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MDSTVTASIRRMLGLLAATLLLGGCTGQHTTRTAASTTYTPHIKASSQDVLDGAINADEPGCSAAVGVEG KVIWSGVRGIADLASGAKITTDTVFDIASVSKQFTATAILLLVEAGKLTLDDPISQYVPELPDWAQTVTV EQLMHQTSGIPDYVALLAARGYQVSDRTIEAEARQALAAAPELQFKPGTRFDYSNSNYLLLGEIVHRASG QPLPEFLSAEIFQPLGLAMVVDPVGKVPNKAVSYEKGTGGNRSEYRVGNPAWEQIGDGGIQTTPSQLARW ADNYRTGSVGGLKLLEAQLAGAVETEPGGGDRYGAGIVSRADGTLDHAGAWAGFVTAFHISSDRRTSVAI SCNTDKPDPVAMADALGRLWM
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1922 | - | - | 100% (371) | PROBABLE CONSERVED LIPOPROTEIN |
| M. tuberculosis H37Rv | Rv0399c | lpqK | 1e-25 | 27.79% (385) | lipoprotein LpqK |
| M. tuberculosis H37Rv | Rv1730c | - | 3e-20 | 27.78% (360) | penicillin-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1957 | - | 0.0 | 100.00% (371) | lipoprotein |
| M. gilvum PYR-GCK | Mflv_0495 | - | 4e-18 | 31.55% (206) | beta-lactamase |
| M. leprae Br4923 | MLBr_00119 | lipE | 9e-12 | 27.62% (239) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0330 | - | 2e-30 | 31.32% (364) | Beta-lactamase |
| M. marinum M | MMAR_2827 | - | 1e-139 | 67.23% (357) | lipoprotein |
| M. avium 104 | MAV_3991 | - | 2e-18 | 31.63% (215) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_1586 | - | 4e-30 | 29.88% (338) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 2e-33 | 31.07% (309) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 8e-14 | 27.27% (220) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_3027 | - | 9e-29 | 29.46% (370) | Serine-type D-Ala-D-Ala carboxypeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0495|M.gilvum_PYR-GCK ------------------MTRSSTRLRRLGAAGAVVLALGACGDRPEPPG
MAV_3991|M.avium_104 -----------------------------------MLTLVAASSTGRVVH
Rv1922|M.tuberculosis_H37Rv -----------------------------MDST----------VTASIRR
Mb1957|M.bovis_AF2122/97 -----------------------------MDST----------VTASIRR
MMAR_2827|M.marinum_M MCDSLTRWTVRSDEVYGQHAGVCESLCGEGDSTTVIARDEAEAQTSSAPD
MSMEG_1586|M.smegmatis_MC2_155 -----------------------------------MMS-AWPLVPGFVRA
Mvan_3027|M.vanbaalenii_PYR-1 -------------------MADENGRRDSAHTLGAMITRALPIVFAMVLA
MAB_0330|M.abscessus_ATCC_1997 --------------------------------MPELSTRCFDESSLMRRI
TH_3520|M.thermoresistible__bu --------------------------------------------MRAVRT
MUL_1772|M.ulcerans_Agy99 -----------------------------------MGVARPRWRGPRAAW
MLBr_00119|M.leprae_Br4923 -----------------------------------------------MTS
Mflv_0495|M.gilvum_PYR-GCK TSAV-----------------------RPPATPTRVLPSPPPPVPEVT-P
MAV_3991|M.avium_104 TS--------------------------PSEAPPASMTPHASLVPESTSP
