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M. tuberculosis H37Rv Rv1396c (PE_PGRS25)

annotation: PE-PGRS FAMILY PROTEIN
coordinates: 1572127 - 1573857
length: 576

SFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAAGADEVSAAVAALFSGHAQTYQALRTQAAA
FHQQIVQTLTSTAGAYASAEAANVEQQLLGAINAPTMALLGRPLIGHGADGAPGTGQAGGAGGILYGNGG
NGGSGATGQAGGAGGAAGLIGHGGAGGLGGTGASGGAGGAGGWLWGNGGAGGNGGVGVAGDPGGVGGAGG
AGGAAGLWGSGGSGGTGGQGGVGGGKSGDGGTGGIGGAGGGGGWLHGDGGAGGHGGQGGTGVSSGGNGGA
GGTGGDGRGLSGSGGAGGRGGQTGVGGKVGENNFGGAGGAGGTGGLIGNGGAGGNGGQGAISGAGGAGGN
AWLIGDGGAGGNGGDIRGQGGGAGGAGGAGGQLIGNGGTGGAGGTVTSPNGLGGAGGAGGSAGLIGHGGT
GGAGGHSAQGPDGNGGIGGAGGAGGNGGQLYGTGGTGGTGGKGGDGFGVFGKGGAGGTGGRGGAAGLIGD
AGTGGTGGKGGTAGEDGTGGNGGTGGNGGAAVLIGNGGGGGAGGNGGAGNDGTPGNGGGGGVGGTGGTLF
GQPGQPGPPGQPGPA*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1396cPE_PGRS25-100% (576)PE-PGRS FAMILY PROTEIN
M. tuberculosis H37RvRv0124PE_PGRS20.069.70% (495) PE-PGRS family protein
M. tuberculosis H37RvRv1091PE_PGRS22e-17752.83% (689) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1431cPE_PGRS250.084.62% (468) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-1e-12052.88% (452) triple helix repeat-containing collagen
M. leprae Br4923MLBr_01183-2e-1644.57% (92) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-8e-4433.58% (405) hypothetical protein MAB_4284c
M. marinum MMMAR_4224-1e-17758.35% (605) PE-PGRS family protein
M. avium 104MAV_4827-7e-2543.45% (168) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-9338.92% (632) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-3e-4240.92% (303) PUTATIVE -
M. ulcerans Agy99MUL_1145-1e-16447.05% (763) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-1e-11750.94% (479) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
Rv1396c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1431c|M.bovis_AF2122/97           --------------------------------------------------
MUL_1145|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
Rv1396c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1431c|M.bovis_AF2122/97           --------------------------------------------------
MUL_1145|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------MSIIDFILNLFRDPVEAASYVADPEAALANAG------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
Rv1396c|M.tuberculosis_H37Rv        -----------------------------------------MS-FLFAQP
Mb1431c|M.bovis_AF2122/97           -----------------------------------------MS-FLFAQP
MUL_1145|M.ulcerans_Agy99           -----------------------------------------MS-YVVASP
MLBr_01183|M.leprae_Br4923          -----------------------------------------MPLFLNAEP
MMAR_4224|M.marinum_M               -----------------------------------------MS-FLVTAP
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------LSAVSAAQVGAVMP
MAV_4827|M.avium_104                -------------------------------------MNIVLGVSMAPSS
                                                                                      

TH_3810|M.thermoresistible__bu      ------------------------------------------VDGDGGSG
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
Rv1396c|M.tuberculosis_H37Rv        ----------------------------------------EMLGAAATDL
Mb1431c|M.bovis_AF2122/97           ----------------------------------------EMLGAAATDL
MUL_1145|M.ulcerans_Agy99           ----------------------------------------EYVAAAASDL
MLBr_01183|M.leprae_Br4923          ----------------------------------------QALTAAANTL
MMAR_4224|M.marinum_M               ----------------------------------------EILAAAATDL
MAB_4284c|M.abscessus_ATCC_199      ----------------------------------------VVAESVASNY
MAV_4827|M.avium_104                ----------------------------------------IQMVVLEGEY
                                                                                      

TH_3810|M.thermoresistible__bu      GR-----------------------------------------TGLFSKL
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
Rv1396c|M.tuberculosis_H37Rv        AS----------------------------------------IGSAISTA
Mb1431c|M.bovis_AF2122/97           AS----------------------------------------IGSAISTA
MUL_1145|M.ulcerans_Agy99           AG----------------------------------------IGSALSTA
MLBr_01183|M.leprae_Br4923          EG----------------------------------------LSAATVAS
MMAR_4224|M.marinum_M               DG----------------------------------------IGAAIGAA
MAB_4284c|M.abscessus_ATCC_199      G--------------------------------------YQSQWVNTGNP
MAV_4827|M.avium_104                AD-----------------------------------------GATVEED
                                                                                      

