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VTTKLRRARSVLATALVLVAGVILAMRTADAAARTTVVAYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQP LRAKISFWFDRKYRVPADAAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRAQL QRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAISALGDHSKDIFSTVTNLSTLVTA LHDSADLLERLNHNLAAVTSLLADGPDKIGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVD SLDDIKQTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCGAIQAASRLGGEQAAKLCVQYLA PIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWLRPDYVAPVADTPPDPAAAVTVDPATGLRGMMMPPG GGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1969 | mce3D | - | 100% (423) | MCE-FAMILY PROTEIN MCE3D |
| M. tuberculosis H37Rv | Rv0172 | mce1D | 9e-81 | 39.38% (419) | MCE-family protein MCE1D |
| M. tuberculosis H37Rv | Rv0592 | mce2D | 3e-80 | 39.72% (428) | MCE-family protein MCE2D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0178 | mce1D | 8e-81 | 39.38% (419) | MCE-family protein MCE1D |
| M. gilvum PYR-GCK | Mflv_2104 | - | 1e-154 | 61.50% (439) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02592 | mce1D | 9e-80 | 37.30% (429) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 3e-60 | 32.90% (389) | MCE-family protein |
| M. marinum M | MMAR_2885 | mce3D | 0.0 | 82.67% (427) | MCE-family protein Mce3D |
| M. avium 104 | MAV_2535 | - | 1e-157 | 63.07% (436) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 1e-154 | 62.04% (432) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4580 | - | 1e-156 | 65.70% (414) | PUTATIVE putative transcriptional regulator, AraC family |
| M. ulcerans Agy99 | MUL_2867 | mce3D | 0.0 | 81.97% (427) | MCE-family protein Mce3D |
| M. vanbaalenii PYR-1 | Mvan_3979 | - | 1e-171 | 70.05% (424) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0178|M.bovis_AF2122/97 MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLTNNTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MMAR_2885|M.marinum_M ----------MTTRLRRTRSVLATTLILVLVAGVIAAMRTAGDATRTLVV
MUL_2867|M.ulcerans_Agy99 ----------MTTRLRRTRSVLATTLILVLVAGVIAAMRTAGDATRTLVV
Rv1969|M.tuberculosis_H37Rv ----------MTTKLRRARSVLAT--ALVLVAGVILAMRTADAAARTTVV
Mvan_3979|M.vanbaalenii_PYR-1 ----------MSARLRRARGGLAAVLVLTLAAGFLVAARAADHVERIWVT
MSMEG_0349|M.smegmatis_MC2_155 ------------MRISKKQLTLAAGLVVVMVAGVLVGFRMTGPAARTTIT
TH_4580|M.thermoresistible__bu ---------------------VAVALIVVLFAGIVGTVRLAQQGSRMTVV
Mflv_2104|M.gilvum_PYR-GCK --------------MKNLRLWVGLVLVALLVVGVALLVRTTDKVNRVNVV
MAV_2535|M.avium_104 ---------------------MAIALTAVLLGGIVTVVRSAAGVGRTTVV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
. :.
Mb0178|M.bovis_AF2122/97 AYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPAN
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MMAR_2885|M.marinum_M AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRSKISFWFDRKYKVPAD
MUL_2867|M.ulcerans_Agy99 AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRSKISFWFDRKYKVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
Mvan_3979|M.vanbaalenii_PYR-1 AYFENSNGLFAGDDVRILGVPVGRVDSIRPEPTRARITFWVDRRYPVPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
TH_4580|M.thermoresistible__bu AYFENTTGVFPGDDVRILGVRVGQISAIEPQPDRVKVTFWVDERYPVPAE
Mflv_2104|M.gilvum_PYR-GCK AYFENSNGIYEGDDVRILGVPVGRITSIEPEPERVKISFWYDDRYDVPAD
MAV_2535|M.avium_104 GYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWLNDKYKVPAD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* : .:: **.* * *: .* : : * :::: .: **
Mb0178|M.bovis_AF2122/97 ASAVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MMAR_2885|M.marinum_M AKAAILSPQLVTGRAIQLTPPYSGGPTMASGAIISQQRTAVPVEWDDLRN
MUL_2867|M.ulcerans_Agy99 AKAAILSPQLVTGRAIQLTPPYSGGPTTASGAIISQQRTAVPVEWDDLRN
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
Mvan_3979|M.vanbaalenii_PYR-1 AKAVILSPQLVTGRAIQLTPAYTGGPVMPTGTVVGQERTAVPVEWDDVRV
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
TH_4580|M.thermoresistible__bu VNAVILSPQLVTGRAIQLTPAYTSGPMLADGAEIPLARTAVPVEWDDVRE
Mflv_2104|M.gilvum_PYR-GCK AAAAILSPALVTARAIQLTPVYTGGPVLGDNAVIPLQRTVVPVEWDQVRA
MAV_2535|M.avium_104 VKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQ
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: * **: * :** * * .* : : :* ** .:*:.:
Mb0178|M.bovis_AF2122/97 SVSHIIDELGPTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALN
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MMAR_2885|M.marinum_M QLQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVS
MUL_2867|M.ulcerans_Agy99 QLQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
Mvan_3979|M.vanbaalenii_PYR-1 QLQRLTKLLRPTEPGGVSTLGAFINTTADNLRGQGANIRQTVVKLSQALA
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
TH_4580|M.thermoresistible__bu QLARVTQLLQPTAPGEPSTLGRAIDTAADNLRGQGPTIRDTIVRLSRAMS
Mflv_2104|M.gilvum_PYR-GCK QLERLSETLQPTEPGGVSPLGSVINTTAENLRGQGADIRETVIKLSQAFS
MAV_2535|M.avium_104 QLEKLTQVLQPTAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAIS
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQG-QSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: :: * * .... *: * : *:* :. :: **::
Mb0178|M.bovis_AF2122/97 ALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNKNLAEFTDRLTHSDAD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MMAR_2885|M.marinum_M TLSDHRNDIFSTVRNLSTLVSALHDSADLLEQLNHNLAAVSSLLATDPNK
MUL_2867|M.ulcerans_Agy99 TLSDHRNDIFSTVRNLSTLVSALHDSADLLEQLNHNLAAVSSLLATDPNK
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
Mvan_3979|M.vanbaalenii_PYR-1 ILGDHSDDIFTTFTNLSTLVSALHDSADLLEQLNQNMAAVTSLIADDPQK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
TH_4580|M.thermoresistible__bu ALGDHSQDVFGSLRNLSTLVSALHDSTGLLEQLNHNMAAVSALLAEDPDK
Mflv_2104|M.gilvum_PYR-GCK ALGDRSTDIFSTIKNLAILVSALQDSTDLMRQLNQNLASVSGLLTDGPDE
MAV_2535|M.avium_104 ALGDHSNDLFSTVKNLSILVSALHDSSDLLQQLNQNLAEVTGLLANDPNE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
:.: *.* . .* :* ** . : :. ::* .: :: . .
Mb0178|M.bovis_AF2122/97 LSNAIQQFDSLLAVARPFFAKNREVLTHDVNNLATVTTTLLQPDPLDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MMAR_2885|M.marinum_M VGQAVEDINAVVADVQSFAAENREAVGTASDKLASISNALVAS--LDDIK
MUL_2867|M.ulcerans_Agy99 VGQAVKDINAVVADVQSFAAEYREAVGTASDKLASISNALVAS--LDDIK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVDS--LDDIK
Mvan_3979|M.vanbaalenii_PYR-1 VARTVQDLGGVIGDVKEFADDNREAIGTATDTLASVSTALVDS--LDDLK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALVQS--LDDIK
TH_4580|M.thermoresistible__bu VGRVVADLHALVGDLQQFVADNREPLEIASTRLDSVGTALVDS--IDDIK
Mflv_2104|M.gilvum_PYR-GCK VANAIRDLNAAVGDVQSFVAENRESLGTTSDKLAGVTTALTES--LEDIK
MAV_2535|M.avium_104 VANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVTDS--LGDVK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQ--SDDLE
:. . : * . .. : . . .::
Mb0178|M.bovis_AF2122/97 TVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFANPMEFICS-SIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
MMAR_2885|M.marinum_M QTLHIGPTVLQNFNNIFEPANGALTGALAANDFANPISFLCG-AIQSASR
MUL_2867|M.ulcerans_Agy99 QTLHIGPTVLQNLNNIFEPANGALTGALAANDFANPISFLCG-AIQSASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
Mvan_3979|M.vanbaalenii_PYR-1 QTLHIAPGTVANFHNIFEPANGSLTGALAVNNFANPISFICG-AIQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
TH_4580|M.thermoresistible__bu QALHVAPTVLQNFSNIYEAANGSFTGALAANNFANPIQFLCG-AVQAASR
Mflv_2104|M.gilvum_PYR-GCK QFLHVAPSTFQNYINIWQPAQGAVSSVPQINNFANPIQFLCG-AVQAASR
MAV_2535|M.avium_104 QLLHTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCG-AVEAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
** * * :::..: * . . ::::.: *:*. .::.::
Mb0178|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSEPRL
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSEARL
MMAR_2885|M.marinum_M LGGEQAAKLCVQYLAPILKNRQYNFPPLGENLFVGAQARPNEVTYSEDWM
MUL_2867|M.ulcerans_Agy99 LGGEQAAKLCVQYLAPILKNRQYNFPPLGENLFVGAQARPNEVTYGEDWM
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWL
Mvan_3979|M.vanbaalenii_PYR-1 HGAEQSAKLCAQYLAPIVKNRQYNFPPIGENLLVGTQARPNEVTYSEDWL
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWL
TH_4580|M.thermoresistible__bu LGAEQAAKLCVQYLAPIVKNRQYNFPPLGLNLFVGAQARPNEVTYSEPWM
Mflv_2104|M.gilvum_PYR-GCK LGAEESAKLCVQYLAPIIKNRQYNFPPLGLNQLVGATTRPNELTYSEDWL
MAV_2535|M.avium_104 LGAKESAKLCVQYLAPIIKNRQVNFPPLGENLFVGAAARPNELTYSEDWL
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. *::* : :.*:: *: *: : . :: :.
