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MSRLSNPLHSPAFYAGDPFPVYRELRATDPVCWNDEHEFWALLKYEDIRYVSTNPALFSSARGVTVPDPA LENPVMEGSLIFTDPPRHRQLRKLINSGFTRRQVAILEPKLRAFARAALDAIDPSATEFAEQVAAPLPTR MIAELLGAPDEDWEQFRTWSDATVGMDDPDVELDTFAAMGELYQYFEAQIARRRDGTLRDSDDLLSVLVA AEVDGVRLTDQDLLQFCLLLLVAGNETTRNLVALGTLALIENPDQFRLLRQRRDLVPTAVEEMLRYASPV ANMTRCATRDVDIRGRSIRAGQYVTMLYGSANRDKDVFGPTSEQFDITRNPNPHLAFGCGEHSCLGAQLA RLEARVLFEELLNRFDHIELDGDVLRMQATMVPGVRQMPVRLSATAAEPRETGTAAVSV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5481 | - | - | 100% (409) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0246 | - | 1e-73 | 44.10% (390) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | 6e-70 | 41.19% (386) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 1e-64 | 39.17% (360) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_1321 | - | 0.0 | 85.89% (404) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 1e-65 | 40.51% (390) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-46 | 32.65% (392) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1211c | - | 2e-60 | 36.86% (388) | cytochrome P450 |
| M. marinum M | MMAR_4833 | cyp123B1 | 2e-66 | 40.10% (384) | cytochrome P450 123B1 Cyp123B1 |
| M. avium 104 | MAV_1339 | - | 1e-159 | 70.08% (391) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 2e-70 | 41.67% (360) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_2649 | - | 1e-148 | 67.10% (389) | PUTATIVE cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_0491 | cyp126A3 | 2e-65 | 41.04% (402) | cytochrome P450 126A3 Cyp126A3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5481|M.vanbaalenii_PYR-1 ------------------------MSRLSNPLHSPAFY--------AGDP
Mflv_1321|M.gilvum_PYR-GCK ---------------------------MPPPLHSPAFY--------AGDP
MAV_1339|M.avium_104 ------------------MQTHPPLRSPSFPLHSPDFY--------AGNP
TH_2649|M.thermoresistible__bu -------------------------VLTTVPLHSPDFY--------AGNP
Mb2289|M.bovis_AF2122/97 -----------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVR
MSMEG_3551|M.smegmatis_MC2_155 -----------MG----IAPRVNGAAPPDVPLSEINLGSWDFWALDDDIR
MAB_1211c|M.abscessus_ATCC_199 -----------MT---AMKTAAELGLPEGFDFTDPEL-------YGNRMP
MUL_0491|M.ulcerans_Agy99 --------------------MTSAGVLSKIDFTDLDN-------FADGFP
Rv3518c|M.tuberculosis_H37Rv -----------------------MTEAPDVDLADGNFY-------ASREA
MMAR_4833|M.marinum_M ----------------MWQETLMSTVQLRYDPFDPEIQ---------DDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
Mvan_5481|M.vanbaalenii_PYR-1 FPVYRELRATDPVCWN----------DEHEFWALLKYEDIRYVSTNPALF
Mflv_1321|M.gilvum_PYR-GCK FPAYRELRATDPVTWN----------EEHGFWALLKYEDIRYVSTNPALF
MAV_1339|M.avium_104 YPAYRELRATAPVCWN----------DVTNFWALLKYEDIRFVSSNPALF
TH_2649|M.thermoresistible__bu YPAYRELRATTPVVYN----------DVTNFWALLKYEDIRYVSSHPQLF
Mb2289|M.bovis_AF2122/97 DGAFATLRREAPISFWPTIELP-GFVAGNGHWALTKYDDVFYASRHPDIF
MSMEG_3551|M.smegmatis_MC2_155 DGAFATLRREAPISFHPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELF
MAB_1211c|M.abscessus_ATCC_199 HEEFATLRREAPVWWNPQPRTVGGFAD-EGYWVISKHRDVREVSLHTDTF
MUL_0491|M.ulcerans_Agy99 HALFAIHRREAPVYWHEPTDNT---PDGEGFWSVATYPETLEVLRDPVTY
Rv3518c|M.tuberculosis_H37Rv RAAYRWMRANQPVFRD-----------RNGLAAASTYQAVIDAERQPELF
MMAR_4833|M.marinum_M YPVYRQLRDDAPVYHA----------TDTNTWVLSRHADVISALLDHHSY
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLP-----------GMPLTVFSSFSDCDEALRHPLSA
: *: . . .
