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MKNLRLWVGLVLVALLVVGVALLVRTTDKVNRVNVVAYFENSNGIYEGDDVRILGVPVGRITSIEPEPER VKISFWYDDRYDVPADAAAAILSPALVTARAIQLTPVYTGGPVLGDNAVIPLQRTVVPVEWDQVRAQLER LSETLQPTEPGGVSPLGSVINTTAENLRGQGADIRETVIKLSQAFSALGDRSTDIFSTIKNLAILVSALQ DSTDLMRQLNQNLASVSGLLTDGPDEVANAIRDLNAAVGDVQSFVAENRESLGTTSDKLAGVTTALTESL EDIKQFLHVAPSTFQNYINIWQPAQGAVSSVPQINNFANPIQFLCGAVQAASRLGAEESAKLCVQYLAPI IKNRQYNFPPLGLNQLVGATTRPNELTYSEDWLRPDYIPPGGPAPAPAAGVPTGDPAGLPPGQGPLLLDA PPGAAEMPVPTNPTDGLHGMMVPPGGGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2104 | - | - | 100% (448) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_0649 | - | e-152 | 59.56% (450) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_0708 | - | 1e-86 | 43.56% (388) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0178 | mce1D | 2e-84 | 38.85% (453) | MCE-family protein MCE1D |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-154 | 61.50% (439) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 4e-87 | 43.37% (392) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 3e-71 | 34.14% (454) | MCE-family protein |
| M. marinum M | MMAR_4054 | mce3D_1 | 0.0 | 71.65% (448) | MCE-family protein Mce3D_1 |
| M. avium 104 | MAV_2535 | - | 1e-167 | 65.84% (445) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 1e-141 | 56.15% (447) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3797 | - | 1e-154 | 61.56% (437) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3921 | mce3D_1 | 0.0 | 71.43% (448) | MCE-family protein Mce3D_1 |
| M. vanbaalenii PYR-1 | Mvan_4601 | - | 0.0 | 72.65% (457) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0178|M.bovis_AF2122/97 MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLTNNTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MMAR_4054|M.marinum_M -------------MIRRTKTWLAVLLVGLLAAGVVVLLRTTEVVNRTNVV
MUL_3921|M.ulcerans_Agy99 -------------MIRRTKTWLAVLLVGLLAAGVVVLLRTTEVVNRTNVV
Mvan_4601|M.vanbaalenii_PYR-1 -------------MTRTLRILLIASLSVILVGGVVVLLRTTEAINRTHAV
Mflv_2104|M.gilvum_PYR-GCK --------------MKNLRLWVGLVLVALLVVGVALLVRTTDKVNRVNVV
MAV_2535|M.avium_104 ---------------------MAIALTAVLLGGIVTVVRSAAGVGRTTVV
Rv1969|M.tuberculosis_H37Rv ------------MTTKLRRARSVLATALVLVAGVILAMRTADAAARTTVV
MSMEG_0349|M.smegmatis_MC2_155 ------------MRISKKQLTLAAGLVVVMVAGVLVGFRMTGPAARTTIT
TH_3797|M.thermoresistible__bu ----------VTQLNRHRNIALAAVLVLTLVAGMIILVRMYAASDRVQYT
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
.
Mb0178|M.bovis_AF2122/97 AYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPAN
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MMAR_4054|M.marinum_M AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVKVSFWYDSKYKVPAD
MUL_3921|M.ulcerans_Agy99 AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVRVSFWYDSKYIVPAD
Mvan_4601|M.vanbaalenii_PYR-1 AYFENSNGIYAGDAVSIVGVPVGKIESIEPQPESVKVSFWYDSKYKVPAD
Mflv_2104|M.gilvum_PYR-GCK AYFENSNGIYEGDDVRILGVPVGRITSIEPEPERVKISFWYDDRYDVPAD
MAV_2535|M.avium_104 GYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWLNDKYKVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
TH_3797|M.thermoresistible__bu AYFENSNGVYPGDEVRILGVPVGQIDTVEPEPDRAKITFWVSEKYRVPAD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* : .:: ** * * *: .* : : * :::: .: ** .
