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TGPPPSLPERIRTDEADVLMLPDGRALAYLEWGDSTGYPAFYFHGTPSSRLEGAFADGAARRTGFRLIAI DRPGYGRSTFQAGRNFRDWPADVCALADAFELEEFGVVGHSGAGPHLFACGAVIPRTRLAFVGALGPWGP LATPDIMRSLNAADRCYARLARSGPRLFGALFAPLGWCAKYTPGLFSTLLAAAVPAADKHLLSDERFGRH LRAIQLEAFRQGSRGAAYESFLQFRPWGFDLAEVAVPTHIWLGDRDSFVPRAMGEYLQRAIPHVDLHWAH GKGHFNIEDWDAILAACALDIGKRRGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3312c | - | - | 100% (308) | hypothetical protein Rv3312c |
| M. tuberculosis H37Rv | Rv1191 | - | 2e-26 | 32.96% (270) | hypothetical protein Rv1191 |
| M. tuberculosis H37Rv | Rv1938 | ephB | 6e-06 | 28.70% (108) | epoxide hydrolase EphB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3340c | - | 0.0 | 100.00% (308) | hypothetical protein Mb3340c |
| M. gilvum PYR-GCK | Mflv_0111 | - | 3e-29 | 32.76% (290) | alpha/beta hydrolase fold |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3556 | - | 7e-06 | 30.00% (120) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_1214 | - | 1e-140 | 77.70% (296) | hypothetical protein MMAR_1214 |
| M. avium 104 | MAV_1342 | - | 3e-27 | 32.96% (270) | hydrolase, alpha/beta hydrolase fold family protein |
| M. smegmatis MC2 155 | MSMEG_3508 | - | 6e-27 | 32.95% (258) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_2940 | - | 2e-29 | 33.58% (268) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_2678 | - | 1e-138 | 77.03% (296) | hypothetical protein MUL_2678 |
| M. vanbaalenii PYR-1 | Mvan_0797 | - | 1e-27 | 31.52% (276) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3312c|M.tuberculosis_H37Rv ----MTGPPPSLPERIRTDEADVLMLPDGRALAYLEWGDSTGYPAFYFHG
Mb3340c|M.bovis_AF2122/97 ----MTGPPPSLPERIRTDEADVLMLPDGRALAYLEWGDSTGYPAFYFHG
MMAR_1214|M.marinum_M --------MQTLPEDIRADEANVVTLPDGRELACLEWGDPTGYPTFYFHG
MUL_2678|M.ulcerans_Agy99 --------MQTLPEDIRADEANVVTLPDGRELACLEWGDPTGYPTFYFHG
Mflv_0111|M.gilvum_PYR-GCK MISNPWRHPPGVPRCEAPRAEGTFFLPDGRRLGYAEFGDPTGDVVLWFHG
Mvan_0797|M.vanbaalenii_PYR-1 MLSNPWRHPPGVPRCEPPRAEGAFFLPDGRRIGYAEYGDPSGPVVLWFHG
TH_2940|M.thermoresistible__bu -----------VPPTEKPRAEGRVHLPTGRRLGFAEFGDPAGVPVVWLHG
MAV_1342|M.avium_104 ----------MAIEIARPKLEGNVAVGEDRQIGFAEFGDPQGRAMFWLHG
MSMEG_3508|M.smegmatis_MC2_155 --------MAMVIPIDRPKLEGNVAVGDDRRLGFAEFGDPQGRAIFWLHG
MAB_3556|M.abscessus_ATCC_1997 -------------MGNTLTVQTALLDVEVRRHGNPENTDK--LPVVLLHG
. * . * * . :**
Rv3312c|M.tuberculosis_H37Rv TPSSRLEGAFADG-AARRTGFRLIAIDRPGYGRSTFQAGRN-----FRDW
Mb3340c|M.bovis_AF2122/97 TPSSRLEGAFADG-AARRTGFRLIAIDRPGYGRSTFQAGRN-----FRDW
MMAR_1214|M.marinum_M TPSSRLEGAFADG-AARRARFRLIAVDRPGYGRSTFQEGRT-----LRDW
MUL_2678|M.ulcerans_Agy99 TLSSRLEGAFADG-AARRARFRLIAVDRPGYGRSTFQEGRT-----LRDW
Mflv_0111|M.gilvum_PYR-GCK TPGGRRQLPIVGRRAAERLGLRVVLVERAGAGLSSAHRYDR-----IGDW
Mvan_0797|M.vanbaalenii_PYR-1 TPGGRRQLPIVGRRAAEKLGLRVVLVERAGSGLSHRHCYDR-----VGDW
TH_2940|M.thermoresistible__bu TPGGRRQFPLTGRRAAEQLGLRVVLLERPGAGLSDPYRYRS-----VADW
MAV_1342|M.avium_104 TPGARRQIPVEARLYAENHKIRLIGLDRPGIGSSTPHRYQN-----IRAF
MSMEG_3508|M.smegmatis_MC2_155 TPGARRQIPTEARAYAEQNGVRLIGVDRPGIGSSTPHQYEC-----VLDF
MAB_3556|M.abscessus_ATCC_1997 WPDSVATWTHVIP-ALASAGHQVYAPSVRGTGQTKFRYADTPRTGRLGDL
.. . :: . * * : .
