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M. tuberculosis H37Rv Rv2435c (-)

annotation: PROBABLE CYCLASE (ADENYLYL-OR GUANYLYL-)(ADENYLATE-OR GUANYLATE-)
coordinates: 2730557 - 2732749
length: 730

TSGEALDSVAESESTPAKKRHKNVLRRRPRFRASIQSKLMVLLLLTSIVSVAAIAAIVYQSGRTSLRAAA
YERLTQLRESQKRAVETLFSDLTNSLVIYERGLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEF
ITPVERTTGDKLDITALLPTSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGSAWSAANAQFNSYFREIVTR
FDYDDAVLLDTRGNIVYTLSKDPDLGTNILTGPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVP
TAWLVAPVEAGGKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDSRLFLQDPEE
YRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRGQTGTVTSTDYTGSRELEAYAPLNVPDSDL
HWSILATRNDSEAFAAVASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQKISAGDYEVNIP
VKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLLLSMMPEPVVERYRLGEQTIAQEHQDVTVLFA
DILGVDEISSGLSGNELVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPRTVDFALE
MRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSSVVYDMWGAAVSLAYQMHSGSPQPGIYVTSQVYEA
MRDVWQFTAAGTISVGGLEEPIYRLSERS*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2435c--100% (730)PROBABLE CYCLASE (ADENYLYL-OR GUANYLYL-)(ADENYLATE-OR GUANYLATE-)
M. tuberculosis H37RvRv1625ccya9e-3133.81% (210) membrane-anchored adenylyl cyclase Cya (ATP
M. tuberculosis H37RvRv3645-1e-1023.66% (317) transmembrane protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2461c-0.0100.00% (730) putative cyclase (adenylyl-or guanylyl-)(adenylate-or
M. gilvum PYR-GCKMflv_3576-6e-2931.43% (210) putative adenylate/guanylate cyclase
M. leprae Br4923MLBr_02341-6e-1532.40% (179) putative regulatory protein
M. abscessus ATCC 19977MAB_0490c-7e-1122.84% (289) putative adenylate cyclase
M. marinum MMMAR_3757-0.081.31% (717) adenylate or guanylate cyclase
M. avium 104MAV_1745-0.065.25% (731) adenylate and guanylate cyclase catalytic domain-containing
M. smegmatis MC2 155MSMEG_3578-0.059.89% (703) putative cyclase
M. thermoresistible (build 8)TH_2298-0.058.62% (708) PROBABLE CYCLASE (ADENYLYL-OR GUANYLYL-)(ADENYLATE-OR
M. ulcerans Agy99MUL_3698-0.060.69% (697) adenylate or guanylate cyclase
M. vanbaalenii PYR-1Mvan_2839-8e-2826.62% (278) putative adenylate/guanylate cyclase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2435c|M.tuberculosis_H37Rv        MTSGEALDSVAESESTPAKKRHKNVLRR--RPRFRASIQSKLMVLLLLTS
Mb2461c|M.bovis_AF2122/97           MTSGEALDSVAESESTPAKKRHKNVLRR--RPRFRASIQSKLMVLLLLTS
MMAR_3757|M.marinum_M               -----------MVEGAPAHDGAKGTRRR--RPRFRVSIQSKLMVLLLLSS
MAV_1745|M.avium_104                MTTSELTDAESDIAPAPAPQPAKRTRRTPLRSRFRFGIQSKILITMLLSS
MUL_3698|M.ulcerans_Agy99           ------------------------MLRF-----LRVGIPAKLLVTLLVCS
MSMEG_3578|M.smegmatis_MC2_155      -------------------------MLS------RISIQSKLLAMLLVTS
TH_2298|M.thermoresistible__bu      ---------------MAIRRKPRRHWTP------RFSIQSKLLMMLLTTS
MAB_0490c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02341|M.leprae_Br4923          ---------------------------------MTTALVCVACGAELRSI
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2435c|M.tuberculosis_H37Rv        IVSVAAIAAIVYQSGRTSLRAAAYERLTQLRESQKRAVETLFSDLTNSLV
Mb2461c|M.bovis_AF2122/97           IVSVAAIAAIVYQSGRTSLRAAAYERLTQLRESQKRAVETLFSDLTNSLV
MMAR_3757|M.marinum_M               IVSVAAIVAVGFHTGRSSLSAAAYGRLTQLRESQLRAVETLFSDLTNSLV
MAV_1745|M.avium_104                ILGVAVIGLIGAVSGRNALRQVESERLIELREGQKRAVQALFREVTNSLI
MUL_3698|M.ulcerans_Agy99           ILSVAVVGVIGYVSGRNALQRVAVERLHQLREAQKRQVEALFSELTKSVM
MSMEG_3578|M.smegmatis_MC2_155      VLSAAVVGFIGYQSGRSSLRDSVFDRLTEIRTAQARQLETQFRSFRNSLV
TH_2298|M.thermoresistible__bu      VLAVAVVGFIGYQSGRSSLRASAFDGLIEIRTSQARELETLFSDLTNSLV
MAB_0490c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02341|M.leprae_Br4923          AKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLERLREIMT
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2435c|M.tuberculosis_H37Rv        IYERGLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEFITPVERT
Mb2461c|M.bovis_AF2122/97           IYERGLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEFITPVERT
MMAR_3757|M.marinum_M               IYARGLTVIDAVAQFTAGFDQLADATISPAQQESLVNYYNDQLIKPVEHL
