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MTFPIWFALPPEVHSTLLSTGPGPSALWSAAAAWRALATQYTDISDELTQLLAAVRAGSWDGSTAERFVA AHQPFLDWLAQAAAVANAAATAHESAAAGYTSALAAMPTLAELATNHAVHGALVATNFFGINTIPIAFNE SDYMRMWVQAAITMTGYQAVSQHSVTATPRTSPAPQIMTADAAPAATSSMPDPVKIILQALQGFLNFLRN LAAETLSGPLEKFVVHVLDSFISFASGSVFKFVAYAVLDPMIYFGPFTPAISPLGLPAVTVGLAGLACIS TPPQTAPPLPGVAQSGPPNHQISPAITGVAVAGVSSGATVAGATPTAHAAAAPSGPSSAGPVAAQSFYAV LGPDGGGRTPTTNGKALAGATADAVAPAARLPGDQARATSRRARTAQKRLRQYRYEFLDADGYPTTVDPP AAEPSAVSEHGANASEFSREISKTIAGQPDRLTAGRETRFAETTTLPMLPRTWTDADPC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3106 | - | - | 100% (479) | PPE family protein, PPE37 |
| M. marinum M | MMAR_0545 | - | 3e-77 | 37.62% (505) | PPE family protein, PPE4 |
| M. marinum M | MMAR_0538 | - | 1e-76 | 36.71% (523) | PPE family protein, PPE3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2147 | PPE37 | 1e-135 | 54.09% (477) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-74 | 36.08% (510) | PPE protein |
| M. tuberculosis H37Rv | Rv2123 | PPE37 | 1e-141 | 55.35% (477) | PPE family protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 2e-62 | 36.63% (486) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-81 | 39.17% (508) | PPE family protein |
| M. avium 104 | MAV_2429 | - | 2e-79 | 36.98% (549) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-79 | 40.15% (518) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-64 | 41.02% (334) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 1e-76 | 37.43% (505) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 6e-77 | 38.61% (518) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
Mb2147|M.bovis_AF2122/97 ----------MTFPMWFAVPPEVPSAWLSTGMGPGPLLAA---------Q
Rv2123|M.tuberculosis_H37Rv ----------MTFPMWFAVPPEVPSAWLSTGMGPGPLLAAARAWHALAAQ
MMAR_3106|M.marinum_M ----------MTFPIWFALPPEVHSTLLSTGPGPSALWSAAAAWRALATQ
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MAV_2429|M.avium_104 ----------MTAPVWIAFPPEVHSTLLSSGPGPAPLLAAATAWSSMSTE
MLBr_01991|M.leprae_Br4923 ----------------MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQ
:* **** * **:* *. .: * :
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
Mb2147|M.bovis_AF2122/97 YTEIATELASVLAAVQASSWQGPSADRFVVAHQPFRYWLTHAATVATAAA
Rv2123|M.tuberculosis_H37Rv YTEIATELASVLAAVQASSWQGPSADRFVVAHQPFRYWLTHAATVATAAA
MMAR_3106|M.marinum_M YTDISDELTQLLAAVRAGSWDGSTAERFVAAHQPFLDWLAQAAAVANAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MAV_2429|M.avium_104 YAAAAAELDGLLAAAHAGAWEGPSAEQYVAAHAPYQAWLLESAAKSSTAA
MLBr_01991|M.leprae_Br4923 YTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNAITA
*: : ** * .:: * *.:. :: .** .: ** . : *
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
Mb2147|M.bovis_AF2122/97 AAHETAAAGYTSALGGMPTLAELAANHAMHGALVTTNFFGVNTIPIALNE
Rv2123|M.tuberculosis_H37Rv AAHETAAAGYTSALGGMPTLAELAANHAMHGALVTTNFFGVNTIPIALNE
MMAR_3106|M.marinum_M TAHESAAAGYTSALAAMPTLAELATNHAVHGALVATNFFGINTIPIAFNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MAV_2429|M.avium_104 SLHETAAGAYTAALAAMPTLGELATNHAVHGALVATNFFGINTIPIAVNE
MLBr_01991|M.leprae_Br4923 KQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNE
: ** .*: **. ***: ** *:: :. *: ***:*:*:****..*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
Mb2147|M.bovis_AF2122/97 ADYLRMWIQAATVMSHYQAVAHESVAATPSTPPAPQIVTS------AASS
Rv2123|M.tuberculosis_H37Rv ADYLRMWIQAATVMSHYQAVAHESVAATPSTPPAPQIVTS------AASS
MMAR_3106|M.marinum_M SDYMRMWVQAAITMTGYQAVSQHSVTATPRTSPAPQIMTA------DAAP
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSP--DSGAAART
MAV_2429|M.avium_104 ADYARMWVQAATTMSTYQAVSQSALAAVPPTTPAPTIVAPGTEAGTATAA
MLBr_01991|M.leprae_Br4923 ADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPG---------
:** ***:*** * **: : : : .* :: .
