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M. vanbaalenii PYR-1 Mvan_4613 (-)

annotation: putative adenylate/guanylate cyclase
coordinates: 4954795 - 4955580
length: 261

MALLVLAAVVVGLAVALAVQSRRLRTARQEADELRRRLDTRQMLVTGSTKAVKTVWQTANILRRDGFGAA
VRSSIEELADWAEVERPDLARLAPNGRVAIMFSDIEESTALNERIGDRAFVRLLGRHDKPVRRHVDAHDG
YVVKSQGDGFMVAFARPEQAVRCGLAIQHSLDKRPNGIRVRIGIHVGKSVLRGDDLFGRNVAMAARVAAE
ADGGEVLVSSAVRDALTDADDIVVDGERDAHLKGFSGSHTLYSVRSASASR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_4613--100% (261)putative adenylate/guanylate cyclase
M. vanbaalenii PYR-1Mvan_3321-1e-1334.31% (137) putative adenylate/guanylate cyclase
M. vanbaalenii PYR-1Mvan_5928-2e-1332.87% (143) regulatory protein, LuxR

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1151c-2e-4966.21% (145) hypothetical protein Mb1151c
M. gilvum PYR-GCKMflv_2091-1e-11680.54% (257) putative adenylate/guanylate cyclase
M. tuberculosis H37RvRv1120c-4e-5066.90% (145) hypothetical protein Rv1120c
M. leprae Br4923MLBr_01399-6e-1430.54% (167) hypothetical protein MLBr_01399
M. abscessus ATCC 19977MAB_4771-7e-1227.33% (161) putative adenylate cyclase
M. marinum MMMAR_4340-5e-9367.18% (262) hypothetical protein MMAR_4340
M. avium 104MAV_1250-3e-8764.48% (259) adenylate and guanylate cyclase catalytic domain-containing
M. smegmatis MC2 155MSMEG_4477-3e-1634.19% (155) hydrolase, alpha/beta hydrolase fold family protein
M. thermoresistible (build 8)TH_1244-1e-9366.17% (269) CONSERVED HYPOTHETICAL PROTEIN
M. ulcerans Agy99MUL_0150-1e-8669.43% (229) hypothetical protein MUL_0150

CLUSTAL 2.0.9 multiple sequence alignment


Mvan_4613|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2091|M.gilvum_PYR-GCK          -------------------------------------------------M
TH_1244|M.thermoresistible__bu      -------------------VAARPLPLAVAAAPGSPIPRRVGQDGAVTQI
Mb1151c|M.bovis_AF2122/97           --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4340|M.marinum_M               ---------------------------------------------MTDAL
MUL_0150|M.ulcerans_Agy99           --------------------------------------------------
MAV_1250|M.avium_104                ---------------------------------------------MGDVL
MSMEG_4477|M.smegmatis_MC2_155      MAETSYASCGDLSLAYQLFGDGPIPLVFVGPFVGHVELFWTVPEFKSFFD
MLBr_01399|M.leprae_Br4923          --------------MPPSAKSTYPGQVEGAPHDGTPSAPQEPDEDTVTVP
MAB_4771|M.abscessus_ATCC_1997      ---------MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVER
                                                                                      

Mvan_4613|M.vanbaalenii_PYR-1       -MALLVLAAVVVGLAVALAVQSRRLRTARQEADELRRRLDTR--------
Mflv_2091|M.gilvum_PYR-GCK          LILVCVLAVLAAGLGIALAVQTRRLTSARQEAEELRHRLDTR--------
TH_1244|M.thermoresistible__bu      AIVVVALAGLALAEAVALAVLWGRLRRERRAADELRRRLDTR--------
Mb1151c|M.bovis_AF2122/97           --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4340|M.marinum_M               HIAVYVLAGVAALEAAALIALWRLLARARQENDELRQRADSR--------
MUL_0150|M.ulcerans_Agy99           ----------------------------------MRQRADSR--------
MAV_1250|M.avium_104                HVTVYILAGLAAVEAGALAVLWRRLVRSRAELDELRQRTDAR--------
MSMEG_4477|M.smegmatis_MC2_155      QLASFCRVAIFDKAGTGLSDPVPKVRTLDDRAAEIEAVMDAVGFDDAVVL
MLBr_01399|M.leprae_Br4923          APALIRRSSVSMPNAAQWLHTTNRSPRLVAMVRRARRLLPGDPDFG----
MAB_4771|M.abscessus_ATCC_1997      ARTLWVALGFAAADSDDEVAFTDADVSAIRTFAALGSATAANQQSQ----
                                                                                      

