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TTRLRRTRSVLATTLILVLVAGVIAAMRTAGDATRTLVVAYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQ PLRSKISFWFDRKYKVPADAKAAILSPQLVTGRAIQLTPPYSGGPTTASGAIISQQRTAVPVEWDDLRNQ LQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVSTLSDHRNDIFSTVRNLSTLVS ALHDSADLLEQLNHNLAAVSSLLATDPNKVGQAVKDINAVVADVQSFAAEYREAVGTASDKLASISNALV ASLDDIKQTLHIGPTVLQNLNNIFEPANGALTGALAANDFANPISFLCGAIQSASRLGGEQAAKLCVQYL APILKNRQYNFPPLGENLFVGAQARPNEVTYGEDWMRPDYVPPQPDMPPAEPPADVTVEPDPAAGLRGMM VPPGGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2867 | mce3D | - | 100% (427) | MCE-family protein Mce3D |
| M. ulcerans Agy99 | MUL_3921 | mce3D_1 | e-155 | 61.90% (441) | MCE-family protein Mce3D_1 |
| M. ulcerans Agy99 | MUL_1065 | mce1D | 4e-76 | 37.18% (425) | MCE-family protein Mce1D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0178 | mce1D | 3e-77 | 36.13% (429) | MCE-family protein MCE1D |
| M. gilvum PYR-GCK | Mflv_0649 | - | 1e-152 | 61.63% (443) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 0.0 | 81.97% (427) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 2e-77 | 36.28% (430) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 1e-63 | 33.17% (413) | MCE-family protein |
| M. marinum M | MMAR_2885 | mce3D | 0.0 | 98.59% (427) | MCE-family protein Mce3D |
| M. avium 104 | MAV_2535 | - | 1e-157 | 62.56% (438) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 1e-157 | 62.88% (431) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4580 | - | 1e-157 | 66.35% (416) | PUTATIVE putative transcriptional regulator, AraC family |
| M. vanbaalenii PYR-1 | Mvan_3979 | - | 1e-169 | 67.92% (427) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0178|M.bovis_AF2122/97 MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLTNNTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MUL_2867|M.ulcerans_Agy99 ----------MTTRLRRTRSVLATTLILVLVAGVIAAMRTAGDATRTLVV
MMAR_2885|M.marinum_M ----------MTTRLRRTRSVLATTLILVLVAGVIAAMRTAGDATRTLVV
Rv1969|M.tuberculosis_H37Rv ----------MTTKLRRARSVLAT--ALVLVAGVILAMRTADAAARTTVV
Mvan_3979|M.vanbaalenii_PYR-1 ----------MSARLRRARGGLAAVLVLTLAAGFLVAARAADHVERIWVT
MSMEG_0349|M.smegmatis_MC2_155 ------------MRISKKQLTLAAGLVVVMVAGVLVGFRMTGPAARTTIT
TH_4580|M.thermoresistible__bu ---------------------VAVALIVVLFAGIVGTVRLAQQGSRMTVV
Mflv_0649|M.gilvum_PYR-GCK ------------MTNSRTKLGLAIILVSLVVGGAIAVTRAAHELDRVHVV
MAV_2535|M.avium_104 ---------------------MAIALTAVLLGGIVTVVRSAAGVGRTTVV
MAB_4150c|M.abscessus_ATCC_199 ----------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSR--GTYKIV
. :.