MAV_1745|M.avium_104                VWSGGFTINEATAALTTGFAQLANATITPAQQQQLVNYYDNQMLKPIKHA
MUL_3698|M.ulcerans_Agy99           VYSNGMSANEATAALTDGFAQLANATVDPVQQQAIVDYYVNELIKPIDQA
MSMEG_3578|M.smegmatis_MC2_155      IYTRGTTAIEAARAFTAGFDQLGDATISPAQQKAITDWYENQFSATTEHS
TH_2298|M.thermoresistible__bu      IYSRGDTAAAAVTAFTDAFDELHDATVTPAQHRAIVDYYERHFGGDTTAT
MAB_0490c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02341|M.leprae_Br4923          ELVSRAAGVIERYGGTVDKFTGDGIMAIFGAPTALEDHALRACLAALGVQ
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2435c|M.tuberculosis_H37Rv        T------GDKLDITALLPTSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGS
Mb2461c|M.bovis_AF2122/97           T------GDKLDITALLPTSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGS
MMAR_3757|M.marinum_M               T------GTKLDLEALLPTSPAQKYLQAYYTAPFTSDQDSMRLDDAGDGS
MAV_1745|M.avium_104                T------GDSIDINAVLPNSNAQKYVQAYYTAAPRPTPDSLPVQDAGDGS
MUL_3698|M.ulcerans_Agy99           T------GHELDLEAVLSASPAQTYLQAYYTAPFSSSSESMRFNNAGDGS
MSMEG_3578|M.smegmatis_MC2_155      DAADNLDGNEVDVEALLPSSNPQKYLQALYTAPFTDWDKAIENDDAGDGS
TH_2298|M.thermoresistible__bu      -------GSRLRVEALLPSGSAQRYLQAHYTAPFSDWDAAIDNDDAGDGS
MAB_0490c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02341|M.leprae_Br4923          EKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTAVGVQVGM
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2435c|M.tuberculosis_H37Rv        AWSAANAQFNSYFREIVTRFDYDDAVLLDTRGNIVYTLSKDPDLGTNILT
Mb2461c|M.bovis_AF2122/97           AWSAANAQFNSYFREIVTRFDYDDAVLLDTRGNIVYTLSKDPDLGTNILT
MMAR_3757|M.marinum_M               AWSAANAEFNGYFREIVTRFDYDDAVLLDTRGNIVYSLSKDPDLGTNILT
MAV_1745|M.avium_104                AWSAANARFDFYVRDIATRFDYRDALLLDTQGNVVYSVMKGPDLGTNILT
MUL_3698|M.ulcerans_Agy99           AWSAANARFNDFFRGIVTRFQYRDALLLDLQGNVVYSVNEGPDLGTNLFT
MSMEG_3578|M.smegmatis_MC2_155      GWSAANALFNGFFREIVTRSGFDDALLLDTRGNVVYTAYKGSDLGTNIYT
TH_2298|M.thermoresistible__bu      AWSAANARFHDFFREIVERFEFEDALLIDTRGNVVYSAYKGVDLGTNLHT
MAB_0490c|M.abscessus_ATCC_199      ---MTGAEGRPDRRPLARAARYSRWVMRTPWPLFIMGIAQSNLVGALFVL
MLBr_02341|M.leprae_Br4923          AQRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLL
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       -------------------------------------------MRPVCVP
Rv2435c|M.tuberculosis_H37Rv        GPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVPTAWLVAPVEAG
Mb2461c|M.bovis_AF2122/97           GPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVPTAWLVAPVEAG
MMAR_3757|M.marinum_M               GPYRESNLRDAYLRALGANAVDFTWITDFEPYQPQLDAATAWLVSPVLQG
MAV_1745|M.avium_104                GPYRESKLREAYQKALASNDVDFVWITDFQPYQPQLDAPTAWVVSPVGMN
MUL_3698|M.ulcerans_Agy99           GPYRETNLRTAYQKALASNEIDFVWITDFQRYQPEVDAPTAWLVSPVGVD
MSMEG_3578|M.smegmatis_MC2_155      GPYKGGELSEAYREALNSNTVDYVAVTDFGIYQPSG-TPTAWMVSPIGGG
TH_2298|M.thermoresistible__bu      GPYRETALSEAYRKALGSNMVDHVGLTDFSTYQPTS-EPTAWMVSPVGTG
MAB_0490c|M.abscessus_ATCC_199      GFLRFG--------LPPSDRVELTELGPTRLIILGFSLFILFVVGAIVST
MLBr_02341|M.leprae_Br4923          RVAEPRQPTWFSESTLVGREWELATLAAMLDRSIGGRGSVVGLVGPAGIG
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          ------------------MGRRQSVLMIAGWIAAAVSAAFGAFQLTLGGS
Mvan_2839|M.vanbaalenii_PYR-1       EVTLGRRAWSPSRHRHERVARRQRVLMIASWIAAAASVGFGVFQLTFGGP
Rv2435c|M.tuberculosis_H37Rv        GKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDS
Mb2461c|M.bovis_AF2122/97           GKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDS
MMAR_3757|M.marinum_M               GRTEGVLALPLPIAKINKMMTADKNWQAAGMGTGTETYLAGPDNLMRSDS
MAV_1745|M.avium_104                GRIEGVMALPVPAAKINKIMTAGGHWEAAGMGPATETYLAGPDDLMRSDS
MUL_3698|M.ulcerans_Agy99           GKLQGVMALALPPTNLNQIMNANEKWEAVGMGRSTETYLAGSDNLMRSDS
MSMEG_3578|M.smegmatis_MC2_155      GRIEGVLALQFPISVVNQLMTMDGKWEESGLGETGETYLVGPDGLMRSDS
TH_2298|M.thermoresistible__bu      GRILGALALQFPIDKINRVMTADRQWESVGLGRTGETYLVGTDDLMRSDS
MAB_0490c|M.abscessus_ATCC_199      YLLLPVLRWQYRSPDFESEGSEAVRVRALQMPFYRTVISVAT-WLVGGAI
MLBr_02341|M.leprae_Br4923          KTRLVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISGLD
                                                                                   .  

