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SFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAAGADEVSAAVAALFSGHAQTYQALRTQAAA FHQQIVQTLTSTAGAYASAEAANVEQQLLGAINAPTMALLGRPLIGHGADGAPGTGQAGGAGGILYGNGG NGGSGATGQAGGAGGAAGLIGHGGAGGLGGTGASGGAGGAGGWLWGNGGAGGNGGVGVAGDPGGVGGAGG AGGAAGLWGSGGSGGTGGQGGVGGGKSGDGGTGGIGGAGGGGGWLHGDGGAGGHGGQGGTGVSSGGNGGA GGTGGDGRGLSGSGGAGGRGGQTGVGGKVGENNFGGAGGAGGTGGLIGNGGAGGNGGQGAISGAGGAGGN AWLIGDGGAGGNGGDIRGQGGGAGGAGGAGGQLIGNGGTGGAGGTVTSPNGLGGAGGAGGSAGLIGHGGT GGAGGHSAQGPDGNGGIGGAGGAGGNGGQLYGTGGTGGTGGKGGDGFGVFGKGGAGGTGGRGGAAGLIGD AGTGGTGGKGGTAGEDGTGGNGGTGGNGGAAVLIGNGGGGGAGGNGGAGNDGTPGNGGGGGVGGTGGTLF GQPGQPGPPGQPGPA*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1396c | PE_PGRS25 | - | 100% (576) | PE-PGRS FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv0124 | PE_PGRS2 | 0.0 | 69.70% (495) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | e-177 | 52.83% (689) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1431c | PE_PGRS25 | 0.0 | 84.62% (468) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-120 | 52.88% (452) | triple helix repeat-containing collagen |
M. leprae Br4923 | MLBr_01183 | - | 2e-16 | 44.57% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 8e-44 | 33.58% (405) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_4224 | - | 1e-177 | 58.35% (605) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 7e-25 | 43.45% (168) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-93 | 38.92% (632) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 3e-42 | 40.92% (303) | PUTATIVE - |
M. ulcerans Agy99 | MUL_1145 | - | 1e-164 | 47.05% (763) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-117 | 50.94% (479) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES Rv1396c|M.tuberculosis_H37Rv -------------------------------------------------- Mb1431c|M.bovis_AF2122/97 -------------------------------------------------- MUL_1145|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT Rv1396c|M.tuberculosis_H37Rv -------------------------------------------------- Mb1431c|M.bovis_AF2122/97 -------------------------------------------------- MUL_1145|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------MSIIDFILNLFRDPVEAASYVADPEAALANAG------ MAV_4827|M.avium_104 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA Rv1396c|M.tuberculosis_H37Rv -----------------------------------------MS-FLFAQP Mb1431c|M.bovis_AF2122/97 -----------------------------------------MS-FLFAQP MUL_1145|M.ulcerans_Agy99 -----------------------------------------MS-YVVASP MLBr_01183|M.leprae_Br4923 -----------------------------------------MPLFLNAEP MMAR_4224|M.marinum_M -----------------------------------------MS-FLVTAP MAB_4284c|M.abscessus_ATCC_199 ------------------------------------LSAVSAAQVGAVMP MAV_4827|M.avium_104 -------------------------------------MNIVLGVSMAPSS TH_3810|M.thermoresistible__bu ------------------------------------------VDGDGGSG Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP Rv1396c|M.tuberculosis_H37Rv ----------------------------------------EMLGAAATDL Mb1431c|M.bovis_AF2122/97 ----------------------------------------EMLGAAATDL MUL_1145|M.ulcerans_Agy99 ----------------------------------------EYVAAAASDL MLBr_01183|M.leprae_Br4923 ----------------------------------------QALTAAANTL MMAR_4224|M.marinum_M ----------------------------------------EILAAAATDL MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------VVAESVASNY MAV_4827|M.avium_104 ----------------------------------------IQMVVLEGEY