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M. tuberculosis H37Rv Rv3293 (pcd)

annotation: PROBABLE PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE PCD (PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE)
coordinates: 3673602 - 3675086
length: 494

VLEACQAIGVTAALGEPGEHSLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALV
ARLGELLTAHQQDLATLVTVEVGKITAEARGEVQEMIDVCQFSVGLSRQLYGRTIASERAGHRLLETWHP
LGVVGVITAFNFPVAVWAWNTAVALVCGDTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGG
AERGAQLVDDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLELAVRGIVFAAAG
TAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDPSAPDTLVGPLIHEAAYRDMVAALERARTDGGE
VIGGDRREVGSPGAYYVAPAVVRMPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLSSSIFTTD
LREAEHFLDQSDCGIANVNIGTSGAEIGGAFGGEKQTGGGRESGSDAWKAYMRRATNTVNYSSELPLAQG
VKFG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv3293pcd-100% (494)PROBABLE PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE PCD (PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE)
M. tuberculosis H37RvRv0223c-6e-5432.15% (451) aldehyde dehydrogenase
M. tuberculosis H37RvRv2858caldC5e-5133.79% (441) aldehyde dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3321pcd0.099.80% (494) piperideine-6-carboxilic acid dehydrogenase
M. gilvum PYR-GCKMflv_4799-0.076.21% (496) aldehyde dehydrogenase
M. leprae Br4923MLBr_02573gabD15e-5131.08% (444) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_3649-0.075.37% (479) aldehyde dehydrogenase
M. marinum MMMAR_1240pcd0.081.38% (494) piperideine-6-carboxilic acid dehydrogenase Pcd
M. avium 104MAV_4265-0.080.00% (495) aldehyde dehydrogenase (NAD) family protein
M. smegmatis MC2 155MSMEG_1762-0.080.40% (500) piperideine-6-carboxylic acid dehydrogenase
M. thermoresistible (build 8)TH_4531-1e-5932.61% (463) PUTATIVE putative betaine aldehyde dehydrogenase
M. ulcerans Agy99MUL_2647pcd0.080.97% (494) piperideine-6-carboxilic acid dehydrogenase Pcd
M. vanbaalenii PYR-1Mvan_1643-0.077.42% (496) aldehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4799|M.gilvum_PYR-GCK          MSTAVT----------ALPTAEKLRTRVRDALAAVGARIALGVP---TAH
Mvan_1643|M.vanbaalenii_PYR-1       MTTVVTP---------VLPTADALRTRVRDALAAVGATVPLGAP---GSE
MAB_3649|M.abscessus_ATCC_1997      MTTTLPAPSP-----GVLPSADELRTRAQNALRWIGADVELNTEPPVGDQ
MSMEG_1762|M.smegmatis_MC2_155      MTANITTDKPQGAGAAGLPTADELRQRVRRALDAIGATTALAEPGGASDG
Rv3293|M.tuberculosis_H37Rv         ---------------------------MLEACQAIGVTAALGEP---GEH
Mb3321|M.bovis_AF2122/97            ---------------------------MLEACQAIGVTAALGEP---GEH
MMAR_1240|M.marinum_M               -----------------MTHSDELRNRVRKAFEAIGVTASLDEP---GGH
MUL_2647|M.ulcerans_Agy99           -----------------MTHSDELRNRVRKAFEAIGVTASLDEP---GGH
MAV_4265|M.avium_104                ---------------MTLPTADELRARAADALRSLGAHVELGAP---DAH
TH_4531|M.thermoresistible__bu      --------------------VTTTENRLVSEIHLAGRRLAEGSAG-----
MLBr_02573|M.leprae_Br4923          -------------------------------------------------M
                                                                                      

Mflv_4799|M.gilvum_PYR-GCK          GLPASTPITGDVLFTVPASSAADVDAAVGEAADAFSTWRTTPAPVRGTLV
Mvan_1643|M.vanbaalenii_PYR-1       GLPASTPITGDVLFSVPQASAADADAAVAAAAEAFSTWRTTPAPVRGALV
MAB_3649|M.abscessus_ATCC_1997      GVTVRTPITGDTLFILTASSKDDVDTAIAEAAQAFSQWRTTPGPIRGALV
MSMEG_1762|M.smegmatis_MC2_155      DLHASTPITGDVLFTLPAHTAEAADAAIAEAAQAFSVWRTTPAPVRGALV
Rv3293|M.tuberculosis_H37Rv         SLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALV
Mb3321|M.bovis_AF2122/97            SLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALV
MMAR_1240|M.marinum_M               GMPSSTPITCKTLFTLTATTAEQTERSIADAQAAFTQWRSTPAPVRGALV
MUL_2647|M.ulcerans_Agy99           GMPSSTPITCETLFTLTATTAEQTERSIADAQAAFTQWRSTPAPVRGALV
MAV_4265|M.avium_104                GLPASTPITGEVLFTVAPTTPDQAEHAITQAAQAFSEWRRTPAPVRGALV
TH_4531|M.thermoresistible__bu      VYEHVNPATGKVQGEVPLAGPAEVDEAVAAAQEAFKEWRKWRPEDRRRLL
MLBr_02573|M.leprae_Br4923          SIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWA
                                         .* * ..   ..      .: ::  *   *  :*      *    

