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VKLLSPLDQMFARMEAPRTPMHIGAFAVFDLPKGAPRRFIRDLYEAISQLAFLPFPFDSVIAGGASMAYW RQVQPDPSYHVRLSALPYPGTGRDLGALVERLHSTPLDMAKPLWELHLIEGLTGRQFAMYFKAHHCAVDG LGGVNLIKSWLTTDPEAPPGSGKPEPFGDDYDLASVLAAATTKRAVEGVSAVSELAGRLSSMVLGANSSV RAALTTPRTPFNTRVNRHRRLAVQVLKLPRLKAVAHATDCTVNDVILASVGGACRRYLQELGDLPTNTLT ASVPVGFERDADTVNAASGFVAPLGTSIEDPVARLTTISASTTRGKAELLAMSPNALQHYSVFGLLPIAV GQKTGALGVIPPLFNFTVSNVVLSKDPLYLSGAKLDVIVPMSFLCDGYGLNVTLVGYTDKVVLGFLGCRD TLPHLQRLAQYTGAAFEELETAALP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2285 | - | - | 100% (445) | hypothetical protein Rv2285 |
| M. tuberculosis H37Rv | Rv3480c | - | 4e-73 | 36.65% (483) | hypothetical protein Rv3480c |
| M. tuberculosis H37Rv | Rv3740c | - | 1e-68 | 36.17% (459) | hypothetical protein Rv3740c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2306 | - | 0.0 | 100.00% (445) | hypothetical protein Mb2306 |
| M. gilvum PYR-GCK | Mflv_1058 | - | 8e-77 | 39.75% (473) | hypothetical protein Mflv_1058 |
| M. leprae Br4923 | MLBr_01244 | - | 4e-27 | 30.75% (348) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_4544c | - | 3e-54 | 30.58% (448) | hypothetical protein MAB_4544c |
| M. marinum M | MMAR_3431 | - | 0.0 | 86.43% (442) | hypothetical protein MMAR_3431 |
| M. avium 104 | MAV_0126 | - | 4e-65 | 35.79% (461) | bifunctional wax ester synthase/acyl-CoA diacylglycerol |
| M. smegmatis MC2 155 | MSMEG_6322 | - | 2e-65 | 35.37% (458) | bifunctional wax ester synthase/acyl-CoA diacylglycerol |
| M. thermoresistible (build 8) | TH_2030 | - | 5e-62 | 34.80% (454) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2706 | - | 0.0 | 85.97% (442) | hypothetical protein MUL_2706 |
| M. vanbaalenii PYR-1 | Mvan_5773 | - | 3e-77 | 39.01% (464) | hypothetical protein Mvan_5773 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2285|M.tuberculosis_H37Rv ----MKLLSPLDQM----FARMEAPRTPMHIGAFAVFDLP-KGAPRRFIR
Mb2306|M.bovis_AF2122/97 ----MKLLSPLDQM----FARMEAPRTPMHIGAFAVFDLP-KGAPRRFIR
MMAR_3431|M.marinum_M ----MKLLSPLDQM----FARMEAPRTPMHIGAFAIFDMP-KNAPRGFIR
MUL_2706|M.ulcerans_Agy99 ----MKLLSPLDQM----FARMEAPRTPMHIGAFAIFDMP-KNAPRGFIR
Mflv_1058|M.gilvum_PYR-GCK MSANSVRLGLQDLM----FIYGETSSSKMHVGGLLPFTPP-ADAPRDYLR
Mvan_5773|M.vanbaalenii_PYR-1 -------------M----FIYGETSSSKMHVAGLLPFTPP-ADAPRDYLR
MSMEG_6322|M.smegmatis_MC2_155 -MNRMQLMSPTDSM----FLIAESREHPMHVGGLALYDPP-DDAGPEFVR
TH_2030|M.thermoresistible__bu ----MRLISPADSM----FLLAESREHPMHVAGLQLFEPPPGTAGPEFLQ
MAV_0126|M.avium_104 ----MEPISPTDAL----FLIGESREHPMHVGSLQLFEPP-PDAGPHFVR
MAB_4544c|M.abscessus_ATCC_199 ----MPFMPVSDSM----FLIGETREHPFHVGGLQLFKPP-VDAGPDYAE
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTPDWNRFR
: : . ..: . .
