For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TSGEALDSVAESESTPAKKRHKNVLRRRPRFRASIQSKLMVLLLLTSIVSVAAIAAIVYQSGRTSLRAAA YERLTQLRESQKRAVETLFSDLTNSLVIYERGLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEF ITPVERTTGDKLDITALLPTSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGSAWSAANAQFNSYFREIVTR FDYDDAVLLDTRGNIVYTLSKDPDLGTNILTGPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVP TAWLVAPVEAGGKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDSRLFLQDPEE YRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRGQTGTVTSTDYTGSRELEAYAPLNVPDSDL HWSILATRNDSEAFAAVASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQKISAGDYEVNIP VKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLLLSMMPEPVVERYRLGEQTIAQEHQDVTVLFA DILGVDEISSGLSGNELVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPRTVDFALE MRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSSVVYDMWGAAVSLAYQMHSGSPQPGIYVTSQVYEA MRDVWQFTAAGTISVGGLEEPIYRLSERS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv2435c | - | - | 100% (730) | PROBABLE CYCLASE (ADENYLYL-OR GUANYLYL-)(ADENYLATE-OR GUANYLATE-) |
M. tuberculosis H37Rv | Rv1625c | cya | 9e-31 | 33.81% (210) | membrane-anchored adenylyl cyclase Cya (ATP |
M. tuberculosis H37Rv | Rv3645 | - | 1e-10 | 23.66% (317) | transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2461c | - | 0.0 | 100.00% (730) | putative cyclase (adenylyl-or guanylyl-)(adenylate-or |
M. gilvum PYR-GCK | Mflv_3576 | - | 6e-29 | 31.43% (210) | putative adenylate/guanylate cyclase |
M. leprae Br4923 | MLBr_02341 | - | 6e-15 | 32.40% (179) | putative regulatory protein |
M. abscessus ATCC 19977 | MAB_0490c | - | 7e-11 | 22.84% (289) | putative adenylate cyclase |
M. marinum M | MMAR_3757 | - | 0.0 | 81.31% (717) | adenylate or guanylate cyclase |
M. avium 104 | MAV_1745 | - | 0.0 | 65.25% (731) | adenylate and guanylate cyclase catalytic domain-containing |
M. smegmatis MC2 155 | MSMEG_3578 | - | 0.0 | 59.89% (703) | putative cyclase |
M. thermoresistible (build 8) | TH_2298 | - | 0.0 | 58.62% (708) | PROBABLE CYCLASE (ADENYLYL-OR GUANYLYL-)(ADENYLATE-OR |
M. ulcerans Agy99 | MUL_3698 | - | 0.0 | 60.69% (697) | adenylate or guanylate cyclase |
M. vanbaalenii PYR-1 | Mvan_2839 | - | 8e-28 | 26.62% (278) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2435c|M.tuberculosis_H37Rv MTSGEALDSVAESESTPAKKRHKNVLRR--RPRFRASIQSKLMVLLLLTS Mb2461c|M.bovis_AF2122/97 MTSGEALDSVAESESTPAKKRHKNVLRR--RPRFRASIQSKLMVLLLLTS MMAR_3757|M.marinum_M -----------MVEGAPAHDGAKGTRRR--RPRFRVSIQSKLMVLLLLSS MAV_1745|M.avium_104 MTTSELTDAESDIAPAPAPQPAKRTRRTPLRSRFRFGIQSKILITMLLSS