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MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVVAYFSEALALYPGDKVQIMGV RVGSIDKIEPAGDKMRVTLHYSNKYQVPATATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQ VPVEWDQLRDSINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALTALNEGRGDFV AITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHDLADTVERIDDVLGTVRKFVSDNRSVLAADV NNLADATTTLVQPEPRDGLETALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLICSAIQAGSRL GYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSEERLRPPPGYKDTTVPGIFSRDTPF SHGNHEPGWVVAPGMQGMQVQPFTANMLTPESLAELLGGPDIAPPPPGTNLPGPPNAYDESNPLPPPWYP QPASLPAAGATGQPGPGQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0592 | mce2D | - | 100% (508) | MCE-FAMILY PROTEIN MCE2D |
| M. tuberculosis H37Rv | Rv0172 | mce1D | 0.0 | 68.16% (512) | MCE-family protein MCE1D |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 3e-80 | 39.72% (428) | MCE-family protein MCE3D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0607 | mce2Da | 0.0 | 99.15% (471) | hypothetical protein Mb0607 |
| M. gilvum PYR-GCK | Mflv_0708 | - | 0.0 | 66.67% (513) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02592 | mce1D | 0.0 | 66.34% (508) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 1e-66 | 33.26% (457) | MCE-family protein |
| M. marinum M | MMAR_0415 | mce1D | 0.0 | 65.42% (509) | MCE-family protein Mce1D |
| M. avium 104 | MAV_4548 | - | 0.0 | 80.31% (508) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0137 | - | 0.0 | 66.09% (516) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3020 | - | 1e-176 | 66.82% (440) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1065 | mce1D | 0.0 | 65.03% (509) | MCE-family protein Mce1D |
| M. vanbaalenii PYR-1 | Mvan_0137 | - | 0.0 | 68.74% (515) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0592|M.tuberculosis_H37Rv MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVV
Mb0607|M.bovis_AF2122/97 MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVV
MAV_4548|M.avium_104 MSTIFDIRNLRLPKVSARVLVIAALAAVFVFIAAVAGVQLYRKLTTTTVV
Mflv_0708|M.gilvum_PYR-GCK MSTIFNVRNMKGPGLSRG-LIIGAVVLVLVVVGAFLGMKLYKQMTTKTVV
Mvan_0137|M.vanbaalenii_PYR-1 MSTVFNVRNLKSPGASRATLIIGVIVVVLAVVGAVLGWNLYKQMTTKTVV
MSMEG_0137|M.smegmatis_MC2_155 MSTIFNIRNIQLPRLSRAAVIIGALVVAAALVAGYFGMNAYRKLTNTTVT
TH_3020|M.thermoresistible__bu MSTIFNVRNLRLPRLSRTAVILGALVVALALVAAVVGYQLYKRITTNTAV
MMAR_0415|M.marinum_M MSTIFDIRNIRLPKVSRATVIIGSLVLVLGLVAAFVGLKLYQKLTNNTVV
MUL_1065|M.ulcerans_Agy99 MSTIFDIRNIRLPEVSRATVIIGSLVLVLGLVAAFVGLKLYQKLTNNTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
* : . .. : . : . . .
Rv0592|M.tuberculosis_H37Rv AYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPAT
Mb0607|M.bovis_AF2122/97 AYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPAT
MAV_4548|M.avium_104 AYFSETLALYPGDRVQIMGVRVGSIDKIEPAGDKMRVTLHYNNKYRVPAN
