For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MWQETLMSTVQLRYDPFDPEIQDDPYPVYRQLRDDAPVYHATDTNTWVLSRHADVISALLDHHSYSSVDG VFPTPPGSTFRESLLPMMILMDPPRHDQLRALVSKAFTPRRIAALTSAIEDLADHLTGGLIQEAGSADFV ADFAAVLPAMVIADLLGVPREDRTQFRQWSNALVQSNPTHGETGEALAAAAAIYGYFTDFLADRRRQPRD DLMSALVCAEIDGKHLSDDELLGFCLLLLIAGHETTSNLLANAAVVLADYRDTRRQLAGDESLLGAAVEE LLRYDSPAQGLSRTLTRDVTVHGVRMSAGESVLLLFGSANRDERVFADPDVFDIGRKPEHQVAFGRGIHF CLGASLARMEARIALRALLARVPNWEVDLERAQRLRSGPIRGYLSLPISWSAN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4833 | cyp123B1 | - | 100% (403) | cytochrome P450 123B1 Cyp123B1 |
| M. marinum M | MMAR_4930 | cyp123A3 | 1e-80 | 43.11% (399) | cytochrome P450 123A3 Cyp123A3 |
| M. marinum M | MMAR_4184 | cyp130A4 | 2e-71 | 40.98% (388) | cytochrome P450 130A4 Cyp130A4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 3e-86 | 45.00% (400) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1598 | - | 3e-80 | 42.18% (403) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 3e-86 | 45.00% (400) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-54 | 36.46% (395) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 4e-82 | 42.39% (401) | cytochrome P450 |
| M. avium 104 | MAV_1389 | - | 1e-73 | 39.80% (402) | NikQ protein |
| M. smegmatis MC2 155 | MSMEG_5861 | - | 4e-82 | 42.68% (396) | cytochrome P450 109 |
| M. thermoresistible (build 8) | TH_2506 | - | 4e-85 | 43.67% (403) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0475 | cyp123A3 | 8e-79 | 42.36% (399) | cytochrome P450 123A3 Cyp123A3 |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | 1e-163 | 72.52% (393) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4833|M.marinum_M -------------------------MWQETLMSTVQLRYDPFDPEIQDDP
Mvan_0317|M.vanbaalenii_PYR-1 -------------------------------MVSVQIRYDPFDASILNDP
MAV_1389|M.avium_104 ---------------------------------MTGLYYDPWNREIDADP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
Mflv_1598|M.gilvum_PYR-GCK --------------------------MTT-----SAVRLDPYNYDFHEDP
TH_2506|M.thermoresistible__bu --------------------------MTV-----TELILDPYDYDFHEDP
MUL_0475|M.ulcerans_Agy99 --------------------------MSVHV-GGPELVLDPYDYDFHEDP
MSMEG_5861|M.smegmatis_MC2_155 --------------------------MSLP---TVEPVLDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: **
MMAR_4833|M.marinum_M YPVYRQLRDDAPVYHATDTNTWVLSRHADVISALLDHHSYSSVDGVFPT-
Mvan_0317|M.vanbaalenii_PYR-1 YPTYRLLRDVAPVYRAEESHTWVLSRHADVQAAALDHSTYSSVDGIFPT-
MAV_1389|M.avium_104 YPIYKMLRNEAPLYYNERHDFWGLSRYDDVDAALRDPLRLSSAKGDILD-
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLD-
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLD-
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMD-
Mflv_1598|M.gilvum_PYR-GCK YPYYQRLRDEAPLYRNDELGFWALSRHADVLKGFRNSTTLSNKFGVSLD-
TH_2506|M.thermoresistible__bu YPYYKRLRDEAPLYHNEDLGFWALSRHADVLKGFRNSVNLSNKYGVSLD-
MUL_0475|M.ulcerans_Agy99 YPYYRRLRNEAPLYHNQELGFWALSRRRDVHQGFRNSTTLSNRDGVSLD-
MSMEG_5861|M.smegmatis_MC2_155 YPYYKRLRDEAPLYRNDERNFWALSRHEDVLKGFRNSTALSNKHGVSLD-
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
:* *: * : .*: .* * . . *.
