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VSGGVPAGLALDNWLSSPYSHWAFQHVEDFMPTTVIARGTEPVVTLPADNAPIADIGLTSTDGIATTVGA VMAATATDGWAVAHRGALVAEQYLDGLGPRTRHLLFSVSKSLVAAVVGALHGAGAIELDAPVTAYVPALA DCGYAGATVRHLLDMRSGVAFSENYDDPAAEIHVREQVIGWAPKRGPDLPATLRDYLLTLRRKSAHGGPF EYRSCETDVLGWICEAAAGQPMPELMSELLWSRIGAQCDATIALDVAGAAGTGIFDGGISACLTDMIRFG SLYLRDGVSLAGQQVVPAAWIADTFDGGPDSRQAFAASPDDNPMPGGMYRNQVWFPYPGSNVALCVGMCG QLIYVNRAAEVVAAKLSTQPHSHEPHMLDTLRAFDAVAHELSGIRSSSTNDPQRPSPPAQEASPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1723 | - | - | 100% (415) | PROBABLE HYDROLASE |
| M. tuberculosis H37Rv | Rv1922 | - | 2e-07 | 27.38% (252) | lipoprotein |
| M. tuberculosis H37Rv | Rv1730c | - | 3e-06 | 23.79% (290) | penicillin-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1752 | - | 0.0 | 100.00% (415) | hydrolase |
| M. gilvum PYR-GCK | Mflv_0495 | - | 1e-06 | 28.12% (224) | beta-lactamase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2179 | - | 6e-08 | 30.50% (200) | Beta-lactamase/esterase |
| M. marinum M | MMAR_3387 | - | 0.0 | 83.67% (398) | hypothetical protein MMAR_3387 |
| M. avium 104 | MAV_2718 | - | 0.0 | 78.61% (388) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_4455 | - | 4e-07 | 28.57% (147) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 7e-06 | 25.87% (143) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_2951 | lipD | 8e-05 | 33.33% (84) | lipase LipD |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4455|M.smegmatis_MC2_155 -------MRIVRALVAAALVAAVSAGCSTSPDAAEEAFATTEPPALKTID
TH_3520|M.thermoresistible__bu -------MRAVRTLAALLLAVFAVSAGPS---------AAGQPPDLA---
Rv1723|M.tuberculosis_H37Rv MSGGVPAGLALDNWLSSPYSHWAFQHVEDFMPTTVIARGTEPVVTLPADN
Mb1752|M.bovis_AF2122/97 MSGGVPAGLALDNWLSSPYSHWAFQHVEDFMPTTVIARGTEPVVTLPADN
MMAR_3387|M.marinum_M MSGGVPAGLSLGNWLSSPYSHWAFQHVEDFMPTALISRGTNPAVALPAAG
MAV_2718|M.avium_104 MN--APAGISLDNWLSPPYARWSFQHVEDFVPTAVIARGTGPVAAIPAAP
Mflv_0495|M.gilvum_PYR-GCK MTRSSTRLRRLGAAGAVVLALGACGDRPEPPGTSAVRPPATPTRVLPSPP
MAB_2179|M.abscessus_ATCC_1997 -------MGSDSTLAERLDEVFGAA-------------------------
MUL_2951|M.ulcerans_Agy99 -------MAQPSVPTTDDGLPSGVAGACDSRFSGVVRAFAG---------
MSMEG_4455|M.smegmatis_MC2_155 PAHLQSI-----------VADTAKSLDVPGALVLLQTP-QGRFAAGVGTT
TH_3520|M.thermoresistible__bu -AALDRA-----------IELRLDQMGVPGAIVSLSIPGKIEYTRAFGVG
Rv1723|M.tuberculosis_H37Rv APIADIG-----------LTSTDGIATTVGAVMAATATDGWAVAHRGALV
Mb1752|M.bovis_AF2122/97 APIADIG-----------LTSTDGIATTVGAVMAATATDGWAVAHRGALV
MMAR_3387|M.marinum_M APVADIE-----------LTNTEGAPTTVGAVMAGTVTDGWAVAHRGALV
MAV_2718|M.avium_104 SELAEIR-----------VAVTDGTASTVGAVMAGTATDGWAVAHRGAMI
Mflv_0495|M.gilvum_PYR-GCK PPVPEVTPTGDFSAVARLVEDAIAARRLPGAVVQVGHAGKVVFRRAFGVR
MAB_2179|M.abscessus_ATCC_1997 ----------------------LRERRVVGAVAVVARDGQVQYRRAHGLA
MUL_2951|M.ulcerans_Agy99 ---------------------LYPGRKFGGGALSVYTEGRQVVDVWTGWA
*. .
