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VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMDPRQRLALELT WELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTI DSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDG GGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAH GTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAA IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGA GVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLE STEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGG VMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDP MVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGP GAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQ MAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAG QPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1664 | pks9 | - | 100% (1017) | Probable polyketide synthase pks9 |
M. tuberculosis H37Rv | Rv0405 | pks6 | 0.0 | 48.34% (995) | membrane bound polyketide synthase |
M. tuberculosis H37Rv | Rv1662 | pks8 | 0.0 | 49.03% (924) | polyketide synthase pks8 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1692 | pks9 | 0.0 | 99.80% (1017) | polyketide synthase pks9 |
M. gilvum PYR-GCK | Mflv_0405 | - | 1e-155 | 39.50% (914) | beta-ketoacyl synthase |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 48.14% (889) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 1e-151 | 37.14% (902) | polyketide synthase |
M. marinum M | MMAR_2473 | pks9 | 0.0 | 63.65% (1018) | polyketide synthase Pks9 |
M. avium 104 | MAV_3107 | - | 0.0 | 63.89% (1044) | polyketide synthase |
M. smegmatis MC2 155 | MSMEG_0408 | - | 1e-155 | 39.08% (888) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4458 | - | 1e-142 | 36.53% (1002) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
M. ulcerans Agy99 | MUL_1655 | pks9 | 0.0 | 63.06% (1018) | polyketide synthase Pks9 |
M. vanbaalenii PYR-1 | Mvan_1000 | - | 1e-167 | 39.06% (1001) | amino acid adenylation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK ------------------------------MGSAAHQGESAHRFAIVGYA MAB_0939|M.abscessus_ATCC_1997 ------------------------------MDSAENPIESTPRFAIIGYA MSMEG_0408|M.smegmatis_MC2_155 ------------------------------MVSAEHPIEPTPSFAIIGYA Rv1664|M.tuberculosis_H37Rv --------------------------------------MQPTGIAIIGLA Mb1692|M.bovis_AF2122/97 --------------------------------------MQPTGIAIIGLA MAV_3107|M.avium_104 --------------------------------------MPPTDVAIIGMA MMAR_2473|M.marinum_M ----------------------MSRATSLRRQHGDGDQEFASAVAIIGVA MUL_1655|M.ulcerans_Agy99 ---------------------MMSRATSLRRQHGDGDQEFASAVAIIGVA MLBr_00135|M.leprae_Br4923 MTASVEGADQKSEKLISYLKKVVVELDETRARLREYEQRATEPVAVVGIG Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------MTGQSGFAVVGYA TH_4458|M.thermoresistible__bu -------------------------------LLSLLRQRSERYGDKIAFD :. Mflv_0405|M.gilvum_PYR-GCK GRFPG-ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVV MAB_0939|M.abscessus_ATCC_1997 ARFPG-AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVV MSMEG_0408|M.smegmatis_MC2_155 ARFPG-AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVV Rv1664|M.tuberculosis_H37Rv CRFPT-VVSPGDLWDLLRDGREAA-------------------------- Mb1692|M.bovis_AF2122/97 CRFPT-VVSPGDLWDLLRDGREAT-------------------------- MAV_3107|M.avium_104 CRFPG-APDPGSFWRLLRDGREVT-------------------------- MMAR_2473|M.marinum_M CRFPG-AANPGEFWELVSEGHEVA-------------------------- MUL_1655|M.ulcerans_Agy99 CRIPG-AANPGEFWELVSEGHEVA-------------------------- MLBr_00135|M.leprae_Br4923 CRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTY Mvan_1000|M.vanbaalenii_PYR-1 VRFPG-AADAREFWDVLAEGRDAVSEVPADR-WDVDEFFDADPDAAGKMV TH_4458|M.thermoresistible__bu YCTGEQEHSRLTYQELDIRARAIAAHLQDQG-------------VAGERV . : : Mflv_0405|M.gilvum_PYR-GCK TRRAGFVDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAP MAB_0939|M.abscessus_ATCC_1997 TRRAGFVEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAP MSMEG_0408|M.smegmatis_MC2_155 TRRAGFVDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAP Rv1664|M.tuberculosis_H37Rv ----GSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVP Mb1692|M.bovis_AF2122/97 ----GSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVP MAV_3107|M.avium_104 ----RFAGEAAEFDADFFNLSPREAAAMDPRQRLALELAWELLEDAFIVA MMAR_2473|M.marinum_M ----KPIDHVGDFDAEFFNVSPREAAAMDPRQRLALELAWELFEDARIVA MUL_1655|M.ulcerans_Agy99 ----KPIDHVGDFDAEFFNVSPREATAMDPRQRLALELAWELFEDARIVA MLBr_00135|M.leprae_Br4923 TRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDP Mvan_1000|M.vanbaalenii_PYR-1 SRRAGFVDDVAGFDAPFFGVSAREAMFMDPQHRLVLETAWSAVEHAGIAP TH_4458|M.thermoresistible__bu LVLCPSGLDFITAMFGCFYVGAVAVPVHPPVHNRLLSRVASIVADVRATS . * :.. . * :. :. . . Mflv_0405|M.gilvum_PYR-GCK SELANTNTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRIS MAB_0939|M.abscessus_ATCC_1997 TDLAETNSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRIS MSMEG_0408|M.smegmatis_MC2_155 TSLANSNTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRIS Rv1664|M.tuberculosis_H37Rv ETLRGQPIAVYLGAMNDDYA-VLTL--AADRVDHHAFAGTSRAIIANRVS Mb1692|M.bovis_AF2122/97 ETLRGQPIAVYLGAMNDDYA-VLTL--AADRVDHHAFAGTSRAIIANRVS MAV_3107|M.avium_104 ETLRGEAVSVYLGAMTDDYA-ALTLRDVPDNVDHHTFTGVSRGMIANRIS MMAR_2473|M.marinum_M ESVRGEPIAVYLGAMNDDYA-LLTLDQAPDKLDHYSFAGASRGMIANRVS MUL_1655|M.ulcerans_Agy99 ESVRGEPIAVYLGAMNDDYA-LLTLDQAPDKLDHYSFAGASRGMIANRVS MLBr_00135|M.leprae_Br4923 LSLRGSATGVFTGIFAPSYG-SRDT----GGLQGYGLTGTAVSVASGRVS Mvan_1000|M.vanbaalenii_PYR-1 EALAGTRTGVFLGLSTHEFLGMLIAHTGYEDVDIYSGTGTSPAAAAGRVS TH_4458|M.thermoresistible__bu VLTTAATRADLKEILDGLHDGDPLRWLAVDTIEADDETSWTPTTVDTDSV . . :: . : Mflv_0405|M.gilvum_PYR-GCK YRLGLQGPAVAVDTACSSSLVAIHQACQALR-LGECDLALAGGANVILTP MAB_0939|M.abscessus_ATCC_1997 YRLGLQGPSVAVDTACSSSLVAIHQACQALQ-LGECDLALAGGANVLLTP MSMEG_0408|M.smegmatis_MC2_155 YRLGLQGPAVAVDTACSSSLVAIHQACQALR-LNECDLALAGGANVLLTP Rv1664|M.tuberculosis_H37Rv FAFGLRGPSVTIDSGQSSSLVAVHLACESVR-TGEAPLAIAGGVHLNLAR Mb1692|M.bovis_AF2122/97 FAFGLRGPSVTIDSGQSSSLVAVHLACESVR-TGEAPLAIAGGVHLNLAR MAV_3107|M.avium_104 YLLGLRGASMTVDSGQSSSLVAVHLGCESVR-SGQAPLAIAGGVHLNLAD MMAR_2473|M.marinum_M YGFALHGPSMTVDCGQSSSLVAVHLAREYLRGAGDATMAIAGGIHLNLAS