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MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVGIGRYTLYAELPRSGGLYRTANVTYRGITIGKVTG VEPTERGARATMSIDNGYQIPTDASANVHSVSAVGEQFVDLVSTRTSGPYLRHGQTITTTTVPSQIGPAL DAANRGLAVLPKDRVASVLHEASEAVGGLGSSLNRLIEATQAIAHDVRGSLEDIDDIIERSAPIIDSQVN SGNEIARWAANLNTLAAQTAQTDPAVRSILANAAPTADQVNATFSDVRESLPQTLANLEVVIDMLKRYHN GVEQALVFLPQSGAIAQSVTTEFPGQAGLGVGGLALNQPPPCLTGFLPASEWRSPADTSTAPLPKGTYCR IPMDASNVVRGARNNPCVDVPGKRAATPRECRSNEAYVPGGTNPWYGDPNQMLSCPAPAARCDQPVKPGQ VIPAPSVNNGINPLPADQLPGTPPPVNDPLQRPGSGTVQCNGQQPNPCVYTPSTFPTTIYDVQSGKVVAP DGVVYSVEASTHAGADGWKVMLAPTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0594 | mce2F | - | 100% (516) | MCE-FAMILY PROTEIN MCE2F |
| M. tuberculosis H37Rv | Rv0174 | mce1F | 0.0 | 69.84% (514) | MCE-family protein MCE1F |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 2e-77 | 39.42% (411) | MCE-family protein MCE3F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0610 | mce2F | 0.0 | 100.00% (516) | MCE-family protein MCE2F |
| M. gilvum PYR-GCK | Mflv_0706 | - | 0.0 | 65.27% (524) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02594 | mce1F | 0.0 | 66.54% (517) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 5e-75 | 33.90% (525) | MCE-family protein |
| M. marinum M | MMAR_0417 | mce1F | 0.0 | 68.98% (519) | MCE-family protein Mce1F |
| M. avium 104 | MAV_4546 | - | 0.0 | 80.67% (507) | mce-family protein mce2f |
| M. smegmatis MC2 155 | MSMEG_0139 | - | 0.0 | 65.51% (519) | mce-family protein mce1f |
| M. thermoresistible (build 8) | TH_2681 | - | 0.0 | 68.34% (518) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1067 | mce1F | 0.0 | 68.79% (519) | MCE-family protein Mce1F |
| M. vanbaalenii PYR-1 | Mvan_0139 | - | 0.0 | 64.50% (524) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0594|M.tuberculosis_H37Rv -MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVGIGRYTLYAELPRS
Mb0610|M.bovis_AF2122/97 -MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVGIGRYTLYAELPRS
MAV_4546|M.avium_104 -----MIKTQLVLLTAVAVAAVVVLGWYYLRIPSLAGIGRYTLYAELPQS
MMAR_0417|M.marinum_M -MLTPFIKRQLIMFGTLTVLSLLVLGVYYLQIPALLGVGRYPLKAELPAS
MUL_1067|M.ulcerans_Agy99 -MLTPFIKRQLIMFGTLTVLSLLVLGVYYLQIPALLGVGRYPLKAELPAS
MLBr_02594|M.leprae_Br4923 -MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVGIGRYSLKAELSAT
Mflv_0706|M.gilvum_PYR-GCK -MLTRFIKIQLIIFTILTVVALGVLGLYYLRLPSLVGVGQYTLYAELPRS
Mvan_0139|M.vanbaalenii_PYR-1 -MLTRFIKFQLITFTILTVVALGVLGLYYLRLPSLAGIGEYKLYAELERS
TH_2681|M.thermoresistible__bu -MLTRFIKMQLVIFTVLTVIALVALGWYYLRVPSLIGIGQYTLHAELPRS
MSMEG_0139|M.smegmatis_MC2_155 MLLTRFIKMQLVIFLTLTLVALVVLALFYLRLPTWAGLGMYKLNADLPNS
MAB_4148c|M.abscessus_ATCC_199 --MERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVAS
*: ** : ::: :: :. ::*::*: *:* : : *:: :
Rv0594|M.tuberculosis_H37Rv GGLYRTANVTYRGITIGKVTGVEPTERGARATMSIDNGYQIPTDASANVH
Mb0610|M.bovis_AF2122/97 GGLYRTANVTYRGITIGKVTGVEPTERGARATMSIDNGYQIPTDASANVH
MAV_4546|M.avium_104 GGLYRTANVTYRGITIGKVTGVEPTERGARATMSIEDGYRIPADAAAHVH
MMAR_0417|M.marinum_M GGLYPTANVTYRGITIGKVTGVEPTATGVEATMSIDSRYKIPVDASANVH
MUL_1067|M.ulcerans_Agy99 GGLYPTANVTYRGITIGKVTGVEPTATGVEATMSIDSRYKIPVDASANVH
MLBr_02594|M.leprae_Br4923 GGLYPTANVTYRGIAIGKVTDVEPTATGAEATMSIDSRYKIPIDSAANVH
Mflv_0706|M.gilvum_PYR-GCK GGLYPTGNVTYRGTQIGKVTEVEPTETGARATMSIDNEYKVPADATANVH
Mvan_0139|M.vanbaalenii_PYR-1 GGLYPTGNVTYRGTQIGKVTEVEPTETGARVTMSIGDEYKIPADVSANVH
TH_2681|M.thermoresistible__bu GGLYATANVTYRGQTIGKVTAVEPTPRGARATMSIGSEYKIPIDSTANVH
MSMEG_0139|M.smegmatis_MC2_155 GGLYATANVTYRGTTIGKVTSVEPSESGARVEMNIYDRYKIPADATANVH
MAB_4148c|M.abscessus_ATCC_199 GGLYQNANVTFRGVQIGRVTDVELTPEGVTATMRLNDNVKVPGNVVAAVK
**** ..***:** **:** ** : *. . * : . ::* : * *:
Rv0594|M.tuberculosis_H37Rv SVSAVGEQFVDLVSTRTSGP-YLRHGQTITTT--TVPSQIGPALDAANRG
Mb0610|M.bovis_AF2122/97 SVSAVGEQFVDLVSTRTSGP-YLRHGQTITTT--TVPSQIGPALDAANRG
MAV_4546|M.avium_104 SVSAVGEQYVDLVSTAGREP-YLVDGQTIHKS--TVPSQIGPALDAANRG
MMAR_0417|M.marinum_M SVSAVGEQYLDLVSTGAPAK-FLSPGQTITKG--TVPSEIGPALDTANRG
MUL_1067|M.ulcerans_Agy99 SVSAVGEQYLDLVSTGAPAK-FLSPGQTITKG--TVPSEIGPALDTANRG
MLBr_02594|M.leprae_Br4923 SVSAVGEQYLDLVSSGNPGK-YLAPGQTITKS--KIPIEIGPALDSVNRG
Mflv_0706|M.gilvum_PYR-GCK SVSAIGEQYLDLVSTSGTTQ-YLSPGQTITEG--TVPSEVGPTIDAANDG
Mvan_0139|M.vanbaalenii_PYR-1 SVSAIGEQYLDLVSETGTDQ-YLSAGQTITKS--TVPAEVGPALDAANNG
TH_2681|M.thermoresistible__bu SVSAIGEQYLDLVPAGTTDV-YFSDGDTITES--TVPSEVGPALDAANEG
MSMEG_0139|M.smegmatis_MC2_155 SVSAVGEQFIDLTSDSGGGA-YFQPGDTITKA--TVPAEVGPALDAAEKG
MAB_4148c|M.abscessus_ATCC_199 SVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQADGL
****:***::** . : *:.* .:* ::.. : .:
Rv0594|M.tuberculosis_H37Rv LAVLPKDRVASVLHEASEAVGGLGSSLNRLIEATQAIAHDVRGSLEDIDD
Mb0610|M.bovis_AF2122/97 LAVLPKDRVASVLHEASEAVGGLGSSLNRLIEATQAIAHDVRGSLEDIDD
MAV_4546|M.avium_104 LAVLPRDKIASLLYETSQAVGGLGPSLRRLVDATQAIAHDFRGSIDHVDD
MMAR_0417|M.marinum_M LEVLPADKIPVLLDETAQAVGGLGPALQRLVDATQAIVGDFHTQINDVND
MUL_1067|M.ulcerans_Agy99 LEVLPADKIPVLLDETAQAVGGLGPALQRLVDATQAIVGDFHTQINDVND
MLBr_02594|M.leprae_Br4923 LAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITDVND
Mflv_0706|M.gilvum_PYR-GCK LAVLPKEKIDALLTETSEAVGGLGPSLQRLVDSTTNLAEGFRDNLPQVTD
Mvan_0139|M.vanbaalenii_PYR-1 LAVLPKEKIDGLLTETSAAVGGLGPALQRLVDSTTNVAEGFRDNLPQVND
TH_2681|M.thermoresistible__bu LQALPAEKIDSLLTETAAAVGGLGPSLQRLVDSTTAIARDFRDNLEPVGD
MSMEG_0139|M.smegmatis_MC2_155 LAVLPKEKIGTLLDEAATAFGGLGPSLQRLVDSTQAIAGDFRANIDPVND
MAB_4148c|M.abscessus_ATCC_199 VNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTK
: .:. :: :* *: *..* * * **:.:: : . . .