Rv3312c|M.tuberculosis_H37Rv PADVCALADAFELEEFGVVGHSGAGPHLFACG-AVIPRTRLAFVGALGPW
Mb3340c|M.bovis_AF2122/97 PADVCALADAFELEEFGVVGHSGAGPHLFACG-AVIPRTRLAFVGALGPW
MMAR_1214|M.marinum_M PADVCALADALGLDKFGVVGHSGAGPHLFACG-ARIAPSRLAFIGALGPW
MUL_2678|M.ulcerans_Agy99 PADVCALADALGLDKFGVVGHSGAGTHLFACG-ARIALSRLAFIGALGPW
Mflv_0111|M.gilvum_PYR-GCK ADDMAHVADALGADKLGVAGLSGGGPYALACAGMPALRDRVAAVAVLGGV
Mvan_0797|M.vanbaalenii_PYR-1 ATDMAHVADLLGAEKLGVVGLSGGGPFALACAGMPALADRVVAVAVLGGV
TH_2940|M.thermoresistible__bu VTDVTYVADAIGAERLAVVGLSGGGPYALACGAVAPLAERVRSIAVLGGV
MAV_1342|M.avium_104 GEDLRTIADTLGIDKMAVIGLSGGGPYALASA--AVLPDRVVAAGILGGV
MSMEG_3508|M.smegmatis_MC2_155 ASDLRTIADTLGIDKLAVIGLSGGGPYTLACA--AAMPDRVVAAGVLGGV
MAB_3556|M.abscessus_ATCC_1997 LRDLFAVCDQLKLERFHLVGHDWGARTAFACG--IVAPHRIASLSAISAG
*: :.* : :.: : * . .. :*.. *: . :.
Rv3312c|M.tuberculosis_H37Rv GPLATPDIMRS-LNAADRCYARLARSGPRLFGALFAPLGWCAKYTPGLFS
Mb3340c|M.bovis_AF2122/97 GPLATPDIMRS-LNAADRCYARLARSGPRLFGALFAPLGWCAKYTPGLFS
MMAR_1214|M.marinum_M GPLATPEIMGS-LNLADRSYARLAQHGPRLFHALFAPLGWCAKYAPGLFT
MUL_2678|M.ulcerans_Agy99 GPLATPEIMGS-LNLADRSYARLAQHGPRLFHALFAPLGWCAKYAPGLFT
Mflv_0111|M.gilvum_PYR-GCK TPSVGPDATASGAITLARQLSAVTSALRRPFAAVTAGLLTPVIPLAHLAY
Mvan_0797|M.vanbaalenii_PYR-1 TPSVGPDAACSGAITLSRKFAPVTSAMRRPFAAVTAGLLTPVIPLAHLAY
TH_2940|M.thermoresistible__bu TPSVGPDASATGAIELARRFTSLLGTLRGPLATTLAGLVTPVLPFAHFAC
MAV_1342|M.avium_104 APFLGDEGITSGLMNLGKRVAPLLKLGGDPLRIGASLVVRAIRPVANPAL
MSMEG_3508|M.smegmatis_MC2_155 APMVGPDAISSPLMQLGAVVAPVLQVAGGPIRLVASGMIRLIRPVASPAL
MAB_3556|M.abscessus_ATCC_1997 WHPAGHGPALSSLQAQRFWYQWLLNTPAG-----ADLLRRERRELVELIW
: : :
Rv3312c|M.tuberculosis_H37Rv TLLAAAVPAADKHLLSDERFGRHLRAIQLEAFRQGSRGAAYESFLQFRPW
Mb3340c|M.bovis_AF2122/97 TLLAAAVPAADKHLLSDERFGRHLRAIQLEAFRQGSRGAAYESFLQFRPW
MMAR_1214|M.marinum_M KLITASVPAVDKHRMRDKRFVQHFQAVQLEAFRQGSRGAAYEAFLEYRPW
MUL_2678|M.ulcerans_Agy99 KLITASVPAVDKHRMRDKRFVQHFQAVQLEAFRQGSRGAAYEAFLEYRPW
