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MISNPWRHPPGVPRCEAPRAEGTFFLPDGRRLGYAEFGDPTGDVVLWFHGTPGGRRQLPIVGRRAAERLG LRVVLVERAGAGLSSAHRYDRIGDWADDMAHVADALGADKLGVAGLSGGGPYALACAGMPALRDRVAAVA VLGGVTPSVGPDATASGAITLARQLSAVTSALRRPFAAVTAGLLTPVIPLAHLAYSGLAAVMPDGDKRVF ANPEIEAMFIDDIVQVANGRFQALLDDARLFGVDWGFRLADVAVPVRWWHGDADSIISLADAQAAAEHLP DVDLLLMPDESHLGGFAKADDVLAFLAPHLRHDDEQHRRKV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0111 | - | - | 100% (321) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_3278 | - | 3e-67 | 42.51% (287) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_3121 | - | 3e-06 | 32.84% (134) | transcriptional regulator, CadC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1223 | - | 7e-66 | 42.56% (289) | hypothetical protein Mb1223 |
| M. tuberculosis H37Rv | Rv1191 | - | 7e-66 | 42.56% (289) | hypothetical protein Rv1191 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3390 | - | 1e-114 | 63.11% (309) | hydrolase |
| M. avium 104 | MAV_1342 | - | 7e-68 | 42.21% (289) | hydrolase, alpha/beta hydrolase fold family protein |
| M. smegmatis MC2 155 | MSMEG_3508 | - | 5e-71 | 45.49% (288) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_2940 | - | 1e-110 | 62.21% (299) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_2678 | - | 6e-22 | 30.60% (268) | hypothetical protein MUL_2678 |
| M. vanbaalenii PYR-1 | Mvan_0797 | - | 1e-159 | 86.45% (310) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1223|M.bovis_AF2122/97 -----------MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLH
Rv1191|M.tuberculosis_H37Rv -----------MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLH
MAV_1342|M.avium_104 -----------MAIEIARPKLEGNVAVGEDRQIGFAEFGDPQGRAMFWLH
MSMEG_3508|M.smegmatis_MC2_155 ---------MAMVIPIDRPKLEGNVAVGDDRRLGFAEFGDPQGRAIFWLH
Mflv_0111|M.gilvum_PYR-GCK -MISNPWRHPPGVPRCEAPRAEGTFFLPDGRRLGYAEFGDPTGDVVLWFH
Mvan_0797|M.vanbaalenii_PYR-1 -MLSNPWRHPPGVPRCEPPRAEGAFFLPDGRRIGYAEYGDPSGPVVLWFH
MMAR_3390|M.marinum_M MKLSNPLRHPFFVPRVEKPRAEGRFYLPDGRRLGFAEFGDPAGAVVLWFH
TH_2940|M.thermoresistible__bu ------------VPPTEKPRAEGRVHLPTGRRLGFAEFGDPAGVPVVWLH
MUL_2678|M.ulcerans_Agy99 ---------MQTLPEDIRADEANVVTLPDGRELACLEWGDPTGYPTFYFH
. . . : .*.:. *:* * * .::*
Mb1223|M.bovis_AF2122/97 GTPGARRQIPTEARVYAEHHNIRLIGVDRPGIGASTPHQYETILAFADDL
Rv1191|M.tuberculosis_H37Rv GTPGARRQIPTEARVYAEHHNIRLIGVDRPGIGASTPHQYETILAFADDL
MAV_1342|M.avium_104 GTPGARRQIPVEARLYAENHKIRLIGLDRPGIGSSTPHRYQNIRAFGEDL
MSMEG_3508|M.smegmatis_MC2_155 GTPGARRQIPTEARAYAEQNGVRLIGVDRPGIGSSTPHQYECVLDFASDL
Mflv_0111|M.gilvum_PYR-GCK GTPGGRRQLPIVGRRAAERLGLRVVLVERAGAGLSSAHRYDRIGDWADDM
Mvan_0797|M.vanbaalenii_PYR-1 GTPGGRRQLPIVGRRAAEKLGLRVVLVERAGSGLSHRHCYDRVGDWATDM
MMAR_3390|M.marinum_M GTPGARRQFPLLGRRAAEEFGLRVVVVERPGSGLSDCHAYTAMADWATDM
TH_2940|M.thermoresistible__bu GTPGGRRQFPLTGRRAAEQLGLRVVLLERPGAGLSDPYRYRSVADWVTDV
MUL_2678|M.ulcerans_Agy99 GTLSSRLEG-AFADGAARRARFRLIAVDRPGYGRSTFQEGRTLRDWPADV
** ..* : . *.. .*:: ::*.* * * : : *:
Mb1223|M.bovis_AF2122/97 RTIADTLGIDKMAVVGLSGGGPYTLACAAG--LPDRVVAAGVLGGVAPTR
Rv1191|M.tuberculosis_H37Rv RTIADTLGIDKMAVVGLSGGGPYTLACAAG--LPDRVVAAGVLGGVAPTR
MAV_1342|M.avium_104 RTIADTLGIDKMAVIGLSGGGPYALASAAV--LPDRVVAAGILGGVAPFL
