For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SPIDALFLSAESREHPLHVGALQLFEPPAGAGRGFVRETYQAMLQCREIAPLFRKRPTSLHGALINLGWS TDADVDLGYHARRSALPAPGRVRELLELTSRLHSNLLDRHRPLWETHVIEGLRDGRFAIYSKMHHALVDG VSGLTLMRQPMTTDPIEGKLRTAWSPATQHTAIKRRRGRLQQLGGMLGSVAGLAPSTLRLARSALIEQQL TLPFGAPHTMLNVAVGGARRCAAQSWPLDRVKAVKDAAGVSLNDVVLAMCAGALREYLDDNDALPDTPLV AMVPVSLRTDRDSVGGNMVGAVLCNLATHLDDPADRLNAIHASMRGNKNVLSQLPRAQALAVSLLLLSPA ALNTLPGLAKATPPPFNVCISNVPGAREPLYFNGARMVGNYPMSLVLDGQALNITLTSTADSLDFGVVGC RRSVPHVQRVLSHLETSLKELERAVGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3740c | - | - | 100% (448) | hypothetical protein Rv3740c |
| M. tuberculosis H37Rv | Rv3734c | - | e-162 | 61.42% (451) | hypothetical protein Rv3734c |
| M. tuberculosis H37Rv | Rv0895 | - | 1e-93 | 44.35% (469) | hypothetical protein Rv0895 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3766c | - | 0.0 | 99.78% (448) | hypothetical protein Mb3766c |
| M. gilvum PYR-GCK | Mflv_1058 | - | 8e-90 | 40.72% (469) | hypothetical protein Mflv_1058 |
| M. leprae Br4923 | MLBr_01244 | - | 8e-23 | 27.57% (341) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_4544c | - | 1e-122 | 49.01% (453) | hypothetical protein MAB_4544c |
| M. marinum M | MMAR_5278 | - | 0.0 | 81.29% (449) | hypothetical protein MMAR_5278 |
| M. avium 104 | MAV_0355 | - | 1e-168 | 65.41% (451) | bifunctional wax ester synthase/acyl-coadiacylglycerol |
| M. smegmatis MC2 155 | MSMEG_6322 | - | 1e-158 | 58.89% (450) | bifunctional wax ester synthase/acyl-CoA diacylglycerol |
| M. thermoresistible (build 8) | TH_2030 | - | 1e-158 | 61.25% (449) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4351 | - | 0.0 | 80.85% (449) | hypothetical protein MUL_4351 |
| M. vanbaalenii PYR-1 | Mvan_5773 | - | 5e-83 | 39.48% (466) | hypothetical protein Mvan_5773 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1058|M.gilvum_PYR-GCK MSANSVRLGLQDLM----FIYGETSSSKMHVGGLLPFTPP-ADAPRDYLR
Mvan_5773|M.vanbaalenii_PYR-1 -------------M----FIYGETSSSKMHVAGLLPFTPP-ADAPRDYLR
Rv3740c|M.tuberculosis_H37Rv -------MSPIDAL----FLSAESREHPLHVGALQLFEPP-AGAGRGFVR
Mb3766c|M.bovis_AF2122/97 -------MSPIDAL----FLSAESREHPLHVGALQLFEPP-AGAGRGFVR
MMAR_5278|M.marinum_M ----MELMSPVDAL----FLSAESREHPLHVGALQLFEPP-EGAGRAFVR
MUL_4351|M.ulcerans_Agy99 -------MSPVDAL----FLSAESREHPLHVGALQLFEPP-EGAGRAFVH
MSMEG_6322|M.smegmatis_MC2_155 -MNRMQLMSPTDSM----FLIAESREHPMHVGGLALYDPP-DDAGPEFVR
TH_2030|M.thermoresistible__bu ----MRLISPADSM----FLLAESREHPMHVAGLQLFEPPPGTAGPEFLQ
MAV_0355|M.avium_104 ----MELIMPTDAV----FLLGESREHPMHVGGLQLYQPP-EGAGRNFVR
MAB_4544c|M.abscessus_ATCC_199 ----MPFMPVSDSM----FLIGETREHPFHVGGLQLFKPP-VDAGPDYAE
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTPDWNRFR
: :: . ..: . .
