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NRMQLMSPTDSMFLIAESREHPMHVGGLALYDPPDDAGPEFVRELYEEMVRHTDFQPVFRKHPATLLGGI ANVGWTLDDEVDLDYHLRRSALPSPGRPRELLELTSRVHGTLLDRHRPLWEAYLIEGMADGRFAVYTKVH HSLIDGVSAMKLVERTLSEDPSDTTVRVPWNLPRRESSRRAGSSSLARTATGAATSLAALAPSTIRLARA ALLEQQLTLPFGAPRTMFNVKIGGARRVAAQSWPLERLRRIKAVTGATINDIVLAMCAGALRAYLAEQDA LPDRPLIAMVPVSMRSEHEADAGGNMVGSILCSLGTDVEDPADRLAVIRRSITDNKRVFSELPRLQALAL SALLIAPLGLTTAFPGFVDATAPPFNLVISNVPGPKKPLYWRGARLAGNYPLSIALDGQALNMTVVSNAH NLDFGLVGCRRSVPHLQRLLGHLETSLKDLETATGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6322 | - | - | 100% (457) | bifunctional wax ester synthase/acyl-CoA diacylglycerol acyltransferase |
| M. smegmatis MC2 155 | MSMEG_4297 | - | 4e-60 | 32.56% (473) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_1882 | - | 2e-44 | 30.44% (473) | acyltransferase, ws/dgat/mgat subfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3761c | - | 1e-178 | 67.62% (454) | hypothetical protein Mb3761c |
| M. gilvum PYR-GCK | Mflv_1058 | - | 5e-90 | 40.22% (465) | hypothetical protein Mflv_1058 |
| M. tuberculosis H37Rv | Rv3734c | - | 1e-178 | 67.62% (454) | hypothetical protein Rv3734c |
| M. leprae Br4923 | MLBr_01244 | - | 2e-23 | 26.93% (349) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_4544c | - | 1e-129 | 49.67% (455) | hypothetical protein MAB_4544c |
| M. marinum M | MMAR_5271 | - | 0.0 | 68.06% (454) | hypothetical protein MMAR_5271 |
| M. avium 104 | MAV_0355 | - | 0.0 | 69.76% (453) | bifunctional wax ester synthase/acyl-coadiacylglycerol |
| M. thermoresistible (build 8) | TH_2030 | - | 1e-179 | 68.94% (454) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2057 | - | 1e-175 | 66.67% (453) | hypothetical protein MUL_2057 |
| M. vanbaalenii PYR-1 | Mvan_5773 | - | 7e-87 | 39.57% (465) | hypothetical protein Mvan_5773 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1058|M.gilvum_PYR-GCK MSANSVRLGLQDLM----FIYGETSSSKMHVGGLLPFTPP-ADAPRDYLR
Mvan_5773|M.vanbaalenii_PYR-1 -------------M----FIYGETSSSKMHVAGLLPFTPP-ADAPRDYLR
MSMEG_6322|M.smegmatis_MC2_155 -MNRMQLMSPTDSM----FLIAESREHPMHVGGLALYDPP-DDAGPEFVR
TH_2030|M.thermoresistible__bu ----MRLISPADSM----FLLAESREHPMHVAGLQLFEPPPGTAGPEFLQ
Mb3761c|M.bovis_AF2122/97 ----MDLMMPNDSM----FLFIESREHPMHVGGLSLFEPP-QGAGPEFVR