MSMEG_3508|M.smegmatis_MC2_155 RTIADTLGIDKLAVIGLSGGGPYTLACAAA--MPDRVVAAGVLGGVAPMV
Mflv_0111|M.gilvum_PYR-GCK AHVADALGADKLGVAGLSGGGPYALACAGMPALRDRVAAVAVLGGVTPSV
Mvan_0797|M.vanbaalenii_PYR-1 AHVADLLGAEKLGVVGLSGGGPFALACAGMPALADRVVAVAVLGGVTPSV
MMAR_3390|M.marinum_M TAVANALGAERLAVVGLSGGGPYALACGAVAPLASRVATVAVLGGIVPSV
TH_2940|M.thermoresistible__bu TYVADAIGAERLAVVGLSGGGPYALACGAVAPLAERVRSIAVLGGVTPSV
MUL_2678|M.ulcerans_Agy99 CALADALGLDKFGVVGHSGAGTHLFACGAR-IALSRLAFIGALGPWGPLA
:*: :* :::.* * **.*.. :*... .*: . ** *
Mb1223|M.bovis_AF2122/97 GPDAISGGLMRLGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYG
Rv1191|M.tuberculosis_H37Rv GPDAISGGLMRLGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYG
MAV_1342|M.avium_104 GDEGITSGLMNLGKRVAPLLKLGGDPLRIGASLVVRAIRPVANPALYLYA
MSMEG_3508|M.smegmatis_MC2_155 GPDAISSPLMQLGAVVAPVLQVAGGPIRLVASGMIRLIRPVASPALEIYA
Mflv_0111|M.gilvum_PYR-GCK GPDATASGAITLARQLSAVTSALRRPFAAVTAGLLTPVIPLAHLAYSGLA
Mvan_0797|M.vanbaalenii_PYR-1 GPDAACSGAITLSRKFAPVTSAMRRPFAAVTAGLLTPVIPLAHLAYRGLS
MMAR_3390|M.marinum_M GPDATADAVTDLARRFTPILSELRRPLAALAAGLL-PLVPVSHYLYRAYA
TH_2940|M.thermoresistible__bu GPDASATGAIELARRFTSLLGTLRGPLATTLAGLVTPVLPFAHFACQAYA
MUL_2678|M.ulcerans_Agy99 TPEIMGS-LNLADRSYARLAQHGPRLFHALFAPLGWCAKYAPGLFTKLIT
: : : : : : .
Mb1223|M.bovis_AF2122/97 LLSPRADRHLLARPEFKAMFLDDLLNGSRKQLAAPFADVIAFARDWGFRL
Rv1191|M.tuberculosis_H37Rv LLSPRADRHLLARPEFKAMFLDDLLNGSRKQLAAPFADVIAFARDWGFRL
MAV_1342|M.avium_104 AISPEGDRRLLTRPEFGAMFLDDLLNGSRKQLAAPFNDIILFTQDWGFRL
MSMEG_3508|M.smegmatis_MC2_155 RLSPEGDRRMLGRPEFKAMFLDDLLNGSRKQLAAPFYDIVVFERDWGFRL
Mflv_0111|M.gilvum_PYR-GCK AVMPDGDKRVFANPEIEAMFIDDIVQVANGRFQALLDDARLFGVDWGFRL
Mvan_0797|M.vanbaalenii_PYR-1 AAMPEGDKRVFANPEIEAMFIDDIVHAANGGFQALLDDARLFGRDWGFRL
MMAR_3390|M.marinum_M SITPEGDQQVFADPELEAVFLDDIVLVVKSRCQAMIDDLRLFGRDWGFRL
TH_2940|M.thermoresistible__bu SISPESDRRVLHDPEMEAMFIDDLVLAARGGLRAIVDDARLFGRDWGFRL
MUL_2678|M.ulcerans_Agy99 ASVPAVDKHRMRDKRFVQHFQAVQLEAFRQGSRGAAYEAFLEYRPWEFDP
* *:: : .: * : . . : * *
Mb1223|M.bovis_AF2122/97 DEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESHLAGLGRG
Rv1191|M.tuberculosis_H37Rv DEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESHLAGLGRG
MAV_1342|M.avium_104 DQVKVPVRWWHGDSDHIVPFAHGQHVVSLLPDAELFVLPGESHLGGLGRG
MSMEG_3508|M.smegmatis_MC2_155 DEVTVPVRWWHGDHDHIVPFAHGQHVVSRLQDAKLTELPYESHLGGLGCA
Mflv_0111|M.gilvum_PYR-GCK ADVAVPVRWWHGDADSIISLADAQAAAEHLPDVDLLLMPDESHLGGFAKA
Mvan_0797|M.vanbaalenii_PYR-1 ADVKVPVRWWHGDADSIISLADAQAATEHLPDVELLLMPDESHLGGFAKA
MMAR_3390|M.marinum_M PDVTVPVRWWHGDADPLVPLAAARAAIARLPNAELIARPGESHLGGFAAA
TH_2940|M.thermoresistible__bu ADVRAPVRWWHGDSDHIVTLTDAQKAVERLPDAELVLRLEESHLGGFAAA
MUL_2678|M.ulcerans_Agy99 SEVDVPTHIWLGTHDSFVPREMGEYLERVIPNVELHWAAGKGHFN-VEDW
:* .*.: * * * ::. .. : :..* :.*: .
Mb1223|M.bovis_AF2122/97 EEILSTLMQIWDRDLRK-----
Rv1191|M.tuberculosis_H37Rv EEILSTLMQIWDRDLRK-----
MAV_1342|M.avium_104 EEILSTLTKIWDEQN-------
MSMEG_3508|M.smegmatis_MC2_155 QEIMGTMLQIWDETSALT----
Mflv_0111|M.gilvum_PYR-GCK DDVLAFLAPHLRHDDEQHRRKV
Mvan_0797|M.vanbaalenii_PYR-1 DDVLDFLHQHLLSG---HRP--
MMAR_3390|M.marinum_M DEVLQFVRSSL-----------
TH_2940|M.thermoresistible__bu DEVLTFVRESL-----------
MUL_2678|M.ulcerans_Agy99 DAIFAACAADI-----------
: ::