Mflv_3576|M.gilvum_PYR-GCK          LWWLGAVN------VLCALVFLWIPRLCPLG--ELLAPLTFVTFAYMSVT
Mvan_2839|M.vanbaalenii_PYR-1       LWWLGAVN------IGCGVVFLAIPRLCPLG--ELIAPLTFVVFAYTSVG
Rv2435c|M.tuberculosis_H37Rv        RLFLQDPEEYRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRG
Mb2461c|M.bovis_AF2122/97           RLFLQDPEEYRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRG
MMAR_3757|M.marinum_M               RLFLQDPEEYRRQAVAAGTSPEVVNRAIQLGSTVLLQPVATAGLREAQRG
MAV_1745|M.avium_104                RVFVEDPQQYRRDAIDAGTPPDVVDRAIHLGGTTLVQPVATAGLRAAQRG
MUL_3698|M.ulcerans_Agy99           RLFLESPDEYRREALAGGTREDVVNKAMWLGTTVLVQPVPSAGLRAALRG
MSMEG_3578|M.smegmatis_MC2_155      RLFLENPEQFKADVIEAGTPPGVAEQSILHGGTTLVQPVSDEASKLAGQG
TH_2298|M.thermoresistible__bu      RLFLEDPEQFKRAVVEAGTPPTVAEESLRSGGTTLVQPIRNEAVDRAQRG
MAB_0490c|M.abscessus_ATCC_199      FVAVTWSSTHSSVLVAAFATVLGATTTSIIGYLQSERVLRPVAIQALRRG
MLBr_02341|M.leprae_Br4923          DRSARARVREQIPDADTQDLLLLDDLLGIADPAVELPRLDPDARRRRLTA
                                                                  .       :           

