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M. tuberculosis H37Rv Rv1664 (pks9)

annotation: Probable polyketide synthase pks9
coordinates: 1888026 - 1891079
length: 1017

VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMDPRQRLALELT
WELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTI
DSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDG
GGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAH
GTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAA
IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV
LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGA
GVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLE
STEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGG
VMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDP
MVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGP
GAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS
VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQ
MAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAG
QPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1664pks9-100% (1017)Probable polyketide synthase pks9
M. tuberculosis H37RvRv0405pks60.048.34% (995) membrane bound polyketide synthase
M. tuberculosis H37RvRv1662pks80.049.03% (924) polyketide synthase pks8

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1692pks90.099.80% (1017) polyketide synthase pks9
M. gilvum PYR-GCKMflv_0405-1e-15539.50% (914) beta-ketoacyl synthase
M. leprae Br4923MLBr_00135-0.048.14% (889) putative polyketide synthase
M. abscessus ATCC 19977MAB_0939-1e-15137.14% (902) polyketide synthase
M. marinum MMMAR_2473pks90.063.65% (1018) polyketide synthase Pks9
M. avium 104MAV_3107-0.063.89% (1044) polyketide synthase
M. smegmatis MC2 155MSMEG_0408-1e-15539.08% (888) type I modular polyketide synthase
M. thermoresistible (build 8)TH_4458-1e-14236.53% (1002) PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide
M. ulcerans Agy99MUL_1655pks90.063.06% (1018) polyketide synthase Pks9
M. vanbaalenii PYR-1Mvan_1000-1e-16739.06% (1001) amino acid adenylation domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0405|M.gilvum_PYR-GCK          ------------------------------MGSAAHQGESAHRFAIVGYA
MAB_0939|M.abscessus_ATCC_1997      ------------------------------MDSAENPIESTPRFAIIGYA
MSMEG_0408|M.smegmatis_MC2_155      ------------------------------MVSAEHPIEPTPSFAIIGYA
Rv1664|M.tuberculosis_H37Rv         --------------------------------------MQPTGIAIIGLA
Mb1692|M.bovis_AF2122/97            --------------------------------------MQPTGIAIIGLA
MAV_3107|M.avium_104                --------------------------------------MPPTDVAIIGMA
MMAR_2473|M.marinum_M               ----------------------MSRATSLRRQHGDGDQEFASAVAIIGVA
MUL_1655|M.ulcerans_Agy99           ---------------------MMSRATSLRRQHGDGDQEFASAVAIIGVA
MLBr_00135|M.leprae_Br4923          MTASVEGADQKSEKLISYLKKVVVELDETRARLREYEQRATEPVAVVGIG
Mvan_1000|M.vanbaalenii_PYR-1       -------------------------------------MTGQSGFAVVGYA
TH_4458|M.thermoresistible__bu      -------------------------------LLSLLRQRSERYGDKIAFD
                                                                                  :.  

Mflv_0405|M.gilvum_PYR-GCK          GRFPG-ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVV
MAB_0939|M.abscessus_ATCC_1997      ARFPG-AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVV
MSMEG_0408|M.smegmatis_MC2_155      ARFPG-AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVV
Rv1664|M.tuberculosis_H37Rv         CRFPT-VVSPGDLWDLLRDGREAA--------------------------
Mb1692|M.bovis_AF2122/97            CRFPT-VVSPGDLWDLLRDGREAT--------------------------
MAV_3107|M.avium_104                CRFPG-APDPGSFWRLLRDGREVT--------------------------
MMAR_2473|M.marinum_M               CRFPG-AANPGEFWELVSEGHEVA--------------------------
MUL_1655|M.ulcerans_Agy99           CRIPG-AANPGEFWELVSEGHEVA--------------------------
MLBr_00135|M.leprae_Br4923          CRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTY
Mvan_1000|M.vanbaalenii_PYR-1       VRFPG-AADAREFWDVLAEGRDAVSEVPADR-WDVDEFFDADPDAAGKMV
TH_4458|M.thermoresistible__bu      YCTGEQEHSRLTYQELDIRARAIAAHLQDQG-------------VAGERV
                                            .      :    :                             

Mflv_0405|M.gilvum_PYR-GCK          TRRAGFVDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAP
MAB_0939|M.abscessus_ATCC_1997      TRRAGFVEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAP
MSMEG_0408|M.smegmatis_MC2_155      TRRAGFVDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAP
Rv1664|M.tuberculosis_H37Rv         ----GSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVP
Mb1692|M.bovis_AF2122/97            ----GSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVP
MAV_3107|M.avium_104                ----RFAGEAAEFDADFFNLSPREAAAMDPRQRLALELAWELLEDAFIVA
MMAR_2473|M.marinum_M               ----KPIDHVGDFDAEFFNVSPREAAAMDPRQRLALELAWELFEDARIVA
MUL_1655|M.ulcerans_Agy99           ----KPIDHVGDFDAEFFNVSPREATAMDPRQRLALELAWELFEDARIVA
MLBr_00135|M.leprae_Br4923          TRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDP
Mvan_1000|M.vanbaalenii_PYR-1       SRRAGFVDDVAGFDAPFFGVSAREAMFMDPQHRLVLETAWSAVEHAGIAP
TH_4458|M.thermoresistible__bu      LVLCPSGLDFITAMFGCFYVGAVAVPVHPPVHNRLLSRVASIVADVRATS
                                            .        * :..  .    * :.  :.     .      .

Mflv_0405|M.gilvum_PYR-GCK          SELANTNTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRIS
MAB_0939|M.abscessus_ATCC_1997      TDLAETNSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRIS
MSMEG_0408|M.smegmatis_MC2_155      TSLANSNTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRIS
Rv1664|M.tuberculosis_H37Rv         ETLRGQPIAVYLGAMNDDYA-VLTL--AADRVDHHAFAGTSRAIIANRVS
Mb1692|M.bovis_AF2122/97            ETLRGQPIAVYLGAMNDDYA-VLTL--AADRVDHHAFAGTSRAIIANRVS
MAV_3107|M.avium_104                ETLRGEAVSVYLGAMTDDYA-ALTLRDVPDNVDHHTFTGVSRGMIANRIS
MMAR_2473|M.marinum_M               ESVRGEPIAVYLGAMNDDYA-LLTLDQAPDKLDHYSFAGASRGMIANRVS
MUL_1655|M.ulcerans_Agy99           ESVRGEPIAVYLGAMNDDYA-LLTLDQAPDKLDHYSFAGASRGMIANRVS
MLBr_00135|M.leprae_Br4923          LSLRGSATGVFTGIFAPSYG-SRDT----GGLQGYGLTGTAVSVASGRVS
Mvan_1000|M.vanbaalenii_PYR-1       EALAGTRTGVFLGLSTHEFLGMLIAHTGYEDVDIYSGTGTSPAAAAGRVS
TH_4458|M.thermoresistible__bu      VLTTAATRADLKEILDGLHDGDPLRWLAVDTIEADDETSWTPTTVDTDSV
                                            .         .            ::     . :         

Mflv_0405|M.gilvum_PYR-GCK          YRLGLQGPAVAVDTACSSSLVAIHQACQALR-LGECDLALAGGANVILTP
MAB_0939|M.abscessus_ATCC_1997      YRLGLQGPSVAVDTACSSSLVAIHQACQALQ-LGECDLALAGGANVLLTP
MSMEG_0408|M.smegmatis_MC2_155      YRLGLQGPAVAVDTACSSSLVAIHQACQALR-LNECDLALAGGANVLLTP
Rv1664|M.tuberculosis_H37Rv         FAFGLRGPSVTIDSGQSSSLVAVHLACESVR-TGEAPLAIAGGVHLNLAR
Mb1692|M.bovis_AF2122/97            FAFGLRGPSVTIDSGQSSSLVAVHLACESVR-TGEAPLAIAGGVHLNLAR
MAV_3107|M.avium_104                YLLGLRGASMTVDSGQSSSLVAVHLGCESVR-SGQAPLAIAGGVHLNLAD
MMAR_2473|M.marinum_M               YGFALHGPSMTVDCGQSSSLVAVHLAREYLRGAGDATMAIAGGIHLNLAS
MUL_1655|M.ulcerans_Agy99           SGFALHGPSMTVDCGQSSSLVAVHLAPGYLRGAGDATMAIAGGIHLNLAS
MLBr_00135|M.leprae_Br4923          YVLGLEGPAVSVDTACSSSLVAIHWAMSSLR-SGECDLALAGGVTVMGLP
Mvan_1000|M.vanbaalenii_PYR-1       FRMGLQGPAVAVDTACSSSLVAVHQACQALR-DGDCDTALVGGVNVILTP
TH_4458|M.thermoresistible__bu      AFVQYTSGSTSTPKGVVLTHHNLLANLESISRDAGQGDEARVVSWLPLHH
                                      .   . : :   .   :   :      :               :    

