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VAIALTAVLLGGIVTVVRSAAGVGRTTVVGYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWL NDKYKVPADVKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQQLEKLTQVLQP TAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAISALGDHSNDLFSTVKNLSILVSALHDSSDLLQ QLNQNLAEVTGLLANDPNEVANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVTDSLGDVKQLL HTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCGAVEAASRLGAKESAKLCVQYLAPIIKNRQVN FPPLGENLFVGAAARPNELTYSEDWLRPDYVPPHPDSPPTGDAPAPPAAGATPAEAPPPAADAPPPAQAA PTNPAEGLRGMMMPPGGGQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2535 | - | - | 100% (439) | virulence factor mce family protein |
| M. avium 104 | MAV_2064 | - | e-134 | 56.42% (436) | virulence factor mce family protein |
| M. avium 104 | MAV_4548 | - | 9e-83 | 38.35% (485) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0607 | mce2Da | 5e-85 | 40.09% (444) | hypothetical protein Mb0607 |
| M. gilvum PYR-GCK | Mflv_2104 | - | 1e-167 | 65.84% (445) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-157 | 63.07% (436) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 2e-82 | 41.36% (382) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 4e-76 | 37.22% (446) | MCE-family protein |
| M. marinum M | MMAR_4054 | mce3D_1 | 1e-170 | 67.43% (439) | MCE-family protein Mce3D_1 |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 1e-143 | 56.63% (445) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3797 | - | 1e-153 | 62.19% (439) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3921 | mce3D_1 | 1e-170 | 68.34% (439) | MCE-family protein Mce3D_1 |
| M. vanbaalenii PYR-1 | Mvan_4601 | - | 1e-166 | 65.69% (443) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0607|M.bovis_AF2122/97 MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MMAR_4054|M.marinum_M -------------MIRRTKTWLAVLLVGLLAAGVVVLLRTTEVVNRTNVV
MUL_3921|M.ulcerans_Agy99 -------------MIRRTKTWLAVLLVGLLAAGVVVLLRTTEVVNRTNVV
Mvan_4601|M.vanbaalenii_PYR-1 -------------MTRTLRILLIASLSVILVGGVVVLLRTTEAINRTHAV
Mflv_2104|M.gilvum_PYR-GCK --------------MKNLRLWVGLVLVALLVVGVALLVRTTDKVNRVNVV
MAV_2535|M.avium_104 ---------------------MAIALTAVLLGGIVTVVRSAAGVGRTTVV
Rv1969|M.tuberculosis_H37Rv ------------MTTKLRRARSVLATALVLVAGVILAMRTADAAARTTVV
MSMEG_0349|M.smegmatis_MC2_155 ------------MRISKKQLTLAAGLVVVMVAGVLVGFRMTGPAARTTIT
TH_3797|M.thermoresistible__bu ----------VTQLNRHRNIALAAVLVLTLVAGMIILVRMYAASDRVQYT
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
.
Mb0607|M.bovis_AF2122/97 AYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPAT
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MMAR_4054|M.marinum_M AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVKVSFWYDSKYKVPAD
MUL_3921|M.ulcerans_Agy99 AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVRVSFWYDSKYIVPAD
Mvan_4601|M.vanbaalenii_PYR-1 AYFENSNGIYAGDAVSIVGVPVGKIESIEPQPESVKVSFWYDSKYKVPAD
Mflv_2104|M.gilvum_PYR-GCK AYFENSNGIYEGDDVRILGVPVGRITSIEPEPERVKISFWYDDRYDVPAD
MAV_2535|M.avium_104 GYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWLNDKYKVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
TH_3797|M.thermoresistible__bu AYFENSNGVYPGDEVRILGVPVGQIDTVEPEPDRAKITFWVSEKYRVPAD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* : .:: ** * * *: .* : : * :::: .: **
Mb0607|M.bovis_AF2122/97 ATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MMAR_4054|M.marinum_M AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
MUL_3921|M.ulcerans_Agy99 AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
Mvan_4601|M.vanbaalenii_PYR-1 AKAVILSPTLVTARTIQLTPAYTGGPVMENDAVIPRERTAVPVEWDEVRQ
Mflv_2104|M.gilvum_PYR-GCK AAAAILSPALVTARAIQLTPVYTGGPVLGDNAVIPLQRTVVPVEWDQVRA
MAV_2535|M.avium_104 VKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQ
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
TH_3797|M.thermoresistible__bu VRAVILSPQLVTARSIELTPAYTGGPTLQPGEVIPEDRTAVPVEWDDLRE