Mflv_1058|M.gilvum_PYR-GCK GMIDEARRQEVVAPWNRRLAYPRLQFSPLHSWVTDEDFDFDYHVRRSALA
Mvan_5773|M.vanbaalenii_PYR-1 RMVDDARRQEVMPPWNRKLAYPRLQFSPLHTWVTDTEFDFDYHVRRSALA
Rv3740c|M.tuberculosis_H37Rv ETYQAMLQCREIAPLFRKRPTSLHGALINLGWSTDADVDLGYHARRSALP
Mb3766c|M.bovis_AF2122/97 ETYQAMLQCREIAPLFRKRPTSLHGALINLGWSTDADVDLGYHARRSALP
MMAR_5278|M.marinum_M ETHQAMLDCREVAPLFRKRPASFQGVLTNLGWSVDDDIDFGFHVRRSALP
MUL_4351|M.ulcerans_Agy99 ETHQAMLDCREVAPLFRKRPASFQGVLTNLGWSVDDDIDFGFHVRRSALP
MSMEG_6322|M.smegmatis_MC2_155 ELYEEMVRHTDFQPVFRKHPATLLGGIANVGWTLDDEVDLDYHLRRSALP
TH_2030|M.thermoresistible__bu GLHQRLAAGRELHPTFRKHPATLFGGIAHLGWAVDDDVDFDYHLRRSALP
MAV_0355|M.avium_104 DFYKQLVAQPDFQPTFRKHPAKFVGGIANLGWSYDADVDVDYHVRRSALP
MAB_4544c|M.abscessus_ATCC_199 VFYEQLMSTTEVSSDFRKRPGQPLAVMGNLTWIVDDEVDWEYHVRRSALP
MLBr_01244|M.leprae_Br4923 SRIEDVSQR---VLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRRVRVP
. *: * * :.: :* ** :.
Mflv_1058|M.gilvum_PYR-GCK SPGDERELGVLVSRLHSNHLDLTRPPWELHVIEGLEGGRFALYMKIHHAL
Mvan_5773|M.vanbaalenii_PYR-1 SPGDERELGILVSRLHSNHLDLTRPPWELHVIEGLEGGRFALYMKIHHAL
Rv3740c|M.tuberculosis_H37Rv APGRVRELLELTSRLHSNLLDRHRPLWETHVIEGLRDGRFAIYSKMHHAL
Mb3766c|M.bovis_AF2122/97 APGRVRELLELTSRLHSNLLDRHRPLWETHVIEGLRDGRFAIYSKMHHAL
MMAR_5278|M.marinum_M APGRVRELLELTSRLHAHLLDRHRPLWETHVIEGLNDGRFAIYSKMHHAL
MUL_4351|M.ulcerans_Agy99 APGRVRELLELTSRLHAHLLDRHRPLWETHVIEGLNDGRFAIYSKMHHAL
MSMEG_6322|M.smegmatis_MC2_155 SPGRPRELLELTSRVHGTLLDRHRPLWEAYLIEGMADGRFAVYTKVHHSL
TH_2030|M.thermoresistible__bu GPGRIRELLDLTSRWHGTLLDRHRPLWEVHLVEGLADGRVAIYFKVHHAL
MAV_0355|M.avium_104 SPRRVRELLELTSRWHSSLLDRHRPLWETHIVEGLKDGRFAIYTKVHHAL
MAB_4544c|M.abscessus_ATCC_199 RPARVRELLTVTSRWHSSPLDRHRPLWEMHVVEGLSDGRLAVYTKMHHAV
MLBr_01244|M.leprae_Br4923 DPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQISHAI
* **: :.. : :* ** * ::**: ** *: :: *::
Mflv_1058|M.gilvum_PYR-GCK VDGYSAMRMLGRSLSTDPASRDTRMFFNVPSPTRSRRDPGAAESSNPLTA
Mvan_5773|M.vanbaalenii_PYR-1 VDGYTAMRMLGRSLSTDPETRDARMFFNVPIPKRSRPTGAGAQSSNPVTA
Rv3740c|M.tuberculosis_H37Rv VDGVSGLTLMRQPMTTDPIEGKLRTAWSPATQHT-AIKRRRG--------
