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LRIVRALVAAALVAAVSAGCSTSPDAAEEAFATTEPPALKTIDPAHLQSIVADTAKSLDVPGALVLLQTP QGRFAAGVGTTELGTQTPPRPDTHFRIASNTKTMTAAVIMLLAQDGKLSLDDPVAKYVPGVPNADAITLI DLLRMRSGLYCYTNDSEFAATLDSDPAKTWTPQEVLDIAFDHPSTVAPDTAYEYCNTNYALLGVVAEQVG GAPLAEQFQQRLFGPLGMRNTLLPSPAEASEIPAPYSHGYMYGETLYAMVDETYPAAITDAARAGTLKPN DYTHQNSSYATAAGGAISTADDLATWIRALVGGKVLDSEHQQQFLDSLLPEDPDNPDGGQSYGYGISFQR FGPEAAMYYHGGEMPGFNSFMGYDPDNDVALVIWTNLTLSPDNKTTANAMLPVVLKEIYSDLSF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4455 | - | - | 100% (414) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_1586 | - | 3e-47 | 32.56% (387) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3378 | - | 2e-43 | 33.33% (348) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0405c | lpqK | 2e-22 | 27.02% (359) | lipoprotein LpqK |
| M. gilvum PYR-GCK | Mflv_3749 | - | 2e-14 | 27.52% (258) | beta-lactamase |
| M. tuberculosis H37Rv | Rv0399c | lpqK | 2e-22 | 27.02% (359) | lipoprotein LpqK |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0330 | - | 7e-55 | 36.07% (377) | Beta-lactamase |
| M. marinum M | MMAR_0696 | lpqK | 3e-28 | 26.46% (393) | lipoprotein, LpqK |
| M. avium 104 | MAV_3991 | - | 2e-16 | 31.76% (255) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 2e-50 | 36.43% (398) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 4e-14 | 26.06% (307) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_3027 | - | 8e-53 | 33.57% (420) | Serine-type D-Ala-D-Ala carboxypeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0405c|M.bovis_AF2122/97 --------------MPVLRRLGCSVLALGLLAGCA-----------PPRT
Rv0399c|M.tuberculosis_H37Rv --------------MPVLRRLGCSVLALGLLAGCA-----------PPRT
MMAR_0696|M.marinum_M --------------MPILRRVAGVVFGVCLLAGCAALH--------PPQQ
MAB_0330|M.abscessus_ATCC_1997 MPELSTR---CFDESSLMRRILAVVLTIALLVSACGK----------HSA
Mvan_3027|M.vanbaalenii_PYR-1 MADENGRRDSAHTLGAMITRALPIVFAMVLALTACGESVDTTQTTGSRNP
TH_3520|M.thermoresistible__bu -----------MRAVRTLAALLLAVFAVSAGPSAAGQ-------------
MSMEG_4455|M.smegmatis_MC2_155 ----------MRIVRALVAAALVAAVSAGCSTSPDAA----------EEA
Mflv_3749|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1772|M.ulcerans_Agy99 ----------MGVARPRWRGPRAAWFAGARKPSDGRRLT-----------
MAV_3991|M.avium_104 ----------MLTLVAASSTGRVVHTSPSEAPPASMTP-----------H
Mb0405c|M.bovis_AF2122/97 GPASS-PTNNGAKADAVIRIVRDFMTQAHLKAVLVRVTVA--GKEVVTRA
Rv0399c|M.tuberculosis_H37Rv GPASS-PTNNGAKADAVIRIVRDFMTQAHLKAVLVRVTVA--GKEVVTRA
MMAR_0696|M.marinum_M SSAPTGPDGKGTKADAVMKVVRDFMGPAHLRSVIVRVSVD--GKEIVTDA
MAB_0330|M.abscessus_ATCC_1997 IVVA---ELDPQTTAKLDSAINEILTSAAVPGAIVGVWGP-KGQYVRTFG
Mvan_3027|M.vanbaalenii_PYR-1 AVTAPATTMAAEVTDRLDDAVERVMTEAGIPGAIVGIWGP-GGDYVRAFG
TH_3520|M.thermoresistible__bu ---------PPDLAAALDRAIELRLDQMGVPGAIVSLSIPGKIEYTRAFG
MSMEG_4455|M.smegmatis_MC2_155 FATTEPPALKTIDPAHLQSIVADTAKSLDVPGALVLLQTP-QGRFAAGVG
Mflv_3749|M.gilvum_PYR-GCK -----------MNLDRNKASIVDAIDAGLLAGAVTLVWHAGEVRQVNELG
MUL_1772|M.ulcerans_Agy99 -RRPPAANLNPVNLDANQADIREVCDAGLLSGAVTVVWQHGEVLQVNEIG
MAV_3991|M.avium_104 ASLVPESTSPAEDFTTISKLVNDAIAARGLPGAVVMVGHGGKVVFHQAYG
: : ..:. : .