Rv3734c|M.tuberculosis_H37Rv ----MDLMMPNDSM----FLFIESREHPMHVGGLSLFEPP-QGAGPEFVR
MMAR_5271|M.marinum_M ----MELMMPTDSM----FLFVESREHPMHVGGLSLFEPP-EGAGPDFVR
MAV_0355|M.avium_104 ----MELIMPTDAV----FLLGESREHPMHVGGLQLYQPP-EGAGRNFVR
MUL_2057|M.ulcerans_Agy99 ----MKLIAPTDSM----FLLGESREHPMHVGGLQLFQPP-EDADENFVT
MAB_4544c|M.abscessus_ATCC_199 ----MPFMPVSDSM----FLIGETREHPFHVGGLQLFKPP-VDAGPDYAE
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELL--DTTPDWNR
: :: . .*: : ::
Mflv_1058|M.gilvum_PYR-GCK GMIDEARRQEVVAPWNRRLAYPRLQFSPLHSWVTDEDFDFDYHVRRSALA
Mvan_5773|M.vanbaalenii_PYR-1 RMVDDARRQEVMPPWNRKLAYPRLQFSPLHTWVTDTEFDFDYHVRRSALA
MSMEG_6322|M.smegmatis_MC2_155 ELYEEMVRHTDFQPVFRKHPATLLGGIANVGWTLDDEVDLDYHLRRSALP
TH_2030|M.thermoresistible__bu GLHQRLAAGRELHPTFRKHPATLFGGIAHLGWAVDDDVDFDYHLRRSALP
Mb3761c|M.bovis_AF2122/97 EFTERLVANDEFQPMFRKHPATIGGGIARVAWAYDDDIDIDYHVRRSALP
Rv3734c|M.tuberculosis_H37Rv EFTERLVANDEFQPMFRKHPATIGGGIARVAWAYDDDIDIDYHVRRSALP
MMAR_5271|M.marinum_M NFYEALVANHEFQPTFRKHPATIGGGIARVAWAYDDDLDVDYHVRRSALP
MAV_0355|M.avium_104 DFYKQLVAQPDFQPTFRKHPAKFVGGIANLGWSYDADVDVDYHVRRSALP
MUL_2057|M.ulcerans_Agy99 EAYEAMLGCTDVQPMFRKHPA-FLGAMTNFAWTFDDDVELDYHFRRSALP
MAB_4544c|M.abscessus_ATCC_199 VFYEQLMSTTEVSSDFRKRPGQPLAVMGNLTWIVDDEVDWEYHVRRSALP
MLBr_01244|M.leprae_Br4923 -FRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRRVRVP
. *: * * :.: ::*.** :.
Mflv_1058|M.gilvum_PYR-GCK SPGDERELGVLVSRLHSNHLDLTRPPWELHVIEGLEGGRFALYMKIHHAL
Mvan_5773|M.vanbaalenii_PYR-1 SPGDERELGILVSRLHSNHLDLTRPPWELHVIEGLEGGRFALYMKIHHAL
MSMEG_6322|M.smegmatis_MC2_155 SPGRPRELLELTSRVHGTLLDRHRPLWEAYLIEGMADGRFAVYTKVHHSL
TH_2030|M.thermoresistible__bu GPGRIRELLDLTSRWHGTLLDRHRPLWEVHLVEGLADGRVAIYFKVHHAL
Mb3761c|M.bovis_AF2122/97 SPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHAL
Rv3734c|M.tuberculosis_H37Rv SPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHAL
MMAR_5271|M.marinum_M SPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLSDGRFAMYAKMHHAL
MAV_0355|M.avium_104 SPRRVRELLELTSRWHSSLLDRHRPLWETHIVEGLKDGRFAIYTKVHHAL
MUL_2057|M.ulcerans_Agy99 RPGRVRELLELTSRLHGSLLDRHRPLWEAHLVEGLNDGRYAVYIKFHHSL
MAB_4544c|M.abscessus_ATCC_199 RPARVRELLTVTSRWHSSPLDRHRPLWEMHVVEGLSDGRLAVYTKMHHAV
MLBr_01244|M.leprae_Br4923 DPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQISHAI
* *:: :.. : . :* ** * ::**: ** *: :. *::
Mflv_1058|M.gilvum_PYR-GCK VDGYSAMRMLGRSLSTDPASRDTRMFFNVPSPTRSRRDPG--AAESSNPL
Mvan_5773|M.vanbaalenii_PYR-1 VDGYTAMRMLGRSLSTDPETRDARMFFNVPIPKRSRPTGA--GAQSSNPV
MSMEG_6322|M.smegmatis_MC2_155 IDGVSAMKLVERTLSEDPSDTTVRVPWNLP-RRESSRRA-----GSSSLA
TH_2030|M.thermoresistible__bu IDGVAVMKLMQRTLSTDPGDD-ARVPWNLP-PPRRNP-A-----GPVSRL
Mb3761c|M.bovis_AF2122/97 IDGVSAMKLAQRTLSADPDDAEVRAIWNLPPRPRTRPPS-----DGSSLL
Rv3734c|M.tuberculosis_H37Rv IDGVSAMKLAQRTLSADPDDAEVRAIWNLPPRPRTRPPS-----DGSSLL
MMAR_5271|M.marinum_M IDGVSAAKLMQRTMSADPSDTEVRAMWNLPRPPRPESNG-----GGSSLV
MAV_0355|M.avium_104 IDGVSAQKLMQRALSSDPDDPEIRAPWTLPKRSRKAGP--------SSRL
MUL_2057|M.ulcerans_Agy99 QDGVSAQKLMQRAFSTDPDDDEIRVPWELKPRRRSNP-G-----HRSSPL
MAB_4544c|M.abscessus_ATCC_199 IDGVGALRMMMRSLSDDPDARDCQAVWAPAKRRAKSSIVSTTNTSAIDLV
MLBr_01244|M.leprae_Br4923 TDGVGSVEMFAEMYDLE-RDPPSRPRSPQPIPQDLSRNDLMLQGINHLPV
** .: . . : :
Mflv_1058|M.gilvum_PYR-GCK TATLRALGGVSSAVTGGVSSAVDLTNALVNTQIRRDGENAHIAGSVSAPH
Mvan_5773|M.vanbaalenii_PYR-1 TATLRALGAVGSTVSDGVGSAVDLASALVNTQIRRDGDFGRISGSASAPH
MSMEG_6322|M.smegmatis_MC2_155 RTATGAATSLAALAP----STIRLARAALLEQQ--------LTLPFGAPR
TH_2030|M.thermoresistible__bu RSATGAVGSVAALAP----STLSLARAALLEQR--------LTLPFGAPR
Mb3761c|M.bovis_AF2122/97 DALFKMAGSVVGLAP----STLKLARAALLEQQ--------LTLPFAAPH
Rv3734c|M.tuberculosis_H37Rv DALFKMAGSVVGLAP----STLKLARAALLEQQ--------LTLPFAAPH
MMAR_5271|M.marinum_M GSLVKMAGSVAGLAP----STLKLARAALFEQQ--------LTLPFAAPH
MAV_0355|M.avium_104 SSLVHAAGSVAALAP----STVSLARAALVEQQ--------LTLPFGAPR
MUL_2057|M.ulcerans_Agy99 RLLTETVGATASLAP----SALSLARAALLEQQ--------LTLPFRAPK
MAB_4544c|M.abscessus_ATCC_199 KGAAGAVRQVVSIPP----GLLKYGRHALSDPQ--------LVKPLSAPH
MLBr_01244|M.leprae_Br4923 ALAGGVVGGLSGVAS--VAGRAILRPASTVSGVVGYVRSGIRVLSQAAEP
. . . . *
Mflv_1058|M.gilvum_PYR-GCK SILNARISRNRRFATQQYEFDRLKKLSSQHGATLNDVALAIIGGGLRKFL
Mvan_5773|M.vanbaalenii_PYR-1 SILNARISRNRRFATQQYEFDRLKKLSSQHGATINDVALAIIGGGLRKFL
MSMEG_6322|M.smegmatis_MC2_155 TMFNVKIGGARRVAAQSWPLERLRRIKAVTGATINDIVLAMCAGALRAYL
TH_2030|M.thermoresistible__bu TMFNVRIGGARRVAAQSWPLQRIRRIRQAAGXTLNDVALAMCAGALRQYL
Mb3761c|M.bovis_AF2122/97 SMFNVKVGGARRCAAQSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYL
Rv3734c|M.tuberculosis_H37Rv SMFNVKVGGARRCAAQSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYL
MMAR_5271|M.marinum_M TMFNVKVGGARRCAAQSWSLERIRAVKQAAGVTVNDAVLAMCAGALRYYL
MAV_0355|M.avium_104 TMLNVKIGGARRCAAQSWPLERIKNVKNAAGVTVNDVVLAMCSGALRYYL
MUL_2057|M.ulcerans_Agy99 TMFNVRIGGARRVAAQSWSLDRIKAVKNAADVTVNDVVLAMSAGALRAYL
MAB_4544c|M.abscessus_ATCC_199 TMLNVSIGGARRFAAQTWSMARIKEAGKALGGTVNDVVLAMCGGALRTYL
MLBr_01244|M.leprae_Br4923 SPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRRYH
: : . * : : :: . ::** ** *.** :
Mflv_1058|M.gilvum_PYR-GCK SDFDKLPDRSLIAFLPVNVRPKGD-EGGGNAVGAILAP-MGTDIEDPVER
Mvan_5773|M.vanbaalenii_PYR-1 ADLGELPDRSLIAFLPVNVRPKGD-EGGGNAVGAILAP-MGTDIEDPVER
MSMEG_6322|M.smegmatis_MC2_155 AEQDALPDRPLIAMVPVSMRSEHEADAGGNMVGSILCS-LGTDVEDPADR
TH_2030|M.thermoresistible__bu LEHDALPATPLVAMVPVSLRSADESAGGGNRTGLVLCN-LATDSDDPAER
Mb3761c|M.bovis_AF2122/97 IERNALPDRPLIAMVPVSLRSKEDADAGGNLVGSVLCN-LATHVDDPAQR
Rv3734c|M.tuberculosis_H37Rv IERNALPDRPLIAMVPVSLRSKEDADAGGNLVGSVLCN-LATHVDDPAQR
MMAR_5271|M.marinum_M IEQDALPDAPLIAMVPVSLRSKEQADSGGNMVGSVLCN-LGTNVEDPAQR
MAV_0355|M.avium_104 LEQNALPDTPLIAMVPVSLRTEEEADAGGNLVGAILCN-LATDSDDPAQR
MUL_2057|M.ulcerans_Agy99 IDQHALPDAPLIAMVPVSLRKEGDADRGGNMVGTLLCN-LATNLDDPMKR
MAB_4544c|M.abscessus_ATCC_199 EEQNALPDKPLVAMCPVSIRAEGDQNAG-NSITALLAN-LATDKPDPLER
MLBr_01244|M.leprae_Br4923 -EALGVSISTLPMAVPVNVRTEADVVGSNRFVGVTLAAPLGTN--DPAAR
: :. .* **.:* : . . *. :.*. ** *
Mflv_1058|M.gilvum_PYR-GCK LDTITTATRAAKGQLQSMSPAAIIAYSAALLAPAGSQIAGALTGVQPPWP
Mvan_5773|M.vanbaalenii_PYR-1 LAVITAATRASKAQLQSMSPAAIIAYSAALLAPAGGQIAGALTGVNPPWP
MSMEG_6322|M.smegmatis_MC2_155 LAVIRRSITDNKRVFSELPRLQALALSALLIAPL--GLTTAFPGFVDATA
TH_2030|M.thermoresistible__bu LDRISSSMRSNKRVFSQLPRVQAMALSAAMIAPL--GLG-AVPGVVSSAP
Mb3761c|M.bovis_AF2122/97 IQTISASMDGNKKVLSELPQLQVLALSALNMAPL--TLA-GVPGFLSAVP
Rv3734c|M.tuberculosis_H37Rv IQTISASMDGNKKVLSELPQLQVLALSALNMAPL--TLA-GVPGFLSAVP
MMAR_5271|M.marinum_M IEIISASMRANKKVLADLPRLQVLALSGLNMAPL--TLA-GVPGFLSTVP
MAV_0355|M.avium_104 LLTISESMRSNKKVFSQLPRFQALALSAANLSSL--ALA-AVPGWVSATS
MUL_2057|M.ulcerans_Agy99 LQVISQSMSDNKKVFAQLPRIQQLALSGLLTGGL--VFG-LVPGFVATAP
MAB_4544c|M.abscessus_ATCC_199 FSAIRDSVQAAKSVLSEMTPLQRMLVGALNGAPV--LTG-AVPGLVDRTA
MLBr_01244|M.leprae_Br4923 MQKIRSQMTQRR----DEPAMNIIGS----LAPLMTVLPASVLDFIVDSV
: * : . . : . . .