Mflv_0708|M.gilvum_PYR-GCK AYFTQTLAIYPGDKVQIMGVQVGAIDKIEPAGDKMKVTFHYEDKYRVPEN
Mvan_0137|M.vanbaalenii_PYR-1 AYFTQTLAIYPGDKVQIMGVQVGSIDKIEPAGDKMKVTFHYAGKYKVPQD
MSMEG_0137|M.smegmatis_MC2_155 AYFPEVLALYPGDKVLIMGVRVGSIDSIETAGDKMKVVFHFNNKYKVPEN
TH_3020|M.thermoresistible__bu AYFEQTLALYPGDKVQIMGVHVGNIDTIEPAGDKMKVTFHYDSKYKLPSD
MMAR_0415|M.marinum_M AYFPSANALYPGDKVQIMGLQVGKIDNIEPAGDKMKVTFHYQNKYKVPAN
MUL_1065|M.ulcerans_Agy99 AYFPSANALYPGDKVQIMGLQVGKIDNIEPAGDKMKVTFHYQNKYKVPAN
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* . .:*.** * *:*::.* *. : . ..::*.:. .*:::*
Rv0592|M.tuberculosis_H37Rv ATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRD
Mb0607|M.bovis_AF2122/97 ATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRD
MAV_4548|M.avium_104 ATASILNPSLVASRTIQLSPPYTGGPVLRDGAVIPIERTRVPVEWDQLRD
Mflv_0708|M.gilvum_PYR-GCK ATASILNPSLVASRTIQLSPAYTGGNTLPDNAVLDIDRTQVPVEYDDLRD
Mvan_0137|M.vanbaalenii_PYR-1 ATASILNPSLVASRTIQLSPPYTGGPVLADGAVLDVDRTQVPVEYDDVRD
MSMEG_0137|M.smegmatis_MC2_155 ATASILNPSLVASRVIQLSPPYTGGPTLRDGAVLDVDRTQVPIEYDEVRN
TH_3020|M.thermoresistible__bu VSASILNPSLVASRSIQLSPPYTGGDTFPDGGVIPIERTQVPVEWDELRN
MMAR_0415|M.marinum_M ASAVILNPTLVASRTIQLEPPYKGGPVLADNAVIPLERTQVPVEWDELRN
MUL_1065|M.ulcerans_Agy99 ASAVILNPTLVASRTIQLEPPYKGGPVLADNAVIPLERTQVPVEWDELRN
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: *.**::* :** *.*..* .: *.. : :::* **:*:*:::
Rv0592|M.tuberculosis_H37Rv SINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALT
Mb0607|M.bovis_AF2122/97 SINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALT
MAV_4548|M.avium_104 SINAILRQLGPTPQQPAGPFGDIIESAADNLSGKGKQVNETLNSLSQALT
Mflv_0708|M.gilvum_PYR-GCK SISRLLTDLGPTPEQPKGPFGDIIESAADGFAGKGKQLNSTLNNLSEALF
Mvan_0137|M.vanbaalenii_PYR-1 SISRLLTDLGPTPEQPKGPFGDIIESAADGFAGKGEQLNKTLNNLSEALF
MSMEG_0137|M.smegmatis_MC2_155 QVTRLLADLGPTPEQPKGPFGDIIESFADGFAGKGEQLNRTLRGLSDALT
TH_3020|M.thermoresistible__bu SIDRILTDLGPTDEQPMGPFGDVVDSFADGLAGKGQQINQTLTSLSEALT
MMAR_0415|M.marinum_M SITNIIDKLGPTKDQPTGPFGEVLESFANGLEGKGKQINTTLDSLSRALT
MUL_1065|M.ulcerans_Agy99 SITNIIDKLGPTKDQPTGPFGEVLESFANGLEGKGKQINTTLDSLSRALI
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQ-GQSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: : .*** *. **..:.::. * : *:* ... :: ** *
Rv0592|M.tuberculosis_H37Rv ALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHD
Mb0607|M.bovis_AF2122/97 ALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHD
MAV_4548|M.avium_104 ALNEGRGDFVAITKSLARFVTALYQHKQQFVALNNNLAQFTDWFTQSDHQ
Mflv_0708|M.gilvum_PYR-GCK ALNEGRGDFFSVVKSLATFVNALHQSDQQFVALNNDLAQFTNAFTDSDRE
Mvan_0137|M.vanbaalenii_PYR-1 ALNEGRGDFFSVVKSLALFVNALHQSDQQFVALNNNLAQFTNAFTDTDRE
MSMEG_0137|M.smegmatis_MC2_155 ALNEGRGDFFAVVKSLALFVNALHRSDQQFVALNNDLAQFTNSFTNTDQE
TH_3020|M.thermoresistible__bu ALNEGRGDFFGVVKSLALFVNALHRSDQQFVALNRDLAQFTTSFANTDQE
MMAR_0415|M.marinum_M ALNEGRGDFFAVVRSLALFVNALHQDDKQFVALNQNLADVTGRLVGYDRD
