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FGSVFAGLDESALIAVIEQCAREEAQAGARKSAAIAALVYECVTFDDVRDGWVWDSWAATACELGAALNM GHKRASGQMRIAVALRDRLPRVAALHAQGRLSARLIGQVTWRTRLVQDPHLLALVDAEMAEKALRWEALS DDKLTAALDAVIERYDPDAVIRAREVVKGRDFHIGASDDPDALVTVWGKILGCDAAVLAARIAALLKGIC DNDPRDMGDRRSCAVGAIIHGQDQLSCRCGSPDCTASAPPAPGSSNVVISVLADPAALEAVRRLIASQDR EQQDKLTENTPPGTEPAPESEPAGEAVEPEPQPASEDESPEPTEPEPEAEPEPEPGLEVEAEAAGEAVEP EPQPAGDGASAGPLVPNPLACVRDSGVALLPGVKVLPLVALAEAIRAGAAIKILWLPGPDPEPHYRPSAK LAAFVRARDLFCRYPGCDVPAERCDIDHVVPYPYGPTHPSNLNCKCRTHHLGKTFAEGWQEQQFPDGTVL WTTPAGQRCTTVPGSWLFFPGWDTTTAELPPMAQPPPDPDRLAKMPKRRRTRAADQAARIKAEREHNAIQ RALERQRALERQQAADCNRLAGLPPPVPPAPGYGDDLPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3176 | - | - | 100% (601) | hypothetical protein Mvan_3176 |
| M. vanbaalenii PYR-1 | Mvan_5188 | - | 0.0 | 77.02% (605) | hypothetical protein Mvan_5188 |
| M. vanbaalenii PYR-1 | Mvan_2714 | - | 0.0 | 75.36% (617) | hypothetical protein Mvan_2714 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 1e-118 | 44.65% (551) | hypothetical protein Mb2126 |
| M. gilvum PYR-GCK | Mflv_1272 | - | 0.0 | 65.06% (601) | HNH endonuclease |
| M. tuberculosis H37Rv | Rv3776 | - | 1e-118 | 44.00% (550) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 1e-36 | 37.69% (260) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 3e-43 | 50.00% (194) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 3e-45 | 45.16% (248) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5583 | - | 1e-111 | 40.36% (612) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 1e-37 | 34.08% (267) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 3e-36 | 36.08% (255) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5187|M.marinum_M ------------------------MFESMGVAAGVDHPCDALAERRQLRT
MAV_4456|M.avium_104 ------------------------------MCEDATAWFDELMER-CYPS
MUL_2679|M.ulcerans_Agy99 --------------------------------------MDQHIIEYVFDT
TH_0334|M.thermoresistible__bu ----------------------------------------------MFES
MAB_4752|M.abscessus_ATCC_1997 ----------------------------------------------MFDE
Mvan_3176|M.vanbaalenii_PYR-1 --------------------------------------------MFGSVF
Mflv_1272|M.gilvum_PYR-GCK --------------------------------------------MFDSGL
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv3776|M.tuberculosis_H37Rv --------------------------------------MFEISLSDPVEL
MSMEG_5583|M.smegmatis_MC2_155 ------------------------------MCLLVVPVCDTGCMPFEHTF
MMAR_5187|M.marinum_M PTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWA
MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWA
MUL_2679|M.ulcerans_Agy99 ---DDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWV
TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWA
MAB_4752|M.abscessus_ATCC_1997 --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA
Mvan_3176|M.vanbaalenii_PYR-1 AGLDESALIAVIEQCAREEAQAGARKSAAIAALVYECVTFD--DVRDGWV
Mflv_1272|M.gilvum_PYR-GCK AGLDKPALISAIEQAACEEVRAGARKTAAIAALVHDHVTYD--DVRDEWV
Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTGA---DQRADWA
Rv3776|M.tuberculosis_H37Rv RDADDAALLAAIEDCARAEVAAGARRLSAIAELTSRRTGN---DQRADWA
MSMEG_5583|M.smegmatis_MC2_155 DDLDDAALVAGIEGCERAQNAAAARKLALVARFTARRAADS-EDEVLRWA
. : * : * . . :. : .
MMAR_5187|M.marinum_M VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL
MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF
MUL_2679|M.ulcerans_Agy99 ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF
TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF
MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF
Mvan_3176|M.vanbaalenii_PYR-1 WDSWAATACELGAALNMGHKRASGQMRIAVALRDRLPRVAALHAQGRLSA
Mflv_1272|M.gilvum_PYR-GCK WDSWIETACELGAVLNTSHRRASAQMRIAVALRDRLPGVAALHAQGRLSA
Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLAL-NRLPQVAALFLAGHLGA
Rv3776|M.tuberculosis_H37Rv CDGWDCAAAEVAAALTVSHRKASGQMHLSLTL-NRLPQVAALFLAGQLSA
MSMEG_5583|M.smegmatis_MC2_155 GDDWAATAAEVGAALNVGPAVASKWMRVAQEVGERLPRVQEMFAAGWLSA
* . .*:.* . :: : : .** . * :.