Mb0178|M.bovis_AF2122/97 AYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPAN
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MUL_2867|M.ulcerans_Agy99 AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRSKISFWFDRKYKVPAD
MMAR_2885|M.marinum_M AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRSKISFWFDRKYKVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
Mvan_3979|M.vanbaalenii_PYR-1 AYFENSNGLFAGDDVRILGVPVGRVDSIRPEPTRARITFWVDRRYPVPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
TH_4580|M.thermoresistible__bu AYFENTTGVFPGDDVRILGVRVGQISAIEPQPDRVKVTFWVDERYPVPAE
Mflv_0649|M.gilvum_PYR-GCK AYFDNSNGVFVGDDVRIKGVRVGRIEAIEPQPTQVRITFWFDAKYPVPAD
MAV_2535|M.avium_104 GYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWLNDKYKVPAD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* : .:: **.* * *: .* : : * :::: .: **
Mb0178|M.bovis_AF2122/97 ASAVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MUL_2867|M.ulcerans_Agy99 AKAAILSPQLVTGRAIQLTPPYSGGPTTASGAIISQQRTAVPVEWDDLRN
MMAR_2885|M.marinum_M AKAAILSPQLVTGRAIQLTPPYSGGPTMASGAIISQQRTAVPVEWDDLRN
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
Mvan_3979|M.vanbaalenii_PYR-1 AKAVILSPQLVTGRAIQLTPAYTGGPVMPTGTVVGQERTAVPVEWDDVRV
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
TH_4580|M.thermoresistible__bu VNAVILSPQLVTGRAIQLTPAYTSGPMLADGAEIPLARTAVPVEWDDVRE
Mflv_0649|M.gilvum_PYR-GCK AKAVILSPTLVTSRAIQLTPGYTGGPTLQNNATIPRARTAVPVEFDEFRQ
MAV_2535|M.avium_104 VKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQ
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: * **: * :** * * .* : : :* ** .:*:.:
Mb0178|M.bovis_AF2122/97 SVSHIIDELGPTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALN
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MUL_2867|M.ulcerans_Agy99 QLQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVS
MMAR_2885|M.marinum_M QLQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
Mvan_3979|M.vanbaalenii_PYR-1 QLQRLTKLLRPTEPGGVSTLGAFINTTADNLRGQGANIRQTVVKLSQALA
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
TH_4580|M.thermoresistible__bu QLARVTQLLQPTAPGEPSTLGRAIDTAADNLRGQGPTIRDTIVRLSRAMS
Mflv_0649|M.gilvum_PYR-GCK QLERLTALLQPTEPGEVSTLGSLVNTAADNLRGQGPAIRDAIIRLSQSVS
MAV_2535|M.avium_104 QLEKLTQVLQPTAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAIS
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQG-QSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: :: * * .... :: * : *:* :. :: **::
Mb0178|M.bovis_AF2122/97 ALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNKNLAEFTDRLTHSDAD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MUL_2867|M.ulcerans_Agy99 TLSDHRNDIFSTVRNLSTLVSALHDSADLLEQLNHNLAAVSSLLATDPNK
MMAR_2885|M.marinum_M TLSDHRNDIFSTVRNLSTLVSALHDSADLLEQLNHNLAAVSSLLATDPNK
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
Mvan_3979|M.vanbaalenii_PYR-1 ILGDHSDDIFTTFTNLSTLVSALHDSADLLEQLNQNMAAVTSLIADDPQK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
TH_4580|M.thermoresistible__bu ALGDHSQDVFGSLRNLSTLVSALHDSTGLLEQLNHNMAAVSALLAEDPDK
Mflv_0649|M.gilvum_PYR-GCK ALADHSPDIFTSVRNLSTLVSALQDSTVLIRQLNQNLASVTGLLANEPTE
MAV_2535|M.avium_104 ALGDHSNDLFSTVKNLSILVSALHDSSDLLQQLNQNLAEVTGLLANDPNE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
: : *.* . .* :* ** . : :. ::* .: :: .
Mb0178|M.bovis_AF2122/97 LSNAIQQFDSLLAVARPFFAKNREVLTHDVNNLATVTTTLLQPDPLDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MUL_2867|M.ulcerans_Agy99 VGQAVKDINAVVADVQSFAAEYREAVGTASDKLASISNALVAS--LDDIK
MMAR_2885|M.marinum_M VGQAVEDINAVVADVQSFAAENREAVGTASDKLASISNALVAS--LDDIK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVDS--LDDIK
Mvan_3979|M.vanbaalenii_PYR-1 VARTVQDLGGVIGDVKEFADDNREAIGTATDTLASVSTALVDS--LDDLK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALVQS--LDDIK
TH_4580|M.thermoresistible__bu VGRVVADLHALVGDLQQFVADNREPLEIASTRLDSVGTALVDS--IDDIK
Mflv_0649|M.gilvum_PYR-GCK VGDAVKNLNDVVGEVTAFVAANRDTIGATSDKLTSVSQALTDS--TDDIE
MAV_2535|M.avium_104 VANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVTDS--LGDVK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQ--SDDLE
:. . : * .. : . . ..::
Mb0178|M.bovis_AF2122/97 TVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFANPMEFICS-SIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
MUL_2867|M.ulcerans_Agy99 QTLHIGPTVLQNLNNIFEPANGALTGALAANDFANPISFLCG-AIQSASR
MMAR_2885|M.marinum_M QTLHIGPTVLQNFNNIFEPANGALTGALAANDFANPISFLCG-AIQSASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
Mvan_3979|M.vanbaalenii_PYR-1 QTLHIAPGTVANFHNIFEPANGSLTGALAVNNFANPISFICG-AIQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
TH_4580|M.thermoresistible__bu QALHVAPTVLQNFSNIYEAANGSFTGALAANNFANPIQFLCG-AVQAASR
Mflv_0649|M.gilvum_PYR-GCK QLLHIAPTTLSNAANLYQSAQGTLTGALNVANFSDPITFLCG-AVQAASR
MAV_2535|M.avium_104 QLLHTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCG-AVEAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
** * * :::..: * . . ::::.: *:*. .::.::
Mb0178|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSEPRL
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSEARL
MUL_2867|M.ulcerans_Agy99 LGGEQAAKLCVQYLAPILKNRQYNFPPLGENLFVGAQARPNEVTYGEDWM
MMAR_2885|M.marinum_M LGGEQAAKLCVQYLAPILKNRQYNFPPLGENLFVGAQARPNEVTYSEDWM
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWL
Mvan_3979|M.vanbaalenii_PYR-1 HGAEQSAKLCAQYLAPIVKNRQYNFPPIGENLLVGTQARPNEVTYSEDWL
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWL
TH_4580|M.thermoresistible__bu LGAEQAAKLCVQYLAPIVKNRQYNFPPLGLNLFVGAQARPNEVTYSEPWM
Mflv_0649|M.gilvum_PYR-GCK LNNEQSAKLCVQYLAPIIKNRQYNFPPIGVNPFVGATVRPNEVTYSEDWM
MAV_2535|M.avium_104 LGAKESAKLCVQYLAPIIKNRQVNFPPLGENLFVGAAARPNELTYSEDWL
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. *::* : :.*:: *: *: : . :: :.