MUL_1655|M.ulcerans_Agy99 SGFALHGPSMTVDCGQSSSLVAVHLAPGYLRGAGDATMAIAGGIHLNLAS MLBr_00135|M.leprae_Br4923 YVLGLEGPAVSVDTACSSSLVAIHWAMSSLR-SGECDLALAGGVTVMGLP Mvan_1000|M.vanbaalenii_PYR-1 FRMGLQGPAVAVDTACSSSLVAVHQACQALR-DGDCDTALVGGVNVILTP TH_4458|M.thermoresistible__bu AFVQYTSGSTSTPKGVVLTHHNLLANLESISRDAGQGDEARVVSWLPLHH . . : : . : : : : Mflv_0405|M.gilvum_PYR-GCK ATMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDG- MAB_0939|M.abscessus_ATCC_1997 ATMITFSHAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDG- MSMEG_0408|M.smegmatis_MC2_155 ATMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDG- Rv1664|M.tuberculosis_H37Rv ETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDG- Mb1692|M.bovis_AF2122/97 ETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDG- MAV_3107|M.avium_104 EIALLEREFGAVSVSGHTYAFDRRADGYVRGEGGGLVLLKPLAAARRDG- MMAR_2473|M.marinum_M ETGRLETEFGAVSASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDG- MUL_1655|M.ulcerans_Agy99 ETGRLETEFGAVSASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDG- MLBr_00135|M.leprae_Br4923 SIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLG- Mvan_1000|M.vanbaalenii_PYR-1 VPMINLTRARMLAPDGRCKTFDAAADGYVRGEGCGVVVLKRTGDALRDG- TH_4458|M.thermoresistible__bu DMGLIGGIFGVVHFGG--TAYLMPPSSFIQRPMSWLEAISWHGANISVGP : .* :: ... : :. * Mflv_0405|M.gilvum_PYR-GCK --------DRIRAVIRGSAINQDGASG-GLTVPNGVAQQRVIGDALSRAG MAB_0939|M.abscessus_ATCC_1997 --------DRIRAVIRGSAINQDGASG-GLTVPNGVAQQRVIADALKRAG MSMEG_0408|M.smegmatis_MC2_155 --------DRIRAVIRGSAINQDGASG-GLTVPNGVAQQRVIADALKRAG Rv1664|M.tuberculosis_H37Rv --------DRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAG Mb1692|M.bovis_AF2122/97 --------DRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAG MAV_3107|M.avium_104 --------DRIHAVIRATAVGNAGHGAPAQTLPSAAAEADVIGRALAEAG MMAR_2473|M.marinum_M --------NRIRAVILGAAVGSAGHTAGGLAAPSAAAEADVMRRAMASAG MUL_1655|M.ulcerans_Agy99 --------NSIRAVILGEAVGSAGHTAGGLAAPSAAAEADVMRRAMASAG MLBr_00135|M.leprae_Br4923 --------HTVLAVVRGSAVNQDGASN-GLTAPNGLAQQRVIQAALTNAG Mvan_1000|M.vanbaalenii_PYR-1 --------DRIRAVIRGSAVNQDGASG-GLTVPNGVAQQHVIADALRRAG TH_4458|M.thermoresistible__bu NFGYQLCVERSTPEERATLDLSTWVRAYCGAEPVRAATMRRFTEAFAPAG . . . . : * . : *: ** Mflv_0405|M.gilvum_PYR-GCK LAPGDVD--YLEAHGTGTSLGDPIEAQAAGAALGPGREPQRPLLIGSAKT MAB_0939|M.abscessus_ATCC_1997 VAPSEVG--YLEAHGTGTSLGDPIEAQAAGAAYGIGRETNDPLLIGSAKT MSMEG_0408|M.smegmatis_MC2_155 LRPADVG--YLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLIGSAKT Rv1664|M.tuberculosis_H37Rv VDCHQVH--YVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKT Mb1692|M.bovis_AF2122/97 VDCHQVH--YVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKT MAV_3107|M.avium_104 LGGADID--YVEAHGTGTRVGDAVETQALGRIFAERS--HHPVSVGSVKT MMAR_2473|M.marinum_M VDPNQID--YIEAHGTGTRIGDTTEAQALSEVFATR---ETPVWLGSVKS MUL_1655|M.ulcerans_Agy99 VDPNQID--YIEAHGTGTRIGDTTEAQALSEVFATR---ETPVWLGSVKS MLBr_00135|M.leprae_Br4923 LSSADVD--VVEAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKS Mvan_1000|M.vanbaalenii_PYR-1 LGGGEVD--YLEAHGTGTSLGDPIEVQAAAAAFGDGRDPDRPLLIGSVKT TH_4458|M.thermoresistible__bu FRADAFHPVYGLAEATLFVSGRPENVLPTVRSLDNAALREHRVVPAAADD . . *..* * . :. . : .: . Mflv_0405|M.gilvum_PYR-GCK NIGHLEAAAGIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVK MAB_0939|M.abscessus_ATCC_1997 NIGHLEAAAGIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVR MSMEG_0408|M.smegmatis_MC2_155 NIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLPIEVVR Rv1664|M.tuberculosis_H37Rv NIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVG--AAIDLDSLGLRVDT Mb1692|M.bovis_AF2122/97 NIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVG--APIDLDSLGLRVDT MAV_3107|M.avium_104 NIGHAASAAGIAGLLKAVLAIEHAAIPPNLHFERPDPDIDLNRLGLRVNT MMAR_2473|M.marinum_M NIGHTGAAAGAAGLIKTVLSLENGAIPASLNYVGDSAGTDMESHGLHVST MUL_1655|M.ulcerans_Agy99 NIGHTGAAAGAAGLIKTVLSLENGAIPASLNFVGDSAGTDMESHGLHVST MLBr_00135|M.leprae_Br4923 NMGHTQAAAGVAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLT Mvan_1000|M.vanbaalenii_PYR-1 NIGHLEAASGIAGLIKVVLSLEHETLPVHLHLRRPSPHIPWERLPVRVVA TH_4458|M.thermoresistible__bu ANAAAVVGCGPAAYGEEIVIVDPATRREFPPDVVGEIWVAGENVAQGYLG . ..* *. : : : Mflv_0405|M.gilvum_PYR-GCK ESIPWRRGQRGGRPRIAGVSSFGFAGTNAHVILEEAPLAA--EPAQES-- MAB_0939|M.abscessus_ATCC_1997 EARPWGR---NGRPRIAGVSSFGFAGTNAHVILEEAPVVS--RDAVEPPA MSMEG_0408|M.smegmatis_MC2_155 ETVPWQR---NGKPRIAGVSSFGFAGTNAHVILEEAPAVG--TPATTEP- Rv1664|M.tuberculosis_H37Rv ALTPWPV---ADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAA Mb1692|M.bovis_AF2122/97 ALTPWPV---ADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAA MAV_3107|M.avium_104 ALAPWPD---RGGPRRAGVSSFGMGGTNAHVIVEQDAAQ-----QNPTPA MMAR_2473|M.marinum_M TLTPWPR---GAGPRRAGVSSFGMGGTNAHVIVQQAPIP-----QEAVAD MUL_1655|M.ulcerans_Agy99 TLTPWPR---GAGPRRAGVSSFGMGGTNAHVIVQQAPIP-----QEAVAD MLBr_00135|M.leprae_Br4923 EARDWSV---EGRPRRAGVSSFGISGTNAHVILEEAPTP---VEASYSTA Mvan_1000|M.vanbaalenii_PYR-1 EATPWQR---NDRPRIAGVSSFGFSGTNAHVLLEEAPVAS----PTEEPD TH_4458|M.thermoresistible__bu KPSESAET-FAAHLADSGRGPFLRTGDYGFLLDGELFVTG----RLKDLI :* ..* * ..:: : Mflv_0405|M.gilvum_PYR-GCK -VDDGRFTLLPLSARTPAALMAVADRYRDWLVANPDATLADLCFTAGTAR MAB_0939|M.abscessus_ATCC_1997 PAGGRKFSILPLSARTPAALAQLADKYRAWLNAHPEAALADLCFTAGVGR MSMEG_0408|M.smegmatis_MC2_155 VEDPRRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAGTAR Rv1664|M.tuberculosis_H37Rv GSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR Mb1692|M.bovis_AF2122/97 GSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR MAV_3107|M.avium_104 SAPADVALPWVLSARSERALALQAQRLSAHLAERPQASPLDVGWSLVSAR MMAR_2473|M.marinum_M PDGTEATVPWLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTR MUL_1655|M.ulcerans_Agy99 PDGTEATVPWLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTR MLBr_00135|M.leprae_Br4923 DQQRLSVVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALA-AR Mvan_1000|M.vanbaalenii_PYR-1 EAPHRRYHLLPLSARTPEALVRLASRHLAYLEDDPDATIVDICAAAGAGR TH_4458|M.thermoresistible__bu IIRGRNYHPNDIEATVQEVHPALMSGRGAAFAVSP-----DPSGTEQLVI : . . . * : Mflv_0405|M.gilvum_PYR-GCK SHLEHRAALVVNTREAALDLLGALADDRPAPGLVRGESHDTPKTAWLFTG MAB_0939|M.abscessus_ATCC_1997 AHLEHRAALVVNTREAAVELLSAVADDRPAPGLGRGESHDTPKTAWLFTG MSMEG_0408|M.smegmatis_MC2_155 AHLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWLFTG Rv1664|M.tuberculosis_H37Rv SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG Mb1692|M.bovis_AF2122/97 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG MAV_3107|M.avium_104 AVFEHRAVLVGCERGVLATGLAGVASGRPDAATVVGRARATGKTVLVFPG MMAR_2473|M.marinum_M SVFEHRAVLVGGDRGGFMAGLAALASGEPGVNLVAGRAGSGGKTVLVFPG MUL_1655|M.ulcerans_Agy99 SVFEHRAVLVGGDRGGFMAGLAALASGEPGVNLVAGRAGSGGKTVLVFPG MLBr_00135|M.leprae_Br4923 SVFEHRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPG Mvan_1000|M.vanbaalenii_PYR-1 SHFEHRAALVVDSRPRARRLLRAIHEERPAPGLVRGVCSDRPKTAWLFGG TH_4458|M.thermoresistible__bu VQEVDRGRLGEVDTDELIAAIRTAVTSQHDIGVHTVVLVDPLRIPTTSSG .