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MSAWPLVPGFVRAATGAVIAAITFVAASACATAPAAPPIAAQLDDAVGKVMADLSIPGAVVGFWGPDVTY VRAFGVADTATRAPMQADMYTRIGSLTKTFTITALLTLIDQGKAGLDDPISMYVADVPSGDTITLRHLAQ MQSGLVTYDGVPEFEAAFLADPQRTFTPQQLLGYALDKPLQFPPGTQYDYCNTNTVLLGLVVEKLSGQSL ADYVRQHILVPLKLTHTSIPTSPAFPEPHPQGYTVLDGTPRVTTDWNPSWAWSNGNMISTLDDMRVWAQK LSSGELLSENLRDERFRTALPMSENAKYGVGAFDTNGWIGHSGITPGFETVVVGLPEAQSTLVVFVNTDV PHEVGTAVATAVTGVVTPDNVYR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1586 | - | - | 100% (374) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3378 | - | 4e-76 | 43.01% (372) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_4455 | - | 3e-47 | 32.56% (387) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0405c | lpqK | 4e-37 | 32.66% (297) | lipoprotein LpqK |
| M. gilvum PYR-GCK | Mflv_0495 | - | 3e-14 | 29.39% (245) | beta-lactamase |
| M. tuberculosis H37Rv | Rv0399c | lpqK | 4e-37 | 32.66% (297) | lipoprotein LpqK |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0330 | - | 7e-96 | 48.86% (352) | Beta-lactamase |
| M. marinum M | MMAR_0696 | lpqK | 2e-43 | 32.07% (368) | lipoprotein, LpqK |
| M. avium 104 | MAV_3991 | - | 4e-15 | 28.11% (281) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 2e-79 | 44.69% (367) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 7e-10 | 25.61% (246) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_3027 | - | 1e-107 | 52.74% (383) | Serine-type D-Ala-D-Ala carboxypeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0495|M.gilvum_PYR-GCK -MTRSSTRLRRLGAAGAVVLALGACGDRPEPPGTSAVRPPATPTRVLPSP
MAV_3991|M.avium_104 ------------------MLTLVAASSTGRVVHTS---PSEAPPASMTPH
Mb0405c|M.bovis_AF2122/97 --------------MPVLRRLGCSVLALGLLAGCA-----------PPRT
Rv0399c|M.tuberculosis_H37Rv --------------MPVLRRLGCSVLALGLLAGCA-----------PPRT
MMAR_0696|M.marinum_M --------------MPILRRVAGVVFGVCLLAGCAALH--------PPQQ
MAB_0330|M.abscessus_ATCC_1997 MPELSTR---CFDESSLMRRILAVVLTIALLVSACGK----------HSA
Mvan_3027|M.vanbaalenii_PYR-1 MADENGRRDSAHTLGAMITRALPIVFAMVLALTACGESVDTTQTTGSRNP
MSMEG_1586|M.smegmatis_MC2_155 MMSAWPL------VPGFVRAATGAVIAAITFVAAS--------------A
TH_3520|M.thermoresistible__bu ---------------MRAVRTLAALLLAVFAVSAG--------------P
MUL_1772|M.ulcerans_Agy99 ----------MGVARPRWRGPRAAWFAGARKPSDG------------RRL
Mflv_0495|M.gilvum_PYR-GCK PPPVPEVT-PTGDFSAVARLVEDAIAARRLPGAVVQVGHAGKVVFRRAFG
MAV_3991|M.avium_104 ASLVPESTSPAEDFTTISKLVNDAIAARGLPGAVVMVGHGGKVVFHQAYG
Mb0405c|M.bovis_AF2122/97 GPASS-PTNNGAKADAVIRIVRDFMTQAHLKAVLVRVTVA--GKEVVTRA
Rv0399c|M.tuberculosis_H37Rv GPASS-PTNNGAKADAVIRIVRDFMTQAHLKAVLVRVTVA--GKEVVTRA
MMAR_0696|M.marinum_M SSAPTGPDGKGTKADAVMKVVRDFMGPAHLRSVIVRVSVD--GKEIVTDA
MAB_0330|M.abscessus_ATCC_1997 IVVA---ELDPQTTAKLDSAINEILTSAAVPGAIVGVWGP-KGQYVRTFG
Mvan_3027|M.vanbaalenii_PYR-1 AVTAPATTMAAEVTDRLDDAVERVMTEAGIPGAIVGIWGP-GGDYVRAFG
MSMEG_1586|M.smegmatis_MC2_155 CATAP---AAPPIAAQLDDAVGKVMADLSIPGAVVGFWGP-DVTYVRAFG
TH_3520|M.thermoresistible__bu SAAGQ----PPDLAAALDRAIELRLDQMGVPGAIVSLSIPGKIEYTRAFG
MUL_1772|M.ulcerans_Agy99 TRRPPAANLNPVNLDANQADIREVCDAGLLSGAVTVVWQHGEVLQVNEIG
: : ..:. . .