Mb0405c|M.bovis_AF2122/97 VGDSMTG----------VPATTAMHFRNGAVAISYV-ATLLLKLVDEKKL
Rv0399c|M.tuberculosis_H37Rv VGDSMTG----------VPATTAMHFRNGAVAISYV-ATLLLKLVDEKKL
MMAR_0696|M.marinum_M VGDSMTG----------VPASTDMHFRNGAVAISYV-ATLLLKLVDEHKL
MAB_0330|M.abscessus_ATCC_1997 VANTATR----------APLRPDFYHRIGSVTKTFT-VTAVLQLVDEGKV
Mvan_3027|M.vanbaalenii_PYR-1 VADTKTR----------APMKTDFYSRIGSLTKTFT-VTAVLLLADQGRL
TH_3520|M.thermoresistible__bu VGDTATG----------TPMLVDNHHRIGSVTKTFI-GTAILQLADQGRI
MSMEG_4455|M.smegmatis_MC2_155 TTELGTQ----------TPPRPDTHFRIASNTKTMT-AAVIMLLAQDGKL
Mflv_3749|M.gilvum_PYR-GCK YRDVDAQ----------LPMQRDTIFRIASMTKPVT-VAAAMSLVEEGRL
MUL_1772|M.ulcerans_Agy99 YRDVEAG----------LPMQRDTLFRIASMTKPVT-VAAAMSMVDEGKI
MAV_3991|M.avium_104 SRKLAGEPGLDGAPAPAEPMTEDTIFDLASLTKCLATAVAVMQLYEQGKV
. * .: : . : : :: ::
Mb0405c|M.bovis_AF2122/97 RLDDKLSRWLPDFPHA-----------------DRVTLGQLAQMTSGYPD
Rv0399c|M.tuberculosis_H37Rv RLDDKLSRWLPDFPHA-----------------DRVTLGQLAQMTSGYPD
MMAR_0696|M.marinum_M SLDDKLSKWLPDFPHA-----------------DRVTLGQLAQMTSGYPD
MAB_0330|M.abscessus_ATCC_1997 ELDDPIAKYVDKVPNG-----------------NKITLRELARMQSGLFN
Mvan_3027|M.vanbaalenii_PYR-1 GLDDPIAGYVDGVPGG-----------------DAITLRQLARMQSGLPD
TH_3520|M.thermoresistible__bu RLSDPISRYVEGVPSG-----------------DVITLDMLARMRSGLAD
MSMEG_4455|M.smegmatis_MC2_155 SLDDPVAKYVPGVPNA-----------------DAITLIDLLRMRSGLYC
Mflv_3749|M.gilvum_PYR-GCK SLTDRVATWLPELADMRVLAEPRGALDRTVPAQRHITIEDLMTHRSGLAY
MUL_1772|M.ulcerans_Agy99 ALRDPITRWAPELRDIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAY
MAV_3991|M.avium_104 AFDDPVQKYLPAFNTTN------------DPQRAKVTIRMLLTNTSGEGI
: * : : . : : * **
Mb0405c|M.bovis_AF2122/97 YVLGNEAFDAELYANPFR-----QWTTQELLDQISSRPLLYDPGTNWNYA
Rv0399c|M.tuberculosis_H37Rv YVLGNEAFDAELYANPFR-----QWTTQELLDQISSRPLLYDPGTNWNYA
MMAR_0696|M.marinum_M YVLGNDEFGDALYADPFR-----QWTPQELLAQISSRPLLYEPGTNWNYA
MAB_0330|M.abscessus_ATCC_1997 YSM-SLAFSRDLEADPRR-----QYSTHELLDYAFAQPSNFVPGQGYEYS
Mvan_3027|M.vanbaalenii_PYR-1 YTA-NPEFVPTVIADPGR-----AFAPTEMLEFAFSQPPMFAPGDGYHYS
TH_3520|M.thermoresistible__bu YTE-TDEFVERLYRESPSGPDAFAVTPRELVESAFARPLNFAPGSEFEYS
MSMEG_4455|M.smegmatis_MC2_155 YTN-DSEFAATLDSDPAK-----TWTPQEVLDIAFDHPSTVAPDTAYEYC
Mflv_3749|M.gilvum_PYR-GCK MFSVLGPLSDAYRKLPTR------QDQDRWLTELSALPLVHQPGERLTYS
MUL_1772|M.ulcerans_Agy99 SFSVSGDISRAYMRLPFG------HGSDAWLAELAALPLVHQPGERVTYS
MAV_3991|M.avium_104 DVSLRDPWGLAGPDKAEG------------IHRALTTPLQSAPAGEFRYS
. : * * *.