*. : : . : * Mflv_0405|M.gilvum_PYR-GCK QGSQYPGMSRELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLD MAB_0939|M.abscessus_ATCC_1997 QGSQYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD---G MSMEG_0408|M.smegmatis_MC2_155 QGSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDAD-ELD Rv1664|M.tuberculosis_H37Rv QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG------ Mb1692|M.bovis_AF2122/97 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG------ MAV_3107|M.avium_104 QGSQTLGMGRQLYERFVVFARALDEAVAVVDEHSRLSVREVMWG------ MMAR_2473|M.marinum_M QGAQWLGMGRDLYGRFPAFAKAFDTVADALDEHLRLPLREVIWG------ MUL_1655|M.ulcerans_Agy99 QGAQWLGMGRDLYGRFPAFAKAFDTVADALDEHLRLPLREVIWG------ MLBr_00135|M.leprae_Br4923 QGAQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWG------ Mvan_1000|M.vanbaalenii_PYR-1 QGNQFPGMAREVFDHEPVFAQTLRRCGEVLDGLLPRPLLEVIFDTG---- TH_4458|M.thermoresistible__bu KIRRRTCRQRFLDGELDAFAEWRLATPRPAQPVPAADEQADEQAG----- : : * : ** Mflv_0405|M.gilvum_PYR-GCK TDSNETLRHTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAAC MAB_0939|M.abscessus_ATCC_1997 PEAEETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAAC MSMEG_0408|M.smegmatis_MC2_155 GDTESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSAAC Rv1664|M.tuberculosis_H37Rv -ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAY Mb1692|M.bovis_AF2122/97 -ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAY MAV_3107|M.avium_104 -ADPELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAAC MMAR_2473|M.marinum_M -ADASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEISAAH MUL_1655|M.ulcerans_Agy99 -ADASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEISAAH MLBr_00135|M.leprae_Br4923 -ADAGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAY Mvan_1000|M.vanbaalenii_PYR-1 PEAEHNLRNTAFAQPALFAVEMGMARLWRSWGVEPDVVLGHSVGQYAAAC TH_4458|M.thermoresistible__bu --AGPGAGPGADEIRAWFVAQLAGELGLSPDDIDTGQPFAYYG--LDSVR * *. ::. .. .. ..: :. Mflv_0405|M.gilvum_PYR-GCK VAGVLSLRDGARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEYPAL MAB_0939|M.abscessus_ATCC_1997 VAEVFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEFPSL MSMEG_0408|M.smegmatis_MC2_155 VAGVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEYPSL Rv1664|M.tuberculosis_H37Rv VAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEG--V Mb1692|M.bovis_AF2122/97 VAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEG--V MAV_3107|M.avium_104 VAGVLSLRDAARLVAARGALMAALPPGGVMVAVTATEAQVAPLVGGG--V MMAR_2473|M.marinum_M VAGVLSLTDAARLVSARGRLMAQLPPGGVMVAVAASAAQVAPMLEEG--V MUL_1655|M.ulcerans_Agy99 VAGVLSLTDAARLVSARGRLMAQLPPGGVMVAVAASAAQVAPMLQEG--V MLBr_00135|M.leprae_Br4923 VAGVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEG--V Mvan_1000|M.vanbaalenii_PYR-1 VAGVFGLDEGARLIAERGRLFANLPSGGRMLAVFADPDRVERCTAEHSRL TH_4458|M.thermoresistible__bu AIQLMTALEAWSGIKVAPTLAYDHPTIDLAAEHLAGLTHTATSTAADAGV . : :. : * *. . : .. : Mflv_0405|M.gilvum_PYR-GCK SVAAYNGAN-TVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALLDP MAB_0939|M.abscessus_ATCC_1997 SVAAYNGAN-TVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLDP MSMEG_0408|M.smegmatis_MC2_155 SVAAYNGAN-TVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLDP Rv1664|M.tuberculosis_H37Rv CIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDP Mb1692|M.bovis_AF2122/97 CIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDP MAV_3107|M.avium_104 SIAAVNGPDAVVLSGEQEAVSAVAERLAGSGARVHRLAVSHAFHSALMEP MMAR_2473|M.marinum_M SIAAVNGPDSVVISGPEAATAVVADRLTGQGCRAHRLAVSHAFHSALMEP MUL_1655|M.ulcerans_Agy99 SIAAVNGPDSVVISGPEAATAVVADRLTGQGCRAHRLAVSHAFHSALMEP MLBr_00135|M.leprae_Br4923 GIAAINAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEP Mvan_1000|M.vanbaalenii_PYR-1 SVAAYNGAN-TVLSGPAPDLEQVHAELTAAGSRCDWLDTSHAFHSALVDP TH_4458|M.thermoresistible__bu STGAGRRPE----HGPAPDRADEPIAIIGIGCRFPGADGPAAYWRLLRE- .* . .: * : . * * . *: * : Mflv_0405|M.gilvum_PYR-GCK ILDDFESYARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQPVE MAB_0939|M.abscessus_ATCC_1997 ILDEFEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVE MSMEG_0408|M.smegmatis_MC2_155 ILDDFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVE Rv1664|M.tuberculosis_H37Rv MVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPA-YWVEHVRKPVR Mb1692|M.bovis_AF2122/97 MVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPA-YWVEHVRKPVR MAV_3107|M.avium_104 MLDGFAAAAAGIEPRPPRIPLVSNLTGQLAGPGYGTPQ-YWVEHVRRPVR MMAR_2473|M.marinum_M MMAQFGATISGIVAHEPRIALVSTMTGQLAAAGYGTAS-YWVEHVRKPVR MUL_1655|M.ulcerans_Agy99 MMVQFGATISGIVAHEPRIALVSNMTGQLAAAGYGTAS-YWVEHVRKPVR MLBr_00135|M.leprae_Br4923 MLEEFVRVAAQVEVRKPQIGLVSNVTGELAGPDFGSPQ-YWGEHVSRAVR Mvan_1000|M.vanbaalenii_PYR-1 ALDEFESFAAQFEYRAPKLTLVCNRTGKVLTRQTRLDAPYWRRHAREPVR TH_4458|M.thermoresistible__bu --GRDAITATPPERWDTDSVGDGTRWGGFLERIDGFDAGFFGISPREAVR . . * :: ..