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SFVVAAPEMVQAAASDIASIGSTINMANVAATAPTTAVLAAGADEVSAVIAALFAAHGQAYQTLSAQAAQ FHDQFVAAMTSAAGAYSGAEAANVSPLQSLLDAANGETMAMLGRPLIGNGADGAPGQAGADGGLLFGNGG NGGSGLAGQAGGVGGAAGLIGNGGNGGAGGAGSNGLAGGSGGAGGWLIGNGGNGGVGGIGSAAVGNGGSG GAGGAAVGLFGNGGIGGAGGGAEGLNGGAGGVGGIGGKLYGDGGAGGIGGMGAADPSAAGGAGGAGGSAV GWFGDGGAGGAGGPVVPTAALGGLGGAGGAGGNGGQLWGDGGAGGLGAFGQHGGGAGGAGGNAGMVGNGG DGGTALGLAHGGDGGTGGTLIGNGGAGGGATMSDAGDGGDAVGLIGSGGAGGIGGAALAGGTGGTGGDGG HGAKLLGNGGAGGAGGAAGGGLGNGGNGGNGGEAALIGNGGAGGDAGTSGSSRNFGDGGNGGDAQLIGNG GNGGRGGVNGTGGTGGNGGTVAGANGTDGP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2709 | - | - | 100% (521) | PE-PGRS family protein, PE_PGRS34_1 |
M. marinum M | MMAR_0299 | - | e-155 | 56.52% (575) | PE-PGRS family protein, PE_PGRS1 |
M. marinum M | MMAR_4224 | - | e-152 | 53.52% (596) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0545 | PE_PGRS6a | 1e-157 | 55.12% (586) | hypothetical protein Mb0545 |
M. gilvum PYR-GCK | Mflv_5091 | - | 2e-92 | 48.02% (454) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1840c | PE_PGRS34 | 1e-173 | 61.75% (536) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 8e-12 | 32.61% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 2e-45 | 34.19% (468) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 5e-22 | 39.04% (187) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 3e-80 | 43.14% (503) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 2e-37 | 39.53% (301) | PUTATIVE - |
M. ulcerans Agy99 | MUL_3056 | - | 1e-163 | 56.23% (546) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 2e-88 | 43.64% (550) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Rv1840c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_3056|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2709|M.marinum_M -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1840c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_3056|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2709|M.marinum_M -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1840c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_3056|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2709|M.marinum_M -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1840c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_3056|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2709|M.marinum_M -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1840c|M.tuberculosis_H37Rv ------------------------------------MSFVVAAPEVVVAA MUL_3056|M.ulcerans_Agy99 ------------------------------------MSFVVAAPDAVTAA MMAR_2709|M.marinum_M ------------------------------------MSFVVAAPEMVQAA Mb0545|M.bovis_AF2122/97 ------------------------------------MSNLLVTPELVAAA Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -----------------------------------MPLFLNAEPQALTAA MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MAV_4827|M.avium_104 --------------------------------MNIVLGVSMAPSSIQMVV Rv1840c|M.tuberculosis_H37Rv ASDLAGIGSAIGAANAAAAVPTMGVLAAGADEVSAAVADLFGAHAQAYQA MUL_3056|M.ulcerans_Agy99 VQDLASIGSAINVANAAAATPTTGALAAAADEVSAAVAALFDGHAQAYQL MMAR_2709|M.marinum_M ASDIASIGSTINMANVAATAPTTAVLAAGADEVSAVIAALFAAHGQAYQT Mb0545|M.bovis_AF2122/97 