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M. tuberculosis H37Rv Rv1840c (PE_PGRS34)

annotation: PE-PGRS FAMILY PROTEIN
coordinates: 2087971 - 2089518
length: 515

SFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGADEVSAAVADLFGAHAQAYQALSAQAAL
FHEQFVHAMTAGAGAYAGAEAADAAALDVLNGPFQALFGRPLIGDGANGAPGQPGGPGGLLYGNGGNGGN
GGIGQPGGAGGDAGLIGNGGNGGIGGPGATGLAGGAGGVGGLLFGDGGNGGAGGLGTGPVGATGGIGGPG
GAAVGLFGHGGAGGAGGLGKAGFAGGAGGTGGTGGLLYGNGGNGGNVPSGAADGGAGGDARLIGNGGDGG
SVGAAPTGIGNGGNGGNGGWLYGDGGSGGSTLQGFSDGGTGGNAGMFGDGGNGGFSFFDGNGGDGGTGGT
LIGNGGDGGNSVQTDGFLRGHGGDGGNAVGLIGNGGAGGAGSAGTGVFAPGGGSGGNGGNGALLVGNGGA
GGSGGPTQIPSVAVPVTGAGGTGGNGGTAGLIGNGGNGGAAGVSGDGTPGTGGNGGYAQLIGDGGDGGPG
DSGGPGGSGGTGGTLAGQNGSPGG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1840cPE_PGRS34-100% (515)PE-PGRS FAMILY PROTEIN
M. tuberculosis H37RvRv2162cPE_PGRS38e-14855.90% (542) PE-PGRS family protein
M. tuberculosis H37RvRv1396cPE_PGRS25e-14554.69% (576) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1871cPE_PGRS340.087.96% (515) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-1e-8344.19% (525) triple helix repeat-containing collagen
M. leprae Br4923MLBr_01183-2e-1337.50% (96) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-6e-3835.15% (404) hypothetical protein MAB_4284c
M. marinum MMMAR_2709-1e-17361.75% (536) PE-PGRS family protein, PE_PGRS34_1
M. avium 104MAV_4827-7e-2041.85% (184) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-2e-7138.49% (569) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_4332-2e-4036.26% (353) PUTATIVE -
M. ulcerans Agy99MUL_3056-0.063.57% (549) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-9e-8441.32% (576) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------------MSIIDFIL
MAV_4827|M.avium_104                ------------------------MNIVLGVSMAPSSIQMVVLEGEYADG
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        ---------MSFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMG---
Mb1871c|M.bovis_AF2122/97           ---------MSFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMG---
MUL_3056|M.ulcerans_Agy99           ---------MSFVVAAPDAVTAAVQDLASIGSAINVANAAAATPTTG---
MMAR_2709|M.marinum_M               ---------MSFVVAAPEMVQAAASDIASIGSTINMANVAATAPTTA---
TH_4332|M.thermoresistible__bu      ---------MPFITSGAAFVGGAAMLLAGPGGVSALEAAGSAPR------
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
MLBr_01183|M.leprae_Br4923          --------MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTE---
MAB_4284c|M.abscessus_ATCC_199      NLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYG-
MAV_4827|M.avium_104                ATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIG---
                                                                  .                   

Rv1840c|M.tuberculosis_H37Rv        -----------------------------VLAAGADEVSAAVADLFGAHA
Mb1871c|M.bovis_AF2122/97           -----------------------------VLAAGADEVSAAVADLFGAHA
MUL_3056|M.ulcerans_Agy99           -----------------------------ALAAAADEVSAAVAALFDGHA
MMAR_2709|M.marinum_M               -----------------------------VLAAGADEVSAVIAALFAAHG
TH_4332|M.thermoresistible__bu      --------------------------------------TVEYEYSLVACD
Mflv_5091|M.gilvum_PYR-GCK          GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1       GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155      LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
MLBr_01183|M.leprae_Br4923          -----------------------------IAPPAADDVSILLAHFFSGHG
MAB_4284c|M.abscessus_ATCC_199      -----------------------YQSQWVNTGNPIHDLSGNLQNYYAAQP
MAV_4827|M.avium_104                -------------------------VTWTDQLEAAALRDALAARRIDNVM
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        QAYQALSAQAALFHEQFVHAMTAGAGAYAGAEAADA--------------
Mb1871c|M.bovis_AF2122/97           QAYQALSAQAALFHEQFVHAMTAGAGAYAGAEAADA--------------
MUL_3056|M.ulcerans_Agy99           QAYQLIGAQAAEFHERFVRAMAAGAASYATAEAANAS----------PLQ
MMAR_2709|M.marinum_M               QAYQTLSAQAAQFHDQFVAAMTSAAGAYSGAEAANVS----------PLQ
TH_4332|M.thermoresistible__bu      STLPLMCEAGDSVGGLGGASHDRSAFSASALGMAS---------------
Mflv_5091|M.gilvum_PYR-GCK          VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1       VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155      GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
MLBr_01183|M.leprae_Br4923          RQYQAHASQGATNHQDLIQSLLTSSSAYAGTETAN---------------
MAB_4284c|M.abscessus_ATCC_199      DGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQ--------VMSPS
MAV_4827|M.avium_104                LVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTAT--------------L
                                                       .             .                

