For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLTNNTVVAYFTQANALYVGDKVQIMGL PVGSIDKIEPAGDKMKVTFHYQNKYKVPANASAVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQ VPTEWDELRDSVSHIIDELGPTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALNALNEGRGDFF AVVRSLALFVNALHQDDQQFVALNKNLAEFTDRLTHSDADLSNAIQQFDSLLAVARPFFAKNREVLTHDV NNLATVTTTLLQPDPLDGLETVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFANPMEFICSSIQAGSRL GYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSEPRLQPPNGYKDTTVPGIWVPDTPL SHRNTQPGWVVAPGMQGVQVGPITQGLLTPESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGL QAPQVPIPPPPPGPDVIPGPVPPTPAPVGAPLPAEAGGGQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0172 | mce1D | - | 100% (530) | MCE-FAMILY PROTEIN MCE1D |
| M. tuberculosis H37Rv | Rv0592 | mce2D | 0.0 | 68.16% (512) | MCE-family protein MCE2D |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-80 | 39.38% (419) | MCE-family protein MCE3D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0178 | mce1D | 0.0 | 100.00% (530) | MCE-family protein MCE1D |
| M. gilvum PYR-GCK | Mflv_0708 | - | 0.0 | 61.93% (549) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02592 | mce1D | 0.0 | 77.53% (534) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 4e-59 | 30.63% (480) | MCE-family protein |
| M. marinum M | MMAR_0415 | mce1D | 0.0 | 81.16% (536) | MCE-family protein Mce1D |
| M. avium 104 | MAV_5012 | - | 0.0 | 79.74% (538) | mce-family protein mce1d |
| M. smegmatis MC2 155 | MSMEG_0137 | - | 0.0 | 64.18% (550) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3020 | - | 0.0 | 68.18% (440) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1065 | mce1D | 0.0 | 80.97% (536) | MCE-family protein Mce1D |
| M. vanbaalenii PYR-1 | Mvan_0137 | - | 0.0 | 63.44% (547) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0708|M.gilvum_PYR-GCK MSTIFNVRNMKGPGLSRG-LIIGAVVLVLVVVGAFLGMKLYKQMTTKTVV
Mvan_0137|M.vanbaalenii_PYR-1 MSTVFNVRNLKSPGASRATLIIGVIVVVLAVVGAVLGWNLYKQMTTKTVV
MSMEG_0137|M.smegmatis_MC2_155 MSTIFNIRNIQLPRLSRAAVIIGALVVAAALVAGYFGMNAYRKLTNTTVT
TH_3020|M.thermoresistible__bu MSTIFNVRNLRLPRLSRTAVILGALVVALALVAAVVGYQLYKRITTNTAV
Rv0172|M.tuberculosis_H37Rv MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLTNNTVV
Mb0178|M.bovis_AF2122/97 MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLTNNTVV
MMAR_0415|M.marinum_M MSTIFDIRNIRLPKVSRATVIIGSLVLVLGLVAAFVGLKLYQKLTNNTVV
MUL_1065|M.ulcerans_Agy99 MSTIFDIRNIRLPEVSRATVIIGSLVLVLGLVAAFVGLKLYQKLTNNTVV
MAV_5012|M.avium_104 MSTIFDIRNIRLPKLSRTSVILGALVIVLALVVGYVGWRLYEKLTNNTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
*: : * ..: . . : . . .
Mflv_0708|M.gilvum_PYR-GCK AYFTQTLAIYPGDKVQIMGVQVGAIDKIEPAGDKMKVTFHYEDKYRVPEN
Mvan_0137|M.vanbaalenii_PYR-1 AYFTQTLAIYPGDKVQIMGVQVGSIDKIEPAGDKMKVTFHYAGKYKVPQD
MSMEG_0137|M.smegmatis_MC2_155 AYFPEVLALYPGDKVLIMGVRVGSIDSIETAGDKMKVVFHFNNKYKVPEN
TH_3020|M.thermoresistible__bu AYFEQTLALYPGDKVQIMGVHVGNIDTIEPAGDKMKVTFHYDSKYKLPSD
Rv0172|M.tuberculosis_H37Rv AYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPAN
Mb0178|M.bovis_AF2122/97 AYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPAN
MMAR_0415|M.marinum_M AYFPSANALYPGDKVQIMGLQVGKIDNIEPAGDKMKVTFHYQNKYKVPAN
MUL_1065|M.ulcerans_Agy99 AYFPSANALYPGDKVQIMGLQVGKIDNIEPAGDKMKVTFHYQNKYKVPAN
MAV_5012|M.avium_104 AYFPAANALYPGDKVQIMGLRVGAIDKIEPSGDKMKVTFHYQNKYRVPAN
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* . .:* **.* *:*: .* *. : . ..:**.:. .*:::* .