Mflv_4799|M.gilvum_PYR-GCK          ARLGQLLVEHKSALASLVTIEAGKITSEALG-EVQEMIDICEFAVGLSRQ
Mvan_1643|M.vanbaalenii_PYR-1       ARLGQLLVEHKTALATLVTIEAGKINSEALG-EVQEMIDICEFAVGLSRQ
MAB_3649|M.abscessus_ATCC_1997      ARLGELLVEHKKDLAELVTIEAGKIVSEALG-EVQEMIDICQFAVGLSRQ
MSMEG_1762|M.smegmatis_MC2_155      ARLGQLLVEHKADLATLVTVEAGKITSEALG-EVQEMIDICDFAVGLSRQ
Rv3293|M.tuberculosis_H37Rv         ARLGELLTAHQQDLATLVTVEVGKITAEARG-EVQEMIDVCQFSVGLSRQ
Mb3321|M.bovis_AF2122/97            ARLGELLTAHQQDLATLVTVEVGKITAEARG-EVQEMIDVCQFSVGLSRQ
MMAR_1240|M.marinum_M               ARLGELISAHKHDLAELVTIEVGKTGSEALG-EVQEMIDICEFAVGLSRQ
MUL_2647|M.ulcerans_Agy99           ARLGELISAHKHDLAELVTIEVGKTGSEALG-EVQEMIDICEFAVGLSRQ
MAV_4265|M.avium_104                ARLGELLRAHRDELAALVTLEVGKITSEAAG-EVQEMIDICQFAVGLSRQ
TH_4531|M.thermoresistible__bu      TRIAERIRAHEDELAVLQARENGLPVSQGKAVLVPHGAGWFEAAAGWADK
MLBr_02573|M.leprae_Br4923          NATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETL
                                       .: :  .    * * : * *    ..    :    .    :      

Mflv_4799|M.gilvum_PYR-GCK          LYGRTIASERP-GHRLMENWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
Mvan_1643|M.vanbaalenii_PYR-1       LYGRTIASERP-GHRLMENWHPLGVVGVITAFNFPVAVWAWNTAIALVCG
MAB_3649|M.abscessus_ATCC_1997      LYGKTMASERA-GHRLMESWHPLGVVGVISAFNFPVAVWSWNTAIALVCG
MSMEG_1762|M.smegmatis_MC2_155      LYGRTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWSWNTAIALVCG
Rv3293|M.tuberculosis_H37Rv         LYGRTIASERA-GHRLLETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
Mb3321|M.bovis_AF2122/97            LYGRTIASERA-GHRLLETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
MMAR_1240|M.marinum_M               LYGLTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
MUL_2647|M.ulcerans_Agy99           LYGLTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
MAV_4265|M.avium_104                LYGRTIASERP-GHRLSETWHPLGVVGVITAFNFPVAVWAWNAALALVCG
TH_4531|M.thermoresistible__bu      LEGAVVPTTPG-ETVDLTLLEPIGVVAVILTWNAPIGGWGMCVAPPLAAG
MLBr_02573|M.leprae_Br4923          LADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAG
                                    * .    :            .*:*** .: .:* *:      .* .* .*

Mflv_4799|M.gilvum_PYR-GCK          NTVVWKPSELTPLTAVACQALLERACADVGAPPAVGRLVLGEREVGEKLV
Mvan_1643|M.vanbaalenii_PYR-1       DTVVWKPSELTPLTAVACQALLERACADVGAPAAVGRLVLGEREVGEKLV
MAB_3649|M.abscessus_ATCC_1997      DTVVWKPSELTPLTAVACQALLDRAAADVGAPPQVSRLIQGGREVGEQLV
MSMEG_1762|M.smegmatis_MC2_155      DTVVWKPSELTPLTAIACQALIERAAADVGAPAAVSRLVQGGREVGERLV
Rv3293|M.tuberculosis_H37Rv         DTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLV
Mb3321|M.bovis_AF2122/97            DTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLV
MMAR_1240|M.marinum_M               DTVLWKPSELAPLTALACQALLTRAAADVGAPPSVGAVVLGGAELGEQLV
MUL_2647|M.ulcerans_Agy99           DTVLWKPSELAPLTALACQALLTRAAADVGAPPSVGAVVLGGAELGEQLV
MAV_4265|M.avium_104                DTVVWKPSELTPLTALATQALIARAAADVGAPPGVSAVVLGDRELGELLV
TH_4531|M.thermoresistible__bu      CCVILKPSELAPFTS----SFIARICEEEGMPPGVVTVLPGGPDAGEALV
MLBr_02573|M.leprae_Br4923          NVGLLKHASNVPQCALYLADVIARG----GFPEDCFQTLLISANGVEAIL
                                       : * :. .*  :     .: *     * *      :    :    ::

