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VLSRISIQSKLLAMLLVTSVLSAAVVGFIGYQSGRSSLRDSVFDRLTEIRTAQARQLETQFRSFRNSLVI YTRGTTAIEAARAFTAGFDQLGDATISPAQQKAITDWYENQFSATTEHSDAADNLDGNEVDVEALLPSSN PQKYLQALYTAPFTDWDKAIENDDAGDGSGWSAANALFNGFFREIVTRSGFDDALLLDTRGNVVYTAYKG SDLGTNIYTGPYKGGELSEAYREALNSNTVDYVAVTDFGIYQPSGTPTAWMVSPIGGGGRIEGVLALQFP ISVVNQLMTMDGKWEESGLGETGETYLVGPDGLMRSDSRLFLENPEQFKADVIEAGTPPGVAEQSILHGG TTLVQPVSDEASKLAGQGQSGSIIERDYLGQETLQAYAPLDLTGLDWSVVAKIDTAEAFAPVTKFTRTLV LSTVAMIFAVCIAAILLARVFVRPIRRLEAGAQQISAGDYGVALPVVSRDEFGDLTVAFNEMSRNLRIKE DLLDEQRKENDRLLLSLMPEPVVQRYREGEETIAQDHQNVTVLFADLMGLDRLSASMSSDEHLSIVNKLV RQFDAAAESLGVERVRTLHNGYLASCGLTVPRLDNVRRTVDFAFEMQRIVDRFRGETGYDLRLRAGIDTG TVSSGLVGRSSLAYDMWGAAVDLAYQVQRGMPQPGVYVTDQVHDAVRDIRQFTAVGSVTVDGTERPIWRL SERQS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_3578 | - | - | 100% (705) | putative cyclase |
M. smegmatis MC2 155 | MSMEG_0228 | - | 2e-11 | 25.00% (176) | adenylate and guanylate cyclase catalytic domain-containing |
M. smegmatis MC2 155 | MSMEG_6154 | - | 1e-08 | 24.66% (146) | adenylate cyclase, family protein 3 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2461c | - | 0.0 | 59.89% (703) | putative cyclase (adenylyl-or guanylyl-)(adenylate-or |
M. gilvum PYR-GCK | Mflv_3576 | - | 1e-22 | 26.19% (210) | putative adenylate/guanylate cyclase |
M. tuberculosis H37Rv | Rv2435c | - | 0.0 | 59.89% (703) | cyclase |
M. leprae Br4923 | MLBr_02341 | - | 1e-10 | 26.59% (173) | putative regulatory protein |
M. abscessus ATCC 19977 | MAB_0490c | - | 3e-09 | 21.94% (237) | putative adenylate cyclase |
M. marinum M | MMAR_3757 | - | 0.0 | 58.46% (703) | adenylate or guanylate cyclase |
M. avium 104 | MAV_1745 | - | 0.0 | 54.05% (703) | adenylate and guanylate cyclase catalytic domain-containing |
M. thermoresistible (build 8) | TH_2298 | - | 0.0 | 67.38% (702) | PROBABLE CYCLASE (ADENYLYL-OR GUANYLYL-)(ADENYLATE-OR |
M. ulcerans Agy99 | MUL_3698 | - | 0.0 | 51.14% (704) | adenylate or guanylate cyclase |
M. vanbaalenii PYR-1 | Mvan_2839 | - | 8e-22 | 26.67% (210) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3578|M.smegmatis_MC2_155 -------------------------MLS------RISIQSKLLAMLLVTS TH_2298|M.thermoresistible__bu ---------------MAIRRKPRRHWTP------RFSIQSKLLMMLLTTS Mb2461c|M.bovis_AF2122/97 MTSGEALDSVAESESTPAKKRHKNVLRR--RPRFRASIQSKLMVLLLLTS Rv2435c|M.tuberculosis_H37Rv MTSGEALDSVAESESTPAKKRHKNVLRR--RPRFRASIQSKLMVLLLLTS MMAR_3757|M.marinum_M -----------MVEGAPAHDGAKGTRRR--RPRFRVSIQSKLMVLLLLSS MAV_1745|M.avium_104 MTTSELTDAESDIAPAPAPQPAKRTRRTPLRSRFRFGIQSKILITMLLSS