MMAR_5187|M.marinum_M RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA
MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA
MUL_2679|M.ulcerans_Agy99 RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA
TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE
MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL
Mvan_3176|M.vanbaalenii_PYR-1 RLIGQVTWRTRLVQDPHLLALVDAEMAEKALRWEALSDDKLTAALDAVIE
Mflv_1272|M.gilvum_PYR-GCK RLIGQITWRTRLVQDPQALALIDAAIAEKATRWEPLSEDNLTAALDAVIE
Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Rv3776|M.tuberculosis_H37Rv RLVSIIAWRTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWID
MSMEG_5583|M.smegmatis_MC2_155 QVVATLTWATHLVGDEQVLAIVDAQLAARAREFGPMTVDGVKAAVASLLE
: . : : : : :: :** :. : : : : :
MMAR_5187|M.marinum_M RADADAVRRRKERHADREIWIGQDADG--ISRIDGSMFTIDAHALDRRLS
MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLD
MUL_2679|M.ulcerans_Agy99 KFDRDAVRRSRRDAADRYVDCAPLEPG--MALVNRQVFSATAEALARRLD
TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLD
MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLD
Mvan_3176|M.vanbaalenii_PYR-1 RYDPDAVIRAREVVKGRDFHIGASDDPDALVTVWGKILGCDAAVLAARIA
Mflv_1272|M.gilvum_PYR-GCK RFDPDAVIRTREQLKGVDFRIGASDDPDALVTVWGKILGCDAVVLAARIA
Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
Rv3776|M.tuberculosis_H37Rv RYDPAALRRTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLT
MSMEG_5583|M.smegmatis_MC2_155 KYDPAAVRRSREASRDRDVRFGKPDDVTGTVSISGRVNTADAVAYQKRSA
: * .: . . . : : . *
MMAR_5187|M.marinum_M ALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC--AAGARPA
MAV_4456|M.avium_104 ALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC--AAGTRPA
MUL_2679|M.ulcerans_Agy99 ELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP-AAGAPQQ
TH_0334|M.thermoresistible__bu QIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-ADPADTA
MAB_4752|M.abscessus_ATCC_1997 LLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC---SGRDTA
Mvan_3176|M.vanbaalenii_PYR-1 ALLKGICDNDPRDMGDRRSCAVGAIIHGQDQLSCRCGSPDCTASAPPAPG
Mflv_1272|M.gilvum_PYR-GCK ELLKGLCDADPRGIGERRSCAVGAIVRGQDHLPCRCGSPDCAA-APVVPG
Mb2126|M.bovis_AF2122/97 EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
Rv3776|M.tuberculosis_H37Rv QLAHGVCDDDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQ
MSMEG_5583|M.smegmatis_MC2_155 HLTGGVCGDDPRTAGQRRADAFGVIAVQGDRLVCLCGDPQCP-WAGVDPR
: :* *** :**: *...: ::: * ** :*
MMAR_5187|M.marinum_M AQPVVIHVIAERATLDGDGG------------------------------
MAV_4456|M.avium_104 AGPVVIHLIAERASVEGTGG------------------------------
MUL_2679|M.ulcerans_Agy99 PSRVVIHVVAGCQTVDGAGE------------------------------
TH_0334|M.thermoresistible__bu ATRLVINVIAEQATVEGRSD------------------------------
MAB_4752|M.abscessus_ATCC_1997 DVPVVVNVVINQSTLAGSDD------------------------------
Mvan_3176|M.vanbaalenii_PYR-1 SSNVVISVLADPAALEAVRRLIASQDRE------------------QQDK
Mflv_1272|M.gilvum_PYR-GCK SSNVVISVLADPAALEAVRSLIADEDRH------------------QQDA
Mb2126|M.bovis_AF2122/97 AAGVVIHVVADASALDAQPDPHLSG-------------------------
Rv3776|M.tuberculosis_H37Rv ATGVVIHVVADAAALGAAPDPRLSG-------------------------
MSMEG_5583|M.smegmatis_MC2_155 AANTMVHIFAEPSVVDAKPDPYVHGDYASNPVPFVDPEFDPWPVYPERDS
:: :. : .
