For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_0388 | - | 100% (241) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS | |
| M. thermoresistible (build 8) | TH_4203 | - | 5e-12 | 26.02% (269) | PUTATIVE sensor histidine kinase |
| M. thermoresistible (build 8) | TH_1533 | - | 1e-10 | 27.37% (190) | two-component system sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 2e-81 | 65.56% (241) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_3844 | - | 3e-77 | 61.92% (239) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 2e-81 | 65.56% (241) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | MLBr_02124 | - | 2e-07 | 32.33% (133) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3890c | - | 7e-56 | 50.83% (240) | histidine kinase response regulator |
| M. marinum M | MMAR_1517 | devS | 1e-78 | 63.75% (240) | two-component sensor histidine kinase DevS |
| M. avium 104 | MAV_4108 | - | 4e-60 | 48.75% (240) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_5241 | - | 6e-87 | 66.95% (239) | GAF family protein |
| M. ulcerans Agy99 | MUL_2422 | devS | 9e-79 | 63.75% (240) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_1395 | - | 1e-82 | 64.02% (239) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MMAR_1517|M.marinum_M MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
Mflv_3844|M.gilvum_PYR-GCK ----MHDGAVADADDHRARDGARPVRTTLSQLRLRELLTEVQDRVEQIIR
Mvan_1395|M.vanbaalenii_PYR-1 ---------------------MRPLRDTLSQLRLRELLNEVQDRVEQIVE
MSMEG_5241|M.smegmatis_MC2_155 ------MGGVNGHHPRRDDDQRTPLRDTLSQLRLRELLSEVQDRVEQIVE
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 -------------MVEDVGAQPNRVTAELAHLQLRELLAEVQGRIEQIVD
MAV_4108|M.avium_104 ---------------------------------------MTGNRFDELAA
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 G-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQ
Rv3132c|M.tuberculosis_H37Rv G-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQ
MMAR_1517|M.marinum_M G-RDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEVHDRD
MUL_2422|M.ulcerans_Agy99 G-RDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRD
Mflv_3844|M.gilvum_PYR-GCK G-RDRLDGLVEAMLAVTSGLELDETLRTIVHTAIELVDAQYGALGVRGHD
Mvan_1395|M.vanbaalenii_PYR-1 G-RDRLDGLLDAMLVVTSGLELDETLRTIVRTAIDLVDAQYGALGVRGHD
MSMEG_5241|M.smegmatis_MC2_155 G-RDRLDGLVEAMLVVTSGLELDVTLRTIVHTAIELVDARYGALGVRGED
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 GTRGRMDALLDAVMAVSSGLELDATLREIVCAASELVSARYGALGVVGSD
MAV_4108|M.avium_104 A-RDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWH
MLBr_02124|M.leprae_Br4923 ------MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVG----------
Mb3156c|M.bovis_AF2122/97 HRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPAS
Rv3132c|M.tuberculosis_H37Rv HRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPAS
MMAR_1517|M.marinum_M KRVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQHPAS
MUL_2422|M.ulcerans_Agy99 KRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPAS
Mflv_3844|M.gilvum_PYR-GCK QELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLEDISRHADS
Mvan_1395|M.vanbaalenii_PYR-1 HELVEFIYQGIDEQSKELIGHLPEGRGVLGVLIDDPKPIRLDRISQHPAS
MSMEG_5241|M.smegmatis_MC2_155 HHLIEFIYEGITPEVREEIGPLPEGRGVLGVLIDDPKPIRLDDIRLHPAS
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 EKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAHPAS
MAV_4108|M.avium_104 ANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAA
MLBr_02124|M.leprae_Br4923 ----TVVWVGITNDRKERLDRKLDEAAGFAIPFVPRG---LDEIPRSPND
Mb3156c|M.bovis_AF2122/97 IGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQAL
Rv3132c|M.tuberculosis_H37Rv IGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQAL
MMAR_1517|M.marinum_M IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
MUL_2422|M.ulcerans_Agy99 IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
Mflv_3844|M.gilvum_PYR-GCK VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLVQAL
Mvan_1395|M.vanbaalenii_PYR-1 VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSEDDEVLVQAL
MSMEG_5241|M.smegmatis_MC2_155 VGFPPNHPPMRTFLGVPVRTRDKVFGNLYLTEKTNGQPFSEDDEVLVQAL
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 VGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVRAL
MAV_4108|M.avium_104 AGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARAL
MLBr_02124|M.leprae_Br4923 Q-----------DAIITVRRGNLVKSNFDITLPKLTNDYADTYLRGVRYR
Mb3156c|M.bovis_AF2122/97 AAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPAT-VFRLVAA
Rv3132c|M.tuberculosis_H37Rv AAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPAT-VFRLVAA
MMAR_1517|M.marinum_M AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
MUL_2422|M.ulcerans_Agy99 AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
Mflv_3844|M.gilvum_PYR-GCK AAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPAG-VFRRVAD
Mvan_1395|M.vanbaalenii_PYR-1 AAAAGIAIENARLYQQSKTRRSWIEATRDIGTEMLSGADPSK-VFRLVAD
MSMEG_5241|M.smegmatis_MC2_155 AAAAGIAVDNARLYEESQARQAWIAATRDIGTQLLSGTDPAT-VFRLVAA
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 AGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDPGK-ALHLVAS
MAV_4108|M.avium_104 AFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAE
MLBr_02124|M.leprae_Br4923 VRTVEIPAPEPTSIAVGATYDATVAETNNLHRRVLLICGFAIAAAAVFAW
Mb3156c|M.bovis_AF2122/97 EALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASTVGRTIPV
Rv3132c|M.tuberculosis_H37Rv EALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASIVGRTIPV
MMAR_1517|M.marinum_M EALKLTSADAALVAVPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAV
MUL_2422|M.ulcerans_Agy99 EALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAV
Mflv_3844|M.gilvum_PYR-GCK RAQKLSGAAATLVAVPDDPDLPVG-EVAELTVAASAGETIA-AAHDPIPV
Mvan_1395|M.vanbaalenii_PYR-1 QSRLLSGAQSTLVAVRSDLDELDG-RVDELVVVATAGDGPG-VSLSAIPT
MSMEG_5241|M.smegmatis_MC2_155 EALTLTGADGTLVAVPADPDASA---AEELVIVEVAGAVPAEVEASAIPV
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 SAALLAEADFAFIALPAGD---EE-DTAELVVAVCEGKGAEVLNDKLIPI
MAV_4108|M.avium_104 RACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPV
MLBr_02124|M.leprae_Br4923 LLAAFAVRPFKQLAQQTRSVDAGG-------------------EAPRVEV
Mb3156c|M.bovis_AF2122/97 AGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVAGVV
Rv3132c|M.tuberculosis_H37Rv AGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVAGVV
MMAR_1517|M.marinum_M AGTALAEVLLDSAPRQVDKIAVEGVD-ELGDTGPALVLPLRATDAVAGVV
MUL_2422|M.ulcerans_Agy99 AGTALAEVLLDSAPRQVDKIAVEDVD-ELGDMGPALVLPLRATDAVAGVV
Mflv_3844|M.gilvum_PYR-GCK AGTAIGDAFVHRTPGMTDRADIG-I---GATVGPALLLPLRAPDAVPGVL
Mvan_1395|M.vanbaalenii_PYR-1 HGSAIGEVFSTKTPVRFDTLELEPR---HLAPGPALVLPLRATDTVAGVL
MSMEG_5241|M.smegmatis_MC2_155 QDNAIGQAFRDRAPRRLDVLDGP------GLGGPALVLPLRATDTVAGVL
TH_0388|M.thermoresistible__bu ------------------------------------------------VL
MAB_3890c|M.abscessus_ATCC_199 DGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTAGVL
MAV_4108|M.avium_104 RGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVGVI
MLBr_02124|M.leprae_Br4923 HGATEAVEIAEAMRG-----------------------------------
Mb3156c|M.bovis_AF2122/97 VVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDR
Rv3132c|M.tuberculosis_H37Rv VVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDR
MMAR_1517|M.marinum_M VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVMTERDR
MUL_2422|M.ulcerans_Agy99 VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDR
Mflv_3844|M.gilvum_PYR-GCK IVLRSVGAQPFRSDELDMLAAFADQAAQAWQLASTQHRLRELGILTDRDR
Mvan_1395|M.vanbaalenii_PYR-1 VALRPEGAPPFNAEELDMMAAFVDQAALAWQLATTQRQLRELDVLTDRDR
MSMEG_5241|M.smegmatis_MC2_155 VAVQGSGARPFTAEQLEMMTGFADQAAVAWQLASSQRRMSELDILADRDR
TH_0388|M.thermoresistible__bu VVCRAEEGRPFTDEQLEILVTFADQAALAWQLAATQRRMRELDVLSDRDR
MAB_3890c|M.abscessus_ATCC_199 ILLRTVGAIAFDEEQLDMAASFAGQAALALEQAEVRLAKHELDVLADRDR