Mvan_4613|M.vanbaalenii_PYR-1       -------------------------------------------------Q
Mflv_2091|M.gilvum_PYR-GCK          -------------------------------------------------Q
TH_1244|M.thermoresistible__bu      -------------------------------------------------T
Mb1151c|M.bovis_AF2122/97           --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4340|M.marinum_M               -------------------------------------------------N
MUL_0150|M.ulcerans_Agy99           -------------------------------------------------N
MAV_1250|M.avium_104                -------------------------------------------------N
MSMEG_4477|M.smegmatis_MC2_155      AMSEGGPASILFAANRPGRVRTLVAYGSFATMAGCRWEDLDGDPVDIRAR
MLBr_01399|M.leprae_Br4923          -------------------------------------------------D
MAB_4771|M.abscessus_ATCC_1997      ------------------------------------------------IA
                                                                                      

Mvan_4613|M.vanbaalenii_PYR-1       MLVTGSTKAVKTVWQTANILRRD--------GFGAAVRSSIEEL------
Mflv_2091|M.gilvum_PYR-GCK          LLVSGGTKAVKTVWQTANILRKD--------GFGAAVRSSIEEL------
TH_1244|M.thermoresistible__bu      TLMAGGREAVRTVWQTANILRTD--------GLGAAARSSIEDL------
Mb1151c|M.bovis_AF2122/97           -MLSGGREAVKTVWQTANLVRKE--------GFGAAVRSSIEDP------
Rv1120c|M.tuberculosis_H37Rv        -MLSGGREAVKTVWQTANLVRKE--------GFGAAVRSSIEDP------
MMAR_4340|M.marinum_M               WLLTGGREAVKTVWQTANLMRKE--------GFGAAVRSSIEDL------
MUL_0150|M.ulcerans_Agy99           WLLTGGREAVKTVWQTANLMRKE--------GFGAAVRSSIEDL------
MAV_1250|M.avium_104                WLLAGGREAVKTVWNTANLVRKE--------GFGAAVRSSIEEL------
MSMEG_4477|M.smegmatis_MC2_155      SVAEMGDEYAPTVEQVIHFQEQARA-VRGQWGSGAAVRCAMPSMGSMRQL
MLBr_01399|M.leprae_Br4923          PLSTAGEGGPRAAARAADRLLGD---------RGAASREVSLSV------
MAB_4771|M.abscessus_ATCC_1997      AARTLGQAMARLAEWQADLLTREVGGRLAAEGDDASAESSANAATQTIAT
                                         .      .    .               .*: .            

Mvan_4613|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2091|M.gilvum_PYR-GCK          --------------------------------------------------
TH_1244|M.thermoresistible__bu      --------------------------------------------------
Mb1151c|M.bovis_AF2122/97           --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4340|M.marinum_M               --------------------------------------------------
MUL_0150|M.ulcerans_Agy99           --------------------------------------------------
MAV_1250|M.avium_104                --------------------------------------------------
MSMEG_4477|M.smegmatis_MC2_155      GMFERLCASPGMARATFEAAFRIDVRPILPTIAAPTLVIHARDDPAVPVQ
MLBr_01399|M.leprae_Br4923          --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997      LTALQN--------------------------------------------
                                                                                      

