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VLEACQAIGVTAALGEPGEHSLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALV ARLGELLTAHQQDLATLVTVEVGKITAEARGEVQEMIDVCQFSVGLSRQLYGRTIASERAGHRLLETWHP LGVVGVITAFNFPVAVWAWNTAVALVCGDTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGG AERGAQLVDDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLELAVRGIVFAAAG TAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDPSAPDTLVGPLIHEAAYRDMVAALERARTDGGE VIGGDRREVGSPGAYYVAPAVVRMPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLSSSIFTTD LREAEHFLDQSDCGIANVNIGTSGAEIGGAFGGEKQTGGGRESGSDAWKAYMRRATNTVNYSSELPLAQG VKFG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv3293 | pcd | - | 100% (494) | PROBABLE PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE PCD (PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE) |
M. tuberculosis H37Rv | Rv0223c | - | 6e-54 | 32.15% (451) | aldehyde dehydrogenase |
M. tuberculosis H37Rv | Rv2858c | aldC | 5e-51 | 33.79% (441) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3321 | pcd | 0.0 | 99.80% (494) | piperideine-6-carboxilic acid dehydrogenase |
M. gilvum PYR-GCK | Mflv_4799 | - | 0.0 | 76.21% (496) | aldehyde dehydrogenase |
M. leprae Br4923 | MLBr_02573 | gabD1 | 5e-51 | 31.08% (444) | succinic semialdehyde dehydrogenase |
M. abscessus ATCC 19977 | MAB_3649 | - | 0.0 | 75.37% (479) | aldehyde dehydrogenase |
M. marinum M | MMAR_1240 | pcd | 0.0 | 81.38% (494) | piperideine-6-carboxilic acid dehydrogenase Pcd |
M. avium 104 | MAV_4265 | - | 0.0 | 80.00% (495) | aldehyde dehydrogenase (NAD) family protein |
M. smegmatis MC2 155 | MSMEG_1762 | - | 0.0 | 80.40% (500) | piperideine-6-carboxylic acid dehydrogenase |
M. thermoresistible (build 8) | TH_4531 | - | 1e-59 | 32.61% (463) | PUTATIVE putative betaine aldehyde dehydrogenase |
M. ulcerans Agy99 | MUL_2647 | pcd | 0.0 | 80.97% (494) | piperideine-6-carboxilic acid dehydrogenase Pcd |
M. vanbaalenii PYR-1 | Mvan_1643 | - | 0.0 | 77.42% (496) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4799|M.gilvum_PYR-GCK MSTAVT----------ALPTAEKLRTRVRDALAAVGARIALGVP---TAH Mvan_1643|M.vanbaalenii_PYR-1 MTTVVTP---------VLPTADALRTRVRDALAAVGATVPLGAP---GSE MAB_3649|M.abscessus_ATCC_1997 MTTTLPAPSP-----GVLPSADELRTRAQNALRWIGADVELNTEPPVGDQ MSMEG_1762|M.smegmatis_MC2_155 MTANITTDKPQGAGAAGLPTADELRQRVRRALDAIGATTALAEPGGASDG Rv3293|M.tuberculosis_H37Rv ---------------------------MLEACQAIGVTAALGEP---GEH Mb3321|M.bovis_AF2122/97 ---------------------------MLEACQAIGVTAALGEP---GEH MMAR_1240|M.marinum_M -----------------MTHSDELRNRVRKAFEAIGVTASLDEP---GGH MUL_2647|M.ulcerans_Agy99 -----------------MTHSDELRNRVRKAFEAIGVTASLDEP---GGH MAV_4265|M.avium_104 ---------------MTLPTADELRARAADALRSLGAHVELGAP---DAH TH_4531|M.thermoresistible__bu --------------------VTTTENRLVSEIHLAGRRLAEGSAG----- MLBr_02573|M.leprae_Br4923 -------------------------------------------------M Mflv_4799|M.gilvum_PYR-GCK GLPASTPITGDVLFTVPASSAADVDAAVGEAADAFSTWRTTPAPVRGTLV Mvan_1643|M.vanbaalenii_PYR-1 GLPASTPITGDVLFSVPQASAADADAAVAAAAEAFSTWRTTPAPVRGALV