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TTVVTPVLPTADALRTRVRDALAAVGATVPLGAPGSEGLPASTPITGDVLFSVPQASAADADAAVAAAAE AFSTWRTTPAPVRGALVARLGQLLVEHKTALATLVTIEAGKINSEALGEVQEMIDICEFAVGLSRQLYGR TIASERPGHRLMENWHPLGVVGVITAFNFPVAVWAWNTAIALVCGDTVVWKPSELTPLTAVACQALLERA CADVGAPAAVGRLVLGEREVGEKLVDDPRVALVSATGSVRMGREVGPRVAARFGRALLELGGNNAAIVTP AADLDLAVRGIVFSAAGTAGQRCTTLRRLIVHSSVADELVSRIVAAYKQLPVGDPFADRTLVGPLIHTAS YRDMVLALQQATAEGGTVLGGERVDVGDEGAFYVTPAVVRMPAQSAVVHKETFAPILYVMTYETLDEAIA LNNAVPQGLSSSIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGRESGSDSWKAY MRRATNTVNYSTELPLAQGVHFG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1643 | - | - | 100% (514) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1856 | - | 7e-70 | 36.04% (444) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1824 | - | 9e-55 | 32.31% (489) | methylmalonate-semialdehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3321 | pcd | 0.0 | 77.22% (496) | piperideine-6-carboxilic acid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4799 | - | 0.0 | 90.27% (514) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv3293 | pcd | 0.0 | 77.42% (496) | piperideine-6-carboxilic acid dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 7e-40 | 30.32% (442) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3649 | - | 0.0 | 79.58% (519) | aldehyde dehydrogenase |
| M. marinum M | MMAR_1240 | pcd | 0.0 | 75.35% (503) | piperideine-6-carboxilic acid dehydrogenase Pcd |
| M. avium 104 | MAV_4265 | - | 0.0 | 75.83% (509) | aldehyde dehydrogenase (NAD) family protein |
| M. smegmatis MC2 155 | MSMEG_1762 | - | 0.0 | 84.31% (510) | piperideine-6-carboxylic acid dehydrogenase |
| M. thermoresistible (build 8) | TH_4531 | - | 1e-58 | 33.47% (478) | PUTATIVE putative betaine aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2647 | pcd | 0.0 | 74.95% (503) | piperideine-6-carboxilic acid dehydrogenase Pcd |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1643|M.vanbaalenii_PYR-1 MTTVVTP---------VLPTADALRTRVRDALAAVGATVPLGAP---GSE
Mflv_4799|M.gilvum_PYR-GCK MSTAVT----------ALPTAEKLRTRVRDALAAVGARIALGVP---TAH
MAB_3649|M.abscessus_ATCC_1997 MTTTLPAPSP-----GVLPSADELRTRAQNALRWIGADVELNTEPPVGDQ
MSMEG_1762|M.smegmatis_MC2_155 MTANITTDKPQGAGAAGLPTADELRQRVRRALDAIGATTALAEPGGASDG
Mb3321|M.bovis_AF2122/97 ---------------------------MLEACQAIGVTAALGEP---GEH
Rv3293|M.tuberculosis_H37Rv ---------------------------MLEACQAIGVTAALGEP---GEH
MMAR_1240|M.marinum_M -----------------MTHSDELRNRVRKAFEAIGVTASLDEP---GGH
MUL_2647|M.ulcerans_Agy99 -----------------MTHSDELRNRVRKAFEAIGVTASLDEP---GGH
MAV_4265|M.avium_104 ---------------MTLPTADELRARAADALRSLGAHVELGAP---DAH
TH_4531|M.thermoresistible__bu --------------------VTTTENRLVSEIHLAGRRLAEGSAG-----
MLBr_02573|M.leprae_Br4923 -------------------------------------------------M
Mvan_1643|M.vanbaalenii_PYR-1 GLPASTPITGDVLFSVPQASAADADAAVAAAAEAFSTWRTTPAPVRGALV
Mflv_4799|M.gilvum_PYR-GCK GLPASTPITGDVLFTVPASSAADVDAAVGEAADAFSTWRTTPAPVRGTLV
MAB_3649|M.abscessus_ATCC_1997 GVTVRTPITGDTLFILTASSKDDVDTAIAEAAQAFSQWRTTPGPIRGALV
MSMEG_1762|M.smegmatis_MC2_155 DLHASTPITGDVLFTLPAHTAEAADAAIAEAAQAFSVWRTTPAPVRGALV