MUL_3698|M.ulcerans_Agy99 ------------------------MLRF-----LRVGIPAKLLVTLLVCS MAB_0490c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 ---------------------------------MTTALVCVACGAELRSI Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3578|M.smegmatis_MC2_155 VLSAAVVGFIGYQSGRSSLRDSVFDRLTEIRTAQARQLETQFRSFRNSLV TH_2298|M.thermoresistible__bu VLAVAVVGFIGYQSGRSSLRASAFDGLIEIRTSQARELETLFSDLTNSLV Mb2461c|M.bovis_AF2122/97 IVSVAAIAAIVYQSGRTSLRAAAYERLTQLRESQKRAVETLFSDLTNSLV Rv2435c|M.tuberculosis_H37Rv IVSVAAIAAIVYQSGRTSLRAAAYERLTQLRESQKRAVETLFSDLTNSLV MMAR_3757|M.marinum_M IVSVAAIVAVGFHTGRSSLSAAAYGRLTQLRESQLRAVETLFSDLTNSLV MAV_1745|M.avium_104 ILGVAVIGLIGAVSGRNALRQVESERLIELREGQKRAVQALFREVTNSLI MUL_3698|M.ulcerans_Agy99 ILSVAVVGVIGYVSGRNALQRVAVERLHQLREAQKRQVEALFSELTKSVM MAB_0490c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 AKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLERLREIMT Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3578|M.smegmatis_MC2_155 IYTRGTTAIEAARAFTAGFDQLGDATISPAQQKAITDWYENQFSATTEHS TH_2298|M.thermoresistible__bu IYSRGDTAAAAVTAFTDAFDELHDATVTPAQHRAIVDYYERHFGGDTTAT Mb2461c|M.bovis_AF2122/97 IYERGLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEFITPVERT Rv2435c|M.tuberculosis_H37Rv IYERGLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEFITPVERT MMAR_3757|M.marinum_M IYARGLTVIDAVAQFTAGFDQLADATISPAQQESLVNYYNDQLIKPVEHL MAV_1745|M.avium_104 VWSGGFTINEATAALTTGFAQLANATITPAQQQQLVNYYDNQMLKPIKHA MUL_3698|M.ulcerans_Agy99 VYSNGMSANEATAALTDGFAQLANATVDPVQQQAIVDYYVNELIKPIDQA MAB_0490c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 ELVSRAAGVIERYGGTVDKFTGDGIMAIFGAPTALEDHALRACLAALGVQ Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3578|M.smegmatis_MC2_155 DAADNLDGNEVDVEALLPSSNPQKYLQALYTAPFTDWDKAIENDDAGDGS TH_2298|M.thermoresistible__bu -------GSRLRVEALLPSGSAQRYLQAHYTAPFSDWDAAIDNDDAGDGS Mb2461c|M.bovis_AF2122/97 T------GDKLDITALLPTSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGS Rv2435c|M.tuberculosis_H37Rv T------GDKLDITALLPTSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGS MMAR_3757|M.marinum_M T------GTKLDLEALLPTSPAQKYLQAYYTAPFTSDQDSMRLDDAGDGS MAV_1745|M.avium_104 T------GDSIDINAVLPNSNAQKYVQAYYTAAPRPTPDSLPVQDAGDGS MUL_3698|M.ulcerans_Agy99 T------GHELDLEAVLSASPAQTYLQAYYTAPFSSSSESMRFNNAGDGS MAB_0490c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 EKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTAVGVQVGM Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3578|M.smegmatis_MC2_155 GWSAANALFNGFFREIVTRSGFDDALLLDTRGNVVYTAYKGSDLGTNIYT