Mflv_3576|M.gilvum_PYR-GCK          FF----CYTIGTGSG-----------------MQFYFLVAASLVLLVLGI
Mvan_2839|M.vanbaalenii_PYR-1       FI----CYTIGTGSG-----------------LQFYFLVAASLVVLVLGI
Rv2435c|M.tuberculosis_H37Rv        QT----GTVTSTDYTGSRELEAYAPLNVPDSDLHWSILATRNDSEAFAAV
Mb2461c|M.bovis_AF2122/97           QT----GTVTSTDYTGSRELEAYAPLNVPDSDLHWSILATRNDSEAFAAV
MMAR_3757|M.marinum_M               QT----GTVSAVDYTGNRELEAFAPLNIPNSDLHWSILATNDDSAAFAAA
MAV_1745|M.avium_104                ET----GVVTATDYMGNRELEAYAPLNIPNSDLHWSILATRDNSDAFARL
MUL_3698|M.ulcerans_Agy99           QS----GITKDTDYLGNRELEAYAPLDVPNSDLRWAILATRDDWDAYERL
MSMEG_3578|M.smegmatis_MC2_155      QS----GSIIERDYLGQETLQAYAPLDLTG--LDWSVVAKIDTAEAFAPV
TH_2298|M.thermoresistible__bu      QT----GTLIGTDYLGREALQSYAPVDLPG--LNWSIVAEKDTAEAFGPV
MAB_0490c|M.abscessus_ATCC_199      VP----ENVTAPGVIVRQILTWALSTGVPILAIVLTVVGQRAG-YLKSNA
MLBr_02341|M.leprae_Br4923          LINVAQLALSRPAVFVVEDVHWIDEVSDSMLADFLAVIPQTRSMALVTYR
                                                                        .:            

Mflv_3576|M.gilvum_PYR-GCK          ERVALAAVIAGVGVVITVVLELTVPEDRGLGPSWTLTAG-----------
Mvan_2839|M.vanbaalenii_PYR-1       ERIALAAAIAAAGVIITIVLELTVPDDRGLGPSWTLTAG-----------
Rv2435c|M.tuberculosis_H37Rv        ASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQKI-------
Mb2461c|M.bovis_AF2122/97           ASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQKI-------
MMAR_3757|M.marinum_M               AAFSKALVLVTVAMIVIICVFSMLIAQLMVRPIRRLEAGTEKI-------
MAV_1745|M.avium_104                GRFSKNLVIAVTAMIFVICVASMFVAQAAVRPVRRLEEGTRKI-------
MUL_3698|M.ulcerans_Agy99           SSFGRTVVLAVAGITLFICVVSMVLAKLLVRPIRRLEAGTEKI-------
MSMEG_3578|M.smegmatis_MC2_155      TKFTRTLVLSTVAMIFAVCIAAILLARVFVRPIRRLEAGAQQI-------
TH_2298|M.thermoresistible__bu      VEFTRTLVLSTVSIVFAVCLAAMLLARIFVRPVRRLEAGVRRV-------
MAB_0490c|M.abscessus_ATCC_199      DNLTGSILILAIIALAIGLMGTLLVATSIADPLRQLRWALSEV-------
MLBr_02341|M.leprae_Br4923          PEYHGALRHVVGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITER
                                                           .           *  .           

Mflv_3576|M.gilvum_PYR-GCK          -----FISAVTSSAVMIVATIWYTLREIER----AESAMENEYERSERLL
Mvan_2839|M.vanbaalenii_PYR-1       -----FISAVVSSVVIIVATIWYTLREIDR----AEAAMAAEYERSEELL
Rv2435c|M.tuberculosis_H37Rv        -SAGDYEVNIPVKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLL
Mb2461c|M.bovis_AF2122/97           -SAGDYEVNIPVKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLL
MMAR_3757|M.marinum_M               -SGGDYDVAIPVKSRDEIGDLTAAFNEMSRSLNIKEDLLNEQRRENDRLL
MAV_1745|M.avium_104                -SSGDYDINIPVRARDEIGDLTAAFNEMSRNLAIKEELLNEQRRENDRLL
MUL_3698|M.ulcerans_Agy99           -RSGDYEVTVPVKSRDELGDLTAAFNEMSSNLKVKDQLLTEQRSQNEQLL
MSMEG_3578|M.smegmatis_MC2_155      -SAGDYGVALPVVSRDEFGDLTVAFNEMSRNLRIKEDLLDEQRKENDRLL
TH_2298|M.thermoresistible__bu      -ATGDYHVRLPVTSHDEFGDLTAAFNDMSRNLATKEELLAEQRRENDRLL
MAB_0490c|M.abscessus_ATCC_199      -QRGNYNAHVPIYDASELGLLQAGFNDMVRDLG--------ERQRLRDLF
MLBr_02341|M.leprae_Br4923          AAGNPFFAQEITRELAERGVLTGERGRYACSTDVAEVCVPATLQATIAAR
                                         :            . :                             