MAB_3649|M.abscessus_ATCC_1997 GVTVRTPITGDTLFILTASSKDDVDTAIAEAAQAFSQWRTTPGPIRGALV MSMEG_1762|M.smegmatis_MC2_155 DLHASTPITGDVLFTLPAHTAEAADAAIAEAAQAFSVWRTTPAPVRGALV Rv3293|M.tuberculosis_H37Rv SLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALV Mb3321|M.bovis_AF2122/97 SLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALV MMAR_1240|M.marinum_M GMPSSTPITCKTLFTLTATTAEQTERSIADAQAAFTQWRSTPAPVRGALV MUL_2647|M.ulcerans_Agy99 GMPSSTPITCETLFTLTATTAEQTERSIADAQAAFTQWRSTPAPVRGALV MAV_4265|M.avium_104 GLPASTPITGEVLFTVAPTTPDQAEHAITQAAQAFSEWRRTPAPVRGALV TH_4531|M.thermoresistible__bu VYEHVNPATGKVQGEVPLAGPAEVDEAVAAAQEAFKEWRKWRPEDRRRLL MLBr_02573|M.leprae_Br4923 SIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWA .* * .. .. .: :: * * :* * Mflv_4799|M.gilvum_PYR-GCK ARLGQLLVEHKSALASLVTIEAGKITSEALG-EVQEMIDICEFAVGLSRQ Mvan_1643|M.vanbaalenii_PYR-1 ARLGQLLVEHKTALATLVTIEAGKINSEALG-EVQEMIDICEFAVGLSRQ MAB_3649|M.abscessus_ATCC_1997 ARLGELLVEHKKDLAELVTIEAGKIVSEALG-EVQEMIDICQFAVGLSRQ MSMEG_1762|M.smegmatis_MC2_155 ARLGQLLVEHKADLATLVTVEAGKITSEALG-EVQEMIDICDFAVGLSRQ Rv3293|M.tuberculosis_H37Rv ARLGELLTAHQQDLATLVTVEVGKITAEARG-EVQEMIDVCQFSVGLSRQ Mb3321|M.bovis_AF2122/97 ARLGELLTAHQQDLATLVTVEVGKITAEARG-EVQEMIDVCQFSVGLSRQ MMAR_1240|M.marinum_M ARLGELISAHKHDLAELVTIEVGKTGSEALG-EVQEMIDICEFAVGLSRQ MUL_2647|M.ulcerans_Agy99 ARLGELISAHKHDLAELVTIEVGKTGSEALG-EVQEMIDICEFAVGLSRQ MAV_4265|M.avium_104 ARLGELLRAHRDELAALVTLEVGKITSEAAG-EVQEMIDICQFAVGLSRQ TH_4531|M.thermoresistible__bu TRIAERIRAHEDELAVLQARENGLPVSQGKAVLVPHGAGWFEAAAGWADK MLBr_02573|M.leprae_Br4923 NATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETL .: : . * * : * * .. : . : Mflv_4799|M.gilvum_PYR-GCK LYGRTIASERP-GHRLMENWHPLGVVGVITAFNFPVAVWAWNTAVALVCG Mvan_1643|M.vanbaalenii_PYR-1 LYGRTIASERP-GHRLMENWHPLGVVGVITAFNFPVAVWAWNTAIALVCG MAB_3649|M.abscessus_ATCC_1997 LYGKTMASERA-GHRLMESWHPLGVVGVISAFNFPVAVWSWNTAIALVCG MSMEG_1762|M.smegmatis_MC2_155 LYGRTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWSWNTAIALVCG Rv3293|M.tuberculosis_H37Rv LYGRTIASERA-GHRLLETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG Mb3321|M.bovis_AF2122/97 LYGRTIASERA-GHRLLETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG MMAR_1240|M.marinum_M LYGLTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG MUL_2647|M.ulcerans_Agy99 LYGLTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG MAV_4265|M.avium_104 LYGRTIASERP-GHRLSETWHPLGVVGVITAFNFPVAVWAWNAALALVCG TH_4531|M.thermoresistible__bu LEGAVVPTTPG-ETVDLTLLEPIGVVAVILTWNAPIGGWGMCVAPPLAAG MLBr_02573|M.leprae_Br4923 LADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAG * . : .*:*** .: .:* *: .* .* .