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVS-NIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLS-NIIADLIRAYGELLRFLFEPIFDFLRDP
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLS-SIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLS-DLIANLLQYYQDYLDQLFGPIVDFLRDP
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSDPWQLLWQLLQYLWNAYTGFNTWMFDLIWEFLQDP
Mb2147|M.bovis_AF2122/97 AASISFPDP----------------TKLILQLLKDFLELLRYLA------
Rv2123|M.tuberculosis_H37Rv AASSSFPDP----------------TKLILQLLKDFLELLRYLA------
MMAR_3106|M.marinum_M AATSSMPDP----------------VKIILQALQGFLNFLRNLA------
MAB_4783|M.abscessus_ATCC_1997 AAQDATKPPPIVP-------DPNDPIEMLLKNSQHFLGMYRALKGLITDP
MAV_2429|M.avium_104 AVQSAAAAPATDSGSNLNHADTSSTQQQASTAAQSYPSWQDQLTAWLKQY
MLBr_01991|M.leprae_Br4923 ----------------------SATQNVLQSVPDWIVQLLTDILDFIADP
:
Mflv_0325|M.gilvum_PYR-GCK IGNTFA-LITDFLTN----PVQALITWGPFLLA-VVYQAVSWVGA--SIL
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIK-LITDFLTN----PAQALITWGPFLAA-VAYQAVSWVGA--SIL
MSMEG_0619|M.smegmatis_MC2_155 LGNLGR-LLTDFMTN----PAGALATWWPFLFG-VAYQVFFNLVG--WPT
TH_3569|M.thermoresistible__bu IGNLFQ-LIDDFLTN----PAGALVTWWPLLFA-VAYQVFTNLVG--WPT
MUL_1208|M.ulcerans_Agy99 IGNTIK-IIIAFLTN----PLQAIITYGPLLFA-LSYQIFFNLVG--WPT
Mb2147|M.bovis_AF2122/97 ---------VELLPG----PLGDLIAQVLDWFISFVSGPVFTFLA-YLVL
Rv2123|M.tuberculosis_H37Rv ---------VELLPG----PLGDLIAQVLDWFISFVSGPVFTFLA-YLVL
MMAR_3106|M.marinum_M ---------AETLSG----PLEKFVVHVLDSFISFASGSVFKFVA-YAVL
MAB_4783|M.abscessus_ATCC_1997 VGTIVR-IIIDFSTN----PAAAIVTWTPLFY-------VFAYAATFAVM
MAV_2429|M.avium_104 TQNFAWPVSKDLNPGGWPFPPVPFVNGLASFFGQLGFSPALSTALGWAIF
MLBr_01991|M.leprae_Br4923 YKYFLRFFQRLGFRP----AIAVVLAIIALQLYDFLWYPYYASYG-----
. .