Mb0178|M.bovis_AF2122/97 QPPNGYKDTTVPGIWVPDTPLSHRNTQPG-WVVAPGMQGVQVGPITQGLL
MLBr_02592|M.leprae_Br4923 QPPSGYKDTTVPGIWVPDTPLSHRNTQPG-WIVAPGMQGQQVGPITAALM
MMAR_2885|M.marinum_M RPD-----------YVPPQP---------------------------DMP
MUL_2867|M.ulcerans_Agy99 RPD-----------YVPPQP---------------------------DMP
Rv1969|M.tuberculosis_H37Rv RPD-----------YVAPVA---------------------------DTP
Mvan_3979|M.vanbaalenii_PYR-1 RPD-----------FVPP-----------------------------AAP
MSMEG_0349|M.smegmatis_MC2_155 RPD-----------YIPPAQPVTQ------------------DLDPEVLP
TH_4580|M.thermoresistible__bu RPD-----------YVPPLP--------------------------AEAA
Mflv_2104|M.gilvum_PYR-GCK RPD-----------YIPPGGPAPAPAAGVPTGDPAGLPPGQGP-LLLDAP
MAV_2535|M.avium_104 RPD-----------YVPP-HPDSPPTGDAPAPPAAGATPAEAPPPAADAP
MAB_4150c|M.abscessus_ATCC_199 EAKSQAPRED--LVWVRPNGAPPPPKPSP-----QDLSALMLGPDEVNAP
.. ::
Mb0178|M.bovis_AF2122/97 TPESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIP
MLBr_02592|M.leprae_Br4923 TPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQAS-VPIP
MMAR_2885|M.marinum_M PAERPADVTVEPDPAAGLRGMMVPPGGG----------------------
MUL_2867|M.ulcerans_Agy99 PAEPPADVTVEPDPAAGLRGMMVPPGGG----------------------
Rv1969|M.tuberculosis_H37Rv P-DPAAAVTVDP--ATGLRGMMMPPGGGS---------------------
Mvan_3979|M.vanbaalenii_PYR-1 PADQPQAVAVDP--DAGLQGMMVPAGGGVS--------------------
MSMEG_0349|M.smegmatis_MC2_155 AEAAPTDGSADP--SAGLPGLMIPTEAGS---------------------
TH_4580|M.thermoresistible__bu PAASPHGTTVAADPAAGLPGLLLPHGGDR---------------------
Mflv_2104|M.gilvum_PYR-GCK PGAAEMPVPTNP--TDGLHGMMVPPGGGS---------------------
MAV_2535|M.avium_104 P--PAQAAPTNP--AEGLRGMMMPPGGGQ---------------------
MAB_4150c|M.abscessus_ATCC_199 PPPGTEVRPAEPGPVPPGFPVTADDAPPPAIPGAPR--------------
. . :
Mb0178|M.bovis_AF2122/97 PPPPGPDVIPGPVPPTPAPVG----APLPAEAGGGQ
MLBr_02592|M.leprae_Br4923 SP--RPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
MMAR_2885|M.marinum_M ------------------------------------
MUL_2867|M.ulcerans_Agy99 ------------------------------------
Rv1969|M.tuberculosis_H37Rv ------------------------------------
Mvan_3979|M.vanbaalenii_PYR-1 ------------------------------------
MSMEG_0349|M.smegmatis_MC2_155 ------------------------------------
TH_4580|M.thermoresistible__bu ------------------------------------
Mflv_2104|M.gilvum_PYR-GCK ------------------------------------
MAV_2535|M.avium_104 ------------------------------------
MAB_4150c|M.abscessus_ATCC_199 ------------------------------------