*. Mflv_0405|M.gilvum_PYR-GCK FAKSVHTLADMNCKLLVEIGPRPVLTAAALSAWPDPATSPRVIASLRRTT MAB_0939|M.abscessus_ATCC_1997 FAKSVRTLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRNT MSMEG_0408|M.smegmatis_MC2_155 FAKSVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRPTT Rv1664|M.tuberculosis_H37Rv FFDGVGLAESLGARVFVEVGPGAGLEASV--------------ALLARDR Mb1692|M.bovis_AF2122/97 FFDGVGLAESLGARVFVEVGPGAGLEASV--------------ALLARDR MAV_3107|M.avium_104 FVDGVRLAESQGAGVFLEVGPGAALTAAVDQ--SLSTEGATAIATLPKDR MMAR_2473|M.marinum_M FADGVALAESLGAATFLETGPSAGLGTSV--------------ALLAKGR MUL_1655|M.ulcerans_Agy99 FADGVALAESLGAATFLETGPSAGLGTSV--------------ALLAKGR MLBr_00135|M.leprae_Br4923 FVDSARHLQTLGATHFIESGPSSGLMGAIEQ--SLAPAEAVVVSMMGKDR Mvan_1000|M.vanbaalenii_PYR-1 FADSAATLADLGCAVLMELGPQPVLIAAALRNWPETAPVPTAIASLRRDA TH_4458|M.thermoresistible__bu IDPQQRLLLEVAWEALEDAGLVPDRLAGS-----------------RTGV : : : * . Mflv_0405|M.gilvum_PYR-GCK ADQRQITEAVADAYVLGHLPRFA-AFRRDGARVLDLPTYPFEHRQYWFSD MAB_0939|M.abscessus_ATCC_1997 ADHRQITEAAADAYVLGHLPDFG-AFQHAPARKLDLPTYPFERRQYWFSD MSMEG_0408|M.smegmatis_MC2_155 ADHRQITEAVAAAYAAGHLPDFR-AFRQPDARKLDLPTYPFEHRQFWFSD Rv1664|M.tuberculosis_H37Rv PEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLG- Mb1692|M.bovis_AF2122/97 PEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLG- MAV_3107|M.avium_104 PETESALHAAGHLFTRGHRLDWAGVFAGLPARRVDLPTYAFARERFWLGG MMAR_2473|M.marinum_M PEVESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTYSFARQRFWLG- MUL_1655|M.ulcerans_Agy99 PEVESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTYSFARQRFWLG- MLBr_00135|M.leprae_Br4923 PELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETP Mvan_1000|M.vanbaalenii_PYR-1 DAHRCFTDALGVAYTTGHRLDFAGHLG--RRRTLDLPTYPFEHRAYWFPT TH_4458|M.thermoresistible__bu FTGVSTYDYLHLQLSHPELIDAYSGTGTASSIAANRLSYVFDFRGPSLTL :* * . Mflv_0405|M.gilvum_PYR-GCK SRE---PVAAAPQR---GARTETVRLLEDGRIEELAALLGGTVDDPFTFD MAB_0939|M.abscessus_ATCC_1997 KRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTLN MSMEG_0408|M.smegmatis_MC2_155 NRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLR Rv1664|M.tuberculosis_H37Rv ------DNGELSVDQTGKDAG----------------------------- Mb1692|M.bovis_AF2122/97 ------DNGELSVDQTGKDAG----------------------------- MAV_3107|M.avium_104 ASLAGAPAGAAPVGGGTRAPE----------------------------- MMAR_2473|M.marinum_M -------EGAGRKADSSDESG----------------------------- MUL_1655|M.ulcerans_Agy99 -------EGAGRKADSSDESG----------------------------- MLBr_00135|M.leprae_Br4923 G-----TDGTASVSGLGLGST----------------------------- Mvan_1000|M.vanbaalenii_PYR-1 TKVHTLPAGGGVESPAAESNTGDWLTGMSDEQRIDRIIELTRTELGNALR TH_4458|M.thermoresistible__bu DSACSSSLVAVHQACRSLRDGE---------------------------- Mflv_0405|M.gilvum_PYR-GCK VLNRLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVGD MAB_0939|M.abscessus_ATCC_1997 VLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVAD MSMEG_0408|M.smegmatis_MC2_155 VLNKLAARHNQQRSTHVDPDARYEIRWDAIASAAASTGAAA--DWILVGD Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 VAPAEIDPTAEFMTIGMDSMIAMELRGRLQAALGTPVPASLFFENPTVST TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLRI MAB_0939|M.abscessus_ATCC_1997 AAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALRI MSMEG_0408|M.smegmatis_MC2_155 DTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELYV Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 LAEALHALWLDASSDPSRRESPIPRVPHGCTLPCDVPLSHAQEQLWFLNQ TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMWLVTR MAB_0939|M.abscessus_ATCC_1997 VHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIWIVTR MSMEG_0408|M.smegmatis_MC2_155 VHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTR Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 LLPSSSAYNVA--------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDEWSRL MAB_0939|M.abscessus_ATCC_1997 GAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDEWAQF MSMEG_0408|M.smegmatis_MC2_155 DGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSGADT-EWPRL Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRADATYL MAB_0939|M.abscessus_ATCC_1997 IGRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSDATYL MSMEG_0408|M.smegmatis_MC2_155 IARITSPRDG---EDQIALRGDAVYAPRLVRRTGEPSDTPLPVREDRTYL Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEALRERHGCE MAB_0939|M.abscessus_ATCC_1997 VTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDALAA-QGCE MSMEG_0408|M.smegmatis_MC2_155 VTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQYACD Rv1664|M.tuberculosis_H37Rv -----------------------------------AIARLQSLAP----- Mb1692|M.bovis_AF2122/97 -----------------------------------AIARLQSLAP----- MAV_3107|M.avium_104 -----------------------------------LAHRLHALPR----- MMAR_2473|M.marinum_M -----------------------------------LRPRLDSVDS----- MUL_1655|M.ulcerans_Agy99 -----------------------------------LRPRLDSVDS----- MLBr_00135|M.leprae_Br4923 -----------------------------------EHALLGAVVERPDSG Mvan_1000|M.vanbaalenii_PYR-1 ----------------------IRVDIRGALDHEVLQRSLEAVVDRHEAL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VRVVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAE MAB_0939|M.abscessus_ATCC_1997 VRAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAE MSMEG_0408|M.smegmatis_MC2_155 VRVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAE Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 GVVLTGRL------------------------------------------ Mvan_1000|M.vanbaalenii_PYR-1 RTVFQSRHGAPQAILTPSQPIKLAFEEIGDEADIAAAAVREASVPFDIGA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWGGFGQAAYGAA MAB_0939|M.abscessus_ATCC_1997 VDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAA MSMEG_0408|M.smegmatis_MC2_155 VDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAA Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ----------------------SLANQPWLADHVIGGVVLFPGAGFVELV Mvan_1000|M.vanbaalenii_PYR-1 GPLLRARLFGVGDQRHVLVVTMHHIVTDGWSFRVLLGDLGRTYQALERGA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPA MAB_0939|M.abscessus_ATCC_1997 NAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPT MSMEG_0408|M.smegmatis_MC2_155 NAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPA Rv1664|M.tuberculosis_H37Rv ----PELQRQLVELVCFHAAIVLGRKSSHDIDPEC--------------- Mb1692|M.bovis_AF2122/97 ----PELQRQLVELVCFHAAIVLGRKSSHDIDPEC--------------- MAV_3107|M.avium_104 ----DEQQRVLRELVCEHAAAVLGHPGGDAIDPDR--------------- MMAR_2473|M.marinum_M ----KERFRQLVDLVCLHAAIVTGHSNSHQIDAER--------------- MUL_1655|M.ulcerans_Agy99 ----KERFRQLVDLVCLHAAIATGHSNSHQIDAER--------------- MLBr_00135|M.leprae_Br4923 IRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVV--------------- Mvan_1000|M.vanbaalenii_PYR-1 