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MRPLRDTLSQLRLRELLNEVQDRVEQIVEGRDRLDGLLDAMLVVTSGLELDETLRTIVRTAIDLVDAQYG ALGVRGHDHELVEFIYQGIDEQSKELIGHLPEGRGVLGVLIDDPKPIRLDRISQHPASVGFPPNHPPMRT FLGVPVRIRDEVFGNLYLTEKADGQPFSEDDEVLVQALAAAAGIAIENARLYQQSKTRRSWIEATRDIGT EMLSGADPSKVFRLVADQSRLLSGAQSTLVAVRSDLDELDGRVDELVVVATAGDGPGVSLSAIPTHGSAI GEVFSTKTPVRFDTLELEPRHLAPGPALVLPLRATDTVAGVLVALRPEGAPPFNAEELDMMAAFVDQAAL AWQLATTQRQLRELDVLTDRDRIARDLHDHVIQRLFAVGLALQGTIPRARAPEVRERLTDCVDDLQQVIQ EIRTAIFDLHGGHGGSNRLRQRLDEAIAQFTASDVHTTVQFSGPLSVVDPALSDHAEAVVREAVSNAIRH SGATTLDVSVTAADELIIEVADDGCGMPADVTESGLTNLRQRAGDVGGTFTVESGDAGGTRLRWCAPLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1395 | - | - | 100% (559) | GAF sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_1413 | - | e-111 | 40.69% (553) | GAF sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_3797 | - | 3e-45 | 31.32% (380) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2052c | - | 0.0 | 67.62% (559) | histidine kinase response regulator |
| M. gilvum PYR-GCK | Mflv_3844 | - | 0.0 | 70.92% (557) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv2027c | - | 0.0 | 67.80% (559) | histidine kinase response regulator |
| M. leprae Br4923 | MLBr_02124 | - | 4e-05 | 27.82% (133) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3890c | - | 1e-157 | 56.55% (557) | histidine kinase response regulator |
| M. marinum M | MMAR_1517 | devS | 0.0 | 63.70% (562) | two-component sensor histidine kinase DevS |
| M. avium 104 | MAV_4108 | - | 1e-116 | 42.02% (545) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_5241 | - | 0.0 | 70.38% (557) | GAF family protein |
| M. thermoresistible (build 8) | TH_0388 | - | 3e-82 | 64.02% (239) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. ulcerans Agy99 | MUL_2422 | devS | 0.0 | 63.52% (562) | two component sensor histidine kinase DevS |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1395|M.vanbaalenii_PYR-1 ---------------------MRPLRDTLSQLRLRELLNEVQDRVEQIVE
Mflv_3844|M.gilvum_PYR-GCK ----MHDGAVADADDHRARDGARPVRTTLSQLRLRELLTEVQDRVEQIIR
Mb2052c|M.bovis_AF2122/97 ---------MTHPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVE
Rv2027c|M.tuberculosis_H37Rv ---------MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVE
MSMEG_5241|M.smegmatis_MC2_155 ------MGGVNGHHPRRDDDQRTPLRDTLSQLRLRELLSEVQDRVEQIVE
MMAR_1517|M.marinum_M MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 -------------MVEDVGAQPNRVTAELAHLQLRELLAEVQGRIEQIVD
MAV_4108|M.avium_104 ---------------------------------------MTGNRFDELAA
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
Mvan_1395|M.vanbaalenii_PYR-1 G-RDRLDGLLDAMLVVTSGLELDETLRTIVRTAIDLVDAQYGALGVRGHD
Mflv_3844|M.gilvum_PYR-GCK G-RDRLDGLVEAMLAVTSGLELDETLRTIVHTAIELVDAQYGALGVRGHD
Mb2052c|M.bovis_AF2122/97 G-RDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYD
Rv2027c|M.tuberculosis_H37Rv G-RDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYD
MSMEG_5241|M.smegmatis_MC2_155 G-RDRLDGLVEAMLVVTSGLELDVTLRTIVHTAIELVDARYGALGVRGED
MMAR_1517|M.marinum_M G-RDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEVHDRD
MUL_2422|M.ulcerans_Agy99 G-RDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRD
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 GTRGRMDALLDAVMAVSSGLELDATLREIVCAASELVSARYGALGVVGSD
MAV_4108|M.avium_104 A-RDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWH
MLBr_02124|M.leprae_Br4923 ------MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVG----------
Mvan_1395|M.vanbaalenii_PYR-1 HELVEFIYQGIDEQSKELIGHLPEGRGVLGVLIDDPKPIRLDRISQHPAS
Mflv_3844|M.gilvum_PYR-GCK QELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLEDISRHADS
Mb2052c|M.bovis_AF2122/97 HRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPAS
Rv2027c|M.tuberculosis_H37Rv HRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPAS
MSMEG_5241|M.smegmatis_MC2_155 HHLIEFIYEGITPEVREEIGPLPEGRGVLGVLIDDPKPIRLDDIRLHPAS
MMAR_1517|M.marinum_M KRVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQHPAS
MUL_2422|M.ulcerans_Agy99 KRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPAS
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 EKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAHPAS
MAV_4108|M.avium_104 ANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAA
MLBr_02124|M.leprae_Br4923 ----TVVWVGITNDRKERLDRKLDEAAGFAIPFVPRG---LDEIPRSPND
Mvan_1395|M.vanbaalenii_PYR-1 VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSEDDEVLVQAL
Mflv_3844|M.gilvum_PYR-GCK VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLVQAL
Mb2052c|M.bovis_AF2122/97 VGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQAL
Rv2027c|M.tuberculosis_H37Rv VGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQAL
MSMEG_5241|M.smegmatis_MC2_155 VGFPPNHPPMRTFLGVPVRTRDKVFGNLYLTEKTNGQPFSEDDEVLVQAL
MMAR_1517|M.marinum_M IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
MUL_2422|M.ulcerans_Agy99 IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 VGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVRAL
MAV_4108|M.avium_104 AGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARAL
MLBr_02124|M.leprae_Br4923 Q-----------DAIITVRRGNLVKSNFDITLPKLTNDYADTYLRGVRYR
Mvan_1395|M.vanbaalenii_PYR-1 AAAAGIAIENARLYQQSKTRRSWIEATRDIGTEMLSGADPSK-VFRLVAD
Mflv_3844|M.gilvum_PYR-GCK AAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPAG-VFRRVAD
Mb2052c|M.bovis_AF2122/97 AAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAM-VFRLIAE
Rv2027c|M.tuberculosis_H37Rv AAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAM-VFRLIAE
MSMEG_5241|M.smegmatis_MC2_155 AAAAGIAVDNARLYEESQARQAWIAATRDIGTQLLSGTDPAT-VFRLVAA
MMAR_1517|M.marinum_M AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
MUL_2422|M.ulcerans_Agy99 AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 AGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDPGK-ALHLVAS
MAV_4108|M.avium_104 AFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAE
MLBr_02124|M.leprae_Br4923 VRTVEIPAPEPTSIAVGATYDATVAETNNLHRRVLLICGFAIAAAAVFAW
Mvan_1395|M.vanbaalenii_PYR-1 QSRLLSGAQSTLVAVRSDLDELDG-RVDELVVVATAGDG-PGVSLSAIPT
Mflv_3844|M.gilvum_PYR-GCK RAQKLSGAAATLVAVPDDPDLPVG-EVAELTVAASAGET-IAAAHDPIPV