MMAR_5187|M.marinum_M --------------------------------------------------
MAV_4456|M.avium_104 --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3176|M.vanbaalenii_PYR-1 LTENTPPGTEPAPESEPAGEAVEPEPQPASEDESPEPTEPEPEAEPEPEP
Mflv_1272|M.gilvum_PYR-GCK LAEKQP--------------------------------------------
Mb2126|M.bovis_AF2122/97 ---DEPPSRP----------------------------------------
Rv3776|M.tuberculosis_H37Rv ---PEP--------------------------------------------
MSMEG_5583|M.smegmatis_MC2_155 TPPPEPPSEPQWAPQWWSEIPLPPEPEPEPEPEPEPEPEPEPEPE-----
MMAR_5187|M.marinum_M --------------------------------------------------
MAV_4456|M.avium_104 --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3176|M.vanbaalenii_PYR-1 GLEVEAEAAGEAVEPEPQPAGDGASAGPLVPNPL----------------
Mflv_1272|M.gilvum_PYR-GCK -HAVKAKEQGEPAAPAPSNRGR----------------------------
Mb2126|M.bovis_AF2122/97 --LTPETTLFEALTPDPEPDP-----------------------------
Rv3776|M.tuberculosis_H37Rv -----------ALAP-EAPAT-----------------------------
MSMEG_5583|M.smegmatis_MC2_155 --LRFESEPQTASAPQPEPEPEARPEPQPKTGPEPEPVSTPKPQPQDPPA
MMAR_5187|M.marinum_M ---------------APAWEVGA---------DGLVTPELVAELAKS-AK
MAV_4456|M.avium_104 ---------------GPAVEVGA---------EGLLPAQLVAELAAS-AR
MUL_2679|M.ulcerans_Agy99 ---------------APGVLPG----------DGIIPAEIVRELAKS-AK
TH_0334|M.thermoresistible__bu ---------------NPGYLPG----------YGAVPASILRAKAAT-AT
MAB_4752|M.abscessus_ATCC_1997 ---------------CPAHVPG----------FGVLAAESARAAVAG-TP
Mvan_3176|M.vanbaalenii_PYR-1 -----------ACVRDSGVALLP--------GVKVLPLVALAEAIRAGAA
Mflv_1272|M.gilvum_PYR-GCK ------------CVRDSGTALLP--------GVKILPIVALAEAIRAGAA
Mb2126|M.bovis_AF2122/97 -----------PATHAPAELITT--------GGGVVPAPLLAELIRGGAT
Rv3776|M.tuberculosis_H37Rv -----------PAVKPPAALIS---------GGGVVPAPLLAELIRGGAA
MSMEG_5583|M.smegmatis_MC2_155 AAESWGGGGVNPLVVAPAPVVSPQRATAVIVGGGLVPASYVAQMIASGAK
.. :. :
MMAR_5187|M.marinum_M LVPLRHPGDVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLDHT
MAV_4456|M.avium_104 LMPLVHPADAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATECDLDHT
MUL_2679|M.ulcerans_Agy99 LQPMSTP--ILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVDHT
TH_0334|M.thermoresistible__bu LRPVALP-QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHT
MAB_4752|M.abscessus_ATCC_1997 TRNLTDS----RSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHT
Mvan_3176|M.vanbaalenii_PYR-1 IKILWLPGPD-PEPHYRPSAKLAAFVRARDLFCRYPGCDVPAERCDIDHV
Mflv_1272|M.gilvum_PYR-GCK IKQLWLPGPD-PEPHYRPSAKLAAFVRARDLFCRYPGCNVPAEQCDIDHV
Mb2126|M.bovis_AF2122/97 ISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHS
Rv3776|M.tuberculosis_H37Rv LSRMRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHT
MSMEG_5583|M.smegmatis_MC2_155 VKQGRVPLED-PESGYRPSVGLAEFVRMRDLTCRFPGCGRPAECCDIDHT
. . * ** * *:* ** ** *** : .::**