PAPLDDLPIQYADYARWQREQLTGPEFDAHIEFWK--------------- TH_4458|M.thermoresistible__bu ----CDLALAGGVNIMLSAGIGLNFTRAGVMATDG--------------- Mflv_0405|M.gilvum_PYR-GCK DALAGLSDAVISAAP---HPVVARVDWSRFLPLYQQAGRRGFLAELEREL MAB_0939|M.abscessus_ATCC_1997 DALAGLADVVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREV MSMEG_0408|M.smegmatis_MC2_155 EALAGMADVVAGPVQ----GVVAKIDWSRFLPLYQQAGRRAFLSELESEL Rv1664|M.tuberculosis_H37Rv -AFQDLG------------------------------------------- Mb1692|M.bovis_AF2122/97 -AFQDLG------------------------------------------- MAV_3107|M.avium_104 -AFADLG------------------------------------------- MMAR_2473|M.marinum_M -AFQDLG------------------------------------------- MUL_1655|M.ulcerans_Agy99 -AFQGLG------------------------------------------- MLBr_00135|M.leprae_Br4923 -AAADESSRRAVSVY----------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -ADLAGAPPLELDTD----------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVD MAB_0939|M.abscessus_ATCC_1997 PSHLA--GVAGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVD MSMEG_0408|M.smegmatis_MC2_155 PAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVD Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -----SRGDQSHGGWLLNAEGLLEVDAAEATVDLSLWPPEGAESVDISDA Mvan_1000|M.vanbaalenii_PYR-1 -----RPRPKSPTFRGARIRFDLGRERADALRDLCRAGNVTLSVPLLAAF TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAEIREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAA MAB_0939|M.abscessus_ATCC_1997 VSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVA MSMEG_0408|M.smegmatis_MC2_155 ADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAA Rv1664|M.tuberculosis_H37Rv --------------FDSMSGVELRNR-----------------------L Mb1692|M.bovis_AF2122/97 --------------FDSMSGVELRNR-----------------------L MAV_3107|M.avium_104 --------------FDSLIGVELRNR-----------------------L MMAR_2473|M.marinum_M --------------FESMTGVELRNR-----------------------L MUL_1655|M.ulcerans_Agy99 --------------FESMTGVELRNR-----------------------L MLBr_00135|M.leprae_Br4923 YPQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPTGVVVDGMGMHPALL Mvan_1000|M.vanbaalenii_PYR-1 ATVLQRYSGQHDLVIGTLTANRGRLETENLIGLFVNALPIRIRLDGDPDM TH_4458|M.thermoresistible__bu ----------RCKTFDARADGWVRGE---------------------GAG : * Mflv_0405|M.gilvum_PYR-GCK DYLLGDVLGLTEAAT-APKAATVVSTAADEPIAIVAVSCRFPGAPNPEAF MAB_0939|M.abscessus_ATCC_1997 DYLLGDVLGLAEQAKPAAQLASAVTGRTDEPIAIVAVSCRFPGAPDPEAF MSMEG_0408|M.smegmatis_MC2_155 DYLLVEVLGLGEQTN--VRQASTVTARTDDPIAVVAVSCRFPGAPDPESF Rv1664|M.tuberculosis_H37Rv QMAIGLPGLSLPRT------------------------------------ Mb1692|M.bovis_AF2122/97 QMAIGLPGLSLPRT------------------------------------ MAV_3107|M.avium_104 TTHT---GTALSRT------------------------------------ MMAR_2473|M.marinum_M RAVT---GLALSRT------------------------------------ MUL_1655|M.ulcerans_Agy99 RAVT---GLALSRT------------------------------------ MLBr_00135|M.leprae_Br4923 DAVLHALGLAIENTQ----------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 TELIDRIRGRMSEVL----------------------------------- TH_4458|M.thermoresistible__bu IVVLKPLREALADED----------------------------------- Mflv_0405|M.gilvum_PYR-GCK WDLLSGGVDAIREVPEDRFDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFD MAB_0939|M.abscessus_ATCC_1997 WDVLSGGVDAIREVPEDRFDIDEFYDPDPEVAGKTYTRFGGFLDGIDGFD MSMEG_0408|M.smegmatis_MC2_155 WELLAGGVDAIREVPEDRWDIDEFYDPDPDTPGKTYTRFGGFLDGIDGFD Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 --------------------------------------------ATTEMR Mvan_1000|M.vanbaalenii_PYR-1 --------------------------------------------AHQDVP TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGV MAB_0939|M.abscessus_ATCC_1997 PEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAGV MSMEG_0408|M.smegmatis_MC2_155 PEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFTGV Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 LPFCWRGVSLHAGGAGRVRARFTSAGADAIAVDIADSA------------ Mvan_1000|M.vanbaalenii_PYR-1 FDLIVTATAPDRDASRNPLFGVQLVVQPAAGAAELSSLGLDVAEIDTHTA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTA MAB_0939|M.abscessus_ATCC_1997 GANEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDTA MSMEG_0408|M.smegmatis_MC2_155 AANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDTA Rv1664|M.tuberculosis_H37Rv -----------------------------------LIFDYPTASALAECL Mb1692|M.bovis_AF2122/97 -----------------------------------LIFDYPTASALAECL MAV_3107|M.avium_104 -----------------------------------LIFDYPTPAALADHL MMAR_2473|M.marinum_M -----------------------------------IIFDYPTPMALARHL MUL_1655|M.ulcerans_Agy99 -----------------------------------IIFDYTTPMALARHL MLBr_00135|M.leprae_Br4923 ------------------------------GLPVLTVRSLVTRAMTAEQL Mvan_1000|M.vanbaalenii_PYR-1 KRDLTLTFFDDELLAGHVEYATELFDEARIERLIAHFREVVDALVSDRRL TH_4458|M.thermoresistible__bu -----------------------------------PIYAVIRGSAVNQDG Mflv_0405|M.gilvum_PYR-GCK CSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVG MAB_0939|M.abscessus_ATCC_1997 CSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVG MSMEG_0408|M.smegmatis_MC2_155 CSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPVG Rv1664|M.tuberculosis_H37Rv G-QLLGG--QHESSDD------------ESIWQLLKN------------- Mb1692|M.bovis_AF2122/97 G-QLLGG--QHESSDD------------ESIWQLLKN------------- MAV_3107|M.avium_104 RQQLLHD--EDPESDD------------ERIWSALRR------------- MMAR_2473|M.marinum_M DEQLSGG--NHEESDD------------DKIWSVLRT------------- MUL_1655|M.ulcerans_Agy99 DEQLSGG--NHEESDD------------DKIWSVLRT------------- MLBr_00135|M.leprae_Br4923 RTAVTAAGGALEQGPM------------DLVWSPIPLSSDGHGGGLPSV- Mvan_1000|M.vanbaalenii_PYR-1 RLSEVTMLTESERAHY------------AVTRSPLAPTARSVPELFEMT- TH_4458|M.thermoresistible__bu RTNGLMAPSRTAQEVVLT-------------------------------- Mflv_0405|M.gilvum_PYR-GCK RCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGA MAB_0939|M.abscessus_ATCC_1997 RCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGA MSMEG_0408|M.smegmatis_MC2_155 RCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDGA Rv1664|M.tuberculosis_H37Rv --------------------IPIHQLRRT-------------------GL Mb1692|M.bovis_AF2122/97 --------------------IPIHQLRRT-------------------GL