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CPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAY AIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYI PDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVV AGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTG GLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIV EHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPY EGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGS RSNFVRGPDGNIAWFCSQHGRLFRRQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1730c | - | - | 100% (517) | POSSIBLE PENICILLIN-BINDING PROTEIN |
| M. tuberculosis H37Rv | Rv0907 | - | 9e-25 | 28.08% (349) | hypothetical protein Rv0907 |
| M. tuberculosis H37Rv | Rv1922 | - | 5e-20 | 27.78% (360) | lipoprotein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1759c | - | 0.0 | 100.00% (517) | penicillin-binding protein |
| M. gilvum PYR-GCK | Mflv_1757 | - | 3e-23 | 29.24% (342) | beta-lactamase |
| M. leprae Br4923 | MLBr_00119 | lipE | 9e-10 | 27.57% (243) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2833 | - | 7e-25 | 27.17% (357) | beta-lactamase |
| M. marinum M | MMAR_4623 | - | 6e-25 | 29.55% (352) | penicillin binding protein |
| M. avium 104 | MAV_1030 | - | 4e-27 | 30.40% (352) | penicillin-binding protein 4 |
| M. smegmatis MC2 155 | MSMEG_5637 | - | 2e-25 | 28.86% (343) | penicillin-binding protein 4 |
| M. thermoresistible (build 8) | TH_0147 | - | 1e-137 | 55.41% (462) | POSSIBLE PENICILLIN-BINDING PROTEIN |
| M. ulcerans Agy99 | MUL_1772 | - | 2e-18 | 26.94% (297) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_4990 | - | 3e-26 | 30.12% (342) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1757|M.gilvum_PYR-GCK ---MK----SRVGAVALVMAVALLAGCAAESTEPAASSTPAPGPLSDVPP
Mvan_4990|M.vanbaalenii_PYR-1 ---MK----PRARVAALALTAALLAGCGTEGAEPAASSTPAPSPASDVPP
MSMEG_5637|M.smegmatis_MC2_155 MYSMRRSVFARAVGSALVVGLAVSGCAGGDDTADAQRSAQPSQTFADEPP
MMAR_4623|M.marinum_M MT-------KRAATTAVVMMFLALVGCA-----PKQSISNPPSTPSQLPP
MAV_1030|M.avium_104 MS-------KRAA--VLTAVLLGLTGCG-----SAQQPAGAPPRPSDVSP
Rv1730c|M.tuberculosis_H37Rv ----------MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEI
Mb1759c|M.bovis_AF2122/97 ----------MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEI
TH_0147|M.thermoresistible__bu --------------MRLS------RRSMLRATGGVVAGALLAGAVSGATT
MAB_2833|M.abscessus_ATCC_1997 ---------------------------MAEP-------------------
MUL_1772|M.ulcerans_Agy99 -------------------------MGVARPRWRGPRAAWFAGARKPSDG
MLBr_00119|M.leprae_Br4923 -----------------------------------MTSDGKIRVPTDLDA
Mflv_1757|M.gilvum_PYR-GCK PLVPAMPLPENAVANAVAKLDGLAEDLMSTSGVPGMAVAVVHQGKTVYAK