MUL_3698|M.ulcerans_Agy99 ------------------------MLRF-----LRVGIPAKLLVTLLVCS MSMEG_3578|M.smegmatis_MC2_155 -------------------------MLS------RISIQSKLLAMLLVTS TH_2298|M.thermoresistible__bu ---------------MAIRRKPRRHWTP------RFSIQSKLLMMLLTTS MAB_0490c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 ---------------------------------MTTALVCVACGAELRSI Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2435c|M.tuberculosis_H37Rv IVSVAAIAAIVYQSGRTSLRAAAYERLTQLRESQKRAVETLFSDLTNSLV Mb2461c|M.bovis_AF2122/97 IVSVAAIAAIVYQSGRTSLRAAAYERLTQLRESQKRAVETLFSDLTNSLV MMAR_3757|M.marinum_M IVSVAAIVAVGFHTGRSSLSAAAYGRLTQLRESQLRAVETLFSDLTNSLV MAV_1745|M.avium_104 ILGVAVIGLIGAVSGRNALRQVESERLIELREGQKRAVQALFREVTNSLI MUL_3698|M.ulcerans_Agy99 ILSVAVVGVIGYVSGRNALQRVAVERLHQLREAQKRQVEALFSELTKSVM MSMEG_3578|M.smegmatis_MC2_155 VLSAAVVGFIGYQSGRSSLRDSVFDRLTEIRTAQARQLETQFRSFRNSLV TH_2298|M.thermoresistible__bu VLAVAVVGFIGYQSGRSSLRASAFDGLIEIRTSQARELETLFSDLTNSLV MAB_0490c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 AKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLERLREIMT Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2435c|M.tuberculosis_H37Rv IYERGLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEFITPVERT Mb2461c|M.bovis_AF2122/97 IYERGLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEFITPVERT MMAR_3757|M.marinum_M IYARGLTVIDAVAQFTAGFDQLADATISPAQQESLVNYYNDQLIKPVEHL MAV_1745|M.avium_104 VWSGGFTINEATAALTTGFAQLANATITPAQQQQLVNYYDNQMLKPIKHA MUL_3698|M.ulcerans_Agy99 VYSNGMSANEATAALTDGFAQLANATVDPVQQQAIVDYYVNELIKPIDQA MSMEG_3578|M.smegmatis_MC2_155 IYTRGTTAIEAARAFTAGFDQLGDATISPAQQKAITDWYENQFSATTEHS TH_2298|M.thermoresistible__bu IYSRGDTAAAAVTAFTDAFDELHDATVTPAQHRAIVDYYERHFGGDTTAT MAB_0490c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 ELVSRAAGVIERYGGTVDKFTGDGIMAIFGAPTALEDHALRACLAALGVQ Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2435c|M.tuberculosis_H37Rv T------GDKLDITALLPTSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGS Mb2461c|M.bovis_AF2122/97 T------GDKLDITALLPTSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGS MMAR_3757|M.marinum_M T------GTKLDLEALLPTSPAQKYLQAYYTAPFTSDQDSMRLDDAGDGS MAV_1745|M.avium_104 T------GDSIDINAVLPNSNAQKYVQAYYTAAPRPTPDSLPVQDAGDGS MUL_3698|M.ulcerans_Agy99 T------GHELDLEAVLSASPAQTYLQAYYTAPFSSSSESMRFNNAGDGS MSMEG_3578|M.smegmatis_MC2_155 DAADNLDGNEVDVEALLPSSNPQKYLQALYTAPFTDWDKAIENDDAGDGS TH_2298|M.thermoresistible__bu -------GSRLRVEALLPSGSAQRYLQAHYTAPFSDWDAAIDNDDAGDGS MAB_0490c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 EKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTAVGVQVGM Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2435c|M.tuberculosis_H37Rv AWSAANAQFNSYFREIVTRFDYDDAVLLDTRGNIVYTLSKDPDLGTNILT Mb2461c|M.bovis_AF2122/97 AWSAANAQFNSYFREIVTRFDYDDAVLLDTRGNIVYTLSKDPDLGTNILT MMAR_3757|M.marinum_M AWSAANAEFNGYFREIVTRFDYDDAVLLDTRGNIVYSLSKDPDLGTNILT MAV_1745|M.avium_104 AWSAANARFDFYVRDIATRFDYRDALLLDTQGNVVYSVMKGPDLGTNILT MUL_3698|M.ulcerans_Agy99 AWSAANARFNDFFRGIVTRFQYRDALLLDLQGNVVYSVNEGPDLGTNLFT MSMEG_3578|M.smegmatis_MC2_155 GWSAANALFNGFFREIVTRSGFDDALLLDTRGNVVYTAYKGSDLGTNIYT TH_2298|M.thermoresistible__bu AWSAANARFHDFFREIVERFEFEDALLIDTRGNVVYSAYKGVDLGTNLHT MAB_0490c|M.abscessus_ATCC_199 ---MTGAEGRPDRRPLARAARYSRWVMRTPWPLFIMGIAQSNLVGALFVL MLBr_02341|M.leprae_Br4923 AQRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLL Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------MRPVCVP Rv2435c|M.tuberculosis_H37Rv GPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVPTAWLVAPVEAG Mb2461c|M.bovis_AF2122/97 GPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVPTAWLVAPVEAG MMAR_3757|M.marinum_M GPYRESNLRDAYLRALGANAVDFTWITDFEPYQPQLDAATAWLVSPVLQG MAV_1745|M.avium_104 GPYRESKLREAYQKALASNDVDFVWITDFQPYQPQLDAPTAWVVSPVGMN MUL_3698|M.ulcerans_Agy99 GPYRETNLRTAYQKALASNEIDFVWITDFQRYQPEVDAPTAWLVSPVGVD MSMEG_3578|M.smegmatis_MC2_155 GPYKGGELSEAYREALNSNTVDYVAVTDFGIYQPSG-TPTAWMVSPIGGG TH_2298|M.thermoresistible__bu GPYRETALSEAYRKALGSNMVDHVGLTDFSTYQPTS-EPTAWMVSPVGTG MAB_0490c|M.abscessus_ATCC_199 GFLRFG--------LPPSDRVELTELGPTRLIILGFSLFILFVVGAIVST MLBr_02341|M.leprae_Br4923 RVAEPRQPTWFSESTLVGREWELATLAAMLDRSIGGRGSVVGLVGPAGIG Mflv_3576|M.gilvum_PYR-GCK ------------------MGRRQSVLMIAGWIAAAVSAAFGAFQLTLGGS Mvan_2839|M.vanbaalenii_PYR-1 EVTLGRRAWSPSRHRHERVARRQRVLMIASWIAAAASVGFGVFQLTFGGP Rv2435c|M.tuberculosis_H37Rv GKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDS Mb2461c|M.bovis_AF2122/97 GKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDS MMAR_3757|M.marinum_M GRTEGVLALPLPIAKINKMMTADKNWQAAGMGTGTETYLAGPDNLMRSDS MAV_1745|M.avium_104 GRIEGVMALPVPAAKINKIMTAGGHWEAAGMGPATETYLAGPDDLMRSDS MUL_3698|M.ulcerans_Agy99 GKLQGVMALALPPTNLNQIMNANEKWEAVGMGRSTETYLAGSDNLMRSDS MSMEG_3578|M.smegmatis_MC2_155 GRIEGVLALQFPISVVNQLMTMDGKWEESGLGETGETYLVGPDGLMRSDS TH_2298|M.thermoresistible__bu GRILGALALQFPIDKINRVMTADRQWESVGLGRTGETYLVGTDDLMRSDS MAB_0490c|M.abscessus_ATCC_199 YLLLPVLRWQYRSPDFESEGSEAVRVRALQMPFYRTVISVAT-WLVGGAI MLBr_02341|M.leprae_Br4923 KTRLVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISGLD . Mflv_3576|M.gilvum_PYR-GCK LWWLGAVN------VLCALVFLWIPRLCPLG--ELLAPLTFVTFAYMSVT