MAV_3107|M.avium_104 --------------------IPLRELRRT-------------------GL MMAR_2473|M.marinum_M --------------------IPVRELRRS-------------------GM MUL_1655|M.ulcerans_Agy99 --------------------IPVRELRRS-------------------GM MLBr_00135|M.leprae_Br4923 ----VS-WADYCAGRGNDTGVVVWEFGSASAGAQAPVDSVAAVYSATHAA Mvan_1000|M.vanbaalenii_PYR-1 ----ADRTPDAVAVRAPDRSLTYRELDAAANRLARRLRALG------VGA TH_4458|M.thermoresistible__bu ------------------------------------------------DA Mflv_0405|M.gilvum_PYR-GCK SSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQA MAB_0939|M.abscessus_ATCC_1997 SSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQA MSMEG_0408|M.smegmatis_MC2_155 SSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQA Rv1664|M.tuberculosis_H37Rv LDKLLLLAGQPEE---------------------SLAGRTVSDEVIDSLS Mb1692|M.bovis_AF2122/97 LDKLLLLAGQPEE---------------------SLAGRTVSDEVIDSLS MAV_3107|M.avium_104 LDKLLLLAGMPET---------------------ATTDAKISDADIDSLS MMAR_2473|M.marinum_M LDKLLLLAGQDES---------------------PAPDAAVSDDVIDSLS MUL_1655|M.ulcerans_Agy99 LDKLLLLAGQDER---------------------PAPDAAVSDDVIDSLS MLBr_00135|M.leprae_Br4923 LQVLQFWFGQDRAGTLVVL---------------TRGAVGLVGEGISDLA Mvan_1000|M.vanbaalenii_PYR-1 GAAVGLRVGRSAAMAVGMLGILK------AGGVYVPVDPTYPQDRIEHML TH_4458|M.thermoresistible__bu YRRAGVSPGVVQY-------------------VEAQGIGTPVGDAIEVGA . * *. Mflv_0405|M.gilvum_PYR-GCK AAAAYAGARDADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQ MAB_0939|M.abscessus_ATCC_1997 AAAAYGGSRDADRPLLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVLPQ MSMEG_0408|M.smegmatis_MC2_155 AAAAYGAGRDADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHGVLPQ Rv1664|M.tuberculosis_H37Rv PEALIGLALDED---------------ENDIR------------------ Mb1692|M.bovis_AF2122/97 PEALIGLALDED---------------ENDIR------------------ MAV_3107|M.avium_104 PDALIAMALNSA---------------DDDEAE----------------- MMAR_2473|M.marinum_M PEALVAMALDSE---------------DDDPD------------------ MUL_1655|M.ulcerans_Agy99 PEALVAMALDSE---------------DDDPD------------------ MLBr_00135|M.leprae_Br4923 AAAVWGMVRSAQ---------------SEHSGKIVLIDTDS--------- Mvan_1000|M.vanbaalenii_PYR-1 GEAGVALLLDER---------------DVDGAEAGLCSAER--------- TH_4458|M.thermoresistible__bu LGTVLAEDRPPDSPCLIG-------------------------------- : . Mflv_0405|M.gilvum_PYR-GCK SLHFDTPSPHIPWDSLPVRVVDTAMPWQPNGRPRRAGVSSFGFTGTNAHV MAB_0939|M.abscessus_ATCC_1997 SLHFDNPSPHIPWESLPVRVVDKAIPWQANGRPRRAGVSSFGFTGTNAHV MSMEG_0408|M.smegmatis_MC2_155 SLHFENPSPHIPWDALPVRVIDEPVPWQTNGRVRRAGVSSFGFTGTNAHV Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSPEALVA MAB_0939|M.abscessus_ATCC_1997 LIEEAPQPQATP----------DEDDASTPQSAPVSVLPLSARSPEALAA MSMEG_0408|M.smegmatis_MC2_155 LVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLALSARSPEALVE Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LAQRYETWLTAHPEADLADVCRTAGTGRSHFEHRAALVVDSVESARIALT MAB_0939|M.abscessus_ATCC_1997 VAQRYESWLAAHPDVDLEDVCLTAGRGRSHFEHRAALVVDSIQTAREGLL MSMEG_0408|M.smegmatis_MC2_155 LARRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAALVVDSVERAREGLA Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ----------------AVDVAVLADLGESQLLVRCNTVHAARLSPAPQLL Mvan_1000|M.vanbaalenii_PYR-1 ----------------LENLAAADDLAYIMYTSGSTGRPKGVAVTHGSVV TH_4458|M.thermoresistible__bu --------------------SVKTNIGHLEAAAGIAGLIKVALALRHRMI Mflv_0405|M.gilvum_PYR-GCK DLAQNRLRPGVVRGEHLNHPTTAWMFTGQGSQYPGMARELFDTEPVFADT MAB_0939|M.abscessus_ATCC_1997 ELAQNRLRPGVVRGEHTNHPTTAWLFTGQGSQYPGMARELFDAEPVFAET MSMEG_0408|M.smegmatis_MC2_155 ALAEGRTPAGVVRGEHVHRPTTAWLFTGQGSQYPGMARELFDTQPVFAQT Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ALPVGESMWRLAADGGGTLEDLVIQPCPE--------------------- Mvan_1000|M.vanbaalenii_PYR-1 EYAETLGRELGITGEDVYLETASISFSSS--------------------- TH_4458|M.thermoresistible__bu PPTLNFTEPNPTIEFDKLPVRVAQTLTPWPDDS----------------- Mflv_0405|M.gilvum_PYR-GCK VTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTSFAQPALFAVEM MAB_0939|M.abscessus_ATCC_1997 VTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTSFAQPALFAVEM MSMEG_0408|M.smegmatis_MC2_155 VRQCAEAVADMLPRPLLDVLFATDRET----ADLLQHTSFAQPALFAVEM Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ----------------------------------------VQAPLQAGHM Mvan_1000|M.vanbaalenii_PYR-1 ----------------------------------------IRQMLVPFAV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGRLFG MAB_0939|M.abscessus_ATCC_1997 GLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGARLIAERGRLFG MSMEG_0408|M.smegmatis_MC2_155 GLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGARLMAERGRMFG Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 RVA-----------------------VAAVGVN-FRDVVAALG------- Mvan_1000|M.vanbaalenii_PYR-1 GAE-----------------------VVIATTEERRDPAALLR------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SLPEGGRMVAVFADAKRVEQVAADFPRVSVGAYNGPNTVLSGPGEDLEQI MAB_0939|M.abscessus_ATCC_1997 GLPAGGRMVAVFSDAKHVEQIAGEFPRVSVGAYNGPNTVLSGPGEDLEQA MSMEG_0408|M.smegmatis_MC2_155 SLPEGGRMVAVFADAEHVEQVAGEFPRVSVGAYNGPNTVLSGPGEDLEEI Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYAAQLQFAAPTLPLVC MAB_0939|M.abscessus_ATCC_1997 VARFQEEGIRCTWLETSHAFHSELLDPILDEFESYAAQVQFAAPTLPLVC MSMEG_0408|M.smegmatis_MC2_155 VERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYAAQFQFAAPTLPLVC Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NRTGAVLTGQTSLDAQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQP MAB_0939|M.abscessus_ATCC_1997 NRTGAVLTAQTPIDGQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQP MSMEG_0408|M.smegmatis_MC2_155 NRTGAVLTGQTPLDAQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQP Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 --------------------------MYPGQAPPLGAEGAGVVIEIGPEV Mvan_1000|M.vanbaalenii_PYR-1 --------------------------RIGESAVTVADLVPTVVRRVIDVV TH_4458|M.thermoresistible__bu -----------------------GRAVAGVSAFGFGGTNAHVVLAEAPQV Mflv_0405|M.gilvum_PYR-GCK VLTGAAVQVWPEHLAAPRAIASLRKGVADRRQIADALAAAYIGGHKPDFA MAB_0939|M.abscessus_ATCC_1997 VLTGAAVQVWPEHLAPPRAIVSLRKGVEDRRQIADALASAYVSGHRPNFA MSMEG_0408|M.smegmatis_MC2_155 VLTGAAVQVWPEHMAAPRAVASLRKGVADRRQIADALASAYVGGHRPDFA Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 