Mb3321|M.bovis_AF2122/97 SLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALV
Rv3293|M.tuberculosis_H37Rv SLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALV
MMAR_1240|M.marinum_M GMPSSTPITCKTLFTLTATTAEQTERSIADAQAAFTQWRSTPAPVRGALV
MUL_2647|M.ulcerans_Agy99 GMPSSTPITCETLFTLTATTAEQTERSIADAQAAFTQWRSTPAPVRGALV
MAV_4265|M.avium_104 GLPASTPITGEVLFTVAPTTPDQAEHAITQAAQAFSEWRRTPAPVRGALV
TH_4531|M.thermoresistible__bu VYEHVNPATGKVQGEVPLAGPAEVDEAVAAAQEAFKEWRKWRPEDRRRLL
MLBr_02573|M.leprae_Br4923 SIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWA
.* * .. .. .: :: * * :* *
Mvan_1643|M.vanbaalenii_PYR-1 ARLGQLLVEHKTALATLVTIEAGKINSEALG-EVQEMIDICEFAVGLSRQ
Mflv_4799|M.gilvum_PYR-GCK ARLGQLLVEHKSALASLVTIEAGKITSEALG-EVQEMIDICEFAVGLSRQ
MAB_3649|M.abscessus_ATCC_1997 ARLGELLVEHKKDLAELVTIEAGKIVSEALG-EVQEMIDICQFAVGLSRQ
MSMEG_1762|M.smegmatis_MC2_155 ARLGQLLVEHKADLATLVTVEAGKITSEALG-EVQEMIDICDFAVGLSRQ
Mb3321|M.bovis_AF2122/97 ARLGELLTAHQQDLATLVTVEVGKITAEARG-EVQEMIDVCQFSVGLSRQ
Rv3293|M.tuberculosis_H37Rv ARLGELLTAHQQDLATLVTVEVGKITAEARG-EVQEMIDVCQFSVGLSRQ
MMAR_1240|M.marinum_M ARLGELISAHKHDLAELVTIEVGKTGSEALG-EVQEMIDICEFAVGLSRQ
MUL_2647|M.ulcerans_Agy99 ARLGELISAHKHDLAELVTIEVGKTGSEALG-EVQEMIDICEFAVGLSRQ
MAV_4265|M.avium_104 ARLGELLRAHRDELAALVTLEVGKITSEAAG-EVQEMIDICQFAVGLSRQ
TH_4531|M.thermoresistible__bu TRIAERIRAHEDELAVLQARENGLPVSQGKAVLVPHGAGWFEAAAGWADK
MLBr_02573|M.leprae_Br4923 NATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETL
.: : . * * : * * .. : . :
Mvan_1643|M.vanbaalenii_PYR-1 LYGRTIASERP-GHRLMENWHPLGVVGVITAFNFPVAVWAWNTAIALVCG
Mflv_4799|M.gilvum_PYR-GCK LYGRTIASERP-GHRLMENWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
MAB_3649|M.abscessus_ATCC_1997 LYGKTMASERA-GHRLMESWHPLGVVGVISAFNFPVAVWSWNTAIALVCG
MSMEG_1762|M.smegmatis_MC2_155 LYGRTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWSWNTAIALVCG
Mb3321|M.bovis_AF2122/97 LYGRTIASERA-GHRLLETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
Rv3293|M.tuberculosis_H37Rv LYGRTIASERA-GHRLLETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
MMAR_1240|M.marinum_M LYGLTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
MUL_2647|M.ulcerans_Agy99 LYGLTIASERP-GHRLMETWHPLGVVGVITAFNFPVAVWAWNTAVALVCG
MAV_4265|M.avium_104 LYGRTIASERP-GHRLSETWHPLGVVGVITAFNFPVAVWAWNAALALVCG
TH_4531|M.thermoresistible__bu LEGAVVPTTPG-ETVDLTLLEPIGVVAVILTWNAPIGGWGMCVAPPLAAG
MLBr_02573|M.leprae_Br4923 LADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAG
* . : .*:*** .: .:* *: .* .* .*
Mvan_1643|M.vanbaalenii_PYR-1 DTVVWKPSELTPLTAVACQALLERACADVGAPAAVGRLVLGEREVGEKLV
Mflv_4799|M.gilvum_PYR-GCK NTVVWKPSELTPLTAVACQALLERACADVGAPPAVGRLVLGEREVGEKLV
MAB_3649|M.abscessus_ATCC_1997 DTVVWKPSELTPLTAVACQALLDRAAADVGAPPQVSRLIQGGREVGEQLV
MSMEG_1762|M.smegmatis_MC2_155 DTVVWKPSELTPLTAIACQALIERAAADVGAPAAVSRLVQGGREVGERLV
Mb3321|M.bovis_AF2122/97 DTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLV
Rv3293|M.tuberculosis_H37Rv DTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLV
MMAR_1240|M.marinum_M DTVLWKPSELAPLTALACQALLTRAAADVGAPPSVGAVVLGGAELGEQLV