TH_3810|M.thermoresistible__bu GR-----------------------------------------TGLFSKL Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA Rv1396c|M.tuberculosis_H37Rv AS----------------------------------------IGSAISTA Mb1431c|M.bovis_AF2122/97 AS----------------------------------------IGSAISTA MUL_1145|M.ulcerans_Agy99 AG----------------------------------------IGSALSTA MLBr_01183|M.leprae_Br4923 EG----------------------------------------LSAATVAS MMAR_4224|M.marinum_M DG----------------------------------------IGAAIGAA MAB_4284c|M.abscessus_ATCC_199 G--------------------------------------YQSQWVNTGNP MAV_4827|M.avium_104 AD-----------------------------------------GATVEED TH_3810|M.thermoresistible__bu SRGGDGGDGGLGGNGGHGGGTGIISLLSLAGNGGNGGNGYRTTDNNALDG Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG Rv1396c|M.tuberculosis_H37Rv NAAAAAATTRVLAAGADEVSAAVAALFSGHAQTYQALRTQAAAFHQQIVQ Mb1431c|M.bovis_AF2122/97 NAAAAAATTRVLAAGADEVSAAVAALFSGHAQTYQALSTQAAAFHQQIVQ MUL_1145|M.ulcerans_Agy99 NAAAAAPTIEVLAAGADEVSAAIAAFFGAHAQAYQALSEQASAFHLQFVQ MLBr_01183|M.leprae_Br4923 NAAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQ MMAR_4224|M.marinum_M NAAAAAPTTAVLAAGADEISAAMASLFTAHAQAYQGLSVQVGAFHNQFVQ MAB_4284c|M.abscessus_ATCC_199 IHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIAS MAV_4827|M.avium_104 AIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA TH_3810|M.thermoresistible__bu GH-----GGNGGNVGFFSLFNLG-----------GAGGWGGSGVDGVDVV Mflv_5091|M.gilvum_PYR-GCK GN-----GGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGA Mvan_1264|M.vanbaalenii_PYR-1 GD-----GGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGA MSMEG_0868|M.smegmatis_MC2_155 LD-----GGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGT Rv1396c|M.tuberculosis_H37Rv TL-----TSTAGAYASAEAANVE-------QQLLGAINAPTMALLGRPLI Mb1431c|M.bovis_AF2122/97 TL-----TSTAGAYASAEAANVE-------QQLLGAINAPTMALLGRPLI MUL_1145|M.ulcerans_Agy99 AM-----TAGAGAYAGAEAVNASPL-----QAALDVLNAPAQALFGRPLI MLBr_01183|M.leprae_Br4923 SL-----LTSSSAYAGTETANHD-------------------SL------ MMAR_4224|M.marinum_M AL-----TGAGGAYAAAEAANVSPLQAAA-QDMLTAIRAPAQALLGRPLI MAB_4284c|M.abscessus_ATCC_199 GNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSG MAV_4827|M.avium_104 AALR----DALAARRIDNVMLVS------------AFLAAAALAQNVGGA TH_3810|M.thermoresistible__bu GGNPDGGTPGAHGESHTPGVYTDRQGE-DGEDGTGTGIGGRG-------- Mflv_5091|M.gilvum_PYR-GCK TGA-TGVTSGVVGGNGEDAVGYGATGA-AGAAGAAGAAGAAG-------- Mvan_1264|M.vanbaalenii_PYR-1 TGA-TGVTSNVTGGNGADAVGYGATGA-AGAAGAAGAAGKAG-------- MSMEG_0868|M.smegmatis_MC2_155 GGG-TGGTGGIGGTGGGLFGLLGHSGS-TGAAGAAGNGGDGGNGGFGYVL Rv1396c|M.tuberculosis_H37Rv GHG-ADGAPGTGQAGGAGGILYGNGGN-GGSGATG-QAGGAG-------- Mb1431c|M.bovis_AF2122/97 GHG-ADGAPGTGQAGGAGGILYGNGGN-GGSGATG-QAGGAG-------- MUL_1145|M.ulcerans_Agy99 GDG-AGGAP--GQSGGDGGLLYGNGGN-GGNGGVG-QAGGAG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M GNG-ADGAP--GQAGGDGGLLYGNGGN-GGTSTTAGVAGGAG-------- MAB_4284c|M.abscessus_ATCC_199 PIASGQGSTAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTN------ MAV_4827|M.avium_104 MGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYG-------- TH_3810|M.thermoresistible__bu --------GNGGSSSGTHPMAEDGEHVKALDGRPGLD------------- Mflv_5091|M.gilvum_PYR-GCK ------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--------- Mvan_1264|M.vanbaalenii_PYR-1 ------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--------- MSMEG_0868|M.smegmatis_MC2_155 IAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGAN Rv1396c|M.tuberculosis_H37Rv --------GAAGLIGHGGAGGLGG---TGASGGAGGAGGWLWG------- Mb1431c|M.bovis_AF2122/97 --------GAAGLIGHGGAGGLGG---TGASGGAGGAGGWLWG------- MUL_1145|M.ulcerans_Agy99 --------GAAGLIGNGGSGGIGGPGTTGLAGGAGGSGGWLFG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M --------GSAGLIGNGGAGGGGG---AGAVGGNGGAGGWLFG------- MAB_4284c|M.abscessus_ATCC_199 ------VSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTN------ MAV_4827|M.avium_104 -----------DAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAP----- TH_3810|M.thermoresistible__bu ---------GGNGSHG--------------------------------GN Mflv_5091|M.gilvum_PYR-GCK -------AVGAAGAAG------TVGTAGATGGTG---------------T Mvan_1264|M.vanbaalenii_PYR-1 -------AIGTAGVAG------AAGTAGATGGTG---------------V MSMEG_0868|M.smegmatis_MC2_155 GGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTAT Rv1396c|M.tuberculosis_H37Rv --------NGGAGGNG-----GVG-VAGDPGGVG--------------GA Mb1431c|M.bovis_AF2122/97 --------NGGAGGNG-----GVG-VAGDPGGVG--------------GA MUL_1145|M.ulcerans_Agy99 --------NGGTGGRG-----GIG-TTG-IGGIG--------------GT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M --------NGGAGGAG-----GATPGIGGGGGAG--------------GA MAB_4284c|M.abscessus_ATCC_199 --------IGSGNTTNTEIGSHNQANIGTSTSAG--------------GS MAV_4827|M.avium_104 --------LKQVLQTTTFLDVSVAEEPETALARG--------------AA TH_3810|M.thermoresistible__bu GGHGGRGGFLGIGGSGGWG------------------------------- Mflv_5091|M.gilvum_PYR-GCK GANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGA Mvan_1264|M.vanbaalenii_PYR-1 GGNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGV MSMEG_0868|M.smegmatis_MC2_155 GGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGA Rv1396c|M.tuberculosis_H37Rv GGAGGAAGLWGSGGSGGTG----------------GQGG---VGGGKSGD Mb1431c|M.bovis_AF2122/97 GGAGGAAGLWGSGGSGGTG----------------GQGG---VGGGKSGD MUL_1145|M.ulcerans_Agy99 G--GDAVGLFGHGGTGGTG----------------GNGPDIFIAGGAGGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M GGIGGAAGLFGNGGAGGVG----------------GDGG-----LNYYGD MAB_4284c|M.abscessus_ATCC_199 AAVGGNAGLAGNAGLAGNAG-------------LAGNAGLAGNAGLAGNA MAV_4827|M.avium_104 LAAANAPLFASSTAALAYAQ----------------DPGTGAVDQYSLPD TH_3810|M.thermoresistible__bu --------GHGGNGGDTDADGGNGGDGGN--------------------- Mflv_5091|M.gilvum_PYR-GCK GGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG---- Mvan_1264|M.vanbaalenii_PYR-1 GGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG---- MSMEG_0868|M.smegmatis_MC2_155 GGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTG Rv1396c|M.tuberculosis_H37Rv GGTG----GIGGAGGGGGWLHGDGGAG------GHGG----QGGTGVSS- Mb1431c|M.bovis_AF2122/97 GGTG----GIGGAGGGGGWLHGDGGAG------GHGG----QGGTGVSS- MUL_1145|M.ulcerans_Agy99 GGTGGLLFGNGGAGGGAPWGGADGGAGGDARLIGNGGGGGYEGSLGVLS- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M GGVAG----AGGDGGRGGWLHGDGGDG------GAGG----DGGRGLP-- MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG------------- MAV_4827|M.avium_104 YLYVPVDPEPGDDELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRPVLL TH_3810|M.thermoresistible__bu --------------GGSAGRGGTGGLRGVFGIN----------------- Mflv_5091|M.gilvum_PYR-GCK ---------LQGGKGGDGGAGGKGGDADSMGS------------------ Mvan_1264|M.vanbaalenii_PYR-1 ---------LQGGQGGDGGTGGTGGDATSMGE------------------ MSMEG_0868|M.smegmatis_MC2_155 GKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGA Rv1396c|M.tuberculosis_H37Rv --------------GGNGGAGGTGGDGRGLSG------------------ Mb1431c|M.bovis_AF2122/97 --------------GGNGGAGGTGGDGRGLSG------------------ MUL_1145|M.ulcerans_Agy99 --------------GGTAGPGGDGGNAVGLIG------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M --------------GGDGGSGGAGG-GTGLWG------------------ MAB_4284c|M.abscessus_ATCC_199 -------------LAGNAGLAGNAGLAGNAGLAG---------------- MAV_4827|M.avium_104 VG------------SGLAVVGISAVLALEIALAIG--------------- TH_3810|M.thermoresistible__bu -----GGNGRAGLGGRGXXXX----------------------------- Mflv_5091|M.gilvum_PYR-GCK AGATGGKGGNGGNGGRGGLFG---------------KGGNAGNGAD---- Mvan_1264|M.vanbaalenii_PYR-1 AGATGGKGGNGGNGGRGSLFG---------------RGGNAGNGGN---- MSMEG_0868|M.smegmatis_MC2_155 ASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQ Rv1396c|M.tuberculosis_H37Rv ---SGGAGGRGGQ--TGVGGK----------------------------- Mb1431c|M.bovis_AF2122/97 ---SGGAGGHGGQ--TGVGGK----------------------------- MUL_1145|M.ulcerans_Agy99 ---NGGAGGAGAAGLSGVTGG----------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M ---SGGAGGQGGTGGTGLNGN----------------------------- MAB_4284c|M.abscessus_ATCC_199 ---NAGLAGNAGLAGNAGLAG----------------------------- MAV_4827|M.avium_104 -IRTTGTVALQPTPNQHLIVP----------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------------GGTGGAGGAGGTGG-TGGAGGTGG-------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------GGTGGNGGNGGTGG-TGGNGGTGG-------- MSMEG_0868|M.smegmatis_MC2_155 AYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKAN Rv1396c|M.tuberculosis_H37Rv -----------------VGENN------FG--GAGGAGG--------TGG Mb1431c|M.bovis_AF2122/97 -----------------VGENN------FG--GAGGAGG--------TGG MUL_1145|M.ulcerans_Agy99 -----------------IGGNGGNGAQLFGNGGAGGAGGQSQLASGGTGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M -----------------APFADGQHPVILDG-GHGGTGGN-------GGA MAB_4284c|M.abscessus_ATCC_199 -----------------NAGLAGNAGLAGNAGLAGNAAVAGN-------- MAV_4827|M.avium_104 -------------------TEQAPAPPPVQASAPQPKISVPEPVAAPKPL TH_3810|M.thermoresistible__bu ---------GGGVGAAVRSGNGVFSGGGGTPSAGFGVPTTIQFPAGSCTS Mflv_5091|M.gilvum_PYR-GCK ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGH Rv1396c|M.tuberculosis_H37Rv ------LIGNGGAGGNGGQGAI--SGAGGAGGNAWLIGDGGAGGNGGDIR Mb1431c|M.bovis_AF2122/97 ------LIGNGGAGG----------------------------------- MUL_1145|M.ulcerans_Agy99 SGGMAALFGNGGAGGAAGVSLSGAPGTGGNGGSAQFMGDGDSGGLGDSGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M AGNGGLLFGNGGNGGLGGMGGGGGNGLPSTGVGGDGGDGGNGGTAGNGGW MAB_4284c|M.abscessus_ATCC_199 ----AAVAGNAAVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGS MAV_4827|M.avium_104 SPPVAAPLPAAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIP TH_3810|M.thermoresistible__bu RAVS---------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGTGGKGG---------------------------TGGTGGAGGTG---- Mvan_1264|M.vanbaalenii_PYR-1 GGTGGKGG---------------------------TGGTGGDGGTG---- MSMEG_0868|M.smegmatis_MC2_155 GGDGGRGG---------------------------DGALGGNGGTGGVGL Rv1396c|M.tuberculosis_H37Rv GQGGGAGG--------------------------AGGAGGQLIGNGGTGG Mb1431c|M.bovis_AF2122/97 -------------------------------------------------- MUL_1145|M.ulcerans_Agy99 SAGAAGAGGLIGNPLDVVNAPTEALLGRPLIGDGADGAPGESGQDGGLLY MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M LIGNGGTG--------------------------GQGGAGFAGGTGADNV MAB_4284c|M.abscessus_ATCC_199 VGGSTAVG---------------------------GGAHTGVGGGVSTGV MAV_4827|M.avium_104 VPDPVSPP--------------------------QLLAPPRLSVPQPVQP TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GDGGTGGTGGTGGTG---------GTGGTGGTGGAG-------------- Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTGGTG---------GTGGTGGTGGAG-------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATG--- Rv1396c|M.tuberculosis_H37Rv