TH_3810|M.thermoresistible__bu      SRGGDGGDGGLGGNGGHGGGTGIISLLSLAGNGGNGGNGYRTTDNNALDG
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
Rv1396c|M.tuberculosis_H37Rv        NAAAAAATTRVLAAGADEVSAAVAALFSGHAQTYQALRTQAAAFHQQIVQ
Mb1431c|M.bovis_AF2122/97           NAAAAAATTRVLAAGADEVSAAVAALFSGHAQTYQALSTQAAAFHQQIVQ
MUL_1145|M.ulcerans_Agy99           NAAAAAPTIEVLAAGADEVSAAIAAFFGAHAQAYQALSEQASAFHLQFVQ
MLBr_01183|M.leprae_Br4923          NAAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQ
MMAR_4224|M.marinum_M               NAAAAAPTTAVLAAGADEISAAMASLFTAHAQAYQGLSVQVGAFHNQFVQ
MAB_4284c|M.abscessus_ATCC_199      IHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIAS
MAV_4827|M.avium_104                AIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA
                                                                                      

TH_3810|M.thermoresistible__bu      GH-----GGNGGNVGFFSLFNLG-----------GAGGWGGSGVDGVDVV
Mflv_5091|M.gilvum_PYR-GCK          GN-----GGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGA
Mvan_1264|M.vanbaalenii_PYR-1       GD-----GGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGA
MSMEG_0868|M.smegmatis_MC2_155      LD-----GGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGT
Rv1396c|M.tuberculosis_H37Rv        TL-----TSTAGAYASAEAANVE-------QQLLGAINAPTMALLGRPLI
Mb1431c|M.bovis_AF2122/97           TL-----TSTAGAYASAEAANVE-------QQLLGAINAPTMALLGRPLI
MUL_1145|M.ulcerans_Agy99           AM-----TAGAGAYAGAEAVNASPL-----QAALDVLNAPAQALFGRPLI
MLBr_01183|M.leprae_Br4923          SL-----LTSSSAYAGTETANHD-------------------SL------
MMAR_4224|M.marinum_M               AL-----TGAGGAYAAAEAANVSPLQAAA-QDMLTAIRAPAQALLGRPLI
MAB_4284c|M.abscessus_ATCC_199      GNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSG
MAV_4827|M.avium_104                AALR----DALAARRIDNVMLVS------------AFLAAAALAQNVGGA
                                                                                      

TH_3810|M.thermoresistible__bu      GGNPDGGTPGAHGESHTPGVYTDRQGE-DGEDGTGTGIGGRG--------
Mflv_5091|M.gilvum_PYR-GCK          TGA-TGVTSGVVGGNGEDAVGYGATGA-AGAAGAAGAAGAAG--------
Mvan_1264|M.vanbaalenii_PYR-1       TGA-TGVTSNVTGGNGADAVGYGATGA-AGAAGAAGAAGKAG--------
MSMEG_0868|M.smegmatis_MC2_155      GGG-TGGTGGIGGTGGGLFGLLGHSGS-TGAAGAAGNGGDGGNGGFGYVL
Rv1396c|M.tuberculosis_H37Rv        GHG-ADGAPGTGQAGGAGGILYGNGGN-GGSGATG-QAGGAG--------
Mb1431c|M.bovis_AF2122/97           GHG-ADGAPGTGQAGGAGGILYGNGGN-GGSGATG-QAGGAG--------
MUL_1145|M.ulcerans_Agy99           GDG-AGGAP--GQSGGDGGLLYGNGGN-GGNGGVG-QAGGAG--------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               GNG-ADGAP--GQAGGDGGLLYGNGGN-GGTSTTAGVAGGAG--------
MAB_4284c|M.abscessus_ATCC_199      PIASGQGSTAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTN------
MAV_4827|M.avium_104                MGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYG--------
                                                                                      

