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LILVCVLAVLAAGLGIALAVQTRRLTSARQEAEELRHRLDTRQLLVSGGTKAVKTVWQTANILRKDGFGA AVRSSIEELADWAEVERPDLARLSLNGRLTIMFSDIEESTALNERIGDRAFVRLIGRHDKSVRKFVDKHE GHVVKSQGDGFMVAFAKPEQAVRCGLDIQHSLARRPNDIRVRMGVHTGKSVLRGDDVFGRNVAMAARVAA AADGGEILVSSAVHRALADCEDLAFDEQRDVELKGFSGSHTLYPVRSASASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2091 | - | - | 100% (263) | putative adenylate/guanylate cyclase |
| M. gilvum PYR-GCK | Mflv_1780 | - | 9e-34 | 44.81% (183) | putative adenylate/guanylate cyclase |
| M. gilvum PYR-GCK | Mflv_3535 | - | 5e-16 | 35.04% (137) | putative adenylate/guanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1151c | - | 1e-50 | 65.10% (149) | hypothetical protein Mb1151c |
| M. tuberculosis H37Rv | Rv1120c | - | 2e-51 | 65.77% (149) | hypothetical protein Rv1120c |
| M. leprae Br4923 | MLBr_01399 | - | 1e-13 | 28.49% (179) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_4771 | - | 9e-12 | 27.27% (165) | putative adenylate cyclase |
| M. marinum M | MMAR_4340 | - | 1e-92 | 66.41% (262) | hypothetical protein MMAR_4340 |
| M. avium 104 | MAV_1250 | - | 1e-88 | 64.48% (259) | adenylate and guanylate cyclase catalytic domain-containing |
| M. smegmatis MC2 155 | MSMEG_4477 | - | 2e-15 | 33.97% (156) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_1244 | - | 3e-90 | 62.83% (269) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0150 | - | 8e-87 | 68.56% (229) | hypothetical protein MUL_0150 |
| M. vanbaalenii PYR-1 | Mvan_4613 | - | 1e-116 | 80.54% (257) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2091|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu -------------------VAARPLPLAVAAAPGSPIPRRVGQDGAVTQI
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4340|M.marinum_M ---------------------------------------------MTDAL
MUL_0150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1250|M.avium_104 ---------------------------------------------MGDVL
MSMEG_4477|M.smegmatis_MC2_155 MAETSYASCGDLSLAYQLFGDGPIPLVFVGPFVGHVELFWTVPEFKSFFD
MLBr_01399|M.leprae_Br4923 --------------MPPSAKSTYPGQVEGAPHDGTPSAPQEPDEDTVTVP
MAB_4771|M.abscessus_ATCC_1997 ---------MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVER
Mflv_2091|M.gilvum_PYR-GCK LILVCVLAVLAAGLGIALAVQTRRLTSARQEAEELRHRLDTR--------
Mvan_4613|M.vanbaalenii_PYR-1 -MALLVLAAVVVGLAVALAVQSRRLRTARQEADELRRRLDTR--------
TH_1244|M.thermoresistible__bu AIVVVALAGLALAEAVALAVLWGRLRRERRAADELRRRLDTR--------
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4340|M.marinum_M HIAVYVLAGVAALEAAALIALWRLLARARQENDELRQRADSR--------
MUL_0150|M.ulcerans_Agy99 ----------------------------------MRQRADSR--------
MAV_1250|M.avium_104 HVTVYILAGLAAVEAGALAVLWRRLVRSRAELDELRQRTDAR--------
MSMEG_4477|M.smegmatis_MC2_155 QLASFCRVAIFDKAGTGLSDPVPKVRTLDDRAAEIEAVMDAVGFDDAVVL
MLBr_01399|M.leprae_Br4923 APALIRRSSVSMPNAAQWLHTTNRSPRLVAMVRRARRLLPGDPDFG----
MAB_4771|M.abscessus_ATCC_1997 ARTLWVALGFAAADSDDEVAFTDADVSAIRTFAALGSATAANQQSQ----
Mflv_2091|M.gilvum_PYR-GCK -------------------------------------------------Q
Mvan_4613|M.vanbaalenii_PYR-1 -------------------------------------------------Q
TH_1244|M.thermoresistible__bu -------------------------------------------------T
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4340|M.marinum_M -------------------------------------------------N
MUL_0150|M.ulcerans_Agy99 -------------------------------------------------N
MAV_1250|M.avium_104 -------------------------------------------------N
MSMEG_4477|M.smegmatis_MC2_155 AMSEGGPASILFAANRPGRVRTLVAYGSFATMAGCRWEDLDGDPVDIRAR
MLBr_01399|M.leprae_Br4923 -------------------------------------------------D
MAB_4771|M.abscessus_ATCC_1997 ------------------------------------------------IA
Mflv_2091|M.gilvum_PYR-GCK LLVSGGTKAVKTVWQTANILRKD--------GFGAAVRSSIEEL------
Mvan_4613|M.vanbaalenii_PYR-1 MLVTGSTKAVKTVWQTANILRRD--------GFGAAVRSSIEEL------
TH_1244|M.thermoresistible__bu TLMAGGREAVRTVWQTANILRTD--------GLGAAARSSIEDL------
Mb1151c|M.bovis_AF2122/97 -MLSGGREAVKTVWQTANLVRKE--------GFGAAVRSSIEDP------
Rv1120c|M.tuberculosis_H37Rv -MLSGGREAVKTVWQTANLVRKE--------GFGAAVRSSIEDP------
MMAR_4340|M.marinum_M WLLTGGREAVKTVWQTANLMRKE--------GFGAAVRSSIEDL------
MUL_0150|M.ulcerans_Agy99 WLLTGGREAVKTVWQTANLMRKE--------GFGAAVRSSIEDL------
MAV_1250|M.avium_104 WLLAGGREAVKTVWNTANLVRKE--------GFGAAVRSSIEEL------
MSMEG_4477|M.smegmatis_MC2_155 SVAEMGDEYAPTVEQVIHFQEQARA-VRGQWGSGAAVRCAMPSMGSMRQL
MLBr_01399|M.leprae_Br4923 PLSTAGEGGPRAAARAADRLLGD---------RGAASREVSLSV------
MAB_4771|M.abscessus_ATCC_1997 AARTLGQAMARLAEWQADLLTREVGGRLAAEGDDASAESSANAATQTIAT
. . . .*: .
