518c|M.tuberculosis_H37Rv RAAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
Mflv_1541|M.gilvum_PYR-GCK RAAYAWMRANQPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
Mvan_5217|M.vanbaalenii_PYR-1 REAYKWMRANQPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
MSMEG_5918|M.smegmatis_MC2_155 REAYRWMRANEPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
MAV_0641|M.avium_104 REAYRWMRANQPVFR----DRNGLAGATTYQAIQDAERNPELFSSTGG--
TH_3500|M.thermoresistible__bu RAAYRWMRQNQPVFR----DRNGLAAAATYQAIIESERNPELFSNTGG--
MAB_3825|M.abscessus_ATCC_1997 HAAMTLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLP----GMPLTVFSSFSDCDEALRHPLSASDRLKAT
. : *: : :... *. .
MMAR_5003|M.marinum_M ------------IRPDQDALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
MUL_4077|M.ulcerans_Agy99 ------------IRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDK
Mb3548c|M.bovis_AF2122/97 ------------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
Rv3518c|M.tuberculosis_H37Rv ------------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
Mflv_1541|M.gilvum_PYR-GCK ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDK
Mvan_5217|M.vanbaalenii_PYR-1 ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDK
MSMEG_5918|M.smegmatis_MC2_155 ------------IRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDK
MAV_0641|M.avium_104 ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNAGFTRKRVKEK
TH_3500|M.thermoresistible__bu ------------IRPEHPGMPYMIDMDDPEHLVRRKLVNHGFTRKRVRDR
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MLBr_02088|M.leprae_Br4923 LAQQAIAAG---AEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
. :: :* * * * : * * :
MMAR_5003|M.marinum_M ERSIAQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREM
MUL_4077|M.ulcerans_Agy99 EHSIAQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREM
Mb3548c|M.bovis_AF2122/97 EASIAALCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVRPEQRDM
Rv3518c|M.tuberculosis_H37Rv EASIAALCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVRPEQRDM
Mflv_1541|M.gilvum_PYR-GCK VPSIEKLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPEERDM
Mvan_5217|M.vanbaalenii_PYR-1 VPSIENLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPDERDM
MSMEG_5918|M.smegmatis_MC2_155 VDSIGRLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPTERDM
MAV_0641|M.avium_104 EPSIGTLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPTERGM
TH_3500|M.thermoresistible__bu EDSIARLCDTLIDNVCERG-ECDFVRDIAAPLPMAVIGDMLGVAPEDRGQ
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPE
* : :: * . *. *:* :.: ** :**: :
MMAR_5003|M.marinum_M FLRWSDDLVTFLSSHVS-----QEDFQVTIDAFAAYNDFTRATIAARRAE
MUL_4077|M.ulcerans_Agy99 FLRWSDDLVTFLSSQVS-----QEDFQVTIDAFAAYNDFTRATIAARRAE
Mb3548c|M.bovis_AF2122/97 FLRWSDDLVTFLSSHVS-----QEDFQITMDAFAAYNDFTRATIAARRAD
Rv3518c|M.tuberculosis_H37Rv FLRWSDDLVTFLSSHVS-----QEDFQITMDAFAAYNDFTRATIAARRAD
Mflv_1541|M.gilvum_PYR-GCK LLTWSDDLVCGLSSTVD-----EQTIQKLMDTFAAYTAFTMEVIADRRAN
Mvan_5217|M.vanbaalenii_PYR-1 LLKWSDDLVCGLSSTVD-----EQTIQKLMDTFAAYTAFTTEVIADRRAN
MSMEG_5918|M.smegmatis_MC2_155 LLKWSDDLVCGLSSHVD-----EAAIQKLMDTFAAYTEFTKDVITKRRAE
MAV_0641|M.avium_104 LLKWSDDLVCGLSSHIDPT---SAEFQTVMDAFAAYTAFTMDIIAKRRAE
TH_3500|M.thermoresistible__bu LLKWSDDLVTGLSTTAD-----EATVQAVMDAFAGYTAYTMEIIGKRRAE
MAB_3825|M.abscessus_ATCC_1997 MLKLTQELFGGDDSEFQR----GTTPEEQLMALLDFFGYFSGLTASRRQH
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
: : *. .. : : : : **
MMAR_5003|M.marinum_M PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQL
MUL_4077|M.ulcerans_Agy99 PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQL
Mb3548c|M.bovis_AF2122/97 PPTTWSACW-----------------------------------------
Rv3518c|M.tuberculosis_H37Rv PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQL
Mflv_1541|M.gilvum_PYR-GCK PRDDLFSILVNAEVEGSRMSDDEIVFETLLILIGGDETTRHTLSGGTEQI
Mvan_5217|M.vanbaalenii_PYR-1 PRDDLFSVLVNAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQL
MSMEG_5918|M.smegmatis_MC2_155 PTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQL
MAV_0641|M.avium_104 PTDDLFSILVNAEVEGQRMSDDEIVMETLLILIGGDETTRHTLSGGTEQL
TH_3500|M.thermoresistible__bu PTDDLFSILINAEVEGQRMSDEEIVFETLLILIGGDETTRHTLSGGVEQL
MAB_3825|M.abscessus_ATCC_1997 PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
* :
MMAR_5003|M.marinum_M LRNRDQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
MUL_4077|M.ulcerans_Agy99 LRNRVQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
Mb3548c|M.bovis_AF2122/97 --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv LRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALC
Mflv_1541|M.gilvum_PYR-GCK LRHQDQWRQVVAQPDLLPSAIEEMLRWTSPVKNMCRTLTADTEFHGTALK
Mvan_5217|M.vanbaalenii_PYR-1 LRHQDQWRQAVADPELLPGAIEEMLRWTSPVKNMCRTLTADTEFHGTSLK
MSMEG_5918|M.smegmatis_MC2_155 LRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELR
MAV_0641|M.avium_104 LRHRDQWDALVRDPSLLPGAIEEMLRWTSPVKNMCRTLTADTEFHGTELR
TH_3500|M.thermoresistible__bu LRHPDQWQRLRNDPDLVPGAIEEMLRWTSPVKNMCRTLTADTEFHGTQLR
MAB_3825|M.abscessus_ATCC_1997 LEHPDQLARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPIT
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
MMAR_5003|M.marinum_M EGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLA
MUL_4077|M.ulcerans_Agy99 KGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLA
Mb3548c|M.bovis_AF2122/97 --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv AGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLA
Mflv_1541|M.gilvum_PYR-GCK SGEKIMLMFESANFDESVFENPESFDIHRDPNSHVAFGFGTHFCLGNQLA
Mvan_5217|M.vanbaalenii_PYR-1 AGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA
MSMEG_5918|M.smegmatis_MC2_155 AGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLA
MAV_0641|M.avium_104 AGEKIMLLFESGNFDESVFDDPDSFDIRRNPNSHMAFGFGTHFCLGNQLA
TH_3500|M.thermoresistible__bu KGEKMLLLFESANFDETVFENPDDFRIDRDPNPHIAFGFGTHFCLGNQLA
MAB_3825|M.abscessus_ATCC_1997 EGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFGVHFCLGAALA
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVGSHFCLGAALA
MMAR_5003|M.marinum_M RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
MUL_4077|M.ulcerans_Agy99 RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
Mb3548c|M.bovis_AF2122/97 --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPP
Mflv_1541|M.gilvum_PYR-GCK RLELKLMLGKILQRLPDMRLAD-ENMLPLRPANFVSGLESMPVVFTPTAK
Mvan_5217|M.vanbaalenii_PYR-1 RLELRLMLTKILQRLPDLRLAD-ESMLPLRPANFVSGLESMPVVFTPTAP
MSMEG_5918|M.smegmatis_MC2_155 RLELRLMTERVLRRLPDLRLAD-DAPVPLRPANFVSGPESMPVVFTPSAP
MAV_0641|M.avium_104 RLELSMMTERVLKRLPDLRLAD-DGDLPLRPANFVSGLEAMPVVFTPSAP
TH_3500|M.thermoresistible__bu RLELTLMLRRLLQRLPDLRLAS-DDPLPLRPANFVSGPEAMPVVFTPTEP
MAB_3825|M.abscessus_ATCC_1997 RMEVNSFFSALLPRLESIEVDG---NIERTSTIFVGGIKHLPIRYTLR--
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAG---ELVYKPNVAMRGMSALPVQV-----
MMAR_5003|M.marinum_M LS-
MUL_4077|M.ulcerans_Agy99 LR-
Mb3548c|M.bovis_AF2122/97 ---
Rv3518c|M.tuberculosis_H37Rv LG-
Mflv_1541|M.gilvum_PYR-GCK VLS
Mvan_5217|M.vanbaalenii_PYR-1 VGA
MSMEG_5918|M.smegmatis_MC2_155 VLA
MAV_0641|M.avium_104 LLR
TH_3500|M.thermoresistible__bu VSA
MAB_3825|M.abscessus_ATCC_1997 ---
MLBr_02088|M.leprae_Br4923 ---