Mflv_0405|M.gilvum_PYR-GCK          ATMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDG-
MAB_0939|M.abscessus_ATCC_1997      ATMITFSHAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDG-
MSMEG_0408|M.smegmatis_MC2_155      ATMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDG-
Rv1664|M.tuberculosis_H37Rv         ETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDG-
Mb1692|M.bovis_AF2122/97            ETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDG-
MAV_3107|M.avium_104                EIALLEREFGAVSVSGHTYAFDRRADGYVRGEGGGLVLLKPLAAARRDG-
MMAR_2473|M.marinum_M               ETGRLETEFGAVSASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDG-
MUL_1655|M.ulcerans_Agy99           ETGRLETEFGAVSASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDG-
MLBr_00135|M.leprae_Br4923          SIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLG-
Mvan_1000|M.vanbaalenii_PYR-1       VPMINLTRARMLAPDGRCKTFDAAADGYVRGEGCGVVVLKRTGDALRDG-
TH_4458|M.thermoresistible__bu      DMGLIGGIFGVVHFGG--TAYLMPPSSFIQRPMSWLEAISWHGANISVGP
                                               :  .*   ::   ...        :  :.        * 

Mflv_0405|M.gilvum_PYR-GCK          --------DRIRAVIRGSAINQDGASG-GLTVPNGVAQQRVIGDALSRAG
MAB_0939|M.abscessus_ATCC_1997      --------DRIRAVIRGSAINQDGASG-GLTVPNGVAQQRVIADALKRAG
MSMEG_0408|M.smegmatis_MC2_155      --------DRIRAVIRGSAINQDGASG-GLTVPNGVAQQRVIADALKRAG
Rv1664|M.tuberculosis_H37Rv         --------DRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAG
Mb1692|M.bovis_AF2122/97            --------DRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAG
MAV_3107|M.avium_104                --------DRIHAVIRATAVGNAGHGAPAQTLPSAAAEADVIGRALAEAG
MMAR_2473|M.marinum_M               --------NRIRAVILGAAVGSAGHTAGGLAAPSAAAEADVMRRAMASAG
MUL_1655|M.ulcerans_Agy99           --------NSIRAVILGEAVGSAGHTAGGLAAPSAAAEADVMRRAMASAG
MLBr_00135|M.leprae_Br4923          --------HTVLAVVRGSAVNQDGASN-GLTAPNGLAQQRVIQAALTNAG
Mvan_1000|M.vanbaalenii_PYR-1       --------DRIRAVIRGSAVNQDGASG-GLTVPNGVAQQHVIADALRRAG
TH_4458|M.thermoresistible__bu      NFGYQLCVERSTPEERATLDLSTWVRAYCGAEPVRAATMRRFTEAFAPAG
                                            .   .   .    .        : *   .    :  *:  **

Mflv_0405|M.gilvum_PYR-GCK          LAPGDVD--YLEAHGTGTSLGDPIEAQAAGAALGPGREPQRPLLIGSAKT
MAB_0939|M.abscessus_ATCC_1997      VAPSEVG--YLEAHGTGTSLGDPIEAQAAGAAYGIGRETNDPLLIGSAKT
MSMEG_0408|M.smegmatis_MC2_155      LRPADVG--YLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLIGSAKT
Rv1664|M.tuberculosis_H37Rv         VDCHQVH--YVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKT
Mb1692|M.bovis_AF2122/97            VDCHQVH--YVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKT
MAV_3107|M.avium_104                LGGADID--YVEAHGTGTRVGDAVETQALGRIFAERS--HHPVSVGSVKT
MMAR_2473|M.marinum_M               VDPNQID--YIEAHGTGTRIGDTTEAQALSEVFATR---ETPVWLGSVKS
MUL_1655|M.ulcerans_Agy99           VDPNQID--YIEAHGTGTRIGDTTEAQALSEVFATR---ETPVWLGSVKS
MLBr_00135|M.leprae_Br4923          LSSADVD--VVEAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKS
Mvan_1000|M.vanbaalenii_PYR-1       LGGGEVD--YLEAHGTGTSLGDPIEVQAAAAAFGDGRDPDRPLLIGSVKT
TH_4458|M.thermoresistible__bu      FRADAFHPVYGLAEATLFVSGRPENVLPTVRSLDNAALREHRVVPAAADD
                                    .    .      *..*    * . :. .              :  .: . 

Mflv_0405|M.gilvum_PYR-GCK          NIGHLEAAAGIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVK
MAB_0939|M.abscessus_ATCC_1997      NIGHLEAAAGIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVR
MSMEG_0408|M.smegmatis_MC2_155      NIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLPIEVVR
Rv1664|M.tuberculosis_H37Rv         NIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVG--AAIDLDSLGLRVDT
Mb1692|M.bovis_AF2122/97            NIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVG--APIDLDSLGLRVDT
MAV_3107|M.avium_104                NIGHAASAAGIAGLLKAVLAIEHAAIPPNLHFERPDPDIDLNRLGLRVNT
MMAR_2473|M.marinum_M               NIGHTGAAAGAAGLIKTVLSLENGAIPASLNYVGDSAGTDMESHGLHVST
MUL_1655|M.ulcerans_Agy99           NIGHTGAAAGAAGLIKTVLSLENGAIPASLNFVGDSAGTDMESHGLHVST
MLBr_00135|M.leprae_Br4923          NMGHTQAAAGVAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLT
Mvan_1000|M.vanbaalenii_PYR-1       NIGHLEAASGIAGLIKVVLSLEHETLPVHLHLRRPSPHIPWERLPVRVVA
TH_4458|M.thermoresistible__bu      ANAAAVVGCGPAAYGEEIVIVDPATRREFPPDVVGEIWVAGENVAQGYLG
                                      .    ..* *.  : :  :                             

Mflv_0405|M.gilvum_PYR-GCK          ESIPWRRGQRGGRPRIAGVSSFGFAGTNAHVILEEAPLAA--EPAQES--
MAB_0939|M.abscessus_ATCC_1997      EARPWGR---NGRPRIAGVSSFGFAGTNAHVILEEAPVVS--RDAVEPPA
MSMEG_0408|M.smegmatis_MC2_155      ETVPWQR---NGKPRIAGVSSFGFAGTNAHVILEEAPAVG--TPATTEP-
Rv1664|M.tuberculosis_H37Rv         ALTPWPV---ADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAA
Mb1692|M.bovis_AF2122/97            ALTPWPV---ADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAA
MAV_3107|M.avium_104                ALAPWPD---RGGPRRAGVSSFGMGGTNAHVIVEQDAAQ-----QNPTPA
MMAR_2473|M.marinum_M               TLTPWPR---GAGPRRAGVSSFGMGGTNAHVIVQQAPIP-----QEAVAD
MUL_1655|M.ulcerans_Agy99           TLTPWPR---GAGPRRAGVSSFGMGGTNAHVIVQQAPIP-----QEAVAD
MLBr_00135|M.leprae_Br4923          EARDWSV---EGRPRRAGVSSFGISGTNAHVILEEAPTP---VEASYSTA
Mvan_1000|M.vanbaalenii_PYR-1       EATPWQR---NDRPRIAGVSSFGFSGTNAHVLLEEAPVAS----PTEEPD
TH_4458|M.thermoresistible__bu      KPSESAET-FAAHLADSGRGPFLRTGDYGFLLDGELFVTG----RLKDLI
                                                    :* ..*   *  ..::  :               