Mflv_0111|M.gilvum_PYR-GCK SGLAAVMPDGDKRVFANPEIEAMFIDDIVQVANGRFQALLDDARLFGVDW
Mvan_0797|M.vanbaalenii_PYR-1 RGLSAAMPEGDKRVFANPEIEAMFIDDIVHAANGGFQALLDDARLFGRDW
TH_2940|M.thermoresistible__bu QAYASISPESDRRVLHDPEMEAMFIDDLVLAARGGLRAIVDDARLFGRDW
MAV_1342|M.avium_104 YLYAAISPEGDRRLLTRPEFGAMFLDDLLNGSRKQLAAPFNDIILFTQDW
MSMEG_3508|M.smegmatis_MC2_155 EIYARLSPEGDRRMLGRPEFKAMFLDDLLNGSRKQLAAPFYDIVVFERDW
MAB_3556|M.abscessus_ATCC_1997 RDWSPNWKFSDQ--EFDDTFTSLQSSDWLEVTLSYYRARWGWGPVIDDPF
: *: : : . : :
Rv3312c|M.tuberculosis_H37Rv GFDLAE---VAVPTHIWLGDRDSFVPRAMGEYLQRAIPH-VDLHWAHGKG
Mb3340c|M.bovis_AF2122/97 GFDLAE---VAVPTHIWLGDRDSFVPRAMGEYLQRAIPH-VDLHWAHGKG
MMAR_1214|M.marinum_M EFDPSE---VDVPTHIWLGTHDSFVPREMGEYLERVIPN-VELHWAAGKG
MUL_2678|M.ulcerans_Agy99 EFDPSE---VDVPTHIWLGTHDSFVPREMGEYLERVIPN-VELHWAAGKG
Mflv_0111|M.gilvum_PYR-GCK GFRLAD---VAVPVRWWHGDADSIISLADAQAAAEHLPD-VDLLLMPDES
Mvan_0797|M.vanbaalenii_PYR-1 GFRLAD---VKVPVRWWHGDADSIISLADAQAATEHLPD-VELLLMPDES
TH_2940|M.thermoresistible__bu GFRLAD---VRAPVRWWHGDSDHIVTLTDAQKAVERLPD-AELVLRLEES
MAV_1342|M.avium_104 GFRLDQ---VKVPVRWWHGDSDHIVPFAHGQHVVSLLPD-AELFVLPGES
MSMEG_3508|M.smegmatis_MC2_155 GFRLDE---VTVPVRWWHGDHDHIVPFAHGQHVVSRLQD-AKLTELPYES
MAB_3556|M.abscessus_ATCC_1997 EKQIAQATAISVPSLVLHGDSDNCVLPIASEGMNQHFPHGFSRLTTPGVG
: : .* * * : .: : . . .
Rv3312c|M.tuberculosis_H37Rv HFN-IEDWDAILAACALDIGKRRGG-----
Mb3340c|M.bovis_AF2122/97 HFN-IEDWDAILAACALDIGKRRGG-----
MMAR_1214|M.marinum_M HFN-VEDWDAIFAACAADI-----------
MUL_2678|M.ulcerans_Agy99 HFN-VEDWDAIFAACAADI-----------
Mflv_0111|M.gilvum_PYR-GCK HLGGFAKADDVLAFLAPHLRHDDEQHRRKV
Mvan_0797|M.vanbaalenii_PYR-1 HLGGFAKADDVLDFLHQHLLSG---HRP--
TH_2940|M.thermoresistible__bu HLGGFAAADEVLTFVRESL-----------
MAV_1342|M.avium_104 HLGGLGRGEEILSTLTKIWDEQN-------
MSMEG_3508|M.smegmatis_MC2_155 HLGGLGCAQEIMGTMLQIWDETSALT----
MAB_3556|M.abscessus_ATCC_1997 HFPQREDPLWVSGALLQWFKEWGNAR----
*: :