Mvan_5481|M.vanbaalenii_PYR-1 SSARGVTVP-----DPALENPVMEGSLIFTDPPRHRQLRKLINSGFTRRQ
Mflv_1321|M.gilvum_PYR-GCK SSARGITVP-----DPAIENPVMEGSLIFTDPPRHRRLRKLINSGFTRRQ
MAV_1339|M.avium_104 TSTRGITIP-----DPQLPNPVQQGSLIFTDPPRHRQLRKLINSGFTRRR
TH_2649|M.thermoresistible__bu SSTKGITIP-----DPDQPEPVQEGNLIFTDPPRHRQLRKLINTAFTRRQ
Mb2289|M.bovis_AF2122/97 SSYPNITIN---DQTP--ELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKV
MSMEG_3551|M.smegmatis_MC2_155 SSASGIVIG---DQTP--ELAEYFGSMIAMDDPRHTRLRNIVRSAFTPRV
MAB_1211c|M.abscessus_ATCC_199 SSGRKGAIPRLEDHISPEEFQATLSVLINKDAPEHTQLRGLVSRMFTPRS
MUL_0491|M.ulcerans_Agy99 SSVTGGQRP--FGGTLLQDLAIAGQVLNMMDDPRHAQIRRLVSSGLTPRM
Rv3518c|M.tuberculosis_H37Rv SNAGGIRPD-----------QPALPMMIDMDDPAHLLRRKLVNAGFTRKR
MMAR_4833|M.marinum_M SSVDGVFPTP----PGSTFRESLLPMMILMDPPRHDQLRALVSKAFTPRR
MLBr_02088|M.leprae_Br4923 SDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKV
:. : * * * * :: :: :
Mvan_5481|M.vanbaalenii_PYR-1 VAILEPKLRAFARAALDAIDPS----ATEFAEQVAAPLPTRMIAELLGAP
Mflv_1321|M.gilvum_PYR-GCK VAILEPKLRAFARTALDAIDPAG---GTEFAERIAAPLPTRMIAELLGAP
MAV_1339|M.avium_104 VSVLEPKIREIVRGILDGIERGA---VHEFAEQIAAPLPTRMIAELIGAP
TH_2649|M.thermoresistible__bu VALLEPKVREIVYGIFEGVAPGS---EQEFAESFAAPLPTRMIAELLGAS
Mb2289|M.bovis_AF2122/97 VARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIP
MSMEG_3551|M.smegmatis_MC2_155 LAVIEDSVRDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGIP
MAB_1211c|M.abscessus_ATCC_199 IAALRITLEERAERIVRAALEG---GHGEFVREVASELPMQAIAELIGVP
MUL_0491|M.ulcerans_Agy99 IRRVEDDLRARTRRLLDAVVPG---EPFDFLVDVAAELPMQMICILLGVP
Rv3518c|M.tuberculosis_H37Rv VKDKEASIAALCDTLIDAVCERG---ECDFVRDLAAPLPMAVIGDMLGVR
MMAR_4833|M.marinum_M IAALTSAIEDLADHLTGGLIQEAG--SADFVADFAAVLPAMVIADLLGVP
MLBr_02088|M.leprae_Br4923 VQALEGDIAALVDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVP
: : :. .* *. * ::*
Mvan_5481|M.vanbaalenii_PYR-1 DEDWEQFRTWSDATVGMDDP------DVELDT---FAAMGELYQYFEAQI
Mflv_1321|M.gilvum_PYR-GCK DEDWEQFRRWSDAAVGMDDP------DVELDT---FTAMGELYQYFEKLI
MAV_1339|M.avium_104 PDDWEQFRAWSDAATGTADP------EIELDP---AVAAGQLYEYFQRLI
TH_2649|M.thermoresistible__bu PEDWERFRRWSDACTGTADP------EIELDA---MEAIGELYEYFQQLI
Mb2289|M.bovis_AF2122/97 KADHQRIFHWTNVILGFGDP------DLATDFDEFMQVSADIGAYATALA
MSMEG_3551|M.smegmatis_MC2_155 ESDHQQIFHWTNVILGFGDP------DLTTDFDEFVTVAMDIGAYATALA