Mflv_0495|M.gilvum_PYR-GCK VRKLESEPGLDGAPAPAEPMTEDTVFDIASLTKSLATATAVMQLHEQGRV
MAV_3991|M.avium_104 SRKLAGEPGLDGAPAPAEPMTEDTIFDLASLTKCLATAVAVMQLYEQGKV
Mb0405c|M.bovis_AF2122/97 ----------VGDSMTGVPATTAMHFRNGAVAISYV-ATLLLKLVDEKKL
Rv0399c|M.tuberculosis_H37Rv ----------VGDSMTGVPATTAMHFRNGAVAISYV-ATLLLKLVDEKKL
MMAR_0696|M.marinum_M ----------VGDSMTGVPASTDMHFRNGAVAISYV-ATLLLKLVDEHKL
MAB_0330|M.abscessus_ATCC_1997 ----------VANTATRAPLRPDFYHRIGSVTKTFT-VTAVLQLVDEGKV
Mvan_3027|M.vanbaalenii_PYR-1 ----------VADTKTRAPMKTDFYSRIGSLTKTFT-VTAVLLLADQGRL
MSMEG_1586|M.smegmatis_MC2_155 ----------VADTATRAPMQADMYTRIGSLTKTFT-ITALLTLIDQGKA
TH_3520|M.thermoresistible__bu ----------VGDTATGTPMLVDNHHRIGSVTKTFI-GTAILQLADQGRI
MUL_1772|M.ulcerans_Agy99 ----------YRDVEAGLPMQRDTLFRIASMTKPVT-VAAAMSMVDEGKI
. * .::: . : : :: :
Mflv_0495|M.gilvum_PYR-GCK RIDEPVQTYLPGFNPA------------GDPRRAAVTVRMLLTHTSGIAG
MAV_3991|M.avium_104 AFDDPVQKYLPAFNTT------------NDPQRAKVTIRMLLTNTSGEGI
Mb0405c|M.bovis_AF2122/97 RLDDKLSRWLPDF-----------------PHADRVTLGQLAQMTSGYPD
Rv0399c|M.tuberculosis_H37Rv RLDDKLSRWLPDF-----------------PHADRVTLGQLAQMTSGYPD
MMAR_0696|M.marinum_M SLDDKLSKWLPDF-----------------PHADRVTLGQLAQMTSGYPD
MAB_0330|M.abscessus_ATCC_1997 ELDDPIAKYVDKV-----------------PNGNKITLRELARMQSGLFN
Mvan_3027|M.vanbaalenii_PYR-1 GLDDPIAGYVDGV-----------------PGGDAITLRQLARMQSGLPD
MSMEG_1586|M.smegmatis_MC2_155 GLDDPISMYVADV-----------------PSGDTITLRHLAQMQSGLVT
TH_3520|M.thermoresistible__bu RLSDPISRYVEGV-----------------PSGDVITLDMLARMRSGLAD
MUL_1772|M.ulcerans_Agy99 ALRDPITRWAPELRDIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAY
: : : : . * : : * **
Mflv_0495|M.gilvum_PYR-GCK DLSLDGPWG---LAGPDK---------ADGVRRALGAWVVSDPGEGFHYS
MAV_3991|M.avium_104 DVSLRDPWG---LAGPDK---------AEGIHRALTTPLQSAPAGEFRYS
Mb0405c|M.bovis_AF2122/97 YVLGNEAFDAELYANPFR-----QWTTQELLDQISSRPLLYDPGTNWNYA
Rv0399c|M.tuberculosis_H37Rv YVLGNEAFDAELYANPFR-----QWTTQELLDQISSRPLLYDPGTNWNYA
MMAR_0696|M.marinum_M YVLGNDEFGDALYADPFR-----QWTPQELLAQISSRPLLYEPGTNWNYA
MAB_0330|M.abscessus_ATCC_1997 YSMS-LAFSRDLEADPRR-----QYSTHELLDYAFAQPSNFVPGQGYEYS
Mvan_3027|M.vanbaalenii_PYR-1 YTAN-PEFVPTVIADPGR-----AFAPTEMLEFAFSQPPMFAPGDGYHYS
MSMEG_1586|M.smegmatis_MC2_155 YDGV-PEFEAAFLADPQR-----TFTPQQLLGYALDKPLQFPPGTQYDYC
TH_3520|M.thermoresistible__bu YTET-DEFVERLYRESPSGPDAFAVTPRELVESAFARPLNFAPGSEFEYS
MUL_1772|M.ulcerans_Agy99 SFSVSGDISRAYMRLPFG------HGSDAWLAELAALPLVHQPGERVTYS
. : *. *.