Rv0594|M.tuberculosis_H37Rv IIERSAPIIDSQVNSGNEIARWAANLNTLAAQTAQTDPAVRSILANAAPT
Mb0610|M.bovis_AF2122/97 IIERSAPIIDSQVNSGNEIARWAANLNTLAAQTAQTDPAVRSILANAAPT
MAV_4546|M.avium_104 IVERSAPIIDSQADSADTLGRWAANLNTLAAQTARQDPALRSILANAAPT
MMAR_0417|M.marinum_M IIQNSGPILDSQVNSGDAISRWAHNLNVLATQTAERDQNVKSILTQAAPT
MUL_1067|M.ulcerans_Agy99 IIQNSGPILDSQVNSGDAISRWAHNLNVLATQTAERDQNVKSILTQAAPT
MLBr_02594|M.leprae_Br4923 IIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQAAPT
Mflv_0706|M.gilvum_PYR-GCK IINNAAPILDSQVQSGDAIEQWSRNLNVIASQTAEQDAALRSGLQQAAPT
Mvan_0139|M.vanbaalenii_PYR-1 IITNSAPILQSQVTSGDAIEQWSRNLNVIASQTAEQDAALRSGLQQAAPT
TH_2681|M.thermoresistible__bu IIDNSAPILDSQVDSGDAIARWSRNVNILAAQAAQQDAALRSGLQQAAPT
MSMEG_0139|M.smegmatis_MC2_155 IIENSGPIIDSQVNSGDAIQRWAANLNTLAAQSAQNDEALRSGLQQAAPT
MAB_4148c|M.abscessus_ATCC_199 LIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGA
:: . .*::::* * : : .: :: : *. * ::. * *. :
Rv0594|M.tuberculosis_H37Rv ADQVNATFSDVRESLPQTLANLEVVIDMLKRYHNGVEQALVFLPQ--SGA
Mb0610|M.bovis_AF2122/97 ADQVNATFSDVRESLPQTLANLEVVIDMLKRYHNGVEQALVFLPQ--SGA
MAV_4546|M.avium_104 AEQVRATFGGVRESLPQTLANLEVVIDMLKRYHNGVEQALVFLPQ--SGA
MMAR_0417|M.marinum_M ADQLNSVFSDVRDSLPQTLANLEVVFDLLKRYHKGLEQVLVFLPQ--GAS
MUL_1067|M.ulcerans_Agy99 ADQLNSVFSDVRDSLPQTLANLEVVFDLLKRYHKGLEQVLVFLPQ--GAS
MLBr_02594|M.leprae_Br4923 ADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQ--GAS
Mflv_0706|M.gilvum_PYR-GCK LDQVNTVFSDVQEALPQTLANLAVVNDMLKRYNKGIEQTLVIYPQ--GAS
Mvan_0139|M.vanbaalenii_PYR-1 LDQVTTVFSDVRDALPQTLANLAVINDMLKRYNKGIEQTLVIYPQ--GAS
TH_2681|M.thermoresistible__bu ADQLNAVFGGVRESLPQVLANLAVVSDMLKRYHKGLNQSLVILPQ--GAA
MSMEG_0139|M.smegmatis_MC2_155 ADQLNAVFSDVRESLPQTLANLEIVIDMLKRYNKNVEQVLVALPQ--GAA
MAB_4148c|M.abscessus_ATCC_199 SEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALFSAL
:: *..:: ::* *.: : : *::.::* ** * ..
