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MRISKKQLTLAAGLVVVMVAGVLVGFRMTGPAARTTITAYFANSNGLFAGDDVLILGVPVGKVKEIEPLP ERAKVTFWVDKEFQVPADATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRVQL EKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVTTVSDHKDDVFSTLNNLATLVSA LRDSTDVLAALNRNMAAVSALLADSPDEVGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALVQ SLDDIKQSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICGAIEAASRLGAERSAKLCVQYLA PIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWLRPDYIPPAQPVTQDLDPEVLPAEAAPTDGSADPSA GLPGLMIPTEAGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0349 | - | - | 100% (433) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_5897 | - | 1e-69 | 34.16% (442) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_4787 | - | 6e-68 | 34.25% (438) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0607 | mce2Da | 1e-79 | 37.04% (432) | hypothetical protein Mb0607 |
| M. gilvum PYR-GCK | Mflv_2104 | - | 1e-141 | 56.15% (447) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-155 | 62.04% (432) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 3e-80 | 38.56% (389) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 6e-65 | 33.63% (443) | MCE-family protein |
| M. marinum M | MMAR_2885 | mce3D | 1e-159 | 63.57% (431) | MCE-family protein Mce3D |
| M. avium 104 | MAV_2535 | - | 1e-143 | 56.63% (445) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3797 | - | 1e-148 | 59.44% (429) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2867 | mce3D | 1e-157 | 62.88% (431) | MCE-family protein Mce3D |
| M. vanbaalenii PYR-1 | Mvan_3979 | - | 1e-152 | 61.72% (431) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0607|M.bovis_AF2122/97 MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MMAR_2885|M.marinum_M -----MTTRLRRTR-----SVLATTLILVLVAGVIAAMRTAGDATRTLVV
MUL_2867|M.ulcerans_Agy99 -----MTTRLRRTR-----SVLATTLILVLVAGVIAAMRTAGDATRTLVV
Rv1969|M.tuberculosis_H37Rv -----MTTKLRRAR-----SVLAT--ALVLVAGVILAMRTADAAARTTVV
Mvan_3979|M.vanbaalenii_PYR-1 -----MSARLRRAR-----GGLAAVLVLTLAAGFLVAARAADHVERIWVT
MSMEG_0349|M.smegmatis_MC2_155 -------MRISKKQ-----LTLAAGLVVVMVAGVLVGFRMTGPAARTTIT
TH_3797|M.thermoresistible__bu ------VTQLNRHRN----IALAAVLVLTLVAGMIILVRMYAASDRVQYT
Mflv_2104|M.gilvum_PYR-GCK ---------MKNLR-----LWVGLVLVALLVVGVALLVRTTDKVNRVNVV
MAV_2535|M.avium_104 ---------------------MAIALTAVLLGGIVTVVRSAAGVGRTTVV
MAB_4150c|M.abscessus_ATCC_199 ----MTTSKTWLKR--------GAFAMLSVALVGGLLYWVWPSRGTYKIV
. .
Mb0607|M.bovis_AF2122/97 AYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPAT
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MMAR_2885|M.marinum_M AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRSKISFWFDRKYKVPAD
MUL_2867|M.ulcerans_Agy99 AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRSKISFWFDRKYKVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
Mvan_3979|M.vanbaalenii_PYR-1 AYFENSNGLFAGDDVRILGVPVGRVDSIRPEPTRARITFWVDRRYPVPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
TH_3797|M.thermoresistible__bu AYFENSNGVYPGDEVRILGVPVGQIDTVEPEPDRAKITFWVSEKYRVPAD
Mflv_2104|M.gilvum_PYR-GCK AYFENSNGIYEGDDVRILGVPVGRITSIEPEPERVKISFWYDDRYDVPAD
MAV_2535|M.avium_104 GYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWLNDKYKVPAD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* : .:: **.* * *: .* : : * :::: .: **
Mb0607|M.bovis_AF2122/97 ATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
MMAR_2885|M.marinum_M AKAAILSPQLVTGRAIQLTPPYSGGPTMASGAIISQQRTAVPVEWDDLRN
MUL_2867|M.ulcerans_Agy99 AKAAILSPQLVTGRAIQLTPPYSGGPTTASGAIISQQRTAVPVEWDDLRN
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
Mvan_3979|M.vanbaalenii_PYR-1 AKAVILSPQLVTGRAIQLTPAYTGGPVMPTGTVVGQERTAVPVEWDDVRV
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
TH_3797|M.thermoresistible__bu VRAVILSPQLVTARSIELTPAYTGGPTLQPGEVIPEDRTAVPVEWDDLRE
Mflv_2104|M.gilvum_PYR-GCK AAAAILSPALVTARAIQLTPVYTGGPVLGDNAVIPLQRTVVPVEWDQVRA
MAV_2535|M.avium_104 VKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQ
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: * **: * ::* * * .* : ::* **:.:*:.:
Mb0607|M.bovis_AF2122/97 SINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALT
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
MMAR_2885|M.marinum_M QLQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVS
MUL_2867|M.ulcerans_Agy99 QLQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
Mvan_3979|M.vanbaalenii_PYR-1 QLQRLTKLLRPTEPGGVSTLGAFINTTADNLRGQGANIRQTVVKLSQALA
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
TH_3797|M.thermoresistible__bu QLEKLTDALQPTEPGGVSTLGEFINTSAENLRGQGTDIRETVIKLSQAIS
Mflv_2104|M.gilvum_PYR-GCK QLERLSETLQPTEPGGVSPLGSVINTTAENLRGQGADIRETVIKLSQAFS
MAV_2535|M.avium_104 QLEKLTQVLQPTAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAIS
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQG-QSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: : * * .... .*: * : *:* :. :: .**::
Mb0607|M.bovis_AF2122/97 ALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
MMAR_2885|M.marinum_M TLSDHRNDIFSTVRNLSTLVSALHDSADLLEQLNHNLAAVSSLLATDPNK
MUL_2867|M.ulcerans_Agy99 TLSDHRNDIFSTVRNLSTLVSALHDSADLLEQLNHNLAAVSSLLATDPNK
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
Mvan_3979|M.vanbaalenii_PYR-1 ILGDHSDDIFTTFTNLSTLVSALHDSADLLEQLNQNMAAVTSLIADDPQK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
TH_3797|M.thermoresistible__bu ILGDHSDDLFTSIKNVSLLVSALHDSTDLLRQLNANLAQATGLLTNGPNE
Mflv_2104|M.gilvum_PYR-GCK ALGDRSTDIFSTIKNLAILVSALQDSTDLMRQLNQNLASVSGLLTDGPDE
MAV_2535|M.avium_104 ALGDHSNDLFSTVKNLSILVSALHDSSDLLQQLNQNLAEVTGLLANDPNE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
:.: *.. .: :* ** . : : :. ::* : :: . .
Mb0607|M.bovis_AF2122/97 LADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
MMAR_2885|M.marinum_M VGQAVEDINAVVADVQSFAAENREAVGTASDKLASISNALVAS--LDDIK
MUL_2867|M.ulcerans_Agy99 VGQAVKDINAVVADVQSFAAEYREAVGTASDKLASISNALVAS--LDDIK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVDS--LDDIK
Mvan_3979|M.vanbaalenii_PYR-1 VARTVQDLGGVIGDVKEFADDNREAIGTATDTLASVSTALVDS--LDDLK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALVQS--LDDIK
TH_3797|M.thermoresistible__bu VGQALADLDAAVRDVTDFVADNREAVGTTTNRLASITSALDES--VEEVK
Mflv_2104|M.gilvum_PYR-GCK VANAIRDLNAAVGDVQSFVAENRESLGTTSDKLAGVTTALTES--LEDIK
MAV_2535|M.avium_104 VANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVTDS--LGDVK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQ--SDDLE
:. : :. * * . .. : : : . ::
Mb0607|M.bovis_AF2122/97 TALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLICS-AIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
MMAR_2885|M.marinum_M QTLHIGPTVLQNFNNIFEPANGALTGALAANDFANPISFLCG-AIQSASR
MUL_2867|M.ulcerans_Agy99 QTLHIGPTVLQNLNNIFEPANGALTGALAANDFANPISFLCG-AIQSASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
Mvan_3979|M.vanbaalenii_PYR-1 QTLHIAPGTVANFHNIFEPANGSLTGALAVNNFANPISFICG-AIQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
TH_3797|M.thermoresistible__bu QALHIAPNTLANFYNIYQPAQAALTGALAVNNFADPVSFLCG-AIQAASR
Mflv_2104|M.gilvum_PYR-GCK QFLHVAPSTFQNYINIWQPAQGAVSSVPQINNFANPIQFLCG-AVQAASR
MAV_2535|M.avium_104 QLLHTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCG-AVEAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
** * * ::: * .:: . ::::.: ::*. ..::.::
Mb0607|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSEERL
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSEARL
MMAR_2885|M.marinum_M LGGEQAAKLCVQYLAPILKNRQYNFPPLGENLFVGAQARPNEVTYSEDWM
MUL_2867|M.ulcerans_Agy99 LGGEQAAKLCVQYLAPILKNRQYNFPPLGENLFVGAQARPNEVTYGEDWM
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWL
Mvan_3979|M.vanbaalenii_PYR-1 HGAEQSAKLCAQYLAPIVKNRQYNFPPIGENLLVGTQARPNEVTYSEDWL
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWL
TH_3797|M.thermoresistible__bu LGAEESSKLCVQYLAPIVKNRQYNFLPFGLNPFVGAAARPNEITYSEDWM
Mflv_2104|M.gilvum_PYR-GCK LGAEESAKLCVQYLAPIIKNRQYNFPPLGLNQLVGATTRPNELTYSEDWL
MAV_2535|M.avium_104 LGAKESAKLCVQYLAPIIKNRQVNFPPLGENLFVGAAARPNELTYSEDWL
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. :::* : :.*:: *: *: : : . :: :.