Rv2285|M.tuberculosis_H37Rv DLYEAISQLAFLPFPFDSVIAG-----GASMAYWRQVQPDPSYHVRLSAL
Mb2306|M.bovis_AF2122/97 DLYEAISQLAFLPFPFDSVIAG-----GASMAYWRQVQPDPSYHVRLSAL
MMAR_3431|M.marinum_M DLYEAVSQLAFLPFPFDSVIAG-----GPSMAYWKQVQPDPSYHVRMSAL
MUL_2706|M.ulcerans_Agy99 DLYEAVSQLAFLPFPFDSVIVG-----GPSMAYWKQVQPDPSSHVRMSAL
Mflv_1058|M.gilvum_PYR-GCK GMIDEARRQEVVA-PWNRRLAYPRLQFSPLHSWVTDEDFDFDYHVRRSAL
Mvan_5773|M.vanbaalenii_PYR-1 RMVDDARRQEVMP-PWNRKLAYPRLQFSPLHTWVTDTEFDFDYHVRRSAL
MSMEG_6322|M.smegmatis_MC2_155 ELYEEMVRHTDFQPVFRKHPAT-LLGGIANVGWTLDDEVDLDYHLRRSAL
TH_2030|M.thermoresistible__bu GLHQRLAAGRELHPTFRKHPAT-LFGGIAHLGWAVDDDVDFDYHLRRSAL
MAV_0126|M.avium_104 ESYQAMLECTDVQPTFRKHPA--FFGGVTNLAWSIDKEVELDYHLRRSAL
MAB_4544c|M.abscessus_ATCC_199 VFYEQLMSTTEVSSDFRKRPGQ-PLAVMGNLTWIVDDEVDWEYHVRRSAL
MLBr_01244|M.leprae_Br4923 SRIEDVSQRVLRLRQKVVVPTLP----TAAPRWVVDPDFELDFHVRRVRV
: : : : : . *:* :
Rv2285|M.tuberculosis_H37Rv PYPGTGRDLGALVERLHSTPLDMAKPLWELHLIEGLTGRQFAMYFKAHHC
Mb2306|M.bovis_AF2122/97 PYPGTGRDLGALVERLHSTPLDMAKPLWELHLIEGLTGRQFAMYFKAHHC
MMAR_3431|M.marinum_M PQPGTARDLGALVERLHSTPLDMTKPLWELHVIEGLEGKQFAIYFKAHHC
MUL_2706|M.ulcerans_Agy99 PQPGTARDLGALVERLHSTPLDMTKPLWELHVIEGLEGKQFAIYFKAHHC
Mflv_1058|M.gilvum_PYR-GCK ASPGDERELGVLVSRLHSNHLDLTRPPWELHVIEGLEGGRFALYMKIHHA
Mvan_5773|M.vanbaalenii_PYR-1 ASPGDERELGILVSRLHSNHLDLTRPPWELHVIEGLEGGRFALYMKIHHA
MSMEG_6322|M.smegmatis_MC2_155 PSPGRPRELLELTSRVHGTLLDRHRPLWEAYLIEGMADGRFAVYTKVHHS
TH_2030|M.thermoresistible__bu PGPGRIRELLDLTSRWHGTLLDRHRPLWEVHLVEGLADGRVAIYFKVHHA
MAV_0126|M.avium_104 PEPGRVRDLLELASRLHGSLLDRHRPLWEAHLVEGLQDGRYAVYTKYHHS
MAB_4544c|M.abscessus_ATCC_199 PRPARVRELLTVTSRWHSSPLDRHRPLWEMHVVEGLSDGRLAVYTKMHHA
MLBr_01244|M.leprae_Br4923 PDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQISHA
. *. *:: :.. : . :* :* * ::**: : *: : *.