Mvan_2839|M.vanbaalenii_PYR-1 LWWLGAVN------IGCGVVFLAIPRLCPLG--ELIAPLTFVVFAYTSVG Rv2435c|M.tuberculosis_H37Rv RLFLQDPEEYRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRG Mb2461c|M.bovis_AF2122/97 RLFLQDPEEYRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRG MMAR_3757|M.marinum_M RLFLQDPEEYRRQAVAAGTSPEVVNRAIQLGSTVLLQPVATAGLREAQRG MAV_1745|M.avium_104 RVFVEDPQQYRRDAIDAGTPPDVVDRAIHLGGTTLVQPVATAGLRAAQRG MUL_3698|M.ulcerans_Agy99 RLFLESPDEYRREALAGGTREDVVNKAMWLGTTVLVQPVPSAGLRAALRG MSMEG_3578|M.smegmatis_MC2_155 RLFLENPEQFKADVIEAGTPPGVAEQSILHGGTTLVQPVSDEASKLAGQG TH_2298|M.thermoresistible__bu RLFLEDPEQFKRAVVEAGTPPTVAEESLRSGGTTLVQPIRNEAVDRAQRG MAB_0490c|M.abscessus_ATCC_199 FVAVTWSSTHSSVLVAAFATVLGATTTSIIGYLQSERVLRPVAIQALRRG MLBr_02341|M.leprae_Br4923 DRSARARVREQIPDADTQDLLLLDDLLGIADPAVELPRLDPDARRRRLTA . : Mflv_3576|M.gilvum_PYR-GCK FF----CYTIGTGSG-----------------MQFYFLVAASLVLLVLGI Mvan_2839|M.vanbaalenii_PYR-1 FI----CYTIGTGSG-----------------LQFYFLVAASLVVLVLGI Rv2435c|M.tuberculosis_H37Rv QT----GTVTSTDYTGSRELEAYAPLNVPDSDLHWSILATRNDSEAFAAV Mb2461c|M.bovis_AF2122/97 QT----GTVTSTDYTGSRELEAYAPLNVPDSDLHWSILATRNDSEAFAAV MMAR_3757|M.marinum_M QT----GTVSAVDYTGNRELEAFAPLNIPNSDLHWSILATNDDSAAFAAA MAV_1745|M.avium_104 ET----GVVTATDYMGNRELEAYAPLNIPNSDLHWSILATRDNSDAFARL MUL_3698|M.ulcerans_Agy99 QS----GITKDTDYLGNRELEAYAPLDVPNSDLRWAILATRDDWDAYERL MSMEG_3578|M.smegmatis_MC2_155 QS----GSIIERDYLGQETLQAYAPLDLTG--LDWSVVAKIDTAEAFAPV TH_2298|M.thermoresistible__bu QT----GTLIGTDYLGREALQSYAPVDLPG--LNWSIVAEKDTAEAFGPV MAB_0490c|M.abscessus_ATCC_199 VP----ENVTAPGVIVRQILTWALSTGVPILAIVLTVVGQRAG-YLKSNA MLBr_02341|M.leprae_Br4923 LINVAQLALSRPAVFVVEDVHWIDEVSDSMLADFLAVIPQTRSMALVTYR .: Mflv_3576|M.gilvum_PYR-GCK ERVALAAVIAGVGVVITVVLELTVPEDRGLGPSWTLTAG----------- Mvan_2839|M.vanbaalenii_PYR-1 ERIALAAAIAAAGVIITIVLELTVPDDRGLGPSWTLTAG----------- Rv2435c|M.tuberculosis_H37Rv ASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQKI------- Mb2461c|M.bovis_AF2122/97 ASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQKI------- MMAR_3757|M.marinum_M AAFSKALVLVTVAMIVIICVFSMLIAQLMVRPIRRLEAGTEKI------- MAV_1745|M.avium_104 GRFSKNLVIAVTAMIFVICVASMFVAQAAVRPVRRLEEGTRKI------- MUL_3698|M.ulcerans_Agy99 SSFGRTVVLAVAGITLFICVVSMVLAKLLVRPIRRLEAGTEKI------- MSMEG_3578|M.smegmatis_MC2_155 TKFTRTLVLSTVAMIFAVCIAAILLARVFVRPIRRLEAGAQQI------- TH_2298|M.thermoresistible__bu VEFTRTLVLSTVSIVFAVCLAAMLLARIFVRPVRRLEAGVRRV------- MAB_0490c|M.abscessus_ATCC_199 DNLTGSILILAIIALAIGLMGTLLVATSIADPLRQLRWALSEV------- MLBr_02341|M.leprae_Br4923 PEYHGALRHVVGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITER . * . Mflv_3576|M.gilvum_PYR-GCK -----FISAVTSSAVMIVATIWYTLREIER----AESAMENEYERSERLL Mvan_2839|M.vanbaalenii_PYR-1 -----FISAVVSSVVIIVATIWYTLREIDR----AEAAMAAEYERSEELL Rv2435c|M.tuberculosis_H37Rv -SAGDYEVNIPVKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLL Mb2461c|M.bovis_AF2122/97 -SAGDYEVNIPVKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLL MMAR_3757|M.marinum_M -SGGDYDVAIPVKSRDEIGDLTAAFNEMSRSLNIKEDLLNEQRRENDRLL MAV_1745|M.avium_104 -SSGDYDINIPVRARDEIGDLTAAFNEMSRNLAIKEELLNEQRRENDRLL MUL_3698|M.ulcerans_Agy99 -RSGDYEVTVPVKSRDELGDLTAAFNEMSSNLKVKDQLLTEQRSQNEQLL MSMEG_3578|M.smegmatis_MC2_155 -SAGDYGVALPVVSRDEFGDLTVAFNEMSRNLRIKEDLLDEQRKENDRLL TH_2298|M.thermoresistible__bu -ATGDYHVRLPVTSHDEFGDLTAAFNDMSRNLATKEELLAEQRRENDRLL MAB_0490c|M.abscessus_ATCC_199 -QRGNYNAHVPIYDASELGLLQAGFNDMVRDLG--------ERQRLRDLF MLBr_02341|M.leprae_Br4923 AAGNPFFAQEITRELAERGVLTGERGRYACSTDVAEVCVPATLQATIAAR : . : Mflv_3576|M.gilvum_PYR-GCK ANILPATIAERLKEPTRTVIADKYDDASILFADIAGYTKRASDTAPAE-- Mvan_2839|M.vanbaalenii_PYR-1 ANILPATIADRLKEPTRTVIADKYDDASILFADIAGYTKRASETPPSE-- Rv2435c|M.tuberculosis_H37Rv LSMMPEPVVERYRL-GEQTIAQEHQDVTVLFADILGVDEISSGLSGNE-- Mb2461c|M.bovis_AF2122/97 LSMMPEPVVERYRL-GEQTIAQEHQDVTVLFADILGVDEISSGLSGNE-- MMAR_3757|M.marinum_M LSMMPEPVVQRYRE-GEQTIAQEHQDVTVIFADILGLDEVSRSLSGNE-- MAV_1745|M.avium_104 LALMPESVLQRYRE-GEETIAQKHQDVAIIYADIVGLDELFTEMPEAQ-- MUL_3698|M.ulcerans_Agy99 LALMPEPVVQRYRA-DGEVIAEEHQDVTVIFAELIGLEEISDGLSGDE-- MSMEG_3578|M.smegmatis_MC2_155 LSLMPEPVVQRYRE-GEETIAQDHQNVTVLFADLMGLDRLSASMSSDE-- TH_2298|M.thermoresistible__bu LSLMPEPVVQRYRD-GEQTIAQDHQDVTVIFADIVGLDEVSFNLPSAE-- MAB_0490c|M.abscessus_ATCC_199 GRYVGEDVARRALEYGTELGGQE-RSVAVLFVDLVGSTQLASTRGPAV-- MLBr_02341|M.leprae_Br4923 IDRLSPPAKQLLVAAAVIGFRFGSDLLASLGIDLSVDELIDANLVDQVRF : : : :: Mflv_3576|M.gilvum_PYR-GCK LVRFLDLLYTDLDALVDRHGLEKVKTSGDSYMVVSGVPTPRPDHLEALAT Mvan_2839|M.vanbaalenii_PYR-1 LVRFLDRLYTDLDALVDRHGLEKVKTSGDSYMVVSGVPNPRADHLEALAL Rv2435c|M.tuberculosis_H37Rv LVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPRTVD Mb2461c|M.bovis_AF2122/97 LVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPRTVD MMAR_3757|M.marinum_M LIAIVDDLFRQFDSAAESLGVERIRTLHNGYLASCGVTTPRLDNVARTVA MAV_1745|M.avium_104 LVGTVDELFRQFDSAAETLGVERIRTFHNGYLASCGVVTPRLDSIHRAVD MUL_3698|M.ulcerans_Agy99 LVGIVDELFRQFDSAAQSLGVEPIRTFHNGYLAACGATTPRLDNVHRGIE MSMEG_3578|M.smegmatis_MC2_155 HLSIVNKLVRQFDAAAESLGVERVRTLHNGYLASCGLTVPRLDNVRRTVD TH_2298|M.thermoresistible__bu AVPIVNELIRQFDAAADHHGVERVRTMHNGYIASCGLSVPRLDNVRRTVD MAB_0490c|M.abscessus_ATCC_199 