MMAR_4833|M.marinum_M ---PPGSTFRESLLPMMILMDPPRHDQLRALVSKAFTPRRIAALTSAIED
Mvan_0317|M.vanbaalenii_PYR-1 ---PPGSDFIGSFLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQGTITQ
MAV_1389|M.avium_104 ---VVKADPVMPPG-VFINEDPPLHTIHRALVARAFTPKKMRTLEDKIRA
Mb0789c|M.bovis_AF2122/97 ---PSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv ---PSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ---KASFGPHAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
Mflv_1598|M.gilvum_PYR-GCK ---PASRGPHASKTMSFLAMDDPDHLRLRTLVSKGFTPRRIRELEPRVTE
TH_2506|M.thermoresistible__bu ---PASRGPHASKTMSFLAMDDPEHLRLRTLVSKGFTPRRVRELEPRVTE
MUL_0475|M.ulcerans_Agy99 ---PVSRGPHATKTMSFLAIDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
MSMEG_5861|M.smegmatis_MC2_155 ---PVSRNDEAHRVMSFLALDDPAHLRLRTLVSKGFTPRRIRELEARVTE
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * **::.*:*: : * :
MMAR_4833|M.marinum_M LADHLTGGLIQEAGS---ADFVADFAAVLPAMVIADLLGVPREDRTQFRQ
Mvan_0317|M.vanbaalenii_PYR-1 MAAELFERLDEGSGS---ADFVTDFAAILPAAVIADLLGVPATDRDQFRL
MAV_1389|M.avium_104 FCVASLD-MVADSDR---FDFVEDLGAELPMRTIGMLLGIPDADQPSVRE
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQ-TES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRA
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQ-TES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRA
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALA-NASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIRE
Mflv_1598|M.gilvum_PYR-GCK IANQHLDSMLEAAASGATVDYVDEFAGKLPMDVISELMGVPNADRAQVRA
TH_2506|M.thermoresistible__bu IATQHLDTMLARAGDNETVDYVDEFAGKLPMDVISELMGVPEPDRAQLRA
MUL_0475|M.ulcerans_Agy99 LAVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADRDQIRA
MSMEG_5861|M.smegmatis_MC2_155 IAVQHLEIALQ----SDSFDFVDDFAGKLPMDVISELMGVPEEDRVRIRA
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAG----QFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
: * : : . *. .* *:*:* * .
MMAR_4833|M.marinum_M WSNALVQ-SNPTHGETGE-------ALAAAAAIYGYFTDFLADRRRQPRD
Mvan_0317|M.vanbaalenii_PYR-1 WSSQLVQ-VDVNHGQTTD-------ALAAAAAIYAYFTDFLADRRKNPRE
MAV_1389|M.avium_104 HARATLH-NDT--GGPMP-------IRKDHYFDGDMFSDYVEWRKQNPSD
Mb0789c|M.bovis_AF2122/97 LADAVLHREDGVADVPPP-------AMAASIELMRYYADLIAEFRRRPAN
Rv0766c|M.tuberculosis_H37Rv LADAVLHREDGVADVPPP-------AMAASIELMRYYADLIAEFRRRPAN
MAB_1216c|M.abscessus_ATCC_199 LADGVMHREDGLADVPPE-------AIQASFDLMTYYIEMVRERRRRPTE
Mflv_1598|M.gilvum_PYR-GCK WADAVMHREDGVTDVPDS-------AIEASLNLIVYYQEMVKQRRTALTD
TH_2506|M.thermoresistible__bu WADGVMHREEGVTDVPPA-------AVEASINLIVYYQQMVAERRRKPTD
MUL_0475|M.ulcerans_Agy99 MADGVMHREDGVTDVPAS-------AIEASINLIVYYQQMIAERRKKPSD
MSMEG_5861|M.smegmatis_MC2_155 LADGVMHREDGVADVPAS-------AIAASGELLVYYADMVKRRRRNVSD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
: :: : . : : : :
MMAR_4833|M.marinum_M DLMSALVCAEIDG-----KHLSDDELLGFCLLLLIAGHETTSNLLANAAV
Mvan_0317|M.vanbaalenii_PYR-1 DLMSALANATVDG-----IGLTDEEVLGFCALLLVAGYETTTNLLGNSAV
MAV_1389|M.avium_104 DLITELLSVDFEDQSGTVRRLTTPELLIFLAVIAGAGVETTGRLFGWMGK
Mb0789c|M.bovis_AF2122/97 NLTSALLAAELDG-----DRLSDQEIMAFLFLMVIAGNETTTKLLANAVY
Rv0766c|M.tuberculosis_H37Rv NLTSALLAAELDG-----DRLSDQEIMAFLFLMVIAGNETTTKLLANAVY
MAB_1216c|M.abscessus_ATCC_199 DLTSALLQAEIDG-----DRLTDEEVLAFLFLMVIAGNETTTKLLANAVY
Mflv_1598|M.gilvum_PYR-GCK DLTSALLEAEIDG-----DRLTDDEIIGFMFLMVIAGNETTTKLLANAAF
TH_2506|M.thermoresistible__bu DLTTALLEAEIDG-----DRLTDDEILGFMFLMVIAGNETTTKLLANAMY
MUL_0475|M.ulcerans_Agy99 DLTSALLAADVDG-----DRLTDEEVLGFMFLMVIAGNETTTKLLANAAF
MSMEG_5861|M.smegmatis_MC2_155 DLTSALVEAEIDG-----DKLTDDEIMAFLFLMVVAGNETTTKLLANAAY
MLBr_02088|M.leprae_Br4923 DLISRLIELDESG-----DQLTEEEIIATCGLLLVAGHETTVNLIANAVL
:* : * .. *: *:: :: ** *** .*:.
