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TGAGIVETTTNRVRHVPVPEPVSERLRDELPTEPNALVFPSYRGGHLPIEEYRRAFDKGCKAVGIADLVP HGLRHTTASLAISAGANVKVVQRLLGHATAAMTLDRHGHLLSDDLAGVAGLLVQAIKSAAASLRYSDPDS VAVENISAAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2309c | - | - | 100% (151) | POSSIBLE INTEGRASE (FRAGMENT) |
| M. tuberculosis H37Rv | Rv1054 | - | 1e-18 | 66.18% (68) | integrase |
| M. tuberculosis H37Rv | Rv3751 | - | 1e-11 | 50.85% (59) | integrase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2335c | - | 2e-82 | 100.00% (151) | hypothetical protein Mb2335c |
| M. gilvum PYR-GCK | Mflv_1985 | - | 1e-08 | 29.93% (147) | phage integrase family protein |
| M. leprae Br4923 | MLBr_01600 | xerC | 6e-09 | 34.31% (102) | site-specific tyrosine recombinase XerC |
| M. abscessus ATCC 19977 | MAB_3204c | xerC | 3e-08 | 33.33% (102) | site-specific tyrosine recombinase XerC |
| M. marinum M | MMAR_4848 | - | 2e-13 | 35.04% (137) | prophage integrase |
| M. avium 104 | MAV_2217 | - | 2e-10 | 36.09% (133) | traSA:integrase fusion protein |
| M. smegmatis MC2 155 | MSMEG_2515 | xerC | 7e-08 | 34.31% (102) | site-specific tyrosine recombinase XerC |
| M. thermoresistible (build 8) | TH_0846 | xerC | 2e-08 | 34.65% (101) | PROBABLE INTEGRASE/RECOMBINASE XERC |
| M. ulcerans Agy99 | MUL_0529 | - | 2e-11 | 34.75% (118) | prophage integrase |
| M. vanbaalenii PYR-1 | Mvan_2207 | xerC | 1e-08 | 36.27% (102) | site-specific tyrosine recombinase XerC |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2515|M.smegmatis_MC2_155 --------------------------------------------------
TH_0846|M.thermoresistible__bu --------------------------------------------------
Mvan_2207|M.vanbaalenii_PYR-1 ------------------------------------------MVCHGRGV
MLBr_01600|M.leprae_Br4923 --------------------------------------------------
MAB_3204c|M.abscessus_ATCC_199 --------------------------------------------------
Rv2309c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 ----------MDLWTKTVRDPDDTIRTVPSARHGRGM-RWRATYVDDQSR
MMAR_4848|M.marinum_M ------------MAGSVPRGIRKRTNSAGQARYQVRY-LVRDPNSPSGWV
MUL_0529|M.ulcerans_Agy99 ------------MAGNTPRGIRKRLNAAGEPRYQVRY-LIRDPDAPSGWV
Mflv_1985|M.gilvum_PYR-GCK MAYVRAHDTKQRRNGKVVKTYAVVWREAVRDEFGLPTGATRARRETYPTR
MSMEG_2515|M.smegmatis_MC2_155 -----------MESVLDQFDAYLGLERGHSD-----HTRRAYRGDLTALF