MUL_2647|M.ulcerans_Agy99 DTVLWKPSELAPLTALACQALLTRAAADVGAPPSVGAVVLGGAELGEQLV
MAV_4265|M.avium_104 DTVVWKPSELTPLTALATQALIARAAADVGAPPGVSAVVLGDRELGELLV
TH_4531|M.thermoresistible__bu CCVILKPSELAPFTS----SFIARICEEEGMPPGVVTVLPGGPDAGEALV
MLBr_02573|M.leprae_Br4923 NVGLLKHASNVPQCALYLADVIARG----GFPEDCFQTLLISANGVEAIL
: * :. .* : .: * * * : : ::
Mvan_1643|M.vanbaalenii_PYR-1 DDPRVALVSATGSVRMGREVGPRVAARFGRALLELGGNNAAIVTPAADLD
Mflv_4799|M.gilvum_PYR-GCK DDPRVSLVSATGSVRMGREVGPRVAARFGRVLLELGGNNAAVVTPAADLD
MAB_3649|M.abscessus_ATCC_1997 DDPRIALVSATGSVRMGQQVGPRVAARFGRSLLELGGNNAAIVTPSADLD
MSMEG_1762|M.smegmatis_MC2_155 DDPRVALVSATGSVRMGREVGPRVAARFGKVLLELGGNNAAIVTPSADLD
Mb3321|M.bovis_AF2122/97 DDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLE
Rv3293|M.tuberculosis_H37Rv DDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLE
MMAR_1240|M.marinum_M DDPRIALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAVIVTPSADLD
MUL_2647|M.ulcerans_Agy99 DDPRIALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAVIVTPSADLD
MAV_4265|M.avium_104 DDERVALVSATGSVRMGRAVGPRVAARFGRVLLELGGNNAAVVTPSADLD
TH_4531|M.thermoresistible__bu RHPGVAKVSFTGGGPTGRKIAAACGEQLKPVLLELGGKSANIVFPDADLA
MLBr_02573|M.leprae_Br4923 RDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLD
. :: : **. *: :.. . .: :*****... :* * ***
Mvan_1643|M.vanbaalenii_PYR-1 LAVRGIVFSAAGTAGQRCTTLRRLIVHSSVADELVSRIVAAYKQLPVGDP
Mflv_4799|M.gilvum_PYR-GCK LAVRGIVFSAAGTAGQRCTTLRRLIVHSSIADELVSRIVKANEQLPVGDP
MAB_3649|M.abscessus_ATCC_1997 LAVRGIVFSAAGTAGQRCTTLRRLIVHRSIADGLVERIVHAYGQLPVGSP
MSMEG_1762|M.smegmatis_MC2_155 LAVRAIVFSAAGTAGQRCTTLRRLIVHSSVADEVVRRVVSAYQSLPIGDP
Mb3321|M.bovis_AF2122/97 LAVRCIVFAAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDP
Rv3293|M.tuberculosis_H37Rv LAVRGIVFAAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDP
MMAR_1240|M.marinum_M LAVRGIVFAAAGTAGQRCTSLRRLIVHSSVADDVVARVVAACRTLPVGDP
MUL_2647|M.ulcerans_Agy99 LAVRGIVFAAAGTAGQRCTSLRRLIVHSSVADDVVARVVAACRTLPVGDP
MAV_4265|M.avium_104 LAVRAVVFAAAGTAGQRCTTLRRLIVHHSVADEVVARVVSALRRLPIGDP
TH_4531|M.thermoresistible__bu KAA-ETAASVIFSAGQACTLPTRILVHESIYDEFTAMVAGALGQIPLGDP
MLBr_02573|M.leprae_Br4923 AAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDP
*. . . . ** * *::.* .: * .. .. : :*.*
Mvan_1643|M.vanbaalenii_PYR-1 FADRTLVGPLIHTASYRDMVLALQQATAE-GGTVLGGERVD--VGDE-GA
Mflv_4799|M.gilvum_PYR-GCK FRGGTLVGPLIHTRAYRDMVGALQQAQAE-GGEVIGGERVD--VGDE-GA
MAB_3649|M.abscessus_ATCC_1997 FDEQTLIGPLINDKAFRDMQDALETARAQ-GGTVVGGERRE--LGD--GS
MSMEG_1762|M.smegmatis_MC2_155 SAEGTLVGPLIHARAYRDMVGALEQARAD-GGTVHGGERHE--LGDEEGA
Mb3321|M.bovis_AF2122/97 SAPDTLVGPLIHEAAYRDMVAALERARTD-GGEVIGGDRRE---VGSPGA
Rv3293|M.tuberculosis_H37Rv SAPDTLVGPLIHEAAYRDMVAALERARTD-GGEVIGGDRRE---VGSPGA
MMAR_1240|M.marinum_M CDPATLIGPLIHETAYRDMLGALDQARAE-GGEVIDPNPRR---DGPAGG
MUL_2647|M.ulcerans_Agy99 CDPATLIGPLIHETAYRDMLGALDQARAE-GGEVIDPNPRR---DGPAGG
MAV_4265|M.avium_104 FEPGTLVGPLIHETAYRDMVGALESARAD-GGEVIDGDRRHPFAVEHPSS
TH_4531|M.thermoresistible__bu LDPATMMGPVISEAAVERILRTVDEATRDNGAELLTGGSRAG--GELASG
MLBr_02573|M.leprae_Br4923 TDPDTDVGPLATESGRAQVEQQVDAAAAA-GAVIRCGGKRP-----DRPG
* :**: . : :: * *. : .