Rv1840c|M.tuberculosis_H37Rv        AALDVLNGPFQALFGRPLIGDGANGAPGQPGGPGG---------------
Mb1871c|M.bovis_AF2122/97           AALDVLNGPFQALFGRPLIGDGANGAPGQPGGPGG---------------
MUL_3056|M.ulcerans_Agy99           AALDAVNAPAQALLGRPLIGDGADGAPGQPGGAGG---------------
MMAR_2709|M.marinum_M               SLLDAANGETMAMLGRPLIGNGADGAPGQAGADGG---------------
TH_4332|M.thermoresistible__bu      FGPDWNPGGAFLG-------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----------------
Mvan_1264|M.vanbaalenii_PYR-1       VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----------------
MSMEG_0868|M.smegmatis_MC2_155      VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
MLBr_01183|M.leprae_Br4923          --HDSL--------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVG-------------
MAV_4827|M.avium_104                AVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAG--------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        ---------------LLYGNGGNGGNG--------------GIGQPGGAG
Mb1871c|M.bovis_AF2122/97           ---------------LLYGNGGNGGNG--------------GIGQPGGAG
MUL_3056|M.ulcerans_Agy99           ---------------LLYGNGGSGGNG--------------GIGQAGGAG
MMAR_2709|M.marinum_M               ---------------LLFGNGGNGGSG--------------LAGQAGGVG
TH_4332|M.thermoresistible__bu      ---------------LIGPGGLLIGDG---------------LNGTDAYI
Mflv_5091|M.gilvum_PYR-GCK          AVGAAGAAG------TVGTAGATGGTG---------------TGANGGAG
Mvan_1264|M.vanbaalenii_PYR-1       AIGTAGVAG------AAGTAGATGGTG---------------VGGNGGAG
MSMEG_0868|M.smegmatis_MC2_155      AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------GSNSGPIASGQG--------------STAVNGDVR
MAV_4827|M.avium_104                ----------LEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEE
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        GDAGLIGNGGNG-----------------GIGGPGATGLAGGAGGVGGLL
Mb1871c|M.bovis_AF2122/97           GDAGLIGNGGNG-----------------GIGGPGATGLAGGAG------
MUL_3056|M.ulcerans_Agy99           GDAGLIGNGGSG-----------------GIGGPDSTGLPGGAGGAGGWL
MMAR_2709|M.marinum_M               GAAGLIGNGGNG-----------------GAGGAGSNGLAGGSGGAGGWL
TH_4332|M.thermoresistible__bu      DENGVFHEATRG----------------------GNGGLLWGNGGKGGN-
Mflv_5091|M.gilvum_PYR-GCK          GVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGGQ-
Mvan_1264|M.vanbaalenii_PYR-1       QAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGGQ-
MSMEG_0868|M.smegmatis_MC2_155      TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      DSNIINADHGSNVG---------VDQSQTRVGGDYTNVSGHGSADIDKSV
MAV_4827|M.avium_104                PETALARGAALAAAN---------APLFASSTAALAYAQDPGTGAVDQYS
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        FGDGGNGGAGGLGTGPVGATGGIGGPGGAAVGLFGHGGAGGA--------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           LGDGGNGGIGGAGTG-IGGAGGSGGQGGAAAWLFGSGGTGGA--------
MMAR_2709|M.marinum_M               IGNGGNGGVGGIGSAAVGN-GGSGGAGGAAVGLFGNGGIGG---------
TH_4332|M.thermoresistible__bu      -GLDAGLYTVPDPDN-PGSTIQMYFEASDG--------------------
Mflv_5091|M.gilvum_PYR-GCK          -GTAGGTGGVGGIGG-AGSTGAVGGVGGKG----IQGGQG----------
Mvan_1264|M.vanbaalenii_PYR-1       -GTEGGTGGVGGVGG-VGATGGAGGVGGKG----IQGGQG----------
MSMEG_0868|M.smegmatis_MC2_155      SGADGEATGISAGGD-GGSATGADSLGGRGGTSWVQAGYGPTTGGKASGT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIGSHNQAN-------
MAV_4827|M.avium_104                LPDYLYVPVDPEPGDDELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRP
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --GGLGKAGFAGGAGGTGGTGGLLYG------------------------
Mb1871c|M.bovis_AF2122/97           ---GLGKAGFAGGAGGTGGTGGLLYG------------------------