AADLAGIGSAIGAANAAAGAPTMALLAAGADEVSAAVAAVFSSYAQQYQA Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MLBr_01183|M.leprae_Br4923 ANTLEGLSAATVASNAAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQA MAB_4284c|M.abscessus_ATCC_199 VEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVN MAV_4827|M.avium_104 LEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQ Rv1840c|M.tuberculosis_H37Rv LSAQAALFHEQFVHAMTAGAGAY---AGAEAADA----AALDVLNGPFQA MUL_3056|M.ulcerans_Agy99 IGAQAAEFHERFVRAMAAGAASY---ATAEAANASPLQAALDAVNAPAQA MMAR_2709|M.marinum_M LSAQAAQFHDQFVAAMTSAAGAY---SGAEAANVSPLQSLLDAANGETMA Mb0545|M.bovis_AF2122/97 LSAAAAAFHDQFVRALAAGAGAY---AGAEAANVE--QQLLNAINAPTLA Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGN---GGVGVVGATGAVG--APGVAGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGN---GGVGIAGATGAVG--APGVAGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGA---GGVGADGTSAHVDGGTGGTGGTGG TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGD---GGLG-------------GNGGHGG MLBr_01183|M.leprae_Br4923 HASQGATNHQDLIQSLLTSSSAY---AGTET--------------ANHDS MAB_4284c|M.abscessus_ATCC_199 TGNPIHDLSGNLQNYYAAQPDGP---SILSPSLLSPRDNDFLSHNDTDFA MAV_4827|M.avium_104 LSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMG . . Rv1840c|M.tuberculosis_H37Rv LFGRPLIGDGANGAP--GQPGGPGGLLYGNGGNGGNGG------------ MUL_3056|M.ulcerans_Agy99 LLGRPLIGDGADGAP--GQPGGAGGLLYGNGGSGGNGG------------ MMAR_2709|M.marinum_M MLGRPLIGNGADGAP--GQAGADGGLLFGNGGNGGSGL------------ Mb0545|M.bovis_AF2122/97 LLGRPLIGNGADGAAGTGQAGGAGGLLYGNGGNGGSGA------------ Mflv_5091|M.gilvum_PYR-GCK ATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------------ Mvan_1264|M.vanbaalenii_PYR-1 ATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------------ MSMEG_0868|M.smegmatis_MC2_155 GTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGP TH_3810|M.thermoresistible__bu GTGIIS--------------------LLSLAGNGGNGG------------ MLBr_01183|M.leprae_Br4923 L------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVA MAV_4827|M.avium_104 YERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMV Rv1840c|M.tuberculosis_H37Rv --IGQPGGAGGDAGLIGNGG------------------------------ MUL_3056|M.ulcerans_Agy99 --IGQAGGAGGDAGLIGNGG------------------------------ MMAR_2709|M.marinum_M --AGQAGGVGGAAGLIGNGG------------------------------ Mb0545|M.bovis_AF2122/97 --AGQAGGAGGAAGLIGHGG------------------------------ Mflv_5091|M.gilvum_PYR-GCK --AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG------------- Mvan_1264|M.vanbaalenii_PYR-1 --AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG------------- MSMEG_0868|M.smegmatis_MC2_155 NVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTV TH_3810|M.thermoresistible__bu ---NGYRTTDNNALDGGHGG------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGSNSGPIASGQGSTAVNG------------------------------ MAV_4827|M.avium_104 AGLEKLESLPGGLLLVGSGVDVAP-------------------------- Rv1840c|M.tuberculosis_H37Rv ---------------------------------------------NGGIG MUL_3056|M.ulcerans_Agy99 ---------------------------------------------SGGIG MMAR_2709|M.marinum_M ---------------------------------------------NGGAG Mb0545|M.bovis_AF2122/97 ---------------------------------------------TGGVG Mflv_5091|M.gilvum_PYR-GCK ---AVGAAGAAG------TVGTAGATGGTG---------------TGANG Mvan_1264|M.vanbaalenii_PYR-1 ---AIGTAGVAG------AAGTAGATGGTG---------------VGGNG MSMEG_0868|M.smegmatis_MC2_155 DGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDG TH_3810|M.thermoresistible__bu ---------------------------------------------NGGNV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------DVRDSNIINADHGSNV MAV_4827|M.avium_104 ----------------------------------LKQVLQTTTFLDVSVA Rv1840c|M.tuberculosis_H37Rv GPGATGLAGGAGGVG------------GLLFGDGGNGGAGGLGTGPVGAT MUL_3056|M.ulcerans_Agy99 GPDSTGLPGGAGGAG------------GWLLGDGGNGGIGGAGTG-IGGA MMAR_2709|M.marinum_M GAGSNGLAGGSGGAG------------GWLIGNGGNGGVGGIGSAAVGNG Mb0545|M.bovis_AF2122/97 G---TGAAGGAGGTG------------GWLFGNGGAGGTGGAVTG-VSTT Mflv_5091|M.gilvum_PYR-GCK GAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVG Mvan_1264|M.vanbaalenii_PYR-1 GAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIG MSMEG_0868|M.smegmatis_MC2_155 GHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMG TH_3810|M.thermoresistible__bu GFFSLFNLGG--------------------AGGWGGSGVDG--------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDR MAV_4827|M.avium_104 EEPETALARGAALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYV Rv1840c|M.tuberculosis_H37Rv GGIGGPGGAAVGLFGHGGAGGAGGLGKAGFAGGAG--------------- MUL_3056|M.ulcerans_Agy99 GGSGGQGGAAAWLFGSGGTGGAGGFGNSG-TGGPG--------------- MMAR_2709|M.marinum_M G-SGGAGGAAVGLFGNGGIGGAGG-GAEGLNGGAG--------------- Mb0545|M.bovis_AF2122/97 GGPGGHGGDAG-LYGFGGAGGAGGFGQSGAAGGAG--------------- Mflv_5091|M.gilvum_PYR-GCK GQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG-------- Mvan_1264|M.vanbaalenii_PYR-1 GQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG-------- MSMEG_0868|M.smegmatis_MC2_155 EIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKAS TH_3810|M.thermoresistible__bu ------------VDVVGGNP------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 STNIGSGNTTNTEIGSHNQANIGTSTSAGGSAAVG--------------- MAV_4827|M.avium_104 PVDPEPGDDELAYSAVGEEDAESPTVVIEKLFLPE--------------- Rv1840c|M.tuberculosis_H37Rv -----------GTGGTGG---------------------------LLYGN MUL_3056|M.ulcerans_Agy99 -----------GAGGTGG---------------------------LLIGN MMAR_2709|M.marinum_M -----------GVGGIGG---------------------------KLYGD Mb0545|M.bovis_AF2122/97 -----------GAGGAGG---------------------------WLYGD Mflv_5091|M.gilvum_PYR-GCK -----LQGGKGGDGGAGGKGGDADSMGS------------------AGAT Mvan_1264|M.vanbaalenii_PYR-1 -----LQGGQGGDGGTGGTGGDATSMGE------------------AGAT MSMEG_0868|M.smegmatis_MC2_155 GTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASAN TH_3810|M.thermoresistible__bu ------------DGGTPG------------------------------AH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------GNAGLAGNAG-------------------------LAGN MAV_4827|M.avium_104 ------------DSEPRRRP-------------------------VLLVG Rv1840c|M.tuberculosis_H37Rv GGNGGNVPSGAAD------------------------------------- MUL_3056|M.ulcerans_Agy99 GGNGGYDIQGGAF------------------------------------- MMAR_2709|M.marinum_M GGAGGIGGMGAADPSA---------------------------------- Mb0545|M.bovis_AF2122/97 GGDGGAGGNGGNESGTG--------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGKGGNGGNGGRGGLFG---------------KGGNAGNGAD-------- Mvan_1264|M.vanbaalenii_PYR-1 