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VMSRATSLRRQHGDGDQEFASAVAIIGVACRIPGAANPGEFWELVSEGHEVAKPIDHVGDFDAEFFNVSP REATAMDPRQRLALELAWELFEDARIVAESVRGEPIAVYLGAMNDDYALLTLDQAPDKLDHYSFAGASRG MIANRVSSGFALHGPSMTVDCGQSSSLVAVHLAPGYLRGAGDATMAIAGGIHLNLASETGRLETEFGAVS ASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDGNSIRAVILGEAVGSAGHTAGGLAAPSAAAEADVM RRAMASAGVDPNQIDYIEAHGTGTRIGDTTEAQALSEVFATRETPVWLGSVKSNIGHTGAAAGAAGLIKT VLSLENGAIPASLNFVGDSAGTDMESHGLHVSTTLTPWPRGAGPRRAGVSSFGMGGTNAHVIVQQAPIPQ EAVADPDGTEATVPWLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTRSVFEHRAVLVGGDRG GFMAGLAALASGEPGVNLVAGRAGSGGKTVLVFPGQGAQWLGMGRDLYGRFPAFAKAFDTVADALDEHLR LPLREVIWGADASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEISAAHVAGVLSLTDAAR LVSARGRLMAQLPPGGVMVAVAASAAQVAPMLQEGVSIAAVNGPDSVVISGPEAATAVVADRLTGQGCRA HRLAVSHAFHSALMEPMMVQFGATISGIVAHEPRIALVSNMTGQLAAAGYGTASYWVEHVRKPVRFADGV ALAESLGAATFLETGPSAGLGTSVALLAKGRPEVESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTY SFARQRFWLGEGAGRKADSSDESGLRPRLDSVDSKERFRQLVDLVCLHAAIATGHSNSHQIDAERAFQGL GFESMTGVELRNRLRAVTGLALSRTIIFDYTTPMALARHLDEQLSGGNHEESDDDKIWSVLRTIPVRELR RSGMLDKLLLLAGQDERPAPDAAVSDDVIDSLSPEALVAMALDSEDDDPD
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_1655 | pks9 | - | 100% (1030) | polyketide synthase Pks9 |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 46.72% (899) | polyketide synthase Pks15/1 |
M. ulcerans Agy99 | MUL_2266 | pks12 | 0.0 | 45.22% (889) | polyketide synthase, Pks12 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1692 | pks9 | 0.0 | 62.97% (1018) | polyketide synthase pks9 |
M. gilvum PYR-GCK | Mflv_0405 | - | 1e-156 | 38.80% (897) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv1664 | pks9 | 0.0 | 63.06% (1018) | polyketide synthase pks9 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 45.19% (894) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 1e-156 | 39.13% (892) | polyketide synthase |
M. marinum M | MMAR_2473 | pks9 | 0.0 | 98.54% (1029) | polyketide synthase Pks9 |
M. avium 104 | MAV_3107 | - | 0.0 | 61.64% (1027) | polyketide synthase |
M. smegmatis MC2 155 | MSMEG_0408 | - | 1e-153 | 38.29% (888) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4458 | - | 1e-140 | 34.35% (1080) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
M. vanbaalenii PYR-1 | Mvan_0269 | - | 1e-157 | 39.09% (898) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 MDSAENPIESTPRFAIIGYAARFPGAADAEEFWDVLREGRDAISEVPADR Mvan_0269|M.vanbaalenii_PYR-1 MGSAEHPNGPAPRFAIVGYAARFPGAPDADAFWDVLREGRDAISDVPRDR Mflv_0405|M.gilvum_PYR-GCK MGSAAHQGESAHRFAIVGYAGRFPGARDAESFWELLADGRDAISEVPEDR MSMEG_0408|M.smegmatis_MC2_155 MVSAEHPIEPTPSFAIIGYAARFPGAASAEEYWALLRDGREAISDVPKDR TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPFFGMSTREVRLMDPQH Mvan_0269|M.vanbaalenii_PYR-1 WDAEEFFDPEPGAPGKVVTRRAGFVDDVTGFDAPFFGMSTREVRMMDPQH Mflv_0405|M.gilvum_PYR-GCK WDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPFFGMSTREVRLMDPQH MSMEG_0408|M.smegmatis_MC2_155 WDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPFFGMSAREVRLMDPQH TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATHDYLGMASDELTFPEI Mvan_0269|M.vanbaalenii_PYR-1 RLLLETAWRAVEHSGTAPTALAGSNTGVFVGLATHDYLGMASDELTYPEI Mflv_0405|M.gilvum_PYR-GCK RLLLETAWRAIEHSGTAPSELANTNTGVFVGLATHDYLGMASDELSYPEI MSMEG_0408|M.smegmatis_MC2_155 RILMETAWRAVEHSGIAPTSLANSNTGVFVGLATHDYLGMASDELTYPEI TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACSSSLVAIHQACQALQL Mvan_0269|M.vanbaalenii_PYR-1 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL Mflv_0405|M.gilvum_PYR-GCK EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL MSMEG_0408|M.smegmatis_MC2_155 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GECDLALAGGANVLLTPATMITFSHAHMLAPDGKCKTFDAAADGYVRGEG Mvan_0269|M.vanbaalenii_PYR-1 GECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG Mflv_0405|M.gilvum_PYR-GCK GECDLALAGGANVILTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG MSMEG_0408|M.smegmatis_MC2_155 NECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA Mvan_0269|M.vanbaalenii_PYR-1 CGVIVIKRLEDAVRDGDRIRAVIRGSSINQDGASGGLTVPNGVAQQRVIA Mflv_0405|M.gilvum_PYR-GCK CGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIG MSMEG_0408|M.smegmatis_MC2_155 CGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAGAAYGIGRETNDPLLI Mvan_0269|M.vanbaalenii_PYR-1 DALKRSDLEPKDVGYLEAHGTGTSLGDPIEAQAAGAVLGAGREPSRPLLI Mflv_0405|M.gilvum_PYR-GCK DALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAGAALGPGREPQRPLLI MSMEG_0408|M.smegmatis_MC2_155 DALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLI TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLP Mvan_0269|M.vanbaalenii_PYR-1 GSAKTNIGHLEAAAGIAGVIKVILSLEHRTLPKHLNFENPSPHIPWDRLA Mflv_0405|M.gilvum_PYR-GCK GSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLP MSMEG_0408|M.smegmatis_MC2_155 GSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLP TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEVVREARPWGRN---GRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVE Mvan_0269|M.vanbaalenii_PYR-1 VEVVKETIPWERD---GGPRIAGVSSFGFAGTNAHVILEEAP--EQAAAP Mflv_0405|M.gilvum_PYR-GCK VEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAHVILEEAP---LAAEP MSMEG_0408|M.smegmatis_MC2_155 IEVVRETVPWQRN---GKPRIAGVSSFGFAGTNAHVILEEAPAVGTPATT TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PPAPAGGRKFSILPLSARTPAALAQLADKYRAWLNAHPEAALADLCFTAG Mvan_0269|M.vanbaalenii_PYR-1 GPVQQPDRRFSLLPLSARTPAALTQLAGQYRDWWTAHPEATLADVCFTAG Mflv_0405|M.gilvum_PYR-GCK AQESVDDGRFTLLPLSARTPAALMAVADRYRDWLVANPDATLADLCFTAG MSMEG_0408|M.smegmatis_MC2_155 EPVE-DPRRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAG TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VGRAHLEHRAALVVNTREAAVELLSAVADDRPAPGLGRGESHDTPKTAWL Mvan_0269|M.vanbaalenii_PYR-1 