VVRVLNEFFRVIVDTVNKHGGFVNKFQGDAALAIFGAPIDHPDGAAAALA MLBr_02341|M.leprae_Br4923 TAPVEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEARAPHSVDQHAV : : . . . . Mflv_3576|M.gilvum_PYR-GCK LALDMSEAVADLKDPRGRDVPLRIGMAMGPVVAGVVGAKK--------FF Mvan_2839|M.vanbaalenii_PYR-1 LALDMADAVADLKDPQGHDVPLRIGMASGPVVAGVVGAKK--------FF Rv2435c|M.tuberculosis_H37Rv FALEMRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSS--------VV Mb2461c|M.bovis_AF2122/97 FALEMRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSS--------VV MMAR_3757|M.marinum_M FALEMQRIIERFNHQSGHQLRLRAGINTGNVISGLVGRTS--------VV MAV_1745|M.avium_104 FALEIGRIIDRFNSQTGHQLGLRIGVNTGNVVSGLVGRSG--------LV MUL_3698|M.ulcerans_Agy99 FALEIELIVNRFANQSQHPLRVRVGVTTGRVVSGRVGRSN--------LA MSMEG_3578|M.smegmatis_MC2_155 FAFEMQRIVDRFRGETGYDLRLRAGIDTGTVSSGLVGRSS--------LA TH_2298|M.thermoresistible__bu FALDLQRIIDRFTRETGHRLELRAGIDTGTVKSGLVDRSR--------LA MAB_0490c|M.abscessus_ATCC_199 AARELSGELTNVLGSND----FGIGVSAGRAIAGHIGAQAR-------FE MLBr_02341|M.leprae_Br4923 LIAEHLEAAGDLHAAYGWHMRAAAWATNQDVRAARVSWEHATKIADALTA : . . :. :. Mflv_3576|M.gilvum_PYR-GCK YDVWGDAVNVASRMETTDEE--GRIQVPDNVYQRLRH--AFVLEERGLID Mvan_2839|M.vanbaalenii_PYR-1 YDVWGDAVNVASRMETTDVE--GRIQVPDNVYERLRD--RFVLEERGVVD Rv2435c|M.tuberculosis_H37Rv YDMWGAAVSLAYQMHSGSPQ--PGIYVTSQVYEAMRD--VWQFTAAGTIS Mb2461c|M.bovis_AF2122/97 YDMWGAAVSLAYQMHSGSPQ--PGIYVTSQVYEAMRD--VWQFTAAGTIS MMAR_3757|M.marinum_M YDMWGAAVSTAYQMHSGSPQ--PGIYVTSQVYEAMRD--ERQFAPAGTIA MAV_1745|M.avium_104 YDMWGGAVSLAYQMHSGSPQ--PGIYVSSQVYEAMRD--VRQFAPAGTIS MUL_3698|M.ulcerans_Agy99 YDMWGGAVQMAYRMLGHLSD--PGIYVSARVHDAMRE--IWTFTPAGAIS MSMEG_3578|M.smegmatis_MC2_155 YDMWGAAVDLAYQVQRGMPQ--PGVYVTDQVHDAVRD--IRQFTAVGSVT TH_2298|M.thermoresistible__bu YDMWGSAVNIAYQVQTGTAK--PGIFVTTRVRDVLRD--TYRFEQAGQID MAB_0490c|M.abscessus_ATCC_199 YTVIGDPVNEAARLTELAKNEPGNVLASASAVMEARDEEALRWDVGETVE MLBr_02341|M.leprae_Br4923 EDPHRAAMCIAPRTRLCGIAWRGRFNSSSGFDEVRQLCNATGDKAPLAVA .: * : . . : : Mflv_3576|M.gilvum_PYR-GCK VKGKGPMHTWYLVGHRARAVTPSSSPP Mvan_2839|M.vanbaalenii_PYR-1 VKGKGPMHTWYLVAHRAEAVTPSGSPT Rv2435c|M.tuberculosis_H37Rv VGGL-EEPIYRLSERS----------- Mb2461c|M.bovis_AF2122/97 VGGL-EEPIYRLSERS----------- MMAR_3757|M.marinum_M VGGA-EQQIYRMSEQS----------- MAV_1745|M.avium_104 VGGT-DQAIYRLLER------------ MUL_3698|M.ulcerans_Agy99 VRGS-QQQIWQVSERR----------- MSMEG_3578|M.smegmatis_MC2_155 VDGT-ERPIWRLSERQS---------- TH_2298|M.thermoresistible__bu IDGA-AEPVWRLTEQRS---------- MAB_0490c|M.abscessus_ATCC_199 LRGRTVSTQVARPRHG----------- MLBr_02341|M.leprae_Br4923 TVGPAIDHVYQDRLH------------ * :