Mvan_4990|M.vanbaalenii_PYR-1 PLVPAMPLPENAVADAVAKLDGLAEDLMSKSGIPGMAVAVVHGGKAVYAK
MSMEG_5637|M.smegmatis_MC2_155 PLVPAMALPENAVENAVAKLDGIAEDLMRSSGIPGMAVAVVHGGKTVYAK
MMAR_4623|M.marinum_M NEVSGIDIPPGRIDEAVAKVDGLVAELMKSTGIPGMAVAIVHGGKTLYAK
MAV_1030|M.avium_104 NQVSALAIPAGRIDEAVAKVDGLVADLMRSSGIPGMAVAIVHGGKVLYAK
Rv1730c|M.tuberculosis_H37Rv ATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGG-QEYVK
Mb1759c|M.bovis_AF2122/97 ATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGG-QEYVK
TH_0147|M.thermoresistible__bu GCGRREDSDSGDR--LFAELDAKIQDLMDRHGVPGVAVGVWHDG-VEHLR
MAB_2833|M.abscessus_ATCC_1997 -------------DSTFDAALAPIRAAIDDRILAGAVTLVWQGGQLRHLG
MUL_1772|M.ulcerans_Agy99 RRLTRRPPAANLNPVNLDANQADIREVCDAGLLSGAVTVVWQHGEVLQVN
MLBr_00119|M.leprae_Br4923 VTAIGDEDHSDIDSAAVERIWQATRHWYQAGMHPAIQLCIRQHGRVVLNR
. .. : *
Mflv_1757|M.gilvum_PYR-GCK GFG----VKNNTQSDSPENRVDADTVFQLASLSKPLSATVVAALVGQDQV
Mvan_4990|M.vanbaalenii_PYR-1 GFG----VRNNTMSDEPHNEVDADTVFQLASLSKPLSATAVAALVGQNQV
MSMEG_5637|M.smegmatis_MC2_155 GFG----VRDVRNGDVESNRVDPDTVFQLASLSKPIAATVVAHQVGTGAI
MMAR_4623|M.marinum_M GFG----VRDVSKGDGQDNKVDTDTVFQLASMSKPIGATVVAHEVSTNVV
MAV_1030|M.avium_104 GFG----VKDVTSGQGRDNAVDTDTVFQLASVSKSVGATVVAHEVSDHVV
Rv1730c|M.tuberculosis_H37Rv GYG----VTNVDHPM----PVDGDTVFRIGSTTKTFTGTVMMRLVERGKV
Mb1759c|M.bovis_AF2122/97 GYG----VTNVDHPM----PVDGDTVFRIGSTTKTFTGTVMMRLVERGKV
TH_0147|M.thermoresistible__bu GFG----VTNVDDPE----PVTPDTLFRIGSTTKTFTGTTVMRLVEAGRI
MAB_2833|M.abscessus_ATCC_1997 ATG----YRDIDAGL----SMAENTIFRIASMTKPIISAATMNLVDDGTI
MUL_1772|M.ulcerans_Agy99 EIG----YRDVEAGL----PMQRDTLFRIASMTKPVTVAAAMSMVDEGKI
MLBr_00119|M.leprae_Br4923 AIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAKAITATVVHMLVERGHF
* : :* * * :*.. :. * .
Mflv_1757|M.gilvum_PYR-GCK GWDTPVVSRLPWFALSDPT------------TTQMVTVGDMFSHRSGLPD
Mvan_4990|M.vanbaalenii_PYR-1 SWDTPIVSRLPWFALSDPA------------VTQMVTVGDMFSHRSGLPD
MSMEG_5637|M.smegmatis_MC2_155 GWDTPVVEHLPWFALSDPV------------TTRMVTVGDLFAHRSGLPD
MMAR_4623|M.marinum_M SWDTPVVSKLPEFALSDPY------------VTDHATIADLYSHRSGLPD
MAV_1030|M.avium_104 GWDTPVVSTLPWFALGDPY------------VTGHVTVGDLYSHRSGLPD
Rv1730c|M.tuberculosis_H37Rv DLDSPVRRYIPDFAVADES------------ASATVTVRQLLNHTAGWDG
Mb1759c|M.bovis_AF2122/97 DLDSPVRRYIPDFAVADES------------ASATVTVRQLLNHTAGWDG
TH_0147|M.thermoresistible__bu DLDERVRTYLPDFTTADPT------------VAERVTVRQLLNHTPGWHG
MAB_2833|M.abscessus_ATCC_1997 RLSDPITTWLPEFSDMRVLKNPEGPLDDTFRAPRLITVEDLLTHRSGLTY
MUL_1772|M.ulcerans_Agy99 ALRDPITRWAPELRDIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAY
MLBr_00119|M.leprae_Br4923 SLDDRVCEYLPTYTSYGKH---------------RTTIRHVLTHSAGVPF
: * : .: * .*