Rv1922|M.tuberculosis_H37Rv MLG---------------------LLAATLLLGGCTGQHTTRTAASTTYT
Mb1957|M.bovis_AF2122/97 MLG---------------------LLAATLLLGGCTGQHTTRTAASTTYT
MMAR_2827|M.marinum_M QVGSVRWKPVSSTHRCGWRSKWAPLLVIAVMLGACGGLPPAVTPPGTTDN
MSMEG_1586|M.smegmatis_MC2_155 ATG------------------------AVIAAITFVAASACATAPA---A
Mvan_3027|M.vanbaalenii_PYR-1 LTAC---------------------GESVDTTQTTGSRNPAVTAPATTMA
MAB_0330|M.abscessus_ATCC_1997 LAVV---------------------LTIALLVSACGKHSAIVVAEL---D
TH_3520|M.thermoresistible__bu LAA-------------------------LLLAVFAVSAGPSAAGQP----
MUL_1772|M.ulcerans_Agy99 FAG---------------------------ARKPSDGRRLTRRPPAANLN
MLBr_00119|M.leprae_Br4923 DGK-------------------------IRVPTDLDAVTAIGDEDHSDID
Mflv_0495|M.gilvum_PYR-GCK TGDFSAVARLVEDAIAARRLPGAVVQVGHAGKVVFRRAFGV--RKLESEP
MAV_3991|M.avium_104 AEDFTTISKLVNDAIAARGLPGAVVMVGHGGKVVFHQAYGS--RKLAGEP
Rv1922|M.tuberculosis_H37Rv PHIKASSQDVLDGAINAD-EPGCSAAVGVEGKVIWSGVRGI--ADLASG-
Mb1957|M.bovis_AF2122/97 PHIKASSQDVLDGAINAD-EPGCSAAVGVEGKVIWSGVRGI--ADLASG-
MMAR_2827|M.marinum_M SDLKTRSQRVLDGAVNPD-EPGCSAAVGVEGVVMWTGVLGI--ADLATN-
MSMEG_1586|M.smegmatis_MC2_155 PPIAAQLDDAVGKVMADLSIPGAVVGFWGP-DVTYVRAFGV--ADTATR-
Mvan_3027|M.vanbaalenii_PYR-1 AEVTDRLDDAVERVMTEAGIPGAIVGIWGP-GGDYVRAFGV--ADTKTR-
MAB_0330|M.abscessus_ATCC_1997 PQTTAKLDSAINEILTSAAVPGAIVGVWGP-KGQYVRTFGV--ANTATR-
TH_3520|M.thermoresistible__bu PDLAAALDRAIELRLDQMGVPGAIVSLSIPGKIEYTRAFGV--GDTATG-
MUL_1772|M.ulcerans_Agy99 PVNLDANQADIREVCDAGLLSGAVTVVWQHGEVLQVNEIGY--RDVEAG-
MLBr_00119|M.leprae_Br4923 SAAVERIWQATRHWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDP
. .. . * .
Mflv_0495|M.gilvum_PYR-GCK GLDGAPAPAEPMTEDTVFDIASLTKSLATATAVMQLHEQGRVRIDEPVQT
MAV_3991|M.avium_104 GLDGAPAPAEPMTEDTIFDLASLTKCLATAVAVMQLYEQGKVAFDDPVQK
Rv1922|M.tuberculosis_H37Rv ---------AKITTDTVFDIASVSKQFT-ATAILLLVEAGKLTLDDPISQ
Mb1957|M.bovis_AF2122/97 ---------AKITTDTVFDIASVSKQFT-ATAILLLVEAGKLTLDDPISQ
MMAR_2827|M.marinum_M ---------KKVTKDTVFDIGSVSKQFT-ATAVLLLINEGRLTLDDPLAH
MSMEG_1586|M.smegmatis_MC2_155 ---------APMQADMYTRIGSLTKTFT-ITALLTLIDQGKAGLDDPISM
Mvan_3027|M.vanbaalenii_PYR-1 ---------APMKTDFYSRIGSLTKTFT-VTAVLLLADQGRLGLDDPIAG
MAB_0330|M.abscessus_ATCC_1997 ---------APLRPDFYHRIGSVTKTFT-VTAVLQLVDEGKVELDDPIAK
TH_3520|M.thermoresistible__bu ---------TPMLVDNHHRIGSVTKTFI-GTAILQLADQGRIRLSDPISR
MUL_1772|M.ulcerans_Agy99 ---------LPMQRDTLFRIASMTKPVT-VAAAMSMVDEGKIALRDPITR
MLBr_00119|M.leprae_Br4923 ----HDAEKIPVTTDTPFCAYSAAKAIT-ATVVHMLVERGHFSLDDRVCE
: * * :* . .. : : *: : : :
Mflv_0495|M.gilvum_PYR-GCK YLPGFNPAGDPR------------RAAVTVRMLLTHTSGIAGDLSLDGPW