Mflv_0495|M.gilvum_PYR-GCK DINFIILGALVEKITGEPEDSYVDRNVFAPLKMSETRYLPVTKVCGPHRV
MAV_3991|M.avium_104 DINYLLLGALLEKITGEDEDDYVQHHVFGPLGMHDTRYLPPAKACGPHII
Mb0405c|M.bovis_AF2122/97 HTNYLLLGLALEKAAGQDMPTLLQRKVLSPLGLTATANSDTPAIPEPALH
Rv0399c|M.tuberculosis_H37Rv HTNYLLLGLALEKAAGQDMPTLLQRKVLSPLGLTATANSDTPAIPEPALH
MMAR_0696|M.marinum_M HTNYVLLGLALEKATGQDMATLLKQKVLAPLGLTATANSETPSIPDPALH
MAB_0330|M.abscessus_ATCC_1997 NTNAVLLGQVVEKVSGQTLPAFVQEHITGPLGMRRTSFPETSAIADPHAR
Mvan_3027|M.vanbaalenii_PYR-1 NTNTVLLGLVVEKVSGQSLGDYIRRHISAPLGMAETSFPTDATFPGPHAT
MSMEG_1586|M.smegmatis_MC2_155 NTNTVLLGLVVEKLSGQSLADYVRQHILVPLKLTHTSIPTSPAFPEPHPQ
TH_3520|M.thermoresistible__bu NTNTVLLGMVVERVSGVPLARYLQDNIFGPVGLTQTSYPADGRLPAPYTH
MUL_1772|M.ulcerans_Agy99 HA-IDLLGVIMSRIDDKPFYQVLDERILGPAGMTDTGFFVSTQAQRRAAT
. :** :.: . : .: * : *
Mflv_0495|M.gilvum_PYR-GCK RGTAIAADPHGQAVDNCPDGTWNIDLLERIAPTALDEDT---PGLNPDYG
MAV_3991|M.avium_104 RGAAIAWAPNGEPMTECPEWTWRTTLLPRIAPTARDEESRDDPSKNPDYY
Mb0405c|M.bovis_AF2122/97 AFTSERRAALK---------------------------------IPAGVP
Rv0399c|M.tuberculosis_H37Rv AFTSERRAALK---------------------------------IPAGVP
MMAR_0696|M.marinum_M AFSAERRAFLK---------------------------------IPADTP
MAB_0330|M.abscessus_ATCC_1997 GYTQL-----------------------------------------TPTG
Mvan_3027|M.vanbaalenii_PYR-1 GYTVQ-----------------------------------------PPDD
MSMEG_1586|M.smegmatis_MC2_155 GYTVL-----------------------------------------DGTP
TH_3520|M.thermoresistible__bu GYNQ------------------------------------------GPDG
MUL_1772|M.ulcerans_Agy99 MYRLDELDQLR-------------------------------------HD
Mflv_0495|M.gilvum_PYR-GCK YPLRGTVHDPTARRMGGVAGSAGVFTTVHDMGRFAQALLDRVAGRPSPFP
MAV_3991|M.avium_104 ALLRGTVHDPTARRMGGVAGNAGVFSTAHDVGVYAQALLDRLAGRPSDFP
Mb0405c|M.bovis_AF2122/97 FYEESTFWNPSWTITHGAIQTT----TIYDMEATAVGIGSGRLLSADSYK
Rv0399c|M.tuberculosis_H37Rv FYEESTFWNPSWTITHGAIQTT----TIYDMEATAVGIGSGRLLSADSYK
MMAR_0696|M.marinum_M FSEESTFWNPSWTITHGAIQTT----TIYDMEATAVGIGSGKLLSADSYQ
MAB_0330|M.abscessus_ATCC_1997 SLVDSTDWNPSWASWAGAMIS-----TLDDLRIWVPALATGVLLKPDSQQ
Mvan_3027|M.vanbaalenii_PYR-1 REMTATDWNLSWSWAAGNMVS-----TLHDLRIWAPALVTGTLLSRQMQQ
MSMEG_1586|M.smegmatis_MC2_155 R--VTTDWNPSWAWSNGNMIS-----TLDDMRVWAQKLSSGELLSENLRD
TH_3520|M.thermoresistible__bu AIVDTTLWNPAWADAAGKIVS-----NVHDMRTWARALGSGALLRPDTHA
MUL_1772|M.ulcerans_Agy99 VMGPPHVRPPSFCNAGGGLWSTADDYLRFVRLLLGDGTIDGVRVLSPESV
: * .