Mflv_1757|M.gilvum_PYR-GCK HAGDQLEDLGYD-----------RRQVLDRLRQLPLAQFRTSYAYTNFGL
Mvan_4990|M.vanbaalenii_PYR-1 HAGDQLEDLGYD-----------RRQVLERLRQLPLDQFRTSYAYTNFGL
MSMEG_5637|M.smegmatis_MC2_155 HAGDQLEDLGYD-----------RRYILEHLRALPLDPFRNSYAYTNFGL
MMAR_4623|M.marinum_M HAGDALEDLGYD-----------TTQVLERLKYLPLDPFRISYAYTNFGV
MAV_1030|M.avium_104 HAGDKLEDLGYG-----------RRQICERLRLLPLRPFRNSYAYTNYGI
Rv1730c|M.tuberculosis_H37Rv RNGQDFGRGDD----------AVALYVKAMTRLPQLTPPGTAFAYNNSGL
Mb1759c|M.bovis_AF2122/97 RNGQDFGRGDD----------AVALYVKAMTRLPQLTPPGTAFAYNNSGL
TH_0147|M.thermoresistible__bu DYFVDTGSGED----------ALAKYVAAIATLPQQTPLGTTFAYNNAAI
MAB_2833|M.abscessus_ATCC_1997 DFISTGPIAKAYHPLHTAAFREPDEWLAAIAALPLVYPPGERFHYSHS-T
MUL_1772|M.ulcerans_Agy99 SFSVSGDISRAYMRLPFG--HGSDAWLAELAALPLVHQPGERVTYSHA-I
MLBr_00119|M.leprae_Br4923 PTGPRPDVTRAD---------DHAYAQQKLSELRPFYRPGLVHIYHALTW
*
Mflv_1757|M.gilvum_PYR-GCK TAGA-EAVATGAGKSWEDLAADTLLRPLGMGVTSYRFEDYASRRDRAVGH
Mvan_4990|M.vanbaalenii_PYR-1 TAGA-EAVATGAGKSWEDLAADTLLRPLGMGATSYRFSDYESRRDRAVGH
MSMEG_5637|M.smegmatis_MC2_155 TAAA-EAVAAAAGRSWEDLARDVLYRPLGMDSTSSRFADYEATQNRAVGH
MMAR_4623|M.marinum_M TAAA-DAVAAAAGKAWPDLSEEVLYRPLGMTSTSSRFADFLARPNHAVNH
MAV_1030|M.avium_104 TAAA-EAVAAAAGKTWEELSDEVLYRPLGMTSTSSRFADFLARPNRAVNH
Rv1730c|M.tuberculosis_H37Rv VVAG-RIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHS
Mb1759c|M.bovis_AF2122/97 VVAG-RIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHS
TH_0147|M.thermoresistible__bu ALAG-RIIEAVTGTGYERVVRTELLEPLGLQHTGFSVDNLEGPPVAEPHT
MAB_2833|M.abscessus_ATCC_1997 DVLG-LLIARAAGLPLNTLLRQRILDPLGMNDTDFFVPEHKAARLARLYG
MUL_1772|M.ulcerans_Agy99 DLLG-VIMSRIDDKPFYQVLDERILGPAGMTDTGFFVSTQAQRRAATMYR
MLBr_00119|M.leprae_Br4923 GPLMREIIWTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVPLVALSHA
: . : * : *
Mflv_1757|M.gilvum_PYR-GCK IRIDDGYQPRYVRD--------AQAQSPAGGASSSVNDMTRWMAMVLAEG
Mvan_4990|M.vanbaalenii_PYR-1 IRIDGGYQPRFVRD--------AQAQSPAGGASSSVNDMTRWMAMVLADG
MSMEG_5637|M.smegmatis_MC2_155 IRVDGRYEPQYVRN--------ADAQTPAGGVSASVDDMTRWLAMVLGDG
MMAR_4623|M.marinum_M IKVGDRWEARFQRD--------PDAQTPAGGVSSSLNDMAHWLTMVLANG
MAV_1030|M.avium_104 IKIGDSWQARFQRN--------PDAQSPAGGVSSSVRDMARWLMMLLDNG
Rv1730c|M.tuberculosis_H37Rv VVDGKPIAVTDFWT-------FPRSCNPTGGLMSTARDQLRYAQFHLGDG
Mb1759c|M.bovis_AF2122/97 VVDGKPIAVTDFWT-------FPRSCNPTGGLMSTARDQLRYAQFHLGDG
TH_0147|M.thermoresistible__bu MADGAPRFDRSAWY-------MPRCLNPTGGLISTARDQLRYARFHLGDG
MAB_2833|M.abscessus_ATCC_1997 LGDDDTIVAADSGYLTAMPTSAPALCRGGGALASTAHDYLTFARALLGGG
MUL_1772|M.ulcerans_Agy99 LDELDQLRHDVMGPPHVRP---PSFCNAGGGLWSTADDYLRFVRLLLGDG
MLBr_00119|M.leprae_Br4923 TGRPLPPIIAAIFR---------KAIGGTVHEVIPYTNTPPFLTTIVPSS
. : : : .
