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VTFPMWFAVPPEVPSAWLSTGMGPGPLLAAARAWHALAAQYTEIATELASVLAAVQASSWQGPSADRFVV AHQPFRYWLTHAATVATAAAAAHETAAAGYTSALGGMPTLAELAANHAMHGALVTTNFFGVNTIPIALNE ADYLRMWIQAATVMSHYQAVAHESVAATPSTPPAPQIVTSAASSAASSSFPDPTKLILQLLKDFLELLRY LAVELLPGPLGDLIAQVLDWFISFVSGPVFTFLAYLVLDPLIYFGPFAPLTSPVLLPAGLTGLAGLGAVS GPAGPMVERVHSDGPSRQSWPAATGVTLVGTNPAALVTTPAPAPTTSAAPTAPSTPGSSAAQGLYAVGGP DGEGFNPIAKTTALAGVTTDAAAPAAKLPGDQAQSSASKATRLRRRLRQHRFEFLADDGRLTMPNTPEMA DVAAGNRGLDALGFAGTIPKSAPGSATGLTHLGGGFADVLSQPMLPHTWDGSD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2123 | PPE37 | - | 100% (473) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 3e-80 | 41.16% (498) | PPE family protein |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | 2e-74 | 37.07% (526) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2147 | PPE37 | 0.0 | 97.89% (473) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-79 | 38.43% (523) | PPE protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 2e-58 | 35.45% (488) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 1e-82 | 41.14% (508) | PPE family protein |
| M. marinum M | MMAR_3106 | - | 1e-141 | 55.35% (477) | PPE family protein, PPE37 |
| M. avium 104 | MAV_4872 | - | 7e-81 | 40.76% (498) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-83 | 41.38% (522) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 5e-69 | 46.52% (316) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 6e-80 | 41.45% (509) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-79 | 37.79% (516) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2123|M.tuberculosis_H37Rv ----------MTFPMWFAVPPEVPSAWLSTGMGPGPLLAAARAWHALAAQ
Mb2147|M.bovis_AF2122/97 ----------MTFPMWFAVPPEVPSAWLSTGMGPGPLLAA---------Q
MMAR_3106|M.marinum_M ----------MTFPIWFALPPEVHSTLLSTGPGPSALWSAAAAWRALATQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4872|M.avium_104 ----------MTAPVWMAFAPEVHSTLLSSGPGPAGLLSAAASWTSLSET
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MLBr_01991|M.leprae_Br4923 ----------------MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQ
:* .*** * **:* *. : *
Rv2123|M.tuberculosis_H37Rv YTEIATELASVLAAVQASSWQGPSADRFVVAHQPFRYWLTHAATVATAAA
Mb2147|M.bovis_AF2122/97 YTEIATELASVLAAVQASSWQGPSADRFVVAHQPFRYWLTHAATVATAAA
MMAR_3106|M.marinum_M YTDISDELTQLLAAVRAGSWDGSTAERFVAAHQPFLDWLAQAAAVANAAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4872|M.avium_104 YASAAAELSATLAAAQSDAWQGPSAERYVAAHAPYLAWLERASANSAAVA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MLBr_01991|M.leprae_Br4923 YTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNAITA
*: : **: * .:: * *.:. :: .** .: ** . : *
Rv2123|M.tuberculosis_H37Rv AAHETAAAGYTSALGGMPTLAELAANHAMHGALVTTNFFGVNTIPIALNE
Mb2147|M.bovis_AF2122/97 AAHETAAAGYTSALGGMPTLAELAANHAMHGALVTTNFFGVNTIPIALNE
MMAR_3106|M.marinum_M TAHESAAAGYTSALAAMPTLAELATNHAVHGALVATNFFGINTIPIAFNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4872|M.avium_104 AQQETAAAAYTAALAAMPTLPELAGNHATHAALVATNFFGVNTIPIAVNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MLBr_01991|M.leprae_Br4923 KQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNE
: ** .*: **. ***: ** *:: :. *: ***:*:*:****..*
Rv2123|M.tuberculosis_H37Rv ADYLRMWIQAATVMSHYQAVAHESVAATPSTPPAPQIVTSAASSAASSSF
Mb2147|M.bovis_AF2122/97 ADYLRMWIQAATVMSHYQAVAHESVAATPSTPPAPQIVTSAASSAASISF
MMAR_3106|M.marinum_M SDYMRMWVQAAITMTGYQAVSQHSVTATPRTSPAPQIMTADAAPAATSSM
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MAV_4872|M.avium_104 ADYARMWVQAATTMSTYQAVAGTAVAAAPQTDPAPPIVNSTSSDGS--DS
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
MLBr_01991|M.leprae_Br4923 ADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPGSATQN----
:** ***:*** * **: : : : .* :: . .
