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VTVTAASDVYFDPYDVELNADPYPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAIL EFIKANIDIPAGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIREFCARSLDPLIGSGRFDFVADLGA QMPMRVIGMLLGVPEEDQEAARDFATAQLRTEAGKPMKASADGMVSGDFFAHYIDWRAEHPSSDIMTELL NAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKVLAEHPDQRRALVEDPSLIPQAVEELL RYEAPAPHVARYVTRDLRYYGQSVPEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPHQHLTFSVGTHYC LGSALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | - | 100% (400) | cytochrome P450 189A7 Cyp189A7 |
| M. ulcerans Agy99 | MUL_0475 | cyp123A3 | 6e-63 | 36.66% (401) | cytochrome P450 123A3 Cyp123A3 |
| M. ulcerans Agy99 | MUL_0491 | cyp126A3 | 2e-47 | 32.57% (393) | cytochrome P450 126A3 Cyp126A3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 2e-64 | 37.56% (394) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_2431 | - | 1e-154 | 65.30% (389) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 2e-64 | 37.56% (394) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-44 | 31.66% (398) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 7e-62 | 36.48% (392) | cytochrome P450 |
| M. marinum M | MMAR_4753 | cyp189A7 | 0.0 | 98.75% (400) | cytochrome P450 189A7 Cyp189A7 |
| M. avium 104 | MAV_2984 | - | 1e-176 | 73.87% (398) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_4887 | - | 1e-175 | 71.86% (398) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3021 | - | 1e-172 | 70.78% (397) | PUTATIVE cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4221 | - | 1e-156 | 65.39% (393) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 ------------------MTVRVGDP---------ELVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv ------------------MTVRVGDP---------ELVLDPYDYDFHEDP
MUL_0324|M.ulcerans_Agy99 ------------------MTVTAAS----------DVYFDPYDVELNADP
MMAR_4753|M.marinum_M ------------------MTVTAAS----------DVYFDPYDVELNADP
MAV_2984|M.avium_104 ------------------MTASTDS----------DVRFDPYDVGLIADP
MSMEG_4887|M.smegmatis_MC2_155 ------------------MTASATQ----------NVYFDPYDVAINADP
Mflv_2431|M.gilvum_PYR-GCK ------MSYVRLIQREGAVTISAENSDVHDAET-DELYYDTQSVELNMDP
Mvan_4221|M.vanbaalenii_PYR-1 ------------------MTISADDSDVQNADTAAELYYDPYNVDLNMDP
TH_3021|M.thermoresistible__bu ------------------VTVSAPN----------DVHYDPYDVELNADP
MAB_1406c|M.abscessus_ATCC_199 ------------------MSVDVSHT--------VAPRYVPGTADNWTNP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYR-----NEERNFWAVSRHHDVLQGFRDSTALSNAYG
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYR-----NEERNFWAVSRHHDVLQGFRDSTALSNAYG
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLY-----YNAQHGFYALSRFADVDRAIVDYQTFSSARG
MMAR_4753|M.marinum_M YPMFRRLREEAPLY-----YNAQHGFYALSRFADVDRAIVDYQTFSSARG
MAV_2984|M.avium_104 YPMFARLREEAPLY-----YNAEYDFYAVSRYADVSKALVDHETYSSARG
MSMEG_4887|M.smegmatis_MC2_155 YPTFARLREEAPLY-----YNEQFDFYALSRFSDVNKALIDHETFSSARG
Mflv_2431|M.gilvum_PYR-GCK YAVFARLREEAPLY-----YNAKHDFYALSRYEDVNKAVIDHETFISGRG
Mvan_4221|M.vanbaalenii_PYR-1 HGVFARLREEAPLY-----YNDKHDFYALSRYEDVNKGVIDHQTFISGRG
TH_3021|M.thermoresistible__bu YPMFKRIREEAPLY-----YNPTHDFYALSRFDDVNSAILDHETFSSARG
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSARG
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQ------LPGMPLTVFSSFSDCDEALRHPLSASDRLK
: : : *: ..: . * . . : .