Mflv_1757|M.gilvum_PYR-GCK R-HDGNALIDPQALLPAISPQVTSAPPTEPAMRPGFYGYGFNVGTTSAAR
Mvan_4990|M.vanbaalenii_PYR-1 R-HDGNQLIDPTALLPAITPQVTSSRGSEPAMRSGFYGYGFNVGTTSAAR
MSMEG_5637|M.smegmatis_MC2_155 V-FEGERIVEESTLLPAITPQVVSDRASQPAMRSGFYGYGFNVGTTSAAR
MMAR_4623|M.marinum_M E-YNGQQIVSPEALLPAITPQVISSAARSPKARAGFYGHGFTVSVSSAGR
MAV_1030|M.avium_104 T-HDGQHIASPEALLPALSPQVVSAPATTPKARTGFYGYGFNTSVDASGR
Rv1730c|M.tuberculosis_H37Rv RAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWM----LRPSAEN
Mb1759c|M.bovis_AF2122/97 RAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWM----LRPSAEN
TH_0147|M.thermoresistible__bu GGLPDLGLLSEESLTAMRSDPGPGGTLAVEIDGMGVTWH----LRPSAEG
MAB_2833|M.abscessus_ATCC_1997 Q-ADGVRILSPESTQALRTNR----------------------LTPAQRR
MUL_1772|M.ulcerans_Agy99 T-IDGVRVLSPESVRLMRTDR----------------------LSDEHKR
MLBr_00119|M.leprae_Br4923 NTVSTANELSRFAEIWLRGGELDG--------------------IRVLRS
. :
Mflv_1757|M.gilvum_PYR-GCK TQLSHSGAFELGAATNVLFLPSADVAIIALTNATPTGVPETLTAQFADLV
Mvan_4990|M.vanbaalenii_PYR-1 TQLSHSGAFELGAATNVLFLPSADVAIVALTNATPTGIPETLTAQFADLV
MSMEG_5637|M.smegmatis_MC2_155 TQLSHSGAFELGAATNFVILPSADVGIVALTNGTPAGIPETLTAEFADLV
MMAR_4623|M.marinum_M TQYGHSGAFGLGAATNFVVLPSEDIAIVALTNAAPYGIPEALTAQFMDLV
MAV_1030|M.avium_104 TEYSHSGAFDLGAATNFVVLPSEDLAIIALTNAAPYGIPETLTAEFMDLV
Rv1730c|M.tuberculosis_H37Rv VTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTN-SDGGFHMINDLFASDWA
Mb1759c|M.bovis_AF2122/97 VTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTN-SDGGFHMINDLFASDWA
TH_0147|M.thermoresistible__bu VHIVQHGGAWSGQHSGFYLVPDRDFAMTVLTN-SDGGAMLVADLMYTDWA
MAB_2833|M.abscessus_ATCC_1997 LPSFGIP-YWTGR--GFGLG------LSVVMD-PNE-AALFGPGGTGTFG
MUL_1772|M.ulcerans_Agy99 HNFLGAP-FWVGR--GFGLN------LSVVTD-PVQSTPLFGPGGLGTFS
MLBr_00119|M.leprae_Br4923 ETLLGAVAECRRLRPDFVVG---------LMPARWGTGFILGTNKFGPFG
.. . :
Mflv_1757|M.gilvum_PYR-GCK QFGEIRQDWAALYGKAFADMDKPVGSLVGQQRHVNAQTHGPLDSYTGVYG
Mvan_4990|M.vanbaalenii_PYR-1 QFGEIRQDWYALYAKAFEDMDKPVGSLVGQQRPANAQAHGPLAAYTGVYR
MSMEG_5637|M.smegmatis_MC2_155 QFGEVRQDWRKLYADAFASMDGPEGELVGKKPPAVPAPARPLPDYVGVYR
MMAR_4623|M.marinum_M QYGEVREDWTNLYRQQMSPINTPEGSLVGKQPPVNPEPARPPSDYVGVYA