Mvan_4613|M.vanbaalenii_PYR-1       -----------ADWAEVERPDLARLAPNGR--------------------
Mflv_2091|M.gilvum_PYR-GCK          -----------ADWAEVERPDLARLSLNGR--------------------
TH_1244|M.thermoresistible__bu      -----------ADWAEVERPDLARLAANGK--------------------
Mb1151c|M.bovis_AF2122/97           -----------ADWAEVERPDLARVTPDAR--------------------
Rv1120c|M.tuberculosis_H37Rv        -----------ADWAEVERPDLARVTPDGR--------------------
MMAR_4340|M.marinum_M               -----------ADWAEVERPDLARVTPDGR--------------------
MUL_0150|M.ulcerans_Agy99           -----------ADWAEVERPDLARVTPDGR--------------------
MAV_1250|M.avium_104                -----------ADWAEVERPDLARVTPDGR--------------------
MSMEG_4477|M.smegmatis_MC2_155      CSRYLADHISGARWLEVDGVDHAPWFTEADRVLTEIEEFVTGNHAAPHNS
MLBr_01399|M.leprae_Br4923          -----------LQVWQALTEAIARRPVNPE--------------------
MAB_4771|M.abscessus_ATCC_1997      -----------YAWQRHLAAALHRANETGSTTR-----------------
                                                   .                                  

Mvan_4613|M.vanbaalenii_PYR-1       ----VAIMFSDIEESTALNERIGDRAFVRLLGRHDKPVRRHVDAHDGYVV
Mflv_2091|M.gilvum_PYR-GCK          ----LTIMFSDIEESTALNERIGDRAFVRLIGRHDKSVRKFVDKHEGHVV
TH_1244|M.thermoresistible__bu      ----VVILFSDIEGSTALNNRIGDRAWVRLIDRHSRLVRRFVKKHDGYVI
Mb1151c|M.bovis_AF2122/97           ----VVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMV
Rv1120c|M.tuberculosis_H37Rv        ----VVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMV
MMAR_4340|M.marinum_M               ----VVILFSDIEESTALNERIGDRAWVKLIGAHDKMVHEFVHRHGGHVV
MUL_0150|M.ulcerans_Agy99           ----VVILFSDIEESTVLNERIGNRAWVKLIGAHDKMVHEFVHRHGGHVV
MAV_1250|M.avium_104                ----VVILFTDIEESTALNERIGDRAWVKLISSHDKLVSDLVRRQSGHVV
MSMEG_4477|M.smegmatis_MC2_155      HRALRTVLFTDIVASTQHAASNGDERWRAVLQRFGEVTEELSGRFGGVVV
MLBr_01399|M.leprae_Br4923          ----VTLVFTDLVGFSGWSLQAGDEATLALLRQVARAVESPLLDAGGHIV
MAB_4771|M.abscessus_ATCC_1997      ---QLLVGFADMVGYTRLSRHLDPDELASLLETFETALTEAITTHGGWVI
                                          : *:*:   :      .      ::               * ::

Mvan_4613|M.vanbaalenii_PYR-1       KSQGDGFMVAFARPEQAVRCGLAIQHSLD-----KRPNGIRVRIGIHVGK
Mflv_2091|M.gilvum_PYR-GCK          KSQGDGFMVAFAKPEQAVRCGLDIQHSLA-----RRPNDIRVRMGVHTGK
TH_1244|M.thermoresistible__bu      KSQGDGFMVAFARPEQAVRCSVELQRALR-----KRPDRIRVRIGIHLGR
Mb1151c|M.bovis_AF2122/97           TSQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWG-
Rv1120c|M.tuberculosis_H37Rv        TSQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWG-
MMAR_4340|M.marinum_M               KSQGDGFMIAFARAEQAVRCGLDIQRALSREAKRKPRNGIRVRIGIHMGR
MUL_0150|M.ulcerans_Agy99           KSQGDGFMIAFARAEQAVRCGLDIQHALSREAKRKPRNGIRVRIGIHMGR
MAV_1250|M.avium_104                KSQGDGFMVAFARPEQAVRCGIELQRALRRNANRKRHEEIRVRIGIHMGR
MSMEG_4477|M.smegmatis_MC2_155      KSTGDGHLSTFEGPTHAIRYAEALRSDAET-------LGIQIRAAIHTGE
MLBr_01399|M.leprae_Br4923          KRMGDGIMAVFRDPSVAVQAVLAATEAMKS--VEVGGYTPRIRVGIHTGR
MAB_4771|M.abscessus_ATCC_1997      KNVGDEVMFAAASAAAGARIAVAMNTAITEA-AQTIPDMPQIRVGLAYGQ
                                    .  **  : .   .  . :                     ::* .   * 

