For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTRRRASSGGIPVATSMWRDAQTVRTYGPA VAKALALRVAGKARSRLTGRHCRKFMQLTDFDPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYA DVREAARNHDTLSSARGVTFSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGL LTQTPADVVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGFRRLRA LFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMISTLFLTLADYPDQLTLL AQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPAGSLVLLAWGAANRDPRQYEDPDVFRADRN PVGHLAFGSGIHLCPGTQLARMEGQAILREIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2268c | cyp128 | - | 100% (489) | PROBABLE CYTOCHROME P450 128 CYP128 |
| M. tuberculosis H37Rv | Rv1256c | cyp130 | 2e-43 | 32.70% (367) | cytochrome P450 130 CYP130 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 6e-43 | 32.10% (405) | cytochrome P450 123 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2291c | cyp128 | 0.0 | 100.00% (489) | cytochrome P450 128 |
| M. gilvum PYR-GCK | Mflv_1321 | - | 7e-52 | 34.43% (395) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-39 | 30.23% (397) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 5e-42 | 30.33% (399) | cytochrome P450 |
| M. marinum M | MMAR_4833 | cyp123B1 | 2e-54 | 35.33% (368) | cytochrome P450 123B1 Cyp123B1 |
| M. avium 104 | MAV_1339 | - | 1e-49 | 33.89% (360) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4887 | - | 2e-46 | 32.07% (396) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3377 | - | 3e-94 | 45.26% (422) | PUTATIVE putative MorD |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 3e-43 | 32.71% (373) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_5481 | - | 1e-48 | 34.90% (361) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4887|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0324|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4833|M.marinum_M --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
MAB_0276|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1321|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5481|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1339|M.avium_104 --------------------------------------------------
Rv2268c|M.tuberculosis_H37Rv MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTRRRASSG
Mb2291c|M.bovis_AF2122/97 MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTRRRASSG
TH_3377|M.thermoresistible__bu MSTT----------LRLVGDAIR-----------MNVAAAVRTRRRGYDG
MSMEG_4887|M.smegmatis_MC2_155 -----------------------------------------MTASATQNV
MUL_0324|M.ulcerans_Agy99 -----------------------------------------MTVTAASDV
MMAR_4833|M.marinum_M --------------------------------------MWQETLMSTVQL
MLBr_02088|M.leprae_Br4923 -------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQML
MAB_0276|M.abscessus_ATCC_1997 ----------------------------------MPITTDPG------TL
Mflv_1321|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_5481|M.vanbaalenii_PYR-1 ----------------------------------------------MSRL
MAV_1339|M.avium_104 ----------------------------------------MQTHPPLRSP
Rv2268c|M.tuberculosis_H37Rv GIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLT
Mb2291c|M.bovis_AF2122/97 GIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLT
TH_3377|M.thermoresistible__bu --------WTGAIN-----------------------------------T
MSMEG_4887|M.smegmatis_MC2_155 YFDPYDVAINA-DPYPTFARLREEAP--LYYNEQFDFYALSRFSDVNKAL
MUL_0324|M.ulcerans_Agy99 YFDPYDVELNA-DPYPMFRRLREEAP--LYYNAQHGFYALSRFADVDRAI
MMAR_4833|M.marinum_M RYDPFDPEIQD-DPYPVYRQLRDDAP--VYHATDTNTWVLSRHADVISAL
MLBr_02088|M.leprae_Br4923 LLRLIDPGTRA-DPFPVYRALIDY---GPMQLPGMPLTVFSSFSDCDEAL
MAB_0276|M.abscessus_ATCC_1997 LLQVLDPANRA-NPYPVYGQLVEQTQAGPVHPPGMDVSVLATFADCNAVL
Mflv_1321|M.gilvum_PYR-GCK PPPLHSPAFYAGDPFPAYRELRATDP--VTWNEEHGFWALLKYEDIRYVS
Mvan_5481|M.vanbaalenii_PYR-1 SNPLHSPAFYAGDPFPVYRELRATDP--VCWNDEHEFWALLKYEDIRYVS
MAV_1339|M.avium_104 SFPLHSPDFYAGNPYPAYRELRATAP--VCWNDVTNFWALLKYEDIRFVS
Rv2268c|M.tuberculosis_H37Rv DFDPFDPAIAA-DPYPHYRELLAGER--VQYNPKRDVYILSRYADVREAA
Mb2291c|M.bovis_AF2122/97 DFDPFDPAIAA-DPYPHYRELLAGER--VQYNPKRDVYILSRYADVREAA
TH_3377|M.thermoresistible__bu DYDPQDPATAA-HPFDAYRALHRGGR--VHYNPRRATFIVARLEDVRAAL
. .*: : * . * .