TH_3810|M.thermoresistible__bu      --------GNGGSSSGTHPMAEDGEHVKALDGRPGLD-------------
Mflv_5091|M.gilvum_PYR-GCK          ------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------
Mvan_1264|M.vanbaalenii_PYR-1       ------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------
MSMEG_0868|M.smegmatis_MC2_155      IAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGAN
Rv1396c|M.tuberculosis_H37Rv        --------GAAGLIGHGGAGGLGG---TGASGGAGGAGGWLWG-------
Mb1431c|M.bovis_AF2122/97           --------GAAGLIGHGGAGGLGG---TGASGGAGGAGGWLWG-------
MUL_1145|M.ulcerans_Agy99           --------GAAGLIGNGGSGGIGGPGTTGLAGGAGGSGGWLFG-------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               --------GSAGLIGNGGAGGGGG---AGAVGGNGGAGGWLFG-------
MAB_4284c|M.abscessus_ATCC_199      ------VSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTN------
MAV_4827|M.avium_104                -----------DAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAP-----
                                                                                      

TH_3810|M.thermoresistible__bu      ---------GGNGSHG--------------------------------GN
Mflv_5091|M.gilvum_PYR-GCK          -------AVGAAGAAG------TVGTAGATGGTG---------------T
Mvan_1264|M.vanbaalenii_PYR-1       -------AIGTAGVAG------AAGTAGATGGTG---------------V
MSMEG_0868|M.smegmatis_MC2_155      GGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTAT
Rv1396c|M.tuberculosis_H37Rv        --------NGGAGGNG-----GVG-VAGDPGGVG--------------GA
Mb1431c|M.bovis_AF2122/97           --------NGGAGGNG-----GVG-VAGDPGGVG--------------GA
MUL_1145|M.ulcerans_Agy99           --------NGGTGGRG-----GIG-TTG-IGGIG--------------GT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               --------NGGAGGAG-----GATPGIGGGGGAG--------------GA
MAB_4284c|M.abscessus_ATCC_199      --------IGSGNTTNTEIGSHNQANIGTSTSAG--------------GS
MAV_4827|M.avium_104                --------LKQVLQTTTFLDVSVAEEPETALARG--------------AA
                                                                                      

TH_3810|M.thermoresistible__bu      GGHGGRGGFLGIGGSGGWG-------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGA
Mvan_1264|M.vanbaalenii_PYR-1       GGNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGV
MSMEG_0868|M.smegmatis_MC2_155      GGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGA
Rv1396c|M.tuberculosis_H37Rv        GGAGGAAGLWGSGGSGGTG----------------GQGG---VGGGKSGD
Mb1431c|M.bovis_AF2122/97           GGAGGAAGLWGSGGSGGTG----------------GQGG---VGGGKSGD
MUL_1145|M.ulcerans_Agy99           G--GDAVGLFGHGGTGGTG----------------GNGPDIFIAGGAGGS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               GGIGGAAGLFGNGGAGGVG----------------GDGG-----LNYYGD
MAB_4284c|M.abscessus_ATCC_199      AAVGGNAGLAGNAGLAGNAG-------------LAGNAGLAGNAGLAGNA
MAV_4827|M.avium_104                LAAANAPLFASSTAALAYAQ----------------DPGTGAVDQYSLPD
                                                                                      

TH_3810|M.thermoresistible__bu      --------GHGGNGGDTDADGGNGGDGGN---------------------
Mflv_5091|M.gilvum_PYR-GCK          GGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG----
Mvan_1264|M.vanbaalenii_PYR-1       GGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG----
MSMEG_0868|M.smegmatis_MC2_155      GGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTG
Rv1396c|M.tuberculosis_H37Rv        GGTG----GIGGAGGGGGWLHGDGGAG------GHGG----QGGTGVSS-
Mb1431c|M.bovis_AF2122/97           GGTG----GIGGAGGGGGWLHGDGGAG------GHGG----QGGTGVSS-
MUL_1145|M.ulcerans_Agy99           GGTGGLLFGNGGAGGGAPWGGADGGAGGDARLIGNGGGGGYEGSLGVLS-
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               GGVAG----AGGDGGRGGWLHGDGGDG------GAGG----DGGRGLP--
MAB_4284c|M.abscessus_ATCC_199      GLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG-------------
MAV_4827|M.avium_104                YLYVPVDPEPGDDELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRPVLL
                                                                                      