Mb3766c|M.bovis_AF2122/97 VDGVSGLTLMRQPMTTDPIEGKLRTAWSPATQHT-AIKRRRG--------
MMAR_5278|M.marinum_M IDGVSGLALMRRSLPADPADSNFRATWSPAPERPRRVQTRPG--------
MUL_4351|M.ulcerans_Agy99 IDGVSGLALMRRSLPADPADTNFRATWSPAPERPRGVQTRPG--------
MSMEG_6322|M.smegmatis_MC2_155 IDGVSAMKLVERTLSEDPSDTTVRVPWNLPRRESSRRAGSSS--------
TH_2030|M.thermoresistible__bu IDGVAVMKLMQRTLSTDPGDD-ARVPWNLPPPRRNP-AGPVS--------
MAV_0355|M.avium_104 IDGVSAQKLMQRALSSDPDDPEIRAPWTLP--KRSRKAGPSS--------
MAB_4544c|M.abscessus_ATCC_199 IDGVGALRMMMRSLSDDPDARDCQAVWAPAKRRAKSSIVSTTNTSA--ID
MLBr_01244|M.leprae_Br4923 TDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGINHLPVA
** :. . :
Mflv_1058|M.gilvum_PYR-GCK TLRALGGVSSAVTGGVSSAVDLTNALVNTQIRRDGENAHIAGSVSAPHSI
Mvan_5773|M.vanbaalenii_PYR-1 TLRALGAVGSTVSDGVGSAVDLASALVNTQIRRDGDFGRISGSASAPHSI
Rv3740c|M.tuberculosis_H37Rv RLQQLGGMLGSVAGLAPSTLRLARSALIEQQ--------LTLPFGAPHTM
Mb3766c|M.bovis_AF2122/97 RLQQLGGMLGSVAGLAPSTLRLARSALIEQQ--------LTLPFGAPHTM
MMAR_5278|M.marinum_M PLRQLGGMLGSVAGLAPSSLRLARSALLEQQ--------LTLPFATPRTM
MUL_4351|M.ulcerans_Agy99 PLRQLGGMLGSVAGLAPSSLRLARSALLEQQ--------LTLPFATPRTM
MSMEG_6322|M.smegmatis_MC2_155 LARTATGAATSLAALAPSTIRLARAALLEQQ--------LTLPFGAPRTM
TH_2030|M.thermoresistible__bu RLRSATGAVGSVAALAPSTLSLARAALLEQR--------LTLPFGAPRTM
MAV_0355|M.avium_104 RLSSLVHAAGSVAALAPSTVSLARAALVEQQ--------LTLPFGAPRTM
MAB_4544c|M.abscessus_ATCC_199 LVKGAAGAVRQVVSIPPGLLKYGRHALSDPQ--------LVKPLSAPHTM
MLBr_01244|M.leprae_Br4923 LAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQAAEPSPL
: : : : . * .:
Mflv_1058|M.gilvum_PYR-GCK LNARISRNRRFATQQYEFDRLKKLSSQHGATLNDVALAIIGGGLRKFLSD
Mvan_5773|M.vanbaalenii_PYR-1 LNARISRNRRFATQQYEFDRLKKLSSQHGATINDVALAIIGGGLRKFLAD
Rv3740c|M.tuberculosis_H37Rv LNVAVGGARRCAAQSWPLDRVKAVKDAAGVSLNDVVLAMCAGALREYLDD
Mb3766c|M.bovis_AF2122/97 LNVAVGGARRCAAQSWPLDRVKAVKDAAGVSLNDVVLAMCAGALREYLDD
MMAR_5278|M.marinum_M LNVAIGGARRCAAQSWDIDRVETVKNAAGVSLNDVVLAMCAGALRCYLED
MUL_4351|M.ulcerans_Agy99 LNVAIGGARRCAAQSWDIDRVETVKNAAGVSLNDVVLAMCAGALRCYLED
MSMEG_6322|M.smegmatis_MC2_155 FNVKIGGARRVAAQSWPLERLRRIKAVTGATINDIVLAMCAGALRAYLAE