Mflv_0708|M.gilvum_PYR-GCK ATASILNPSLVASRTIQLSPAYTGGNTLPDNAVLDIDRTQVPVEYDDLRD
Mvan_0137|M.vanbaalenii_PYR-1 ATASILNPSLVASRTIQLSPPYTGGPVLADGAVLDVDRTQVPVEYDDVRD
MSMEG_0137|M.smegmatis_MC2_155 ATASILNPSLVASRVIQLSPPYTGGPTLRDGAVLDVDRTQVPIEYDEVRN
TH_3020|M.thermoresistible__bu VSASILNPSLVASRSIQLSPPYTGGDTFPDGGVIPIERTQVPVEWDELRN
Rv0172|M.tuberculosis_H37Rv ASAVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRD
Mb0178|M.bovis_AF2122/97 ASAVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRD
MMAR_0415|M.marinum_M ASAVILNPTLVASRTIQLEPPYKGGPVLADNAVIPLERTQVPVEWDELRN
MUL_1065|M.ulcerans_Agy99 ASAVILNPTLVASRTIQLEPPYKGGPVLADNAVIPLERTQVPVEWDELRN
MAV_5012|M.avium_104 ASAVILNPTLVASRAIQLEPPYKGGPVLADNAVIPEERTQVPVEWDQLRN
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: *.**::* :** *.* .* .: *.. : ::* ** *:*:::
Mflv_0708|M.gilvum_PYR-GCK SISRLLTDLGPTPEQPKGPFGDIIESAADGFAGKGKQLNSTLNNLSEALF
Mvan_0137|M.vanbaalenii_PYR-1 SISRLLTDLGPTPEQPKGPFGDIIESAADGFAGKGEQLNKTLNNLSEALF
MSMEG_0137|M.smegmatis_MC2_155 QVTRLLADLGPTPEQPKGPFGDIIESFADGFAGKGEQLNRTLRGLSDALT
TH_3020|M.thermoresistible__bu SIDRILTDLGPTDEQPMGPFGDVVDSFADGLAGKGQQINQTLTSLSEALT
Rv0172|M.tuberculosis_H37Rv SVSHIIDELGPTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALN
Mb0178|M.bovis_AF2122/97 SVSHIIDELGPTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALN
MMAR_0415|M.marinum_M SITNIIDKLGPTKDQPTGPFGEVLESFANGLEGKGKQINTTLDSLSRALT
MUL_1065|M.ulcerans_Agy99 SITNIIDKLGPTKDQPTGPFGEVLESFANGLEGKGKQINTTLDSLSRALI
MAV_5012|M.avium_104 SITNIISKLGPTAEQPKGPFGEVIESFADGLAGKGKQFNTTLTNLSRALT
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQ-GQSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: .: .*** *. **..:.:: * : *:*..:. :: ** *
Mflv_0708|M.gilvum_PYR-GCK ALNEGRGDFFSVVKSLATFVNALHQSDQQFVALNNDLAQFTNAFTDSDRE
Mvan_0137|M.vanbaalenii_PYR-1 ALNEGRGDFFSVVKSLALFVNALHQSDQQFVALNNNLAQFTNAFTDTDRE
MSMEG_0137|M.smegmatis_MC2_155 ALNEGRGDFFAVVKSLALFVNALHRSDQQFVALNNDLAQFTNSFTNTDQE
TH_3020|M.thermoresistible__bu ALNEGRGDFFGVVKSLALFVNALHRSDQQFVALNRDLAQFTTSFANTDQE
Rv0172|M.tuberculosis_H37Rv ALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNKNLAEFTDRLTHSDAD
Mb0178|M.bovis_AF2122/97 ALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNKNLAEFTDRLTHSDAD
MMAR_0415|M.marinum_M ALNEGRGDFFAVVRSLALFVNALHQDDKQFVALNQNLADVTGRLVGYDRD
MUL_1065|M.ulcerans_Agy99 ALNEGRGDFFAVVRSLALFVNALHQDDKQFVALNQNLADVTGRLVGYDRD
MAV_5012|M.avium_104 ALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNQNLADFTTRLAHSDGD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
*.:.* *:*..::.* :*:** .::*:* :. .**..: :. :
Mflv_0708|M.gilvum_PYR-GCK VANALQDLDELLTTTRGFIDENGEVLAHDVQNLAEVTNAILQPEPLDGLE
Mvan_0137|M.vanbaalenii_PYR-1 VADALRDLNELLTTTRNFVDENGEVLAHDVQNLADVTNAILQPEPRDGLE
MSMEG_0137|M.smegmatis_MC2_155 LANALQDLNRVLKTTREFLDRNGGVLTHDIDNLEQVTTAILQPEPRDGLE
TH_3020|M.thermoresistible__bu LANAVRDLDELLTTTRQFLDENAEVLTYDINNLAEVTNAILQPEPLDGLE
Rv0172|M.tuberculosis_H37Rv LSNAIQQFDSLLAVARPFFAKNREVLTHDVNNLATVTTTLLQPDPLDGLE
Mb0178|M.bovis_AF2122/97 LSNAIQQFDSLLAVARPFFAKNREVLTHDVNNLATVTTTLLQPDPLDGLE