* Mflv_4799|M.gilvum_PYR-GCK NTVVWKPSELTPLTAVACQALLERACADVGAPPAVGRLVLGEREVGEKLV Mvan_1643|M.vanbaalenii_PYR-1 DTVVWKPSELTPLTAVACQALLERACADVGAPAAVGRLVLGEREVGEKLV MAB_3649|M.abscessus_ATCC_1997 DTVVWKPSELTPLTAVACQALLDRAAADVGAPPQVSRLIQGGREVGEQLV MSMEG_1762|M.smegmatis_MC2_155 DTVVWKPSELTPLTAIACQALIERAAADVGAPAAVSRLVQGGREVGERLV Rv3293|M.tuberculosis_H37Rv DTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLV Mb3321|M.bovis_AF2122/97 DTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLV MMAR_1240|M.marinum_M DTVLWKPSELAPLTALACQALLTRAAADVGAPPSVGAVVLGGAELGEQLV MUL_2647|M.ulcerans_Agy99 DTVLWKPSELAPLTALACQALLTRAAADVGAPPSVGAVVLGGAELGEQLV MAV_4265|M.avium_104 DTVVWKPSELTPLTALATQALIARAAADVGAPPGVSAVVLGDRELGELLV TH_4531|M.thermoresistible__bu CCVILKPSELAPFTS----SFIARICEEEGMPPGVVTVLPGGPDAGEALV MLBr_02573|M.leprae_Br4923 NVGLLKHASNVPQCALYLADVIARG----GFPEDCFQTLLISANGVEAIL : * :. .* : .: * * * : : :: Mflv_4799|M.gilvum_PYR-GCK DDPRVSLVSATGSVRMGREVGPRVAARFGRVLLELGGNNAAVVTPAADLD Mvan_1643|M.vanbaalenii_PYR-1 DDPRVALVSATGSVRMGREVGPRVAARFGRALLELGGNNAAIVTPAADLD MAB_3649|M.abscessus_ATCC_1997 DDPRIALVSATGSVRMGQQVGPRVAARFGRSLLELGGNNAAIVTPSADLD MSMEG_1762|M.smegmatis_MC2_155 DDPRVALVSATGSVRMGREVGPRVAARFGKVLLELGGNNAAIVTPSADLD Rv3293|M.tuberculosis_H37Rv DDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLE Mb3321|M.bovis_AF2122/97 DDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLE MMAR_1240|M.marinum_M DDPRIALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAVIVTPSADLD MUL_2647|M.ulcerans_Agy99 DDPRIALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAVIVTPSADLD MAV_4265|M.avium_104 DDERVALVSATGSVRMGRAVGPRVAARFGRVLLELGGNNAAVVTPSADLD TH_4531|M.thermoresistible__bu RHPGVAKVSFTGGGPTGRKIAAACGEQLKPVLLELGGKSANIVFPDADLA MLBr_02573|M.leprae_Br4923 RDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLD . :: : **. *: :.. . .: :*****... :* * *** Mflv_4799|M.gilvum_PYR-GCK LAVRGIVFSAAGTAGQRCTTLRRLIVHSSIADELVSRIVKANEQLPVGDP Mvan_1643|M.vanbaalenii_PYR-1 LAVRGIVFSAAGTAGQRCTTLRRLIVHSSVADELVSRIVAAYKQLPVGDP MAB_3649|M.abscessus_ATCC_1997 LAVRGIVFSAAGTAGQRCTTLRRLIVHRSIADGLVERIVHAYGQLPVGSP MSMEG_1762|M.smegmatis_MC2_155 LAVRAIVFSAAGTAGQRCTTLRRLIVHSSVADEVVRRVVSAYQSLPIGDP Rv3293|M.tuberculosis_H37Rv LAVRGIVFAAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDP Mb3321|M.bovis_AF2122/97 LAVRCIVFAAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDP MMAR_1240|M.marinum_M LAVRGIVFAAAGTAGQRCTSLRRLIVHSSVADDVVARVVAACRTLPVGDP MUL_2647|M.ulcerans_Agy99 LAVRGIVFAAAGTAGQRCTSLRRLIVHSSVADDVVARVVAACRTLPVGDP MAV_4265|M.avium_104 LAVRAVVFAAAGTAGQRCTTLRRLIVHHSVADEVVARVVSALRRLPIGDP TH_4531|M.thermoresistible__bu KAA-ETAASVIFSAGQACTLPTRILVHESIYDEFTAMVAGALGQIPLGDP MLBr_02573|M.leprae_Br4923 AAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDP *. . . . ** * *::.* .: * .. .. : :*.* Mflv_4799|M.gilvum_PYR-GCK FRGGTLVGPLIHTRAYRDMVGALQQAQAE-GGEVIGGERVD--VGDE-GA Mvan_1643|M.vanbaalenii_PYR-1 FADRTLVGPLIHTASYRDMVLALQQATAE-GGTVLGGERVD--VGDE-GA MAB_3649|M.abscessus_ATCC_1997 FDEQTLIGPLINDKAFRDMQDALETARAQ-GGTVVGGERRE--LGD--GS MSMEG_1762|M.smegmatis_MC2_155 SAEGTLVGPLIHARAYRDMVGALEQARAD-GGTVHGGERHE--LGDEEGA Rv3293|M.tuberculosis_H37Rv SAPDTLVGPLIHEAAYRDMVAALERARTD-GGEVIGGDRRE---VGSPGA Mb3321|M.bovis_AF2122/97 SAPDTLVGPLIHEAAYRDMVAALERARTD-GGEVIGGDRRE---VGSPGA MMAR_1240|M.marinum_M CDPATLIGPLIHETAYRDMLGALDQARAE-GGEVIDPNPRR---DGPAGG MUL_2647|M.ulcerans_Agy99 