Mflv_0325|M.gilvum_PYR-GCK YPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSR
Mvan_0415|M.vanbaalenii_PYR-1 YPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTR
MSMEG_0619|M.smegmatis_MC2_155 WGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP
TH_3569|M.thermoresistible__bu WAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP
MUL_1208|M.ulcerans_Agy99 WALILSSPFLLPAALGLALSAIAFTPIQIAA---EVPAAAAPLAAAAVTA
Mb2147|M.bovis_AF2122/97 DPLIYFGPFAPLTSPVLLPAGLTGLAGLGAVSGP---AGPMVERVHSDGP
Rv2123|M.tuberculosis_H37Rv DPLIYFGPFAPLTSPVLLPAGLTGLAGLGAVSGP---AGPMVERVHSDGP
MMAR_3106|M.marinum_M DPMIYFGPFTPAISPLGLPAVTVGLAGLACISTPPQTAPPLPGVAQSGPP
MAB_4783|M.abscessus_ATCC_1997 GTP-IYAAIMGPAAGISIPLAITLASLSQMPEAP--PVDAPAETVPARID
MAV_2429|M.avium_104 HTLMIFWPFMQAAIQMAVVLAPVVVAAIGAAAAGGAAAAVTAISVAAPLS
MLBr_01991|M.leprae_Br4923 ---MLLLPFFAPALSVLGTLSVLWNGQLSAG-----LPPNPAGSHPDNNA
..
Mflv_0325|M.gilvum_PYR-GCK PDQQSFPATMSAPPPPSGAPIAANTVS-----AGSPPAPGAPAAAAATFV
Mvan_0415|M.vanbaalenii_PYR-1 ADQPSPAIAVSAPPPPSSAAATVGTVA-----TGTAPAPGAPAAATASFV
MSMEG_0619|M.smegmatis_MC2_155 RTDQPLAVGISPAGVPGSAATAAAPAP-----APAGTTVAAPAPAAATFV
TH_3569|M.thermoresistible__bu -------------------VRAEPQNP-----LPLTXXX-----------
MUL_1208|M.ulcerans_Agy99 KSVFPAASLASPGTGSAGAPASGAGAG-----APGTAPPGPGAPAPASFL
Mb2147|M.bovis_AF2122/97 SRQSWPAATGVTLVGTNPAALVTTPAP---APTTSAAPTAPSTPGSSAAQ
Rv2123|M.tuberculosis_H37Rv SRQSWPAATGVTLVGTNPAALVTTPAP---APTTSAAPTAPSTPGSSAAQ
MMAR_3106|M.marinum_M NHQISPAITGVAVAGVSSGATVAGATP---TAHAAAAPSGPSSAGPVAAQ
MAB_4783|M.abscessus_ATCC_1997 QPHAVAMGGAPAPTASTAAPTPTTTSP---ATPGSAPAPTPPPAG-AEGL
MAV_2429|M.avium_104 MAAPVPVAAAPAPVATVPAPTIAGAPAGVSHVPTTASAPAPTMAG-SAGG
MLBr_01991|M.leprae_Br4923 GPRIHVGVAPPASATSSGNSYTSNSAP-----STSASATTDNPLSSPSIR
Mflv_0325|M.gilvum_PYR-GCK PYVVAGRDPYEGFSPTVRDST----------------GAKAPAGT-----
Mvan_0415|M.vanbaalenii_PYR-1 PYAVAGRDPGTGFSPTVRDST----------------SAKAPASG-----
MSMEG_0619|M.smegmatis_MC2_155 PYAVANRDPGEGFTPTLGNKS----------------QVAAPASG-----
TH_3569|M.thermoresistible__bu --------------------------------------------------
MUL_1208|M.ulcerans_Agy99 YAVGGSGDWGPSLGPTVGGRS----------------GAKAPAVT-----
Mb2147|M.bovis_AF2122/97 GLYAVGGPDGEGFNPIAKT------------------TALAGVTT-----
Rv2123|M.tuberculosis_H37Rv GLYAVGGPDGEGFNPIAKT------------------TALAGVTT-----
MMAR_3106|M.marinum_M SFYAVLGPDGGGRTPTTNG------------------KALAGATA-----
MAB_4783|M.abscessus_ATCC_1997 GYAVRGDGPGFGFGPTIGASTGA--------------TAHAPSS------
MAV_2429|M.avium_104 G--PVGGGPGVGFGPTATDGIGAGMSDALYAVGLSGLSARGSASSRARRK