TGV-----------AVGDAVMGFLGGAGPLAVVHQQLITQMPQGWSLAEA Mvan_1000|M.vanbaalenii_PYR-1 AAA-----------DAGQRTASRRNRLRLLLTASEPLRAGVVRAWREQLG TH_4458|M.thermoresistible__bu RAAATADDHADGFVEILPLSARSQAALDALAERYESALTGGVPPADLCHT Mflv_0405|M.gilvum_PYR-GCK ALHEQRGVRLELPTYPFQRRRFWPKSAGMAIDGRVGASAGSGILGSGKDL MAB_0939|M.abscessus_ATCC_1997 ALQRHPRRTVELPTYPFQRRRFWPKSSGTAIEG--GGGLPSGILGRGEDL MSMEG_0408|M.smegmatis_MC2_155 AVHRQPRRPVELPTYPFQRRRFWPKASSIAVDG---GTAASGILGSGKDL Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 AAVP---------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 GGAS---------------------------------------------- TH_4458|M.thermoresistible__bu AGAR---------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ASGDSVYTSRLSVKTQPWLSDHVIYGTVVVPGATYAAMALAAVGTPAHAK MAB_0939|M.abscessus_ATCC_1997 ASGDSVYISRLSVRSQPWLSDHVIYGTVVVPGATYAAMALAAVGTPARAK MSMEG_0408|M.smegmatis_MC2_155 ASGDTIYTSRLSVKSQPWLADHVIYGTVVVPGATYAAMALAAVGTPARLK Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -----------VVFLT---ALFGLADLAGIRAGESVLIHAGTGGVGMAAV Mvan_1000|M.vanbaalenii_PYR-1 -----------WINMYGQTETTGIVSLHPVGEPDGDAQSIVPIGRPRANV TH_4458|M.thermoresistible__bu -----------RAHHDHRLAVVGASRAELIGALAAYRRGEPHPGVFTGRS Mflv_0405|M.gilvum_PYR-GCK DVFFYEPIILPEKSSREVQLTVHPSVDGE-SKFQVHSRPYGERGAEWALN MAB_0939|M.abscessus_ATCC_1997 DVFFYEPIILPEKSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSLN MSMEG_0408|M.smegmatis_MC2_155 DVFFYEPIILPEKASREVQLTLHPADGGSVLSFQIHSRPYGERGADWSLN Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 QFARHWGVEIFVTASRGKWDTLRDM------------------------- Mvan_1000|M.vanbaalenii_PYR-1 GMYVLDRLMRPVPPGVGGALFIAGP------------------------- TH_4458|M.thermoresistible__bu QSGHRSGVVFVFSDEGSQWR------------------------------ Mflv_0405|M.gilvum_PYR-GCK AEGVVASGVGD---SPAAAGDLEDPVDEAIERLNRMRPQELFETFADLEL MAB_0939|M.abscessus_ATCC_1997 AEGTVVTGIGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLEL MSMEG_0408|M.smegmatis_MC2_155 AEGTVDTAGSD---PDAAADEQSDPVDEVIERLERMRPQDLFETFADLEL Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AWGPTWSGSLKSLWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGV MAB_0939|M.abscessus_ATCC_1997 AWGPTWSGSLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGV MSMEG_0408|M.smegmatis_MC2_155 AWGPTWSGSLKSLWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGV Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AFPAFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDS MAB_0939|M.abscessus_ATCC_1997 AFPAFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDS MSMEG_0408|M.smegmatis_MC2_155 AFPAFPALLAAEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDS Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ETQVFDLEYLDRDGRHLGGVREFTVKRAPREALLRGLGGDATRLLYTLGW MAB_0939|M.abscessus_ATCC_1997 ETQVFDLDYLDRDGRHLGGIREFTVKRAPREALLRGLGGDATRLLYTLGW MSMEG_0408|M.smegmatis_MC2_155 ETQVFELEFVDLGGRALGGIREFTVKRAPREALLRGLGGDATRLLYTLGW Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------GFDDDHIGDSRTLEFEE-- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------ALAREYVGDPTLTAQKY-- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK HEVPVP----ESGDGAAPQGTWLIGGFDELAVSVPGCIPADR-TNPESLR MAB_0939|M.abscessus_ATCC_1997 HEVAVPPVAGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRETDPELLG MSMEG_0408|M.smegmatis_MC2_155 HEVPPP------PSADDAVGTWLIAGFDELAAKVPGCVPIDRNTDLQVLG Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QLLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVH MAB_0939|M.abscessus_ATCC_1997 EVLVAAKERGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVH MSMEG_0408|M.smegmatis_MC2_155 EVLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLSAVH Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TVQ---GGEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEE MAB_0939|M.abscessus_ATCC_1997 TVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEE MSMEG_0408|M.smegmatis_MC2_155 AAQ---GPSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEE Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ---------------------KFLAVTDGRGVDVVLDSLAG--------- Mvan_1000|M.vanbaalenii_PYR-1 ---------------------VPAPWNPAERLYVSGDMVRLGWDGTIEYR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWS MAB_0939|M.abscessus_ATCC_1997 PALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWS MSMEG_0408|M.smegmatis_MC2_155 PALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWA Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------DFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFD Mvan_1000|M.vanbaalenii_PYR-1 GRADRQVKIRGLRVEPAEIDRVLLEHPGVREAVTVVREANADGAALVAYF TH_4458|M.thermoresistible__bu -----------GMAQRLYAEDQVFRTALAECDRALRRHMEISPLSELLAD Mflv_0405|M.gilvum_PYR-GCK RSGHLTVPRGGDYVLAPTERGAIDNLRLTDSEVPPPAEGYVQVRVEAAGL MAB_0939|M.abscessus_ATCC_1997 RTGHLTVPRGSDYVLAPTERGAIDNLRITEKEVPAPDEGYVQVRVEAAGL MSMEG_0408|M.smegmatis_MC2_155 RSGHLTLPRGGDFVLAPTERGAIDNLRLTETDVPEPDEGYVQVRVEAAGL Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 LSEAGPVRMQ---------------------------EMLCEVR------ Mvan_1000|M.vanbaalenii_PYR-1 TTGDTPVPVG---------------------------ELRAHARRQLPDH TH_4458|M.thermoresistible__bu PSHSR--------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGA MAB_0939|M.abscessus_ATCC_1997 NFRDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGA MSMEG_0408|M.smegmatis_MC2_155 NFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGA Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ----ELFDTQVLHRLPVTSWDVRCAPAAFR-------------------- Mvan_1000|M.vanbaalenii_PYR-1 MVPSAFTALEQLPLTPNGKLDRTALPEVTI-------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FASRFNVPGQFLAPIPDGVSAVEAATIPAAALTVRLSFDWAQVKSGDKVL MAB_0939|M.abscessus_ATCC_1997 FGSRFNVPAQFLAPIPDGISGVEAATIPAAALTVRLSFDWAQLKPGDKVL MSMEG_0408|M.smegmatis_MC2_155 FASRFNVPAQFLAPIPDGIGAVEAATIPAAALTVRLAFDWAQLKPGDKVL Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ---------------------FMSQARHIGKVVLTMPSALADGLAEGTVL Mvan_1000|M.vanbaalenii_PYR-1 ---------------------TRDQEIEYVPPRSGVEQSLAEIWSDTLQL TH_4458|M.thermoresistible__bu ----------------------MDEVTIASPALFAVQVALAALWQSWG-- Mflv_0405|M.gilvum_PYR-GCK IHAASGGVGLAAVQMAQQCGAEVYATASTFKRATLRKLGVKHVYDSRTTD