Mflv_0405|M.gilvum_PYR-GCK          -VDDGRFTLLPLSARTPAALMAVADRYRDWLVANPDATLADLCFTAGTAR
MAB_0939|M.abscessus_ATCC_1997      PAGGRKFSILPLSARTPAALAQLADKYRAWLNAHPEAALADLCFTAGVGR
MSMEG_0408|M.smegmatis_MC2_155      VEDPRRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAGTAR
Rv1664|M.tuberculosis_H37Rv         GSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR
Mb1692|M.bovis_AF2122/97            GSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR
MAV_3107|M.avium_104                SAPADVALPWVLSARSERALALQAQRLSAHLAERPQASPLDVGWSLVSAR
MMAR_2473|M.marinum_M               PDGTEATVPWLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTR
MUL_1655|M.ulcerans_Agy99           PDGTEATVPWLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTR
MLBr_00135|M.leprae_Br4923          DQQRLSVVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALA-AR
Mvan_1000|M.vanbaalenii_PYR-1       EAPHRRYHLLPLSARTPEALVRLASRHLAYLEDDPDATIVDICAAAGAGR
TH_4458|M.thermoresistible__bu      IIRGRNYHPNDIEATVQEVHPALMSGRGAAFAVSP-----DPSGTEQLVI
                                               : .    .           .         *   :     

Mflv_0405|M.gilvum_PYR-GCK          SHLEHRAALVVNTREAALDLLGALADDRPAPGLVRGESHDTPKTAWLFTG
MAB_0939|M.abscessus_ATCC_1997      AHLEHRAALVVNTREAAVELLSAVADDRPAPGLGRGESHDTPKTAWLFTG
MSMEG_0408|M.smegmatis_MC2_155      AHLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWLFTG
Rv1664|M.tuberculosis_H37Rv         SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG
Mb1692|M.bovis_AF2122/97            SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG
MAV_3107|M.avium_104                AVFEHRAVLVGCERGVLATGLAGVASGRPDAATVVGRARATGKTVLVFPG
MMAR_2473|M.marinum_M               SVFEHRAVLVGGDRGGFMAGLAALASGEPGVNLVAGRAGSGGKTVLVFPG
MUL_1655|M.ulcerans_Agy99           SVFEHRAVLVGGDRGGFMAGLAALASGEPGVNLVAGRAGSGGKTVLVFPG
MLBr_00135|M.leprae_Br4923          SVFEHRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPG
Mvan_1000|M.vanbaalenii_PYR-1       SHFEHRAALVVDSRPRARRLLRAIHEERPAPGLVRGVCSDRPKTAWLFGG
TH_4458|M.thermoresistible__bu      VQEVDRGRLGEVDTDELIAAIRTAVTSQHDIGVHTVVLVDPLRIPTTSSG
                                        .*. :           :      .              :      *

Mflv_0405|M.gilvum_PYR-GCK          QGSQYPGMSRELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLD
MAB_0939|M.abscessus_ATCC_1997      QGSQYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD---G
MSMEG_0408|M.smegmatis_MC2_155      QGSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDAD-ELD
Rv1664|M.tuberculosis_H37Rv         QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG------
Mb1692|M.bovis_AF2122/97            QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG------
MAV_3107|M.avium_104                QGSQTLGMGRQLYERFVVFARALDEAVAVVDEHSRLSVREVMWG------
MMAR_2473|M.marinum_M               QGAQWLGMGRDLYGRFPAFAKAFDTVADALDEHLRLPLREVIWG------
MUL_1655|M.ulcerans_Agy99           QGAQWLGMGRDLYGRFPAFAKAFDTVADALDEHLRLPLREVIWG------
MLBr_00135|M.leprae_Br4923          QGAQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWG------
Mvan_1000|M.vanbaalenii_PYR-1       QGNQFPGMAREVFDHEPVFAQTLRRCGEVLDGLLPRPLLEVIFDTG----
TH_4458|M.thermoresistible__bu      KIRRRTCRQRFLDGELDAFAEWRLATPRPAQPVPAADEQADEQAG-----
                                    :  :     * :      **                              

Mflv_0405|M.gilvum_PYR-GCK          TDSNETLRHTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAAC
MAB_0939|M.abscessus_ATCC_1997      PEAEETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAAC
MSMEG_0408|M.smegmatis_MC2_155      GDTESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSAAC
Rv1664|M.tuberculosis_H37Rv         -ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAY
Mb1692|M.bovis_AF2122/97            -ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAY
MAV_3107|M.avium_104                -ADPELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAAC
MMAR_2473|M.marinum_M               -ADASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEISAAH
MUL_1655|M.ulcerans_Agy99           -ADASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEISAAH
MLBr_00135|M.leprae_Br4923          -ADAGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAY
Mvan_1000|M.vanbaalenii_PYR-1       PEAEHNLRNTAFAQPALFAVEMGMARLWRSWGVEPDVVLGHSVGQYAAAC
TH_4458|M.thermoresistible__bu      --AGPGAGPGADEIRAWFVAQLAGELGLSPDDIDTGQPFAYYG--LDSVR
                                                   * *. ::.        .. ..  ..:      :. 

Mflv_0405|M.gilvum_PYR-GCK          VAGVLSLRDGARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEYPAL
MAB_0939|M.abscessus_ATCC_1997      VAEVFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEFPSL
MSMEG_0408|M.smegmatis_MC2_155      VAGVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEYPSL
Rv1664|M.tuberculosis_H37Rv         VAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEG--V
Mb1692|M.bovis_AF2122/97            VAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEG--V
MAV_3107|M.avium_104                VAGVLSLRDAARLVAARGALMAALPPGGVMVAVTATEAQVAPLVGGG--V
MMAR_2473|M.marinum_M               VAGVLSLTDAARLVSARGRLMAQLPPGGVMVAVAASAAQVAPMLEEG--V
MUL_1655|M.ulcerans_Agy99           VAGVLSLTDAARLVSARGRLMAQLPPGGVMVAVAASAAQVAPMLQEG--V
MLBr_00135|M.leprae_Br4923          VAGVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEG--V
Mvan_1000|M.vanbaalenii_PYR-1       VAGVFGLDEGARLIAERGRLFANLPSGGRMLAVFADPDRVERCTAEHSRL
TH_4458|M.thermoresistible__bu      AIQLMTALEAWSGIKVAPTLAYDHPTIDLAAEHLAGLTHTATSTAADAGV
                                    .   :   :.   :     *    *. .      :   ..         :

Mflv_0405|M.gilvum_PYR-GCK          SVAAYNGAN-TVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALLDP
MAB_0939|M.abscessus_ATCC_1997      SVAAYNGAN-TVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLDP
MSMEG_0408|M.smegmatis_MC2_155      SVAAYNGAN-TVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLDP
Rv1664|M.tuberculosis_H37Rv         CIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDP
Mb1692|M.bovis_AF2122/97            CIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDP
MAV_3107|M.avium_104                SIAAVNGPDAVVLSGEQEAVSAVAERLAGSGARVHRLAVSHAFHSALMEP
MMAR_2473|M.marinum_M               SIAAVNGPDSVVISGPEAATAVVADRLTGQGCRAHRLAVSHAFHSALMEP
MUL_1655|M.ulcerans_Agy99           SIAAVNGPDSVVISGPEAATAVVADRLTGQGCRAHRLAVSHAFHSALMEP
MLBr_00135|M.leprae_Br4923          GIAAINAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEP
Mvan_1000|M.vanbaalenii_PYR-1       SVAAYNGAN-TVLSGPAPDLEQVHAELTAAGSRCDWLDTSHAFHSALVDP
TH_4458|M.thermoresistible__bu      STGAGRRPE----HGPAPDRADEPIAIIGIGCRFPGADGPAAYWRLLRE-
                                      .* . .:     *           : . * *      . *:   * : 

Mflv_0405|M.gilvum_PYR-GCK          ILDDFESYARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQPVE
MAB_0939|M.abscessus_ATCC_1997      ILDEFEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVE
MSMEG_0408|M.smegmatis_MC2_155      ILDDFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVE
Rv1664|M.tuberculosis_H37Rv         MVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPA-YWVEHVRKPVR
Mb1692|M.bovis_AF2122/97            MVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPA-YWVEHVRKPVR
MAV_3107|M.avium_104                MLDGFAAAAAGIEPRPPRIPLVSNLTGQLAGPGYGTPQ-YWVEHVRRPVR
MMAR_2473|M.marinum_M               MMAQFGATISGIVAHEPRIALVSTMTGQLAAAGYGTAS-YWVEHVRKPVR
MUL_1655|M.ulcerans_Agy99           MMVQFGATISGIVAHEPRIALVSNMTGQLAAAGYGTAS-YWVEHVRKPVR
MLBr_00135|M.leprae_Br4923          MLEEFVRVAAQVEVRKPQIGLVSNVTGELAGPDFGSPQ-YWGEHVSRAVR
Mvan_1000|M.vanbaalenii_PYR-1       ALDEFESFAAQFEYRAPKLTLVCNRTGKVLTRQTRLDAPYWRRHAREPVR
TH_4458|M.thermoresistible__bu      --GRDAITATPPERWDTDSVGDGTRWGGFLERIDGFDAGFFGISPREAVR
                                                    .      .  *            ::     ..*.