MMAR_5187|M.marinum_M IPYAQGGPTHASNLKCYCRTHHLVKTFWG-WHDQQLPDGTLILTSPAGHT
MAV_4456|M.avium_104 IPYAEGGPTHASNLKCYCRTHHLVKTFWG-WREQQLPDATLILTSPAGRT
MUL_2679|M.ulcerans_Agy99 IPYSDGGATHPSNLKCLCRKHHLLKTFWG-WHDEQLPDATVIWSLPDGQT
TH_0334|M.thermoresistible__bu IPYPAG-PTHPSNLKLLCVFHCRQAELRF-THDQHKHQSSCLP------A
MAB_4752|M.abscessus_ATCC_1997 VPWATGGPTTGANLKALCRKHHLLKTFGQ-WTELQEPDGTVIWKSPTGHR
Mvan_3176|M.vanbaalenii_PYR-1 VPYPYG-PTHPSNLNCKCRTHHLGKTFAEGWQEQQFPDGTVLWTTPAGQR
Mflv_1272|M.gilvum_PYR-GCK VPWPYG-PTHPSNLNCKCRTHHLGKTFAEGWHEEQLPDGTVIWTTPAGQR
Mb2126|M.bovis_AF2122/97 APWPLG-PTHPSNLKCACRKHHLLKTFWTGWRDVQLPDGTVIWTAPNGHT
Rv3776|M.tuberculosis_H37Rv LPYPLG-PTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIWTAPNGHT
MSMEG_5583|M.smegmatis_MC2_155 EPFPGG-VTHASNIKCLCRFHHLIKTFWAGFVDTQLPDGQVVWTMPSGRT
*:. * * :*:: * * : : : :. :
MMAR_5187|M.marinum_M YVTTPGSALLFPSLCHSTGGLPAAEADPPSDHCDQRSAMMPRRQRTRAQD
MAV_4456|M.avium_104 YVTTPGSALLFPSLCVPTG-EPARPVAAGSQPCGERTAMMPTRRRTRGQN
MUL_2679|M.ulcerans_Agy99 YVTTPGSAWLLPGLFAPSPELPPP----------------PRSEATGSLR
TH_0334|M.thermoresistible__bu YFQRPHG---------------------------------PATRRPPSAR
MAB_4752|M.abscessus_ATCC_1997 YATTPVSWFLFPAL---------------------------TRHHTRQQA
Mvan_3176|M.vanbaalenii_PYR-1 CTTVPGSWLFFPGWDTTTAELPPMAQPPPD---PDRLAKMPKRRRTRAAD
Mflv_1272|M.gilvum_PYR-GCK YSTVPGSRLFFPGWDTTTAELPPMAQPPPD---PDRLAKMPKRRRTRAAD
Mb2126|M.bovis_AF2122/97 YTTHPGSRIFFPTWHTTTAELPQTSTAAVNV--DARGLMMPRRRRTRAAE
Rv3776|M.tuberculosis_H37Rv YTTHPDSRIFLPSWHTTTAALPPAPSPPAIG--PTHTLLMPRRRRTRAAE
MSMEG_5583|M.smegmatis_MC2_155 YTTVPGSRWVFPQWDTTTTTLPPPP-PRATS--PARGVMMPQRKLTRAEQ
* . . .
MMAR_5187|M.marinum_M RARRVATERRQNHHARSTQPGGQPRSAAPP----------TPPQSEPQSH
MAV_4456|M.avium_104 RAARVAAERRANRAARLARATRPAPAASQS----------WPAGHGPDAD
MUL_2679|M.ulcerans_Agy99 KPRRDDAQTRPNSRPKLGR------THCDR----------TQPQHD----
TH_0334|M.thermoresistible__bu GLREAVPRQGVDPRRVSGQ-------------------------------
MAB_4752|M.abscessus_ATCC_1997 RDRRRRTERNLNREQRLQREAALAALAAKD----------PPPF------
Mvan_3176|M.vanbaalenii_PYR-1 QAARIKAEREHNAIQRALER---QRALERQQAADCNRLAGLPPPVPPAPG
Mflv_1272|M.gilvum_PYR-GCK HAARIKAEREDNAHQRALET---ERAAARR--------SGLPPPAP--PD
Mb2126|M.bovis_AF2122/97 LAHRINAERALN-----------DAYMAER---------NKPP------S
Rv3776|M.tuberculosis_H37Rv LAHRIKRERAHVTQRNKPPPSGGDTAVAEG---------FEPPDGVSRLS
MSMEG_5583|M.smegmatis_MC2_155 RARQIRAERARN-----------EKYLSER---------NKPPPQ-----
. .
MMAR_5187|M.marinum_M PPPF----
MAV_4456|M.avium_104 PPPF----
MUL_2679|M.ulcerans_Agy99 --------
TH_0334|M.thermoresistible__bu --------
MAB_4752|M.abscessus_ATCC_1997 --------
Mvan_3176|M.vanbaalenii_PYR-1 YGDDLPPF
Mflv_1272|M.gilvum_PYR-GCK YGDDPPPF
Mb2126|M.bovis_AF2122/97 F-------
Rv3776|M.tuberculosis_H37Rv LSRRVH--
MSMEG_5583|M.smegmatis_MC2_155 --------