AGRAHLEHRAALVVNSAESAVELLGALADDRPAPGLVRGESHDTPKTAWL Mflv_0405|M.gilvum_PYR-GCK TARSHLEHRAALVVNTREAALDLLGALADDRPAPGLVRGESHDTPKTAWL MSMEG_0408|M.smegmatis_MC2_155 TARAHLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWL TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FTGQGSQYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD- Mvan_0269|M.vanbaalenii_PYR-1 FTGQGSQYPGMARELYDTEPVFAETLNRCAEAVADVLEKPLLDVIFDAE- Mflv_0405|M.gilvum_PYR-GCK FTGQGSQYPGMSRELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDG MSMEG_0408|M.smegmatis_MC2_155 FTGQGSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDAD- TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 --GPEAEETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYS Mvan_0269|M.vanbaalenii_PYR-1 --ADDAEKTLQNTCYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYS Mflv_0405|M.gilvum_PYR-GCK VLDTDSNETLRHTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYA MSMEG_0408|M.smegmatis_MC2_155 ELDGDTESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYS TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AACVAEVFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEF Mvan_0269|M.vanbaalenii_PYR-1 AACVAGVFSLTDGARLMAERGRLFGSLPEGGRMVAVFTTAERAEAMTDEF Mflv_0405|M.gilvum_PYR-GCK AACVAGVLSLRDGARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEY MSMEG_0408|M.smegmatis_MC2_155 AACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEY TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PSLSVAAYNGANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALL Mvan_0269|M.vanbaalenii_PYR-1 PSLSVAAYNGTNTVLSGPAGDLEKAVATLSADGVRCDWLDTSHAFHSALL Mflv_0405|M.gilvum_PYR-GCK PALSVAAYNGANTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALL MSMEG_0408|M.smegmatis_MC2_155 PSLSVAAYNGANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALL TH_4458|M.thermoresistible__bu ------------------LLSLLRQRSERYGDKIAFDYCTGEQEHSRLTY MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DPILDEFEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQP Mvan_0269|M.vanbaalenii_PYR-1 DPILDDFESYANQFDFAAPQRILIDNRTGTALGRSVQLDGTYWRRHARQP Mflv_0405|M.gilvum_PYR-GCK DPILDDFESYARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQP MSMEG_0408|M.smegmatis_MC2_155 DPILDDFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQP TH_4458|M.thermoresistible__bu QELDIRARAIAAHLQDQGVAGERVLVLCPSGLDFITAMFGCFYVGAVAVP MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEFAKSVRTLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRR Mvan_0269|M.vanbaalenii_PYR-1 VEFAKSVRTLAEMNCKLLVEIGPRPVLTAAALGAWPDPATAPRVIASLRR Mflv_0405|M.gilvum_PYR-GCK VEFAKSVHTLADMNCKLLVEIGPRPVLTAAALSAWPDPATSPRVIASLRR MSMEG_0408|M.smegmatis_MC2_155 VEFAKSVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRP TH_4458|M.thermoresistible__bu VHPPVHNRLLSRVASIVADVRATSVLTTAATRADLKEILDGLHDGDPLRW MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NTADHRQITEAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFS Mvan_0269|M.vanbaalenii_PYR-1 TAADHRQITEAVADAYVLGHLPEFGAFRDAGARKLDLPTYPFEHRQYWFR Mflv_0405|M.gilvum_PYR-GCK TTADQRQITEAVADAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFS MSMEG_0408|M.smegmatis_MC2_155 TTADHRQITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFS TH_4458|M.thermoresistible__bu LAVDTIEADDETSWTPTTVDTDSVAFVQYTSG------------------ MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DKRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTL Mvan_0269|M.vanbaalenii_PYR-1 DNQDPD----GSEALQPRTPSTEAVRLLEDGRIEELATLLDGAAGDQQTL Mflv_0405|M.gilvum_PYR-GCK DSREPV------AAAPQRGARTETVRLLEDGRIEELAALLGGTVDDPFTF MSMEG_0408|M.smegmatis_MC2_155 DNRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTL TH_4458|M.thermoresistible__bu ----------------------------------STSTPKGVVLTHHNLL MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NVLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVA Mvan_0269|M.vanbaalenii_PYR-1 DVLSRLAAQHNQQRSSQSITNDRYEIRWEQSAAALSGAETDEVSSWILVG Mflv_0405|M.gilvum_PYR-GCK DVLNRLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVG MSMEG_0408|M.smegmatis_MC2_155 RVLNKLAARHNQQRSTHVDPDARYEIRWDAIAS--AAASTGAAADWILVG TH_4458|M.thermoresistible__bu ANLESISRDAGQGDEARVVSWLPLHHDMGLIGGIFGVVHFGGTAYLMPPS MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DAAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALR Mvan_0269|M.vanbaalenii_PYR-1 DDTEATRPLVDVLSARGQRYRIFGLPVSDADEEQLGEALRLAAAEDSTLR Mflv_0405|M.gilvum_PYR-GCK DDTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLR MSMEG_0408|M.smegmatis_MC2_155 DDTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELY TH_4458|M.thermoresistible__bu SFIQRPMSWLEAISWHGANISVGPNFGYQLCVERSTPEERATLDLSTWVR MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IVHVAALAGQ----GSSSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIW Mvan_0269|M.vanbaalenii_PYR-1 IVHVGGLDSDPDPGTAPSMRSLLRMQHRILGGTRRLFRAAAAAELRTPIW Mflv_0405|M.gilvum_PYR-GCK IVHVAALDAA---ESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMW MSMEG_0408|M.smegmatis_MC2_155 VVHIAAGDGA-----AAPMRDLLRVQHRTLGGLRRLFRAANDAELRSPIW TH_4458|M.thermoresistible__bu AYCGAEPVRAATMRRFTEAFAPAGFRADAFHPVYGLAEATLFVSGRPENV MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDE Mvan_0269|M.vanbaalenii_PYR-1 VVTRRAQHVTATDTVAPDQSCLWGFGRAAALELPQLWGGLADLADGTADE Mflv_0405|M.gilvum_PYR-GCK LVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDE MSMEG_0408|M.smegmatis_MC2_155 LVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSG-ADTE TH_4458|M.thermoresistible__bu LPTVRSLDNAALREHRVVPAAADDANAAAVVGCGPAAYGEEIVIVDPATR MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSD Mvan_0269|M.vanbaalenii_PYR-1 WSRLLNRITAPHGPAVREDQIALRDHAVYVPRLVRRAGRPAGKPLQLRDD Mflv_0405|M.gilvum_PYR-GCK WSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRAD MSMEG_0408|M.smegmatis_MC2_155 WPRLIARITSPRD---GEDQIALRGDAVYAPRLVRRTGEPSDTPLPVRED TH_4458|M.thermoresistible__bu REFPPDVVGEIWVAGENVAQGYLGKPSESAETFAAHLADSGRGPFLRTGD MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDALAAQ Mvan_0269|M.vanbaalenii_PYR-1 ATYLVTGGLGSIGLEIAGYLAAHGARHLVLTSRRAPGDATQQRIDALGAQ Mflv_0405|M.gilvum_PYR-GCK ATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEALRER MSMEG_0408|M.smegmatis_MC2_155 RTYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQ TH_4458|M.thermoresistible__bu YGFLLDG------------------------ELFVTGRLKDLIIIRGRNY MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 G-CEVRAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDL Mvan_0269|M.vanbaalenii_PYR-1 HSCQIRVVAADVADAHDVARLLAAVAAELPPLAGIVHAAGEIGTTPLVSL Mflv_0405|M.gilvum_PYR-GCK HGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADL MSMEG_0408|M.smegmatis_MC2_155 YACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGL TH_4458|M.thermoresistible__bu HPNDIEATVQEVHPALMSGRGAAFAVSPDPSGTEQLVIVQEVDRGRLGEV MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTA Mvan_0269|M.vanbaalenii_PYR-1 EDSEVDRVFAGKVWGAWHLSEAAADLQ--LDFFLGTSSIASVWGGYGQTA Mflv_0405|M.gilvum_PYR-GCK DDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWGGFGQAA MSMEG_0408|M.smegmatis_MC2_155 DDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTA TH_4458|M.thermoresistible__bu DTDELIAAIRTAVTSQHDIGVHTVVLVDPLRIPTTSSGKIRRRTCRQRFL MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 YSAANAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKT Mvan_0269|M.vanbaalenii_PYR-1 YGAANAFLDGLAWRLREQGISGVSINFGPWSAGMADAESRARLDQRGVRT Mflv_0405|M.gilvum_PYR-GCK YGAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKT MSMEG_0408|M.smegmatis_MC2_155 YGAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRT TH_4458|M.thermoresistible__bu DGELDAFAEWRLATPRPAQPVPAADEQADEQAGAGPGAGPGADEIRAWFV MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LSPTDALAGLADVVAASGS-NAVQGVIARIDWARFLPLYQQAGKRGFLAE Mvan_0269|M.vanbaalenii_PYR-1 LSPADALAGLADVVTAAEAPGPAQGIVARIDWERFLPLYQQAGRRAFLAE Mflv_0405|M.gilvum_PYR-GCK LSPADALAGLSDAVISAAP----HPVVARVDWSRFLPLYQQAGRRGFLAE MSMEG_0408|M.smegmatis_MC2_155 LSPAEALAGMADVVAGPVQ-----GVVAKIDWSRFLPLYQQAGRRAFLSE TH_4458|M.thermoresistible__bu AQLAGELG------------------------------------------ MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LDREVPSHLAGV--AGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAE Mvan_0269|M.vanbaalenii_PYR-1 LEREVPDTAP----AATPSGRTELVERLTNAPVQQRKKLLTDYLRTAVAE Mflv_0405|M.gilvum_PYR-GCK LERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAE MSMEG_0408|M.smegmatis_MC2_155 LESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAE TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ---------------------------------------MTASVEGADQK MAB_0939|M.abscessus_ATCC_1997 VTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPR Mvan_0269|M.vanbaalenii_PYR-1 ITRVDATEIREDAGFFDLGMDSLMAVELRRRIEQGVGREIPATLAMDHPR Mflv_0405|M.gilvum_PYR-GCK VTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPR MSMEG_0408|M.smegmatis_MC2_155 VTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPR TH_4458|M.thermoresistible__bu ---LSPDDIDTGQPFAYYGLDSVRAIQLMTALEAWSGIKVAPTLAYDHPT MUL_1655|M.ulcerans_Agy99 ----------MMSRATSLR------------RQHGDGDQEFASAVAIIGV MMAR_2473|M.marinum_M -----------MSRATSLR------------RQHGDGDQEFASAVAIIGV Mb1692|M.bovis_AF2122/97 ---------------------------------------MQPTGIAIIGL Rv1664|M.tuberculosis_H37Rv ---------------------------------------MQPTGIAIIGL MAV_3107|M.avium_104 ---------------------------------------MPPTDVAIIGM MLBr_00135|M.leprae_Br4923 SEKLISYLKKVVVELDETR------------ARLREYEQRATEPVAVVGI MAB_0939|M.abscessus_ATCC_1997 ISDVADYLLGDVLGLAEQA--K------PAAQLASAVTGRTDEPIAIVAV Mvan_0269|M.vanbaalenii_PYR-1 LSDVADYLLGEVLGLAEQAPAK------AGSQPASAAANRTDEPIAIVAV Mflv_0405|M.gilvum_PYR-GCK LSDAADYLLGDVLGLTEAA---------TAPKAATVVSTAADEPIAIVAV MSMEG_0408|M.smegmatis_MC2_155 LSDAADYLLVEVLGLGEQT----------NVRQASTVTARTDDPIAVVAV TH_4458|M.thermoresistible__bu IDLAAEHLAGLTHTATSTAADAGVSTGAGRRPEHGPAPDRADEPIAIIGI :*::.: MUL_1655|M.ulcerans_Agy99 ACRIPG-AANPGEFWELVSEGHEVA------------------------- MMAR_2473|M.marinum_M ACRFPG-AANPGEFWELVSEGHEVA------------------------- Mb1692|M.bovis_AF2122/97 ACRFPT-VVSPGDLWDLLRDGREAT------------------------- Rv1664|M.tuberculosis_H37Rv ACRFPT-VVSPGDLWDLLRDGREAA------------------------- MAV_3107|M.avium_104 ACRFPG-APDPGSFWRLLRDGREVT------------------------- MLBr_00135|M.leprae_Br4923 GCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKT MAB_0939|M.abscessus_ATCC_1997 SCRFPG-APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVAGKT Mvan_0269|M.vanbaalenii_PYR-1 SCRFPG-APDPEAFWEVLAGGVDAIREVPEDR-FDIDEFYDPDPDAAGKT Mflv_0405|M.gilvum_PYR-GCK SCRFPG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGKT MSMEG_0408|M.smegmatis_MC2_155 SCRFPG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGKT TH_4458|M.thermoresistible__bu GCRFPG-ADGPAAYWRLLREGRDAITATPPER----------WDTDSVGD .**:* . .