Rv0594|M.tuberculosis_H37Rv IAQSVTTEFPGQAGLGVGGLALNQPPPCLTGFLPASEWRSPADTSTAPLP
Mb0610|M.bovis_AF2122/97 IAQSVTTEFPGQAGLGVGGLALNQPPPCLTGFLPASEWRSPADTSTAPLP
MAV_4546|M.avium_104 IAQSVTAQSPGQAALGVGAISLNQPPPCLTGFLPASQWRAPADTSTAPLP
MMAR_0417|M.marinum_M IAQTVAAPFPNMAALDM-ALAINQPPPCLTGFIPAEQWRSFADTSLQPLP
MUL_1067|M.ulcerans_Agy99 IAQTVAAPFPNMAALDM-ALAINQPPPCLTGFIPAEQWRSFADTSLQPLP
MLBr_02594|M.leprae_Br4923 IAQTASATFPNMAALDL-ALSINQPPPCLTGFIPAAEWRSPADTSLQPLP
Mflv_0706|M.gilvum_PYR-GCK LLQMG-SIFQDGGLLHF-GLSINQPPPCMTGFLPASEWRSPADTSQAPLP
Mvan_0139|M.vanbaalenii_PYR-1 LLQMG-SIFEDGGLLHF-GLSINQPPPCMTGFLPASEWRSPADTSTAPLP
TH_2681|M.thermoresistible__bu IAQTTTAPFPGEALLHL-ALGINIPPPCLTGFLPPSQWRSPADTSPQPLP
MSMEG_0139|M.smegmatis_MC2_155 VAQTG-TIFAPEGLLHF-GLGINAPPPCLTGFLPASQWRSPADTRTEPLP
MAB_4148c|M.abscessus_ATCC_199 LTVAGGAPMDEGAKLDF-RLNLGDPPPCLTGFVPPPLMRTPADETLRELP
: : . * . : :. ****:***:*. *: ** **
Rv0594|M.tuberculosis_H37Rv KGTYCRIPMDA-SNVVRGARNNPCVDVPGKRAATPRECRSNEAYVPGGTN
Mb0610|M.bovis_AF2122/97 KGTYCRIPMDA-SNVVRGARNNPCVDVPGKRAATPRECRSNEAYVPGGTN
MAV_4546|M.avium_104 AGTYCKIPMDA-TNVVRGARNYPCVDVPGKRAATPRECRSTEPYVPQGTN
MMAR_0417|M.marinum_M KGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAATPRECRDPKPYVPAGTN
MUL_1067|M.ulcerans_Agy99 KGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAATPRECRDPKPYVPAGTN
MLBr_02594|M.leprae_Br4923 VGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSKPYVPLGTN
Mflv_0706|M.gilvum_PYR-GCK SGMYCKIPKDYQGNSVRGARNYPCPDVPGKRAASPKECRSDEPYVPLGTN
Mvan_0139|M.vanbaalenii_PYR-1 SGMYCKIPKDYQGNAVRGARNYPCVDVPGKRAASPKECRSDEPYVPLGTN
TH_2681|M.thermoresistible__bu EGTYCKIPKDTQGNVVRGGRNYPCVDVPGKRAATPRECRSDEPYVPLGTN
MSMEG_0139|M.smegmatis_MC2_155 SGLYCKIPKDAP-NAVRGARNYPCADVPGKRAATPRECRSDEPYQPLGTN
MAB_4148c|M.abscessus_ATCC_199 RDMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPIGSN
. **: . : . ***.** ** :.*****.: : **. . * * *:*
Rv0594|M.tuberculosis_H37Rv PWYGDPNQMLSCPAPAARCDQPVKPGQVIPAPSVNNGINPLPADQLP---
Mb0610|M.bovis_AF2122/97 PWYGDPNQMLSCPAPAARCDQPVKPGQVIPAPSVNNGINPLPADQLP---
MAV_4546|M.avium_104 PWYGDPDQILTCPAPGARCDQPVKPGLVIPAPSVDNGLNPLPADRLP---
MMAR_0417|M.marinum_M PWYGDPNQLLTCPAPGARCDQPVKPGLVAQAPSVNNGMNPAPADKLPPG-