Mb0178|M.bovis_AF2122/97 ASAVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MMAR_4054|M.marinum_M AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
MUL_3921|M.ulcerans_Agy99 AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
Mvan_4601|M.vanbaalenii_PYR-1 AKAVILSPTLVTARTIQLTPAYTGGPVMENDAVIPRERTAVPVEWDEVRQ
Mflv_2104|M.gilvum_PYR-GCK AAAAILSPALVTARAIQLTPVYTGGPVLGDNAVIPLQRTVVPVEWDQVRA
MAV_2535|M.avium_104 VKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQ
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
TH_3797|M.thermoresistible__bu VRAVILSPQLVTARSIELTPAYTGGPTLQPGEVIPEDRTAVPVEWDDLRE
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: * **: * ::* * * .* : : ::* ** .:*:.:
Mb0178|M.bovis_AF2122/97 SVSHIIDELGPTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALN
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MMAR_4054|M.marinum_M QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
MUL_3921|M.ulcerans_Agy99 QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
Mvan_4601|M.vanbaalenii_PYR-1 QLAKLADTLQPTEPGGVSPLGSVINTTADNLRGEGANIRDTVIKLSQAIS
Mflv_2104|M.gilvum_PYR-GCK QLERLSETLQPTEPGGVSPLGSVINTTAENLRGQGADIRETVIKLSQAFS
MAV_2535|M.avium_104 QLEKLTQVLQPTAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAIS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
TH_3797|M.thermoresistible__bu QLEKLTDALQPTEPGGVSTLGEFINTSAENLRGQGTDIRETVIKLSQAIS
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQG-QSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: :: * * .... .*: * : *:* :. :: .**::
Mb0178|M.bovis_AF2122/97 ALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNKNLAEFTDRLTHSDAD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MMAR_4054|M.marinum_M ALGDHSTDIFSTVKNLAILVSALQDSTNFMRQLNQNLATVTGLLANDPNE
MUL_3921|M.ulcerans_Agy99 ALGDHSTDIFSTVKNLAILVSALQDSTNLMRQLNQNLATVTGLLANDPNE
Mvan_4601|M.vanbaalenii_PYR-1 ALGDNSTNIFSTVKNLATLVSALQDSTNLMRQLNQNLASVTGLLANDPDE
Mflv_2104|M.gilvum_PYR-GCK ALGDRSTDIFSTIKNLAILVSALQDSTDLMRQLNQNLASVSGLLTDGPDE
MAV_2535|M.avium_104 ALGDHSNDLFSTVKNLSILVSALHDSSDLLQQLNQNLAEVTGLLANDPNE
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
TH_3797|M.thermoresistible__bu ILGDHSDDLFTSIKNVSLLVSALHDSTDLLRQLNANLAQATGLLTNGPNE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
:.: :.* : .: :* ** . : : :. ::* : *: . .
Mb0178|M.bovis_AF2122/97 LSNAIQQFDSLLAVARPFFAKNREVLTHDVNNLATVTTTLLQPDPLDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MMAR_4054|M.marinum_M VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALNDS--LDDVK
MUL_3921|M.ulcerans_Agy99 VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALNDS--LDDVK
Mvan_4601|M.vanbaalenii_PYR-1 VANAVRDLDKAVGEVQTFVADNRESLGTTSDKLAGVTQALTDS--LADVK
Mflv_2104|M.gilvum_PYR-GCK VANAIRDLNAAVGDVQSFVAENRESLGTTSDKLAGVTTALTES--LEDIK
MAV_2535|M.avium_104 VANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVTDS--LGDVK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVDS--LDDIK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALVQS--LDDIK
TH_3797|M.thermoresistible__bu VGQALADLDAAVRDVTDFVADNREAVGTTTNRLASITSALDES--VEEVK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQ--SDDLE
:. : :. . * . .. : : : . . : ::
Mb0178|M.bovis_AF2122/97 TVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFANPMEFICS-SIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
MMAR_4054|M.marinum_M QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
MUL_3921|M.ulcerans_Agy99 QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
Mvan_4601|M.vanbaalenii_PYR-1 QFLHVAPNTLQNYVNIWQPAQGAVSSVPMINNFADPVSFLCG-AVQAASR
Mflv_2104|M.gilvum_PYR-GCK QFLHVAPSTFQNYINIWQPAQGAVSSVPQINNFANPIQFLCG-AVQAASR
MAV_2535|M.avium_104 QLLHTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCG-AVEAASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
TH_3797|M.thermoresistible__bu QALHIAPNTLANFYNIYQPAQAALTGALAVNNFADPVSFLCG-AIQAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
** *. * :::.*: . : . *:::.: *:*. .::.::
Mb0178|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSEPRL
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSEARL
MMAR_4054|M.marinum_M LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSEDWL
MUL_3921|M.ulcerans_Agy99 LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSEDWL
Mvan_4601|M.vanbaalenii_PYR-1 LGAEESAKLCVQYMAPIIKNRQYNFLPLAQNVFVGATTRPNELTYSEDWL
Mflv_2104|M.gilvum_PYR-GCK LGAEESAKLCVQYLAPIIKNRQYNFPPLGLNQLVGATTRPNELTYSEDWL
MAV_2535|M.avium_104 LGAKESAKLCVQYLAPIIKNRQVNFPPLGENLFVGAAARPNELTYSEDWL
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWL
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWL
TH_3797|M.thermoresistible__bu LGAEESSKLCVQYLAPIVKNRQYNFLPFGLNPFVGAAARPNEITYSEDWM
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. :::* : :.*:: *: *: : . :: :.