Mb0405c|M.bovis_AF2122/97 HTNYLLLGLALEKAAGQDMPTLLQRKVLSPLGLTATANS-----------
Rv0399c|M.tuberculosis_H37Rv HTNYLLLGLALEKAAGQDMPTLLQRKVLSPLGLTATANS-----------
MMAR_0696|M.marinum_M HTNYVLLGLALEKATGQDMATLLKQKVLAPLGLTATANS-----------
MAB_0330|M.abscessus_ATCC_1997 NTNAVLLGQVVEKVSGQTLPAFVQEHITGPLGMRRTSFP-----------
Mvan_3027|M.vanbaalenii_PYR-1 NTNTVLLGLVVEKVSGQSLGDYIRRHISAPLGMAETSFP-----------
TH_3520|M.thermoresistible__bu NTNTVLLGMVVERVSGVPLARYLQDNIFGPVGLTQTSYP-----------
MSMEG_4455|M.smegmatis_MC2_155 NTNYALLGVVAEQVGGAPLAEQFQQRLFGPLGMRNTLLPS----------
Mflv_3749|M.gilvum_PYR-GCK HA-TDVLGIALSRIEGKPLSEVLAERIFEPLGMTDTGFS-----------
MUL_1772|M.ulcerans_Agy99 HA-IDLLGVIMSRIDDKPFYQVLDERILGPAGMTDTGFF-----------
MAV_3991|M.avium_104 DINYLLLGALLEKITGEDEDDYVQHHVFGPLGMHDTRYLPPAKACGPHII
. :** .: . . .: * *: *
Mb0405c|M.bovis_AF2122/97 ----------------------DTPAIPEPALHAFTSERRAALKIPAGVP
Rv0399c|M.tuberculosis_H37Rv ----------------------DTPAIPEPALHAFTSERRAALKIPAGVP
MMAR_0696|M.marinum_M ----------------------ETPSIPDPALHAFSAERRAFLKIPADTP
MAB_0330|M.abscessus_ATCC_1997 ----------------------ETSAIADPHARGYTQLTPTGSLVDS---
Mvan_3027|M.vanbaalenii_PYR-1 ----------------------TDATFPGPHATGYTVQPPDDREMTA---
TH_3520|M.thermoresistible__bu ----------------------ADGRLPAPYTHGYNQ-GPDGAIVDT---
MSMEG_4455|M.smegmatis_MC2_155 --------------------PAEASEIPAPYSHGYMYGETLYAMVDETYP
Mflv_3749|M.gilvum_PYR-GCK ----------------------VGSEGRRRAATMYQLDKDGTLRHDVMGP
MUL_1772|M.ulcerans_Agy99 ----------------------VSTQAQRRAATMYRLDELDQLRHDVMGP
MAV_3991|M.avium_104 RGAAIAWAPNGEPMTECPEWTWRTTLLPRIAPTARDEESRDDPSKNPDYY
Mb0405c|M.bovis_AF2122/97 FY------------EESTFWNPSWTITHGAIQTTTIYDMEATAVGIGSG-
Rv0399c|M.tuberculosis_H37Rv FY------------EESTFWNPSWTITHGAIQTTTIYDMEATAVGIGSG-
MMAR_0696|M.marinum_M FS------------EESTFWNPSWTITHGAIQTTTIYDMEATAVGIGSG-
MAB_0330|M.abscessus_ATCC_1997 -----------------TDWNPSWASWAGAMIS-TLDDLRIWVPALATG-
Mvan_3027|M.vanbaalenii_PYR-1 -----------------TDWNLSWSWAAGNMVS-TLHDLRIWAPALVTG-
TH_3520|M.thermoresistible__bu -----------------TLWNPAWADAAGKIVS-NVHDMRTWARALGSG-
MSMEG_4455|M.smegmatis_MC2_155 AAITDAARAGTLKPNDYTHQNSSYATAAGGAIS-TADDLATWIRALVGG-
Mflv_3749|M.gilvum_PYR-GCK ----------------APIVDPPFCTGGAGLFS-TVDDYLRFARMLLNGG
MUL_1772|M.ulcerans_Agy99 ----------------PHVRPPSFCNAGGGLWS-TADDYLRFVRLLLGDG
MAV_3991|M.avium_104 ALLRG-------TVHDPTARRMGGVAGNAGVFS-TAHDVGVYAQALLDRL