MUL_3056|M.ulcerans_Agy99           --GGFGNSG-TGGPGGAGGTGGLLIG------------------------
MMAR_2709|M.marinum_M               --AGGGAEGLNGGAGGVGGIGGKLYG------------------------
TH_4332|M.thermoresistible__bu      ---------ADGGRGG----------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ---LQGGKGGDGGAGGKGGDADSMGS------------------AGATGG
Mvan_1264|M.vanbaalenii_PYR-1       ---LQGGQGGDGGTGGTGGDATSMGE------------------AGATGG
MSMEG_0868|M.smegmatis_MC2_155      AKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----IGTSTSAGGSAAVGGNAGLAGN----------------------AG
MAV_4827|M.avium_104                VLLVGSGLAVVGISAVLALEIALAIG----------------------IR
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        NGGNGGNVPSGAAD-------GGAGGDAR-LIGNGGDGGS----------
Mb1871c|M.bovis_AF2122/97           NGGNGGNVPSGAAD-------GGAGGDAR-LIGNGGDGGS----------
MUL_3056|M.ulcerans_Agy99           NGGNGGYDIQGGAF-------GGDGGNAR-LIGNGGDGGV----------
MMAR_2709|M.marinum_M               DGGAGGIGGMGAADPSAAGGAGGAGGSAVGWFGDGGAGGAG---------
TH_4332|M.thermoresistible__bu      -----------FLFG---------------NGGDGGNGGN----------
Mflv_5091|M.gilvum_PYR-GCK          KGGNGGNGGRGGLFG---------------KGGNAGNGAD----------
Mvan_1264|M.vanbaalenii_PYR-1       KGGNGGNGGRGSLFG---------------RGGNAGNGGN----------
MSMEG_0868|M.smegmatis_MC2_155      VGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LAGNAGLAGNAGLAG------NAGLAGNAGLAGNAGLAGN----------
MAV_4827|M.avium_104                TTGTVALQPTPNQHLIVPTEQAPAPPPVQASAPQPKISVPEP--------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------VGAAPTGIGNGGNGGNGGWLYGDGGSGGST----LQGFS---
Mb1871c|M.bovis_AF2122/97           --------VGAAPTGIGNGGNGGNGGWLYGDGGSGGST----LQGFS---
MUL_3056|M.ulcerans_Agy99           --------EAGGPG--TTGGDGGNGGWLLGNGGNGAAD----GGGAGSAA
MMAR_2709|M.marinum_M               ---GPVVPTAALGGLGGAGGAGGNGGQLWGDGGAGGLG----AFGQHG--
TH_4332|M.thermoresistible__bu      -----------------VGGKNGADPVTATVAADKS--------------
Mflv_5091|M.gilvum_PYR-GCK          ------------GGTGGAGGAGGTGG-TGGAGGTGG--------------
Mvan_1264|M.vanbaalenii_PYR-1       ------------GGTGGNGGNGGTGG-TGGNGGTGG--------------
MSMEG_0868|M.smegmatis_MC2_155      PAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKAN------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------AGLAGNAGLAGNAGLAGNAGLAGNAG------------
MAV_4827|M.avium_104                -VAAPKPLSPPVAAPLPAAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVP
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------DG--------GTGGNAGMFGDGGNGGFSFF
Mb1871c|M.bovis_AF2122/97           --------------------DG--------GTGGNAGMFGDGGNGGFSFF
MUL_3056|M.ulcerans_Agy99           GAGGNAGLIGNGGHGGLEHIDGTGGAGSIAGAGGDAGLFGSGGNGGFNGY
MMAR_2709|M.marinum_M               --------------------GGAG------GAGGNAGMVGNGGDGGTALG
TH_4332|M.thermoresistible__bu      ------------------------------------------------VA
Mflv_5091|M.gilvum_PYR-GCK          -------------------------------TGGTGGIGGAGSTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------------TGGTGGIGGAGSTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      ----------------------GQHSTGQTDTGGNGGRGGDGGTFVNAGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------------------LAGNAGLAGNAGLAGNAGL
MAV_4827|M.avium_104                VPVPVR--------------IPVPDPVSPPQLLAPPRLSVPQPVQPPVRV
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        DGNGGDGGTGGTLI--GNGGDGG-NSVQTDGFLRGHGGDGGNAVGLIGNG
Mb1871c|M.bovis_AF2122/97           DGNGGDGGTGGTLI--GNGGDGG-NSVQTDGFLRGHGGDGGNAVGLIGNG
MUL_3056|M.ulcerans_Agy99           QGVGGAGGAGGKLF--GDGGDGG-DCAESNGGI-GSGGRGGSAVGLIGNG