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: * **: * ::* * * .* : : ::* **:.:*:.:
Mb0607|M.bovis_AF2122/97 SINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALT
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MMAR_4054|M.marinum_M QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
MUL_3921|M.ulcerans_Agy99 QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
Mvan_4601|M.vanbaalenii_PYR-1 QLAKLADTLQPTEPGGVSPLGSVINTTADNLRGEGANIRDTVIKLSQAIS
Mflv_2104|M.gilvum_PYR-GCK QLERLSETLQPTEPGGVSPLGSVINTTAENLRGQGADIRETVIKLSQAFS
MAV_2535|M.avium_104 QLEKLTQVLQPTAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAIS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
TH_3797|M.thermoresistible__bu QLEKLTDALQPTEPGGVSTLGEFINTSAENLRGQGTDIRETVIKLSQAIS
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQG-QSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: : * * .... .*: * : *:* :. :: .**::
Mb0607|M.bovis_AF2122/97 ALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MMAR_4054|M.marinum_M ALGDHSTDIFSTVKNLAILVSALQDSTNFMRQLNQNLATVTGLLANDPNE
MUL_3921|M.ulcerans_Agy99 ALGDHSTDIFSTVKNLAILVSALQDSTNLMRQLNQNLATVTGLLANDPNE
Mvan_4601|M.vanbaalenii_PYR-1 ALGDNSTNIFSTVKNLATLVSALQDSTNLMRQLNQNLASVTGLLANDPDE
Mflv_2104|M.gilvum_PYR-GCK ALGDRSTDIFSTIKNLAILVSALQDSTDLMRQLNQNLASVSGLLTDGPDE
MAV_2535|M.avium_104 ALGDHSNDLFSTVKNLSILVSALHDSSDLLQQLNQNLAEVTGLLANDPNE
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
TH_3797|M.thermoresistible__bu ILGDHSDDLFTSIKNVSLLVSALHDSTDLLRQLNANLAQATGLLTNGPNE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
:.: :.. .: :* ** . : : :. ::* : :: . .
Mb0607|M.bovis_AF2122/97 LADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MMAR_4054|M.marinum_M VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALNDS--LDDVK
MUL_3921|M.ulcerans_Agy99 VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALNDS--LDDVK
Mvan_4601|M.vanbaalenii_PYR-1 VANAVRDLDKAVGEVQTFVADNRESLGTTSDKLAGVTQALTDS--LADVK
Mflv_2104|M.gilvum_PYR-GCK VANAIRDLNAAVGDVQSFVAENRESLGTTSDKLAGVTTALTES--LEDIK
MAV_2535|M.avium_104 VANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVTDS--LGDVK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVDS--LDDIK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALVQS--LDDIK
TH_3797|M.thermoresistible__bu VGQALADLDAAVRDVTDFVADNREAVGTTTNRLASITSALDES--VEEVK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQ--SDDLE
:. : :. * * . .. : : : . : ::
Mb0607|M.bovis_AF2122/97 TALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLICS-AIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
MMAR_4054|M.marinum_M QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
MUL_3921|M.ulcerans_Agy99 QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
Mvan_4601|M.vanbaalenii_PYR-1 QFLHVAPNTLQNYVNIWQPAQGAVSSVPMINNFADPVSFLCG-AVQAASR
Mflv_2104|M.gilvum_PYR-GCK QFLHVAPSTFQNYINIWQPAQGAVSSVPQINNFANPIQFLCG-AVQAASR
MAV_2535|M.avium_104 QLLHTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCG-AVEAASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
TH_3797|M.thermoresistible__bu QALHIAPNTLANFYNIYQPAQAALTGALAVNNFADPVSFLCG-AIQAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
** *. * ::: * .:: . *:::.: ::*. ..::.::
Mb0607|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSEERL
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSEARL
MMAR_4054|M.marinum_M LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSEDWL
MUL_3921|M.ulcerans_Agy99 LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSEDWL
Mvan_4601|M.vanbaalenii_PYR-1 LGAEESAKLCVQYMAPIIKNRQYNFLPLAQNVFVGATTRPNELTYSEDWL
Mflv_2104|M.gilvum_PYR-GCK LGAEESAKLCVQYLAPIIKNRQYNFPPLGLNQLVGATTRPNELTYSEDWL
MAV_2535|M.avium_104 LGAKESAKLCVQYLAPIIKNRQVNFPPLGENLFVGAAARPNELTYSEDWL
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWL
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWL
TH_3797|M.thermoresistible__bu LGAEESSKLCVQYLAPIVKNRQYNFLPFGLNPFVGAAARPNEITYSEDWM
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. :::* : :.*:: *: *: : : . :: :.