Mflv_0405|M.gilvum_PYR-GCK          FAKSVHTLADMNCKLLVEIGPRPVLTAAALSAWPDPATSPRVIASLRRTT
MAB_0939|M.abscessus_ATCC_1997      FAKSVRTLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRNT
MSMEG_0408|M.smegmatis_MC2_155      FAKSVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRPTT
Rv1664|M.tuberculosis_H37Rv         FFDGVGLAESLGARVFVEVGPGAGLEASV--------------ALLARDR
Mb1692|M.bovis_AF2122/97            FFDGVGLAESLGARVFVEVGPGAGLEASV--------------ALLARDR
MAV_3107|M.avium_104                FVDGVRLAESQGAGVFLEVGPGAALTAAVDQ--SLSTEGATAIATLPKDR
MMAR_2473|M.marinum_M               FADGVALAESLGAATFLETGPSAGLGTSV--------------ALLAKGR
MUL_1655|M.ulcerans_Agy99           FADGVALAESLGAATFLETGPSAGLGTSV--------------ALLAKGR
MLBr_00135|M.leprae_Br4923          FVDSARHLQTLGATHFIESGPSSGLMGAIEQ--SLAPAEAVVVSMMGKDR
Mvan_1000|M.vanbaalenii_PYR-1       FADSAATLADLGCAVLMELGPQPVLIAAALRNWPETAPVPTAIASLRRDA
TH_4458|M.thermoresistible__bu      IDPQQRLLLEVAWEALEDAGLVPDRLAGS-----------------RTGV
                                    :              : : *  .                           

Mflv_0405|M.gilvum_PYR-GCK          ADQRQITEAVADAYVLGHLPRFA-AFRRDGARVLDLPTYPFEHRQYWFSD
MAB_0939|M.abscessus_ATCC_1997      ADHRQITEAAADAYVLGHLPDFG-AFQHAPARKLDLPTYPFERRQYWFSD
MSMEG_0408|M.smegmatis_MC2_155      ADHRQITEAVAAAYAAGHLPDFR-AFRQPDARKLDLPTYPFEHRQFWFSD
Rv1664|M.tuberculosis_H37Rv         PEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLG-
Mb1692|M.bovis_AF2122/97            PEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLG-
MAV_3107|M.avium_104                PETESALHAAGHLFTRGHRLDWAGVFAGLPARRVDLPTYAFARERFWLGG
MMAR_2473|M.marinum_M               PEVESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTYSFARQRFWLG-
MUL_1655|M.ulcerans_Agy99           PEVESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTYSFARQRFWLG-
MLBr_00135|M.leprae_Br4923          PELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETP
Mvan_1000|M.vanbaalenii_PYR-1       DAHRCFTDALGVAYTTGHRLDFAGHLG--RRRTLDLPTYPFEHRAYWFPT
TH_4458|M.thermoresistible__bu      FTGVSTYDYLHLQLSHPELIDAYSGTGTASSIAANRLSYVFDFRGPSLTL
                                                                         :* *  .      

Mflv_0405|M.gilvum_PYR-GCK          SRE---PVAAAPQR---GARTETVRLLEDGRIEELAALLGGTVDDPFTFD
MAB_0939|M.abscessus_ATCC_1997      KRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTLN
MSMEG_0408|M.smegmatis_MC2_155      NRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLR
Rv1664|M.tuberculosis_H37Rv         ------DNGELSVDQTGKDAG-----------------------------
Mb1692|M.bovis_AF2122/97            ------DNGELSVDQTGKDAG-----------------------------
MAV_3107|M.avium_104                ASLAGAPAGAAPVGGGTRAPE-----------------------------
MMAR_2473|M.marinum_M               -------EGAGRKADSSDESG-----------------------------
MUL_1655|M.ulcerans_Agy99           -------EGAGRKADSSDESG-----------------------------
MLBr_00135|M.leprae_Br4923          G-----TDGTASVSGLGLGST-----------------------------
Mvan_1000|M.vanbaalenii_PYR-1       TKVHTLPAGGGVESPAAESNTGDWLTGMSDEQRIDRIIELTRTELGNALR
TH_4458|M.thermoresistible__bu      DSACSSSLVAVHQACRSLRDGE----------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VLNRLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVGD
MAB_0939|M.abscessus_ATCC_1997      VLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVAD
MSMEG_0408|M.smegmatis_MC2_155      VLNKLAARHNQQRSTHVDPDARYEIRWDAIASAAASTGAAA--DWILVGD
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       VAPAEIDPTAEFMTIGMDSMIAMELRGRLQAALGTPVPASLFFENPTVST
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          DTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLRI
MAB_0939|M.abscessus_ATCC_1997      AAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALRI
MSMEG_0408|M.smegmatis_MC2_155      DTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELYV
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       LAEALHALWLDASSDPSRRESPIPRVPHGCTLPCDVPLSHAQEQLWFLNQ
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMWLVTR
MAB_0939|M.abscessus_ATCC_1997      VHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIWIVTR
MSMEG_0408|M.smegmatis_MC2_155      VHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTR
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       LLPSSSAYNVA---------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          GAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDEWSRL
MAB_0939|M.abscessus_ATCC_1997      GAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDEWAQF
MSMEG_0408|M.smegmatis_MC2_155      DGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSGADT-EWPRL
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRADATYL
MAB_0939|M.abscessus_ATCC_1997      IGRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSDATYL
MSMEG_0408|M.smegmatis_MC2_155      IARITSPRDG---EDQIALRGDAVYAPRLVRRTGEPSDTPLPVREDRTYL
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEALRERHGCE
MAB_0939|M.abscessus_ATCC_1997      VTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDALAA-QGCE
MSMEG_0408|M.smegmatis_MC2_155      VTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQYACD
Rv1664|M.tuberculosis_H37Rv         -----------------------------------AIARLQSLAP-----
Mb1692|M.bovis_AF2122/97            -----------------------------------AIARLQSLAP-----
MAV_3107|M.avium_104                -----------------------------------LAHRLHALPR-----
MMAR_2473|M.marinum_M               -----------------------------------LRPRLDSVDS-----
MUL_1655|M.ulcerans_Agy99           -----------------------------------LRPRLDSVDS-----
MLBr_00135|M.leprae_Br4923          -----------------------------------EHALLGAVVERPDSG
Mvan_1000|M.vanbaalenii_PYR-1       ----------------------IRVDIRGALDHEVLQRSLEAVVDRHEAL
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VRVVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAE
MAB_0939|M.abscessus_ATCC_1997      VRAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAE
MSMEG_0408|M.smegmatis_MC2_155      VRVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAE
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          GVVLTGRL------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       RTVFQSRHGAPQAILTPSQPIKLAFEEIGDEADIAAAAVREASVPFDIGA
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWGGFGQAAYGAA
MAB_0939|M.abscessus_ATCC_1997      VDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAA
MSMEG_0408|M.smegmatis_MC2_155      VDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAA
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ----------------------SLANQPWLADHVIGGVVLFPGAGFVELV
Mvan_1000|M.vanbaalenii_PYR-1       GPLLRARLFGVGDQRHVLVVTMHHIVTDGWSFRVLLGDLGRTYQALERGA
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          NAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPA
MAB_0939|M.abscessus_ATCC_1997      NAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPT
MSMEG_0408|M.smegmatis_MC2_155      NAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPA
Rv1664|M.tuberculosis_H37Rv         ----PELQRQLVELVCFHAAIVLGRKSSHDIDPEC---------------
Mb1692|M.bovis_AF2122/97            ----PELQRQLVELVCFHAAIVLGRKSSHDIDPEC---------------
MAV_3107|M.avium_104                ----DEQQRVLRELVCEHAAAVLGHPGGDAIDPDR---------------
MMAR_2473|M.marinum_M               ----KERFRQLVDLVCLHAAIVTGHSNSHQIDAER---------------
MUL_1655|M.ulcerans_Agy99           ----KERFRQLVDLVCLHAAIATGHSNSHQIDAER---------------
MLBr_00135|M.leprae_Br4923          IRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVV---------------
Mvan_1000|M.vanbaalenii_PYR-1       PAPLDDLPIQYADYARWQREQLTGPEFDAHIEFWK---------------
TH_4458|M.thermoresistible__bu      ----CDLALAGGVNIMLSAGIGLNFTRAGVMATDG---------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          DALAGLSDAVISAAP---HPVVARVDWSRFLPLYQQAGRRGFLAELEREL
MAB_0939|M.abscessus_ATCC_1997      DALAGLADVVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREV
MSMEG_0408|M.smegmatis_MC2_155      EALAGMADVVAGPVQ----GVVAKIDWSRFLPLYQQAGRRAFLSELESEL
Rv1664|M.tuberculosis_H37Rv         -AFQDLG-------------------------------------------
Mb1692|M.bovis_AF2122/97            -AFQDLG-------------------------------------------
MAV_3107|M.avium_104                -AFADLG-------------------------------------------
MMAR_2473|M.marinum_M               -AFQDLG-------------------------------------------
MUL_1655|M.ulcerans_Agy99           -AFQGLG-------------------------------------------
MLBr_00135|M.leprae_Br4923          -AAADESSRRAVSVY-----------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       -ADLAGAPPLELDTD-----------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          PAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVD
MAB_0939|M.abscessus_ATCC_1997      PSHLA--GVAGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVD
MSMEG_0408|M.smegmatis_MC2_155      PAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVD
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          -----SRGDQSHGGWLLNAEGLLEVDAAEATVDLSLWPPEGAESVDISDA
Mvan_1000|M.vanbaalenii_PYR-1       -----RPRPKSPTFRGARIRFDLGRERADALRDLCRAGNVTLSVPLLAAF
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AAEIREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAA
MAB_0939|M.abscessus_ATCC_1997      VSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVA
MSMEG_0408|M.smegmatis_MC2_155      ADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAA
Rv1664|M.tuberculosis_H37Rv         --------------FDSMSGVELRNR-----------------------L
Mb1692|M.bovis_AF2122/97            --------------FDSMSGVELRNR-----------------------L
MAV_3107|M.avium_104                --------------FDSLIGVELRNR-----------------------L
MMAR_2473|M.marinum_M               --------------FESMTGVELRNR-----------------------L
MUL_1655|M.ulcerans_Agy99           --------------FESMTGVELRNR-----------------------L
MLBr_00135|M.leprae_Br4923          YPQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPTGVVVDGMGMHPALL
Mvan_1000|M.vanbaalenii_PYR-1       ATVLQRYSGQHDLVIGTLTANRGRLETENLIGLFVNALPIRIRLDGDPDM
TH_4458|M.thermoresistible__bu      ----------RCKTFDARADGWVRGE---------------------GAG
                                                  :        *                          