TH_2298|M.thermoresistible__bu AWSAANARFHDFFREIVERFEFEDALLIDTRGNVVYSAYKGVDLGTNLHT Mb2461c|M.bovis_AF2122/97 AWSAANAQFNSYFREIVTRFDYDDAVLLDTRGNIVYTLSKDPDLGTNILT Rv2435c|M.tuberculosis_H37Rv AWSAANAQFNSYFREIVTRFDYDDAVLLDTRGNIVYTLSKDPDLGTNILT MMAR_3757|M.marinum_M AWSAANAEFNGYFREIVTRFDYDDAVLLDTRGNIVYSLSKDPDLGTNILT MAV_1745|M.avium_104 AWSAANARFDFYVRDIATRFDYRDALLLDTQGNVVYSVMKGPDLGTNILT MUL_3698|M.ulcerans_Agy99 AWSAANARFNDFFRGIVTRFQYRDALLLDLQGNVVYSVNEGPDLGTNLFT MAB_0490c|M.abscessus_ATCC_199 ---MTGAEGRPDRRPLARAARYSRWVMRTPWPLFIMGIAQSNLVGALFVL MLBr_02341|M.leprae_Br4923 AQRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLL Mflv_3576|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2839|M.vanbaalenii_PYR-1 -------------------------------------------MRPVCVP MSMEG_3578|M.smegmatis_MC2_155 GPYKGGELSEAYREALNSNTVDYVAVTDFGIYQPSG-TPTAWMVSPIGGG TH_2298|M.thermoresistible__bu GPYRETALSEAYRKALGSNMVDHVGLTDFSTYQPTS-EPTAWMVSPVGTG Mb2461c|M.bovis_AF2122/97 GPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVPTAWLVAPVEAG Rv2435c|M.tuberculosis_H37Rv GPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVPTAWLVAPVEAG MMAR_3757|M.marinum_M GPYRESNLRDAYLRALGANAVDFTWITDFEPYQPQLDAATAWLVSPVLQG MAV_1745|M.avium_104 GPYRESKLREAYQKALASNDVDFVWITDFQPYQPQLDAPTAWVVSPVGMN MUL_3698|M.ulcerans_Agy99 GPYRETNLRTAYQKALASNEIDFVWITDFQRYQPEVDAPTAWLVSPVGVD MAB_0490c|M.abscessus_ATCC_199 GFLRFG--------LPPSDRVELTELGPTRLIILGFSLFILFVVGAIVST MLBr_02341|M.leprae_Br4923 RVAEPRQPTWFSESTLVGREWELATLAAMLDRSIGGRGSVVGLVGPAGIG Mflv_3576|M.gilvum_PYR-GCK ------------------MGRRQSVLMIAGWIAAAVSAAFGAFQLTLGGS Mvan_2839|M.vanbaalenii_PYR-1 EVTLGRRAWSPSRHRHERVARRQRVLMIASWIAAAASVGFGVFQLTFGGP MSMEG_3578|M.smegmatis_MC2_155 GRIEGVLALQFPISVVNQLMTMDGKWEESGLGETGETYLVGPDGLMRSDS TH_2298|M.thermoresistible__bu GRILGALALQFPIDKINRVMTADRQWESVGLGRTGETYLVGTDDLMRSDS Mb2461c|M.bovis_AF2122/97 GKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDS Rv2435c|M.tuberculosis_H37Rv GKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDS MMAR_3757|M.marinum_M GRTEGVLALPLPIAKINKMMTADKNWQAAGMGTGTETYLAGPDNLMRSDS MAV_1745|M.avium_104 GRIEGVMALPVPAAKINKIMTAGGHWEAAGMGPATETYLAGPDDLMRSDS MUL_3698|M.ulcerans_Agy99 GKLQGVMALALPPTNLNQIMNANEKWEAVGMGRSTETYLAGSDNLMRSDS MAB_0490c|M.abscessus_ATCC_199 YLLLPVLRWQYRSPDFESEGSEAVRVRALQMPFYRTVISVAT-WLVGGAI MLBr_02341|M.leprae_Br4923 KTRLVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISGLD . Mflv_3576|M.gilvum_PYR-GCK LWWLGAVN------VLCALVFLWIPRLCPLG--ELLAPLTFVTFAYMSVT Mvan_2839|M.vanbaalenii_PYR-1 LWWLGAVN------IGCGVVFLAIPRLCPLG--ELIAPLTFVVFAYTSVG