MSMEG_4887|M.smegmatis_MC2_155 IDHETFSSARGAIVEL----IKADIEIPSG-ALIFEDPPIHTAHRKLLSR
MUL_0324|M.ulcerans_Agy99 VDYQTFSSARGAILEF----IKANIDIPAG-VLVFEDPPVHDVHRKLLSR
MMAR_4833|M.marinum_M LDHHSYSSVDGVFPTP----PGSTFRESLLPMMILMDPPRHDQLRALVSK
MLBr_02088|M.leprae_Br4923 RHPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSK
MAB_0276|M.abscessus_ATCC_1997 RHPQASSDRRKSNIVQRQLAQ--NPNLIARPSFLGLDAPDHTRLRKLASK
Mflv_1321|M.gilvum_PYR-GCK TNPALFSSARGITVPD-----PAIENPVMEGSLIFTDPPRHRRLRKLINS
Mvan_5481|M.vanbaalenii_PYR-1 TNPALFSSARGVTVPD-----PALENPVMEGSLIFTDPPRHRQLRKLINS
MAV_1339|M.avium_104 SNPALFTSTRGITIPD-----PQLPNPVQQGSLIFTDPPRHRQLRKLINS
Rv2268c|M.tuberculosis_H37Rv RNHDTLSSARGVTFSR-----------GWLPFLPTSDPPAHTRMRKQLAP
Mb2291c|M.bovis_AF2122/97 RNHDTLSSARGVTFSR-----------GWLPFLPTSDPPAHTRMRKQLAP
TH_3377|M.thermoresistible__bu RDTDQVTSCQGVTRWR-----------MSAPLAVLTDGEEHARLRKQVQP
. :. * * *
MSMEG_4887|M.smegmatis_MC2_155 MFTPRKINALEPEIRRFCAQSLDAVAGVE-RFDIIKDFGAIMPMRVISAL
MUL_0324|M.ulcerans_Agy99 MFTPRKINDLEPKIREFCARSLDPLIGSG-RFDFVADLGAQMPMRVIGML
MMAR_4833|M.marinum_M AFTPRRIAALTSAIEDLADHLTGGLIQEAGSADFVADFAAVLPAMVIADL
MLBr_02088|M.leprae_Br4923 AFAPKVVQALEGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRL
MAB_0276|M.abscessus_ATCC_1997 AFAPRVINAMAEDIQTFVDKMLDDIALRG-TFNLVTEFAYPLPVAVICRM
Mflv_1321|M.gilvum_PYR-GCK GFTRRQVAILEPKLRAFARTALDAIDPAG-GTEFAERIAAPLPTRMIAEL
Mvan_5481|M.vanbaalenii_PYR-1 GFTRRQVAILEPKLRAFARAALDAIDPS--ATEFAEQVAAPLPTRMIAEL
MAV_1339|M.avium_104 GFTRRRVSVLEPKIREIVRGILDGIERGA-VHEFAEQIAAPLPTRMIAEL
Rv2268c|M.tuberculosis_H37Rv GMARGALETWRPMVDQLARELVGGLLTQT-PADVVSTVAAPMPMRAITSV
Mb2291c|M.bovis_AF2122/97 GMARGALETWRPMVDQLARELVGGLLTQT-PADVVSTVAAPMPMRAITSV
TH_3377|M.thermoresistible__bu GFSKGAMESWQEIVEKLAVEHVTDLLANP-GCDVVQRLAIPMPIRLIAGI
:: : : : :. .. :. * :
MSMEG_4887|M.smegmatis_MC2_155 LGIPEEDQEKIRDHGNAQMRT----------EAGKPMKAAEEGLVDGSIF
MUL_0324|M.ulcerans_Agy99 LGVPEEDQEAARDFATAQLRT----------EAGKPMKASADGMVSGDFF
MMAR_4833|M.marinum_M LGVPREDRTQFRQWSNALVQSNP--------THGETGEALAAAAAIYGYF
MLBr_02088|M.leprae_Br4923 LGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYL
MAB_0276|M.abscessus_ATCC_1997 LGVPIEDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYF
Mflv_1321|M.gilvum_PYR-GCK LGAPDEDWEQFRRWSDAAVGMDD---------PDVELDTFTAMGELYQYF
Mvan_5481|M.vanbaalenii_PYR-1 LGAPDEDWEQFRTWSDATVGMDD---------PDVELDTFAAMGELYQYF
MAV_1339|M.avium_104 IGAPPDDWEQFRAWSDAATGTAD---------PEIELDPAVAAGQLYEYF
Rv2268c|M.tuberculosis_H37Rv LGVDGPDEAAFCRLSNQAVRITD----VALSAS--GLISLVQGFAGFRRL
Mb2291c|M.bovis_AF2122/97 LGVDGPDEAAFCRLSNQAVRITD----VALSAS--GLISLVQGFAGFRRL
TH_3377|M.thermoresistible__bu LGVPDTDLDDFRRWSERGVGLME----VKPTAITEAARSAIAMASLCRYL
:* * . :
MSMEG_4887|M.smegmatis_MC2_155 EAYIDWRKD---NPSDDIMTELLNVEFTDEHGVTRNLTREELLIYINVVA
MUL_0324|M.ulcerans_Agy99 AHYIDWRAE---HPSSDIMTELLNAEFEDETGTVRRLRRDELLTYVSVVS
MMAR_4833|M.marinum_M TDFLADRRR---QPRDDLMSALVCAEIDGKH-----LSDDELLGFCLLLL
MLBr_02088|M.leprae_Br4923 EQLVKCRRG---TPGEDLISRLIELDESGDQ-----LTEEEIIATCGLLL
MAB_0276|M.abscessus_ATCC_1997 IDLIASRRR---NLGDDLLSALIQVEEAGDQ-----LTEEEIISTCTLLL
Mflv_1321|M.gilvum_PYR-GCK EKLIALRRNGALRDSDDLLSVLVAAEVDGVR-----LSDQDLLQFCLLLL
Mvan_5481|M.vanbaalenii_PYR-1 EAQIARRRDGTLRDSDDLLSVLVAAEVDGVR-----LTDQDLLQFCLLLL
MAV_1339|M.avium_104 QRLIAARR---ARPRADLLSVLAEAEIDEHR-----LTDEDLLNFAFLLL
Rv2268c|M.tuberculosis_H37Rv RALFTHRRDNGLLRECTVLGKLATHAEQGRLS------DDELFFFAVLLL
Mb2291c|M.bovis_AF2122/97 RALFTHRRDNGLLRECTVLGKLATHAEQGRLS------DDELFFFAVLLL
TH_3377|M.thermoresistible__bu RQQFAHG---GLKGSDTVLGRLLAHNTDGSLT------DQQLLLVAIHLL
. :: * :::: :
MSMEG_4887|M.smegmatis_MC2_155 GAGNETTTRLIGWAAKTLAEHPDQRRQLVENPALIPQAIEEILRFEPPAP
MUL_0324|M.ulcerans_Agy99 GAGNETTTRLIGWAGKVLAEHPDQRRALVEDPSLIPQAVEELLRYEAPAP
MMAR_4833|M.marinum_M IAGHETTSNLLANAAVVLADYRDTRRQLAGDESLLGAAVEELLRYDSPAQ
MLBr_02088|M.leprae_Br4923 VAGHETTVNLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIH
MAB_0276|M.abscessus_ATCC_1997 IAGHETTVNLIANASLAMLRHPEQWKLLGQNADRAPLVVEETLRYDPPVH
Mflv_1321|M.gilvum_PYR-GCK VAGNETTRNLIALGTLALIEHPQQFRLLREHPELIPTAVEEFLRYTSPVA
Mvan_5481|M.vanbaalenii_PYR-1 VAGNETTRNLVALGTLALIENPDQFRLLRQRRDLVPTAVEEMLRYASPVA
MAV_1339|M.avium_104 VAGNETTRNLIALGTLALIAHPDQYRLLVEEPARIPLAVEEMLRWNSPVV
Rv2268c|M.tuberculosis_H37Rv VAGYESTAHMISTLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQ
Mb2291c|M.bovis_AF2122/97 VAGYESTAHMISTLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQ
TH_3377|M.thermoresistible__bu IAGNETTTNLLGGMFDTLAHRPDQYQLIRANPELIPIAVEEHLRFTTPIQ