MUL_1065|M.ulcerans_Agy99 ALNEGRGDFFAVVRSLALFVNALHQDDKQFVALNQNLADVTGRLVGYDRD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
*.:.* *:.. :.* :* ** .:*:* :. .**..: :. :
Rv0592|M.tuberculosis_H37Rv LADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLE
Mb0607|M.bovis_AF2122/97 LADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLE
MAV_4548|M.avium_104 VSDTIAHLDQVLDAARKFVNDNGSALTHDVGNLADVTTTILQPEPRDGLE
Mflv_0708|M.gilvum_PYR-GCK VANALQDLDELLTTTRGFIDENGEVLAHDVQNLAEVTNAILQPEPLDGLE
Mvan_0137|M.vanbaalenii_PYR-1 VADALRDLNELLTTTRNFVDENGEVLAHDVQNLADVTNAILQPEPRDGLE
MSMEG_0137|M.smegmatis_MC2_155 LANALQDLNRVLKTTREFLDRNGGVLTHDIDNLEQVTTAILQPEPRDGLE
TH_3020|M.thermoresistible__bu LANAVRDLDELLTTTRQFLDENAEVLTYDINNLAEVTNAILQPEPLDGLE
MMAR_0415|M.marinum_M LSNALQQFDSLLSTVRPFLDKNREVLTYDVNNLAEATNTLLQPDPLNGLE
MUL_1065|M.ulcerans_Agy99 LSNALQQFDSLLSTVRPFLDKNREVLTYDVNNLAEATNTLLQPDPLNGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFS--DQSDDLE
:. :: :: * .: *: . .* :: :* . . : :.:*
Rv0592|M.tuberculosis_H37Rv TALHVLPTYASNFNNLYYPLHSSLVGQFVFP---NFANPIQLICS-AIQA
Mb0607|M.bovis_AF2122/97 TALHVLPTYASNFNNLYYPLHSSLVGQFVFP---NFANPIQLICS-AIQA
MAV_4548|M.avium_104 TALHVLPTFAGNFNNLYQPAHSSLVGLFVFP---NFANPIHFLCS-AIQA
Mflv_0708|M.gilvum_PYR-GCK TALHAYPNVAANLMNISSPNAGGIVTMPVIS---NFANPMQFLCS-AIQA
Mvan_0137|M.vanbaalenii_PYR-1 TALHAYPNVAANLMNISSPNAGGIVTMPVIS---NFANPMQFLCS-AIQA
MSMEG_0137|M.smegmatis_MC2_155 TGLHAYPNLAANVLNINSPNQGGIIGLPVLPGVTNFSNPLQFVCS-SIQA
TH_3020|M.thermoresistible__bu TALHVFPTMGANIMNISSPNSGGIVSLPVVT---NFANPLQFICS-AIQA
MMAR_0415|M.marinum_M TALHVLPTAASNVNQIYHPAHGSVVAVPEIT---SFANPMQFVCS-SIQA
MUL_1065|M.ulcerans_Agy99 TALHVLPTAASNVNHIYHPAHGSVVAVPEIT---SFANPMQFVCS-SIQA
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTIT---NFANPMQFICS-AIQA
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIP---NLANPVQFICGGVFET
**. *. .*. :: * . : .. .::**::::*. :::
Rv0592|M.tuberculosis_H37Rv GSRLGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSE
Mb0607|M.bovis_AF2122/97 GSRLGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSE
MAV_4548|M.avium_104 GSRLGYQDSAELCAQYLAPVLDAIKFNYPPAGLNPFNSAATLPKEVAYSE
Mflv_0708|M.gilvum_PYR-GCK GSRLGYQESAELCAQYLGPILDAIKFNYLPFGANQLQTAMTLPKQISYSE
Mvan_0137|M.vanbaalenii_PYR-1 GSRLGYQESAELCAQYLGPILDAIKFNYLPFGANQLQTAMTLPKQIAYSE
MSMEG_0137|M.smegmatis_MC2_155 GSRLGYQESAELCAQYLAPIMDAIKFNYLPFGMNLASTAMTLPKQIAYSE
TH_3020|M.thermoresistible__bu GSRLGYQESAELCAEYLAPILDAIKFNFPPFGFNQITTASVLPKQVAYSE
MMAR_0415|M.marinum_M GSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNAFNTAEVLPKQVAYSE
MUL_1065|M.ulcerans_Agy99 GSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNAFNTAEVLPKQVAYSE
MLBr_02592|M.leprae_Br4923 GSRLGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSE
MAB_4150c|M.abscessus_ATCC_199 GTKTEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDT
*:: * . **:* : :.*:: .**: * : . :: *.