Mvan_1643|M.vanbaalenii_PYR-1 FYVTPAVVR-MPAQSAVVHKETFAPILYVMTYETLDEAIALNNAVPQGLS
Mflv_4799|M.gilvum_PYR-GCK FYVTPAVVR-MPEQSAVVHQETFAPILYVLTYDTLDEAIALNNAVPQGLS
MAB_3649|M.abscessus_ATCC_1997 FYVTPAVVR-MPEQSDVVHRETFAPILYVLDYDTLDEAIALNNAVPQGLS
MSMEG_1762|M.smegmatis_MC2_155 FYVAPAVVV-MPAQTEIVHNETFAPILYVLTYDDLDEAIALNNAVPQGLS
Mb3321|M.bovis_AF2122/97 YYVAPAVVR-MPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLS
Rv3293|M.tuberculosis_H37Rv YYVAPAVVR-MPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLS
MMAR_1240|M.marinum_M YYVAPAVVR-MPAQTAIVATETFAPILYVLTYDDLDDAIALNNAVPQGLS
MUL_2647|M.ulcerans_Agy99 YYVAPAVVR-MPAQTAIVATETFAPILYVLTYDDLDDAIALNNAVPQGLS
MAV_4265|M.avium_104 YYVAPAVVR-MPAQTPIVATETFAPILYVLTYDRLDDAIALNNAVPQGLS
TH_4531|M.thermoresistible__bu YYIEPTLLGNVSPTSEVAQNEVFGPVTAAIRFSDEEEAVAIANGTPYGLA
MLBr_02573|M.leprae_Br4923 WFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLG
:: *::: :. : *.*.*: . ::*: : *..* **.
Mvan_1643|M.vanbaalenii_PYR-1 SSIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR
Mflv_4799|M.gilvum_PYR-GCK SSIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR
MAB_3649|M.abscessus_ATCC_1997 SAIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGR
MSMEG_1762|M.smegmatis_MC2_155 SAIFTTDVREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
Mb3321|M.bovis_AF2122/97 SSIFTTDLREAEHFLDQ--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
Rv3293|M.tuberculosis_H37Rv SSIFTTDLREAEHFLDQ--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
MMAR_1240|M.marinum_M SAIFTNDLREAERFLAA--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
MUL_2647|M.ulcerans_Agy99 SAFFTNDLREAERFLAA--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
MAV_4265|M.avium_104 SAIFTTDLREAERFLDE--SDCGIANVNIGTSGAEIGGAFGGEKQTGGGR
TH_4531|M.thermoresistible__bu GYVHTRDVSRVLRLASA--LEAGTVAFNGAGAPAGPGAPFGGYKESGYGR
MLBr_02573|M.leprae_Br4923 SNAWTQNESEQRHFIDN--IVAGQVFING-MTVSYPELPFGGIKRSGYGR
. * : . :: .* . .* : : .*** *.:* **
Mvan_1643|M.vanbaalenii_PYR-1 ESGSDSWKAYMRRATNTVNYSTELPLAQGVHFG
Mflv_4799|M.gilvum_PYR-GCK ESGSDSWKAYMRRATNTVNYSSDLPLAQGVEFG
MAB_3649|M.abscessus_ATCC_1997 ESGSDSWKAYMRRVTNTVNYSTELPLAQGVHFG
MSMEG_1762|M.smegmatis_MC2_155 ESGSDAWKAYMRRATNTVNYSSELPLAQGVHFG
Mb3321|M.bovis_AF2122/97 ESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG
Rv3293|M.tuberculosis_H37Rv ESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG
MMAR_1240|M.marinum_M ESGSDAWKAYMRRATNTINYSTELPLAQGVQFG
MUL_2647|M.ulcerans_Agy99 ESGSDAWKAYMRRATNTINYSTELPLAQSVQFG
MAV_4265|M.avium_104 ESGSDSWKAYMRQSTNTVNYSGALPLAQGVEFG
TH_4531|M.thermoresistible__bu EGGKLGVLEFVQHKTVSVALS------------
MLBr_02573|M.leprae_Br4923 ELSTHGIREFCNIKTVWIA--------------
* .. . : . * :