MMAR_0415|M.marinum_M LSNALQQFDSLLSTVRPFLDKNREVLTYDVNNLAEATNTLLQPDPLNGLE
MUL_1065|M.ulcerans_Agy99 LSNALQQFDSLLSTVRPFLDKNREVLTYDVNNLAEATNTLLQPDPLNGLE
MAV_5012|M.avium_104 LANAIEQFDSLLTTVRPWLDKNRGVLTYDVKNLETATNALLQPDPLNGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFS--DQSDDLE
:. :: :: * .: :. . .* ::.:* . . : :.:*
Mflv_0708|M.gilvum_PYR-GCK TALHAYPNVAANLMNISSPNAGGIVTMPVIS---NFANPMQFLCS-AIQA
Mvan_0137|M.vanbaalenii_PYR-1 TALHAYPNVAANLMNISSPNAGGIVTMPVIS---NFANPMQFLCS-AIQA
MSMEG_0137|M.smegmatis_MC2_155 TGLHAYPNLAANVLNINSPNQGGIIGLPVLPGVTNFSNPLQFVCS-SIQA
TH_3020|M.thermoresistible__bu TALHVFPTMGANIMNISSPNSGGIVSLPVVT---NFANPLQFICS-AIQA
Rv0172|M.tuberculosis_H37Rv TVLHIFPTLAANINQLYHPTHGGVVSLSAFT---NFANPMEFICS-SIQA
Mb0178|M.bovis_AF2122/97 TVLHIFPTLAANINQLYHPTHGGVVSLSAFT---NFANPMEFICS-SIQA
MMAR_0415|M.marinum_M TALHVLPTAASNVNQIYHPAHGSVVAVPEIT---SFANPMQFVCS-SIQA
MUL_1065|M.ulcerans_Agy99 TALHVLPTAASNVNHIYHPAHGSVVAVPEIT---SFANPMQFVCS-SIQA
MAV_5012|M.avium_104 TALHVLPTAAANINQIYHPSHGSVVAIPSIT---NFANPMQFICS-AIQA
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTIT---NFANPMQFICS-AIQA
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIP---NLANPVQFICGGVFET
** *. :*. :: * * : : .. .::**::*:*. :::
Mflv_0708|M.gilvum_PYR-GCK GSRLGYQESAELCAQYLGPILDAIKFNYLPFGANQLQTAMTLPKQISYSE
Mvan_0137|M.vanbaalenii_PYR-1 GSRLGYQESAELCAQYLGPILDAIKFNYLPFGANQLQTAMTLPKQIAYSE
MSMEG_0137|M.smegmatis_MC2_155 GSRLGYQESAELCAQYLAPIMDAIKFNYLPFGMNLASTAMTLPKQIAYSE
TH_3020|M.thermoresistible__bu GSRLGYQESAELCAEYLAPILDAIKFNFPPFGFNQITTASVLPKQVAYSE
Rv0172|M.tuberculosis_H37Rv GSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSE
Mb0178|M.bovis_AF2122/97 GSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSE
MMAR_0415|M.marinum_M GSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNAFNTAEVLPKQVAYSE
MUL_1065|M.ulcerans_Agy99 GSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNAFNTAEVLPKQVAYSE
MAV_5012|M.avium_104 GSRLGYQESAELCAQYLAPILDAIKFNYPPFGLNLFSTAETLPKEVAYSE
MLBr_02592|M.leprae_Br4923 GSRLGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSE
MAB_4150c|M.abscessus_ATCC_199 GTKTEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDT
*:: * : **:* : :.*:: .**: *: : . :: *.
Mflv_0708|M.gilvum_PYR-GCK ERLRPPPGYKDTTVPGIFSRDTLFSHGNHEPAWVVAPGMQGVEVQPFTRN
Mvan_0137|M.vanbaalenii_PYR-1 ERLRPPPGYKDTTVPGIFSRDTLFSHGNHEPGWVVAPGMQGVEVQPFTQN
MSMEG_0137|M.smegmatis_MC2_155 KRLQPPPGYKDTTVPGIWSRDTLFSHGNHEPGWIVAPGMQGVQVQPATAN
TH_3020|M.thermoresistible__bu PRLQPPPGYKDTTVPGIWSRDTLFSHGNHEPGWIVAPGMQGIQVX-----
Rv0172|M.tuberculosis_H37Rv PRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQG
Mb0178|M.bovis_AF2122/97 PRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQG
MMAR_0415|M.marinum_M PRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAG
MUL_1065|M.ulcerans_Agy99 PRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAG
MAV_5012|M.avium_104 PRLQPPNGYKDTTVPGIWVPDTPTSHRNTQPGWIVAPGMQGQQVGPITAG
MLBr_02592|M.leprae_Br4923 ARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAA
MAB_4150c|M.abscessus_ATCC_199 PETEAKSQAPREDLVWVRPNGAPPPPK-----------------------
. .. : : .: .