TH_3810|M.thermoresistible__bu      --------------GGSAGRGGTGGLRGVFGIN-----------------
Mflv_5091|M.gilvum_PYR-GCK          ---------LQGGKGGDGGAGGKGGDADSMGS------------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------LQGGQGGDGGTGGTGGDATSMGE------------------
MSMEG_0868|M.smegmatis_MC2_155      GKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGA
Rv1396c|M.tuberculosis_H37Rv        --------------GGNGGAGGTGGDGRGLSG------------------
Mb1431c|M.bovis_AF2122/97           --------------GGNGGAGGTGGDGRGLSG------------------
MUL_1145|M.ulcerans_Agy99           --------------GGTAGPGGDGGNAVGLIG------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               --------------GGDGGSGGAGG-GTGLWG------------------
MAB_4284c|M.abscessus_ATCC_199      -------------LAGNAGLAGNAGLAGNAGLAG----------------
MAV_4827|M.avium_104                VG------------SGLAVVGISAVLALEIALAIG---------------
                                                                                      

TH_3810|M.thermoresistible__bu      -----GGNGRAGLGGRGXXXX-----------------------------
Mflv_5091|M.gilvum_PYR-GCK          AGATGGKGGNGGNGGRGGLFG---------------KGGNAGNGAD----
Mvan_1264|M.vanbaalenii_PYR-1       AGATGGKGGNGGNGGRGSLFG---------------RGGNAGNGGN----
MSMEG_0868|M.smegmatis_MC2_155      ASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQ
Rv1396c|M.tuberculosis_H37Rv        ---SGGAGGRGGQ--TGVGGK-----------------------------
Mb1431c|M.bovis_AF2122/97           ---SGGAGGHGGQ--TGVGGK-----------------------------
MUL_1145|M.ulcerans_Agy99           ---NGGAGGAGAAGLSGVTGG-----------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               ---SGGAGGQGGTGGTGLNGN-----------------------------
MAB_4284c|M.abscessus_ATCC_199      ---NAGLAGNAGLAGNAGLAG-----------------------------
MAV_4827|M.avium_104                -IRTTGTVALQPTPNQHLIVP-----------------------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ------------------GGTGGAGGAGGTGG-TGGAGGTGG--------
Mvan_1264|M.vanbaalenii_PYR-1       ------------------GGTGGNGGNGGTGG-TGGNGGTGG--------
MSMEG_0868|M.smegmatis_MC2_155      AYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKAN
Rv1396c|M.tuberculosis_H37Rv        -----------------VGENN------FG--GAGGAGG--------TGG
Mb1431c|M.bovis_AF2122/97           -----------------VGENN------FG--GAGGAGG--------TGG
MUL_1145|M.ulcerans_Agy99           -----------------IGGNGGNGAQLFGNGGAGGAGGQSQLASGGTGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               -----------------APFADGQHPVILDG-GHGGTGGN-------GGA
MAB_4284c|M.abscessus_ATCC_199      -----------------NAGLAGNAGLAGNAGLAGNAAVAGN--------
MAV_4827|M.avium_104                -------------------TEQAPAPPPVQASAPQPKISVPEPVAAPKPL
                                                                                      

TH_3810|M.thermoresistible__bu      ---------GGGVGAAVRSGNGVFSGGGGTPSAGFGVPTTIQFPAGSCTS
Mflv_5091|M.gilvum_PYR-GCK          ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      GQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGH
Rv1396c|M.tuberculosis_H37Rv        ------LIGNGGAGGNGGQGAI--SGAGGAGGNAWLIGDGGAGGNGGDIR
Mb1431c|M.bovis_AF2122/97           ------LIGNGGAGG-----------------------------------
MUL_1145|M.ulcerans_Agy99           SGGMAALFGNGGAGGAAGVSLSGAPGTGGNGGSAQFMGDGDSGGLGDSGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               AGNGGLLFGNGGNGGLGGMGGGGGNGLPSTGVGGDGGDGGNGGTAGNGGW
MAB_4284c|M.abscessus_ATCC_199      ----AAVAGNAAVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGS
MAV_4827|M.avium_104                SPPVAAPLPAAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIP
                                                                                      