MUL_1067|M.ulcerans_Agy99 PWYGDPNQLLTCPAPGARCDQSVKPGLVAQAPSVNNGMNPAPADKLPPG-
MLBr_02594|M.leprae_Br4923 PWFGDPNQLLTCPAPGARCDQPVKPGLVIPAPTVDNGLNPAPADRLP---
Mflv_0706|M.gilvum_PYR-GCK PWYGDPNQIVACPAPGARCDQRVAPGQVVPAPSINNGQNPLPADELPPPA
Mvan_0139|M.vanbaalenii_PYR-1 PWYGDPNQIVACPAPGARCDQRVAPGQVIPAPSVNNGQNPLPADQLPPPQ
TH_2681|M.thermoresistible__bu PWYGDPNQIRNCPAPGARCDQPVDPGKVIPAESVNNGMNPLPADRLPGP-
MSMEG_0139|M.smegmatis_MC2_155 PWYGDPDQIRNCPAPGARCDQPVDPGRVIPAPSINNGLNPLPASQLPPPE
MAB_4148c|M.abscessus_ATCC_199 PWRGPPAPYDTPVEDPRNILPPNKFPNIPPGAEPDPGTPTLPPPSPPAP-
** * * . : . : * . *. *
Rv0594|M.tuberculosis_H37Rv GTPPPVNDPLQRPG-SGTVQCNGQQPNPCVYTPSTFP---TTIYDVQSGK
Mb0610|M.bovis_AF2122/97 GTPPPVNDPLQRPG-SGTVQCNGQQPNPCVYTPSTFP---TTIYDVQSGK
MAV_4546|M.avium_104 GTPPPISDPLQRPG-SGTVVCNGQQPNPCTYTPS-------ALYDVRSGT
MMAR_0417|M.marinum_M GTPPPISDPLQRPG-SGTVQCNGQQPNPCVYTP-GPP---TAVYSPQSGE
MUL_1067|M.ulcerans_Agy99 GTPPPISDPLERPG-SGTVQCNGQQPNPCVYTP-GPP---TAVYSPQSGK
MLBr_02594|M.leprae_Br4923 GTPPPVSDPLSQPR-SGSVQCNGQQPNTCVYTPSGPP---SAVYSPQSGE
Mflv_0706|M.gilvum_PYR-GCK S-LAPVSDPVSPPG-SGTVRCSGQQPNPCTYTPAQGPPGTTAGYSPSSGE
Mvan_0139|M.vanbaalenii_PYR-1 S-LAPVSDPLSPPG-SGTVRCSGQQPNPCAYTPAQGPPGTTAGYSPSSGE
TH_2681|M.thermoresistible__bu --VPPVSDPLTPPGPSGMVECSGQQPNPCIYTPAPG----TAIYNPASGE
MSMEG_0139|M.smegmatis_MC2_155 VSSGPSSDPLTAPR-GGTVTCSGQQPNPCIYTPAAG---ATATYNPASGE
MAB_4148c|M.abscessus_ATCC_199 EVPPAGGDVMPVSAQSGPMAARAYDPKNGVFLDANNQ-------------
. .* : . .* : . . :*: :
Rv0594|M.tuberculosis_H37Rv VVAPDGVVYSVEASTHAGADGWKVMLAPTG--
Mb0610|M.bovis_AF2122/97 VVAPDGVVYSVEASTHAGADGWKVMLAPTG--
MAV_4546|M.avium_104 VVGPDGVVYSVANSATIGDEGWKTMLGQAR--
MMAR_0417|M.marinum_M LVGPDGVKYSVENSTKTGDDGWKEMLAPAG--
MUL_1067|M.ulcerans_Agy99 LVGPDGVKYSVENSTKTGDDGWKEMLAPAG--
MLBr_02594|M.leprae_Br4923 LVGPDGVAYAVENSTKTGDDGWKEMLAPAG--
Mflv_0706|M.gilvum_PYR-GCK VVGPDGVRYSVTNSTNPGDDGWKEMLAPAG--
Mvan_0139|M.vanbaalenii_PYR-1 VVGPDGVRYNVSNSNNPGDDGWKEMLAPAG--
TH_2681|M.thermoresistible__bu AVGPDGVKYSVSNSSNPGDDGWKEMLAPAG--
MSMEG_0139|M.smegmatis_MC2_155 VVGPGGVKYSVTNSNTPGDDGWKEMLAPAS--
MAB_4148c|M.abscessus_ATCC_199 -----PSVYAPALDRGTEAETWADLMLGPKPV
* . : * :: .