* * :: :. MUL_1655|M.ulcerans_Agy99 -----KPIDHVGDFDAEFFNVSPREATAMDPRQRLALELAWELFEDARIV MMAR_2473|M.marinum_M -----KPIDHVGDFDAEFFNVSPREAAAMDPRQRLALELAWELFEDARIV Mb1692|M.bovis_AF2122/97 -----GSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVV Rv1664|M.tuberculosis_H37Rv -----GSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVV MAV_3107|M.avium_104 -----RFAGEAAEFDADFFNLSPREAAAMDPRQRLALELAWELLEDAFIV MLBr_00135|M.leprae_Br4923 YTRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGID MAB_0939|M.abscessus_ATCC_1997 YTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYS Mvan_0269|M.vanbaalenii_PYR-1 YTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGLA Mflv_0405|M.gilvum_PYR-GCK YTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYA MSMEG_0408|M.smegmatis_MC2_155 YTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYA TH_4458|M.thermoresistible__bu GTRWGGFLERIDGFDAGFFGISPREAVRIDPQQRLLLEVAWEALEDAGLV **. **.::* *. ::*:*** ** ** :* * MUL_1655|M.ulcerans_Agy99 AESVRGEPIAVYLGAMNDDYALLTLDQAPDKLDHYSFAGASRGMIANRVS MMAR_2473|M.marinum_M AESVRGEPIAVYLGAMNDDYALLTLDQAPDKLDHYSFAGASRGMIANRVS Mb1692|M.bovis_AF2122/97 PETLRGQPIAVYLGAMNDDYAVLTL--AADRVDHHAFAGTSRAIIANRVS Rv1664|M.tuberculosis_H37Rv PETLRGQPIAVYLGAMNDDYAVLTL--AADRVDHHAFAGTSRAIIANRVS MAV_3107|M.avium_104 AETLRGEAVSVYLGAMTDDYAALTLRDVPDNVDHHTFTGVSRGMIANRIS MLBr_00135|M.leprae_Br4923 PLSLRGSATGVFTGIFAPSYGSRDT----GGLQGYGLTGTAVSVASGRVS MAB_0939|M.abscessus_ATCC_1997 PAALRGSRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRVA Mvan_0269|M.vanbaalenii_PYR-1 PADLRGSRTGIFVGVAANEYAHLLSSESIEKIEPHFITGNALNAISGRVA Mflv_0405|M.gilvum_PYR-GCK PSALRGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVA MSMEG_0408|M.smegmatis_MC2_155 PSDLRGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVA TH_4458|M.thermoresistible__bu PDRLAGSRTGVFTGVSTYDYLHLQLS-HPELIDAYSGTGTASSIAANRLS . : *. .:: * .* :: : :* : :.*:: MUL_1655|M.ulcerans_Agy99 SGFALHGPSMTVDCGQSSSLVAVHLAPGYLRGAGDATMAIAGGIHLNLAS MMAR_2473|M.marinum_M YGFALHGPSMTVDCGQSSSLVAVHLAREYLRGAGDATMAIAGGIHLNLAS Mb1692|M.bovis_AF2122/97 FAFGLRGPSVTIDSGQSSSLVAVHLACESVR-TGEAPLAIAGGVHLNLAR Rv1664|M.tuberculosis_H37Rv FAFGLRGPSVTIDSGQSSSLVAVHLACESVR-TGEAPLAIAGGVHLNLAR MAV_3107|M.avium_104 YLLGLRGASMTVDSGQSSSLVAVHLGCESVR-SGQAPLAIAGGVHLNLAD MLBr_00135|M.leprae_Br4923 YVLGLEGPAVSVDTACSSSLVAIHWAMSSLR-SGECDLALAGGVTVMGLP MAB_0939|M.abscessus_ATCC_1997 FALGFEGPAVAVDTACSSALVAVHQAVQALH-SGDCDLALAGGVNVLLSP Mvan_0269|M.vanbaalenii_PYR-1 FALGLEGPAVAVDTACSSALVAVHQACQALH-SGDCDLALAGGVNVLLSP Mflv_0405|M.gilvum_PYR-GCK FALGLEGPAVAVDTACSSSLVAVHQATQALR-SGDCDMALAGGVNVLLSP MSMEG_0408|M.smegmatis_MC2_155 FALGFEGPAVAVDTACSSALVAVHQACQALQ-SGDCDLALAGGVNVLLSP TH_4458|M.thermoresistible__bu YVFDFRGPSLTLDSACSSSLVAVHQACRSLR-DGECDLALAGGVNIMLSA : :.*.::::* . **:***:* . :: *:. :*:***: : MUL_1655|M.ulcerans_Agy99 ETGRLETEFGAVSASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDGN MMAR_2473|M.marinum_M ETGRLETEFGAVSASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDGN Mb1692|M.bovis_AF2122/97 ETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGD Rv1664|M.tuberculosis_H37Rv ETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGD MAV_3107|M.avium_104 EIALLEREFGAVSVSGHTYAFDRRADGYVRGEGGGLVLLKPLAAARRDGD MLBr_00135|M.leprae_Br4923 SIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGH MAB_0939|M.abscessus_ATCC_1997 VTVIAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGD Mvan_0269|M.vanbaalenii_PYR-1 VTSVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLGDAVRDGD Mflv_0405|M.gilvum_PYR-GCK VTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGD MSMEG_0408|M.smegmatis_MC2_155 VTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGD TH_4458|M.thermoresistible__bu GIGLNFTRAGVMATDGRCKTFDARADGWVRGEGAGIVVLKPLREALADED . :: *: :* *** .:* *:::*: : * . MUL_1655|M.ulcerans_Agy99 SIRAVILGEAVGSAGHTAGGLAAPSAAAEADVMRRAMASAGVDPNQIDYI MMAR_2473|M.marinum_M RIRAVILGAAVGSAGHTAGGLAAPSAAAEADVMRRAMASAGVDPNQIDYI Mb1692|M.bovis_AF2122/97 RIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYV Rv1664|M.tuberculosis_H37Rv RIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYV MAV_3107|M.avium_104 RIHAVIRATAVGNAGHGAPAQTLPSAAAEADVIGRALAEAGLGGADIDYV MLBr_00135|M.leprae_Br4923 TVLAVVRGSAVNQDGASN-GLTAPNGLAQQRVIQAALTNAGLSSADVDVV MAB_0939|M.abscessus_ATCC_1997 RVLAVIPGSAVNQDGASS-GLTVPNGGAQQRLIGSVLARAGLVGGDVDYL Mvan_0269|M.vanbaalenii_PYR-1 RVCAVIPSSAVNQDGASS-GLTVPNGGAQQRLIGMALARAGLSGGDVDYL Mflv_0405|M.gilvum_PYR-GCK RVCAVIAGSAVNQDGASS-GLTVPNGGAQQRLIGTVLARAGITGGEVDYL MSMEG_0408|M.smegmatis_MC2_155 RVCAVIPASSVNQDGASS-GLTVPNGGAQQRLIEATLARAGLSGADVDYL TH_4458|M.thermoresistible__bu PIYAVIRGSAVNQDGRTN-GLMAPSRTAQEVVLTDAYRRAGVSPGVVQYV : *:: . :*.. * . *. .: :: . **: :. : MUL_1655|M.ulcerans_Agy99 EAHGTGTRIGDTTEAQALSEVFATR---ETPVWLGSVKSNIGHTGAAAGA MMAR_2473|M.marinum_M EAHGTGTRIGDTTEAQALSEVFATR---ETPVWLGSVKSNIGHTGAAAGA Mb1692|M.bovis_AF2122/97 EAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGI Rv1664|M.tuberculosis_H37Rv EAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGI MAV_3107|M.avium_104 EAHGTGTRVGDAVETQALGRIFAERS--HHPVSVGSVKTNIGHAASAAGI MLBr_00135|M.leprae_Br4923 EAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAGV MAB_0939|M.abscessus_ATCC_1997 EAHGTGTPLGDPIEVQAAAAAYGGSRDADRPLLMGSVKSNIGHTESASGA Mvan_0269|M.vanbaalenii_PYR-1 EAHGTGTPLGDPIEVQAAAAAYGASRDADRPLLMGSVKTNIGHLESASGA Mflv_0405|M.gilvum_PYR-GCK EAHGTGTPLGDPIEVQAAAAAYAGARDADRPLLMGSVKTNIGHTESASGA MSMEG_0408|M.smegmatis_MC2_155 EAHGTGTPLGDPIEVQAAAAAYGAGRDADRPLLMGSVKTNIGHTESASGA TH_4458|M.thermoresistible__bu EAQGIGTPVGDAIEVGALGTVLAEDRPPDSPCLIGSVKTNIGHLEAAAGI **:* .* :**. *. * . * :**:*:*:** .*:* MUL_1655|M.ulcerans_Agy99 AGLIKTVLSLENGAIPASLNFVGDSAGTDMESHGLHVSTTLTPWPRGAGP MMAR_2473|M.marinum_M AGLIKTVLSLENGAIPASLNYVGDSAGTDMESHGLHVSTTLTPWPRGAGP Mb1692|M.bovis_AF2122/97 AGLLKAVLAIENAVIPPSLNYVG--APIDLDSLGLRVDTALTPWPVADEP Rv1664|M.tuberculosis_H37Rv AGLLKAVLAIENAVIPPSLNYVG--AAIDLDSLGLRVDTALTPWPVADEP MAV_3107|M.avium_104 AGLLKAVLAIEHAAIPPNLHFERPDPDIDLNRLGLRVNTALAPWPDRGGP MLBr_00135|M.leprae_Br4923 AGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVEGRP MAB_0939|M.abscessus_ATCC_1997 AGLIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQANGRP Mvan_0269|M.vanbaalenii_PYR-1 AGLIKVVLSLQHNLLPQSLHFENPSPHIPWDSLPVRVVDKAIPWQADGRP Mflv_0405|M.gilvum_PYR-GCK AGLIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQPNGRP MSMEG_0408|M.smegmatis_MC2_155 AGLIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQTNGRV TH_4458|M.thermoresistible__bu AGLIKVALALRHRMIPPTLNFTEPNPTIEFDKLPVRVAQTLTPWPDDSGR **::* . ::.: :* .