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MDAEAFVGFRQVPAARYGGLMATTAALPRRIHAFVRWVVRTPWPLFSLSMLQSDIIGALFVLGFLRYGLP PQDNIQLQDLPPVNLLIFVSTVIILFLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPL YRTLISLAVWATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVLRPVAVAALRSGVPEN VNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIALLHATPEALFNPILMMALAALGIGSVSTLLVAMSI ADPLRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVARRALER GTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVVVETVARHGGFVNKFQGDAALAIFGAP IEHPDGAGAALSAARELHDELIPVLGSAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAK LEDGHVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVSSEVRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3645 | - | - | 100% (549) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv1318c | - | 1e-89 | 41.43% (449) | adenylate cyclase |
| M. tuberculosis H37Rv | Rv1320c | - | 5e-82 | 37.48% (507) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3669 | - | 0.0 | 100.00% (549) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1395 | - | 0.0 | 76.28% (527) | putative adenylate/guanylate cyclase |
| M. leprae Br4923 | MLBr_00201 | - | 0.0 | 85.28% (530) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_0490c | - | 0.0 | 69.31% (505) | putative adenylate cyclase |
| M. marinum M | MMAR_5137 | - | 0.0 | 85.93% (526) | adenylate cyclase |
| M. avium 104 | MAV_0518 | - | 0.0 | 84.64% (534) | adenylate cyclase, family protein 3 |
| M. smegmatis MC2 155 | MSMEG_6154 | - | 0.0 | 77.32% (529) | adenylate cyclase, family protein 3 |
| M. thermoresistible (build 8) | TH_0858 | - | 0.0 | 79.35% (494) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_4221 | - | 0.0 | 85.55% (526) | adenylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_5395 | - | 0.0 | 78.38% (518) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1395|M.gilvum_PYR-GCK --------------------MAADPT-----ETGRISAFVRWVARTPWPV
Mvan_5395|M.vanbaalenii_PYR-1 --------------------MAAEPI-----EVGRISAFVRWVARTPWPV
MSMEG_6154|M.smegmatis_MC2_155 --------------------MTTEPI-----PIARIGAFARWVARTPWPV
TH_0858|M.thermoresistible__bu -------------------------------------------------V
Rv3645|M.tuberculosis_H37Rv MDAEAFVGFRQVPAARYGGLMATTAA-----LPRRIHAFVRWVVRTPWPL
Mb3669|M.bovis_AF2122/97 MDAEAFVGFRQVPAARYGGLMATTAA-----LPRRIHAFVRWVVRTPWPL
MMAR_5137|M.marinum_M --------------------MATVAT-----LPGRINGFARWVVRTPWPV
MUL_4221|M.ulcerans_Agy99 --------------------MATVAT-----LPGRINGFARWVVRTPWPV
MLBr_00201|M.leprae_Br4923 --------------------MATQAAG----LPGRIGAFVRWGIRTPWPL
MAV_0518|M.avium_104 --------------------MTTAAA-----LPGRISAFARWVVRTPWPL
MAB_0490c|M.abscessus_ATCC_199 --------------------MTGAEGRPDRRPLARAARYSRWVMRTPWPL
:
Mflv_1395|M.gilvum_PYR-GCK FTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGYLFVS
Mvan_5395|M.vanbaalenii_PYR-1 FTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGYLFIS
MSMEG_6154|M.smegmatis_MC2_155 FTLGMLQADIIGALFVLGFLRFGLPPEDRIQLQDLPAFNLAIFLAYLFVS
TH_0858|M.thermoresistible__bu FALGMVQADIIGALFVLGFLRFGLPPGDRLELQDLPAFNLALFLGYLVVS
Rv3645|M.tuberculosis_H37Rv FSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIIL
Mb3669|M.bovis_AF2122/97 FSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIIL
MMAR_5137|M.marinum_M FSLSMLQADIIGGLFVLGFLRYGLPPNDRIQLQDLPPLNLAIFLTSVITL
MUL_4221|M.ulcerans_Agy99 FSLSMLQADIIGGLFVLGFLRYGLPPNDRIQLQDLPPLNLAIFLTSVITL
MLBr_00201|M.leprae_Br4923 FSLSMLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLAISTLSVVVA
MAV_0518|M.avium_104 FWLSMMQADIIGALFVLGFLRYALPPEDRIQLQDLPVVNLAVFATSLVVL
MAB_0490c|M.abscessus_ATCC_199 FIMGIAQSNLVGALFVLGFLRFGLPPSDRVELTELGPTRLIILGFSLFIL
* :.: *::::*.*:******:.*** *.::* :* .* : :.