TH_2030|M.thermoresistible__bu FNVRIGGARRVAAQSWPLQRIRRIRQAAGXTLNDVALAMCAGALRQYLLE
MAV_0355|M.avium_104 LNVKIGGARRCAAQSWPLERIKNVKNAAGVTVNDVVLAMCSGALRYYLLE
MAB_4544c|M.abscessus_ATCC_199 LNVSIGGARRFAAQTWSMARIKEAGKALGGTVNDVVLAMCGGALRTYLEE
MLBr_01244|M.leprae_Br4923 LRQRS-LATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRRYHEA
:. * : : :. . ::** ** *.** :
Mflv_1058|M.gilvum_PYR-GCK FDKLPDRSLIAFLPVNVRPKGDE-GGGNAVGAILAPMGTDIEDPVERLDT
Mvan_5773|M.vanbaalenii_PYR-1 LGELPDRSLIAFLPVNVRPKGDE-GGGNAVGAILAPMGTDIEDPVERLAV
Rv3740c|M.tuberculosis_H37Rv NDALPDTPLVAMVPVSLRTDRDS-VGGNMVGAVLCNLATHLDDPADRLNA
Mb3766c|M.bovis_AF2122/97 NDALPDTPLVAMVPVSLRTDRDS-VGGNMVGAVLCNLATHLDDPADRLNA
MMAR_5278|M.marinum_M NDALPDAPLVAMVPVSLRTERDS-VGGNMVGAVLCNLATHLDDPAQRLAV
MUL_4351|M.ulcerans_Agy99 NDALPDAPLVAMVRVSLRTERDS-VGGNMVGAVLCNLATHLDDPAQRLAV
MSMEG_6322|M.smegmatis_MC2_155 QDALPDRPLIAMVPVSMRSEHEADAGGNMVGSILCSLGTDVEDPADRLAV
TH_2030|M.thermoresistible__bu HDALPATPLVAMVPVSLRSADESAGGGNRTGLVLCNLATDSDDPAERLDR
MAV_0355|M.avium_104 QNALPDTPLIAMVPVSLRTEEEADAGGNLVGAILCNLATDSDDPAQRLLT
MAB_4544c|M.abscessus_ATCC_199 QNALPDKPLVAMCPVSIRAEGDQ-NAGNSITALLANLATDKPDPLERFSA
MLBr_01244|M.leprae_Br4923 LG-VSISTLPMAVPVNVRTEADVVGSNRFVGVTLAAPLG-TNDPAARMQK
. :. .* *.:*. : ... *. ** *:
Mflv_1058|M.gilvum_PYR-GCK ITTATRAAKGQLQSMSPAAIIAYSAALLAPAGSQIAGALTGVQPPWPYTF
Mvan_5773|M.vanbaalenii_PYR-1 ITAATRASKAQLQSMSPAAIIAYSAALLAPAGGQIAGALTGVNPPWPHTF
Rv3740c|M.tuberculosis_H37Rv IHASMRGNKNVLSQLPRAQALAVSLLLLSPA--ALN-TLPGLAKATPPPF
Mb3766c|M.bovis_AF2122/97 IHASMRGNKNVLSQLPRAQALAVSLLLLSPA--ALN-TLPGLAKATPPPF
MMAR_5278|M.marinum_M IHASMRDNKKVLAQLPRAQALALSLLLLSPA--ALN-TLPGLSTVTPPPF
MUL_4351|M.ulcerans_Agy99 IHASMRDNKKVLAQLPRAQALALSLLLLSPA--ALN-TLPGLSTVTPPPF
MSMEG_6322|M.smegmatis_MC2_155 IRRSITDNKRVFSELPRLQALALSALLIAPL--GLTTAFPGFVDATAPPF
TH_2030|M.thermoresistible__bu ISSSMRSNKRVFSQLPRVQAMALSAAMIAPL--GLG-AVPGVVSSAPPPF
MAV_0355|M.avium_104 ISESMRSNKKVFSQLPRFQALALSAANLSSL--ALA-AVPGWVSATSPPF
MAB_4544c|M.abscessus_ATCC_199 IRDSVQAAKSVLSEMTPLQRMLVGALNGAPV--LTG-AVPGLVDRTAPAF
MLBr_01244|M.leprae_Br4923 IRSQMTQ-RRDEPAMNIIGSLAPLMTVLPAS-------VLDFIVDSVASS
* : : : .. . . .