Mflv_0495|M.gilvum_PYR-GCK LSQAGARMMTTPQQP-----------------AP------GRDLRGFGWD
MAV_3991|M.avium_104 LQQGTVELMTTPQQPGHDPRQLEAANRAARSGTPNYPAIKGQNLFGFGWD
Mb0405c|M.bovis_AF2122/97 KMVSTELRGKTRAQPG----------------CPTCFEQNDGYSYGLGIV
Rv0399c|M.tuberculosis_H37Rv KMVSTELRGKTRAQPG----------------CPTCFEQNDGYSYGLGIV
MMAR_0696|M.marinum_M KMVSTALRGKTRAQPD----------------CPTCFEQSEGYTYGLGIV
MAB_0330|M.abscessus_ATCC_1997 QRLQTVAM----------------------------PPVPDDIRYGLGIF
Mvan_3027|M.vanbaalenii_PYR-1 QRLQMVES----------------------------SGQPAPEEYGLGMF
MSMEG_1586|M.smegmatis_MC2_155 ERFRTA------------------------------LPMSENAKYGVGAF
TH_3520|M.thermoresistible__bu ERIHGG------------------------------SSVVPGVDYSFAIF
MUL_1772|M.ulcerans_Agy99 RLMRTDRLSDEHKRHN-----------------FLGAPFWVGRGFGLNLS
..
Mflv_0495|M.gilvum_PYR-GCK IDTAHSGPRGSVFPVGSFGHTGFTGVSVWLDPESDTYVVILGN----VIH
MAV_3991|M.avium_104 IDTGYSRPRGRVFPIGSFGNTGFTGTTLWMDPGSDTYVILLSN----SIH
Mb0405c|M.bovis_AF2122/97 ISGHWLLQNP--------MFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDD
Rv0399c|M.tuberculosis_H37Rv ISGHWLLQNP--------MFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDD
MMAR_0696|M.marinum_M ISGHWLLQNP--------LFSGYAATEAYLPSQRVAIAVALTYTPEAFDD
MAB_0330|M.abscessus_ATCC_1997 DARGWIGHSG--------SIPGYQTLAIYSPAEQTTVVALLN-----TDV
Mvan_3027|M.vanbaalenii_PYR-1 NVAGWIGHNG--------SVPGYQTVSVYLPERQTALVILTN-----TDI
MSMEG_1586|M.smegmatis_MC2_155 DTNGWIGHSG--------ITPGFETVVVGLPEAQSTLVVFVN-----TDV
TH_3520|M.thermoresistible__bu NAQGWLGHNG--------DIPGYATVVVYLPERDATLVVFVN-----SDV
MUL_1772|M.ulcerans_Agy99 VVTDPVQSTPLFGPGGLGTFSWPGAYGTWWQADPGADLILLYLIQHCPDL
. :
Mflv_0495|M.gilvum_PYR-GCK QRGGPPITPLSGAVATEAARALHLYGS-------------
MAV_3991|M.avium_104 LRGSPPISNLRGDVATAAARALHLYGAAPP----------
Mb0405c|M.bovis_AF2122/97 QGNYRNQADILFRKIGAEVAPNDAPPMPPGR---------
Rv0399c|M.tuberculosis_H37Rv QGNYRNQADILFRKIGAEVAPNDAPPMPPGR---------
MMAR_0696|M.marinum_M EGNYPNQADILFRKIAAALVPDDAPPMPPGR---------
MAB_0330|M.abscessus_ATCC_1997 AKQPAQPSTLFGTAITKVISPDHVFLLENAIPQPR-----
Mvan_3027|M.vanbaalenii_PYR-1 AFRGAEPGTLLARAVTTELTPDHVYTLS------------
MSMEG_1586|M.smegmatis_MC2_155 PH---EVGTAVATAVTGVVTPDNVYR--------------
TH_3520|M.thermoresistible__bu PEP--HSAGQIAYVVTEMVTPEHIYELGPQPPQMLDEPAA
MUL_1772|M.ulcerans_Agy99 SVNAAAAVAGNPGLAKLRTAQPRFVRRTYRALGL------