Mflv_1058|M.gilvum_PYR-GCK YTFNLCVSNVPGPREPLYFNGSRLEATYPVSIPIHGMALNITLQSYADTM
Mvan_5773|M.vanbaalenii_PYR-1 HTFNLCVSNVPGPREPLYFNGSRLEATFPVSIPIHGMALNITLQSYADTM
MSMEG_6322|M.smegmatis_MC2_155 PPFNLVISNVPGPKKPLYWRGARLAGNYPLSIALDGQALNMTVVSNAHNL
TH_2030|M.thermoresistible__bu PPFNLVISNVPGAPEPRYWMGARLAGNYPLSIVLDGQALNITLVTNADNL
Mb3761c|M.bovis_AF2122/97 PPFNIVISNVPGPVDPLYYGTARLDGSYPLSNIPDGQALNITLVNNAGNL
Rv3734c|M.tuberculosis_H37Rv PPFNIVISNVPGPVDPLYYGTARLDGSYPLSNIPDGQALNITLVNNAGNL
MMAR_5271|M.marinum_M PPFNIVISNVPGGAQPLYYGGARLDGSYPLSNIPDGQALNITLVNNADRL
MAV_0355|M.avium_104 PPFNIVISNVPGPTAPLYYGGARLDGNYPLSIVLDGQALNITLASNAGNL
MUL_2057|M.ulcerans_Agy99 PPFNVVISNVPGAPNPLYWRGARLVGNYPLSIALDGQAMNITVTNNADNL
MAB_4544c|M.abscessus_ATCC_199 PAFNVIISNVPGPRTDMFWNGFEMDGCYPASIPIDGVALNITCTSSGSSM
MLBr_01244|M.leprae_Br4923 ASSDVNASNIPAYPGDTYFAGAKILRQYGIGPRP-GVAMMAVLMSRGGFC
. :: **:*. :: .: : . * *: . . .
Mflv_1058|M.gilvum_PYR-GCK NLGFVGCRDRLPHLQRLAVYTGDALAELEAASQI----------------
Mvan_5773|M.vanbaalenii_PYR-1 NLGFVGCRDRLPRLQRLAVYTGDALGELEAASS-----------------
MSMEG_6322|M.smegmatis_MC2_155 DFGLVGCRRSVPHLQRLLGHLETSLKDLETATGA----------------
TH_2030|M.thermoresistible__bu DFGLVGARGSVPHLQRLLGHLEDSLQQLERAVGG----------------
Mb3761c|M.bovis_AF2122/97 DFGLVGCRRSVPHLQRLLAHLESSLKDLEQAVGI----------------
Rv3734c|M.tuberculosis_H37Rv DFGLVGCRRSVPHLQRLLAHLESSLKDLEQAVGI----------------
MMAR_5271|M.marinum_M DFGLVGCRRSVPSLQRLLGHLETSLKDLEQAVGV----------------
MAV_0355|M.avium_104 DFGLVGCRRSVPHLQRLLMHLESSLKDLERAVGE----------------
MUL_2057|M.ulcerans_Agy99 DFGLVGCRRSVPRLQRMLGHLETSLKELERAVGV----------------
MAB_4544c|M.abscessus_ATCC_199 HFGLTGCRTSVPHLQRILAHLEDALTQLEESVA-----------------
MLBr_01244|M.leprae_Br4923 TVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAARSSG
. . * : : .: ::
Mflv_1058|M.gilvum_PYR-GCK ---------
Mvan_5773|M.vanbaalenii_PYR-1 ---------
MSMEG_6322|M.smegmatis_MC2_155 ---------
TH_2030|M.thermoresistible__bu ---------
Mb3761c|M.bovis_AF2122/97 ---------
Rv3734c|M.tuberculosis_H37Rv ---------
MMAR_5271|M.marinum_M ---------
MAV_0355|M.avium_104 ---------
MUL_2057|M.ulcerans_Agy99 ---------
MAB_4544c|M.abscessus_ATCC_199 ---------
MLBr_01244|M.leprae_Br4923 SPAGWLSSS