TH_0846|M.thermoresistible__bu ---------MSVDTVLDEFADYLALQRGRSP-----HTCRAYLGDLRSLF
Mvan_2207|M.vanbaalenii_PYR-1 QTGGQERSDPGIGSCLEEFDEYLALERGRSE-----HTRRAYLGDVRALF
MLBr_01600|M.leprae_Br4923 ------------MAILDEFDEHLALRCGRSE-----HTRRAYLGDLRSLL
MAB_3204c|M.abscessus_ATCC_199 -------MTPQLAAILDEFAEHLALERGRSV-----HTQRAYRGDLTLLF
Rv2309c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 EHSRSFGRKVDAQRWLDEVT-AAVVTGQYVDPKAGQITFRDYAERWR--K
MMAR_4848|M.marinum_M ETSSTFATMREARAFKADRDGEAAIGARRFDPRLGRASLSAIWTQYSASK
MUL_0529|M.ulcerans_Agy99 ETSATFPTLREAKAFKSERDNEAALGARRFDPRLGRTPLSRIWTQFSDSK
Mflv_1985|M.gilvum_PYR-GCK DAAEVRRDELNAAKHTHAGTSALAEQRAKGEQPFGFYARAWLDAQAVRVA
MSMEG_2515|M.smegmatis_MC2_155 DFVEQRTGERSLARVSLPLLRSWLAEQSASGAARTTLARRTS--------
TH_0846|M.thermoresistible__bu DFVEQRSPGSGLGGLSLPVLRAWLAAQAADGSARTTLARRTS--------
Mvan_2207|M.vanbaalenii_PYR-1 DFLAERRPGTGLRGLTLPVLRSWLAAQATAGAARSTLARRTS--------
MLBr_01600|M.leprae_Br4923 THLEGR--GSRLDQLSLPVLRSWLATAAGAGAARTTLARRIS--------
MAB_3204c|M.abscessus_ATCC_199 DHLSASNPEATLADLSLPVLRSWLGAQARQGAARSTVARRTS--------
Rv2309c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 MQVQRPSSRAHIETMLRRHAYPTLGDRQLTSILPSDVQAWVKGLQ-----
MMAR_4848|M.marinum_M QPAVSPKTWSGYAQHWELRISPRFGHVPVDEISRKDVQQFIGGLT-----
MUL_0529|M.ulcerans_Agy99 KPAVSPKTWSGYNQHWELRIKPRFGHVPVDEITRADVRAFVDGLT-----
Mflv_1985|M.gilvum_PYR-GCK SGKVKQRTVDEYERQLHTYVLGELGSLAVAAVTPAHLERLLTGLVRRQSR
MSMEG_2515|M.smegmatis_MC2_155 ---------SVKTFCAWALRRGLIGVDPAARLQVPKARRTLPAVLRRD--
TH_0846|M.thermoresistible__bu ---------AVKTFTAWAVRQGLLSTDPALRLQVPKARRTLPAVLRRD--
Mvan_2207|M.vanbaalenii_PYR-1 ---------AVKTFTAWAVRRGLMTEDPAARLQVPKARRTLPSVLRQD--
MLBr_01600|M.leprae_Br4923 ---------AVKAFTAWAKWRGQLAADPAARLQVPRAYRTLPAVLRQD--
MAB_3204c|M.abscessus_ATCC_199 ---------AVKIFTAWATRRGLLPTDPAIRLQQPKSRRTLPAVLRQD--
Rv2309c|M.tuberculosis_H37Rv ----------------------------------MTGAGIVETTTNRV--
Mb2335c|M.bovis_AF2122/97 ----------------------------------MTGAGIVETTTNRV--
MAV_2217|M.avium_104 ------LAPATVGVVHGLVSTVMKSAIRDRRLAANPCDGTKLPKVQRP--
MMAR_4848|M.marinum_M ------VGPWAKLATLRLLRSILDMAREDGRIHINPAQGVSSGRIPAR--
MUL_0529|M.ulcerans_Agy99 ------VGPWAKVSTLRLLRSILDVAHQDGRIHRNPALGVSAGRIPER--
Mflv_1985|M.gilvum_PYR-GCK QGDRKPITPGTVKHVWDVVRRVLKYAVKHGALDSNPADRVDFSASRATGD
MSMEG_2515|M.smegmatis_MC2_155 ----QALDALDAVNSGAQEGDPIALRDRL-------------IVELLYAT