** *:* .::. .: . : .:** **: ..
MSMEG_4887|M.smegmatis_MC2_155 HVARYVTRDVEYHGRTVPEGSVMMLLIGAAVRDSRQFPPDGEVFDINRAP
MUL_0324|M.ulcerans_Agy99 HVARYVTRDLRYYGQSVPEGSIMMMLIGAANRDHRQFRPDGDVFNIRREP
MMAR_4833|M.marinum_M GLSRTLTRDVTVHGVRMSAGESVLLLFGSANRDERVFA-DPDVFDIGRKP
MLBr_02088|M.leprae_Br4923 LIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPS
MAB_0276|M.abscessus_ATCC_1997 MVARVADGEMAIRDFILPDGEWVLLMLAAAQRDPDVGP-DLDVFNPDRSE
Mflv_1321|M.gilvum_PYR-GCK NMTRCATRDVEMRGRLIREGQYVTMLYGSANRDEDIFGPTSEQLDVTRNP
Mvan_5481|M.vanbaalenii_PYR-1 NMTRCATRDVDIRGRSIRAGQYVTMLYGSANRDKDVFGPTSEQFDITRNP
MAV_1339|M.avium_104 HMARTATADVEIRGQRIRAGEVVVMLYGSANRDEDVFGPDSEEFDVTRHP
Rv2268c|M.tuberculosis_H37Rv NICRTTRVDYSVGQAVIPAGSLVLLAWGAANRDPRQYE-DPDVFRADRNP
Mb2291c|M.bovis_AF2122/97 NICRTTRVDYSVGQAVIPAGSLVLLAWGAANRDPRQYE-DPDVFRADRNP
TH_3377|M.thermoresistible__bu NLYRYTRTDYRIGDVVIPAGSRVLLSFGAANRDPSVFD-EPDDFRADRDP
: * : : *. : : .:* ** : : *
MSMEG_4887|M.smegmatis_MC2_155 RQHLAFSVGTHFCLGSALARLEGRVALEEILKRFPEWDVDLASAELSPTS
MUL_0324|M.ulcerans_Agy99 HQHLTFSVGTHYCLGSALARLEGRIALEDILKRFPEWDVDLGNAKLSPTS
MMAR_4833|M.marinum_M EHQVAFGRGIHFCLGASLARMEARIALRALLARVPNWEVDLERAQRLRSG
MLBr_02088|M.leprae_Br4923 SRHLAFAVGSHFCLGAALARLEATVTLSAISARFPQVQL-AGELVYKPNV
MAB_0276|M.abscessus_ATCC_1997 IKHLAFGHGPHFCLGAPLARLEARLALSSITARFPGARL-MDEPTYKPNV
Mflv_1321|M.gilvum_PYR-GCK NPHLAFGCGEHSCLGAQLARLEARVLFEELLARFEHIEP-AGEVLRMQAT
Mvan_5481|M.vanbaalenii_PYR-1 NPHLAFGCGEHSCLGAQLARLEARVLFEELLNRFDHIEL-DGDVLRMQAT
MAV_1339|M.avium_104 NPHIAFGCGEHSCVGAQLARLEATVFFEELLRRYPRIEL-VGEVDRMRAT
Rv2268c|M.tuberculosis_H37Rv VGHLAFGSGIHLCPGTQLARMEGQAILREIVANIDRIEV-VEPPTWTTNA
Mb2291c|M.bovis_AF2122/97 VGHLAFGSGIHLCPGTQLARMEGQAILREIVANIDRIEV-VEPPTWTTNA
TH_3377|M.thermoresistible__bu RKHVAFGYGAHMCLGAPLARMEAQAVLRQLVTRVANISP-VGPTRWSTHS
:::*. * * * *: ***:*. : : .
MSMEG_4887|M.smegmatis_MC2_155 TVRGWDSLPVIVR----------------
MUL_0324|M.ulcerans_Agy99 TVRGWESMPAVFD----------------
MMAR_4833|M.marinum_M PIRGYLSLPISWSAN--------------
MLBr_02088|M.leprae_Br4923 AMRGMSALPVQV-----------------
MAB_0276|M.abscessus_ATCC_1997 TLRGLAELPVSIA----------------
Mflv_1321|M.gilvum_PYR-GCK MVPGVRAMPVRLRAATDPRRAKARAG---
Mvan_5481|M.vanbaalenii_PYR-1 MVPGVRQMPVRLSATAAEPRETGTAAVSV
MAV_1339|M.avium_104 MVPGVKRMPVRMGA---------------
Rv2268c|M.tuberculosis_H37Rv NLRGLTRLRVAVTPRVAP-----------
Mb2291c|M.bovis_AF2122/97 NLRGLTRLRVAVTPRVAP-----------
TH_3377|M.thermoresistible__bu SLHGPTRLPIRLTPA--------------
: * :