Mflv_0405|M.gilvum_PYR-GCK          DYLLGDVLGLTEAAT-APKAATVVSTAADEPIAIVAVSCRFPGAPNPEAF
MAB_0939|M.abscessus_ATCC_1997      DYLLGDVLGLAEQAKPAAQLASAVTGRTDEPIAIVAVSCRFPGAPDPEAF
MSMEG_0408|M.smegmatis_MC2_155      DYLLVEVLGLGEQTN--VRQASTVTARTDDPIAVVAVSCRFPGAPDPESF
Rv1664|M.tuberculosis_H37Rv         QMAIGLPGLSLPRT------------------------------------
Mb1692|M.bovis_AF2122/97            QMAIGLPGLSLPRT------------------------------------
MAV_3107|M.avium_104                TTHT---GTALSRT------------------------------------
MMAR_2473|M.marinum_M               RAVT---GLALSRT------------------------------------
MUL_1655|M.ulcerans_Agy99           RAVT---GLALSRT------------------------------------
MLBr_00135|M.leprae_Br4923          DAVLHALGLAIENTQ-----------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       TELIDRIRGRMSEVL-----------------------------------
TH_4458|M.thermoresistible__bu      IVVLKPLREALADED-----------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          WDLLSGGVDAIREVPEDRFDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFD
MAB_0939|M.abscessus_ATCC_1997      WDVLSGGVDAIREVPEDRFDIDEFYDPDPEVAGKTYTRFGGFLDGIDGFD
MSMEG_0408|M.smegmatis_MC2_155      WELLAGGVDAIREVPEDRWDIDEFYDPDPDTPGKTYTRFGGFLDGIDGFD
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------ATTEMR
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------AHQDVP
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          PEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGV
MAB_0939|M.abscessus_ATCC_1997      PEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAGV
MSMEG_0408|M.smegmatis_MC2_155      PEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFTGV
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          LPFCWRGVSLHAGGAGRVRARFTSAGADAIAVDIADSA------------
Mvan_1000|M.vanbaalenii_PYR-1       FDLIVTATAPDRDASRNPLFGVQLVVQPAAGAAELSSLGLDVAEIDTHTA
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTA
MAB_0939|M.abscessus_ATCC_1997      GANEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDTA
MSMEG_0408|M.smegmatis_MC2_155      AANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDTA
Rv1664|M.tuberculosis_H37Rv         -----------------------------------LIFDYPTASALAECL
Mb1692|M.bovis_AF2122/97            -----------------------------------LIFDYPTASALAECL
MAV_3107|M.avium_104                -----------------------------------LIFDYPTPAALADHL
MMAR_2473|M.marinum_M               -----------------------------------IIFDYPTPMALARHL
MUL_1655|M.ulcerans_Agy99           -----------------------------------IIFDYTTPMALARHL
MLBr_00135|M.leprae_Br4923          ------------------------------GLPVLTVRSLVTRAMTAEQL
Mvan_1000|M.vanbaalenii_PYR-1       KRDLTLTFFDDELLAGHVEYATELFDEARIERLIAHFREVVDALVSDRRL
TH_4458|M.thermoresistible__bu      -----------------------------------PIYAVIRGSAVNQDG
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          CSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVG
MAB_0939|M.abscessus_ATCC_1997      CSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVG
MSMEG_0408|M.smegmatis_MC2_155      CSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPVG
Rv1664|M.tuberculosis_H37Rv         G-QLLGG--QHESSDD------------ESIWQLLKN-------------
Mb1692|M.bovis_AF2122/97            G-QLLGG--QHESSDD------------ESIWQLLKN-------------
MAV_3107|M.avium_104                RQQLLHD--EDPESDD------------ERIWSALRR-------------
MMAR_2473|M.marinum_M               DEQLSGG--NHEESDD------------DKIWSVLRT-------------
MUL_1655|M.ulcerans_Agy99           DEQLSGG--NHEESDD------------DKIWSVLRT-------------
MLBr_00135|M.leprae_Br4923          RTAVTAAGGALEQGPM------------DLVWSPIPLSSDGHGGGLPSV-
Mvan_1000|M.vanbaalenii_PYR-1       RLSEVTMLTESERAHY------------AVTRSPLAPTARSVPELFEMT-
TH_4458|M.thermoresistible__bu      RTNGLMAPSRTAQEVVLT--------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          RCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGA
MAB_0939|M.abscessus_ATCC_1997      RCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGA
MSMEG_0408|M.smegmatis_MC2_155      RCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDGA
Rv1664|M.tuberculosis_H37Rv         --------------------IPIHQLRRT-------------------GL
Mb1692|M.bovis_AF2122/97            --------------------IPIHQLRRT-------------------GL
MAV_3107|M.avium_104                --------------------IPLRELRRT-------------------GL
MMAR_2473|M.marinum_M               --------------------IPVRELRRS-------------------GM
MUL_1655|M.ulcerans_Agy99           --------------------IPVRELRRS-------------------GM
MLBr_00135|M.leprae_Br4923          ----VS-WADYCAGRGNDTGVVVWEFGSASAGAQAPVDSVAAVYSATHAA
Mvan_1000|M.vanbaalenii_PYR-1       ----ADRTPDAVAVRAPDRSLTYRELDAAANRLARRLRALG------VGA
TH_4458|M.thermoresistible__bu      ------------------------------------------------DA
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          SSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQA
MAB_0939|M.abscessus_ATCC_1997      SSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQA
MSMEG_0408|M.smegmatis_MC2_155      SSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQA
Rv1664|M.tuberculosis_H37Rv         LDKLLLLAGQPEE---------------------SLAGRTVSDEVIDSLS
Mb1692|M.bovis_AF2122/97            LDKLLLLAGQPEE---------------------SLAGRTVSDEVIDSLS
MAV_3107|M.avium_104                LDKLLLLAGMPET---------------------ATTDAKISDADIDSLS
MMAR_2473|M.marinum_M               LDKLLLLAGQDES---------------------PAPDAAVSDDVIDSLS
MUL_1655|M.ulcerans_Agy99           LDKLLLLAGQDER---------------------PAPDAAVSDDVIDSLS
MLBr_00135|M.leprae_Br4923          LQVLQFWFGQDRAGTLVVL---------------TRGAVGLVGEGISDLA
Mvan_1000|M.vanbaalenii_PYR-1       GAAVGLRVGRSAAMAVGMLGILK------AGGVYVPVDPTYPQDRIEHML
TH_4458|M.thermoresistible__bu      YRRAGVSPGVVQY-------------------VEAQGIGTPVGDAIEVGA
                                         .  *                                    *.   

