For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VADENGRRDSAHTLGAMITRALPIVFAMVLALTACGESVDTTQTTGSRNPAVTAPATTMAAEVTDRLDDA VERVMTEAGIPGAIVGIWGPGGDYVRAFGVADTKTRAPMKTDFYSRIGSLTKTFTVTAVLLLADQGRLGL DDPIAGYVDGVPGGDAITLRQLARMQSGLPDYTANPEFVPTVIADPGRAFAPTEMLEFAFSQPPMFAPGD GYHYSNTNTVLLGLVVEKVSGQSLGDYIRRHISAPLGMAETSFPTDATFPGPHATGYTVQPPDDREMTAT DWNLSWSWAAGNMVSTLHDLRIWAPALVTGTLLSRQMQQQRLQMVESSGQPAPEEYGLGMFNVAGWIGHN GSVPGYQTVSVYLPERQTALVILTNTDIAFRGAEPGTLLARAVTTELTPDHVYTLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3027 | - | - | 100% (406) | Serine-type D-Ala-D-Ala carboxypeptidase |
| M. vanbaalenii PYR-1 | Mvan_3510 | - | 2e-38 | 30.03% (363) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_5895 | - | 8e-19 | 29.97% (287) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0405c | lpqK | 1e-35 | 28.74% (348) | lipoprotein LpqK |
| M. gilvum PYR-GCK | Mflv_0495 | - | 1e-29 | 30.74% (462) | beta-lactamase |
| M. tuberculosis H37Rv | Rv0399c | lpqK | 1e-35 | 28.74% (348) | lipoprotein LpqK |
| M. leprae Br4923 | MLBr_00119 | lipE | 8e-06 | 26.01% (173) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0330 | - | 1e-114 | 52.05% (390) | Beta-lactamase |
| M. marinum M | MMAR_0696 | lpqK | 8e-40 | 31.40% (363) | lipoprotein, LpqK |
| M. avium 104 | MAV_3991 | - | 6e-20 | 28.03% (289) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_1586 | - | 1e-107 | 52.74% (383) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 5e-85 | 44.67% (394) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_3735 | lipP | 9e-11 | 30.99% (171) | esterase/lipase LipP |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0495|M.gilvum_PYR-GCK MTRSSTRLRRLGAAGAVVLALGACGDRPEPPGTSAVRPPATPTRVLPSPP
MAV_3991|M.avium_104 -----------------MLTLVAASSTGRVVHTS---PSEAPPASMTPHA
Mb0405c|M.bovis_AF2122/97 -------------------------MPVLRRLGCSVLALGLLAGCA---P
Rv0399c|M.tuberculosis_H37Rv -------------------------MPVLRRLGCSVLALGLLAGCA---P
MMAR_0696|M.marinum_M -------------------------MPILRRVAGVVFGVCLLAGCAALHP
Mvan_3027|M.vanbaalenii_PYR-1 MADENGRRDSAHTLGAMITRALPIVFAMVLALTACGESVDTTQTTGSRNP