Rv0592|M.tuberculosis_H37Rv ERLRPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTAN
Mb0607|M.bovis_AF2122/97 ERLRPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTAN
MAV_4548|M.avium_104 ERLRPPPGYKDTTVPGIFARDTPFSHGNHEPGWVVAPGMQGIDVQPFTAG
Mflv_0708|M.gilvum_PYR-GCK ERLRPPPGYKDTTVPGIFSRDTLFSHGNHEPAWVVAPGMQGVEVQPFTRN
Mvan_0137|M.vanbaalenii_PYR-1 ERLRPPPGYKDTTVPGIFSRDTLFSHGNHEPGWVVAPGMQGVEVQPFTQN
MSMEG_0137|M.smegmatis_MC2_155 KRLQPPPGYKDTTVPGIWSRDTLFSHGNHEPGWIVAPGMQGVQVQPATAN
TH_3020|M.thermoresistible__bu PRLQPPPGYKDTTVPGIWSRDTLFSHGNHEPGWIVAPGMQGIQVX-----
MMAR_0415|M.marinum_M PRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAG
MUL_1065|M.ulcerans_Agy99 PRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAG
MLBr_02592|M.leprae_Br4923 ARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAA
MAB_4150c|M.abscessus_ATCC_199 PETEAKSQAPREDLVWVRPNGAPPPPK-----------------------
. .. : : .: .
Rv0592|M.tuberculosis_H37Rv MLTPESLAELLGGPDIAPPPPG--------TNLPGPPNAYDESNPLPPPW
Mb0607|M.bovis_AF2122/97 MLTPESLAELLGGPDIAPPAAG--------NQLARTAECV----------
MAV_4548|M.avium_104 MLTPESLAELMGGPDAAPPPPG--------VTAAGPPNAYDESNPPSPPW
Mflv_0708|M.gilvum_PYR-GCK MLTPESLSELMGGPDVAPPPAPPAFGTTRNGNLPGPPNAFDQNNPLPPPW
Mvan_0137|M.vanbaalenii_PYR-1 MLTPESLAELMGGPDIVPPPAPPAFGTTRNGNLPGPPNAFDQNNPLPPPW
MSMEG_0137|M.smegmatis_MC2_155 MLTPESLAELLGGPDIVPPPAPPAFGTTRGGNLPGPPNAFDENNPLPPPW
TH_3020|M.thermoresistible__bu ------------------XXAWDACRSTGSTSKIGSCSALRSRS------
MMAR_0415|M.marinum_M LMTPESLSELMGGPDIEPVQST-------LQTPPGPPNAYDEYPVLPPIG
MUL_1065|M.ulcerans_Agy99 LMTPESLSELMGGPDIEPVQST-------LQTPPGPPNAYDEYPVLPPIG
MLBr_02592|M.leprae_Br4923 LMTPDSLAELMGGPDIEPIQSN-------LQTPPGPPTAYDEHPVPPPIG
MAB_4150c|M.abscessus_ATCC_199 -PSPQDLSALMLGPDEVNAPPP-----------PGTEVRPAEPGPVPPGF
. .
Rv0592|M.tuberculosis_H37Rv YPQPASL--PAAGATGQPGPGQ----------------------------
Mb0607|M.bovis_AF2122/97 --------------------------------------------------
MAV_4548|M.avium_104 FSRPT-----------PPGPGR----------------------------
Mflv_0708|M.gilvum_PYR-GCK YPQPGPP--PAPAPGVVPGNPAPVNAPAP--AAPAPAAPSGPLLPAEAGG
Mvan_0137|M.vanbaalenii_PYR-1 YPQPGPP--PAPAPGVVQGNPLGAIAPAAPPAGPAPAAPSGPLLPAEAGG
MSMEG_0137|M.smegmatis_MC2_155 YPQPGPP--PAPAPGVIPGDPLSAVAPAAP-AAPAAPAPAGPPLPAEAGA
TH_3020|M.thermoresistible__bu --SSSAS--SSTVRVRLASNSSRCLVNR----------------------
MMAR_0415|M.marinum_M LQAPVPIQPPPPGPEVIPGPVAPTPAPGPAPAPVG------APLPAEAGA
MUL_1065|M.ulcerans_Agy99 LQAPVPIQPPPPGPEVIPGPVAPTPAPGPAPAPVG------APLPAEAGA
MLBr_02592|M.leprae_Br4923 LQASVPI--PSPRPDVVPGPVAPTPSP---AANVGD-----PPLPAELGA
MAB_4150c|M.abscessus_ATCC_199 PVTADDAP-----PPAIPGAPR----------------------------
Rv0592|M.tuberculosis_H37Rv --
Mb0607|M.bovis_AF2122/97 --
MAV_4548|M.avium_104 --
Mflv_0708|M.gilvum_PYR-GCK TR
Mvan_0137|M.vanbaalenii_PYR-1 --
MSMEG_0137|M.smegmatis_MC2_155 G-
TH_3020|M.thermoresistible__bu --
MMAR_0415|M.marinum_M GQ
MUL_1065|M.ulcerans_Agy99 GQ
MLBr_02592|M.leprae_Br4923 GQ
MAB_4150c|M.abscessus_ATCC_199 --