MMAR_2709|M.marinum_M               LAHGGDGGTGGTLI--GNGGAGG-GATMS------DAGDGGDAVGLIGSG
TH_4332|M.thermoresistible__bu      GGNGGNGGRGGLLF--GLGGNGGNGGWSTTSYLDARGGNGGNG----GLG
Mflv_5091|M.gilvum_PYR-GCK          GGTGGTGGTGGTG---GTGGTGGTGGTGGKGGTGGTGGAGGTG----GDG
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGTGGTGGTG---GTGGTGGTGGTGGKGGTGGTGGDGGTG----GTG
MSMEG_0868|M.smegmatis_MC2_155      NGNGGAGGAGGVSE--GEGGTGGHGGDGGRGGDGALGGNGGTGGVGLGNG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAAVAGNAAVAG
MAV_4827|M.avium_104                PQPPSPPQVGGTVPQ-SPPQHQTPPGEGTPPKPDGPGNYGGGHVPTPGAG
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        GAGGAGSA-------------GTGVFAPGGGSG---------------GN
Mb1871c|M.bovis_AF2122/97           GAGGAGSA-------------GTGVFAPGGGSG---------------GN
MUL_3056|M.ulcerans_Agy99           GAGGVG---------------GVGRNANAGGSG---------------GS
MMAR_2709|M.marinum_M               GAGGIG---------------GAALAGGTGGTG---------------GD
TH_4332|M.thermoresistible__bu      GVLRPGGLLSLLLP--------SGAASEPGGLF-------------TGGN
Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGTGGTG---------GTGGTGGTGGAG-----------DGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGTGGTG---------GTGGTGGTGGAG-----------DGLGGT
MSMEG_0868|M.smegmatis_MC2_155      GKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      NAAVAGNAAVGG-------VLNTGVSGAIGGSS--------------HVG
MAV_4827|M.avium_104                GSGGSGG--------------GHVPTPGAGGSG---------------GS
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        GGNGALLVGNGGAGGSGG--------------------PTQIPSVAVPVT
Mb1871c|M.bovis_AF2122/97           GGNGALLVGNGGAGGSGG--------------------PTQIPSVAVPVT
MUL_3056|M.ulcerans_Agy99           GGNAAWLFGDGGAGGSGG--------------------SSD--------T
MMAR_2709|M.marinum_M               GGHGAKLLGNGGAGGAGG--------------------AAG------GGL
TH_4332|M.thermoresistible__bu      GGNGGLAIANHWVG-----------------------ITDGVPGPDDDAV
Mflv_5091|M.gilvum_PYR-GCK          GGTGG----TGGQGGQGGQGG-----------------TGGTGGQGG-LG
Mvan_1264|M.vanbaalenii_PYR-1       GGTGG----TGGFGGQGGQGG-----------------TGGTGGQGG-LG
MSMEG_0868|M.smegmatis_MC2_155      GGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GAINESLGGSGSVGGSTAVGG------------------GAHTGVGGGVS
MAV_4827|M.avium_104                GGGHVPTPGTGGPGGTGG--------------------SGGGHVPTPGAG
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        GAGGTG-----------------------GNGGTAGLIGNGGNGGAAGVS
Mb1871c|M.bovis_AF2122/97           GAGGTG-----------------------GNGGTAGLIGNGGNGGAAGVS
MUL_3056|M.ulcerans_Agy99           AASGAG-----------------------GNGGTAALIGNGGAGGDAGVS
MMAR_2709|M.marinum_M               GNGGNG-----------------------GNGGEAALIGNGGAGGDAGTS
TH_4332|M.thermoresistible__bu      SSSAYG-----------------------GHGGHGAGPGSGGNGGSAVAN
Mflv_5091|M.gilvum_PYR-GCK          GGGGTG-----------------------GQGGTGGTGGQGGTGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1       GVGGTG-----------------------GTGGTGGTGGQGGTGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155      ATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIE
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TGVGVG-----------------------SHVGGGISESLGGSGSVGGST
MAV_4827|M.avium_104                TPGGSG-------------------------GGHLPFPGAGSTPGGSGGG
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        GDG---------TPGTGGNGGYAQLIGDGGDGGPGDSGGPGGSGGTGGTL
Mb1871c|M.bovis_AF2122/97           GDG---------TPGTGGNGGYAQLIGDGGDGGPGDSGGPGGSGGTGGTL
MUL_3056|M.ulcerans_Agy99           FAG---------MAGPGGNGGDARLIGDGGDGG---RGAPGGAGGMGGSL
MMAR_2709|M.marinum_M               GSSR--------NFGDGGNGGDAQLIGNGGNGGRGGVNGTGGTGGNGGTV