Mvan_4613|M.vanbaalenii_PYR-1       SVLRGDDLFGRNVAMAARVAAEADGGEVLVSSAVRDALTDADDIV-----
Mflv_2091|M.gilvum_PYR-GCK          SVLRGDDVFGRNVAMAARVAAAADGGEILVSSAVHRALADCEDLA-----
TH_1244|M.thermoresistible__bu      SVRRGDDLFGRNVALAARVAGAAEGGEVLVSQAVRDALNSAGDAGSDEVA
Mb1151c|M.bovis_AF2122/97           -ARCG------TVTICSAATSQ----------------------------
Rv1120c|M.tuberculosis_H37Rv        -ARCG------TVTICSAATSQ----------------------------
MMAR_4340|M.marinum_M               SVRRGDDLFGRNVAMAARVAGQAGGGQILVSEPVRDAVRDCGDIR-----
MUL_0150|M.ulcerans_Agy99           SVRRGDDLFGRNVAMAARVAGQAVGGQILVSEPVRDAVRDCGDIR-----
MAV_1250|M.avium_104                SVRRGDDLFGRNVAMAARVAAQAAGGEILVSQPVRDALSRSDGIR-----
MSMEG_4477|M.smegmatis_MC2_155      CELLGDDIGGIAVHIAARILGQARAGEILVSRTVRDLVVGSGTSF-----
MLBr_01399|M.leprae_Br4923          PQRLAADWLGVDVNIAARVMERATKGGIMISGPTLDLIPQSDLKELGIIT
MAB_4771|M.abscessus_ATCC_1997      VLSRFGDLYGTVVNIAARLTGVARPGTILLDDGAAAALGDDGEFS-----
                                                * :.:                                 

Mvan_4613|M.vanbaalenii_PYR-1       ---VDGERDAHLKGFSGSHTLYSVRSASASR-------------------
Mflv_2091|M.gilvum_PYR-GCK          ---FDEQRDVELKGFSGSHTLYPVRSASASR-------------------
TH_1244|M.thermoresistible__bu      GFDVDDGREVSLKGFPGRHRLFAVRGQAGFRPRPRPE-------------
Mb1151c|M.bovis_AF2122/97           --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4340|M.marinum_M               ---VDDGRDVELKGFSGSYRLFGVETAPECEPD-----------------
MUL_0150|M.ulcerans_Agy99           ---VDDGRDVELKGFSGSYRLFGVETAPECEPD-----------------
MAV_1250|M.avium_104                ---FDDGREVELKGFSGTYRLFAVLASPDPG-------------------
MSMEG_4477|M.smegmatis_MC2_155      ----ADRGNVELRGVPGTWQLLAVGDGAGGGSPAGSVEALLAAEPTPAAR
MLBr_01399|M.leprae_Br4923          RRVRKPMFTSKFTGIPPDMVIYRIKARRELTASDETAQTNSLT-------
MAB_4771|M.abscessus_ATCC_1997      ---LRHLRGVRVKGFS-RLGSHVLRARKR---------------------
                                                                                      

Mvan_4613|M.vanbaalenii_PYR-1       ----------------------------------
Mflv_2091|M.gilvum_PYR-GCK          ----------------------------------
TH_1244|M.thermoresistible__bu      ----------------------------------
Mb1151c|M.bovis_AF2122/97           ----------------------------------
Rv1120c|M.tuberculosis_H37Rv        ----------------------------------
MMAR_4340|M.marinum_M               ----------------------------------
MUL_0150|M.ulcerans_Agy99           ----------------------------------
MAV_1250|M.avium_104                ----------------------------------
MSMEG_4477|M.smegmatis_MC2_155      TATRRADRAVAAVAKRTPWALRGVARLTMSATRR
MLBr_01399|M.leprae_Br4923          ----------------------------------
MAB_4771|M.abscessus_ATCC_1997      ----------------------------------