Mflv_0708|M.gilvum_PYR-GCK MLTPESLSELMGGPDVAPPPAPPAFGTTRNGNLPGPPNAFDQNNPLPPP-
Mvan_0137|M.vanbaalenii_PYR-1 MLTPESLAELMGGPDIVPPPAPPAFGTTRNGNLPGPPNAFDQNNPLPPP-
MSMEG_0137|M.smegmatis_MC2_155 MLTPESLAELLGGPDIVPPPAPPAFGTTRGGNLPGPPNAFDENNPLPPP-
TH_3020|M.thermoresistible__bu ------------------XXAWDACRSTGSTSKIGSCSALRSRS------
Rv0172|M.tuberculosis_H37Rv LLTPESLAELMGGPDIAPPSSG-------LQTPPGPPNAYDEYPVLPPIG
Mb0178|M.bovis_AF2122/97 LLTPESLAELMGGPDIAPPSSG-------LQTPPGPPNAYDEYPVLPPIG
MMAR_0415|M.marinum_M LMTPESLSELMGGPDIEPVQST-------LQTPPGPPNAYDEYPVLPPIG
MUL_1065|M.ulcerans_Agy99 LMTPESLSELMGGPDIEPVQST-------LQTPPGPPNAYDEYPVLPPIG
MAV_5012|M.avium_104 LMTPDSLEELMGGPNIAPVQSN-------LQTPPGPPNAYDENPILPPMG
MLBr_02592|M.leprae_Br4923 LMTPDSLAELMGGPDIEPIQSN-------LQTPPGPPTAYDEHPVPPPIG
MAB_4150c|M.abscessus_ATCC_199 -PSPQDLSALMLGPDEVNAPPP-----------PGTEVRPAEPGPVPPG-
. *. .
Mflv_0708|M.gilvum_PYR-GCK --WYPQPGPPPAPAPGVVPGNPAPVNAPAP--AAPAPAAPSGPLLPAEAG
Mvan_0137|M.vanbaalenii_PYR-1 --WYPQPGPPPAPAPGVVQGNPLGAIAPAAPPAGPAPAAPSGPLLPAEAG
MSMEG_0137|M.smegmatis_MC2_155 --WYPQPGPPPAPAPGVIPGDPLSAVAPAAP-AAPAAPAPAGPPLPAEAG
TH_3020|M.thermoresistible__bu -----SSSASSSTVRVRLASNSSRCLVNR---------------------
Rv0172|M.tuberculosis_H37Rv LQAPQVPIPPPPPGPDVIPGPVPPTPAPVG------------APLPAEAG
Mb0178|M.bovis_AF2122/97 LQAPQVPIPPPPPGPDVIPGPVPPTPAPVG------------APLPAEAG
MMAR_0415|M.marinum_M LQAP-VPIQPPPPGPEVIPGPVAPTPAPGPAPAP------VGAPLPAEAG
MUL_1065|M.ulcerans_Agy99 LQAP-VPIQPPPPGPEVIPGPVAPTPAPGPAPAP------VGAPLPAEAG
MAV_5012|M.avium_104 LNAP-VPIPPPPPGPGVAPGPVAPTPAPVSAPAPNA----GGPAAPADFG
MLBr_02592|M.leprae_Br4923 LQAS-VPIPS--PRPDVVPGPVAPTPSPAANVGD--------PPLPAELG
MAB_4150c|M.abscessus_ATCC_199 -----FPVTADDAPPPAIPGAPR---------------------------
. . . .
Mflv_0708|M.gilvum_PYR-GCK GTR
Mvan_0137|M.vanbaalenii_PYR-1 G--
MSMEG_0137|M.smegmatis_MC2_155 AG-
TH_3020|M.thermoresistible__bu ---
Rv0172|M.tuberculosis_H37Rv GGQ
Mb0178|M.bovis_AF2122/97 GGQ
MMAR_0415|M.marinum_M AGQ
MUL_1065|M.ulcerans_Agy99 AGQ
MAV_5012|M.avium_104 GGQ
MLBr_02592|M.leprae_Br4923 AGQ
MAB_4150c|M.abscessus_ATCC_199 ---