MAV_1030|M.avium_104 QYGQIREDWAALYRKAIGWLNNPLGSLVGKQPPSAPAPARPLRDYTGVYA
Rv1730c|M.tuberculosis_H37Rv LQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRAR
Mb1759c|M.bovis_AF2122/97 LQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRAR
TH_0147|M.thermoresistible__bu LDHFAGLHNLPAPVRDLSPAELADYEGRYHAYETGVDGSVDATDTVLTAD
MAB_2833|M.abscessus_ATCC_1997 WPGAFGTWWHADPKADAILMFLPQWRMPELDPKAALARTST---IRLQLL
MUL_1772|M.ulcerans_Agy99 WPGAYGTWWQADPGADLILLYLIQH-CPDLSVNAAAAVAGNPGLAKLRTA
MLBr_00119|M.leprae_Br4923 RN-------APAAFGHLGLVNIAIWADPQRSMAAGLISSGKPGQDPNAGR
Mflv_1757|M.gilvum_PYR-GCK NDYWGPATVTERDGRLQLALGPRG-VFELDAWDGNVFVFPVSSENAPPGT
Mvan_4990|M.vanbaalenii_PYR-1 NDYWGPATVTERDGHLELALGPRG-VFKLQPWDGNVFTFPVSSENAPPGT
MSMEG_5637|M.smegmatis_MC2_155 NDYWGPATVTEQDGALQLALGPKF-KARLTHWDGDVFTFRFVSENAPPGT
MMAR_4623|M.marinum_M NDYWGPATVTERDGQLQLSMGPKNQTFDLTHWDGDTFTFALSTENALPGS
MAV_1030|M.avium_104 NDYWGPAVITEHDGALQLTMGPQHRTATLTHWDGDTFTFPLTGENAPPGT
Rv1730c|M.tuberculosis_H37Rv DGQLAGSMSTDDANP--DGQNSAN---LGLAFYRPDYGLDLGPDNKPTGS
Mb1759c|M.bovis_AF2122/97 DGQLAGSMSTDDANP--DGQNSAN---LGLAFYRPDYGLDLGPDNKPTGS
TH_0147|M.thermoresistible__bu RGRLRYQMLSDDGAPVTDPPPGTP---AYLAFYRDDYVLQLDRDGEPLPS
MAB_2833|M.abscessus_ATCC_1997 HVQFGQAVYAAL--------------------------------------
MUL_1772|M.ulcerans_Agy99 QPRFVRRTYRALGL------------------------------------
MLBr_00119|M.leprae_Br4923 YGALMNTITAEIPVH-----------------------------------
Mflv_1757|M.gilvum_PYR-GCK VSAATFDG---GALTLEYFDQEGNGVFVR--
Mvan_4990|M.vanbaalenii_PYR-1 VSAATFDA---GSLTLEYFDDEGKGVFTR--
MSMEG_5637|M.smegmatis_MC2_155 ISKATFAG---DKLTLEYFDEDGTGTFTR--
MMAR_4623|M.marinum_M ISKATFAG---DTLNLEYFDSNKLGTFTR--
MAV_1030|M.avium_104 VSTATFTGSPAARLNLEYYDTDQLGTFTR--
Rv1730c|M.tuberculosis_H37Rv RSNFVRGP----DGNIAWFCSQHGRLFRRQ-
Mb1759c|M.bovis_AF2122/97 RSNFVRGP----DGNIAWFCSQHGRLFRRQ-
TH_0147|M.thermoresistible__bu RADFVRDD----TGQVRWLR-IGGRLHRKTA
MAB_2833|M.abscessus_ATCC_1997 -------------------------------
MUL_1772|M.ulcerans_Agy99 -------------------------------
MLBr_00119|M.leprae_Br4923 -------------------------------