Mb0607|M.bovis_AF2122/97 RPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTANMLT
MLBr_02592|M.leprae_Br4923 QPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAALMT
MMAR_2885|M.marinum_M RPDYVPPQP---------------------------DMPPAERPADVTVE
MUL_2867|M.ulcerans_Agy99 RPDYVPPQP---------------------------DMPPAEPPADVTVE
Rv1969|M.tuberculosis_H37Rv RPDYVAPVA---------------------------DTPP-DPAAAVTVD
Mvan_3979|M.vanbaalenii_PYR-1 RPDFVPP-----------------------------AAPPADQPQAVAVD
MSMEG_0349|M.smegmatis_MC2_155 RPDYIPPAQPVTQ------------------DLDPEVLPAEAAPTDGSAD
TH_3797|M.thermoresistible__bu RPDYRPMSLPAP---------------------ADQSLPAEEPVVPAVRA
Mflv_2104|M.gilvum_PYR-GCK RPDYIPPGGPAPAPAAGVPTGDPAGLPPGQGP-LLLDAPPGAAEMPVPTN
MAV_2535|M.avium_104 RPDYVPP-HPDSPPTGDAPAPPAAGATPAEAPPPAADAPP--PAQAAPTN
MAB_4150c|M.abscessus_ATCC_199 EAKSQAPREDLVWVRPN--------------GAPPPPKPSPQDLSALMLG
..
Mb0607|M.bovis_AF2122/97 PESLAELLGGPDIAPPAAGNQLARTAECV---------------------
MLBr_02592|M.leprae_Br4923 PDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQASVPIPSP
MMAR_2885|M.marinum_M PDPAAGLRG--MMVPPGGG-------------------------------
MUL_2867|M.ulcerans_Agy99 PDPAAGLRG--MMVPPGGG-------------------------------
Rv1969|M.tuberculosis_H37Rv P--ATGLRG--MMMPPGGGS------------------------------
Mvan_3979|M.vanbaalenii_PYR-1 P--DAGLQG--MMVPAGGGVS-----------------------------
MSMEG_0349|M.smegmatis_MC2_155 P--SAGLPG--LMIPTEAGS------------------------------
TH_3797|M.thermoresistible__bu ADPSQGLPG--LMIPHGGGR------------------------------
Mflv_2104|M.gilvum_PYR-GCK P--TDGLHG--MMVPPGGGS------------------------------
MAV_2535|M.avium_104 P--AEGLRG--MMMPPGGGQ------------------------------
MAB_4150c|M.abscessus_ATCC_199 PDEVNAPPPPGTEVRPAEPGPVPPGFPVTADDAPPPAIPGAPR-------
.
Mb0607|M.bovis_AF2122/97 --------------------------------
MLBr_02592|M.leprae_Br4923 RPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
MMAR_2885|M.marinum_M --------------------------------
MUL_2867|M.ulcerans_Agy99 --------------------------------
Rv1969|M.tuberculosis_H37Rv --------------------------------
Mvan_3979|M.vanbaalenii_PYR-1 --------------------------------
MSMEG_0349|M.smegmatis_MC2_155 --------------------------------
TH_3797|M.thermoresistible__bu --------------------------------
Mflv_2104|M.gilvum_PYR-GCK --------------------------------
MAV_2535|M.avium_104 --------------------------------
MAB_4150c|M.abscessus_ATCC_199 --------------------------------