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TIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAADRPTILMLHGGGQNRFSWKNTGQI LADEGHHVVALDTRGPGDSDRAPGADYAVETPTTDVLHVVEAIGRRVVVVEASMGGLTGILVAERAGPQT VNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPHRDKPRSPEGLKRNLRLRDGRWH WHWDPAMMTAPGHDPQLRTENFERAAMGLTIPVLLIRGKLSDVVSSDGARDFLAKVPNAEFVELSNAGRT AAGDDNDAFTDVVVDFVRRLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1123c | bpoB | - | 100% (302) | POSSIBLE PEROXIDASE BPOB (NON-HAEM PEROXIDASE) |
| M. tuberculosis H37Rv | Rv3473c | bpoA | 4e-52 | 38.67% (256) | peroxidase BpoA |
| M. tuberculosis H37Rv | Rv0045c | - | 1e-13 | 26.79% (280) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1154c | bpoB | 1e-175 | 100.00% (302) | peroxidase BpoB |
| M. gilvum PYR-GCK | Mflv_2096 | - | 1e-108 | 66.21% (290) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_02297 | - | 3e-05 | 20.57% (282) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 1e-54 | 42.23% (296) | putative hydrolase (alpha/beta fold) |
| M. marinum M | MMAR_4337 | bpoB | 1e-134 | 80.07% (286) | peroxidase BpoB |
| M. avium 104 | MAV_1254 | - | 1e-121 | 75.72% (276) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 1e-111 | 67.25% (287) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 1e-100 | 66.42% (268) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 1e-132 | 79.02% (286) | peroxidase BpoB |
| M. vanbaalenii PYR-1 | Mvan_4609 | - | 1e-108 | 64.97% (294) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1123c|M.tuberculosis_H37Rv MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAAD--
Mb1154c|M.bovis_AF2122/97 MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAAD--
MMAR_4337|M.marinum_M --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASG--
MUL_0147|M.ulcerans_Agy99 --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASG--
MAV_1254|M.avium_104 ------------------------MEFAGVDGITLVADEWNRGSDGAG--
Mflv_2096|M.gilvum_PYR-GCK --------------MSIEHREPKTVTFRGADGLALVADEWNNPAQTEA--
Mvan_4609|M.vanbaalenii_PYR-1 --------------MSTVSSEPTTVTFRGAEDLALVADEWNNPAEAASSG
MSMEG_5209|M.smegmatis_MC2_155 --------------MSTAQTESQTVAFRGVDDLTLVGDEWNKGAERAA--
TH_2112|M.thermoresistible__bu --------------LNSTHSKPQTVRFRGAQGLTLVADQWNRGSGPKD--
MAB_2045|M.abscessus_ATCC_1997 ----------MSAKRTGDSSAPVVERVPTADGLALAVDLYHCDAP-----
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSATA--
. . :. . .
Rv1123c|M.tuberculosis_H37Rv ------RPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDR
Mb1154c|M.bovis_AF2122/97 ------RPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDR
MMAR_4337|M.marinum_M ------RPTILMLHGGGQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR
MUL_0147|M.ulcerans_Agy99 ------RPTILMLHGGCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR
MAV_1254|M.avium_104 ------RPSILMLHGGGQNRFSWKNTGQTLADEGLHVVALDSRGHGDSDR
Mflv_2096|M.gilvum_PYR-GCK --FDRSRPSVLMMHGGGQNRFSWKKTGQILGEQGLHVVALDSRGHGDSDR
Mvan_4609|M.vanbaalenii_PYR-1 RDFDASRPSVLMLHGGGQNRFSWKKTGQTLASQGLHVVALDSRGHGDSDR
MSMEG_5209|M.smegmatis_MC2_155 -----DRPTVLLLHGGGQNRYSWKNTGQILADQGFHVIALDARGHGDSDR
TH_2112|M.thermoresistible__bu ------RPTILLLHGGGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDR
MAB_2045|M.abscessus_ATCC_1997 ------RAVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDW
MLBr_02297|M.leprae_Br4923 ------RPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDK
*. ::::** . :* : * . : * * ** *.**
Rv1123c|M.tuberculosis_H37Rv APGADYAVETPTTDVLHV--VEAIGRRVVVVEASMGGLTGILVAERAGPQ
Mb1154c|M.bovis_AF2122/97 APGADYAVETPTTDVLHV--VEAIGRRVVVVEASMGGLTGILVAERAGPQ
MMAR_4337|M.marinum_M APDADYAIETLTSDILHV--LDAIGRPVVLIGASMGGLTGILVADSAGPD
MUL_0147|M.ulcerans_Agy99 APDADYAIETLTSDIRHV--LDAIGRPVVLIGASMGGLTGILVADSAGPD
MAV_1254|M.avium_104 SPQADYQIETLTADVLRV--LDAIGRPVTIIGASMGGLTGILAAHRAGPA
Mflv_2096|M.gilvum_PYR-GCK SPDARYTVEALCEDTLRV--LEQIGRPTVLIGASMGGLTGILAARRAGPE
Mvan_4609|M.vanbaalenii_PYR-1 SPDANYTVEALCADTLAV--LRQIGRPTVLIGASMGGLTGILASRQAGPE
MSMEG_5209|M.smegmatis_MC2_155 SPSANYSVDAMCGDVLAV--LYQISRPVALIGASMGGLTGLLAAHEAGPE
TH_2112|M.thermoresistible__bu SPTADYQLDDLCADTLSV--VDQIGRPVSLIGASMGGLTGILVADRAGAD
MAB_2045|M.abscessus_ATCC_1997 DPDGRYDMDRLGSDLLAVRSYADSGRPVAAIGASLGGLTILGTHLLAPPD
MLBr_02297|M.leprae_Br4923 PPRG-YDGWTLAGDTAGL--IRALGHSSATLVGHAEGGLACWATALLHPR
* . * * : .: : . * . .
Rv1123c|M.tuberculosis_H37Rv TVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPHR
Mb1154c|M.bovis_AF2122/97 TVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPHR
MMAR_4337|M.marinum_M RVTGLVLVDVVPKYEKDGSARIRDFMFTNLHGFATLEEAADAVATYLPHR
MUL_0147|M.ulcerans_Agy99 RVTGLVLVDVVPKYEKDGSARIRDFMFTNLHGFATLEEAADAVATYLPHR
MAV_1254|M.avium_104 KVTRLVLVDVVPRFEKDGSARIRDFMISGLDGFDSLEQAADAVAAYLPYR
Mflv_2096|M.gilvum_PYR-GCK VVTRLVLVDVVPRYEKGGSARIRDFMFSHVHGFDSLEQAADAVAEYLPHR
Mvan_4609|M.vanbaalenii_PYR-1 LVTRLILVDVVPRYEKDGSARIREFMFSHVHGFESLEQAAEAVAAYLPHR
MSMEG_5209|M.smegmatis_MC2_155 RVTQLVLVDVVPNFEKSGSARIRDFMASNVDGFDTLEEAADAVAAYLPHR
TH_2112|M.thermoresistible__bu KVTELVLVDVVPRVEQAGTDRIRDFMMTNVAGFETLEEAADAVAAYLPHR
MAB_2045|M.abscessus_ATCC_1997 LWQAVVLVDVTPRMEMDGARRVVAFMSAHPEGFDSLESAADVIAAYNPHR
MLBr_02297|M.leprae_Br4923 LVRAIALINSP-----HPAALRRSMLTHRNQGYALLPTLLRYQLPIWPER
: *:: :: *: * * *
Rv1123c|M.tuberculosis_H37Rv DKPRS-PEGLKRNLRLR-DGRWHWHWDPAMMT----APGHDPQLRTENFE
Mb1154c|M.bovis_AF2122/97 DKPRS-PEGLKRNLRLR-DGRWHWHWDPAMMT----APGHDPQLRTENFE
MMAR_4337|M.marinum_M TKPRS-PEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFE
MUL_0147|M.ulcerans_Agy99 TKPRS-PEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFE
MAV_1254|M.avium_104 SKPRS-PEGLKKNLRLR-DGRWYWHWDPAFMT----KPGDDPELRTESFE