MSMEG_4455|M.smegmatis_MC2_155 ELGT----------QTPPRPDTHFRIASNTKTMT-AAVIMLLAQDGKLSL
TH_3520|M.thermoresistible__bu DTAT----------GTPMLVDNHHRIGSVTKTFI-GTAILQLADQGRIRL
Rv1723|M.tuberculosis_H37Rv AEQY----------LDGLGPRTRHLLFSVSKSLV-AAVVGALHGAGAIEL
Mb1752|M.bovis_AF2122/97 AEQY----------LDGLGPRTRHLLFSVSKSLV-AAVVGALHGAGAIEL
MMAR_3387|M.marinum_M AEEY----------LGGLRPQTRHLLFSVSKSLV-AAVVGALSGAGAIDV
MAV_2718|M.avium_104 AEHY----------LEGMRRQTRHLLFSVSKSLV-AAVVGALHGAGAIEL
Mflv_0495|M.gilvum_PYR-GCK KLESEPGLDGAPAPAEPMTEDTVFDIASLTKSLATATAVMQLHEQGRVRI
MAB_2179|M.abscessus_ATCC_1997 DREG----------SLPMREDTLFRLASVTKPIV-TVAVLRLVGDELIRL
MUL_2951|M.ulcerans_Agy99 DRNG----------EVPWTADTGAMVFSATKGLA-ATVIHRLVDRGLLDY
. : * :* : ..: * :
MSMEG_4455|M.smegmatis_MC2_155 DDPVAKYVPGVPNA------DAITLIDLLRMRSGLYC--YTNDSEFAATL
TH_3520|M.thermoresistible__bu SDPISRYVEGVPSG------DVITLDMLARMRSGLAD--YTETDEFVERL
Rv1723|M.tuberculosis_H37Rv DAPVTAYVPALADCG----YAGATVRHLLDMRSGVAF--SENYDDPAAEI
Mb1752|M.bovis_AF2122/97 DAPVTAYVPALADCG----YAGATVRHLLDMRSGVAF--SENYDDPAAEI
MMAR_3387|M.marinum_M DAPVTTYVPALANCG----YAGAKVRHLLDMRSGVGF--SENYDDPAAEI
MAV_2718|M.avium_104 DAPVTKYIPALANCG----YAGATVRHLLDMRSGVAF--SENYDDPAAQI
Mflv_0495|M.gilvum_PYR-GCK DEPVQTYLPGFNPAGDP-RRAAVTVRMLLTHTSGIAG--DLSLDGPWGLA
MAB_2179|M.abscessus_ATCC_1997 DDPVTRWLPDFTPRLPDGSTPALTIHHLLTHTAGLSYGLLEEPDSPFHAL
MUL_2951|M.ulcerans_Agy99 DAPVADYWPEFGVKG----KSAITVSDLLRHRSGLSHLKGVGKKEILDHL
. *: : . .: * :*: .