MAV_3991|M.avium_104 YLPAFNTTNDPQ------------RAKVTIRMLLTNTSGEGIDVSLRDPW
Rv1922|M.tuberculosis_H37Rv YVPELPDW----------------AQTVTVEQLMHQTSGIPDYVALLAAR
Mb1957|M.bovis_AF2122/97 YVPELPDW----------------AQTVTVEQLMHQTSGIPDYVALLAAR
MMAR_2827|M.marinum_M YVPDLPDW----------------SSAVTVAQLMHHTSGIPDYTGLLEAQ
MSMEG_1586|M.smegmatis_MC2_155 YVADVPS-----------------GDTITLRHLAQMQSGLVTYDGVPEFE
Mvan_3027|M.vanbaalenii_PYR-1 YVDGVPG-----------------GDAITLRQLARMQSGLPDYTANPEFV
MAB_0330|M.abscessus_ATCC_1997 YVDKVPN-----------------GNKITLRELARMQSGLFNYSMSLAFS
TH_3520|M.thermoresistible__bu YVEGVPS-----------------GDVITLDMLARMRSGLADYTETDEFV
MUL_1772|M.ulcerans_Agy99 WAPELRDIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDI
MLBr_00119|M.leprae_Br4923 YLPTYTSYG---------------KHRTTIRHVLTHSAGVPFPTGPRPDV
: : : :*
Mflv_0495|M.gilvum_PYR-GCK GLAGPDKADG-----------VRRALGAWVVSDPGEGFHYSDINFIILGA
MAV_3991|M.avium_104 GLAGPDKAEG-----------IHRALTTPLQSAPAGEFRYSDINYLLLGA
Rv1922|M.tuberculosis_H37Rv GYQVSDRTI-------EAEARQALAAAPELQFKPGTRFDYSNSNYLLLGE
Mb1957|M.bovis_AF2122/97 GYQVSDRTI-------EAEARQALAAAPELQFKPGTRFDYSNSNYLLLGE
MMAR_2827|M.marinum_M GYQMSDRTT-------QAQALAAIQGAPELEFKPGTRFEYSNSNYLLLAE
MSMEG_1586|M.smegmatis_MC2_155 AAFLADPQR-----TFTPQQLLGYALDKPLQFPPGTQYDYCNTNTVLLGL
Mvan_3027|M.vanbaalenii_PYR-1 PTVIADPGR-----AFAPTEMLEFAFSQPPMFAPGDGYHYSNTNTVLLGL
MAB_0330|M.abscessus_ATCC_1997 RDLEADPRR-----QYSTHELLDYAFAQPSNFVPGQGYEYSNTNAVLLGQ
TH_3520|M.thermoresistible__bu ERLYRESPSGPDAFAVTPRELVESAFARPLNFAPGSEFEYSNTNTVLLGM
MUL_1772|M.ulcerans_Agy99 SRAYMRLPFG-----HGSDAWLAELAALPLVHQPGERVTYS-HAIDLLGV
MLBr_00119|M.leprae_Br4923 TRADDHAYAQ-----------QKLSELRPFYRPGLVHIYHALTWGPLMRE
:. ::
Mflv_0495|M.gilvum_PYR-GCK LVEKITGEPEDSYVDRNVFAPLKMSETRYLPVTKVCGPHRVRGTAIAADP
MAV_3991|M.avium_104 LLEKITGEDEDDYVQHHVFGPLGMHDTRYLPPAKACGPHIIRGAAIAWAP
Rv1922|M.tuberculosis_H37Rv IVHRASGQPLPEFLSAEIFQPLGLAMVVDPVG---KVPNKAVSYEKGTGG
Mb1957|M.bovis_AF2122/97 IVHRASGQPLPEFLSAEIFQPLGLAMVVDPVG---KVPNKAVSYEKGTGG
MMAR_2827|M.marinum_M IVRLVSGKSLPDFLSIEIFRPLDLAMVVDPIS---ADPDEAVSYGEGDTG
MSMEG_1586|M.smegmatis_MC2_155 VVEKLSGQSLADYVRQHILVPLKLTHTSIPTSPAFPEPHPQGYTVLDGTP
Mvan_3027|M.vanbaalenii_PYR-1 VVEKVSGQSLGDYIRRHISAPLGMAETSFPTDATFPGPHATGYTVQPPDD
MAB_0330|M.abscessus_ATCC_1997 VVEKVSGQTLPAFVQEHITGPLGMRRTSFPETSAIADPHARGYTQLTPTG
TH_3520|M.thermoresistible__bu VVERVSGVPLARYLQDNIFGPVGLTQTSYPADGRLPAPYTHGYNQ-GPDG
MUL_1772|M.ulcerans_Agy99 IMSRIDDKPFYQVLDERILGPAGMTDTGFFVSTQAQRRAATMYRLDELDQ
MLBr_00119|M.leprae_Br4923 IIWTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVPLVALSHATGRPLP
:: . : .: * : .