GGKGGNGGNGGRGSLFG---------------RGGNAGNGGN-------- MSMEG_0868|M.smegmatis_MC2_155 GAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDP TH_3810|M.thermoresistible__bu GESHTPGVYTDRQ------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAGLAG--------------------------------- MAV_4827|M.avium_104 SGLAVVGISAVLALEIALAIG----------------------------- Rv1840c|M.tuberculosis_H37Rv --------------------GGAGGDAR-LIGNGGDGGS----------- MUL_3056|M.ulcerans_Agy99 --------------------GGDGGNAR-LIGNGGDGGV----------- MMAR_2709|M.marinum_M ----------------AGGAGGAGGSAVGWFGDGGAGGAG---------- Mb0545|M.bovis_AF2122/97 -------------VSGVGGVGGAGGAGGLLFGNGGDGGVG---------- Mflv_5091|M.gilvum_PYR-GCK --------------GGTGGAGGAGGTGG-TGGAGGTGG------------ Mvan_1264|M.vanbaalenii_PYR-1 --------------GGTGGNGGNGGTGG-TGGNGGTGG------------ MSMEG_0868|M.smegmatis_MC2_155 NGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHS TH_3810|M.thermoresistible__bu ------------------GEDGEDGTGTGIGGRGGNGG------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------NAGLAGNAGLAGNAGLAGNAGLAGNAG---------- MAV_4827|M.avium_104 --------------IRTTGTVALQPTPNQHLIVPTEQAPAP--------- Rv1840c|M.tuberculosis_H37Rv -----------------VGAAPTGIGNGGNGGNGGWLYGDGGSGGSTLQG MUL_3056|M.ulcerans_Agy99 -----------------EAGGPG--TTGGDGGNGGWLLGNGGNGAADGGG MMAR_2709|M.marinum_M ---------GPV---VPTAALGGLGGAGGAGGNGGQLWGDGGAGGLGAFG Mb0545|M.bovis_AF2122/97 ---------GDGGDGSSTQDSGGDGGAGGAGGAGGWLLGNGGAGGAGGAA Mflv_5091|M.gilvum_PYR-GCK -----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 -----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTG MSMEG_0868|M.smegmatis_MC2_155 TGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDG TH_3810|M.thermoresistible__bu ----SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSHGGNG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----LAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG MAV_4827|M.avium_104 ------PPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAPPLP Rv1840c|M.tuberculosis_H37Rv FS-----------------------DG--------GTGGNAGMFGDGGNG MUL_3056|M.ulcerans_Agy99 AGSAAGAGGNAGLIGNGGHGGLEHIDGTGGAGSIAGAGGDAGLFGSGGNG MMAR_2709|M.marinum_M QHG----------------------GGAG------GAGGNAGMVGNGGDG Mb0545|M.bovis_AF2122/97 SIKVAT-------------------GGLG------GDGGDAGLFGFGGDG Mflv_5091|M.gilvum_PYR-GCK GKGGTG--------------GTGGAGGTG---------GDGGTGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 GKGGTG--------------GTGGDGGTG---------GTGGTGGTGGTG MSMEG_0868|M.smegmatis_MC2_155 GRGGDG--------------ALGGNGGTGG-----VGLGNGGKGGNGGNG TH_3810|M.thermoresistible__bu GHGGRG--------------GFLGIGGSG------------GWGGHGGNG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NAGLAG--------------NAGLAGNAG-------LAGNAGLAGNAAVA MAV_4827|M.avium_104 EAPPIP--------------AAPPVVPVPVVVPPVPVPVPVRIPVPDPVS Rv1840c|M.tuberculosis_H37Rv G---------FSFFDGNGGDGGTG-----------GTLIGNGGDG----- MUL_3056|M.ulcerans_Agy99 G---------FNGYQGVGGAGGAG-----------GKLFGDGGDG----- MMAR_2709|M.marinum_M G---------TALGLAHGGDGGTG-----------GTLIGNGGAG----- Mb0545|M.bovis_AF2122/97 GWGGRGVDARFGAAGGAAGAGGAG-----------GWLYGDGGAGGVGGV Mflv_5091|M.gilvum_PYR-GCK GTG---------GTGGTGGTGGAG-----------DGTGGTGGTGG---- Mvan_1264|M.vanbaalenii_PYR-1 