MSMEG_1586|M.smegmatis_MC2_155 ----------------MMS-AWPLVPGFVRAATG---AVIAAITFVAASA
MAB_0330|M.abscessus_ATCC_1997 -------------MPELSTRCFDESSLMRRILAVVLTIALLVSACGKHSA
TH_3520|M.thermoresistible__bu -------------------------MRAVRTLAA----LLLAVFAVSAGP
MUL_3735|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00119|M.leprae_Br4923 -----------------------------MTSDGKIRVPTDLDAVTAIGD
Mflv_0495|M.gilvum_PYR-GCK PPVPEVT-----PTGDFSAVARLVEDAIAARRLPGAVVQVGHAGKVVFRR
MAV_3991|M.avium_104 SLVPESTS----PAEDFTTISKLVNDAIAARGLPGAVVMVGHGGKVVFHQ
Mb0405c|M.bovis_AF2122/97 PRTGPASS-PTNNGAKADAVIRIVRDFMTQAHLKAVLVRVTVA--GKEVV
Rv0399c|M.tuberculosis_H37Rv PRTGPASS-PTNNGAKADAVIRIVRDFMTQAHLKAVLVRVTVA--GKEVV
MMAR_0696|M.marinum_M PQQSSAPTGPDGKGTKADAVMKVVRDFMGPAHLRSVIVRVSVD--GKEIV
Mvan_3027|M.vanbaalenii_PYR-1 AVTAPATT---MAAEVTDRLDDAVERVMTEAGIPGAIVGIWGP-GGDYVR
MSMEG_1586|M.smegmatis_MC2_155 CATAPA------APPIAAQLDDAVGKVMADLSIPGAVVGFWGP-DVTYVR
MAB_0330|M.abscessus_ATCC_1997 IVVAEL------DPQTTAKLDSAINEILTSAAVPGAIVGVWGP-KGQYVR
TH_3520|M.thermoresistible__bu SAAGQP-------PDLAAALDRAIELRLDQMGVPGAIVSLSIPGKIEYTR
MUL_3735|M.ulcerans_Agy99 ---------------------MEVGAAVAVWVDGDLVVNLWGG-------
MLBr_00119|M.leprae_Br4923 EDHSDIDS------AAVERIWQATRHWYQAGMHPAIQLCIRQHGRVVLNR
: .
Mflv_0495|M.gilvum_PYR-GCK AFGVRKLESEPGLDGAPAPAEPMTEDTVFDIASLTKSLATATAVMQLHEQ
MAV_3991|M.avium_104 AYGSRKLAGEPGLDGAPAPAEPMTEDTIFDLASLTKCLATAVAVMQLYEQ
Mb0405c|M.bovis_AF2122/97 TRA----------VGDSMTGVPATTAMHFRNGAVAISYV-ATLLLKLVDE
Rv0399c|M.tuberculosis_H37Rv TRA----------VGDSMTGVPATTAMHFRNGAVAISYV-ATLLLKLVDE
MMAR_0696|M.marinum_M TDA----------VGDSMTGVPASTDMHFRNGAVAISYV-ATLLLKLVDE
Mvan_3027|M.vanbaalenii_PYR-1 AFG----------VADTKTRAPMKTDFYSRIGSLTKTFT-VTAVLLLADQ
MSMEG_1586|M.smegmatis_MC2_155 AFG----------VADTATRAPMQADMYTRIGSLTKTFT-ITALLTLIDQ
MAB_0330|M.abscessus_ATCC_1997 TFG----------VANTATRAPLRPDFYHRIGSVTKTFT-VTAVLQLVDE
TH_3520|M.thermoresistible__bu AFG----------VGDTATGTPMLVDNHHRIGSVTKTFI-GTAILQLADQ
MUL_3735|M.ulcerans_Agy99 -------------SADAAGTRPWRQDTLTTVLSGSKALT-ATCVHQLADR
MLBr_00119|M.leprae_Br4923 AIGHG--WGNAPTDPHDAEKIPVTTDTPFCAYSAAKAIT-ATVVHMLVER
* : : . : * :.