Mflv_1395|M.gilvum_PYR-GCK FTVASYLTLRMLIPVMRWQRRDMLLGDRDPSDTEVARMRALKMPFYRSLI
Mvan_5395|M.vanbaalenii_PYR-1 FTVASYVTLRMLIPVMRWQRREMLLGDRDPAETEVARMRALKMPFYRSLI
MSMEG_6154|M.smegmatis_MC2_155 FTVGAYLALRLLIPVIRWQRRETVLSEGDPGITELARARALKMPFYRTLI
TH_0858|M.thermoresistible__bu FTVGAYVTLRLLLPVIRWQRRDTLLADPDPAATELARARALRMPFYRTLI
Rv3645|M.tuberculosis_H37Rv FLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLI
Mb3669|M.bovis_AF2122/97 FLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLI
MMAR_5137|M.marinum_M FLAGFALNLKLLVPVFRWQRRDNLVAAADPSATELARSRVLRMPFYRTLI
MUL_4221|M.ulcerans_Agy99 FLAGFALNLKLLVPVFRWQRRDNLVAAADPSATELARSRVLRMPFYRTLI
MLBr_00201|M.leprae_Br4923 FSTGFAVNLKLLMPVFRWQRRDNRLAEADPAATELARSRALRMPFYHTII
MAV_0518|M.avium_104 FLAASVVNLTLLMPVFRWQRRDNLLAESDPAATELARIRALRMPFYRTVT
MAB_0490c|M.abscessus_ATCC_199 FVVGAIVSTYLLLPVLRWQYRS---PDFESEGSEAVRVRALQMPFYRTVI
* .. : :*:**:*** *. :. :* .* *.*:**:*:::
Mflv_1395|M.gilvum_PYR-GCK SATNWLLGSVVFIVASWPVASKSAPVVAVATGLGATATAIIGYLQSERVL
Mvan_5395|M.vanbaalenii_PYR-1 SATNWLLGSVVFIVASWPVASKSAPVVAVATALGATATAIIGYLQSERVL
MSMEG_6154|M.smegmatis_MC2_155 SVTNWCLGSIVFIVASWPVASHSAPVVAVATALGATATAIIGYLQSERVL
TH_0858|M.thermoresistible__bu SGTNWFLGTIVFIVASWPVAGHSAPVIAVATGLGATATAIIGYLQAERVL
Rv3645|M.tuberculosis_H37Rv SLAVWATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVL
Mb3669|M.bovis_AF2122/97 SLAVWATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVL
MMAR_5137|M.marinum_M SVGSWAIGSVIFIVASWSVARYAAPVVAIATALGAIATAIIGYLQSERVL
MUL_4221|M.ulcerans_Agy99 SVGSWAIGSVIFIVASWSVARYAAPVVAIATALGAIATAIIGYLQSERVL
MLBr_00201|M.leprae_Br4923 SLVTWGIGGAVFIIASWSAARHSAPIVALATALGATATAIIGYLQSERVL
MAV_0518|M.avium_104 SMVIWCIGGVVFIIASWSVARFAAPVVAVATGLGAAATAIIGYLQCERVL
MAB_0490c|M.abscessus_ATCC_199 SVATWLVGGAIFVAVTWSSTHSSVLVAAFATVLGATTTSIIGYLQSERVL
* * * :*: .:*. : :. : *.** *** :*:******.****
Mflv_1395|M.gilvum_PYR-GCK RPVAVAALRGGVPENFRAPGVILRQVLTWVLSTGVPVLAIVLALVASKFE
Mvan_5395|M.vanbaalenii_PYR-1 RPVAVAALRGGVPENFRAPGVILRQVLSWVLSTGVPVLAILLALIASKLE
MSMEG_6154|M.smegmatis_MC2_155 RPVAVAALRGGVPENFRAPGVILRQVLTWVLSTGVPLLAIILALVASKFS
TH_0858|M.thermoresistible__bu RPVAVAALRGGVPENFRAPGVVLRQVLTWVLSTGVPVLAIVLALVASKVG
Rv3645|M.tuberculosis_H37Rv RPVAVAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIA
Mb3669|M.bovis_AF2122/97 RPVAVAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIA
MMAR_5137|M.marinum_M RPVAVAALRSGVPENLRSPGVILRLMLAWVLSTAVPLLAIVLAVVADKMA
MUL_4221|M.ulcerans_Agy99 RPVAVAALRSGVPENLRSPGVISRLMLAWVLSTAVPLLAIVLAVVADKMA
MLBr_00201|M.leprae_Br4923 RPVAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVLAIVLAVVADKIA
MAV_0518|M.avium_104 RPVAVAALRSGVPENVKAPGVILRQILTWMLSTAVPVLAIVLAVVADKTS
MAB_0490c|M.abscessus_ATCC_199 RPVAIQALRRGVPENVTAPGVIVRQILTWALSTGVPILAIVLTVVGQRAG
****: *** *****. :*** * :*:* **.**:***:*:: ..:
Mflv_1395|M.gilvum_PYR-GCK VLTAPADRLITTILLLAIVALIIGLSSTVLVAMSIADPLRQLRWALGEVQ
Mvan_5395|M.vanbaalenii_PYR-1 VLTAPADRLITTILLLSIVALVIGLSSTVLVAMSIADPLRQLRWALGEVQ
MSMEG_6154|M.smegmatis_MC2_155 ILTASADRLNTPILLLAVAALVIGMSSTVLVAMSIADPLRQLRWALGEVQ
TH_0858|M.thermoresistible__bu ILTAPAEQLTTPLLVLAIATLVIGLSGTVLVAMSIADPLRQLRWALGEVQ