GTG---------GTGGTGGTGGAG-----------DGLGGTGGTGG---- MSMEG_0868|M.smegmatis_MC2_155 GNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDA TH_3810|M.thermoresistible__bu GD-----------TDADGGNGGDG---------------GNGGSAG---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GNAAVAGNAAVAGNAAVGGVLNTG---------VSGAIGGSSHVGG--AI MAV_4827|M.avium_104 PPQLLAPPRLSVPQPVQPPVRVPQ----------PPSPPQVGGTVPQSPP Rv1840c|M.tuberculosis_H37Rv GNSVQTDGFLR-----------------GHGGDGGNAVGLIGNGGAG--- MUL_3056|M.ulcerans_Agy99 GDCAESNGGI------------------GSGGRGGSAVGLIGNGGAG--- MMAR_2709|M.marinum_M GGATMS-----------------------DAGDGGDAVGLIGSGGAG--- Mb0545|M.bovis_AF2122/97 GGAVFSLSSGDG----------------GAGGAGGGGGWLFGNGGDG--- Mflv_5091|M.gilvum_PYR-GCK TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGGGTG--- Mvan_1264|M.vanbaalenii_PYR-1 TGGFGGQGGQGG-----------------TGGTGGQGG-LGGVGGTG--- MSMEG_0868|M.smegmatis_MC2_155 DGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAA TH_3810|M.thermoresistible__bu -----------------------------RGGTGGLRGVFGINGGNG--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NESLGGSGSVGG------------STAVGGGAHTGVGGGVSTGVGVG--- MAV_4827|M.avium_104 QHQTPPGEGTPP----------------KPDGPGNYGGGHVPTPGAG--- Rv1840c|M.tuberculosis_H37Rv ---------------------GAGSAGTGVFAPGGGSGGNG--------- MUL_3056|M.ulcerans_Agy99 ---------------------GVG--GVGRNANAGGSGGSG--------- MMAR_2709|M.marinum_M ---------------------GIG--GAALAGGTGGTGGDG--------- Mb0545|M.bovis_AF2122/97 ---------------------GAGGGGGGRFGSGSGAGGDGAVG------ Mflv_5091|M.gilvum_PYR-GCK --------------------GQGGTGGTGGQGGTGGTGGTGGTG------ Mvan_1264|M.vanbaalenii_PYR-1 --------------------GTGGTGGTGGQGGTGGTGGTGGTG------ MSMEG_0868|M.smegmatis_MC2_155 TIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVAS TH_3810|M.thermoresistible__bu ---------------------RAGLGGRGXXXXGGGVGAAVRSG------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------SHVGGGISESLGGSGSVGGSTAVG------ MAV_4827|M.avium_104 ----------------------GSGGSGGGHVPTPGAGGSGGSG------ Rv1840c|M.tuberculosis_H37Rv -------GNGALLVGNGGAGGSGGPTQIPSVAV-PVTGAGGTGGNG---- MUL_3056|M.ulcerans_Agy99 -------GNAAWLFGDGGAGGSGGSSD---------TAASGAGGNG---- MMAR_2709|M.marinum_M -------GHGAKLLGNGGAGGAGGAAG-------GGLGNGGNGGNG---- Mb0545|M.bovis_AF2122/97 -----GAGGAGAWFGNGGAGGVGGGGGRGTTAIGGDGGAGGAGGAGG--- Mflv_5091|M.gilvum_PYR-GCK --GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QA Mvan_1264|M.vanbaalenii_PYR-1 --GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QA MSMEG_0868|M.smegmatis_MC2_155 GIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKAT TH_3810|M.thermoresistible__bu ---------NGVFSGGGGTPSAGFGVPTTIQFPAGSCTSRAVSREG---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------GGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGG---- MAV_4827|M.avium_104 -------GGHVPTPGTGGPGGTGGSGGGHVPTPGAGTPGGSGGGHLP--- Rv1840c|M.tuberculosis_H37Rv -----------------GTAGLIGNGGNGGAAGVSGDG-TPGTGGNGG-- MUL_3056|M.ulcerans_Agy99 -----------------GTAALIGNGGAGGDAGVSFAG-MAGPGGNGG-- MMAR_2709|M.marinum_M -----------------GEAALIGNGGAGGDAGTSGSSRNFGDGGNGG-- Mb0545|M.bovis_AF2122/97 --------------WLYGDGGAGGAGGGGGRGGTGNDGGDGGDGGRGG-- Mflv_5091|M.gilvum_PYR-GCK GTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG--- Mvan_1264|M.vanbaalenii_PYR-1 GVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG--- MSMEG_0868|M.smegmatis_MC2_155 GTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNA TH_3810|M.thermoresistible__bu --------------------IMPSSRAASARAG----------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------STAVGGGAHTGVGGGVNTGVGVGSHVGGG-- MAV_4827|M.avium_104 ---------------FPGAGSTPGGSGGGHLPTPGAGTPGGGLGGFGGG- Rv1840c|M.tuberculosis_H37Rv ----------YAQLIGDGGDGGPGDSGGPG-------------------- MUL_3056|M.ulcerans_Agy99 ----------DARLIGDGGDGG---RGAPG-------------------- MMAR_2709|M.marinum_M ----------DAQLIGNGGNGGRGGVNGTG-------------------- Mb0545|M.bovis_AF2122/97 ----------DAQLLGNGGDGGAGGAGGPAGFGAS--------PGAGAAG Mflv_5091|M.gilvum_PYR-GCK ---AQGATG-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQ Mvan_1264|M.vanbaalenii_PYR-1 ---AQGATG-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQ MSMEG_0868|M.smegmatis_MC2_155 LVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDST TH_3810|M.thermoresistible__bu ----------AACASSTSRSRRSFCCSRA--------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------ISESLGGSGSVGGSTAVGGGAHTSAIN----------DALG MAV_4827|M.avium_104 ----------HAPAPGGGLGGGGGHAPAPGGGLGG--------------F Rv1840c|M.tuberculosis_H37Rv GSGGTGGTLAGQNGSPGG-------------------------------- MUL_3056|M.ulcerans_Agy99 GAGGMGGSLFGQDGSNGA-------------------------------- MMAR_2709|M.marinum_M GTGGNGGTVAGANGTDGP-------------------------------- Mb0545|M.bovis_AF2122/97 GGGGAGGSLFGSPGTTGPHG------------------------------ Mflv_5091|M.gilvum_PYR-GCK GSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAGS Mvan_1264|M.vanbaalenii_PYR-1 GSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPGS MSMEG_0868|M.smegmatis_MC2_155 AISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGV TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GSGSVGGSTAVGGGAHTSAINESMN------------------------- MAV_4827|M.avium_104 GGGHSGGGLGGLGGGHK--------------------------------- Rv1840c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_3056|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2709|M.marinum_M -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGSG-INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE----- Mvan_1264|M.vanbaalenii_PYR-1 EAVD-INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE----- MSMEG_0868|M.smegmatis_MC2_155 NGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------SSINASH MAV_4827|M.avium_104 -------------------------------------------------- Rv1840c|M.tuberculosis_H37Rv ------------------------------------------------- MUL_3056|M.ulcerans_Agy99 ------------------------------------------------- MMAR_2709|M.marinum_M ------------------------------------------------- Mb0545|M.bovis_AF2122/97 ------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ---GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 ---GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 NGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu ------------------------------------------------- MLBr_01183|M.leprae_Br4923 ------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH--- MAV_4827|M.avium_104 -------------------------------------------------