Mflv_0495|M.gilvum_PYR-GCK GRVRIDEPVQTYLPGFNPAGDPRRAAVTVRMLLTHTSGIAGDLSLDGPWG
MAV_3991|M.avium_104 GKVAFDDPVQKYLPAFNTTNDPQRAKVTIRMLLTNTSGEGIDVSLRDPWG
Mb0405c|M.bovis_AF2122/97 KKLRLDDKLSRWLPDF-----PHADRVTLGQLAQMTSGYPDYVLGNEAFD
Rv0399c|M.tuberculosis_H37Rv KKLRLDDKLSRWLPDF-----PHADRVTLGQLAQMTSGYPDYVLGNEAFD
MMAR_0696|M.marinum_M HKLSLDDKLSKWLPDF-----PHADRVTLGQLAQMTSGYPDYVLGNDEFG
Mvan_3027|M.vanbaalenii_PYR-1 GRLGLDDPIAGYVDGV-----PGGDAITLRQLARMQSGLPDYTAN-PEFV
MSMEG_1586|M.smegmatis_MC2_155 GKAGLDDPISMYVADV-----PSGDTITLRHLAQMQSGLVTYDGV-PEFE
MAB_0330|M.abscessus_ATCC_1997 GKVELDDPIAKYVDKV-----PNGNKITLRELARMQSGLFNYSMS-LAFS
TH_3520|M.thermoresistible__bu GRIRLSDPISRYVEGV-----PSGDVITLDMLARMRSGLADYTET-DEFV
MUL_3735|M.ulcerans_Agy99 GELNLHAPVARYWPEFR---QAGKEAITVAMVLSHRSGVIGPNAR---MS
MLBr_00119|M.leprae_Br4923 GHFSLDDRVCEYLPTYTS---YGKHRTTIRHVLTHSAGVPFPTGPRPDVT
. : : : *: : :*
Mflv_0495|M.gilvum_PYR-GCK ---LAGPDK---------ADGVRRALGAWVVSDPGEGFHYSDINF-IILG
MAV_3991|M.avium_104 ---LAGPDK---------AEGIHRALTTPLQSAPAGEFRYSDINY-LLLG
Mb0405c|M.bovis_AF2122/97 AELYANPFR-----QWTTQELLDQISSRPLLYDPGTNWNYAHTNY-LLLG
Rv0399c|M.tuberculosis_H37Rv AELYANPFR-----QWTTQELLDQISSRPLLYDPGTNWNYAHTNY-LLLG
MMAR_0696|M.marinum_M DALYADPFR-----QWTPQELLAQISSRPLLYEPGTNWNYAHTNY-VLLG
Mvan_3027|M.vanbaalenii_PYR-1 PTVIADPGR-----AFAPTEMLEFAFSQPPMFAPGDGYHYSNTNT-VLLG
MSMEG_1586|M.smegmatis_MC2_155 AAFLADPQR-----TFTPQQLLGYALDKPLQFPPGTQYDYCNTNT-VLLG
MAB_0330|M.abscessus_ATCC_1997 RDLEADPRR-----QYSTHELLDYAFAQPSNFVPGQGYEYSNTNA-VLLG
TH_3520|M.thermoresistible__bu ERLYRESPSGPDAFAVTPRELVESAFARPLNFAPGSEFEYSNTNT-VLLG
MUL_3735|M.ulcerans_Agy99 WQQVTDWDF-----------VCEQLALAEPRWEPGSAQGYHMTTFGFILG
MLBr_00119|M.leprae_Br4923 RADDHAYAQ-------------QKLSELRPFYRPGLVHIYHALTWGPLMR
*. * . ::
Mflv_0495|M.gilvum_PYR-GCK ALVEKITGEPEDSYVDRNVFAPLKMSETR-------YLPVTKVCGPHRVR
MAV_3991|M.avium_104 ALLEKITGEDEDDYVQHHVFGPLGMHDTR-------YLPPAKACGPHIIR
Mb0405c|M.bovis_AF2122/97 LALEKAAGQDMPTLLQRKVLSPLGLTATA-------NSDTPAIPEPALHA
Rv0399c|M.tuberculosis_H37Rv LALEKAAGQDMPTLLQRKVLSPLGLTATA-------NSDTPAIPEPALHA
MMAR_0696|M.marinum_M LALEKATGQDMATLLKQKVLAPLGLTATA-------NSETPSIPDPALHA
Mvan_3027|M.vanbaalenii_PYR-1 LVVEKVSGQSLGDYIRRHISAPLGMAETS-------FPTDATFPGPHATG
MSMEG_1586|M.smegmatis_MC2_155 LVVEKLSGQSLADYVRQHILVPLKLTHTS-------IPTSPAFPEPHPQG
MAB_0330|M.abscessus_ATCC_1997 QVVEKVSGQTLPAFVQEHITGPLGMRRTS-------FPETSAIADPHARG
TH_3520|M.thermoresistible__bu MVVERVSGVPLARYLQDNIFGPVGLTQTS-------YPADGRLPAPYTHG
MUL_3735|M.ulcerans_Agy99 EVFRRITGRTVGQYLRTEIAEPIGADVHIGLSPFDQSRCAERVNKPHARD
MLBr_00119|M.leprae_Br4923 EIIWTATGKEIRDILAAEILDPLGFRWTN------FGVAEEDVPLVALSH