TH_4332|M.thermoresistible__bu      SLG-------NAIAGNGGDAGRFVLIGPGGNGGNGGTGLXXXPRPRR---
Mflv_5091|M.gilvum_PYR-GCK          GTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGA
Mvan_1264|M.vanbaalenii_PYR-1       GTG--------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGA
MSMEG_0868|M.smegmatis_MC2_155      ANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AVG--------GGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGST
MAV_4827|M.avium_104                HLP---------TPGAGTPGG--GLGGFGGGHAPAPGGGLGGGGGHAPAP
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        AGQNG----------------------------------SPGG-------
Mb1871c|M.bovis_AF2122/97           AGQNG----------------------------------SPGG-------
MUL_3056|M.ulcerans_Agy99           FGQDG----------------------------------SNGA-------
MMAR_2709|M.marinum_M               AGANG----------------------------------TDGP-------
TH_4332|M.thermoresistible__bu      -----------------------------RRNHRRTRRRPNGRRPRPPPG
Mflv_5091|M.gilvum_PYR-GCK          GGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGATG
Mvan_1264|M.vanbaalenii_PYR-1       GGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGATG
MSMEG_0868|M.smegmatis_MC2_155      TGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AVGGG--------------------------------AHTGVGGGVNTGV
MAV_4827|M.avium_104                GGGLG--------------------------------GFGGGHSGGGLGG
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      R-------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          AQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG-------
Mvan_1264|M.vanbaalenii_PYR-1       AQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG-------
MSMEG_0868|M.smegmatis_MC2_155      GVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GVGSHVGGGISESLGGSGSVGGSTAVGGGAHTSAINDALGGSGSVGGSTA
MAV_4827|M.avium_104                LGGGHK--------------------------------------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------A
Mvan_1264|M.vanbaalenii_PYR-1       ----TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------A
MSMEG_0868|M.smegmatis_MC2_155      IHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAV
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHA
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          AGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDGGKGG
Mvan_1264|M.vanbaalenii_PYR-1       AGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155      AGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      QGHASETAHTTLPGAEHH--------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1871c|M.bovis_AF2122/97           --------------------------------------------------
MUL_3056|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2709|M.marinum_M               --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          AGAE--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSG
Mvan_1264|M.vanbaalenii_PYR-1       DGSE--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSG
MSMEG_0868|M.smegmatis_MC2_155      DGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1840c|M.tuberculosis_H37Rv        --------
Mb1871c|M.bovis_AF2122/97           --------
MUL_3056|M.ulcerans_Agy99           --------
MMAR_2709|M.marinum_M               --------
TH_4332|M.thermoresistible__bu      --------
Mflv_5091|M.gilvum_PYR-GCK          GAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1       GAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155      GTTGANNP
MLBr_01183|M.leprae_Br4923          --------
MAB_4284c|M.abscessus_ATCC_199      --------
MAV_4827|M.avium_104                --------