Rv3645|M.tuberculosis_H37Rv LLHATPEALFNPILMMALAALGIGSVSTLLVAMSIADPLRQLRWALSEVQ
Mb3669|M.bovis_AF2122/97 LLHATPEALFNPILMMALAALGIGSVSTLLVAMSIADPLRQLRWALSEVQ
MMAR_5137|M.marinum_M ILHATPDKLFNPILLLALAALAIGSASTLLVSMSIADPLRQLRWALSEVQ
MUL_4221|M.ulcerans_Agy99 ILHATPDKLFNPILLLALAALAIGSASTLLVSMSIADPLRQLRWALSEVQ
MLBr_00201|M.leprae_Br4923 LLHAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIADPLRQLRWALSEVQ
MAV_0518|M.avium_104 LLHATPEKLFTPILLLAVAALGIGLVSTLLVAMSIADPLRQLRWALSEVQ
MAB_0490c|M.abscessus_ATCC_199 YLKSNADNLTGSILILAIIALAIGLMGTLLVATSIADPLRQLRWALSEVQ
* : .: * .:*:::: .* :* .* **: *************.***
Mflv_1395|M.gilvum_PYR-GCK RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
Mvan_5395|M.vanbaalenii_PYR-1 RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
MSMEG_6154|M.smegmatis_MC2_155 RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
TH_0858|M.thermoresistible__bu RGNFNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
Rv3645|M.tuberculosis_H37Rv RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
Mb3669|M.bovis_AF2122/97 RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
MMAR_5137|M.marinum_M RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MUL_4221|M.ulcerans_Agy99 RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MLBr_00201|M.leprae_Br4923 RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
MAV_0518|M.avium_104 RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MAB_0490c|M.abscessus_ATCC_199 RGNYNAHVPIYDASELGLLQAGFNDMVRDLGERQRLRDLFGRYVGEDVAR
***:***: *******************:*.*******************
Mflv_1395|M.gilvum_PYR-GCK RALERGTELGGQERDVAVLFVDLVGSTHLAATIPASEVVSLLNEFFRVVV
Mvan_5395|M.vanbaalenii_PYR-1 RALERGTELGGQERDVAVLFVDLVGSTHLAATRPAAEVVNLLNEFFRVVV
MSMEG_6154|M.smegmatis_MC2_155 RALERGTELGGQERDVAVLFVDLVGSTHLASTIPAADVVNLLNEFFRVIV
TH_0858|M.thermoresistible__bu RALERGTELGGQERDVAVLFVDLVGSTRLAATTPPADVVNLLNEFFRVVV
Rv3645|M.tuberculosis_H37Rv RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVVV
Mb3669|M.bovis_AF2122/97 RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVVV
MMAR_5137|M.marinum_M RAIERGTELGGQERDVAVLFVDLVGSTQLAATRPPVEVVGLLNEFFRVVV
MUL_4221|M.ulcerans_Agy99 RAIERGTELGGQERDVAVLFVDLVGSTQLAATRPPVEVVGLLNEFFRVVV
MLBr_00201|M.leprae_Br4923 RALEHGTELGGQERDVAVLFVDLIGSTQLAETKPPTKVVHLLNEFFRVVV
MAV_0518|M.avium_104 RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVHLLNEFFRVVV
MAB_0490c|M.abscessus_ATCC_199 RALEYGTELGGQERSVAVLFVDLVGSTQLASTRGPAVVVRVLNEFFRVIV
**:* *********.********:***:** * . ** :*******:*
Mflv_1395|M.gilvum_PYR-GCK DTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDELINVL
Mvan_5395|M.vanbaalenii_PYR-1 DTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDELIRVL
MSMEG_6154|M.smegmatis_MC2_155 DTVNKHGGFVNKFQGDAALAIFGAPIEHPDASGGALAASRELHDELIKVL
TH_0858|M.thermoresistible__bu DTVNRHGGFVNKFQGDAALAIFGAPIEHPDACGAALAAARELHDELIAVL
Rv3645|M.tuberculosis_H37Rv ETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPVL
Mb3669|M.bovis_AF2122/97 ETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPVL
MMAR_5137|M.marinum_M DTVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALRAARELHDELIPVL
MUL_4221|M.ulcerans_Agy99 DTVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALRAARELHDELIPVL
MLBr_00201|M.leprae_Br4923 DTVGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALSAARELHDELLPVL
MAV_0518|M.avium_104 ETVGKHGGFVNKFQGDAALAIFGAPIEHPDSPGGALAAARELHDALLPVI
MAB_0490c|M.abscessus_ATCC_199 DTVNKHGGFVNKFQGDAALAIFGAPIDHPDGAAAALAAARELSGELTNVL
:** :*********************:***. ..** *:*** . * *:
Mflv_1395|M.gilvum_PYR-GCK G-ETEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
Mvan_5395|M.vanbaalenii_PYR-1 G-ETDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
MSMEG_6154|M.smegmatis_MC2_155 GTETEFGIGVSAGRAIAGHIGAKARFEYTVIGDPVNEAARLTELAKLEEG
TH_0858|M.thermoresistible__bu G-ETEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
Rv3645|M.tuberculosis_H37Rv G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
Mb3669|M.bovis_AF2122/97 G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
MMAR_5137|M.marinum_M G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
MUL_4221|M.ulcerans_Agy99 G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
MLBr_00201|M.leprae_Br4923 G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
MAV_0518|M.avium_104 G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
MAB_0490c|M.abscessus_ATCC_199 G-SNDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKNEPG
* . :*****************:*********************** * *
Mflv_1395|M.gilvum_PYR-GCK HVLASSLAVADALDAEALCWNVGEVVELRGRTAPTQLARPVNLIRPPRVE
Mvan_5395|M.vanbaalenii_PYR-1 HVLASAIAVADALDAEALCWDVGEIVELRGRTAPTQLARPVNLVSPDDVS
MSMEG_6154|M.smegmatis_MC2_155 HVLASAIAVSGALDSEALCWDVGEIVELRGRTVPTQLARPINLARPEDLD
TH_0858|M.thermoresistible__bu HVLASAMAVSGALDAEALCWDVGETVELRGRTVPTQLARPVKLAFSNGPG
Rv3645|M.tuberculosis_H37Rv HVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVS
Mb3669|M.bovis_AF2122/97 HVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVS
MMAR_5137|M.marinum_M HVLASAIAISGALDAEALCWDVAEVVELRGRTAPTQLARPLNLAVAQQVS
MUL_4221|M.ulcerans_Agy99 HVLASAFAISGALDAEALCWDVAEVVELRGRTAPTQLARPLNLAVAQKVS
MLBr_00201|M.leprae_Br4923 HVLASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLARPLNLAVPEQIT
MAV_0518|M.avium_104 HVLASAIAVSGALDSEALCWDVGEVVELRGRTAPTQLARPVKLATPEEVA
MAB_0490c|M.abscessus_ATCC_199 NVLASASAVMEARDEEALRWDVGETVELRGRTVSTQVARPRHG-------
:****: *: * * *** *:*.* ******:..**:*** :
Mflv_1395|M.gilvum_PYR-GCK EK-VADDVPSTTR--------------------------
Mvan_5395|M.vanbaalenii_PYR-1 QE-VASDRR------------------------------
MSMEG_6154|M.smegmatis_MC2_155 GS-ANGQSTDGSPAETAFQQEKGLFAVEGVEVVGASVPG
TH_0858|M.thermoresistible__bu PS-NNSDAPGTRTTGSVSRADAETTAPES----------
Rv3645|M.tuberculosis_H37Rv -----SEVRG-----------------------------
Mb3669|M.bovis_AF2122/97 -----SEVRG-----------------------------
MMAR_5137|M.marinum_M -----TKSGS-----------------------------
MUL_4221|M.ulcerans_Agy99 -----TKSGS-----------------------------
MLBr_00201|M.leprae_Br4923 -----SEVTG-----------------------------
MAV_0518|M.avium_104 PQEVSSEVSG-----------------------------
MAB_0490c|M.abscessus_ATCC_199 ---------------------------------------