. :* : .: *:
Mflv_0495|M.gilvum_PYR-GCK GTAIAADPHGQAVDNCPDGTWNIDLLERIAPTALDEDT---PGLNPDYGY
MAV_3991|M.avium_104 GAAIAWAPNGEPMTECPEWTWRTTLLPRIAPTARDEESRDDPSKNPDYYA
Mb0405c|M.bovis_AF2122/97 FTSERRAALKIPAGVP---------------------------------F
Rv0399c|M.tuberculosis_H37Rv FTSERRAALKIPAGVP---------------------------------F
MMAR_0696|M.marinum_M FSAERRAFLKIPADTP---------------------------------F
Mvan_3027|M.vanbaalenii_PYR-1 YTVQPPDDREM---------------------------------------
MSMEG_1586|M.smegmatis_MC2_155 YTVLDGTPR-----------------------------------------
MAB_0330|M.abscessus_ATCC_1997 YTQLTPTGSLV---------------------------------------
TH_3520|M.thermoresistible__bu YNQ-GPDGAIV---------------------------------------
MUL_3735|M.ulcerans_Agy99 LLADVQAPSDPTSLDDHPKAGLSIAMG---------------------FA
MLBr_00119|M.leprae_Br4923 ATGRPLPPIIAAIFRKAIGG-----------------------------T
Mflv_0495|M.gilvum_PYR-GCK PLRGTVHDPTARRMGGVAGSAGVFTTVHDMGRFAQALLDRVAGRPSPFPL
MAV_3991|M.avium_104 LLRGTVHDPTARRMGGVAGNAGVFSTAHDVGVYAQALLDRLAGRPSDFPL
Mb0405c|M.bovis_AF2122/97 YEESTFWNPSWTITHGAIQTT----TIYDMEATAVGIGSGRLLSADSYKK
Rv0399c|M.tuberculosis_H37Rv YEESTFWNPSWTITHGAIQTT----TIYDMEATAVGIGSGRLLSADSYKK
MMAR_0696|M.marinum_M SEESTFWNPSWTITHGAIQTT----TIYDMEATAVGIGSGKLLSADSYQK
Mvan_3027|M.vanbaalenii_PYR-1 --TATDWNLSWSWAAGNMVS-----TLHDLRIWAPALVTGTLLSRQMQQQ
MSMEG_1586|M.smegmatis_MC2_155 --VTTDWNPSWAWSNGNMIS-----TLDDMRVWAQKLSSGELLSENLRDE
MAB_0330|M.abscessus_ATCC_1997 --DSTDWNPSWASWAGAMIS-----TLDDLRIWVPALATGVLLKPDSQQQ
TH_3520|M.thermoresistible__bu --DTTLWNPAWADAAGKIVS-----NVHDMRTWARALGSGALLRPDTHAE
MUL_3735|M.ulcerans_Agy99 PDDELGSNDLHLWRQLEFPGTNAQVSALGLATFYNALAQEKLLSREHMDL
MLBr_00119|M.leprae_Br4923 VHEVIPYTNTPPFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLR
. :
Mflv_0495|M.gilvum_PYR-GCK SQAGARMMTTPQQP-----------------AP------GRDLRGFGWDI
MAV_3991|M.avium_104 QQGTVELMTTPQQPGHDPRQLEAANRAARSGTPNYPAIKGQNLFGFGWDI
Mb0405c|M.bovis_AF2122/97 MVSTELRGKTRAQPG----------------CPTCFEQNDGYSYGLGIVI
Rv0399c|M.tuberculosis_H37Rv MVSTELRGKTRAQPG----------------CPTCFEQNDGYSYGLGIVI
MMAR_0696|M.marinum_M MVSTALRGKTRAQPD----------------CPTCFEQSEGYTYGLGIVI
Mvan_3027|M.vanbaalenii_PYR-1 RLQMVES----------------------------SGQPAPEEYGLGMFN
MSMEG_1586|M.smegmatis_MC2_155 RFRTALP----------------------------MSENA--KYGVGAFD
MAB_0330|M.abscessus_ATCC_1997 RLQTVAM----------------------------PPVPDDIRYGLGIFD
TH_3520|M.thermoresistible__bu RIHGG------------------------------SSVVPGVDYSFAIFN
MUL_3735|M.ulcerans_Agy99 VRVSQGGFDTDLVLG---------------------PRVADHGWGLGYML
MLBr_00119|M.leprae_Br4923 SETLLGAVAECRRLR-----------------PDFVVGLMPARWGTGFIL
. .