Mflv_0405|M.gilvum_PYR-GCK          AAAAYAGARDADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQ
MAB_0939|M.abscessus_ATCC_1997      AAAAYGGSRDADRPLLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVLPQ
MSMEG_0408|M.smegmatis_MC2_155      AAAAYGAGRDADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHGVLPQ
Rv1664|M.tuberculosis_H37Rv         PEALIGLALDED---------------ENDIR------------------
Mb1692|M.bovis_AF2122/97            PEALIGLALDED---------------ENDIR------------------
MAV_3107|M.avium_104                PDALIAMALNSA---------------DDDEAE-----------------
MMAR_2473|M.marinum_M               PEALVAMALDSE---------------DDDPD------------------
MUL_1655|M.ulcerans_Agy99           PEALVAMALDSE---------------DDDPD------------------
MLBr_00135|M.leprae_Br4923          AAAVWGMVRSAQ---------------SEHSGKIVLIDTDS---------
Mvan_1000|M.vanbaalenii_PYR-1       GEAGVALLLDER---------------DVDGAEAGLCSAER---------
TH_4458|M.thermoresistible__bu      LGTVLAEDRPPDSPCLIG--------------------------------
                                      :  .                                            

Mflv_0405|M.gilvum_PYR-GCK          SLHFDTPSPHIPWDSLPVRVVDTAMPWQPNGRPRRAGVSSFGFTGTNAHV
MAB_0939|M.abscessus_ATCC_1997      SLHFDNPSPHIPWESLPVRVVDKAIPWQANGRPRRAGVSSFGFTGTNAHV
MSMEG_0408|M.smegmatis_MC2_155      SLHFENPSPHIPWDALPVRVIDEPVPWQTNGRVRRAGVSSFGFTGTNAHV
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSPEALVA
MAB_0939|M.abscessus_ATCC_1997      LIEEAPQPQATP----------DEDDASTPQSAPVSVLPLSARSPEALAA
MSMEG_0408|M.smegmatis_MC2_155      LVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLALSARSPEALVE
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LAQRYETWLTAHPEADLADVCRTAGTGRSHFEHRAALVVDSVESARIALT
MAB_0939|M.abscessus_ATCC_1997      VAQRYESWLAAHPDVDLEDVCLTAGRGRSHFEHRAALVVDSIQTAREGLL
MSMEG_0408|M.smegmatis_MC2_155      LARRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAALVVDSVERAREGLA
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ----------------AVDVAVLADLGESQLLVRCNTVHAARLSPAPQLL
Mvan_1000|M.vanbaalenii_PYR-1       ----------------LENLAAADDLAYIMYTSGSTGRPKGVAVTHGSVV
TH_4458|M.thermoresistible__bu      --------------------SVKTNIGHLEAAAGIAGLIKVALALRHRMI
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          DLAQNRLRPGVVRGEHLNHPTTAWMFTGQGSQYPGMARELFDTEPVFADT
MAB_0939|M.abscessus_ATCC_1997      ELAQNRLRPGVVRGEHTNHPTTAWLFTGQGSQYPGMARELFDAEPVFAET
MSMEG_0408|M.smegmatis_MC2_155      ALAEGRTPAGVVRGEHVHRPTTAWLFTGQGSQYPGMARELFDTQPVFAQT
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ALPVGESMWRLAADGGGTLEDLVIQPCPE---------------------
Mvan_1000|M.vanbaalenii_PYR-1       EYAETLGRELGITGEDVYLETASISFSSS---------------------
TH_4458|M.thermoresistible__bu      PPTLNFTEPNPTIEFDKLPVRVAQTLTPWPDDS-----------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTSFAQPALFAVEM
MAB_0939|M.abscessus_ATCC_1997      VTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTSFAQPALFAVEM
MSMEG_0408|M.smegmatis_MC2_155      VRQCAEAVADMLPRPLLDVLFATDRET----ADLLQHTSFAQPALFAVEM
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ----------------------------------------VQAPLQAGHM
Mvan_1000|M.vanbaalenii_PYR-1       ----------------------------------------IRQMLVPFAV
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          GLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGRLFG
MAB_0939|M.abscessus_ATCC_1997      GLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGARLIAERGRLFG
MSMEG_0408|M.smegmatis_MC2_155      GLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGARLMAERGRMFG
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          RVA-----------------------VAAVGVN-FRDVVAALG-------
Mvan_1000|M.vanbaalenii_PYR-1       GAE-----------------------VVIATTEERRDPAALLR-------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          SLPEGGRMVAVFADAKRVEQVAADFPRVSVGAYNGPNTVLSGPGEDLEQI
MAB_0939|M.abscessus_ATCC_1997      GLPAGGRMVAVFSDAKHVEQIAGEFPRVSVGAYNGPNTVLSGPGEDLEQA
MSMEG_0408|M.smegmatis_MC2_155      SLPEGGRMVAVFADAEHVEQVAGEFPRVSVGAYNGPNTVLSGPGEDLEEI
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYAAQLQFAAPTLPLVC
MAB_0939|M.abscessus_ATCC_1997      VARFQEEGIRCTWLETSHAFHSELLDPILDEFESYAAQVQFAAPTLPLVC
MSMEG_0408|M.smegmatis_MC2_155      VERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYAAQFQFAAPTLPLVC
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          NRTGAVLTGQTSLDAQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQP
MAB_0939|M.abscessus_ATCC_1997      NRTGAVLTAQTPIDGQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQP
MSMEG_0408|M.smegmatis_MC2_155      NRTGAVLTGQTPLDAQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQP
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------MYPGQAPPLGAEGAGVVIEIGPEV
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------RIGESAVTVADLVPTVVRRVIDVV
TH_4458|M.thermoresistible__bu      -----------------------GRAVAGVSAFGFGGTNAHVVLAEAPQV
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VLTGAAVQVWPEHLAAPRAIASLRKGVADRRQIADALAAAYIGGHKPDFA
MAB_0939|M.abscessus_ATCC_1997      VLTGAAVQVWPEHLAPPRAIVSLRKGVEDRRQIADALASAYVSGHRPNFA
MSMEG_0408|M.smegmatis_MC2_155      VLTGAAVQVWPEHMAAPRAVASLRKGVADRRQIADALASAYVGGHRPDFA
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          TGV-----------AVGDAVMGFLGGAGPLAVVHQQLITQMPQGWSLAEA
Mvan_1000|M.vanbaalenii_PYR-1       AAA-----------DAGQRTASRRNRLRLLLTASEPLRAGVVRAWREQLG
TH_4458|M.thermoresistible__bu      RAAATADDHADGFVEILPLSARSQAALDALAERYESALTGGVPPADLCHT
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ALHEQRGVRLELPTYPFQRRRFWPKSAGMAIDGRVGASAGSGILGSGKDL
MAB_0939|M.abscessus_ATCC_1997      ALQRHPRRTVELPTYPFQRRRFWPKSSGTAIEG--GGGLPSGILGRGEDL
MSMEG_0408|M.smegmatis_MC2_155      AVHRQPRRPVELPTYPFQRRRFWPKASSIAVDG---GTAASGILGSGKDL
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          AAVP----------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       GGAS----------------------------------------------
TH_4458|M.thermoresistible__bu      AGAR----------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ASGDSVYTSRLSVKTQPWLSDHVIYGTVVVPGATYAAMALAAVGTPAHAK
MAB_0939|M.abscessus_ATCC_1997      ASGDSVYISRLSVRSQPWLSDHVIYGTVVVPGATYAAMALAAVGTPARAK
MSMEG_0408|M.smegmatis_MC2_155      ASGDTIYTSRLSVKSQPWLADHVIYGTVVVPGATYAAMALAAVGTPARLK
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          -----------VVFLT---ALFGLADLAGIRAGESVLIHAGTGGVGMAAV