TH_0846|M.thermoresistible__bu ----QALAAMAAADSGAQQKDPIALRDRL-------------IVEMLYAT
Mvan_2207|M.vanbaalenii_PYR-1 ----QAREAMDAAKSGAQQGDPLALRDRL-------------IVEMLYAT
MLBr_01600|M.leprae_Br4923 ----QALQIMAAAKSGAEQGDPLALRDRL-------------IVEMLYAT
MAB_3204c|M.abscessus_ATCC_199 ----QAAAAMEAAHSGAEQDDPMALRDRL-------------IVEMLYAT
Rv2309c|M.tuberculosis_H37Rv ----RHVPVPEPVSERLRDELPTEPNA---------------LVFPSYRG
Mb2335c|M.bovis_AF2122/97 ----RHVPVPEPVSERLRDELPTEPNA---------------LVFPSYRG
MAV_2217|M.avium_104 ----QIVPLTTEQVEAVRAELPAELQA---------------LVTLAAGT
MMAR_4848|M.marinum_M ----ERHRYLSATEVAALAHACGDQGD---------------IVTILAFT
MUL_0529|M.ulcerans_Agy99 ----ERHRYLTAQEVRMLATACGDQGD---------------VVTILAYT
Mflv_1985|M.gilvum_PYR-GCK HAEFEHHPLTAAQVGALSAAVAGHAREGYEGPELPAYPVYGLLVEFLAYT
. :*
MSMEG_2515|M.smegmatis_MC2_155 GIRVSELCGLDIDDIDTSRRVVRVLGKGNKQRT----VPFGEPAHAALTA
TH_0846|M.thermoresistible__bu GIRVSELCGLDIDDVDTDRHLARVLGKGGRQRT----VPFGEPARGALTD
Mvan_2207|M.vanbaalenii_PYR-1 GIRVSELCGLDIDDVDTARRLLRVLGKGNKQRT----VPYGDPAHAALTA
MLBr_01600|M.leprae_Br4923 GIRVSELCGLDIDDVDTRHRLVRVLGKGNKQRT----APFGVPAADALRG
MAB_3204c|M.abscessus_ATCC_199 GIRVSELCGLDIDDIDRPRKVLRVLGKGDKERT----VPFGDPAADALSA
Rv2309c|M.tuberculosis_H37Rv GHLPIEEY------------------------------------------
Mb2335c|M.bovis_AF2122/97 GHLPIEEY------------------------------------------
MAV_2217|M.avium_104 GLRQGECFGLTVDRVRFLERVLTVDRQLVTVAGQ--APTFGPPKTRASNR
MMAR_4848|M.marinum_M GLRWSELVGLRVGDIDLKARRLYVRQAAPDVEG---RIIVGPPKTRAAVR
MUL_0529|M.ulcerans_Agy99 GLRWSEPVGLRVKDIDLTARRLYVRRAAPEVEG---HIVIGPPKTRAGIR
Mflv_1985|M.gilvum_PYR-GCK GLRAAEAAGLEVADLLFSPGPRCSVRVARTKDRKNGVWVVGTPKSKRSRR
* *
MSMEG_2515|M.smegmatis_MC2_155 WLTEGRPQLSIPESGPALLLGARGRRLDP---------------------
TH_0846|M.thermoresistible__bu WLTDGRPALATAESGPALLLGVRGRRLDP---------------------
Mvan_2207|M.vanbaalenii_PYR-1 WLSDGRPALVTAGSGAALLLGARGGRLDP---------------------
MLBr_01600|M.leprae_Br4923 WLDDGRPALVTVESGPALLLGSRGRRLDV---------------------
MAB_3204c|M.abscessus_ATCC_199 WLDRGRPHLAVPASGAALLLGARGRRVDP---------------------
Rv2309c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 AIPLPKVVADALAAHLAAFPAEPDGLV-----FTQQG-------------
MMAR_4848|M.marinum_M TVPLPRIVIDALKPRIENRSTKEQAITSPNGGFLRSN-------------
MUL_0529|M.ulcerans_Agy99 TVPLPQVVVDIFKGRITGQAPDQPAVTSTNGAMLRSN-------------
Mflv_1985|M.gilvum_PYR-GCK TVPLPPWLAKRMADYLAEVHPRGDEPNAPLWPSRRNGGGHRAVGQRYAVP