MAB_1211c|M.abscessus_ATCC_199 EEDRVKLFEWSNQMTGYDEA------DVEIDP---RVGAAQILGYSYQLA
MUL_0491|M.ulcerans_Agy99 ESERHWLFEAIEPQFDFGGSRKAAV-SQLSVAQTAEEAASRMYSYGQDLI
Rv3518c|M.tuberculosis_H37Rv PEQRDMFLRWSDDLVTFLSS----H-VSQEDFQITMDAFAAYNDFTRATI
MMAR_4833|M.marinum_M REDRTQFRQWSNALVQSNPT--------HGETGEALAAAAAIYGYFTDFL
MLBr_02088|M.leprae_Br4923 YEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLV
: : . :
Mvan_5481|M.vanbaalenii_PYR-1 ARRRDGTLRDSDDLLSVLVAAEVDG---VRLTDQDLLQFCLLLLVAGNET
Mflv_1321|M.gilvum_PYR-GCK ALRRNGALRDSDDLLSVLVAAEVDG---VRLSDQDLLQFCLLLLVAGNET
MAV_1339|M.avium_104 AARR---ARPRADLLSVLAEAEIDE---HRLTDEDLLNFAFLLLVAGNET
TH_2649|M.thermoresistible__bu AARR---TEPRDDMMSVLAQAEVDG---ARLSDEDLLNFAFLLLVAGNET
Mb2289|M.bovis_AF2122/97 EDRR---VNHHDDLTSSLVEAEVDG---ERLSSREIASFFILLVVAGNET
MSMEG_3551|M.smegmatis_MC2_155 DQRR---SAPADDLTTSLVQAEVDG---ERLTSAEVASFFILLVVAGNET
MAB_1211c|M.abscessus_ATCC_199 EQRR---DCPGNDVVSRLLTGTVDG---EQLTPEQFGFFVVMLSVAGNET
MUL_0491|M.ulcerans_Agy99 ASKR---AAPTDDMLSVVANAMVDGGDEPALSDLELYLFFSLLFSAGAET
Rv3518c|M.tuberculosis_H37Rv AARR---ADPTDDLVSVLVSSEVDG---ERLSDDELVMETLLILIGGDET
MMAR_4833|M.marinum_M ADRR---RQPRDDLMSALVCAEIDG---KHLSDDELLGFCLLLLIAGHET
MLBr_02088|M.leprae_Br4923 KCRR---GTPGEDLISRLIELDESG---DQLTEEEIIATCGLLLVAGHET
:* *: : : . *: :. :: .* **
Mvan_5481|M.vanbaalenii_PYR-1 TRNLVALGTLALIENPDQFRLLRQ-RRDLVPTAVEEMLRYASPVANMTRC
Mflv_1321|M.gilvum_PYR-GCK TRNLIALGTLALIEHPQQFRLLRE-HPELIPTAVEEFLRYTSPVANMTRC
MAV_1339|M.avium_104 TRNLIALGTLALIAHPDQYRLLVE-EPARIPLAVEEMLRWNSPVVHMART
TH_2649|M.thermoresistible__bu TRNLIALGTLALIEHPDQCRKLIE-NPTLIPGAVEEMLRYTSPVTHMARQ
Mb2289|M.bovis_AF2122/97 TRNAITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRT
MSMEG_3551|M.smegmatis_MC2_155 TRNAISHGVLALTRYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRT
MAB_1211c|M.abscessus_ATCC_199 TRNATTMGMMAFLEHPGQWELFKS---ARPSTTVDEIVRYTSPLISQQRT
MUL_0491|M.ulcerans_Agy99 TRNAVAGGLLALAEHPEQLRALRG-DLDLLPTAVEEMVRWTSPSPSKRRT
Rv3518c|M.tuberculosis_H37Rv TRHTLSGGTEQLLRNRDQWDLLQR-DPSLLPGAIEEMLRWTAPVKNMCRV
MMAR_4833|M.marinum_M TSNLLANAAVVLADYRDTRRQLAG-DESLLGAAVEELLRYDSPAQGLSRT
MLBr_02088|M.leprae_Br4923 TVNLIANAVLAMLRNPSQWKALSS-NPQRAPLVVEETLRYDPAIHLIGRV
* : : . : .::* :*: .. *
Mvan_5481|M.vanbaalenii_PYR-1 ATRDVDIRGRSIRAGQYVTMLYGSANRDKDVFGPTSEQFDITRNPNPHLA
Mflv_1321|M.gilvum_PYR-GCK ATRDVEMRGRLIREGQYVTMLYGSANRDEDIFGPTSEQLDVTRNPNPHLA