Mvan_1000|M.vanbaalenii_PYR-1       -----------WINMYGQTETTGIVSLHPVGEPDGDAQSIVPIGRPRANV
TH_4458|M.thermoresistible__bu      -----------RAHHDHRLAVVGASRAELIGALAAYRRGEPHPGVFTGRS
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          DVFFYEPIILPEKSSREVQLTVHPSVDGE-SKFQVHSRPYGERGAEWALN
MAB_0939|M.abscessus_ATCC_1997      DVFFYEPIILPEKSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSLN
MSMEG_0408|M.smegmatis_MC2_155      DVFFYEPIILPEKASREVQLTLHPADGGSVLSFQIHSRPYGERGADWSLN
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          QFARHWGVEIFVTASRGKWDTLRDM-------------------------
Mvan_1000|M.vanbaalenii_PYR-1       GMYVLDRLMRPVPPGVGGALFIAGP-------------------------
TH_4458|M.thermoresistible__bu      QSGHRSGVVFVFSDEGSQWR------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AEGVVASGVGD---SPAAAGDLEDPVDEAIERLNRMRPQELFETFADLEL
MAB_0939|M.abscessus_ATCC_1997      AEGTVVTGIGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLEL
MSMEG_0408|M.smegmatis_MC2_155      AEGTVDTAGSD---PDAAADEQSDPVDEVIERLERMRPQDLFETFADLEL
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AWGPTWSGSLKSLWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGV
MAB_0939|M.abscessus_ATCC_1997      AWGPTWSGSLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGV
MSMEG_0408|M.smegmatis_MC2_155      AWGPTWSGSLKSLWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGV
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AFPAFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDS
MAB_0939|M.abscessus_ATCC_1997      AFPAFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDS
MSMEG_0408|M.smegmatis_MC2_155      AFPAFPALLAAEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDS
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ETQVFDLEYLDRDGRHLGGVREFTVKRAPREALLRGLGGDATRLLYTLGW
MAB_0939|M.abscessus_ATCC_1997      ETQVFDLDYLDRDGRHLGGIREFTVKRAPREALLRGLGGDATRLLYTLGW
MSMEG_0408|M.smegmatis_MC2_155      ETQVFELEFVDLGGRALGGIREFTVKRAPREALLRGLGGDATRLLYTLGW
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          -------------------------------GFDDDHIGDSRTLEFEE--
Mvan_1000|M.vanbaalenii_PYR-1       -------------------------------ALAREYVGDPTLTAQKY--
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          HEVPVP----ESGDGAAPQGTWLIGGFDELAVSVPGCIPADR-TNPESLR
MAB_0939|M.abscessus_ATCC_1997      HEVAVPPVAGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRETDPELLG
MSMEG_0408|M.smegmatis_MC2_155      HEVPPP------PSADDAVGTWLIAGFDELAAKVPGCVPIDRNTDLQVLG
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          QLLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVH
MAB_0939|M.abscessus_ATCC_1997      EVLVAAKERGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVH
MSMEG_0408|M.smegmatis_MC2_155      EVLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLSAVH
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          TVQ---GGEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEE
MAB_0939|M.abscessus_ATCC_1997      TVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEE
MSMEG_0408|M.smegmatis_MC2_155      AAQ---GPSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEE
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ---------------------KFLAVTDGRGVDVVLDSLAG---------
Mvan_1000|M.vanbaalenii_PYR-1       ---------------------VPAPWNPAERLYVSGDMVRLGWDGTIEYR
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          PALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWS
MAB_0939|M.abscessus_ATCC_1997      PALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWS
MSMEG_0408|M.smegmatis_MC2_155      PALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWA
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          -------DFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFD
Mvan_1000|M.vanbaalenii_PYR-1       GRADRQVKIRGLRVEPAEIDRVLLEHPGVREAVTVVREANADGAALVAYF
TH_4458|M.thermoresistible__bu      -----------GMAQRLYAEDQVFRTALAECDRALRRHMEISPLSELLAD
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          RSGHLTVPRGGDYVLAPTERGAIDNLRLTDSEVPPPAEGYVQVRVEAAGL
MAB_0939|M.abscessus_ATCC_1997      RTGHLTVPRGSDYVLAPTERGAIDNLRITEKEVPAPDEGYVQVRVEAAGL
MSMEG_0408|M.smegmatis_MC2_155      RSGHLTLPRGGDFVLAPTERGAIDNLRLTETDVPEPDEGYVQVRVEAAGL
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          LSEAGPVRMQ---------------------------EMLCEVR------
Mvan_1000|M.vanbaalenii_PYR-1       TTGDTPVPVG---------------------------ELRAHARRQLPDH
TH_4458|M.thermoresistible__bu      PSHSR---------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          NFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGA
MAB_0939|M.abscessus_ATCC_1997      NFRDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGA
MSMEG_0408|M.smegmatis_MC2_155      NFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGA
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ----ELFDTQVLHRLPVTSWDVRCAPAAFR--------------------
Mvan_1000|M.vanbaalenii_PYR-1       MVPSAFTALEQLPLTPNGKLDRTALPEVTI--------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          FASRFNVPGQFLAPIPDGVSAVEAATIPAAALTVRLSFDWAQVKSGDKVL
MAB_0939|M.abscessus_ATCC_1997      FGSRFNVPAQFLAPIPDGISGVEAATIPAAALTVRLSFDWAQLKPGDKVL
MSMEG_0408|M.smegmatis_MC2_155      FASRFNVPAQFLAPIPDGIGAVEAATIPAAALTVRLAFDWAQLKPGDKVL
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ---------------------FMSQARHIGKVVLTMPSALADGLAEGTVL
Mvan_1000|M.vanbaalenii_PYR-1       ---------------------TRDQEIEYVPPRSGVEQSLAEIWSDTLQL
TH_4458|M.thermoresistible__bu      ----------------------MDEVTIASPALFAVQVALAALWQSWG--
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          IHAASGGVGLAAVQMAQQCGAEVYATASTFKRATLRKLGVKHVYDSRTTD
MAB_0939|M.abscessus_ATCC_1997      IHAASGGVGLAAIQMAQQFGAEVFATASTFKRATLRKLGVKYVYDSRTTD
MSMEG_0408|M.smegmatis_MC2_155      IHAASGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLGVKYVYDSRTTD
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ITGASG------------------AIGGVLARHMVSAYGVRHLVLA----
Mvan_1000|M.vanbaalenii_PYR-1       EQIGAG------------------DNFFELGGHSLLAAQVRSRIHQ----
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          FAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWT
MAB_0939|M.abscessus_ATCC_1997      FADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWT
MSMEG_0408|M.smegmatis_MC2_155      FADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWS
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          ----------------SRRGDRAEGAVELAAELVGAGAKIQ-VVACDVAD
Mvan_1000|M.vanbaalenii_PYR-1       ----------------LLGVELPLEALFEDQTLSDLAHRIEGDTGVDTSE
TH_4458|M.thermoresistible__bu      ---------------------VEPAAVIGHRMGEVAAAHVAGVLGLDDAA
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VEQMAAARPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWTPLPA
MAB_0939|M.abscessus_ATCC_1997      TEQMAQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWTPLPA
MSMEG_0408|M.smegmatis_MC2_155      HEQMAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWTPLPA
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          NDAVRGLFAQLSREFPPVRGVIHA---------AGVLDDGAITSLTPDRV
Mvan_1000|M.vanbaalenii_PYR-1       APLLRPVARTGPPPLSYAQELMWR---------NECDDPGSPAHWIDVSI
TH_4458|M.thermoresistible__bu      ALLCGRTRLSRLASTGAVR----------------EGLDGLLANLRPDDP
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          EVYPLTEARAAFRRMQQARHIGKIVVQIPNPLQPQPDRSYLITGGLGAIG
MAB_0939|M.abscessus_ATCC_1997      EIYPLTEARTAFRRMQQARHIGKIVCQMPNPLAPRPDRTYLITGGLGAIG
MSMEG_0408|M.smegmatis_MC2_155      EIYPITEARSAFRRMQQARHIGKIVLQVPKPLQPQQDRSYLITGGLGAIG
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          DTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAANAF
Mvan_1000|M.vanbaalenii_PYR-1       RITGPLDPDLVVRGIQAATHRHELLRTVFRPSGASAAQVILDSYTPEVPI
TH_4458|M.thermoresistible__bu      RIPLYSTVTGDAVTGRGFGAAHWMENLHSPVRFSAAVRRLLGRGHDAFLE
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADIADRTKARLHVFTADVG
MAB_0939|M.abscessus_ATCC_1997      LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEITERSKTRIHVFTADVG
MSMEG_0408|M.smegmatis_MC2_155      LHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCRIHTYAADVG
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          LDGLAAYRQAAGLAGTSLAWG-----------------------LWEQPG
Mvan_1000|M.vanbaalenii_PYR-1       FDGAAALQHDVWPDQPDLATCPPLRAELCRIDDGNHILRLRVHRILADGY
TH_4458|M.thermoresistible__bu      ISAHPMLLSAVQEDAADLGRSCTTLVSMRRGECGRDVLMTSLAALYASGH
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVERFRTALAPKA
MAB_0939|M.abscessus_ATCC_1997      AESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVERFRTTLAPKA
MSMEG_0408|M.smegmatis_MC2_155      DEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRTTLAPKA
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          GMNAHLSSRDLARISRSGLAPMNPAQALELFDAALVIDHPFMVTALLDR-
Mvan_1000|M.vanbaalenii_PYR-1       TMRLLLSEIGGLVASSAGLPDFPLLDGDLHYADYAIWERSWLTGAALQRR
TH_4458|M.thermoresistible__bu      AVDWARVHPHGSHCTAAPTYPWQRQRFWLDIDRCDTGDGAGTGGTAERTV
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          FGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLDGLVAQR
MAB_0939|M.abscessus_ATCC_1997      FGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLDGLIAQR
MSMEG_0408|M.smegmatis_MC2_155      YGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLDGLVAKR
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          -AALDAQAQAG-------ALPPLFSRLVRRSRRRQIEDPGDATQSKLALV
Mvan_1000|M.vanbaalenii_PYR-1       IDHFRREFAVG-------ELPPALPTDHPRTGRSRRAAGQLDFEFPAEVA
TH_4458|M.thermoresistible__bu      VPAPLPAPSAS-------AAPTVDEVLLCADQRERRELLESYLRDRVAAE
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          RAQGLPATGVNFGPWARGGMASSEAAAANISAQGLIPLEPSAALTAMAEV
MAB_0939|M.abscessus_ATCC_1997      RAQGLPATGINFGPWGQGGMASSEAATANISAQGLIPLDPSAALAALAEV
MSMEG_0408|M.smegmatis_MC2_155      RAQGLVATGINFGPWGQGGMASSEAATANITAQGLIPLDPSAALHALAEV
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          QRLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDP--------NTKFQ
Mvan_1000|M.vanbaalenii_PYR-1       AAARALAVREHASLYTVLLAGFAAALGGYAGRRTVVLGSPVTRRNDPVTQ
TH_4458|M.thermoresistible__bu      LGVLPPLLDVAAPLSTLGIDSLTAAELRARVERDLGIVIPVAQLLNGPSV
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VANGTAQATVLKANWQRAAKVLGSSRPPILDLVLPSAVGEITGDSELLKQ
MAB_0939|M.abscessus_ATCC_1997      VANGTGQATILKANWQRAAKVLGSSRPPILDLVLPSAVGEVTGDSELLKQ
MSMEG_0408|M.smegmatis_MC2_155      IANGSGQATVLKANWQRAAKVLGSARPPILDLVLPSAAGEATGDSELLKQ
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          DLGFDSLTAVELRNRLKSATGLTLPPTVIFDHPTPTAVAEYVAQQMLKSR
Mvan_1000|M.vanbaalenii_PYR-1       LMLGPFMNTVPLRIDLPEGGGLAAMVQNMKTTVLGALSHQDAPSQHVIAA
TH_4458|M.thermoresistible__bu      SDLAEWISTTMVGFGSTTPEPESAGVPGRSRPPDGAVASGSGDGGRWIEL
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LQEIPVPQRAGFVTEFLQKEVQNFLRLAQPPAATSRFLDLGTDSLMAIEL
MAB_0939|M.abscessus_ATCC_1997      LMEIPVPQRAGFVTEFLQREVQNFLRLAQPPAATSRFLDLGTDSLMAIEL
MSMEG_0408|M.smegmatis_MC2_155      LMEIPIPQRAGFVTEFLQREVQNFLRLASPPAASSRFLDLGTDSLMAIEL
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          PAESGDETSQAVEPKVEEVSVHA---------------------------
Mvan_1000|M.vanbaalenii_PYR-1       LAAEHGPSAAAIGETVFLMDDPVPGEFAAGGFRLTRVPPERVIARRELTA
TH_4458|M.thermoresistible__bu      LNQMPEVSDDTVDELLRQLLAAGENHDDTQLH------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          RNRLHSQFGGAFTINATAVFDYPTIGGLAEYLVAQLPDAETPQAAP----
MAB_0939|M.abscessus_ATCC_1997      RNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAV
MSMEG_0408|M.smegmatis_MC2_155      RNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA-----
Rv1664|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1692|M.bovis_AF2122/97            --------------------------------------------------
MAV_3107|M.avium_104                --------------------------------------------------
MMAR_2473|M.marinum_M               --------------------------------------------------
MUL_1655|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
Mvan_1000|M.vanbaalenii_PYR-1       AMSTRNRQITGTLTYDSTLFDHPSIECIVAGFIGAVSALHVDCA------
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ---QSESEPGPDVTE--------
MAB_0939|M.abscessus_ATCC_1997      ESAEAESGAGPAAASDAVSELKE
MSMEG_0408|M.smegmatis_MC2_155      -----------------------
Rv1664|M.tuberculosis_H37Rv         -----------------------
Mb1692|M.bovis_AF2122/97            -----------------------
MAV_3107|M.avium_104                -----------------------
MMAR_2473|M.marinum_M               -----------------------
MUL_1655|M.ulcerans_Agy99           -----------------------
MLBr_00135|M.leprae_Br4923          -----------------------
Mvan_1000|M.vanbaalenii_PYR-1       -----------------------
TH_4458|M.thermoresistible__bu      -----------------------