MSMEG_2515|M.smegmatis_MC2_155 ---------RQARTVVHQTVSAVNGAPDIGPHG-------------LRHS
TH_0846|M.thermoresistible__bu ---------RQARTVVHQTVAAVAGAPDIGPHG-------------LRHS
Mvan_2207|M.vanbaalenii_PYR-1 ---------RQARTVVHQTMAAVSGAPDIGPHG-------------LRHS
MLBr_01600|M.leprae_Br4923 ---------RQARTVVHQTVAVVAGAPDMGPHG-------------LRHS
MAB_3204c|M.abscessus_ATCC_199 ---------RQVRTVVHQTMSAVPGAPDIGPHG-------------LRHS
Rv2309c|M.tuberculosis_H37Rv -------------RRAFDKGCKAVGIADLVPHG-------------LRHT
Mb2335c|M.bovis_AF2122/97 -------------RRAFDKGCKAVGIADLVPHG-------------LRHT
MAV_2217|M.avium_104 ---------KPITRSTFGYRWRAAVKEAKLPHGTGF--------HALRHY
MMAR_4848|M.marinum_M ---------NWRRHTHWNKALKKTGLAPLTIHD-------------LRHT
MUL_0529|M.ulcerans_Agy99 ---------NWRRHTHWNKALKSTDLAPLTIHD-------------LRHT
Mflv_1985|M.gilvum_PYR-GCK LDWSQPLALGTFYDTILKPALEAVGLPATRPATKDAPAIRGVRLHDLRHT
***
MSMEG_2515|M.smegmatis_MC2_155 AATHLLEGGADLRIVQELLGHTS-LATTQLYTHVTVERLRAVHDQAHPRA
TH_0846|M.thermoresistible__bu AATHLLEGGADLRIVQELLGHTS-LATTQLYTHVTVERLRAVHDQAHPRA
Mvan_2207|M.vanbaalenii_PYR-1 AATHLLEGGADLRVVQELLGHSS-LATTQLYTHVTVARLRAVHDQAHPRA
MLBr_01600|M.leprae_Br4923 AATHLLEGGADLRVVQELLGHSS-LATTQLYTHVAVSRLRVVHDQAHPRA
MAB_3204c|M.abscessus_ATCC_199 AATHLLEGGADLRVVQELLGHST-LATTQLYTHVTVARLRAVHDQAHPRA
Rv2309c|M.tuberculosis_H37Rv TASLAISAGANVKVVQRLLGHATAAMTLDRHGHLLSDDLAGVAGLLVQAI
Mb2335c|M.bovis_AF2122/97 TASLAISAGANVKVVQRLLGHATAAMTLDRHGHLLSDDLAGVAGLLVQAI
MAV_2217|M.avium_104 YASLLIRHGESVKTVQARLGHASAVETLDTYSHLWPDSDDRTRDAIDSVL
MMAR_4848|M.marinum_M YASLARKSGADLRYVQKTMGHSTPTVTANIYSDLYSDELDHVATNLDRLN
MUL_0529|M.ulcerans_Agy99 YASLARKSGADLRYVQKTMGHSTPTVTANIYSDLYADELDQVATNLDQLH
Mflv_1985|M.gilvum_PYR-GCK FAVLQLSAGTHFMQVSKWLGHSTYTLTLDVYGDYIPEEDGGAANNLPEPP
* * . *. :**:: * : : . .
MSMEG_2515|M.smegmatis_MC2_155 ------------------------
TH_0846|M.thermoresistible__bu ------------------------
Mvan_2207|M.vanbaalenii_PYR-1 ------------------------
MLBr_01600|M.leprae_Br4923 ------------------------
MAB_3204c|M.abscessus_ATCC_199 ------------------------
Rv2309c|M.tuberculosis_H37Rv KSAAASLRYSDPDSVAVENISAAS
Mb2335c|M.bovis_AF2122/97 KSAAASLRYSDPDSVAVENISAAS
MAV_2217|M.avium_104 GSTAYRLRTGQPATS---------
MMAR_4848|M.marinum_M DVAKDQAN-GQEPDTPKHP-----
MUL_0529|M.ulcerans_Agy99 ATEIQTPTTGQEPDEPNQPSSA--
Mflv_1985|M.gilvum_PYR-GCK APQRPLEAVDNVVPLRRES-----