MAV_1339|M.avium_104 ATADVEIRGQRIRAGEVVVMLYGSANRDEDVFGPDSEEFDVTRHPNPHIA
TH_2649|M.thermoresistible__bu ATEDVEIRGRHIRKGDTVVMLYGSANRDEEIFGDDAEDFRIDRQPNPHIA
Mb2289|M.bovis_AF2122/97 LTQDIELRGTKMAAGDKVSLWYCSANRDESKFAD-PWTFDLARNPNPHLG
MSMEG_3551|M.smegmatis_MC2_155 VTRDTELAGTALPAGSKVTLWYGSANRDETKFDN-PWMFDVQRHPNPHVG
MAB_1211c|M.abscessus_ATCC_199 ALQDTVISDVRIRAGERVVMLYPSANFDEEVFEN-PHTFDITRDPNPHLG
MUL_0491|M.ulcerans_Agy99 ATRDVTLAGCSIEAGQKVQIWEGSANRDARIFDH-ADEFDITRKPNPHLG
Rv3518c|M.tuberculosis_H37Rv LTADTEFHGTALCAGEKMMLLFESANFDEAVFCE-PEKFDVQRNPNSHLA
MMAR_4833|M.marinum_M LTRDVTVHGVRMSAGESVLLLFGSANRDERVFAD-PDVFDIGRKPEHQVA
MLBr_02088|M.leprae_Br4923 AAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSR-PDEFDPDRPSSRHLA
* . : *. : : :** * : . : * .. ::.
Mvan_5481|M.vanbaalenii_PYR-1 FG-CGEHSCLGAQLARLEARVLFEELLNRFDHIELDGDV---LRMQATMV
Mflv_1321|M.gilvum_PYR-GCK FG-CGEHSCLGAQLARLEARVLFEELLARFEHIEPAGEV---LRMQATMV
MAV_1339|M.avium_104 FG-CGEHSCVGAQLARLEATVFFEELLRRYPRIELVGEV---DRMRATMV
TH_2649|M.thermoresistible__bu FG-CGEHSCIGAQLARLEACVFFEVLLGRFPDLELVGTV---DRMRATMV
Mb2289|M.bovis_AF2122/97 FGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEP---ARLLSQFI
MSMEG_3551|M.smegmatis_MC2_155 FGGGGAHFCLGANLARREITVLFSELHRHLPDIVATEEP---DRLQSAFI
MAB_1211c|M.abscessus_ATCC_199 FGGTGAHYCLGANLAKAELEIIFNKIADRMPDISRIGDA---PRFHSGWI
MUL_0491|M.ulcerans_Agy99 FG-QGVHYCLGANLARLELRVLFEELLGRFGVVLVGQPV---EWTRSNRH
Rv3518c|M.tuberculosis_H37Rv FG-FGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFV
MMAR_4833|M.marinum_M FG-RGIHFCLGASLARMEARIALRALLARVPNWEVDLER--AQRLRSGPI
MLBr_02088|M.leprae_Br4923 FA-VGSHFCLGAALARLEATVTLSAISARFPQVQLAGEL---VYKPNVAM
*. * * *:* **: * : : :
Mvan_5481|M.vanbaalenii_PYR-1 PGVRQMPVRLSATAAEPRETGTAAVSV
Mflv_1321|M.gilvum_PYR-GCK PGVRAMPVRLRAATDPRRAKARAG---
MAV_1339|M.avium_104 PGVKRMPVRMGA---------------
TH_2649|M.thermoresistible__bu PGVKRMPVRLGAGR-------------
Mb2289|M.bovis_AF2122/97 HGIKTLPVTWS----------------
MSMEG_3551|M.smegmatis_MC2_155 HGIKRLPVAWR----------------
MAB_1211c|M.abscessus_ATCC_199 NGIKKFDTAYCPVTH------------
MUL_0491|M.ulcerans_Agy99 TGIRHLVVELFGG--------------
Rv3518c|M.tuberculosis_H37Rv SGLESMPVVFTPSPPLG----------
MMAR_4833|M.marinum_M RGYLSLPISWSAN--------------
MLBr_02088|M.leprae_Br4923 RGMSALPVQV-----------------
* :