Mb0607|M.bovis_AF2122/97 RPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTANMLT
MLBr_02592|M.leprae_Br4923 QPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAALMT
MMAR_4054|M.marinum_M RP-----DYIPPQ------AIPPQAIPPQQAPPAAAPPAQAP--PPAVGP
MUL_3921|M.ulcerans_Agy99 RP-----DYIPPQ------AIP-----PQQAPPAAAPPAQAP--PPAVGL
Mvan_4601|M.vanbaalenii_PYR-1 RP-----DYIPPQPGS--AAPPPPAGAPQPAAGAPQPPAGAPL-PPALGP
Mflv_2104|M.gilvum_PYR-GCK RP-----DYIPPG-----GPAPAPAAGVPTGDPAGLPPGQGP---LLLDA
MAV_2535|M.avium_104 RP-----DYVPPH------PDSPPTGDAPAPPAAGATPAEAP--PPAADA
Rv1969|M.tuberculosis_H37Rv RP-----DYVAPV--------------------ADTPPD------PAAAV
MSMEG_0349|M.smegmatis_MC2_155 RP-----DYIPPA--------------------QPVTQDLDPEVLPAEAA
TH_3797|M.thermoresistible__bu RP-----DYRPMS--------------------LPAPADQS---LPAEEP
MAB_4150c|M.abscessus_ATCC_199 EA-----KSQAPRE---DLVWVRPNGAPPPPKPSPQDLSALMLGPDEVNA
.. .
Mb0607|M.bovis_AF2122/97 PESLAELLGGPDIAPPAAGNQLARTAECV---------------------
MLBr_02592|M.leprae_Br4923 PDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQASVPIPSP
MMAR_4054|M.marinum_M PLPAEA-PATPDPAAGLRGIMVPQGVGS----------------------
MUL_3921|M.ulcerans_Agy99 PLPAEA-PATPDPAAGLRGIMVPQGVGS----------------------
Mvan_4601|M.vanbaalenii_PYR-1 LLPAEAVPTAPNPADGLQGLMVPAGAGS----------------------
Mflv_2104|M.gilvum_PYR-GCK PPGAAEMPVPTNPTDGLHGMMVPPGGGS----------------------
MAV_2535|M.avium_104 PPPAQA--APTNPAEGLRGMMMPPGGGQ----------------------
Rv1969|M.tuberculosis_H37Rv TVD---------PATGLRGMMMPPGGGS----------------------
MSMEG_0349|M.smegmatis_MC2_155 PTDGS-----ADPSAGLPGLMIPTEAGS----------------------
TH_3797|M.thermoresistible__bu VVPAVR---AADPSQGLPGLMIPHGGGR----------------------
MAB_4150c|M.abscessus_ATCC_199 PPPPGTEVRPAEPGPVPPGFPVTADDAPPPAIPGAPR-------------
. .
Mb0607|M.bovis_AF2122/97 --------------------------------
MLBr_02592|M.leprae_Br4923 RPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
MMAR_4054|M.marinum_M --------------------------------
MUL_3921|M.ulcerans_Agy99 --------------------------------
Mvan_4601|M.vanbaalenii_PYR-1 --------------------------------
Mflv_2104|M.gilvum_PYR-GCK --------------------------------
MAV_2535|M.avium_104 --------------------------------
Rv1969|M.tuberculosis_H37Rv --------------------------------
MSMEG_0349|M.smegmatis_MC2_155 --------------------------------
TH_3797|M.thermoresistible__bu --------------------------------
MAB_4150c|M.abscessus_ATCC_199 --------------------------------