Mb0789c|M.bovis_AF2122/97 VSLD--PSSRTSEA--YRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE
Rv0766c|M.tuberculosis_H37Rv VSLD--PSSRTSEA--YRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE
MUL_0324|M.ulcerans_Agy99 AIL---EFIKANID--IPAGVLVFEDPPVHDVHRKLLSRMFTPRKINDLE
MMAR_4753|M.marinum_M AIL---EIIKANID--IPAGVLVFEDPPVHDVHRKLLSRMFTPRKINDLE
MAV_2984|M.avium_104 AIL---ELIKANLD--IPSGMLIFEDPPIHDVHRKLLSRMFTPRRIAALE
MSMEG_4887|M.smegmatis_MC2_155 AIV---ELIKADIE--IPSGALIFEDPPIHTAHRKLLSRMFTPRKINALE
Mflv_2431|M.gilvum_PYR-GCK ALL---EIIKSGME--IPPGTLIFEDPPIHNIHRNLLSRVFTPRKVLALE
Mvan_4221|M.vanbaalenii_PYR-1 ALL---EIIKSGME--IPPGTLIFEDPPIHNIHRNLLSRVFTPRKVQALE
TH_3021|M.thermoresistible__bu AVL---EIIKSGME--IPPGTLIFEDPPIHNIHRKLLSRMFTPRKIAALE
MAB_1406c|M.abscessus_ATCC_199 LTVTYGDLEKTGMG--DNP-PMVMQDPPTHTEFRKLVSRGFTPRQVTAVE
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
: :: * * * *.*:*: *:*: : :*
Mb0789c|M.bovis_AF2122/97 PQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIR
Rv0766c|M.tuberculosis_H37Rv PQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIR
MUL_0324|M.ulcerans_Agy99 PKIREFCARSLDPLIGSGRFDFVADLGAQMPMRVIGMLLGVPEEDQEAAR
MMAR_4753|M.marinum_M PKIREFCARSLDPLIGSGRFDFVADLGAQMPMRVIGMLLGVPEEDQEAAR
MAV_2984|M.avium_104 PMIRDFCAQCLDPLVGTGHFDFVTDLGAQMPMKVISMLLGIPEDDQEYIR
MSMEG_4887|M.smegmatis_MC2_155 PEIRRFCAQSLDAVAGVERFDIIKDFGAIMPMRVISALLGIPEEDQEKIR
Mflv_2431|M.gilvum_PYR-GCK PQIREFTARCLDPVVGTGKFDFVKDLGNQMPMRVIGMLLGIPEEDQRRVT
Mvan_4221|M.vanbaalenii_PYR-1 PQIREFTARCLDPLTGTNRFDFVRDLGAQMPMRVIGMLLGIPEEDQRRVT
TH_3021|M.thermoresistible__bu PRIREFTARCLDPLVGTGRFDFVQDLGEQMPMRVIGMLLGIPEEDQRHVV
MAB_1406c|M.abscessus_ATCC_199 PKVREFVVQRLERLKERGEGDIVVELFKPLPSMVVAHYLGVPEEDRTQFD
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFG
: : *: *.: :: :. *: :*:* *
Mb0789c|M.bovis_AF2122/97 ALADAVLHREDGVADVPPPAMAASIELMR-------YYADLIAEFRRRPA
Rv0766c|M.tuberculosis_H37Rv ALADAVLHREDGVADVPPPAMAASIELMR-------YYADLIAEFRRRPA
MUL_0324|M.ulcerans_Agy99 DFATAQLRTEAGKPMKASADGMVSG----------DFFAHYIDWRAEHPS
MMAR_4753|M.marinum_M DFATAQLRTEAGKPMKASADGMVSG----------DFFAHYIDWRAEHPS
MAV_2984|M.avium_104 DRGNAQLRTEAGKPMKAAEQGLSVG----------EQFEAYIDWRAEHPS
MSMEG_4887|M.smegmatis_MC2_155 DHGNAQMRTEAGKPMKAAEEGLVDG----------SIFEAYIDWRKDNPS
Mflv_2431|M.gilvum_PYR-GCK DHGEATLQSD-------SVDLMATG----------EVFAEFIDYRTEHPS
Mvan_4221|M.vanbaalenii_PYR-1 DHGEATLQSD-------SVDLMATG----------EVFAEFIDHRTEHPS
TH_3021|M.thermoresistible__bu DHGEATIRTERGG----KMSGLATG----------EVFAEYIDYRAKHPS
MAB_1406c|M.abscessus_ATCC_199 AWTDGIVAAASGGAIDIEAMQGEVAQTIGE---LMMYFTGLIERRRAEPE
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
: : *
Mb0789c|M.bovis_AF2122/97 NNLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAV
Rv0766c|M.tuberculosis_H37Rv NNLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAV
MUL_0324|M.ulcerans_Agy99 SDIMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAG
MMAR_4753|M.marinum_M SDIMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAG
MAV_2984|M.avium_104 DDIMTELLNVEFVDETGTTRRLTREEILVYLNVVAGAGNETTTRLIGWTG
MSMEG_4887|M.smegmatis_MC2_155 DDIMTELLNVEFTDEHGVTRNLTREELLIYINVVAGAGNETTTRLIGWAA
Mflv_2431|M.gilvum_PYR-GCK NDIMTDLLNAEFEDETGTRRKLRREELLMYLTVISTAGSETTTRLIGWAG
Mvan_4221|M.vanbaalenii_PYR-1 DDIMTDLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAG
TH_3021|M.thermoresistible__bu DDIMTELMNAEFEDETGTVRKLGREELLLYLTVIATAGSETTTRLIGWTG