MAB_0939|M.abscessus_ATCC_1997 IHAASGGVGLAAIQMAQQFGAEVFATASTFKRATLRKLGVKYVYDSRTTD MSMEG_0408|M.smegmatis_MC2_155 IHAASGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLGVKYVYDSRTTD Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ITGASG------------------AIGGVLARHMVSAYGVRHLVLA---- Mvan_1000|M.vanbaalenii_PYR-1 EQIGAG------------------DNFFELGGHSLLAAQVRSRIHQ---- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWT MAB_0939|M.abscessus_ATCC_1997 FADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWT MSMEG_0408|M.smegmatis_MC2_155 FADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWS Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ----------------SRRGDRAEGAVELAAELVGAGAKIQ-VVACDVAD Mvan_1000|M.vanbaalenii_PYR-1 ----------------LLGVELPLEALFEDQTLSDLAHRIEGDTGVDTSE TH_4458|M.thermoresistible__bu ---------------------VEPAAVIGHRMGEVAAAHVAGVLGLDDAA Mflv_0405|M.gilvum_PYR-GCK VEQMAAARPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWTPLPA MAB_0939|M.abscessus_ATCC_1997 TEQMAQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWTPLPA MSMEG_0408|M.smegmatis_MC2_155 HEQMAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWTPLPA Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 NDAVRGLFAQLSREFPPVRGVIHA---------AGVLDDGAITSLTPDRV Mvan_1000|M.vanbaalenii_PYR-1 APLLRPVARTGPPPLSYAQELMWR---------NECDDPGSPAHWIDVSI TH_4458|M.thermoresistible__bu ALLCGRTRLSRLASTGAVR----------------EGLDGLLANLRPDDP Mflv_0405|M.gilvum_PYR-GCK EVYPLTEARAAFRRMQQARHIGKIVVQIPNPLQPQPDRSYLITGGLGAIG MAB_0939|M.abscessus_ATCC_1997 EIYPLTEARTAFRRMQQARHIGKIVCQMPNPLAPRPDRTYLITGGLGAIG MSMEG_0408|M.smegmatis_MC2_155 EIYPITEARSAFRRMQQARHIGKIVLQVPKPLQPQQDRSYLITGGLGAIG Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 DTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAANAF Mvan_1000|M.vanbaalenii_PYR-1 RITGPLDPDLVVRGIQAATHRHELLRTVFRPSGASAAQVILDSYTPEVPI TH_4458|M.thermoresistible__bu RIPLYSTVTGDAVTGRGFGAAHWMENLHSPVRFSAAVRRLLGRGHDAFLE Mflv_0405|M.gilvum_PYR-GCK LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADIADRTKARLHVFTADVG MAB_0939|M.abscessus_ATCC_1997 LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEITERSKTRIHVFTADVG MSMEG_0408|M.smegmatis_MC2_155 LHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCRIHTYAADVG Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 LDGLAAYRQAAGLAGTSLAWG-----------------------LWEQPG Mvan_1000|M.vanbaalenii_PYR-1 FDGAAALQHDVWPDQPDLATCPPLRAELCRIDDGNHILRLRVHRILADGY TH_4458|M.thermoresistible__bu ISAHPMLLSAVQEDAADLGRSCTTLVSMRRGECGRDVLMTSLAALYASGH Mflv_0405|M.gilvum_PYR-GCK VEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVERFRTALAPKA MAB_0939|M.abscessus_ATCC_1997 AESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVERFRTTLAPKA MSMEG_0408|M.smegmatis_MC2_155 DEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRTTLAPKA Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 GMNAHLSSRDLARISRSGLAPMNPAQALELFDAALVIDHPFMVTALLDR- Mvan_1000|M.vanbaalenii_PYR-1 TMRLLLSEIGGLVASSAGLPDFPLLDGDLHYADYAIWERSWLTGAALQRR TH_4458|M.thermoresistible__bu AVDWARVHPHGSHCTAAPTYPWQRQRFWLDIDRCDTGDGAGTGGTAERTV Mflv_0405|M.gilvum_PYR-GCK FGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLDGLVAQR MAB_0939|M.abscessus_ATCC_1997 FGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLDGLIAQR MSMEG_0408|M.smegmatis_MC2_155 YGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLDGLVAKR Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -AALDAQAQAG-------ALPPLFSRLVRRSRRRQIEDPGDATQSKLALV Mvan_1000|M.vanbaalenii_PYR-1 IDHFRREFAVG-------ELPPALPTDHPRTGRSRRAAGQLDFEFPAEVA TH_4458|M.thermoresistible__bu VPAPLPAPSAS-------AAPTVDEVLLCADQRERRELLESYLRDRVAAE Mflv_0405|M.gilvum_PYR-GCK RAQGLPATGVNFGPWARGGMASSEAAAANISAQGLIPLEPSAALTAMAEV MAB_0939|M.abscessus_ATCC_1997 RAQGLPATGINFGPWGQGGMASSEAATANISAQGLIPLDPSAALAALAEV MSMEG_0408|M.smegmatis_MC2_155 RAQGLVATGINFGPWGQGGMASSEAATANITAQGLIPLDPSAALHALAEV Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 QRLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDP--------NTKFQ Mvan_1000|M.vanbaalenii_PYR-1 AAARALAVREHASLYTVLLAGFAAALGGYAGRRTVVLGSPVTRRNDPVTQ TH_4458|M.thermoresistible__bu LGVLPPLLDVAAPLSTLGIDSLTAAELRARVERDLGIVIPVAQLLNGPSV Mflv_0405|M.gilvum_PYR-GCK VANGTAQATVLKANWQRAAKVLGSSRPPILDLVLPSAVGEITGDSELLKQ MAB_0939|M.abscessus_ATCC_1997 VANGTGQATILKANWQRAAKVLGSSRPPILDLVLPSAVGEVTGDSELLKQ MSMEG_0408|M.smegmatis_MC2_155 IANGSGQATVLKANWQRAAKVLGSARPPILDLVLPSAAGEATGDSELLKQ Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 DLGFDSLTAVELRNRLKSATGLTLPPTVIFDHPTPTAVAEYVAQQMLKSR Mvan_1000|M.vanbaalenii_PYR-1 LMLGPFMNTVPLRIDLPEGGGLAAMVQNMKTTVLGALSHQDAPSQHVIAA TH_4458|M.thermoresistible__bu SDLAEWISTTMVGFGSTTPEPESAGVPGRSRPPDGAVASGSGDGGRWIEL Mflv_0405|M.gilvum_PYR-GCK LQEIPVPQRAGFVTEFLQKEVQNFLRLAQPPAATSRFLDLGTDSLMAIEL MAB_0939|M.abscessus_ATCC_1997 LMEIPVPQRAGFVTEFLQREVQNFLRLAQPPAATSRFLDLGTDSLMAIEL MSMEG_0408|M.smegmatis_MC2_155 LMEIPIPQRAGFVTEFLQREVQNFLRLASPPAASSRFLDLGTDSLMAIEL Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 PAESGDETSQAVEPKVEEVSVHA--------------------------- Mvan_1000|M.vanbaalenii_PYR-1 LAAEHGPSAAAIGETVFLMDDPVPGEFAAGGFRLTRVPPERVIARRELTA TH_4458|M.thermoresistible__bu LNQMPEVSDDTVDELLRQLLAAGENHDDTQLH------------------ Mflv_0405|M.gilvum_PYR-GCK RNRLHSQFGGAFTINATAVFDYPTIGGLAEYLVAQLPDAETPQAAP---- MAB_0939|M.abscessus_ATCC_1997 RNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAV MSMEG_0408|M.smegmatis_MC2_155 RNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA----- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- Mvan_1000|M.vanbaalenii_PYR-1 AMSTRNRQITGTLTYDSTLFDHPSIECIVAGFIGAVSALHVDCA------ TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---QSESEPGPDVTE-------- MAB_0939|M.abscessus_ATCC_1997 ESAEAESGAGPAAASDAVSELKE MSMEG_0408|M.smegmatis_MC2_155 ----------------------- Rv1664|M.tuberculosis_H37Rv ----------------------- Mb1692|M.bovis_AF2122/97 ----------------------- MAV_3107|M.avium_104 ----------------------- MMAR_2473|M.marinum_M ----------------------- MUL_1655|M.ulcerans_Agy99 ----------------------- MLBr_00135|M.leprae_Br4923 ----------------------- Mvan_1000|M.vanbaalenii_PYR-1 ----------------------- TH_4458|M.thermoresistible__bu -----------------------