TH_3810|M.thermoresistible__bu      RAVS----------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGTGGKGG---------------------------TGGTGGAGGTG----
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGKGG---------------------------TGGTGGDGGTG----
MSMEG_0868|M.smegmatis_MC2_155      GGDGGRGG---------------------------DGALGGNGGTGGVGL
Rv1396c|M.tuberculosis_H37Rv        GQGGGAGG--------------------------AGGAGGQLIGNGGTGG
Mb1431c|M.bovis_AF2122/97           --------------------------------------------------
MUL_1145|M.ulcerans_Agy99           SAGAAGAGGLIGNPLDVVNAPTEALLGRPLIGDGADGAPGESGQDGGLLY
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               LIGNGGTG--------------------------GQGGAGFAGGTGADNV
MAB_4284c|M.abscessus_ATCC_199      VGGSTAVG---------------------------GGAHTGVGGGVSTGV
MAV_4827|M.avium_104                VPDPVSPP--------------------------QLLAPPRLSVPQPVQP
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GDGGTGGTGGTGGTG---------GTGGTGGTGGAG--------------
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGTGGTGGTG---------GTGGTGGTGGAG--------------
MSMEG_0868|M.smegmatis_MC2_155      GNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATG---
Rv1396c|M.tuberculosis_H37Rv        AGGTVTSPNGLGGAGGAGGSAGLIGHGGTGGAGGHSAQGPDGNGG-----
Mb1431c|M.bovis_AF2122/97           --------------------------------------------------
MUL_1145|M.ulcerans_Agy99           GNGGNGGNGLSGQAGGAGGAAGLIGNGGNGGIGGPGTTGMSGGAGGAGGW
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               SAGRPGGAGGTGGIGAGGGNAGLIGTGGSGGNGG----------------
MAB_4284c|M.abscessus_ATCC_199      GVGSHVGGGISESLGG----------------------------------
MAV_4827|M.avium_104                PVRVPQPPSPPQVGGTVPQSPPQHQTPPGEGTPP----------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -DGTGGTGGTGG----TGGQGGQGGQGG-----------------TGGTG
Mvan_1264|M.vanbaalenii_PYR-1       -DGLGGTGGTGG----TGGFGGQGGQGG-----------------TGGTG
MSMEG_0868|M.smegmatis_MC2_155      -TATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDG
Rv1396c|M.tuberculosis_H37Rv        IGGAGGAGGNGGQLYGTGGTGGTGGKGG----------------------
Mb1431c|M.bovis_AF2122/97           ----------------------TGGKGG----------------------
MUL_1145|M.ulcerans_Agy99           LIGNGGHGGIGGLGIGIGDSGGAGGAGG----------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               ----------------MGGHGGDSGYGD----------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------SGSVGGSTAVGG----------------------
MAV_4827|M.avium_104                ------------------KPDGPGNYGG----------------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GQGG-LGGGGGTG-----------------------GQGGTGGTGGQGGT
Mvan_1264|M.vanbaalenii_PYR-1       GQGG-LGGVGGTG-----------------------GTGGTGGTGGQGGT
MSMEG_0868|M.smegmatis_MC2_155      GNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGN
Rv1396c|M.tuberculosis_H37Rv        ---------------------------------------DGFGVFGKGGA
Mb1431c|M.bovis_AF2122/97           ---------------------------------------DGFGVFGKGGA
MUL_1145|M.ulcerans_Agy99           ---------------------------------------AAIGLFGNGGT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               ---------------------------------------QTGGQGGNGGM
MAB_4284c|M.abscessus_ATCC_199      ---------------------------------------GAHTGVGGGVS
MAV_4827|M.avium_104                ---------------------------------------GHVPTPGAGGS
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGP
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGP
MSMEG_0868|M.smegmatis_MC2_155      GGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANP
Rv1396c|M.tuberculosis_H37Rv        GGTG----------------------------------------------
Mb1431c|M.bovis_AF2122/97           GGTG----------------------------------------------
MUL_1145|M.ulcerans_Agy99           GGTGGYNQAFGAVSGVGGAGGAGGQWYGNGGDGGTSWGGAAAGAGGDAGL
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               GGAG----------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TGVG----------------------------------------------
MAV_4827|M.avium_104                GGSGGG--------------------------------------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------REGIMPSSRAASARAGAACASSTSRSRRSF
Mflv_5091|M.gilvum_PYR-GCK          GGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGK
Mvan_1264|M.vanbaalenii_PYR-1       GGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGK
MSMEG_0868|M.smegmatis_MC2_155      GSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGK
Rv1396c|M.tuberculosis_H37Rv        -------------------GRGGAAG-LIGDAGTGG------TGGKGGTA
Mb1431c|M.bovis_AF2122/97           -------------------GRGGAAG-LIGDAGTGG------TGGKGGTA
MUL_1145|M.ulcerans_Agy99           IDNGGDGDSAGVLRQNGIGGHGGAGGSLFGDGGDGGSAGFQSTAGDGGNA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               -------------------GAAGNGGLLLGSGSRGGDGGDGGNGGEGRGG
MAB_4284c|M.abscessus_ATCC_199      ---------------VGSHVGGGISESLGGSGSVGGSTAVGGGAHTGVGG
MAV_4827|M.avium_104                --------------HVPTPGAGGSGGSGGGHVPTPGTGGPGGTGGSGGGH
                                                                                      