MSMEG_4455|M.smegmatis_MC2_155 DSDP--------AKTWTPQEVLDIAFDHPSTVAPDTAYEYCNTNYALLGV
TH_3520|M.thermoresistible__bu YRESPSG---PDAFAVTPRELVESAFARPLNFAPGSEFEYSNTNTVLLGM
Rv1723|M.tuberculosis_H37Rv HVREQVIGWAPKRGPDLPATLRDYLLTLRRKSAHGGPFEYRSCETDVLGW
Mb1752|M.bovis_AF2122/97 HVREQVIGWAPKRGPDLPATLRDYLLTLRRKSAHGGPFEYRSCETDVLGW
MMAR_3387|M.marinum_M HVREQVIGWAPKHNPDVPATLRDYLLTLRQKSAHGGPFEYRSCETDVLGW
MAV_2718|M.avium_104 HLLDQAVGWAPNHRPDAPATLRDFLLTLRQKSVHGGPFEYRSCETDVLGW
Mflv_0495|M.gilvum_PYR-GCK GPDK--------------ADGVRRALGAWVVSDPGEGFHYSDINFIILGA
MAB_2179|M.abscessus_ATCC_1997 GISDG-----IDVVDFDLRENLRRLALAPLQFAPGSAWRYS-LALDVLGA
MUL_2951|M.ulcerans_Agy99 RMEEK-----------LAAAPLDRTHGKMAYHAVTYGWLLSGLARAVTGK
: : *
MSMEG_4455|M.smegmatis_MC2_155 VAEQVGGAPLAEQFQQR---LFGPLGMRNTLLPSP------------AEA
TH_3520|M.thermoresistible__bu VVERVSGVPLARYLQDN---IFGPVGLTQTSYP---------------AD
Rv1723|M.tuberculosis_H37Rv ICEAAAGQPMPELMSEL---LWSRIGAQCDATI----------------A
Mb1752|M.bovis_AF2122/97 ICEAAAGQPMPELMSEL---LWSRIGAQCDATI----------------A
MMAR_3387|M.marinum_M ICEVAGGQPMPELMSHL---LWSRIGAQCDASI----------------A
MAV_2718|M.avium_104 ICEVAADQPMPALMSEL---LWSRIGAQRDATI----------------A
Mflv_0495|M.gilvum_PYR-GCK LVEKITGEPEDSYVDRN---VFAPLKMSETRYLPVTKVCGPHRVRGTAIA
MAB_2179|M.abscessus_ATCC_1997 VVENATGLPLDLAVEKL---VTSPLGMHESGFVAR-------------DL
MUL_2951|M.ulcerans_Agy99 GMRDLFREELARPLDTDGLHLGRPPGDAPTTAAQTLLP----QSKIPTPL
. .. :
MSMEG_4455|M.smegmatis_MC2_155 SEIPAPYSHGYMYGETLYAMVDETYPAAITDAARAGTLKP--------ND
TH_3520|M.thermoresistible__bu GRLPAPYTHGYNQGP----------DGAIVDTT-----------------
Rv1723|M.tuberculosis_H37Rv LDVAGAAGTGIFDGG---------ISACLTDMIRFGSLYL--------RD
Mb1752|M.bovis_AF2122/97 LDVAGAAGTGIFDGG---------ISACLTDMIRFGSLYL--------RD
MMAR_3387|M.marinum_M LDTAGPAGTGIFDGG---------INACLTDMIRFGSLFL--------RD
MAV_2718|M.avium_104 VD---PAGTGFFDGG---------ISACLTDMIRFGSLFL--------RE
Mflv_0495|M.gilvum_PYR-GCK ADPHGQAVDNCPDGTWNIDLLERIAPTALDEDTPGLNPDYGYPLRGTVHD
MAB_2179|M.abscessus_ATCC_1997 TRFAVPYANGEPEPFRIADNVNVPLPQGIGVAVRFGPARV----------
MUL_2951|M.ulcerans_Agy99 LDFIAPKVAGLSFSGLLGAVYFPGILSMLQDDMPFLDGEIPAVNG-VVTA
. :
MSMEG_4455|M.smegmatis_MC2_155 YTHQNSSYATAAGGAISTADDLATWIRALVGGK--VLDSEHQQQFLDSL-
TH_3520|M.thermoresistible__bu --LWNPAWADAAGKIVSNVHDMRTWARALGSGA--LLRPDTHAERIHGG-