MLBr_01991|M.leprae_Br4923 YAIPGLSPPEVSSGPKAGTKS----------------PDTATNTIG----
Mflv_0325|M.gilvum_PYR-GCK ---------IPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYAD---Y
Mvan_0415|M.vanbaalenii_PYR-1 ---------IPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYAD---Y
MSMEG_0619|M.smegmatis_MC2_155 ---------VPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMD---Y
TH_3569|M.thermoresistible__bu --------------------------------------------------
MUL_1208|M.ulcerans_Agy99 ---------IPAAGAAAASRASARSRRRRR----TEMRDYGDEFLD---M
Mb2147|M.bovis_AF2122/97 ---------DAAAPAAKLPGDQAQSSASKATRLRRRLRQHRFEFLA---D
Rv2123|M.tuberculosis_H37Rv ---------DAAAPAAKLPGDQAQSSASKATRLRRRLRQHRFEFLA---D
MMAR_3106|M.marinum_M ---------DAVAPAARLPGDQARATSRRARTAQKRLRQYRYEFLD---A
MAB_4783|M.abscessus_ATCC_1997 ----------AVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYAT---M
MAV_2429|M.avium_104 SEEPAPDDLDAPAAAAAAAAGSKKARARRRRRGTATDRAYRYEYMD---L
MLBr_01991|M.leprae_Br4923 -----------ITAAARTNSPSARAHRKRGNKTRGGARGYRYEFVEGTAT
Mflv_0325|M.gilvum_PYR-GCK EELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDE-QAGGLTTLAGDS
Mvan_0415|M.vanbaalenii_PYR-1 EPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAA-QAGGLTTLPGDP
MSMEG_0619|M.smegmatis_MC2_155 EE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDV-TAAGLTTLTGDT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MUL_1208|M.ulcerans_Agy99 DANGVTGPAAT-DDAARASERGAGQFGFAGTVSTEAVLQAAGLTELAVDE
Mb2147|M.bovis_AF2122/97 DGRLTMP-NTPEMADVAAGNRGLDALGFAGTIPKSAPGSATGLTHLGGG-
Rv2123|M.tuberculosis_H37Rv DGRLTMP-NTPEMADVAAGNRGLDALGFAGTIPKSAPGSATGLTHLGGG-
MMAR_3106|M.marinum_M DGYPTTV-DPPAAEPSAVSEHGANASEFSREISKTIAGQPDRLTAGRETR
MAB_4783|M.abscessus_ATCC_1997 DDHTPTG-PQDP-VTAVASGTGAGRLGFAGVHTATTAVEATGLSTL--DG
MAV_2429|M.avium_104 DTDSGPE-DGGPDDGPVASEASAGQLGFAGAATKSDAARPAGLATLTRDG
MLBr_01991|M.leprae_Br4923 MADTVDAPDHSEPTSHTISNHSAGPIGFAGTVP-------TTASTPTGMA
Mflv_0325|M.gilvum_PYR-GCK FGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 FGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 FDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ---------------------------------------
MUL_1208|M.ulcerans_Agy99 FGNGPRMPMVPGSWDS-----------PQEGREDGLQSE
Mb2147|M.bovis_AF2122/97 FADVLSQPMLPHTWDGSD---------------------
Rv2123|M.tuberculosis_H37Rv FADVLSQPMLPHTWDGSD---------------------
MMAR_3106|M.marinum_M FAETTTLPMLPRTWTDADPC-------------------
MAB_4783|M.abscessus_ATCC_1997 DAENRTIPMLPGTWDVTDDDR------------------
MAV_2429|M.avium_104 SSEGPGVPMMPSTWDRD----------------------
MLBr_01991|M.leprae_Br4923 ASTSSSVPLLPTTWITGTSETAVHE--------------