Rv2123|M.tuberculosis_H37Rv PD--------------PTKLI-------LQLLKDFLELLRYLAVELLPGP
Mb2147|M.bovis_AF2122/97 PD--------------PTKLI-------LQLLKDFLELLRYLAVELLPGP
MMAR_3106|M.marinum_M PD--------------PVKII-------LQALQGFLNFLRNLAAETLSGP
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVS-NIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLS-NIIADLIRAYGELLRFLFEPIFDFLRDP
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLS-SIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLS-DLIANLLQYYQDYLDQLFGPIVDFLRDP
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSDPWQLLWQLLQYLWNAYTGFNTWMFDLIWEFLQDP
MAV_4872|M.avium_104 DDSGDDGGIVDNDGGNPYQLS-----WWVNRFLEIFQTIGRDLEEFPENP
MAB_4783|M.abscessus_ATCC_1997 QDATKPP-PIVPDPNDPIEML--------LKNSQHFLGMYRALKGLITDP
MLBr_01991|M.leprae_Br4923 ---------------------------VLQSVPDWIVQLLTDILDFIADP
.*
Rv2123|M.tuberculosis_H37Rv LGDLIAQVLDWFIS-----FVSGPVFTFLAYLVLDPLIYFGPFAPLTSP-
Mb2147|M.bovis_AF2122/97 LGDLIAQVLDWFIS-----FVSGPVFTFLAYLVLDPLIYFGPFAPLTSP-
MMAR_3106|M.marinum_M LEKFVVHVLDSFIS-----FASGSVFKFVAYAVLDPMIYFGPFTPAISP-
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLP
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLP
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
TH_3569|M.thermoresistible__bu IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASP
MUL_1208|M.ulcerans_Agy99 IGNTIKIIIAFLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSP
MAV_4872|M.avium_104 SAALTQLLRDIWLLIVDEIGHAIEAFQAFAPQIAAFSLALPAGAAAGLAG
MAB_4783|M.abscessus_ATCC_1997 VGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP-
MLBr_01991|M.leprae_Br4923 YKYFLRFFQRLGFRP------AIAVVLAIIALQLYDFLWYPYYASYGMLL
. . .
Rv2123|M.tuberculosis_H37Rv -VLLPAGLTGLAGLGAVSGP-------AGPMVERVHSDGPSRQSWPAATG
Mb2147|M.bovis_AF2122/97 -VLLPAGLTGLAGLGAVSGP-------AGPMVERVHSDGPSRQSWPAATG
MMAR_3106|M.marinum_M -LGLPAVTVGLAGLACISTPPQT----APPLPGVAQSGPPNHQISPAITG
Mflv_0325|M.gilvum_PYR-GCK LLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPA
Mvan_0415|M.vanbaalenii_PYR-1 LVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAI
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAV
TH_3569|M.thermoresistible__bu VLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------
MUL_1208|M.ulcerans_Agy99 FLLPAALGLALSAIAFTPIQIAA---EVPAAAAPLAAAAVTAKSVFPAAS
MAV_4872|M.avium_104 LSGLAAIQKAAPLPALPAAPPPQ-----PSSMPAVVAGPAMG-----AAA
MAB_4783|M.abscessus_ATCC_1997 -AAGISIPLAITLASLSQMPEAP-----PVDAPAETVPARIDQPHAVAMG
MLBr_01991|M.leprae_Br4923 LPFFAPALSVLGTLSVLWNGQLS-----AGLPPNPAGSHPDNNAGPRIHV
Rv2123|M.tuberculosis_H37Rv VTLVGTNPAALVTTPAPAPTTSAAPTAPSTPGSSAAQGLYAVGGPD-GEG
Mb2147|M.bovis_AF2122/97 VTLVGTNPAALVTTPAPAPTTSAAPTAPSTPGSSAAQGLYAVGGPD-GEG
MMAR_3106|M.marinum_M VAVAGVSSGATVAGATPTAHAAAAPSGPSSAGPVAAQSFYAVLGPD-GGG
Mflv_0325|M.gilvum_PYR-GCK TMSAPPPPSGAPIAANTVSAGSPPAPGA-PAAAAATFVPYVVAGRDPYEG
Mvan_0415|M.vanbaalenii_PYR-1 AVSAPPPPSSAAATVGTVATGTAPAPGA-PAAATASFVPYAVAGRDPGTG
MSMEG_0619|M.smegmatis_MC2_155 GISPAGVPGSAATAAAPAPAPAGTTVAA-PAPAAATFVPYAVANRDPGEG