Mb0178|M.bovis_AF2122/97 QPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLT
MLBr_02592|M.leprae_Br4923 QPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAALMT
MMAR_4054|M.marinum_M R-------------------------------------------------
MUL_3921|M.ulcerans_Agy99 R-------------------------------------------------
Mvan_4601|M.vanbaalenii_PYR-1 R-------------------------------------------------
Mflv_2104|M.gilvum_PYR-GCK R-------------------------------------------------
MAV_2535|M.avium_104 R-------------------------------------------------
Rv1969|M.tuberculosis_H37Rv R-------------------------------------------------
MSMEG_0349|M.smegmatis_MC2_155 R-------------------------------------------------
TH_3797|M.thermoresistible__bu R-------------------------------------------------
MAB_4150c|M.abscessus_ATCC_199 EAKSQAP-------------------------------------------
.
Mb0178|M.bovis_AF2122/97 PESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYP-VLPPIGLQAPQVPIP
MLBr_02592|M.leprae_Br4923 PDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHP-VPPPIGLQAS-VPIP
MMAR_4054|M.marinum_M PDYIPPQ----AIPPQAIPPQQAPPAAAPPAQAP--PPAVGPPLPAEA-P
MUL_3921|M.ulcerans_Agy99 PDYIPPQ----AIP-----PQQAPPAAAPPAQAP--PPAVGLPLPAEA-P
Mvan_4601|M.vanbaalenii_PYR-1 PDYIPPQPGSAAPPPPAGAPQPAAGAPQPPAGAPL-PPALGPLLPAEAVP
Mflv_2104|M.gilvum_PYR-GCK PDYIPPG---GPAPAPAAGVPTGDPAGLPPGQGP---LLLDAPPGAAEMP
MAV_2535|M.avium_104 PDYVPPH----PDSPPTGDAPAPPAAGATPAEAP--PPAADAPPPAQA--
Rv1969|M.tuberculosis_H37Rv PDYVAPV------------------ADTPPD------PAAAVTVD-----
MSMEG_0349|M.smegmatis_MC2_155 PDYIPPA------------------QPVTQDLDPEVLPAEAAPTDGS---
TH_3797|M.thermoresistible__bu PDYRPMS------------------LPAPADQS---LPAEEPVVPAVR--
MAB_4150c|M.abscessus_ATCC_199 REDLVWVRPNGAPPPPKPSPQDLSALMLGPDEVNAPPPPGTEVRPAEPGP
:
Mb0178|M.bovis_AF2122/97 PPPPGPDVIPGPVPPTPAPVG----APLPAEAGGGQ
MLBr_02592|M.leprae_Br4923 SP--RPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
MMAR_4054|M.marinum_M ATPDPAAGLRGIMVPQ----------------GVGS
MUL_3921|M.ulcerans_Agy99 ATPDPAAGLRGIMVPQ----------------GVGS
Mvan_4601|M.vanbaalenii_PYR-1 TAPNPADGLQGLMVPA----------------GAGS
Mflv_2104|M.gilvum_PYR-GCK VPTNPTDGLHGMMVPP----------------GGGS
MAV_2535|M.avium_104 APTNPAEGLRGMMMPP----------------GGGQ
Rv1969|M.tuberculosis_H37Rv ----PATGLRGMMMPP----------------GGGS
MSMEG_0349|M.smegmatis_MC2_155 --ADPSAGLPGLMIPT----------------EAGS
TH_3797|M.thermoresistible__bu -AADPSQGLPGLMIPH----------------GGGR
MAB_4150c|M.abscessus_ATCC_199 VPPGFPVTADDAPPPAIP--------------GAPR
. . *