MAV_4108|M.avium_104 AIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERER
MLBr_02124|M.leprae_Br4923 MLQRIWNEQNRTKEALASARDFAAVSSHELRTPLTAMRT-NLEVLATLD-
. * *. :: . :* ::: :
Mb3156c|M.bovis_AF2122/97 IARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEI
Rv3132c|M.tuberculosis_H37Rv IARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEI
MMAR_1517|M.marinum_M IARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEI
MUL_2422|M.ulcerans_Agy99 IARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEI
Mflv_3844|M.gilvum_PYR-GCK IARDLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQSVIQEI
Mvan_1395|M.vanbaalenii_PYR-1 IARDLHDHVIQRLFAVGLALQGTIPRARAPEVRERLTDCVDDLQQVIQEI
MSMEG_5241|M.smegmatis_MC2_155 IARDLHDHVIQRLFAVGLSLQGTIPRARSAEVQQRIADCVDDLQAVISEI
TH_0388|M.thermoresistible__bu IARDLHDHVIQRLFAVGLTLQGTIPRARSTEVQQRLSECIDDLQAVIGEI
MAB_3890c|M.abscessus_ATCC_199 IARDLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHIDQLHEVIQEI
MAV_4108|M.avium_104 IAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIEEI
MLBr_02124|M.leprae_Br4923 LADDQRKEVLGDVIRTQSRIEATLS-ALERLAQGELSTSDDHVPVDITEL
:* * :..*: :: ::.: . .: *.: * *:
Mb3156c|M.bovis_AF2122/97 RTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSVVDSA
Rv3132c|M.tuberculosis_H37Rv RTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSVVDSA
MMAR_1517|M.marinum_M RTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSVVDNV
MUL_2422|M.ulcerans_Agy99 RTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSVVDNV
Mflv_3844|M.gilvum_PYR-GCK RTAIFDLHGGSSAVTRLRQRLDAAVAAFP-ESGVRTSMQCAGPLSVVDAG
Mvan_1395|M.vanbaalenii_PYR-1 RTAIFDLHGGHGGSNRLRQRLDEAIAQFT-ASDVHTTVQFSGPLSVVDPA
MSMEG_5241|M.smegmatis_MC2_155 RTAIFDLHHTAPGGTRLRQRLDEAIAQFS-GAGLHTTSQFVGPLSVVDAE
TH_0388|M.thermoresistible__bu RTTIFDLHGGPATGSQIRQRIGEAANQFS-DAGVRTRVQFAGPLSVISAV
MAB_3890c|M.abscessus_ATCC_199 RTAIFDLHTNDES---LRATLRSTINELTAETGLRVSVRMSGPLDVVPAS
MAV_4108|M.avium_104 RTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAE
MLBr_02124|M.leprae_Br4923 ----LDRAAHDATRSYPELKVSLVPSPTCIIVGLPAGLRLAVDNAVANAV
. : . .: . : .
Mb3156c|M.bovis_AF2122/97 LADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLP--D
Rv3132c|M.tuberculosis_H37Rv LADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLP--D
MMAR_1517|M.marinum_M LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP--K
MUL_2422|M.ulcerans_Agy99 LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP--K
Mflv_3844|M.gilvum_PYR-GCK LADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGIA--A
Mvan_1395|M.vanbaalenii_PYR-1 LSDHAEAVVREAVSNAIRHSGATTLDVSVTAADELIIEVADDGCGMP--A
MSMEG_5241|M.smegmatis_MC2_155 LADHAEAVLREAVSNVVRHSGANELTVRVKVEDDLSIEVTDDGEGIS--G
TH_0388|M.thermoresistible__bu LADHAEAVVREAVSNAVRHGGATDLSVDVSVDDDLTIEVTDNGRGFPE-G
MAB_3890c|M.abscessus_ATCC_199 TSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIGIP--D
MAV_4108|M.avium_104 LAEHAEAVTAEAVSNAVRHSGASRLTVQIGVADMFTLDVIDNGRGIAA-G
MLBr_02124|M.leprae_Br4923 KHGGATRVQLSAVSSRAGVEIAVDDNGSGVPEDERQVVFERFSRGSTASH
* * .***. * * : . . * .
Mb3156c|M.bovis_AF2122/97 EFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Rv3132c|M.tuberculosis_H37Rv EFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
MMAR_1517|M.marinum_M TYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
MUL_2422|M.ulcerans_Agy99 TYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
Mflv_3844|M.gilvum_PYR-GCK DVTGSGLANLARRAQDVGGSFSVRRGAQV-GTTLTWRAPLP--
Mvan_1395|M.vanbaalenii_PYR-1 DVTESGLTNLRQRAGDVGGTFTVESGDAG-GTRLRWCAPLR--
MSMEG_5241|M.smegmatis_MC2_155 PVTESGLSNLRQRADQCGGELRIIDRPGG-GTILRWTAPLPD-
TH_0388|M.thermoresistible__bu EVTESGLANLRHRARHAGGTLEVHNRPDG-GARLHWSVPLT--
MAB_3890c|M.abscessus_ATCC_199 VVARSGLSGLANRAAQSGGTFSVSAMDTG-GTRLVWSAPLP--
MAV_4108|M.avium_104 NTRRSGLANMTRRAEQLGGSCEISSPPGG-GTRVHWTAPLLDH
MLBr_02124|M.leprae_Br4923 SGSGLGLALVAQQAQLHGGTASLETSPLG-GARLLLRISAPS-
**: : .:* ** : *: : .