MSMEG_3578|M.smegmatis_MC2_155 RLFLENPEQFKADVIEAGTPPGVAEQSILHGGTTLVQPVSDEASKLAGQG TH_2298|M.thermoresistible__bu RLFLEDPEQFKRAVVEAGTPPTVAEESLRSGGTTLVQPIRNEAVDRAQRG Mb2461c|M.bovis_AF2122/97 RLFLQDPEEYRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRG Rv2435c|M.tuberculosis_H37Rv RLFLQDPEEYRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRG MMAR_3757|M.marinum_M RLFLQDPEEYRRQAVAAGTSPEVVNRAIQLGSTVLLQPVATAGLREAQRG MAV_1745|M.avium_104 RVFVEDPQQYRRDAIDAGTPPDVVDRAIHLGGTTLVQPVATAGLRAAQRG MUL_3698|M.ulcerans_Agy99 RLFLESPDEYRREALAGGTREDVVNKAMWLGTTVLVQPVPSAGLRAALRG MAB_0490c|M.abscessus_ATCC_199 FVAVTWSSTHSSVLVAAFATVLGATTTSIIGYLQSERVLRPVAIQALRRG MLBr_02341|M.leprae_Br4923 DRSARARVREQIPDADTQDLLLLDDLLGIADPAVELPRLDPDARRRRLTA . : Mflv_3576|M.gilvum_PYR-GCK FF----CYTIGTGSG-----------------MQFYFLVAASLVLLVLGI Mvan_2839|M.vanbaalenii_PYR-1 FI----CYTIGTGSG-----------------LQFYFLVAASLVVLVLGI MSMEG_3578|M.smegmatis_MC2_155 QS----GSIIERDYLGQETLQAYAPLDLTG--LDWSVVAKIDTAEAFAPV TH_2298|M.thermoresistible__bu QT----GTLIGTDYLGREALQSYAPVDLPG--LNWSIVAEKDTAEAFGPV Mb2461c|M.bovis_AF2122/97 QT----GTVTSTDYTGSRELEAYAPLNVPDSDLHWSILATRNDSEAFAAV Rv2435c|M.tuberculosis_H37Rv QT----GTVTSTDYTGSRELEAYAPLNVPDSDLHWSILATRNDSEAFAAV MMAR_3757|M.marinum_M QT----GTVSAVDYTGNRELEAFAPLNIPNSDLHWSILATNDDSAAFAAA MAV_1745|M.avium_104 ET----GVVTATDYMGNRELEAYAPLNIPNSDLHWSILATRDNSDAFARL MUL_3698|M.ulcerans_Agy99 QS----GITKDTDYLGNRELEAYAPLDVPNSDLRWAILATRDDWDAYERL MAB_0490c|M.abscessus_ATCC_199 VP----ENVTAPGVIVRQILTWALSTGVPILAIVLTVVGQRAG-YLKSNA MLBr_02341|M.leprae_Br4923 LINVAQLALSRPAVFVVEDVHWIDEVSDSMLADFLAVIPQTRSMALVTYR .: Mflv_3576|M.gilvum_PYR-GCK ERVALAAVIAGVGVVITVVLELTVPEDRGLGPSWTLTAG----------- Mvan_2839|M.vanbaalenii_PYR-1 ERIALAAAIAAAGVIITIVLELTVPDDRGLGPSWTLTAG----------- MSMEG_3578|M.smegmatis_MC2_155 TKFTRTLVLSTVAMIFAVCIAAILLARVFVRPIRRLEAGAQQI------- TH_2298|M.thermoresistible__bu VEFTRTLVLSTVSIVFAVCLAAMLLARIFVRPVRRLEAGVRRV------- Mb2461c|M.bovis_AF2122/97 ASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQKI------- Rv2435c|M.tuberculosis_H37Rv ASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQKI------- MMAR_3757|M.marinum_M AAFSKALVLVTVAMIVIICVFSMLIAQLMVRPIRRLEAGTEKI------- MAV_1745|M.avium_104 GRFSKNLVIAVTAMIFVICVASMFVAQAAVRPVRRLEEGTRKI------- MUL_3698|M.ulcerans_Agy99 SSFGRTVVLAVAGITLFICVVSMVLAKLLVRPIRRLEAGTEKI------- MAB_0490c|M.abscessus_ATCC_199 DNLTGSILILAIIALAIGLMGTLLVATSIADPLRQLRWALSEV------- MLBr_02341|M.leprae_Br4923 PEYHGALRHVVGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITER . * . Mflv_3576|M.gilvum_PYR-GCK -----FISAVTSSAVMIVATIWYTLREIER----AESAMENEYERSERLL Mvan_2839|M.vanbaalenii_PYR-1 -----FISAVVSSVVIIVATIWYTLREIDR----AEAAMAAEYERSEELL MSMEG_3578|M.smegmatis_MC2_155 -SAGDYGVALPVVSRDEFGDLTVAFNEMSRNLRIKEDLLDEQRKENDRLL TH_2298|M.thermoresistible__bu -ATGDYHVRLPVTSHDEFGDLTAAFNDMSRNLATKEELLAEQRRENDRLL Mb2461c|M.bovis_AF2122/97 -SAGDYEVNIPVKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLL Rv2435c|M.tuberculosis_H37Rv -SAGDYEVNIPVKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLL MMAR_3757|M.marinum_M -SGGDYDVAIPVKSRDEIGDLTAAFNEMSRSLNIKEDLLNEQRRENDRLL MAV_1745|M.avium_104 -SSGDYDINIPVRARDEIGDLTAAFNEMSRNLAIKEELLNEQRRENDRLL MUL_3698|M.ulcerans_Agy99 -RSGDYEVTVPVKSRDELGDLTAAFNEMSSNLKVKDQLLTEQRSQNEQLL MAB_0490c|M.abscessus_ATCC_199 -QRGNYNAHVPIYDASELGLLQAGFNDMVRDLG--------ERQRLRDLF MLBr_02341|M.leprae_Br4923 AAGNPFFAQEITRELAERGVLTGERGRYACSTDVAEVCVPATLQATIAAR : . : Mflv_3576|M.gilvum_PYR-GCK ANILPATIAERLKEPTRTVIADKYDDASILFADIAGYTKRASDTAPAE-- Mvan_2839|M.vanbaalenii_PYR-1 ANILPATIADRLKEPTRTVIADKYDDASILFADIAGYTKRASETPPSE-- MSMEG_3578|M.smegmatis_MC2_155 LSLMPEPVVQRYRE-GEETIAQDHQNVTVLFADLMGLDRLSASMSSDE-- TH_2298|M.thermoresistible__bu LSLMPEPVVQRYRD-GEQTIAQDHQDVTVIFADIVGLDEVSFNLPSAE-- Mb2461c|M.bovis_AF2122/97 LSMMPEPVVERYRL-GEQTIAQEHQDVTVLFADILGVDEISSGLSGNE-- Rv2435c|M.tuberculosis_H37Rv LSMMPEPVVERYRL-GEQTIAQEHQDVTVLFADILGVDEISSGLSGNE-- MMAR_3757|M.marinum_M LSMMPEPVVQRYRE-GEQTIAQEHQDVTVIFADILGLDEVSRSLSGNE-- MAV_1745|M.avium_104 LALMPESVLQRYRE-GEETIAQKHQDVAIIYADIVGLDELFTEMPEAQ-- MUL_3698|M.ulcerans_Agy99 LALMPEPVVQRYRA-DGEVIAEEHQDVTVIFAELIGLEEISDGLSGDE-- MAB_0490c|M.abscessus_ATCC_199 GRYVGEDVARRALEYGTELGGQE-RSVAVLFVDLVGSTQLASTRGPAV-- MLBr_02341|M.leprae_Br4923 IDRLSPPAKQLLVAAAVIGFRFGSDLLASLGIDLSVDELIDANLVDQVRF : : : :: Mflv_3576|M.gilvum_PYR-GCK LVRFLDLLYTDLDALVDRHGLEKVKTSGDSYMVVSGVPTPRPDHLEALAT Mvan_2839|M.vanbaalenii_PYR-1 LVRFLDRLYTDLDALVDRHGLEKVKTSGDSYMVVSGVPNPRADHLEALAL MSMEG_3578|M.smegmatis_MC2_155 HLSIVNKLVRQFDAAAESLGVERVRTLHNGYLASCGLTVPRLDNVRRTVD TH_2298|M.thermoresistible__bu AVPIVNELIRQFDAAADHHGVERVRTMHNGYIASCGLSVPRLDNVRRTVD Mb2461c|M.bovis_AF2122/97 LVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPRTVD Rv2435c|M.tuberculosis_H37Rv LVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPRTVD MMAR_3757|M.marinum_M LIAIVDDLFRQFDSAAESLGVERIRTLHNGYLASCGVTTPRLDNVARTVA MAV_1745|M.avium_104 LVGTVDELFRQFDSAAETLGVERIRTFHNGYLASCGVVTPRLDSIHRAVD MUL_3698|M.ulcerans_Agy99 LVGIVDELFRQFDSAAQSLGVEPIRTFHNGYLAACGATTPRLDNVHRGIE MAB_0490c|M.abscessus_ATCC_199 