Rv2285|M.tuberculosis_H37Rv AVDGLGGVNLIKSWLTTDPEAP----------PGSGKPEPFGDDYD---L
Mb2306|M.bovis_AF2122/97 AVDGLGGVNLIKSWLTTDPEAP----------PGSGKPEPFGDDYD---L
MMAR_3431|M.marinum_M AVDGMGGVNLIKSWLTTDPTAP----------PGSGKPEPLGDDYD---L
MUL_2706|M.ulcerans_Agy99 AVDGMGGVNLIKSWLTTDPTAP----------PGSGKPEPLGDDYD---L
Mflv_1058|M.gilvum_PYR-GCK LVDGYSAMRMLGRSLSTDPASRDTRMFFNVPSPTRSRRDPGAAESSNPLT
Mvan_5773|M.vanbaalenii_PYR-1 LVDGYTAMRMLGRSLSTDPETRDARMFFNVPIPKRSRPTGAGAQSSNPVT
MSMEG_6322|M.smegmatis_MC2_155 LIDGVSAMKLVERTLSEDPSDTTVRVPWN--LPRRESSRRAGSSS-----
TH_2030|M.thermoresistible__bu LIDGVAVMKLMQRTLSTDPGDD-ARVPWN--LPPPRRNP-AGPVS-----
MAV_0126|M.avium_104 LMDGVSALRLVQRAFTPDPDDDEVRVPWS--LAPRQRGPRRRPSL-----
MAB_4544c|M.abscessus_ATCC_199 VIDGVGALRMMMRSLSDDPDARDCQAVWA--PAKRRAKSSIVSTTNTSAI
MLBr_01244|M.leprae_Br4923 ITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGINHLPV
** :.:. :
Rv2285|M.tuberculosis_H37Rv ASVLAAATTKRAVEG-VSAVSELAGRLSSMVL---GANSSVRAALTTPRT
Mb2306|M.bovis_AF2122/97 ASVLAAATTKRAVEG-VSAVSELAGRLSSMVL---GANSSVRAALTTPRT
MMAR_3431|M.marinum_M ATVFAATTAKRAVEG-VSAVSELIGKIISMAR---GANSSVRAALTTPGT
MUL_2706|M.ulcerans_Agy99 ATVFAATTAKRAVEG-VSAVSELIGKIISMAL---GANSSVRAALTTPGT
Mflv_1058|M.gilvum_PYR-GCK ATLRALGGVSSAVTGGVSSAVDLTNALVNTQIRRDGENAHIAGSVSAPHS
Mvan_5773|M.vanbaalenii_PYR-1 ATLRALGAVGSTVSDGVGSAVDLASALVNTQIRRDGDFGRISGSASAPHS
MSMEG_6322|M.smegmatis_MC2_155 -LARTATGAATSLAALAPSTIRLARAALLEQQ--------LTLPFGAPRT
TH_2030|M.thermoresistible__bu -RLRSATGAVGSVAALAPSTLSLARAALLEQR--------LTLPFGAPRT
MAV_0126|M.avium_104 -LERAGR-TAGSALALAPSTLKLARAALLEQQ--------LTLPFQAPRS
MAB_4544c|M.abscessus_ATCC_199 DLVKGAAGAVRQVVSIPPGLLKYGRHALSDPQ--------LVKPLSAPHT
MLBr_01244|M.leprae_Br4923 ALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQAAEPSP
: * .