Mflv_3576|M.gilvum_PYR-GCK          ANILPATIAERLKEPTRTVIADKYDDASILFADIAGYTKRASDTAPAE--
Mvan_2839|M.vanbaalenii_PYR-1       ANILPATIADRLKEPTRTVIADKYDDASILFADIAGYTKRASETPPSE--
Rv2435c|M.tuberculosis_H37Rv        LSMMPEPVVERYRL-GEQTIAQEHQDVTVLFADILGVDEISSGLSGNE--
Mb2461c|M.bovis_AF2122/97           LSMMPEPVVERYRL-GEQTIAQEHQDVTVLFADILGVDEISSGLSGNE--
MMAR_3757|M.marinum_M               LSMMPEPVVQRYRE-GEQTIAQEHQDVTVIFADILGLDEVSRSLSGNE--
MAV_1745|M.avium_104                LALMPESVLQRYRE-GEETIAQKHQDVAIIYADIVGLDELFTEMPEAQ--
MUL_3698|M.ulcerans_Agy99           LALMPEPVVQRYRA-DGEVIAEEHQDVTVIFAELIGLEEISDGLSGDE--
MSMEG_3578|M.smegmatis_MC2_155      LSLMPEPVVQRYRE-GEETIAQDHQNVTVLFADLMGLDRLSASMSSDE--
TH_2298|M.thermoresistible__bu      LSLMPEPVVQRYRD-GEQTIAQDHQDVTVIFADIVGLDEVSFNLPSAE--
MAB_0490c|M.abscessus_ATCC_199      GRYVGEDVARRALEYGTELGGQE-RSVAVLFVDLVGSTQLASTRGPAV--
MLBr_02341|M.leprae_Br4923          IDRLSPPAKQLLVAAAVIGFRFGSDLLASLGIDLSVDELIDANLVDQVRF
                                       :                       : :  ::                

Mflv_3576|M.gilvum_PYR-GCK          LVRFLDLLYTDLDALVDRHGLEKVKTSGDSYMVVSGVPTPRPDHLEALAT
Mvan_2839|M.vanbaalenii_PYR-1       LVRFLDRLYTDLDALVDRHGLEKVKTSGDSYMVVSGVPNPRADHLEALAL
Rv2435c|M.tuberculosis_H37Rv        LVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPRTVD
Mb2461c|M.bovis_AF2122/97           LVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPRTVD
MMAR_3757|M.marinum_M               LIAIVDDLFRQFDSAAESLGVERIRTLHNGYLASCGVTTPRLDNVARTVA
MAV_1745|M.avium_104                LVGTVDELFRQFDSAAETLGVERIRTFHNGYLASCGVVTPRLDSIHRAVD
MUL_3698|M.ulcerans_Agy99           LVGIVDELFRQFDSAAQSLGVEPIRTFHNGYLAACGATTPRLDNVHRGIE
MSMEG_3578|M.smegmatis_MC2_155      HLSIVNKLVRQFDAAAESLGVERVRTLHNGYLASCGLTVPRLDNVRRTVD
TH_2298|M.thermoresistible__bu      AVPIVNELIRQFDAAADHHGVERVRTMHNGYIASCGLSVPRLDNVRRTVD
MAB_0490c|M.abscessus_ATCC_199      VVRVLNEFFRVIVDTVNKHGGFVNKFQGDAALAIFGAPIDHPDGAAAALA
MLBr_02341|M.leprae_Br4923          TAPVEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEARAPHSVDQHAV
                                           :   :   .   .               .      .       