Mb2052c|M.bovis_AF2122/97 EALTLMAGAATLVAVPLDDEAPAC-EVDDLVIVEVAGEISPAVKQMTVAV
Rv2027c|M.tuberculosis_H37Rv EALTLMAGAATLVAVPLDDEAPAC-EVDDLVIVEVAGEISPAVKQMTVAV
MSMEG_5241|M.smegmatis_MC2_155 EALTLTGADGTLVAVPADPDASA---AEELVIVEVAGAVPAEVEASAIPV
MMAR_1517|M.marinum_M EALKLTSADAALVAVPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAV
MUL_2422|M.ulcerans_Agy99 EALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAV
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 SAALLAEADFAFIALPAGD---EE-DTAELVVAVCEGKGAEVLNDKLIPI
MAV_4108|M.avium_104 RACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPV
MLBr_02124|M.leprae_Br4923 LLAAFAVRPFKQLAQQTRSVDAGG-------------------EAPRVEV
Mvan_1395|M.vanbaalenii_PYR-1 HGSAIGEVFSTKTPVRFDTLELEP-RHL--APGPALVLPLRATDTVAGVL
Mflv_3844|M.gilvum_PYR-GCK AGTAIGDAFVHRTPGMTDRADIG--IGA--TVGPALLLPLRAPDAVPGVL
Mb2052c|M.bovis_AF2122/97 SGTSIGGVFHDRTPRRFDRLDLAVDGPV--EPGPALVLPLRAADTVAGVL
Rv2027c|M.tuberculosis_H37Rv SGTSIGGVFHDRTPRRFDRLDLAVDGPV--EPGPALVLPLRAADTVAGVL
MSMEG_5241|M.smegmatis_MC2_155 QDNAIGQAFRDRAPRRLDVLDGPG------LGGPALVLPLRATDTVAGVL
MMAR_1517|M.marinum_M AGTALAEVLLDSAPRQVDKIAVEGVDELG-DTGPALVLPLRATDAVAGVV
MUL_2422|M.ulcerans_Agy99 AGTALAEVLLDSAPRQVDKIAVEDVDELG-DMGPALVLPLRATDAVAGVV
TH_0388|M.thermoresistible__bu ------------------------------------------------VL
MAB_3890c|M.abscessus_ATCC_199 DGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTAGVL
MAV_4108|M.avium_104 RGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVGVI
MLBr_02124|M.leprae_Br4923 HG---------------------------------ATEAVEIAEAMRGML
::
Mvan_1395|M.vanbaalenii_PYR-1 VALRPEGAPPFNAEELDMMAAFVDQAALAWQLATTQRQLRELDVLTDRDR
Mflv_3844|M.gilvum_PYR-GCK IVLRSVGAQPFRSDELDMLAAFADQAAQAWQLASTQHRLRELGILTDRDR
Mb2052c|M.bovis_AF2122/97 VALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDR
Rv2027c|M.tuberculosis_H37Rv VALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDR
MSMEG_5241|M.smegmatis_MC2_155 VAVQGSGARPFTAEQLEMMTGFADQAAVAWQLASSQRRMSELDILADRDR
MMAR_1517|M.marinum_M VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVMTERDR
MUL_2422|M.ulcerans_Agy99 VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDR
TH_0388|M.thermoresistible__bu VVCRAEEGRPFTDEQLEILVTFADQAALAWQLAATQRRMRELDVLSDRDR
MAB_3890c|M.abscessus_ATCC_199 ILLRTVGAIAFDEEQLDMAASFAGQAALALEQAEVRLAKHELDVLADRDR
MAV_4108|M.avium_104 AIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERER
MLBr_02124|M.leprae_Br4923 QRIWNEQNR--TKEALASARDFAAVSSHELRTPLTAMRT-NLEVLATLD-
. * *. :: . :: ::: :
Mvan_1395|M.vanbaalenii_PYR-1 IARDLHDHVIQRLFAVGLALQGTIPRARAPEVRERLTDCVDDLQQVIQEI
Mflv_3844|M.gilvum_PYR-GCK IARDLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQSVIQEI
Mb2052c|M.bovis_AF2122/97 IARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEI
Rv2027c|M.tuberculosis_H37Rv IARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEI
MSMEG_5241|M.smegmatis_MC2_155 IARDLHDHVIQRLFAVGLSLQGTIPRARSAEVQQRIADCVDDLQAVISEI
MMAR_1517|M.marinum_M IARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEI
MUL_2422|M.ulcerans_Agy99 IARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEI
TH_0388|M.thermoresistible__bu IARDLHDHVIQRLFAVGLTLQGTIPRARSTEVQQRLSECIDDLQAVIGEI
MAB_3890c|M.abscessus_ATCC_199 IARDLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHIDQLHEVIQEI
MAV_4108|M.avium_104 IAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIEEI
MLBr_02124|M.leprae_Br4923 LADDQRKEVLGDVIRTQSRIEATLS-ALERLAQGELSTSDDHVPVDITEL
:* * :..*: :: ::.: : . : *.: * *:
Mvan_1395|M.vanbaalenii_PYR-1 RTAIFDLHGGHGGSNRLRQRLDEAIAQFTAS-DVHTTVQFSGPLSVVDPA
Mflv_3844|M.gilvum_PYR-GCK RTAIFDLHGGSSAVTRLRQRLDAAVAAFPES-GVRTSMQCAGPLSVVDAG
Mb2052c|M.bovis_AF2122/97 RSAIFDLHAGPSRATGLRHRLDKVIDQLAIP-ALHTTVQYTGPLSVVDTV
Rv2027c|M.tuberculosis_H37Rv RSAIFDLHAGPSRATGLRHRLDKVIDQLAIP-ALHTTVQYTGPLSVVDTV
MSMEG_5241|M.smegmatis_MC2_155 RTAIFDLHHTAPGGTRLRQRLDEAIAQFSGA-GLHTTSQFVGPLSVVDAE
MMAR_1517|M.marinum_M RTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGPLSVVDNV
MUL_2422|M.ulcerans_Agy99 RTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGPLSVVDNV
TH_0388|M.thermoresistible__bu RTTIFDLHGGPATGSQIRQRIGEAANQFSDA-GVRTRVQFAGPLSVISAV
MAB_3890c|M.abscessus_ATCC_199 RTAIFDLHTNDES---LRATLRSTINELTAETGLRVSVRMSGPLDVVPAS
MAV_4108|M.avium_104 RTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAE
MLBr_02124|M.leprae_Br4923 ----LDRAAHDATRSYPELKVSLVPSPTCIIVGLPAGLRLAVDNAVANAV
: . : . : . : .
Mvan_1395|M.vanbaalenii_PYR-1 LSDHAEAVVREAVSNAIRHSGATTLDVSVTAADELIIEVADDGCGMP--A
Mflv_3844|M.gilvum_PYR-GCK LADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGIA--A
Mb2052c|M.bovis_AF2122/97 LANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGIS--G
Rv2027c|M.tuberculosis_H37Rv LANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGIS--G
MSMEG_5241|M.smegmatis_MC2_155 LADHAEAVLREAVSNVVRHSGANELTVRVKVEDDLSIEVTDDGEGIS--G
MMAR_1517|M.marinum_M LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP--K
MUL_2422|M.ulcerans_Agy99 LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP--K
TH_0388|M.thermoresistible__bu LADHAEAVVREAVSNAVRHGGATDLSVDVSVDDDLTIEVTDNGRGFPE-G
MAB_3890c|M.abscessus_ATCC_199 TSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIGIP--D
MAV_4108|M.avium_104 LAEHAEAVTAEAVSNAVRHSGASRLTVQIGVADMFTLDVIDNGRGIAA-G
MLBr_02124|M.leprae_Br4923 KHGGATRVQLSAVSSRAGVEIAVDDNGSGVPEDERQVVFERFSRGSTASH
* * .***. * * : . . * .
Mvan_1395|M.vanbaalenii_PYR-1 DVTESGLTNLRQRAGDVGGTFTVES-GDAGGTRLRWCAPLR--
Mflv_3844|M.gilvum_PYR-GCK DVTGSGLANLARRAQDVGGSFSVRR-GAQVGTTLTWRAPLP--
Mb2052c|M.bovis_AF2122/97 DITESGLRNLRQRADDAGGEFTVEN-MPTGGTLLRWSAPLR--
Rv2027c|M.tuberculosis_H37Rv DITESGLRNLRQRADDAGGEFTVEN-MPTGGTLLRWSAPLR--
MSMEG_5241|M.smegmatis_MC2_155 PVTESGLSNLRQRADQCGGELRIID-RPGGGTILRWTAPLPD-
MMAR_1517|M.marinum_M TYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
MUL_2422|M.ulcerans_Agy99 TYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
TH_0388|M.thermoresistible__bu EVTESGLANLRHRARHAGGTLEVHN-RPDGGARLHWSVPLT--
MAB_3890c|M.abscessus_ATCC_199 VVARSGLSGLANRAAQSGGTFSVSA-MDTGGTRLVWSAPLP--
MAV_4108|M.avium_104 NTRRSGLANMTRRAEQLGGSCEISS-PPGGGTRVHWTAPLLDH
MLBr_02124|M.leprae_Br4923 SGSGLGLALVAQQAQLHGGTASLET-SPLGGARLLLRISAPS-
** : .:* ** : *: : .