Rv2285|M.tuberculosis_H37Rv PFNTRVNRHRRLAVQVLKLPRLKAVAHATDCTVNDVILASVGGACRRYLQ
Mb2306|M.bovis_AF2122/97 PFNTRVNRHRRLAVQVLKLPRLKAVAHATDCTVNDVILASVGGACRRYLQ
MMAR_3431|M.marinum_M PFNTRINRHRRLAVQVLSLPRLKAVSSATGTTINDVVLASIGGACRHYLR
MUL_2706|M.ulcerans_Agy99 PFNTRINRHRRLAVQVLSLPRLKAVSSATGTTINDVVLASIGGACRHYLR
Mflv_1058|M.gilvum_PYR-GCK ILNARISRNRRFATQQYEFDRLKKLSSQHGATLNDVALAIIGGGLRKFLS
Mvan_5773|M.vanbaalenii_PYR-1 ILNARISRNRRFATQQYEFDRLKKLSSQHGATINDVALAIIGGGLRKFLA
MSMEG_6322|M.smegmatis_MC2_155 MFNVKIGGARRVAAQSWPLERLRRIKAVTGATINDIVLAMCAGALRAYLA
TH_2030|M.thermoresistible__bu MFNVRIGGARRVAAQSWPLQRIRRIRQAAGXTLNDVALAMCAGALRQYLL
MAV_0126|M.avium_104 MFNVRIGGARRVAAQSWPLERINAVKAATGATVNDVILAMSSGALRAYLL
MAB_4544c|M.abscessus_ATCC_199 MLNVSIGGARRFAAQTWSMARIKEAGKALGGTVNDVVLAMCGGALRTYLE
MLBr_01244|M.leprae_Br4923 LLRQRS-LATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRRYHE
:. * . : :. . ::** ** *. * :
Rv2285|M.tuberculosis_H37Rv ELGDLPTNTLTASVPVGFE-RDADT--VNAASGFVAPLGTSIEDPVARLT
Mb2306|M.bovis_AF2122/97 ELGDLPTNTLTASVPVGFE-RDADT--VNAASGFVAPLGTSIEDPVARLT
MMAR_3431|M.marinum_M DQSALPKSNLTVSVPVGFE-RDADT--VNAASGFVTQLGTSIEDPIERLT
MUL_2706|M.ulcerans_Agy99 DQSALPKSNLTVSVPVGFE-RDADT--VNAASGFVTQLGTSVEDPIERLT
Mflv_1058|M.gilvum_PYR-GCK DFDKLPDRSLIAFLPVNVR-PKGDEGGGNAVGAILAPMGTDIEDPVERLD
Mvan_5773|M.vanbaalenii_PYR-1 DLGELPDRSLIAFLPVNVR-PKGDEGGGNAVGAILAPMGTDIEDPVERLA
MSMEG_6322|M.smegmatis_MC2_155 EQDALPDRPLIAMVPVSMRSEHEADAGGNMVGSILCSLGTDVEDPADRLA
TH_2030|M.thermoresistible__bu EHDALPATPLVAMVPVSLRSADESAGGGNRTGLVLCNLATDSDDPAERLD
MAV_0126|M.avium_104 DQNALPDAPLTAMVPVNLRKPDD-DRGGNLVGTFLCNLATDLDDPAKRLE
MAB_4544c|M.abscessus_ATCC_199 EQNALPDKPLVAMCPVSIRAEGD-QNAGNSITALLANLATDKPDPLERFS
MLBr_01244|M.leprae_Br4923 ALG-VSISTLPMAVPVNVR-TEADVVGSNRFVGVTLAAPLGTNDPAARMQ
. :. * **... * . . ** *:
Rv2285|M.tuberculosis_H37Rv TISASTTRGKAELLAMSPNALQHYSVFGLLPIAVG-QKTGALGVIPP---
Mb2306|M.bovis_AF2122/97 TISASTTRGKAELLAMSPNALQHYSVFGLLPIAVG-QKTGALGVIPP---
MMAR_3431|M.marinum_M TISASTSRGKAELLALSPNALQHYSVFGLLPIAVG-QKSGALGIIPP---
MUL_2706|M.ulcerans_Agy99 TISASTSRGKAELLALSPNALQHYSVFGLLPIAVG-QKSGALGIIPP---
Mflv_1058|M.gilvum_PYR-GCK TITTATRAAKGQLQSMSPAAIIAYSAA-LLAPAGS-QIAGALTGVQPPWP
Mvan_5773|M.vanbaalenii_PYR-1 VITAATRASKAQLQSMSPAAIIAYSAA-LLAPAGG-QIAGALTGVNPPWP
MSMEG_6322|M.smegmatis_MC2_155 VIRRSITDNKRVFSELPRLQALALSALLIAPLGLTTAFPGFVDATAP---
TH_2030|M.thermoresistible__bu RISSSMRSNKRVFSQLPRVQAMALSAAMIAPLGLG-AVPGVVSSAPP---
MAV_0126|M.avium_104 IISASIRDTKEVFWQLPPVQQLALSAFNIGGLFFG-LIPGYLSTASP---
MAB_4544c|M.abscessus_ATCC_199 AIRDSVQAAKSVLSEMTPLQRMLVGALNGAPVLTG-AVPGLVDRTAP---
MLBr_01244|M.leprae_Br4923 KIRSQMTQ-RRDEPAMNIIGSLAPLMTVLPASVLDFIVDSVASSDVNASN
* : : .