*: . : * * MUL_1655|M.ulcerans_Agy99 RRAGVSSFGMGGTNAHVIVQQAPIP--------------QEAVADPDGTE MMAR_2473|M.marinum_M RRAGVSSFGMGGTNAHVIVQQAPIP--------------QEAVADPDGTE Mb1692|M.bovis_AF2122/97 RRAGVSSFGMGGTNAHVILEQGPTQSPEI---------VESVAAAGSNAP Rv1664|M.tuberculosis_H37Rv RRAGVSSFGMGGTNAHVILEQGPTQSPEI---------VESVAAAGSNAP MAV_3107|M.avium_104 RRAGVSSFGMGGTNAHVIVEQDAAQ--------------QNPTPASAPAD MLBr_00135|M.leprae_Br4923 RRAGVSSFGISGTNAHVILEEAPTP---V---------EASYSTADQQRL MAB_0939|M.abscessus_ATCC_1997 RRAGVSSFGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQSA Mvan_0269|M.vanbaalenii_PYR-1 RRAGVSSFGFTGTNAHVLIEEAPLPQAAD----------PVEEPDT-RAL Mflv_0405|M.gilvum_PYR-GCK RRAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPA MSMEG_0408|M.smegmatis_MC2_155 RRAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTDD TH_4458|M.thermoresistible__bu AVAGVSAFGFGGTNAHVVLAEAPQVR-------------AAATADDHADG ****:**: ******:: : . . MUL_1655|M.ulcerans_Agy99 ATVPWLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTRSVFEH MMAR_2473|M.marinum_M ATVPWLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTRSVFEH Mb1692|M.bovis_AF2122/97 VAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDH Rv1664|M.tuberculosis_H37Rv VAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDH MAV_3107|M.avium_104 VALPWVLSARSERALALQAQRLSAHLAERPQASPLDVGWSLVSARAVFEH MLBr_00135|M.leprae_Br4923 SVVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALA-ARSVFEH MAB_0939|M.abscessus_ATCC_1997 PVSVLPLSARSPEALAAVAQRYESWLAAHPDVDLEDVCLTAGRGRSHFEH Mvan_0269|M.vanbaalenii_PYR-1 PVGVLALSARSPEALTALAQRYEAWLSAHPDADLADVCRTAGTGRSHFEH Mflv_0405|M.gilvum_PYR-GCK PVEVLPLSARSPEALVALAQRYETWLTAHPEADLADVCRTAGTGRSHFEH MSMEG_0408|M.smegmatis_MC2_155 SPQVLALSARSPEALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFEY TH_4458|M.thermoresistible__bu FVEILPLSARSQAALDALAERYESALTG--GVPPADLCHTAGARRAHHDH ::.** ** * * : *: : *: .:: MUL_1655|M.ulcerans_Agy99 RAVLVGGDRGGFMAGLAALASGEPGVNLVAGRAGSGGKT--VLVFPGQGA MMAR_2473|M.marinum_M RAVLVGGDRGGFMAGLAALASGEPGVNLVAGRAGSGGKT--VLVFPGQGA Mb1692|M.bovis_AF2122/97 RAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKT--VFVFPGQGS Rv1664|M.tuberculosis_H37Rv RAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKT--VFVFPGQGS MAV_3107|M.avium_104 RAVLVGCERGVLATGLAGVASGRPDAATVVGRARATGKT--VLVFPGQGS MLBr_00135|M.leprae_Br4923 RAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKT--VVVFPGQGA MAB_0939|M.abscessus_ATCC_1997 RAALVVDSIQTAREGLLELAQNRLRPGVVRGEHTNHPTT--AWLFTGQGS Mvan_0269|M.vanbaalenii_PYR-1 RAALVVDSVAAAREGLAELAQNRLRPGVVRGEHTHHPTT--AWLFTGQGS Mflv_0405|M.gilvum_PYR-GCK RAALVVDSVESARIALTDLAQNRLRPGVVRGEHLNHPTT--AWMFTGQGS MSMEG_0408|M.smegmatis_MC2_155 RAALVVDSVERAREGLAALAEGRTPAGVVRGEHVHRPTT--AWLFTGQGS TH_4458|M.thermoresistible__bu RLAVVGASRAELIGALAAYRRGEPHPGVFTGRSQSGHRSGVVFVFSDEGS * .:* . .* .. *. : . :*..:*: MUL_1655|M.ulcerans_Agy99 QWLGMGRDLYGRFPAFAKAFDTVADALDEHLRLPLREVIWGAD------- MMAR_2473|M.marinum_M QWLGMGRDLYGRFPAFAKAFDTVADALDEHLRLPLREVIWGAD------- Mb1692|M.bovis_AF2122/97 QWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGAD------- Rv1664|M.tuberculosis_H37Rv QWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGAD------- MAV_3107|M.avium_104 QTLGMGRQLYERFVVFARALDEAVAVVDEHSRLSVREVMWGAD------- MLBr_00135|M.leprae_Br4923 QRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGAD------- MAB_0939|M.abscessus_ATCC_1997 QYPGMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGKA Mvan_0269|M.vanbaalenii_PYR-1 QFPGMARELFETEPVFADAVTRCADAVKDILPRPLLEVLFAADRESG--- Mflv_0405|M.gilvum_PYR-GCK QYPGMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVPP MSMEG_0408|M.smegmatis_MC2_155 QYPGMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRETA--- TH_4458|M.thermoresistible__bu QWRGMAQRLYAEDQVFRTALAECDRALRRHMEISPLSELLADPS------ * **.: * .* . : . . : . MUL_1655|M.ulcerans_Agy99 ASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEISAAHVAG MMAR_2473|M.marinum_M ASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEISAAHVAG Mb1692|M.bovis_AF2122/97 AGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAG Rv1664|M.tuberculosis_H37Rv AGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAG MAV_3107|M.avium_104 PELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAG MLBr_00135|M.leprae_Br4923 AGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAG MAB_0939|M.abscessus_ATCC_1997 GEALRHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAG Mvan_0269|M.vanbaalenii_PYR-1 -EALRHTSFAQPAIFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAG Mflv_0405|M.gilvum_PYR-GCK TETLRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAG MSMEG_0408|M.smegmatis_MC2_155 -DLLQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAG TH_4458|M.thermoresistible__bu HSRMDEVTIASPALFAVQVALAALWQSWGVEPAAVIGHRMGEVAAAHVAG : . :*.**:*..::.* : : .: . *:** :*: :** *** MUL_1655|M.ulcerans_Agy99 VLSLTDAARLVSARGRLMAQLPPGGVMVAVAASAAQVAPMLQEG--VSIA MMAR_2473|M.marinum_M VLSLTDAARLVSARGRLMAQLPPGGVMVAVAASAAQVAPMLEEG--VSIA Mb1692|M.bovis_AF2122/97 ALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEG--VCIA Rv1664|M.tuberculosis_H37Rv ALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEG--VCIA MAV_3107|M.avium_104 VLSLRDAARLVAARGALMAALPPGGVMVAVTATEAQVAPLVGGG--VSIA MLBr_00135|M.leprae_Br4923 VLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEG--VGIA MAB_0939|M.abscessus_ATCC_1997 VFSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFPRVSVG Mvan_0269|M.vanbaalenii_PYR-1 VFSLEDGARLMAERGRMFGSLPEGGRMVAVFTDAKLVEEIAGDFPRVSVG Mflv_0405|M.gilvum_PYR-GCK VFSLEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFPRVSVG MSMEG_0408|M.smegmatis_MC2_155 VFSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPRVSVG TH_4458|M.thermoresistible__bu VLGLDDAAALLCGRTRLSRLASTG-------------------------- .:. *.