TH_3810|M.thermoresistible__bu      CCSRA---------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GAQGATGAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG
Mvan_1264|M.vanbaalenii_PYR-1       GAQGATGAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG
MSMEG_0868|M.smegmatis_MC2_155      GGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAG
Rv1396c|M.tuberculosis_H37Rv        GEDGTGGNG--------------------------------------GTG
Mb1431c|M.bovis_AF2122/97           GEDGTGGNG--------------------------------------GTG
MUL_1145|M.ulcerans_Agy99           GLVGNGGNGGWAIYNSFAGDDGSGGTAIGNGGDGGANIVSSGFILGAGGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               FSVPQHGVGG-----------------------------------QGGTG
MAB_4284c|M.abscessus_ATCC_199      GVNTGVGVGSHVG-------------------------------------
MAV_4827|M.avium_104                VPTPGAGTP-----------------------------------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--
Mvan_1264|M.vanbaalenii_PYR-1       -----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--
MSMEG_0868|M.smegmatis_MC2_155      GFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSK
Rv1396c|M.tuberculosis_H37Rv        GN--------------GGAAV-LIGNGGGG--------------------
Mb1431c|M.bovis_AF2122/97           GN--------------GGAAV-LIGNGGGG--------------------
MUL_1145|M.ulcerans_Agy99           GN--------------GGNAVGLIGNGGAGGTGADGFSTALGSDGGNGGT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               GN--------------GSDGGWLYGDGGAG--------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------GGISESLGGSGSVGG-------------------
MAV_4827|M.avium_104                ----------------GGSGGGHLPFPGAG--------------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ------AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEG
Mvan_1264|M.vanbaalenii_PYR-1       ------AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEG
MSMEG_0868|M.smegmatis_MC2_155      IANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTG
Rv1396c|M.tuberculosis_H37Rv        --------GAGGNGG-------AGNDGTP---------------------
Mb1431c|M.bovis_AF2122/97           --------GAGGNGG-------AGNDGTP---------------------
MUL_1145|M.ulcerans_Agy99           GAWLLGNGGAGGSGGSTAGVHPAGDGGNSGM------------------S
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               --------GAGGNGG-------FGGSGVQN--------------------
MAB_4284c|M.abscessus_ATCC_199      ------STAVGGGAHTSAINDALGGSGSVGG------------------S
MAV_4827|M.avium_104                -------STPGGSGGGHLPTPGAGTPGG----------------------
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGS
Mvan_1264|M.vanbaalenii_PYR-1       GAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGS
MSMEG_0868|M.smegmatis_MC2_155      GNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGA
Rv1396c|M.tuberculosis_H37Rv        ---GNGGGGG------------VGGTGG--TLFGQPGQ--PGPPGQPGPA
Mb1431c|M.bovis_AF2122/97           ---GNGGGGG------------VGGTGG--TLFGQPGQ--PGPPGQPGPA
MUL_1145|M.ulcerans_Agy99           ALIGNGGAGGSAGVSPTGVFPSNGGSGGNAQLIGDGGDGGRGDSGGTGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MMAR_4224|M.marinum_M               ------GAGG------------DAGSGGDSRLIGDGGAAGAGGTGAPPGA
MAB_4284c|M.abscessus_ATCC_199      TAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQG
MAV_4827|M.avium_104                ---GLGGFGGG----------HAPAPGGGLGGGGGHAPAPGGGLGGFGGG
                                                                                      

TH_3810|M.thermoresistible__bu      --------------------
Mflv_5091|M.gilvum_PYR-GCK          GGSGGSGGAAGDSDD-----
Mvan_1264|M.vanbaalenii_PYR-1       GGAGGSGGAAGDSD------
MSMEG_0868|M.smegmatis_MC2_155      DGTPGTAGTTGANNP-----
Rv1396c|M.tuberculosis_H37Rv        --------------------
Mb1431c|M.bovis_AF2122/97           --------------------
MUL_1145|M.ulcerans_Agy99           GGTGGSLAGHDGSDGD----
MLBr_01183|M.leprae_Br4923          --------------------
MMAR_4224|M.marinum_M               DGHSGADGLLSAALGA----
MAB_4284c|M.abscessus_ATCC_199      HAQGHASETAHTTLPGAEHH
MAV_4827|M.avium_104                HSGGGLGGLGGGHK------