MAB_1406c|M.abscessus_ATCC_199 DDTVSHLVAAGVGADGDISGTLQ---ILGFAFTMVTGGNDTTTGMLGGAI
MLBr_02088|M.leprae_Br4923 EDLISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAV
.: : *: : * :: : .* :**. ::. :
Mb0789c|M.bovis_AF2122/97 YWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDT
Rv0766c|M.tuberculosis_H37Rv YWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDT
MUL_0324|M.ulcerans_Agy99 KVLAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQ
MMAR_4753|M.marinum_M KVLAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGE
MAV_2984|M.avium_104 KVLAEHPDQRRDLVENPALIPQAIEELLRYEPPAPHVSRYVTRDVVVHDQ
MSMEG_4887|M.smegmatis_MC2_155 KTLAEHPDQRRQLVENPALIPQAIEEILRFEPPAPHVARYVTRDVEYHGR
Mflv_2431|M.gilvum_PYR-GCK KTLADYPDQRAELAADHSLIPQAIEEILRWEPPALQIARYVTRDVEYYGQ
Mvan_4221|M.vanbaalenii_PYR-1 KTLADYPEQRAQLVADPALIPQAIEEILRWEPPALQIARYVTRDVEYYGQ
TH_3021|M.thermoresistible__bu KLLSEHPDQRAELVADRSLLPQAIEEILRFEPPAPHMCRYVTRDVEYYGQ
MAB_1406c|M.abscessus_ATCC_199 QLLHQNPAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLARTATRDVIIGDT
MLBr_02088|M.leprae_Br4923 LAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQT
* * : : * :** ** .. : * .::*:
Mb0789c|M.bovis_AF2122/97 TIPEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCL
Rv0766c|M.tuberculosis_H37Rv TIPEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCL
MUL_0324|M.ulcerans_Agy99 SVPEGSIMMMLIGAANRDHRQFRPDGDVFNIRREP-HQHLTFSVGTHYCL
MMAR_4753|M.marinum_M SVPEGSIMMMLIGAANRDHRQFPPDGDVFDIRREP-HQHLTFSVGTHYCL
MAV_2984|M.avium_104 TVPEGSVMMMLIGSACRDEAQFGSDAGEFNIHRAV-RPHLTFSMGTHFCL
MSMEG_4887|M.smegmatis_MC2_155 TVPEGSVMMLLIGAAVRDSRQFPPDGEVFDINRAP-RQHLAFSVGTHFCL
Mflv_2431|M.gilvum_PYR-GCK TVPAGSAMLMLVGSANRDHRRFPPDGDVFDIHREL-RSHMTFGAGTHFCM
Mvan_4221|M.vanbaalenii_PYR-1 VVPEGSAMLMLVGSANRDHRRFPPNGDVFDIHREL-RSHMTFGAGTHFCM
TH_3021|M.thermoresistible__bu TVPAGSAMMLLVGAANRDHRRFPPDGDVFDIHREP-RQHLSFGVGAHFCL
MAB_1406c|M.abscessus_ATCC_199 TIPAGRRALLLYGSANRDEREYGNDAAELDVLRKP-RNILTFSHGNHHCL
MLBr_02088|M.leprae_Br4923 TLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPS-SRHLAFAVGSHFCL
:. * ::* .:* ** : * ::*. * *.*:
Mb0789c|M.bovis_AF2122/97 GAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQA
Rv0766c|M.tuberculosis_H37Rv GAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQA
MUL_0324|M.ulcerans_Agy99 GSALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD-
MMAR_4753|M.marinum_M GSALARLEGRIALEEILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD-
MAV_2984|M.avium_104 GSALARLEGRVALEEILKRFPEWEVDLSRATLSPTSTVRGWECMPALVP-
MSMEG_4887|M.smegmatis_MC2_155 GSALARLEGRVALEEILKRFPEWDVDLASAELSPTSTVRGWDSLPVIVR-
Mflv_2431|M.gilvum_PYR-GCK GNALARLEGRIALEEILKRFPTWEVDWPNAVPSQTTAVRGWETMPTFV--
Mvan_4221|M.vanbaalenii_PYR-1 GNALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS-
TH_3021|M.thermoresistible__bu GNALARLEGRVALDEILNRFPEWEVDMSKAELSPTSTVRGWETMPATIP-
MAB_1406c|M.abscessus_ATCC_199 GAAAARMQSRIALEELLTRIPDFEVDLDGVTWADGSYVRRPLTVPIRVR-
MLBr_02088|M.leprae_Br4923 GAALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV--
* **::. ::* : *: :: :* :* .
Mb0789c|M.bovis_AF2122/97 R
Rv0766c|M.tuberculosis_H37Rv R
MUL_0324|M.ulcerans_Agy99 -
MMAR_4753|M.marinum_M -
MAV_2984|M.avium_104 -
MSMEG_4887|M.smegmatis_MC2_155 -
Mflv_2431|M.gilvum_PYR-GCK -
Mvan_4221|M.vanbaalenii_PYR-1 -
TH_3021|M.thermoresistible__bu -
MAB_1406c|M.abscessus_ATCC_199 -
MLBr_02088|M.leprae_Br4923 -