* :: * : . * MUL_1655|M.ulcerans_Agy99 AVNGPDSVVISGPEAATAVVADRLTGQGCRAHRLAVSHAFHSALMEPMMV MMAR_2473|M.marinum_M AVNGPDSVVISGPEAATAVVADRLTGQGCRAHRLAVSHAFHSALMEPMMA Mb1692|M.bovis_AF2122/97 AVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVE Rv1664|M.tuberculosis_H37Rv AVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVE MAV_3107|M.avium_104 AVNGPDAVVLSGEQEAVSAVAERLAGSGARVHRLAVSHAFHSALMEPMLD MLBr_00135|M.leprae_Br4923 AINAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLE MAB_0939|M.abscessus_ATCC_1997 AYNGPN-TVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILD Mvan_0269|M.vanbaalenii_PYR-1 AYNGPN-TVLSGPGEDLEQIVDRFGDDGVRCTWLQTSHAFHSELLDPVLD Mflv_0405|M.gilvum_PYR-GCK AYNGPN-TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLD MSMEG_0408|M.smegmatis_MC2_155 AYNGPN-TVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLD TH_4458|M.thermoresistible__bu ----------------------------------------------AVRE .: MUL_1655|M.ulcerans_Agy99 QFGATISGIVAHEPRIALVSNMTG-QLAAAGYGTASYWVEHVRKPVRFAD MMAR_2473|M.marinum_M QFGATISGIVAHEPRIALVSTMTG-QLAAAGYGTASYWVEHVRKPVRFAD Mb1692|M.bovis_AF2122/97 EFSKVLADVCVRAPRIGLVSNVTG-QLAGAGYGSPAYWVEHVRKPVRFFD Rv1664|M.tuberculosis_H37Rv EFSKVLADVCVRAPRIGLVSNVTG-QLAGAGYGSPAYWVEHVRKPVRFFD MAV_3107|M.avium_104 GFAAAAAGIEPRPPRIPLVSNLTG-QLAGPGYGTPQYWVEHVRRPVRFVD MLBr_00135|M.leprae_Br4923 EFVRVAAQVEVRKPQIGLVSNVTG-ELAGPDFGSPQYWGEHVSRAVRFVD MAB_0939|M.abscessus_ATCC_1997 EFESYAAQVQFAAPTLPLVCNRTGAVLTAQTPIDGQYWRRHSRQPVQFAE Mvan_0269|M.vanbaalenii_PYR-1 EFESYAAQFQFATPTLPLVCNRTGTVLTAQTPLDAQYWRRHSRQPVQFAE Mflv_0405|M.gilvum_PYR-GCK EFESYAAQLQFAAPTLPLVCNRTGAVLTGQTSLDAQYWRRHSRQPVQFAE MSMEG_0408|M.smegmatis_MC2_155 EFEAYAAQFQFAAPTLPLVCNRTGAVLTGQTPLDAQYWRRHSRQPVQFAE TH_4458|M.thermoresistible__bu GLDGLLANLRPDDPRIPLYSTVTGDAVTGRGFG-AAHWMENLHSPVRFSA : : . * : * .. ** ::. :* .: .*:* MUL_1655|M.ulcerans_Agy99 GVALAESLGAATFLETGPSAGLGTSV--------------ALLAKGRPEV MMAR_2473|M.marinum_M GVALAESLGAATFLETGPSAGLGTSV--------------ALLAKGRPEV Mb1692|M.bovis_AF2122/97 GVGLAESLGARVFVEVGPGAGLEASV--------------ALLARDRPEV Rv1664|M.tuberculosis_H37Rv GVGLAESLGARVFVEVGPGAGLEASV--------------ALLARDRPEV MAV_3107|M.avium_104 GVRLAESQGAGVFLEVGPGAALTAAVDQSLSTEGAT--AIATLPKDRPET MLBr_00135|M.leprae_Br4923 SARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAV--VVSMMGKDRPEL MAB_0939|M.abscessus_ATCC_1997 SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPPRAIVSLRKGVEDR Mvan_0269|M.vanbaalenii_PYR-1 SVRTVAALGCSVLMEIGPQPVLTGSAVQVWPEHLAAPRAIVSLRKGVSDR Mflv_0405|M.gilvum_PYR-GCK SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAPRAIASLRKGVADR MSMEG_0408|M.smegmatis_MC2_155 SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAPRAVASLRKGVADR TH_4458|M.thermoresistible__bu AVRRLLGRGHDAFLEISAHPMLLSAVQEDAADLGRSCTTLVSMRRGECGR .. * ::* .. . * : : :. MUL_1655|M.ulcerans_Agy99 ESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTYSFARQRFWLG---- MMAR_2473|M.marinum_M ESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTYSFARQRFWLG---- Mb1692|M.bovis_AF2122/97 ESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLG---- Rv1664|M.tuberculosis_H37Rv ESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLG---- MAV_3107|M.avium_104 ESALHAAGHLFTRGHRLDWAGVFAGLPARRVDLPTYAFARERFWLGGASL MLBr_00135|M.leprae_Br4923 ASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPG-- MAB_0939|M.abscessus_ATCC_1997 RQIADALASAYVSGHRPNFAALQR-HPRRTVELPTYPFQRRRFWPKSSG- Mvan_0269|M.vanbaalenii_PYR-1 RQITEALAAAYVGGHRPDFGALYR-RPGRAVALPTYPFQRRRFWPKTSG- Mflv_0405|M.gilvum_PYR-GCK RQIADALAAAYIGGHKPDFAALHE-QRGVRLELPTYPFQRRRFWPKSAG- MSMEG_0408|M.smegmatis_MC2_155 RQIADALASAYVGGHRPDFAAVHR-QPRRPVELPTYPFQRRRFWPKASS- TH_4458|M.thermoresistible__bu DVLMTSLAALYASGHAVDWARVHP-HGSHCTAAPTYPWQRQRFWLDIDR- . . : * :: *** : *.*** MUL_1655|M.ulcerans_Agy99 ----EGAGRKAD----------SSDESGLRPRLDSVDS------------ MMAR_2473|M.marinum_M ----EGAGRKAD----------SSDESGLRPRLDSVDS------------ Mb1692|M.bovis_AF2122/97 ---DNGELSVDQ----------TGKDAGAIARLQSLAP------------ Rv1664|M.tuberculosis_H37Rv ---DNGELSVDQ----------TGKDAGAIARLQSLAP------------ MAV_3107|M.avium_104 AGAPAGAAPVGG----------GTRAPELAHRLHALPR------------ MLBr_00135|M.leprae_Br4923 ---TDGTASVSG----------LGLGSTEHALLGAVVERPDSGGVVLTGR MAB_0939|M.abscessus_ATCC_1997 TAIEGGGGLPSG--ILGRGEDLASGDSVYISRLSVRSQPWLSDHVIYG-- Mvan_0269|M.vanbaalenii_PYR-1 ITTDG--PAVSG--ILGSAKDLASGDTVYTSRWSVRSQPWLADHVIYG-- Mflv_0405|M.gilvum_PYR-GCK MAIDGRVGASAGSGILGSGKDLASGDSVYTSRLSVKTQPWLSDHVIYG-- MSMEG_0408|M.smegmatis_MC2_155 IAVDGG-TAASG--ILGSGKDLASGDTIYTSRLSVKSQPWLADHVIYG-- TH_4458|M.thermoresistible__bu --CDTGDGAGTG---------GTAERTVVPAPLPAPSAS----------- . MUL_1655|M.ulcerans_Agy99 ---------------------------------KERFRQLVDLVCLHAAI MMAR_2473|M.marinum_M ---------------------------------KERFRQLVDLVCLHAAI Mb1692|M.bovis_AF2122/97 ---------------------------------PELQRQLVELVCFHAAI Rv1664|M.tuberculosis_H37Rv ---------------------------------PELQRQLVELVCFHAAI MAV_3107|M.avium_104 ---------------------------------DEQQRVLRELVCEHAAA MLBr_00135|M.leprae_Br4923 LSLANQPWLADHVIGGVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPL MAB_0939|M.abscessus_ATCC_1997 ------------------TVVVPGATYAAMALAAVGTPARAKDVFFYEPI Mvan_0269|M.vanbaalenii_PYR-1 ------------------TVVVPGATYAAMALAAVGTPARVKDVFFYEPI Mflv_0405|M.gilvum_PYR-GCK ------------------TVVVPGATYAAMALAAVGTPAHAKDVFFYEPI MSMEG_0408|M.smegmatis_MC2_155 ------------------TVVVPGATYAAMALAAVGTPARLKDVFFYEPI TH_4458|M.thermoresistible__bu --------------------AAPTVDEVLLCADQRERRELLESYLRDRVA . MUL_1655|M.ulcerans_Agy99 ATGHSNSHQIDAERAFQGLG------------------------------ MMAR_2473|M.marinum_M