Mb0178|M.bovis_AF2122/97 QPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLT
MLBr_02592|M.leprae_Br4923 QPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAALMT
MUL_2867|M.ulcerans_Agy99 RP-----DYVPPQP----------------------DMPPAEPPADVTVE
MMAR_2885|M.marinum_M RP-----DYVPPQP----------------------DMPPAERPADVTVE
Rv1969|M.tuberculosis_H37Rv RP-----DYVAPVA----------------------DTPP-DPAAAVTVD
Mvan_3979|M.vanbaalenii_PYR-1 RP-----DFVPP------------------------AAPPADQPQAVAVD
MSMEG_0349|M.smegmatis_MC2_155 RP-----DYIPPAQPVTQDL-------------DPEVLPAEAAPTDGSAD
TH_4580|M.thermoresistible__bu RP-----DYVPPLP---------------------AEAAPAASPHGTTVA
Mflv_0649|M.gilvum_PYR-GCK RP-----DYVPPQPTLPAATGADPDAPPPLTGPTLPAEAPVPMPDPSNRQ
MAV_2535|M.avium_104 RP-----DYVPPHPDSPPTGDAPAPPAAGATPAEAPPPAADAPPPAQAAP
MAB_4150c|M.abscessus_ATCC_199 EA-----KSQAPRED------------------LVWVRPNGAPPPPKPSP
.. . *
Mb0178|M.bovis_AF2122/97 PESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPP
MLBr_02592|M.leprae_Br4923 PDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQAS-VPIPS
MUL_2867|M.ulcerans_Agy99 PDPAAGLRG----------MMVPPGGG-----------------------
MMAR_2885|M.marinum_M PDPAAGLRG----------MMVPPGGG-----------------------
Rv1969|M.tuberculosis_H37Rv P--ATGLRG----------MMMPPGGGS----------------------
Mvan_3979|M.vanbaalenii_PYR-1 P--DAGLQG----------MMVPAGGGVS---------------------
MSMEG_0349|M.smegmatis_MC2_155 P--SAGLPG----------LMIPTEAGS----------------------
TH_4580|M.thermoresistible__bu ADPAAGLPG----------LLLPHGGDR----------------------
Mflv_0649|M.gilvum_PYR-GCK TDPAAGLPG----------MMIPHGGGS----------------------
MAV_2535|M.avium_104 TNPAEGLRG----------MMMPPGGGQ----------------------
MAB_4150c|M.abscessus_ATCC_199 QDLSALMLG-------PDEVNAPPPPGTEVRPAEPGP--------VPPGF
: * : *
Mb0178|M.bovis_AF2122/97 PPPGPDVIPGPVPPTPAPVG----APLPAEAGGGQ
MLBr_02592|M.leprae_Br4923 P--RPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
MUL_2867|M.ulcerans_Agy99 -----------------------------------
MMAR_2885|M.marinum_M -----------------------------------
Rv1969|M.tuberculosis_H37Rv -----------------------------------
Mvan_3979|M.vanbaalenii_PYR-1 -----------------------------------
MSMEG_0349|M.smegmatis_MC2_155 -----------------------------------
TH_4580|M.thermoresistible__bu -----------------------------------
Mflv_0649|M.gilvum_PYR-GCK -----------------------------------
MAV_2535|M.avium_104 -----------------------------------
MAB_4150c|M.abscessus_ATCC_199 PVTADDAPPPAIPGAPR------------------