Mflv_0495|M.gilvum_PYR-GCK HGQAVDNCPDGTWNIDLLERIAPTALDEDT---PGLNPDYGYPLRGTVHD
MAV_3991|M.avium_104 NGEPMTECPEWTWRTTLLPRIAPTARDEESRDDPSKNPDYYALLRGTVHD
Rv1922|M.tuberculosis_H37Rv NR---------------------------------------------SEY
Mb1957|M.bovis_AF2122/97 NR---------------------------------------------SEY
MMAR_2827|M.marinum_M NP---------------------------------------------PQF
MSMEG_1586|M.smegmatis_MC2_155 R-----------------------------------------------VT
Mvan_3027|M.vanbaalenii_PYR-1 RE---------------------------------------------MTA
MAB_0330|M.abscessus_ATCC_1997 SL---------------------------------------------VDS
TH_3520|M.thermoresistible__bu AI---------------------------------------------VDT
MUL_1772|M.ulcerans_Agy99 LR------------------------------------------HDVMGP
MLBr_00119|M.leprae_Br4923 PIIAAIFRKAIG----------------------------GTVHEVIPYT
Mflv_0495|M.gilvum_PYR-GCK PTARRMGGVAGSAGVFTTVHDMGRFAQALL-DRVAGRPSPFPLSQAGARM
MAV_3991|M.avium_104 PTARRMGGVAGNAGVFSTAHDVGVYAQALL-DRLAGRPSDFPLQQGTVEL
Rv1922|M.tuberculosis_H37Rv RVGNPAWEQIGDGGIQTTPSQLARWADNYR-TGSVGGLKLLEAQLAGAVE
Mb1957|M.bovis_AF2122/97 RVGNPAWEQIGDGGIQTTPSQLARWADNYR-TGSVGGLKLLEAQLAGAVE
MMAR_2827|M.marinum_M PVLHSGWEQVGDGAIQTTPSQLVLWADNYR-TGKVGGQKLLDEQLAGAVE
MSMEG_1586|M.smegmatis_MC2_155 TDWNPSWAWSN-GNMISTLDDMRVWAQKLS-SGELLSENLRDERFRTALP
Mvan_3027|M.vanbaalenii_PYR-1 TDWNLSWSWAA-GNMVSTLHDLRIWAPALV-TGTLLSRQMQQQRLQMVES
MAB_0330|M.abscessus_ATCC_1997 TDWNPSWASWA-GAMISTLDDLRIWVPALA-TGVLLKPDSQQQRLQTVAM
TH_3520|M.thermoresistible__bu TLWNPAWADAA-GKIVSNVHDMRTWARALG-SGALLRPDTHAERIHGG--
MUL_1772|M.ulcerans_Agy99 PHVRPPSFCNAGGGLWSTADDYLRFVRLLLGDGTIDGVRVLSPESVRLMR
MLBr_00119|M.leprae_Br4923 NTPPFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGAV
. :. : :.