Mflv_2091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu --------------------------------------------------
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4340|M.marinum_M --------------------------------------------------
MUL_0150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1250|M.avium_104 --------------------------------------------------
MSMEG_4477|M.smegmatis_MC2_155 GMFERLCASPGMARATFEAAFRIDVRPILPTIAAPTLVIHARDDPAVPVQ
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 LTALQN--------------------------------------------
Mflv_2091|M.gilvum_PYR-GCK -----------ADWAEVERPDLARLSLNGR--------------------
Mvan_4613|M.vanbaalenii_PYR-1 -----------ADWAEVERPDLARLAPNGR--------------------
TH_1244|M.thermoresistible__bu -----------ADWAEVERPDLARLAANGK--------------------
Mb1151c|M.bovis_AF2122/97 -----------ADWAEVERPDLARVTPDAR--------------------
Rv1120c|M.tuberculosis_H37Rv -----------ADWAEVERPDLARVTPDGR--------------------
MMAR_4340|M.marinum_M -----------ADWAEVERPDLARVTPDGR--------------------
MUL_0150|M.ulcerans_Agy99 -----------ADWAEVERPDLARVTPDGR--------------------
MAV_1250|M.avium_104 -----------ADWAEVERPDLARVTPDGR--------------------
MSMEG_4477|M.smegmatis_MC2_155 CSRYLADHISGARWLEVDGVDHAPWFTEADRVLTEIEEFVTGNHAAPHNS
MLBr_01399|M.leprae_Br4923 -----------LQVWQALTEAIARRPVNPE--------------------
MAB_4771|M.abscessus_ATCC_1997 -----------YAWQRHLAAALHRANETGSTTR-----------------
.
Mflv_2091|M.gilvum_PYR-GCK ----LTIMFSDIEESTALNERIGDRAFVRLIGRHDKSVRKFVDKHEGHVV
Mvan_4613|M.vanbaalenii_PYR-1 ----VAIMFSDIEESTALNERIGDRAFVRLLGRHDKPVRRHVDAHDGYVV
TH_1244|M.thermoresistible__bu ----VVILFSDIEGSTALNNRIGDRAWVRLIDRHSRLVRRFVKKHDGYVI
Mb1151c|M.bovis_AF2122/97 ----VVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMV
Rv1120c|M.tuberculosis_H37Rv ----VVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMV
MMAR_4340|M.marinum_M ----VVILFSDIEESTALNERIGDRAWVKLIGAHDKMVHEFVHRHGGHVV
MUL_0150|M.ulcerans_Agy99 ----VVILFSDIEESTVLNERIGNRAWVKLIGAHDKMVHEFVHRHGGHVV
MAV_1250|M.avium_104 ----VVILFTDIEESTALNERIGDRAWVKLISSHDKLVSDLVRRQSGHVV
MSMEG_4477|M.smegmatis_MC2_155 HRALRTVLFTDIVASTQHAASNGDERWRAVLQRFGEVTEELSGRFGGVVV
MLBr_01399|M.leprae_Br4923 ----VTLVFTDLVGFSGWSLQAGDEATLALLRQVARAVESPLLDAGGHIV
MAB_4771|M.abscessus_ATCC_1997 ---QLLVGFADMVGYTRLSRHLDPDELASLLETFETALTEAITTHGGWVI
: *:*: : . :: * ::
Mflv_2091|M.gilvum_PYR-GCK KSQGDGFMVAFAKPEQAVRCGLDIQHSLA-----RRPNDIRVRMGVHTGK
Mvan_4613|M.vanbaalenii_PYR-1 KSQGDGFMVAFARPEQAVRCGLAIQHSLD-----KRPNGIRVRIGIHVGK
TH_1244|M.thermoresistible__bu KSQGDGFMVAFARPEQAVRCSVELQRALR-----KRPDRIRVRIGIHLGR
Mb1151c|M.bovis_AF2122/97 TSQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWG-
Rv1120c|M.tuberculosis_H37Rv TSQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWG-