Mflv_0495|M.gilvum_PYR-GCK DTAHSGPRGSVFPVGSFGHTGFTGVSVWLDPESDTYVVILGN----VIHQ
MAV_3991|M.avium_104 DTGYSRPRGRVFPIGSFGNTGFTGTTLWMDPGSDTYVILLSN----SIHL
Mb0405c|M.bovis_AF2122/97 SGHWLLQNP--------MFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQ
Rv0399c|M.tuberculosis_H37Rv SGHWLLQNP--------MFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQ
MMAR_0696|M.marinum_M SGHWLLQNP--------LFSGYAATEAYLPSQRVAIAVALTYTPEAFDDE
Mvan_3027|M.vanbaalenii_PYR-1 VAGWIGHNG--------SVPGYQTVSVYLPERQTALVILTN-----TDIA
MSMEG_1586|M.smegmatis_MC2_155 TNGWIGHSG--------ITPGFETVVVGLPEAQSTLVVFVN-----TDVP
MAB_0330|M.abscessus_ATCC_1997 ARGWIGHSG--------SIPGYQTLAIYSPAEQTTVVALLN-----TDVA
TH_3520|M.thermoresistible__bu AQGWLGHNG--------DIPGYATVVVYLPERDATLVVFVN-----SDVP
MUL_3735|M.ulcerans_Agy99 NQRAVNGPNQ----KIFGHGGLGGSFGFVDLEHRIGYAYVMN-----RFD
MLBr_00119|M.leprae_Br4923 GTNKFGPFGRN-APAAFGHLGLVNIAIWADPQRSMAAGLISS------GK
*
Mflv_0495|M.gilvum_PYR-GCK RGGPPITPLSGAVATEAARALHLYGS-------------
MAV_3991|M.avium_104 RGSPPISNLRGDVATAAARALHLYGAAPP----------
Mb0405c|M.bovis_AF2122/97 GNYRNQADILFRKIGAEVAPNDAPPMPPGR---------
Rv0399c|M.tuberculosis_H37Rv GNYRNQADILFRKIGAEVAPNDAPPMPPGR---------
MMAR_0696|M.marinum_M GNYPNQADILFRKIAAALVPDDAPPMPPGR---------
Mvan_3027|M.vanbaalenii_PYR-1 FRGAEPGTLLARAVTTELTPDHVYTLS------------
MSMEG_1586|M.smegmatis_MC2_155 H---EVGTAVATAVTGVVTPDNVYR--------------
MAB_0330|M.abscessus_ATCC_1997 KQPAQPSTLFGTAITKVISPDHVFLLENAIPQPR-----
TH_3520|M.thermoresistible__bu EP--HSAGQIAYVVTEMVTPEHIYELGPQPPQMLDEPAA
MUL_3735|M.ulcerans_Agy99 ASKANADPRSVALSNEVYAALDVAAD-------------
MLBr_00119|M.leprae_Br4923 PGQDPNAGRYGALMNTITAEIPVH---------------