CDPATLIGPLIHETAYRDMLGALDQARAE-GGEVIDPNPRR---DGPAGG MAV_4265|M.avium_104 FEPGTLVGPLIHETAYRDMVGALESARAD-GGEVIDGDRRHPFAVEHPSS TH_4531|M.thermoresistible__bu LDPATMMGPVISEAAVERILRTVDEATRDNGAELLTGGSRAG--GELASG MLBr_02573|M.leprae_Br4923 TDPDTDVGPLATESGRAQVEQQVDAAAAA-GAVIRCGGKRP-----DRPG * :**: . : :: * *. : . Mflv_4799|M.gilvum_PYR-GCK FYVTPAVVR-MPEQSAVVHQETFAPILYVLTYDTLDEAIALNNAVPQGLS Mvan_1643|M.vanbaalenii_PYR-1 FYVTPAVVR-MPAQSAVVHKETFAPILYVMTYETLDEAIALNNAVPQGLS MAB_3649|M.abscessus_ATCC_1997 FYVTPAVVR-MPEQSDVVHRETFAPILYVLDYDTLDEAIALNNAVPQGLS MSMEG_1762|M.smegmatis_MC2_155 FYVAPAVVV-MPAQTEIVHNETFAPILYVLTYDDLDEAIALNNAVPQGLS Rv3293|M.tuberculosis_H37Rv YYVAPAVVR-MPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLS Mb3321|M.bovis_AF2122/97 YYVAPAVVR-MPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLS MMAR_1240|M.marinum_M YYVAPAVVR-MPAQTAIVATETFAPILYVLTYDDLDDAIALNNAVPQGLS MUL_2647|M.ulcerans_Agy99 YYVAPAVVR-MPAQTAIVATETFAPILYVLTYDDLDDAIALNNAVPQGLS MAV_4265|M.avium_104 YYVAPAVVR-MPAQTPIVATETFAPILYVLTYDRLDDAIALNNAVPQGLS TH_4531|M.thermoresistible__bu YYIEPTLLGNVSPTSEVAQNEVFGPVTAAIRFSDEEEAVAIANGTPYGLA MLBr_02573|M.leprae_Br4923 WFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLG :: *::: :. : *.*.*: . ::*: : *..* **. Mflv_4799|M.gilvum_PYR-GCK SSIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR Mvan_1643|M.vanbaalenii_PYR-1 SSIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR MAB_3649|M.abscessus_ATCC_1997 SAIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR MSMEG_1762|M.smegmatis_MC2_155 SAIFTTDVREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKQTGGGR Rv3293|M.tuberculosis_H37Rv SSIFTTDLREAEHFLDQ--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR Mb3321|M.bovis_AF2122/97 SSIFTTDLREAEHFLDQ--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR MMAR_1240|M.marinum_M SAIFTNDLREAERFLAA--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR MUL_2647|M.ulcerans_Agy99 SAFFTNDLREAERFLAA--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR MAV_4265|M.avium_104 SAIFTTDLREAERFLDE--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR TH_4531|M.thermoresistible__bu GYVHTRDVSRVLRLASA--LEAGTVAFNGAGAPAGPGAPFGGYKESGYGR MLBr_02573|M.leprae_Br4923 SNAWTQNESEQRHFIDN--IVAGQVFING-MTVSYPELPFGGIKRSGYGR . * : . :: .* . .* : : .*** *.:* ** Mflv_4799|M.gilvum_PYR-GCK ESGSDSWKAYMRRATNTVNYSSDLPLAQGVEFG Mvan_1643|M.vanbaalenii_PYR-1 ESGSDSWKAYMRRATNTVNYSTELPLAQGVHFG MAB_3649|M.abscessus_ATCC_1997 ESGSDSWKAYMRRVTNTVNYSTELPLAQGVHFG MSMEG_1762|M.smegmatis_MC2_155 ESGSDAWKAYMRRATNTVNYSSELPLAQGVHFG Rv3293|M.tuberculosis_H37Rv ESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG Mb3321|M.bovis_AF2122/97 ESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG MMAR_1240|M.marinum_M ESGSDAWKAYMRRATNTINYSTELPLAQGVQFG MUL_2647|M.ulcerans_Agy99 ESGSDAWKAYMRRATNTINYSTELPLAQSVQFG MAV_4265|M.avium_104 ESGSDSWKAYMRQSTNTVNYSGALPLAQGVEFG TH_4531|M.thermoresistible__bu EGGKLGVLEFVQHKTVSVALS------------ MLBr_02573|M.leprae_Br4923 ELSTHGIREFCNIKTVWIA-------------- * .. . : . * :