. : . * :
Mb0405c|M.bovis_AF2122/97 -----RLLSADSYKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLGIVIS
Rv0399c|M.tuberculosis_H37Rv -----RLLSADSYKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLGIVIS
MMAR_0696|M.marinum_M -----KLLSADSYQKMVSTALRGKTRAQPDCPTCFEQSEGYTYGLGIVIS
MAB_0330|M.abscessus_ATCC_1997 -----VLLKPDSQQQRLQTVA---MPPVPDD---------IRYGLGIFDA
Mvan_3027|M.vanbaalenii_PYR-1 -----TLLSRQMQQQRLQMVE---SSGQPAP---------EEYGLGMFNV
TH_3520|M.thermoresistible__bu -----ALLRPDTHAERIHGG----SSVVPG----------VDYSFAIFNA
MSMEG_4455|M.smegmatis_MC2_155 -----KVLDSEHQQQFLDSLLPEDPDNPDGG---------QSYGYGISFQ
Mflv_3749|M.gilvum_PYR-GCK TLDGTRVLSEDSAMSMRTDRLTAEQKRQDFLGAPFWIG--RGFGLNLSVV
MUL_1772|M.ulcerans_Agy99 TIDGVRVLSPESVRLMRTDRLSDEHKRHNFLGAPFWVG--RGFGLNLSVV
MAV_3991|M.avium_104 AGRPSDFPLQQGTVELMTTPQQPGHDPRQLEAANRAAR-SGTPNYPAIKG
. : .
Mb0405c|M.bovis_AF2122/97 GH-----WLLQNPMFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQGNYR
Rv0399c|M.tuberculosis_H37Rv GH-----WLLQNPMFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQGNYR
MMAR_0696|M.marinum_M GH-----WLLQNPLFSGYAATEAYLPSQRVAIAVALTYTPEAFDDEGNYP
MAB_0330|M.abscessus_ATCC_1997 RG-----WIGHSGSIPGYQTLAIYSPAEQTTVVALLN-----TDVAKQPA
Mvan_3027|M.vanbaalenii_PYR-1 AG-----WIGHNGSVPGYQTVSVYLPERQTALVILTN-----TDIAFRGA
TH_3520|M.thermoresistible__bu QG-----WLGHNGDIPGYATVVVYLPERDATLVVFVN-----SDVPEP--
MSMEG_4455|M.smegmatis_MC2_155 RFGPEAAMYYHGGEMPGFNSFMGYDPDNDVALVIWTN-----LTLSPDNK
Mflv_3749|M.gilvum_PYR-GCK TDPAKSRQLFGPGGLGTFSWPGAYGTWWQADPSADVILIYLIQNLPSMSV
MUL_1772|M.ulcerans_Agy99 TDPVQSTPLFGPGGLGTFSWPGAYGTWWQADPGADLILLYLIQHCPDLSV
MAV_3991|M.avium_104 QNLFGFGWDIDTGYSRPRGRVFPIGSFGNTGFTGTTLWMDPGSDTYVILL
. .
Mb0405c|M.bovis_AF2122/97 NQADILFRKIGAEVAPNDAPPMPPGR---------
Rv0399c|M.tuberculosis_H37Rv NQADILFRKIGAEVAPNDAPPMPPGR---------
MMAR_0696|M.marinum_M NQADILFRKIAAALVPDDAPPMPPGR---------
MAB_0330|M.abscessus_ATCC_1997 QPSTLFGTAITKVISPDHVFLLENAIPQPR-----
Mvan_3027|M.vanbaalenii_PYR-1 EPGTLLARAVTTELTPDHVYTLS------------
TH_3520|M.thermoresistible__bu HSAGQIAYVVTEMVTPEHIYELGPQPPQMLDEPAA
MSMEG_4455|M.smegmatis_MC2_155 TTANAMLPVVLKEIYSDLSF---------------
Mflv_3749|M.gilvum_PYR-GCK DVAAAIAGNTSLAKLQTAQPKFVRSTYQALEL---
MUL_1772|M.ulcerans_Agy99 NAAAAVAGNPGLAKLRTAQPRFVRRTYRALGL---
MAV_3991|M.avium_104 SNSIHLRGSPPISNLRGDVATAAARALHLYGAAPP
. .