Mflv_3576|M.gilvum_PYR-GCK          LALDMSEAVADLKDPRGRDVPLRIGMAMGPVVAGVVGAKK--------FF
Mvan_2839|M.vanbaalenii_PYR-1       LALDMADAVADLKDPQGHDVPLRIGMASGPVVAGVVGAKK--------FF
Rv2435c|M.tuberculosis_H37Rv        FALEMRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSS--------VV
Mb2461c|M.bovis_AF2122/97           FALEMRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSS--------VV
MMAR_3757|M.marinum_M               FALEMQRIIERFNHQSGHQLRLRAGINTGNVISGLVGRTS--------VV
MAV_1745|M.avium_104                FALEIGRIIDRFNSQTGHQLGLRIGVNTGNVVSGLVGRSG--------LV
MUL_3698|M.ulcerans_Agy99           FALEIELIVNRFANQSQHPLRVRVGVTTGRVVSGRVGRSN--------LA
MSMEG_3578|M.smegmatis_MC2_155      FAFEMQRIVDRFRGETGYDLRLRAGIDTGTVSSGLVGRSS--------LA
TH_2298|M.thermoresistible__bu      FALDLQRIIDRFTRETGHRLELRAGIDTGTVKSGLVDRSR--------LA
MAB_0490c|M.abscessus_ATCC_199      AARELSGELTNVLGSND----FGIGVSAGRAIAGHIGAQAR-------FE
MLBr_02341|M.leprae_Br4923          LIAEHLEAAGDLHAAYGWHMRAAAWATNQDVRAARVSWEHATKIADALTA
                                       :       .                  . :. :.             

Mflv_3576|M.gilvum_PYR-GCK          YDVWGDAVNVASRMETTDEE--GRIQVPDNVYQRLRH--AFVLEERGLID
Mvan_2839|M.vanbaalenii_PYR-1       YDVWGDAVNVASRMETTDVE--GRIQVPDNVYERLRD--RFVLEERGVVD
Rv2435c|M.tuberculosis_H37Rv        YDMWGAAVSLAYQMHSGSPQ--PGIYVTSQVYEAMRD--VWQFTAAGTIS
Mb2461c|M.bovis_AF2122/97           YDMWGAAVSLAYQMHSGSPQ--PGIYVTSQVYEAMRD--VWQFTAAGTIS
MMAR_3757|M.marinum_M               YDMWGAAVSTAYQMHSGSPQ--PGIYVTSQVYEAMRD--ERQFAPAGTIA
MAV_1745|M.avium_104                YDMWGGAVSLAYQMHSGSPQ--PGIYVSSQVYEAMRD--VRQFAPAGTIS
MUL_3698|M.ulcerans_Agy99           YDMWGGAVQMAYRMLGHLSD--PGIYVSARVHDAMRE--IWTFTPAGAIS
MSMEG_3578|M.smegmatis_MC2_155      YDMWGAAVDLAYQVQRGMPQ--PGVYVTDQVHDAVRD--IRQFTAVGSVT
TH_2298|M.thermoresistible__bu      YDMWGSAVNIAYQVQTGTAK--PGIFVTTRVRDVLRD--TYRFEQAGQID
MAB_0490c|M.abscessus_ATCC_199      YTVIGDPVNEAARLTELAKNEPGNVLASASAVMEARDEEALRWDVGETVE
MLBr_02341|M.leprae_Br4923          EDPHRAAMCIAPRTRLCGIAWRGRFNSSSGFDEVRQLCNATGDKAPLAVA
                                          .:  * :           .  .       :            : 

Mflv_3576|M.gilvum_PYR-GCK          VKGKGPMHTWYLVGHRARAVTPSSSPP
Mvan_2839|M.vanbaalenii_PYR-1       VKGKGPMHTWYLVAHRAEAVTPSGSPT
Rv2435c|M.tuberculosis_H37Rv        VGGL-EEPIYRLSERS-----------
Mb2461c|M.bovis_AF2122/97           VGGL-EEPIYRLSERS-----------
MMAR_3757|M.marinum_M               VGGA-EQQIYRMSEQS-----------
MAV_1745|M.avium_104                VGGT-DQAIYRLLER------------
MUL_3698|M.ulcerans_Agy99           VRGS-QQQIWQVSERR-----------
MSMEG_3578|M.smegmatis_MC2_155      VDGT-ERPIWRLSERQS----------
TH_2298|M.thermoresistible__bu      IDGA-AEPVWRLTEQRS----------
MAB_0490c|M.abscessus_ATCC_199      LRGRTVSTQVARPRHG-----------
MLBr_02341|M.leprae_Br4923          TVGPAIDHVYQDRLH------------
                                      *           :