MMAR_4833|M.marinum_M VLADYRDTRRQLAGDESLLGAAVEELLRYDSPAQGLSRTLTRDVTVHGVR
Mvan_0317|M.vanbaalenii_PYR-1 VLAQHRQTRRRLAADRTLLGPAVEELLRYDSPAQGLSRTLTRDVTLHDTT
MAV_1389|M.avium_104 VLADHPDQRKELAEDRSLIPAAVEELLRYEPPGPSVARYVTEDVEFHGQT
Mb0789c|M.bovis_AF2122/97 WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTT
Rv0766c|M.tuberculosis_H37Rv WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTT
MAB_1216c|M.abscessus_ATCC_199 WGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTK
Mflv_1598|M.gilvum_PYR-GCK WGHRNPDQLGPVFDDHERIPLWVEETLRYDTSSQILARTVIGELELYDTV
TH_2506|M.thermoresistible__bu WAHRNPDQIAPLYDDLDRIPQWVEETLRYDTSSQILARTVVGDLTLYDTR
MUL_0475|M.ulcerans_Agy99 WGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGELTLYDTT
MSMEG_5861|M.smegmatis_MC2_155 WGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTFYGTT
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTT
: : *** ***:.. :.* :: .
MMAR_4833|M.marinum_M MSAGESVLLLFGSANRDERVFADPDVFDIGRKP-EHQVAFGRGIHFCLGA
Mvan_0317|M.vanbaalenii_PYR-1 MRQGEKVLLLFGSANRDERAFPDPDVFDIERTS-EHQVAFGRGIHFCLGA
MAV_1389|M.avium_104 VPSGSAMLLMLSSANRDERRFDHPDRFDIHRKP-GRHLTFGRGVHFCLGA
Mb0789c|M.bovis_AF2122/97 IPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGA
Rv0766c|M.tuberculosis_H37Rv IPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGA
MAB_1216c|M.abscessus_ATCC_199 IPAGDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFGSGAHFCLGA
Mflv_1598|M.gilvum_PYR-GCK LPDGDVVLLLPGSAHRDERVFQNPDDFVIGREIGSKLMSFGSGAHFCLGA
TH_2506|M.thermoresistible__bu IPEGDVVLLLPGSAHRDERVFDDPDRYLIGREIGSKLVSFGSGAHFCLGA
MUL_0475|M.ulcerans_Agy99 IPEGDVVLLLPGSAHRDERAFRDPDEYLIGREIGSKLLSFGSGAHFCLGA
MSMEG_5861|M.smegmatis_MC2_155 VPAGDVLVLLAGSANRDERAFDDPDEYRIGRDIGSKLVSFGSGAHFCLGA
MLBr_02088|M.leprae_Br4923 LTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAVGSHFCLGA
: *. ::*: .:*:** : .* : * : ::*. * ******
MMAR_4833|M.marinum_M SLARMEARIALRALLARVPNWEVDLERAQRLRSGPIRGYLSLPISWSAN-
Mvan_0317|M.vanbaalenii_PYR-1 ALARMEARIALNALLDKVPDWEVDLESARRLRSGPIRGYTSLPITWTTPV
MAV_1389|M.avium_104 PLARLEGRIGLEEVLNRWPEWEIDMDNARRSRTSTVRGWDSMPAIVT---
Mb0789c|M.bovis_AF2122/97 HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199 HLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLRE
Mflv_1598|M.gilvum_PYR-GCK HLARMEARVALAELFKRIRGYEVDEDNAVRVHSSNVRGFAHLPISVKVS-
TH_2506|M.thermoresistible__bu HLARMEARVALTELFKRIRGYEVDEANAVRVHSSNVRGFAHLPITVEVR-
MUL_0475|M.ulcerans_Agy99 HLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA-
MSMEG_5861|M.smegmatis_MC2_155 HLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR-
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAGELVYKPN-VAMRGMSALPVQV----
***:*. : * : : :: : . :** :*
MMAR_4833|M.marinum_M --
Mvan_0317|M.vanbaalenii_PYR-1 --
MAV_1389|M.avium_104 --
Mb0789c|M.bovis_AF2122/97 --
Rv0766c|M.tuberculosis_H37Rv --
MAB_1216c|M.abscessus_ATCC_199 GR
Mflv_1598|M.gilvum_PYR-GCK --
TH_2506|M.thermoresistible__bu --
MUL_0475|M.ulcerans_Agy99 --
MSMEG_5861|M.smegmatis_MC2_155 --
MLBr_02088|M.leprae_Br4923 --