Mflv_4799|M.gilvum_PYR-GCK          DDPRVSLVSATGSVRMGREVGPRVAARFGRVLLELGGNNAAVVTPAADLD
Mvan_1643|M.vanbaalenii_PYR-1       DDPRVALVSATGSVRMGREVGPRVAARFGRALLELGGNNAAIVTPAADLD
MAB_3649|M.abscessus_ATCC_1997      DDPRIALVSATGSVRMGQQVGPRVAARFGRSLLELGGNNAAIVTPSADLD
MSMEG_1762|M.smegmatis_MC2_155      DDPRVALVSATGSVRMGREVGPRVAARFGKVLLELGGNNAAIVTPSADLD
Rv3293|M.tuberculosis_H37Rv         DDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLE
Mb3321|M.bovis_AF2122/97            DDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLE
MMAR_1240|M.marinum_M               DDPRIALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAVIVTPSADLD
MUL_2647|M.ulcerans_Agy99           DDPRIALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAVIVTPSADLD
MAV_4265|M.avium_104                DDERVALVSATGSVRMGRAVGPRVAARFGRVLLELGGNNAAVVTPSADLD
TH_4531|M.thermoresistible__bu      RHPGVAKVSFTGGGPTGRKIAAACGEQLKPVLLELGGKSANIVFPDADLA
MLBr_02573|M.leprae_Br4923          RDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLD
                                     .  ::  : **.   *: :..  . .:   :*****... :* * *** 

Mflv_4799|M.gilvum_PYR-GCK          LAVRGIVFSAAGTAGQRCTTLRRLIVHSSIADELVSRIVKANEQLPVGDP
Mvan_1643|M.vanbaalenii_PYR-1       LAVRGIVFSAAGTAGQRCTTLRRLIVHSSVADELVSRIVAAYKQLPVGDP
MAB_3649|M.abscessus_ATCC_1997      LAVRGIVFSAAGTAGQRCTTLRRLIVHRSIADGLVERIVHAYGQLPVGSP
MSMEG_1762|M.smegmatis_MC2_155      LAVRAIVFSAAGTAGQRCTTLRRLIVHSSVADEVVRRVVSAYQSLPIGDP
Rv3293|M.tuberculosis_H37Rv         LAVRGIVFAAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDP
Mb3321|M.bovis_AF2122/97            LAVRCIVFAAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDP
MMAR_1240|M.marinum_M               LAVRGIVFAAAGTAGQRCTSLRRLIVHSSVADDVVARVVAACRTLPVGDP
MUL_2647|M.ulcerans_Agy99           LAVRGIVFAAAGTAGQRCTSLRRLIVHSSVADDVVARVVAACRTLPVGDP
MAV_4265|M.avium_104                LAVRAVVFAAAGTAGQRCTTLRRLIVHHSVADEVVARVVSALRRLPIGDP
TH_4531|M.thermoresistible__bu      KAA-ETAASVIFSAGQACTLPTRILVHESIYDEFTAMVAGALGQIPLGDP
MLBr_02573|M.leprae_Br4923          AAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDP
                                     *.   . .   . ** *    *::.* .: * ..  ..     : :*.*

Mflv_4799|M.gilvum_PYR-GCK          FRGGTLVGPLIHTRAYRDMVGALQQAQAE-GGEVIGGERVD--VGDE-GA
Mvan_1643|M.vanbaalenii_PYR-1       FADRTLVGPLIHTASYRDMVLALQQATAE-GGTVLGGERVD--VGDE-GA
MAB_3649|M.abscessus_ATCC_1997      FDEQTLIGPLINDKAFRDMQDALETARAQ-GGTVVGGERRE--LGD--GS
MSMEG_1762|M.smegmatis_MC2_155      SAEGTLVGPLIHARAYRDMVGALEQARAD-GGTVHGGERHE--LGDEEGA
Rv3293|M.tuberculosis_H37Rv         SAPDTLVGPLIHEAAYRDMVAALERARTD-GGEVIGGDRRE---VGSPGA
Mb3321|M.bovis_AF2122/97            SAPDTLVGPLIHEAAYRDMVAALERARTD-GGEVIGGDRRE---VGSPGA
MMAR_1240|M.marinum_M               CDPATLIGPLIHETAYRDMLGALDQARAE-GGEVIDPNPRR---DGPAGG
MUL_2647|M.ulcerans_Agy99           CDPATLIGPLIHETAYRDMLGALDQARAE-GGEVIDPNPRR---DGPAGG
MAV_4265|M.avium_104                FEPGTLVGPLIHETAYRDMVGALESARAD-GGEVIDGDRRHPFAVEHPSS
TH_4531|M.thermoresistible__bu      LDPATMMGPVISEAAVERILRTVDEATRDNGAELLTGGSRAG--GELASG
MLBr_02573|M.leprae_Br4923          TDPDTDVGPLATESGRAQVEQQVDAAAAA-GAVIRCGGKRP-----DRPG
                                        * :**:    .   :   :: *    *. :               .