TH_3569|M.thermoresistible__bu -----------VRAEPQNPLPLTXXX------------------------
MUL_1208|M.ulcerans_Agy99 LASPGTGSAGAPASGAGAGAPGTAPPGP-GAPAPASFLYAVGGSGDWGPS
MAV_4872|M.avium_104 VAAPAPASAGAPAPASATVTASGAAPPP-PSGIGGTAYPYLIGGPTIGSG
MAB_4783|M.abscessus_ATCC_1997 GAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPGFG
MLBr_01991|M.leprae_Br4923 GVAPPASATSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPEV
Rv2123|M.tuberculosis_H37Rv FNPIAKTT--ALAGVTTDAAAPAAKLPGDQAQSSASKATRLRRRLRQHRF
Mb2147|M.bovis_AF2122/97 FNPIAKTT--ALAGVTTDAAAPAAKLPGDQAQSSASKATRLRRRLRQHRF
MMAR_3106|M.marinum_M RTPTTNGK--ALAGATADAVAPAARLPGDQARATSRRARTAQKRLRQYRY
Mflv_0325|M.gilvum_PYR-GCK FSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYAD
Mvan_0415|M.vanbaalenii_PYR-1 FSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYAD
MSMEG_0619|M.smegmatis_MC2_155 FTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYAD
TH_3569|M.thermoresistible__bu --------------------------------------------------
MUL_1208|M.ulcerans_Agy99 LGPTVGGRSGAKAPAVTIPAAGAAAASRASARSRRRRR----TEMRDYGD
MAV_4872|M.avium_104 TG--MGSGAQRKASEPDPAAAAAPAGASASERARARRRRRAAMKDRYRGY
MAB_4783|M.abscessus_ATCC_1997 FGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRH
MLBr_01991|M.leprae_Br4923 SSGPKAGTKSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYRY
Rv2123|M.tuberculosis_H37Rv EFLA---DDG-RLTMPNTPEMADVAAGNRGLDALGFAGTIPKSAPGSATG
Mb2147|M.bovis_AF2122/97 EFLA---DDG-RLTMPNTPEMADVAAGNRGLDALGFAGTIPKSAPGSATG
MMAR_3106|M.marinum_M EFLD---ADG-YPTTVDPPAAEPSAVSEHGANASEFSREISKTIAGQPDR
Mflv_0325|M.gilvum_PYR-GCK AYAD---YEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDE-QAGG
Mvan_0415|M.vanbaalenii_PYR-1 AYAD---YEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAA-QAGG
MSMEG_0619|M.smegmatis_MC2_155 AYMD---YEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDV-TAAG
TH_3569|M.thermoresistible__bu --------------------------------------------------
MUL_1208|M.ulcerans_Agy99 EFLD---MDANGVTGPAAT-DDAARASERGAGQFGFAGTVSTEAVLQAAG
MAV_4872|M.avium_104 EFMD---VEP---DAGPEPETDSVTASDRGAGPLGFAGTAPSAPA-QATG
MAB_4783|M.abscessus_ATCC_1997 EYAT---MDDHTPTGPQDP--VTAVASGTGAGRLGFAGVHTATTAVEATG
MLBr_01991|M.leprae_Br4923 EFVEGTATMADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTAS-----
Rv2123|M.tuberculosis_H37Rv LTHLGGG-FADVLSQPMLPHTWDGSD---------------------
Mb2147|M.bovis_AF2122/97 LTHLGGG-FADVLSQPMLPHTWDGSD---------------------
MMAR_3106|M.marinum_M LTAGRETRFAETTTLPMLPRTWTDADPC-------------------
Mflv_0325|M.gilvum_PYR-GCK LTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 LTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 LTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------------------------------------------
MUL_1208|M.ulcerans_Agy99 LTELAVDEFGNGPRMPMVPGSWDS-----------PQEGREDGLQSE
MAV_4872|M.avium_104 LATLAGDEFGTGPSMPMVPGNWTGE----------------------
MAB_4783|M.abscessus_ATCC_1997 LSTLDGD--AENRTIPMLPGTWDVTDDDR------------------
MLBr_01991|M.leprae_Br4923 --TPTGMAASTSSSVPLLPTTWITGTSETAVHE--------------