Rv2285|M.tuberculosis_H37Rv -LFNFTVSNVV-LSKDPLYLSGAKLDVIVPMSFLCDGYGLNVTLVGYTDK
Mb2306|M.bovis_AF2122/97 -LFNFTVSNVV-LSKDPLYLSGAKLDVIVPMSFLCDGYGLNVTLVGYTDK
MMAR_3431|M.marinum_M -LFNFTVSNVV-LSKEPLYLSGAKLDVIVPMSFLCDGYGLNVTLVGYTDK
MUL_2706|M.ulcerans_Agy99 -LFNFTVSNVV-LSKEPLYLSGAKLDVIVPMSFLCDGYGLNVTLVGYTDK
Mflv_1058|M.gilvum_PYR-GCK YTFNLCVSNVP-GPREPLYFNGSRLEATYPVSIPIHGMALNITLQSYADT
Mvan_5773|M.vanbaalenii_PYR-1 HTFNLCVSNVP-GPREPLYFNGSRLEATFPVSIPIHGMALNITLQSYADT
MSMEG_6322|M.smegmatis_MC2_155 -PFNLVISNVP-GPKKPLYWRGARLAGNYPLSIALDGQALNMTVVSNAHN
TH_2030|M.thermoresistible__bu -PFNLVISNVP-GAPEPRYWMGARLAGNYPLSIVLDGQALNITLVTNADN
MAV_0126|M.avium_104 -PFNIVISNVSTGRSERLYWRGARLDGNYPLSIPLDGQAVNITVTNNADN
MAB_4544c|M.abscessus_ATCC_199 -AFNVIISNVP-GPRTDMFWNGFEMDGCYPASIPIDGVALNITCTSSGSS
MLBr_01244|M.leprae_Br4923 IPAYPGDTYFAGAKILRQYGIGPRPGVAMMAVLMSRGGFCTVTVRYDRAS
: . : * . : * .:* .
Rv2285|M.tuberculosis_H37Rv VVLGFLGCRDTLPHLQRLAQYTGAAFEELETAALP--------------
Mb2306|M.bovis_AF2122/97 VVLGFLGCRDTLPHLQRLAQYTGAAFEELETAALP--------------
MMAR_3431|M.marinum_M VVLGFLGCRDTLPHLQRLARYTGEAFDELETATTTA-------------
MUL_2706|M.ulcerans_Agy99 VVLGFLGCRDTLPHLQRLARYTGEAFDELETATTTA-------------
Mflv_1058|M.gilvum_PYR-GCK MNLGFVGCRDRLPHLQRLAVYTGDALAELEAASQI--------------
Mvan_5773|M.vanbaalenii_PYR-1 MNLGFVGCRDRLPRLQRLAVYTGDALGELEAASS---------------
MSMEG_6322|M.smegmatis_MC2_155 LDFGLVGCRRSVPHLQRLLGHLETSLKDLETATGA--------------
TH_2030|M.thermoresistible__bu LDFGLVGARGSVPHLQRLLGHLEDSLQQLERAVGG--------------
MAV_0126|M.avium_104 LDFGLVGCRRSVPHLQRMLGHLEASLKELELAAGV--------------
MAB_4544c|M.abscessus_ATCC_199 MHFGLTGCRTSVPHLQRILAHLEDALTQLEESVA---------------
MLBr_01244|M.leprae_Br4923 VKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAARSSGSPAGWLSSS
: .* : ::.: . . :