Rv1723|M.tuberculosis_H37Rv GVSLAGQQVVPAAWIADTFDGGPDSRQAFAASP--DDNPMPGGMYRNQV-
Mb1752|M.bovis_AF2122/97 GVSLAGQQVVPAAWIADTFDGGPDSRQAFAASP--DDNPMPGGMYRNQV-
MMAR_3387|M.marinum_M GVSLTGQQVVPAAWIADTLDGGTDSRQAFAASP--DDTKMPGGMYRNQV-
MAV_2718|M.avium_104 GVSLTGRRVLPEAWIADTLAGGPDSRRAFAASP--DDNEMPGGMYRNQM-
Mflv_0495|M.gilvum_PYR-GCK PTARRMGGVAGSAGVFTTVHDMGRFAQALLDRV--AGRPSPFPLSQAGAR
MAB_2179|M.abscessus_ATCC_1997 --TRGDAYPSGGAGMYGTADDVLLLLEAIRAGDGFLAEELRTSMRTDHVG
MUL_2951|M.ulcerans_Agy99 RALAKTYAALANDGVIDGMRLLSSDAVSGLTGKAELWPDLNLGLPFTYHQ
:
MSMEG_4455|M.smegmatis_MC2_155 ---LPEDPDNPDGGQSYGYGISFQRFGPEAAMYYHGGEMPGFNSFMGYDP
TH_3520|M.thermoresistible__bu ---SSVVP---------GVDYSFAIFNAQGWLGHNG-DIPGYATVVVYLP
Rv1723|M.tuberculosis_H37Rv ---WFPYPG----------SNVALCVGMCGQLIYVNRAAEVVAAKLSTQP
Mb1752|M.bovis_AF2122/97 ---WFPYPG----------SNVALCVGMCGQLIYVNRAAEVVAAKLSTQP
MMAR_3387|M.marinum_M ---WFPYPG----------SNVALCVGMCGQLIYINRAAQVVGAKLSSRP
MAV_2718|M.avium_104 ---WLPYPG----------DNVLLCLGMCGQMIYVNRAAEMVAAKVSTQP
Mflv_0495|M.gilvum_PYR-GCK MMTTPQQPAPGRDLRGFGWDIDTAHSGPRGSVFPVGSFGHTGFTGVSVWL
MAB_2179|M.abscessus_ATCC_1997 PQAQTRGPGWGFGYG----GAVLADPAAADSPQSAGTIGWGGVYGHSWFV
MUL_2951|M.ulcerans_Agy99 GYQSPPVPGLLGGYGHIGLGGTIGWADPESGS-AFGYVHNRLLTLLLFDI
* . .
MSMEG_4455|M.smegmatis_MC2_155 DNDVALVIWTNLTLSPDNKT--TANAMLPVVLKEIYSDLSF---------
TH_3520|M.thermoresistible__bu ERDATLVVFVNSDVPEPHSAGQIAYVVTEMVTPEHIYELGPQPPQMLDEP
Rv1723|M.tuberculosis_H37Rv HSHEP--HMLDTLRAFDAVAHELSGIRSSSTNDPQRPSPPAQEASPG---
Mb1752|M.bovis_AF2122/97 HSHEP--HMLDTLRAFDAVAHELSGIRSSSTNDPQRPSPPAQEASPG---
MMAR_3387|M.marinum_M ASQDDPQQQANTLRAFDVVARELGGITS----------------------
MAV_2718|M.avium_104 HSHEP--HMLDTLSAFDAIAYRLAGRTD----------------------
Mflv_0495|M.gilvum_PYR-GCK DPESDTYVVILGNVIHQRGGPPITPLSGAVATEAARALHLYGS-------
MAB_2179|M.abscessus_ATCC_1997 DAARGLSVLLLTNTAYEGMTGPLTVEMRDAVYAAD---------------
MUL_2951|M.ulcerans_Agy99 GSFAGLAPLLSSAVSTARREGPLEVPHFGASYRETGQQPLAAGETS----
MSMEG_4455|M.smegmatis_MC2_155 --
TH_3520|M.thermoresistible__bu AA
Rv1723|M.tuberculosis_H37Rv --
Mb1752|M.bovis_AF2122/97 --
MMAR_3387|M.marinum_M --
MAV_2718|M.avium_104 --
Mflv_0495|M.gilvum_PYR-GCK --
MAB_2179|M.abscessus_ATCC_1997 --
MUL_2951|M.ulcerans_Agy99 --