MMAR_4340|M.marinum_M KSQGDGFMIAFARAEQAVRCGLDIQRALSREAKRKPRNGIRVRIGIHMGR
MUL_0150|M.ulcerans_Agy99 KSQGDGFMIAFARAEQAVRCGLDIQHALSREAKRKPRNGIRVRIGIHMGR
MAV_1250|M.avium_104 KSQGDGFMVAFARPEQAVRCGIELQRALRRNANRKRHEEIRVRIGIHMGR
MSMEG_4477|M.smegmatis_MC2_155 KSTGDGHLSTFEGPTHAIRYAEALRSDAET-------LGIQIRAAIHTGE
MLBr_01399|M.leprae_Br4923 KRMGDGIMAVFRDPSVAVQAVLAATEAMKS--VEVGGYTPRIRVGIHTGR
MAB_4771|M.abscessus_ATCC_1997 KNVGDEVMFAAASAAAGARIAVAMNTAITEA-AQTIPDMPQIRVGLAYGQ
. ** : . . . : ::* . *
Mflv_2091|M.gilvum_PYR-GCK SVLRGDDVFGRNVAMAARVAAAADGGEILVSSAVHRALADCEDLA-----
Mvan_4613|M.vanbaalenii_PYR-1 SVLRGDDLFGRNVAMAARVAAEADGGEVLVSSAVRDALTDADDIV-----
TH_1244|M.thermoresistible__bu SVRRGDDLFGRNVALAARVAGAAEGGEVLVSQAVRDALNSAGDAGSDEVA
Mb1151c|M.bovis_AF2122/97 -ARCG------TVTICSAATSQ----------------------------
Rv1120c|M.tuberculosis_H37Rv -ARCG------TVTICSAATSQ----------------------------
MMAR_4340|M.marinum_M SVRRGDDLFGRNVAMAARVAGQAGGGQILVSEPVRDAVRDCGDIR-----
MUL_0150|M.ulcerans_Agy99 SVRRGDDLFGRNVAMAARVAGQAVGGQILVSEPVRDAVRDCGDIR-----
MAV_1250|M.avium_104 SVRRGDDLFGRNVAMAARVAAQAAGGEILVSQPVRDALSRSDGIR-----
MSMEG_4477|M.smegmatis_MC2_155 CELLGDDIGGIAVHIAARILGQARAGEILVSRTVRDLVVGSGTSF-----
MLBr_01399|M.leprae_Br4923 PQRLAADWLGVDVNIAARVMERATKGGIMISGPTLDLIPQSDLKELGIIT
MAB_4771|M.abscessus_ATCC_1997 VLSRFGDLYGTVVNIAARLTGVARPGTILLDDGAAAALGDDGEFS-----
* :.:
Mflv_2091|M.gilvum_PYR-GCK ---FDEQRDVELKGFSGSHTLYPVRSASASR-------------------
Mvan_4613|M.vanbaalenii_PYR-1 ---VDGERDAHLKGFSGSHTLYSVRSASASR-------------------
TH_1244|M.thermoresistible__bu GFDVDDGREVSLKGFPGRHRLFAVRGQAGFRPRPRPE-------------
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4340|M.marinum_M ---VDDGRDVELKGFSGSYRLFGVETAPECEPD-----------------
MUL_0150|M.ulcerans_Agy99 ---VDDGRDVELKGFSGSYRLFGVETAPECEPD-----------------
MAV_1250|M.avium_104 ---FDDGREVELKGFSGTYRLFAVLASPDPG-------------------
MSMEG_4477|M.smegmatis_MC2_155 ----ADRGNVELRGVPGTWQLLAVGDGAGGGSPAGSVEALLAAEPTPAAR
MLBr_01399|M.leprae_Br4923 RRVRKPMFTSKFTGIPPDMVIYRIKARRELTASDETAQTNSLT-------
MAB_4771|M.abscessus_ATCC_1997 ---LRHLRGVRVKGFS-RLGSHVLRARKR---------------------
Mflv_2091|M.gilvum_PYR-GCK ----------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 ----------------------------------
TH_1244|M.thermoresistible__bu ----------------------------------
Mb1151c|M.bovis_AF2122/97 ----------------------------------
Rv1120c|M.tuberculosis_H37Rv ----------------------------------
MMAR_4340|M.marinum_M ----------------------------------
MUL_0150|M.ulcerans_Agy99 ----------------------------------
MAV_1250|M.avium_104 ----------------------------------
MSMEG_4477|M.smegmatis_MC2_155 TATRRADRAVAAVAKRTPWALRGVARLTMSATRR
MLBr_01399|M.leprae_Br4923 ----------------------------------
MAB_4771|M.abscessus_ATCC_1997 ----------------------------------