Mflv_2096|M.gilvum_PYR-GCK AKPRS-PEGLKKNLRRR-NGRWYWHWDPAFLT----KPSEDPFARVEQLE
Mvan_4609|M.vanbaalenii_PYR-1 TKPRS-PEGLKKNLRHR-HGRWYWHWDPAFLT----KPNEDPFVRVEQLE
MSMEG_5209|M.smegmatis_MC2_155 RRPRN-PEGLKKNLRLR-DGRWYWHWDPAFLG----KPHDDPFVRVERLE
TH_2112|M.thermoresistible__bu RRPRS-PEGLKKNLRHR-DGRWHWHWDPAFVT----RVG-EQFVDVDVLE
MAB_2045|M.abscessus_ATCC_1997 PRPEN-LDGLRKVLARREDGRWSWRWDPAFVTSNFQFLQGDPDEGAEYFE
MLBr_02297|M.leprae_Br4923 LLTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALE
... :.: : * .:* * *. :*
Rv1123c|M.tuberculosis_H37Rv RA-------------------AMGLTIPVLLIRGKLSDVVSSDGARDFLA
Mb1154c|M.bovis_AF2122/97 RA-------------------AMGLTIPVLLIRGKLSDVVSSDGARDFLA
MMAR_4337|M.marinum_M RA-------------------AMNLTIPILLIRGKLSDVVSSEGVQDFLD
MUL_0147|M.ulcerans_Agy99 RA-------------------AMNLTIPILLIRGKLSDVVTSEGVQDFLD
MAV_1254|M.avium_104 QA-------------------AKNLSIPVLLIRGKLSDVVSPEGVRHFLA
Mflv_2096|M.gilvum_PYR-GCK QA-------------------ATELTVPILLIRGKLSDVVSEEAVQDFLA
Mvan_4609|M.vanbaalenii_PYR-1 QA-------------------AIELTIPILLIRGKLSDVVSEEAVQDFLT
MSMEG_5209|M.smegmatis_MC2_155 QA-------------------AVNLTVPILLIRGKLSDVVSPEGVAEFLE
TH_2112|M.thermoresistible__bu RA-------------------ALRLTVPILLVRGKLSDVVSAEGVEEFLA
MAB_2045|M.abscessus_ATCC_1997 MMSAFL------------LDGARQVSAPTLLVRGLLSDIVSEETVRHFLT
MLBr_02297|M.leprae_Br4923 YQRWAVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRR
: .: * * :** . : : .
Rv1123c|M.tuberculosis_H37Rv KVPNAEFVELSNAGRTAAGDDNDAFTDVVVDFVRRLS-------------
Mb1154c|M.bovis_AF2122/97 KVPNAEFVELSNAGRTAAGDDNDAFTDVVVDFVRRLS-------------
MMAR_4337|M.marinum_M KVPHAEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------
MUL_0147|M.ulcerans_Agy99 KVPHAEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------
MAV_1254|M.avium_104 TVPRAEFVELSNAGHTAAGDDNDAFSDAVVAFVKRR--------------
Mflv_2096|M.gilvum_PYR-GCK KVPGAEFAELSGAGHTAAGDDNDAFSEVVTRFVLR---------------
Mvan_4609|M.vanbaalenii_PYR-1 KVPNAEFVELPGAGHTAAGDDNDAFSEVVAQFVLR---------------
MSMEG_5209|M.smegmatis_MC2_155 KVPAAEFVELSDAGHTAAGDDNDAFTQVVVEFVNR---------------
TH_2112|M.thermoresistible__bu KVPSAEFVELSAAXXXATIPARGSPRRCVTSPVCRRRPPTSRPAPSPRSA
MAB_2045|M.abscessus_ATCC_1997 VVPHAQTVDVSGAGHMIAGDNNDAFSTAVVEFLDRTI-------------
MLBr_02297|M.leprae_Br4923 YAPHGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS--------
.* .. ..:. * :. : :
Rv1123c|M.tuberculosis_H37Rv ----------------
Mb1154c|M.bovis_AF2122/97 ----------------
MMAR_4337|M.marinum_M ----------------
MUL_0147|M.ulcerans_Agy99 ----------------
MAV_1254|M.avium_104 ----------------
Mflv_2096|M.gilvum_PYR-GCK ----------------
Mvan_4609|M.vanbaalenii_PYR-1 ----------------
MSMEG_5209|M.smegmatis_MC2_155 ----------------
TH_2112|M.thermoresistible__bu PRHGNVAGPGANAVRR
MAB_2045|M.abscessus_ATCC_1997 ----------------
MLBr_02297|M.leprae_Br4923 ----------------