Mflv_1058|M.gilvum_PYR-GCK NLCVSNVPGPREPLYFNGSRLEATYPVS----------IPIHGMALNITL
Mvan_5773|M.vanbaalenii_PYR-1 NLCVSNVPGPREPLYFNGSRLEATFPVS----------IPIHGMALNITL
Rv3740c|M.tuberculosis_H37Rv NVCISNVPGAREPLYFNGARMVGNYPMS----------LVLDGQALNITL
Mb3766c|M.bovis_AF2122/97 NVCISNVPGAREPLYFNGARMVGNYPMS----------LVLDGQALNITL
MMAR_5278|M.marinum_M NVCISNVPGVREPRYFNGARLVGNYPLS----------LPINGQALNITL
MUL_4351|M.ulcerans_Agy99 NVCISNVPGVREPRYFNGARLVGNYPLS----------LPINGQALNITL
MSMEG_6322|M.smegmatis_MC2_155 NLVISNVPGPKKPLYWRGARLAGNYPLS----------IALDGQALNMTV
TH_2030|M.thermoresistible__bu NLVISNVPGAPEPRYWMGARLAGNYPLS----------IVLDGQALNITL
MAV_0355|M.avium_104 NIVISNVPGPTAPLYYGGARLDGNYPLS----------IVLDGQALNITL
MAB_4544c|M.abscessus_ATCC_199 NVIISNVPGPRTDMFWNGFEMDGCYPAS----------IPIDGVALNITC
MLBr_01244|M.leprae_Br4923 DVNASNIPAYPGDTYFAGAKILRQYGIGPRPGVAMMAVLMSRGGFCTVTV
:: **:*. :: * .: : . : * .:*
Mflv_1058|M.gilvum_PYR-GCK QSYADTMNLGFVGCRDRLPHLQRLAVYTGDALAELEAASQI---------
Mvan_5773|M.vanbaalenii_PYR-1 QSYADTMNLGFVGCRDRLPRLQRLAVYTGDALGELEAASS----------
Rv3740c|M.tuberculosis_H37Rv TSTADSLDFGVVGCRRSVPHVQRVLSHLETSLKELERAVGL---------
Mb3766c|M.bovis_AF2122/97 TSTADSLDFGVVGCCRSVPHVQRVLSHLETSLKELERAVGL---------
MMAR_5278|M.marinum_M TSTADRLDFGLVGCRSSVPHLQRMLGHLETSLKELERAVGL---------
MUL_4351|M.ulcerans_Agy99 TSTADRLDFGLVGCRSSVPHLQRMLGHLETSLKELERAVGL---------
MSMEG_6322|M.smegmatis_MC2_155 VSNAHNLDFGLVGCRRSVPHLQRLLGHLETSLKDLETATGA---------
TH_2030|M.thermoresistible__bu VTNADNLDFGLVGARGSVPHLQRLLGHLEDSLQQLERAVGG---------
MAV_0355|M.avium_104 ASNAGNLDFGLVGCRRSVPHLQRLLMHLESSLKDLERAVGE---------
MAB_4544c|M.abscessus_ATCC_199 TSSGSSMHFGLTGCRTSVPHLQRILAHLEDALTQLEESVA----------
MLBr_01244|M.leprae_Br4923 RYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAARSSGSPAG
:. . : .:.: . . :
Mflv_1058|M.gilvum_PYR-GCK -----
Mvan_5773|M.vanbaalenii_PYR-1 -----
Rv3740c|M.tuberculosis_H37Rv -----
Mb3766c|M.bovis_AF2122/97 -----
MMAR_5278|M.marinum_M -----
MUL_4351|M.ulcerans_Agy99 -----
MSMEG_6322|M.smegmatis_MC2_155 -----
TH_2030|M.thermoresistible__bu -----
MAV_0355|M.avium_104 -----
MAB_4544c|M.abscessus_ATCC_199 -----
MLBr_01244|M.leprae_Br4923 WLSSS