AGGTVTSPNGLGGAGGAGGSAGLIGHGGTGGAGGHSAQGPDGNGG----- Mb1431c|M.bovis_AF2122/97 -------------------------------------------------- MUL_1145|M.ulcerans_Agy99 GNGGNGGNGLSGQAGGAGGAAGLIGNGGNGGIGGPGTTGMSGGAGGAGGW MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M SAGRPGGAGGTGGIGAGGGNAGLIGTGGSGGNGG---------------- MAB_4284c|M.abscessus_ATCC_199 GVGSHVGGGISESLGG---------------------------------- MAV_4827|M.avium_104 PVRVPQPPSPPQVGGTVPQSPPQHQTPPGEGTPP---------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -DGTGGTGGTGG----TGGQGGQGGQGG-----------------TGGTG Mvan_1264|M.vanbaalenii_PYR-1 -DGLGGTGGTGG----TGGFGGQGGQGG-----------------TGGTG MSMEG_0868|M.smegmatis_MC2_155 -TATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDG Rv1396c|M.tuberculosis_H37Rv IGGAGGAGGNGGQLYGTGGTGGTGGKGG---------------------- Mb1431c|M.bovis_AF2122/97 ----------------------TGGKGG---------------------- MUL_1145|M.ulcerans_Agy99 LIGNGGHGGIGGLGIGIGDSGGAGGAGG---------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M ----------------MGGHGGDSGYGD---------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------SGSVGGSTAVGG---------------------- MAV_4827|M.avium_104 ------------------KPDGPGNYGG---------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GQGG-LGGGGGTG-----------------------GQGGTGGTGGQGGT Mvan_1264|M.vanbaalenii_PYR-1 GQGG-LGGVGGTG-----------------------GTGGTGGTGGQGGT MSMEG_0868|M.smegmatis_MC2_155 GNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGN Rv1396c|M.tuberculosis_H37Rv ---------------------------------------DGFGVFGKGGA Mb1431c|M.bovis_AF2122/97 ---------------------------------------DGFGVFGKGGA MUL_1145|M.ulcerans_Agy99 ---------------------------------------AAIGLFGNGGT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M ---------------------------------------QTGGQGGNGGM MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------GAHTGVGGGVS MAV_4827|M.avium_104 ---------------------------------------GHVPTPGAGGS TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGP Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGP MSMEG_0868|M.smegmatis_MC2_155 GGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANP Rv1396c|M.tuberculosis_H37Rv GGTG---------------------------------------------- Mb1431c|M.bovis_AF2122/97 GGTG---------------------------------------------- MUL_1145|M.ulcerans_Agy99 GGTGGYNQAFGAVSGVGGAGGAGGQWYGNGGDGGTSWGGAAAGAGGDAGL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M GGAG---------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TGVG---------------------------------------------- MAV_4827|M.avium_104 GGSGGG-------------------------------------------- TH_3810|M.thermoresistible__bu --------------------REGIMPSSRAASARAGAACASSTSRSRRSF Mflv_5091|M.gilvum_PYR-GCK GGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGK Mvan_1264|M.vanbaalenii_PYR-1 GGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGK MSMEG_0868|M.smegmatis_MC2_155 GSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGK Rv1396c|M.tuberculosis_H37Rv -------------------GRGGAAG-LIGDAGTGG------TGGKGGTA Mb1431c|M.bovis_AF2122/97 -------------------GRGGAAG-LIGDAGTGG------TGGKGGTA MUL_1145|M.ulcerans_Agy99 IDNGGDGDSAGVLRQNGIGGHGGAGGSLFGDGGDGGSAGFQSTAGDGGNA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M -------------------GAAGNGGLLLGSGSRGGDGGDGGNGGEGRGG MAB_4284c|M.abscessus_ATCC_199 ---------------VGSHVGGGISESLGGSGSVGGSTAVGGGAHTGVGG MAV_4827|M.avium_104 --------------HVPTPGAGGSGGSGGGHVPTPGTGGPGGTGGSGGGH TH_3810|M.thermoresistible__bu CCSRA--------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GAQGATGAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG Mvan_1264|M.vanbaalenii_PYR-1 GAQGATGAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG MSMEG_0868|M.smegmatis_MC2_155 GGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAG Rv1396c|M.tuberculosis_H37Rv GEDGTGGNG--------------------------------------GTG Mb1431c|M.bovis_AF2122/97 GEDGTGGNG--------------------------------------GTG MUL_1145|M.ulcerans_Agy99 GLVGNGGNGGWAIYNSFAGDDGSGGTAIGNGGDGGANIVSSGFILGAGGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M FSVPQHGVGG-----------------------------------QGGTG MAB_4284c|M.abscessus_ATCC_199 GVNTGVGVGSHVG------------------------------------- MAV_4827|M.avium_104 VPTPGAGTP----------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-- Mvan_1264|M.vanbaalenii_PYR-1 -----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-- MSMEG_0868|M.smegmatis_MC2_155 GFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSK Rv1396c|M.tuberculosis_H37Rv GN--------------GGAAV-LIGNGGGG-------------------- Mb1431c|M.bovis_AF2122/97 GN--------------GGAAV-LIGNGGGG-------------------- MUL_1145|M.ulcerans_Agy99 GN--------------GGNAVGLIGNGGAGGTGADGFSTALGSDGGNGGT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M GN--------------GSDGGWLYGDGGAG-------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------GGISESLGGSGSVGG------------------- MAV_4827|M.avium_104 ----------------GGSGGGHLPFPGAG-------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEG Mvan_1264|M.vanbaalenii_PYR-1 ------AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEG MSMEG_0868|M.smegmatis_MC2_155 IANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTG Rv1396c|M.tuberculosis_H37Rv --------GAGGNGG-------AGNDGTP--------------------- Mb1431c|M.bovis_AF2122/97 --------GAGGNGG-------AGNDGTP--------------------- MUL_1145|M.ulcerans_Agy99 GAWLLGNGGAGGSGGSTAGVHPAGDGGNSGM------------------S MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M --------GAGGNGG-------FGGSGVQN-------------------- MAB_4284c|M.abscessus_ATCC_199 ------STAVGGGAHTSAINDALGGSGSVGG------------------S MAV_4827|M.avium_104 -------STPGGSGGGHLPTPGAGTPGG---------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGS Mvan_1264|M.vanbaalenii_PYR-1 GAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGS MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGA Rv1396c|M.tuberculosis_H37Rv ---GNGGGGG------------VGGTGG--TLFGQPGQ--PGPPGQPGPA Mb1431c|M.bovis_AF2122/97 ---GNGGGGG------------VGGTGG--TLFGQPGQ--PGPPGQPGPA MUL_1145|M.ulcerans_Agy99 ALIGNGGAGGSAGVSPTGVFPSNGGSGGNAQLIGDGGDGGRGDSGGTGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MMAR_4224|M.marinum_M ------GAGG------------DAGSGGDSRLIGDGGAAGAGGTGAPPGA MAB_4284c|M.abscessus_ATCC_199 TAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQG MAV_4827|M.avium_104 ---GLGGFGGG----------HAPAPGGGLGGGGGHAPAPGGGLGGFGGG TH_3810|M.thermoresistible__bu -------------------- Mflv_5091|M.gilvum_PYR-GCK GGSGGSGGAAGDSDD----- Mvan_1264|M.vanbaalenii_PYR-1 GGAGGSGGAAGDSD------ MSMEG_0868|M.smegmatis_MC2_155 DGTPGTAGTTGANNP----- Rv1396c|M.tuberculosis_H37Rv -------------------- Mb1431c|M.bovis_AF2122/97 -------------------- MUL_1145|M.ulcerans_Agy99 GGTGGSLAGHDGSDGD---- MLBr_01183|M.leprae_Br4923 -------------------- MMAR_4224|M.marinum_M DGHSGADGLLSAALGA---- MAB_4284c|M.abscessus_ATCC_199 HAQGHASETAHTTLPGAEHH MAV_4827|M.avium_104 HSGGGLGGLGGGHK------