Mflv_4799|M.gilvum_PYR-GCK          FYVTPAVVR-MPEQSAVVHQETFAPILYVLTYDTLDEAIALNNAVPQGLS
Mvan_1643|M.vanbaalenii_PYR-1       FYVTPAVVR-MPAQSAVVHKETFAPILYVMTYETLDEAIALNNAVPQGLS
MAB_3649|M.abscessus_ATCC_1997      FYVTPAVVR-MPEQSDVVHRETFAPILYVLDYDTLDEAIALNNAVPQGLS
MSMEG_1762|M.smegmatis_MC2_155      FYVAPAVVV-MPAQTEIVHNETFAPILYVLTYDDLDEAIALNNAVPQGLS
Rv3293|M.tuberculosis_H37Rv         YYVAPAVVR-MPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLS
Mb3321|M.bovis_AF2122/97            YYVAPAVVR-MPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLS
MMAR_1240|M.marinum_M               YYVAPAVVR-MPAQTAIVATETFAPILYVLTYDDLDDAIALNNAVPQGLS
MUL_2647|M.ulcerans_Agy99           YYVAPAVVR-MPAQTAIVATETFAPILYVLTYDDLDDAIALNNAVPQGLS
MAV_4265|M.avium_104                YYVAPAVVR-MPAQTPIVATETFAPILYVLTYDRLDDAIALNNAVPQGLS
TH_4531|M.thermoresistible__bu      YYIEPTLLGNVSPTSEVAQNEVFGPVTAAIRFSDEEEAVAIANGTPYGLA
MLBr_02573|M.leprae_Br4923          WFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLG
                                    ::  *:::  :.    :   *.*.*:  .      ::*: : *..* **.

Mflv_4799|M.gilvum_PYR-GCK          SSIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR
Mvan_1643|M.vanbaalenii_PYR-1       SSIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR
MAB_3649|M.abscessus_ATCC_1997      SAIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR
MSMEG_1762|M.smegmatis_MC2_155      SAIFTTDVREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
Rv3293|M.tuberculosis_H37Rv         SSIFTTDLREAEHFLDQ--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
Mb3321|M.bovis_AF2122/97            SSIFTTDLREAEHFLDQ--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
MMAR_1240|M.marinum_M               SAIFTNDLREAERFLAA--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
MUL_2647|M.ulcerans_Agy99           SAFFTNDLREAERFLAA--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
MAV_4265|M.avium_104                SAIFTTDLREAERFLDE--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
TH_4531|M.thermoresistible__bu      GYVHTRDVSRVLRLASA--LEAGTVAFNGAGAPAGPGAPFGGYKESGYGR
MLBr_02573|M.leprae_Br4923          SNAWTQNESEQRHFIDN--IVAGQVFING-MTVSYPELPFGGIKRSGYGR
                                    .   * :  .  ::       .* . .*   : :    .*** *.:* **

Mflv_4799|M.gilvum_PYR-GCK          ESGSDSWKAYMRRATNTVNYSSDLPLAQGVEFG
Mvan_1643|M.vanbaalenii_PYR-1       ESGSDSWKAYMRRATNTVNYSTELPLAQGVHFG
MAB_3649|M.abscessus_ATCC_1997      ESGSDSWKAYMRRVTNTVNYSTELPLAQGVHFG
MSMEG_1762|M.smegmatis_MC2_155      ESGSDAWKAYMRRATNTVNYSSELPLAQGVHFG
Rv3293|M.tuberculosis_H37Rv         ESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG
Mb3321|M.bovis_AF2122/97            ESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG
MMAR_1240|M.marinum_M               ESGSDAWKAYMRRATNTINYSTELPLAQGVQFG
MUL_2647|M.ulcerans_Agy99           ESGSDAWKAYMRRATNTINYSTELPLAQSVQFG
MAV_4265|M.avium_104                ESGSDSWKAYMRQSTNTVNYSGALPLAQGVEFG
TH_4531|M.thermoresistible__bu      EGGKLGVLEFVQHKTVSVALS------------
MLBr_02573|M.leprae_Br4923          ELSTHGIREFCNIKTVWIA--------------
                                    * .. .   : .  *  :