VVRVLNEFFRVIVDTVNKHGGFVNKFQGDAALAIFGAPIDHPDGAAAALA MLBr_02341|M.leprae_Br4923 TAPVEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEARAPHSVDQHAV : : . . . . Mflv_3576|M.gilvum_PYR-GCK LALDMSEAVADLKDPRGRDVPLRIGMAMGPVVAGVVGAKK--------FF Mvan_2839|M.vanbaalenii_PYR-1 LALDMADAVADLKDPQGHDVPLRIGMASGPVVAGVVGAKK--------FF MSMEG_3578|M.smegmatis_MC2_155 FAFEMQRIVDRFRGETGYDLRLRAGIDTGTVSSGLVGRSS--------LA TH_2298|M.thermoresistible__bu FALDLQRIIDRFTRETGHRLELRAGIDTGTVKSGLVDRSR--------LA Mb2461c|M.bovis_AF2122/97 FALEMRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSS--------VV Rv2435c|M.tuberculosis_H37Rv FALEMRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSS--------VV MMAR_3757|M.marinum_M FALEMQRIIERFNHQSGHQLRLRAGINTGNVISGLVGRTS--------VV MAV_1745|M.avium_104 FALEIGRIIDRFNSQTGHQLGLRIGVNTGNVVSGLVGRSG--------LV MUL_3698|M.ulcerans_Agy99 FALEIELIVNRFANQSQHPLRVRVGVTTGRVVSGRVGRSN--------LA MAB_0490c|M.abscessus_ATCC_199 AARELSGELTNVLGSND----FGIGVSAGRAIAGHIGAQAR-------FE MLBr_02341|M.leprae_Br4923 LIAEHLEAAGDLHAAYGWHMRAAAWATNQDVRAARVSWEHATKIADALTA : . . :. :. Mflv_3576|M.gilvum_PYR-GCK YDVWGDAVNVASRMETTDEE--GRIQVPDNVYQRLRH--AFVLEERGLID Mvan_2839|M.vanbaalenii_PYR-1 YDVWGDAVNVASRMETTDVE--GRIQVPDNVYERLRD--RFVLEERGVVD MSMEG_3578|M.smegmatis_MC2_155 YDMWGAAVDLAYQVQRGMPQ--PGVYVTDQVHDAVRD--IRQFTAVGSVT TH_2298|M.thermoresistible__bu YDMWGSAVNIAYQVQTGTAK--PGIFVTTRVRDVLRD--TYRFEQAGQID Mb2461c|M.bovis_AF2122/97 YDMWGAAVSLAYQMHSGSPQ--PGIYVTSQVYEAMRD--VWQFTAAGTIS Rv2435c|M.tuberculosis_H37Rv YDMWGAAVSLAYQMHSGSPQ--PGIYVTSQVYEAMRD--VWQFTAAGTIS MMAR_3757|M.marinum_M YDMWGAAVSTAYQMHSGSPQ--PGIYVTSQVYEAMRD--ERQFAPAGTIA MAV_1745|M.avium_104 YDMWGGAVSLAYQMHSGSPQ--PGIYVSSQVYEAMRD--VRQFAPAGTIS MUL_3698|M.ulcerans_Agy99 YDMWGGAVQMAYRMLGHLSD--PGIYVSARVHDAMRE--IWTFTPAGAIS MAB_0490c|M.abscessus_ATCC_199 YTVIGDPVNEAARLTELAKNEPGNVLASASAVMEARDEEALRWDVGETVE MLBr_02341|M.leprae_Br4923 EDPHRAAMCIAPRTRLCGIAWRGRFNSSSGFDEVRQLCNATGDKAPLAVA .: * : . . : : Mflv_3576|M.gilvum_PYR-GCK VKGKGPMHTWYLVGHRARAVTPSSSPP Mvan_2839|M.vanbaalenii_PYR-1 VKGKGPMHTWYLVAHRAEAVTPSGSPT MSMEG_3578|M.smegmatis_MC2_155 VDGT-ERPIWRLSERQS---------- TH_2298|M.thermoresistible__bu IDGA-AEPVWRLTEQRS---------- Mb2461c|M.bovis_AF2122/97 VGGL-EEPIYRLSERS----------- Rv2435c|M.tuberculosis_H37Rv VGGL-EEPIYRLSERS----------- MMAR_3757|M.marinum_M VGGA-EQQIYRMSEQS----------- MAV_1745|M.avium_104 VGGT-DQAIYRLLER------------ MUL_3698|M.ulcerans_Agy99 VRGS-QQQIWQVSERR----------- MAB_0490c|M.abscessus_ATCC_199 LRGRTVSTQVARPRHG----------- MLBr_02341|M.leprae_Br4923 TVGPAIDHVYQDRLH------------ * :