Mflv_0495|M.gilvum_PYR-GCK MTTPQQP-----------------AP------GRDLRGFGWDIDTAHSGP
MAV_3991|M.avium_104 MTTPQQPGHDPRQLEAANRAARSGTPNYPAIKGQNLFGFGWDIDTGYSRP
Rv1922|M.tuberculosis_H37Rv TEPGGGD------------------------------RYGAGIVSRADGT
Mb1957|M.bovis_AF2122/97 TEPGGGD------------------------------RYGAGIVSRADGT
MMAR_2827|M.marinum_M TEPGSGD------------------------------RYGAGIFSRANGT
MSMEG_1586|M.smegmatis_MC2_155 MSENA--------------------------------KYGVGAFD-TNGW
Mvan_3027|M.vanbaalenii_PYR-1 SGQPAPE------------------------------EYGLGMFN-VAGW
MAB_0330|M.abscessus_ATCC_1997 PPVPDDI------------------------------RYGLGIFD-ARGW
TH_3520|M.thermoresistible__bu SSVVPGV------------------------------DYSFAIFN-AQGW
MUL_1772|M.ulcerans_Agy99 TDRLSDEHKRHNFLG---------------APFWVGRGFGLNLSVVTDPV
MLBr_00119|M.leprae_Br4923 AECRRLRPDFVVG------------------LMPARWGTGFILGTNKFGP
.
Mflv_0495|M.gilvum_PYR-GCK RGSVFP----VGSFGHTGFTGVSVWLDPESDTYVVILGNVIHQRGGPPIT
MAV_3991|M.avium_104 RGRVFP----IGSFGNTGFTGTTLWMDPGSDTYVILLSNSIHLRGSPPIS
Rv1922|M.tuberculosis_H37Rv LD---------HAGAWAGFVTAFHISSDRRTSVAISCNTDKPDP-----V
Mb1957|M.bovis_AF2122/97 LD---------HAGAWAGFVTAFHISSDRRTSVAISCNTDKPDP-----V
MMAR_2827|M.marinum_M LD---------HDGSWAGFVTDFRISSDRRTSVAVSCNMEGQDP-----E
MSMEG_1586|M.smegmatis_MC2_155 IG---------HSGITPGFETVVVGLPEAQSTLVVFVNTDVPH---EVGT
Mvan_3027|M.vanbaalenii_PYR-1 IG---------HNGSVPGYQTVSVYLPERQTALVILTNTDIAFRGAEPGT
MAB_0330|M.abscessus_ATCC_1997 IG---------HSGSIPGYQTLAIYSPAEQTTVVALLNTDVAKQPAQPST
TH_3520|M.thermoresistible__bu LG---------HNGDIPGYATVVVYLPERDATLVVFVNSDVPEP--HSAG
MUL_1772|M.ulcerans_Agy99 QSTPLFGPGGLGTFSWPGAYGTWWQADPGADLILLYLIQHCPDLSVNAAA
MLBr_00119|M.leprae_Br4923 FGRNAP-----AAFGHLGLVNIAIWADPQRSMAAGLISSGKPGQ--DPNA
. *
Mflv_0495|M.gilvum_PYR-GCK PLSGAVATEAARALHLYGS------------
MAV_3991|M.avium_104 NLRGDVATAAARALHLYGAAPP---------
Rv1922|M.tuberculosis_H37Rv AMADALGRLWM--------------------
Mb1957|M.bovis_AF2122/97 AMADALGRLWM--------------------
MMAR_2827|M.marinum_M SLADAIGRLWM--------------------
MSMEG_1586|M.smegmatis_MC2_155 AVATAVTGVVTPDNVYR--------------
Mvan_3027|M.vanbaalenii_PYR-1 LLARAVTTELTPDHVYTLS------------
MAB_0330|M.abscessus_ATCC_1997 LFGTAITKVISPDHVFLLENAIPQPR-----
TH_3520|M.thermoresistible__bu QIAYVVTEMVTPEHIYELGPQPPQMLDEPAA
MUL_1772|M.ulcerans_Agy99 AVAGNPGLAKLRTAQPRFVRRTYRALGL---
MLBr_00119|M.leprae_Br4923 GRYGALMNTITAEIPVH--------------