VTGHSNSHQIDAERAFQDLG------------------------------ Mb1692|M.bovis_AF2122/97 VLGRKSSHDIDPECAFQDLG------------------------------ Rv1664|M.tuberculosis_H37Rv VLGRKSSHDIDPECAFQDLG------------------------------ MAV_3107|M.avium_104 VLGHPGGDAIDPDRAFADLG------------------------------ MLBr_00135|M.leprae_Br4923 VLHPGSGVQVQVVVAAADESSRRAVSVYSRGDQSHGGWLLNAEGLLEVDA MAB_0939|M.abscessus_ATCC_1997 ILPEKSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSLNAEGTVVTG Mvan_0269|M.vanbaalenii_PYR-1 ILPEKASREVQLTLHPSEDG-GQKFQVHSREYGERGTEWSLNAEGTVASG Mflv_0405|M.gilvum_PYR-GCK ILPEKSSREVQLTVHPSVDG-ESKFQVHSRPYGERGAEWALNAEGVVASG MSMEG_0408|M.smegmatis_MC2_155 ILPEKASREVQLTLHPADGGSVLSFQIHSRPYGERGADWSLNAEGTVDTA TH_4458|M.thermoresistible__bu AELGVLPPLLDVAAPLSTLG------------------------------ :: . MUL_1655|M.ulcerans_Agy99 -------------------------------------FESMTGVELRNR- MMAR_2473|M.marinum_M -------------------------------------FESMTGVELRNR- Mb1692|M.bovis_AF2122/97 -------------------------------------FDSMSGVELRNR- Rv1664|M.tuberculosis_H37Rv -------------------------------------FDSMSGVELRNR- MAV_3107|M.avium_104 -------------------------------------FDSLIGVELRNR- MLBr_00135|M.leprae_Br4923 AEATVDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQGLVAIWRRGSE MAB_0939|M.abscessus_ATCC_1997 IGDDAEPAPE----AAEPAEPVDAAIERMERMRPMELFEIFADLELAWGP Mvan_0269|M.vanbaalenii_PYR-1 VDENPQ---------AEPSGPVDEAIERLNRMRPQDLFETFADMELAWGP Mflv_0405|M.gilvum_PYR-GCK VGDSPAAAG-------DLEDPVDEAIERLNRMRPQELFETFADLELAWGP MSMEG_0408|M.smegmatis_MC2_155 GSDPDAAAD-------EQSDPVDEVIERLERMRPQDLFETFADLELAWGP TH_4458|M.thermoresistible__bu -------------------------------------IDSLTAAELRAR- :: : MUL_1655|M.ulcerans_Agy99 ----------------------LRAVT---GLALSRT------------- MMAR_2473|M.marinum_M ----------------------LRAVT---GLALSRT------------- Mb1692|M.bovis_AF2122/97 ----------------------LQMAIGLPGLSLPRT------------- Rv1664|M.tuberculosis_H37Rv ----------------------LQMAIGLPGLSLPRT------------- MAV_3107|M.avium_104 ----------------------LTTHT---GTALSRT------------- MLBr_00135|M.leprae_Br4923 LFAEVVAPTGVVVDGMGMHPALLDAVLHALGLAIENTQATTEMRLPFCWR MAB_0939|M.abscessus_ATCC_1997 TWSG-----------------SLKSLWLGEGEAIGDVLVGEELAEQLGTE Mvan_0269|M.vanbaalenii_PYR-1 TWSG-----------------SLKSLWLGEGEAIGDILVGEELAEQLGTE Mflv_0405|M.gilvum_PYR-GCK TWSG-----------------SLKSLWLGEGEAIGDILVGAELAEQLGTE MSMEG_0408|M.smegmatis_MC2_155 TWSG-----------------SLKSLWLGDGEAVGDILVGAELAEQLGSE TH_4458|M.thermoresistible__bu -------------------------VERDLGIVIPVA------------- * : MUL_1655|M.ulcerans_Agy99 -------------IIFDYTTPMALARHLDE-------------------- MMAR_2473|M.marinum_M -------------IIFDYPTPMALARHLDE-------------------- Mb1692|M.bovis_AF2122/97 -------------LIFDYPTASALAECLG--------------------- Rv1664|M.tuberculosis_H37Rv -------------LIFDYPTASALAECLG--------------------- MAV_3107|M.avium_104 -------------LIFDYPTPAALADHLRQ-------------------- MLBr_00135|M.leprae_Br4923 GVSLHAGGAGRVRARFTSAGADAIAVDIADSAGLPVL------------- MAB_0939|M.abscessus_ATCC_1997 PMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRF Mvan_0269|M.vanbaalenii_PYR-1 PMHPVLMDLCTGVAFPAFPALLAAEQGVSDLFLPLRYGQVTLRDKMPRRF Mflv_0405|M.gilvum_PYR-GCK PMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRF MSMEG_0408|M.smegmatis_MC2_155 PMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLAEKMPRRF TH_4458|M.thermoresistible__bu -------------QLLNGPSVSDLAEWIST-------------------- . : MUL_1655|M.ulcerans_Agy99 ---------------------------QLSGGNHEESDDDKIWSVLRT-- MMAR_2473|M.marinum_M ---------------------------QLSGGNHEESDDDKIWSVLRT-- Mb1692|M.bovis_AF2122/97 ---------------------------QLLGGQHESSDDESIWQLLKN-- Rv1664|M.tuberculosis_H37Rv ---------------------------QLLGGQHESSDDESIWQLLKN-- MAV_3107|M.avium_104 ---------------------------QLLHDEDPESDDERIWSALRR-- MLBr_00135|M.leprae_Br4923 --------TVRSLVTRAMTAEQLRTAVTAAGGALEQGPMDLVWSPIPLSS MAB_0939|M.abscessus_ATCC_1997 YCRARWHESPLDSETQVFDLDYLDRDGRHLGGIREFTVKRAPREALLRGL Mvan_0269|M.vanbaalenii_PYR-1 YCRATWHTSELDSETQVFDLDFLDRDGRHLGGIREFTVKRAPREALLRGL Mflv_0405|M.gilvum_PYR-GCK YCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVREFTVKRAPREALLRGL MSMEG_0408|M.smegmatis_MC2_155 YCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTVKRAPREALLRGL TH_4458|M.thermoresistible__bu ----------------------------TMVGFGSTTPEPESAGVPGR-- . MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 DGHGGGLPSVVSWADYCAGRGN---------------------------- MAB_0939|M.abscessus_ATCC_1997 GGDATRLLYTLGWHEVAVPPVAGEGEESAASIGTWLIAGFDELAAKVPGC Mvan_0269|M.vanbaalenii_PYR-1 GGDATRLLYTLGWHEVPAPASG-----DAALNGNWLIAGFDELAAGVPGC Mflv_0405|M.gilvum_PYR-GCK GGDATRLLYTLGWHEVPVPESG----DGAAPQGTWLIGGFDELAVSVPGC MSMEG_0408|M.smegmatis_MC2_155 GGDATRLLYTLGWHEVPPPPSA------DDAVGTWLIAGFDELAAKVPGC TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 ----------------------------IPVRELRRS------------- MMAR_2473|M.marinum_M ----------------------------IPVRELRRS------------- Mb1692|M.bovis_AF2122/97 ----------------------------IPIHQLRRT------------- Rv1664|M.tuberculosis_H37Rv ----------------------------IPIHQLRRT------------- MAV_3107|M.avium_104 ----------------------------IPLRELRRT------------- MLBr_00135|M.leprae_Br4923 -------------------------DTGVVVWEFGSASAGAQAPVDSVAA MAB_0939|M.abscessus_ATCC_1997 IPLNRETDPELLGEVLVAAKERGVPFSGVVWRAAGPGATES--TTESAAR Mvan_0269|M.vanbaalenii_PYR-1 IPFDRSTDPEPLGQLLAQAHERGIGFSGVVWRAAAPSADES--STAMAAR Mflv_0405|M.gilvum_PYR-GCK IPADR-TNPESLRQLLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAAR MSMEG_0408|M.smegmatis_MC2_155 VPIDRNTDLQVLGEVLSQAHARGAGFSGVVWRCATPGRKESGSASAESAR TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 ------GMLDKLLLLAG-----QDER------PAPDAAVSDDVIDSLSPE MMAR_2473|M.marinum_M ------GMLDKLLLLAG-----QDES------PAPDAAVSDDVIDSLSPE Mb1692|M.bovis_AF2122/97 ------GLLDKLLLLAG-----QPEE------SLAGRTVSDEVIDSLSPE Rv1664|M.tuberculosis_H37Rv ------GLLDKLLLLAG-----QPEE------SLAGRTVSDEVIDSLSPE MAV_3107|M.avium_104 ------GLLDKLLLLAG-----MPET------ATTDAKISDADIDSLSPD MLBr_00135|M.leprae_Br4923 VYSATHAALQVLQFWFG-----QDRAGTLVVLTRGAVGLVGEGISDLAAA MAB_0939|M.abscessus_ATCC_1997 LEGEIAHLLSAVHTVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQA Mvan_0269|M.vanbaalenii_PYR-1 IETEIADLLSAVHTVQN---GAVKLPGGLWIVTERAVATESGEPVDPVQA Mflv_0405|M.gilvum_PYR-GCK LEAEIAELLGAVHTVQG---GEVKLPGGLWIVTERAVATESGEPVDPVQA MSMEG_0408|M.smegmatis_MC2_155 LEAEITNLLSAVHAAQG---PSVKLPGGLWIVTEHGVACESGEPVDPVQA TH_4458|M.thermoresistible__bu ------SRPPDGAVASG------SGDGGRWIELLNQMPEVSDDTVDELLR . . . MUL_1655|M.ulcerans_Agy99 ALVAMALDSEDDDPD----------------------------------- MMAR_2473|M.marinum_M ALVAMALDSEDDDPD----------------------------------- Mb1692|M.bovis_AF2122/97 ALIGLALDEDENDIR----------------------------------- Rv1664|M.tuberculosis_H37Rv ALIGLALDEDENDIR----------------------------------- MAV_3107|M.avium_104 ALIAMALNSADDDEAE---------------------------------- MLBr_00135|M.leprae_Br4923 AVWGMVRSAQSEHSGKIVLID--------TDSAVDVAVLADLGESQLLVR MAB_0939|M.abscessus_ATCC_1997 ALWGFGRTTINEEPALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVR Mvan_0269|M.vanbaalenii_PYR-1 ALWGFGRTTINEEPALRCRLVDVDGSPEAVLALAGLLAAP-VDEPELAVR Mflv_0405|M.gilvum_PYR-GCK ALWGFGRTAINEEPALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVR MSMEG_0408|M.smegmatis_MC2_155 ALWGFGRTTINEEPALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVR TH_4458|M.thermoresistible__bu QLLAAGENHDDTQLH----------------------------------- : . . . MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 CNTVHAARLSPAPQLLALPVGESMWRLAADGGGTLEDLVIQPCPEVQAPL MAB_0939|M.abscessus_ATCC_1997 QGKLLASRLLPWSRTGHLTVPRGSDYVLAPTERGAIDNLRITEKEVPAP- Mvan_0269|M.vanbaalenii_PYR-1 QGKLLASRLLPWARSGHLTVPRSADYVLAPTERGAIDNLRLTETDVAPP- Mflv_0405|M.gilvum_PYR-GCK QGKLLASRLLPWSRSGHLTVPRGGDYVLAPTERGAIDNLRLTDSEVPPP- MSMEG_0408|M.smegmatis_MC2_155 QGKLLASRLLPWARSGHLTLPRGGDFVLAPTERGAIDNLRLTETDVPEP- TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 QAGHMRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVIEIGPEVTG MAB_0939|M.abscessus_ATCC_1997 DEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTG Mvan_0269|M.vanbaalenii_PYR-1 AEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGSGVTG Mflv_0405|M.gilvum_PYR-GCK AEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTG MSMEG_0408|M.smegmatis_MC2_155 DEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSG TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 VAVGDAVMGFLGGAGPLAV-VHQQLITQMPQGWSLAEAAAVPVVFLTALF MAB_0939|M.abscessus_ATCC_1997 VEVGQRVYGSMQGAFGSRFNVPAQFLAPIPDGISGVEAATIPAAALTVR- Mvan_0269|M.vanbaalenii_PYR-1 LEVGQRVYGFMQGAFASRFNVPAQLLAPIPDGIGAVDAATIPAAALTAR- Mflv_0405|M.gilvum_PYR-GCK LDVGQRVYGSMQGAFASRFNVPGQFLAPIPDGVSAVEAATIPAAALTVR- MSMEG_0408|M.smegmatis_MC2_155 LEIGQRVYGSMQGAFASRFNVPAQFLAPIPDGIGAVEAATIPAAALTVR- TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 GLADLAGIRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTASRGKWDTL MAB_0939|M.abscessus_ATCC_1997 LSFDWAQLKPGDKVLIHAASGGVGLAAIQMAQQFGAEVFATASTFKRATL Mvan_0269|M.vanbaalenii_PYR-1 LAFDWAQLKPGDRVLIHAASGGVGLAAIQMAQQHGAVVFATASTYKRATL Mflv_0405|M.gilvum_PYR-GCK LSFDWAQVKSGDKVLIHAASGGVGLAAVQMAQQCGAEVYATASTFKRATL MSMEG_0408|M.smegmatis_MC2_155 LAFDWAQLKPGDKVLIHAASGGVGLAAIQMAQQSGAEVFATASTFKRSTL TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 RDMGFDDDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRL MAB_0939|M.abscessus_ATCC_1997 RKLG--VKYVYDSRTTDFADQILADTDGAGVDVVLNSLTSEGFIEATLRA Mvan_0269|M.vanbaalenii_PYR-1 RKLG--VDHVYDSRTTEFADQILADTDGEGVDVVLNSLTNEGFIEATVRA Mflv_0405|M.gilvum_PYR-GCK RKLG--VKHVYDSRTTDFAEQILADTDGAGVDVVLNSLTSEGFIEATLRA MSMEG_0408|M.smegmatis_MC2_155 RRLG--VKYVYDSRTTDFADQILADTNGAGVDVVLNSLTSAGFVEATLKA TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 LVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLS---EAGPVRMQEML MAB_0939|M.abscessus_ATCC_1997 TAKNGRFAEIAKRDIWTTEQMAQSRPDIAYEIVALDTVMFQEPDRIRVLL Mvan_0269|M.vanbaalenii_PYR-1 TAQNGRFAEIAKRDIWTPEQMAAARPDIAYEIVALDTVTLLEPERIRGLL Mflv_0405|M.gilvum_PYR-GCK TAQHGRFAEIAKRDIWTVEQMAAARPDLAYEIVALDTVMFTEPDRIRDLL MSMEG_0408|M.smegmatis_MC2_155 TAQGGRFAEIAKRDIWSHEQMAEARPDIAYEIVALDTVMFTEPDRIRDLL TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 CEVRELFDTQ------VLHRLPVTSWDVRCAPAAFRFMSQARHIGKVVLT MAB_0939|M.abscessus_ATCC_1997 TEVSEGLAKG------EWTPLPAEIYPLTEARTAFRRMQQARHIGKIVCQ Mvan_0269|M.vanbaalenii_PYR-1 GEVSDGLGKADGSSRAEWVPLPAEIYPLTEARAAFRRMQQARHVGKIVLQ Mflv_0405|M.gilvum_PYR-GCK TEVSAGLRDG------AWTPLPAEVYPLTEARAAFRRMQQARHIGKIVVQ MSMEG_0408|M.smegmatis_MC2_155 TEVSDGMARG------EWTPLPAEIYPITEARSAFRRMQQARHIGKIVLQ TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 MPSALADGLAEGTVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDRA MAB_0939|M.abscessus_ATCC_1997 MPNPLAP-RPDRTYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRAPDT Mvan_0269|M.vanbaalenii_PYR-1 MPKPLQP-RADRSYLITGGLGAIG-LHTAAYLAQLGAGDLVLTSRRAPDA Mflv_0405|M.gilvum_PYR-GCK IPNPLQP-QPDRSYLITGGLGAIG-LHTAGYLAQLGAGDIVLTSRRAPDA MSMEG_0408|M.smegmatis_MC2_155 VPKPLQP-QQDRSYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRDPDE TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 EGAVELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHA MAB_0939|M.abscessus_ATCC_1997 DAQRVIGEITERSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAHL Mvan_0269|M.vanbaalenii_PYR-1 DARRAIEEITERYKCRVHTFCADVGDESQVAELLARIRAELPPLAGVAHL Mflv_0405|M.gilvum_PYR-GCK AAQQAIADIADRTKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHL MSMEG_0408|M.smegmatis_MC2_155 SAQRAIDEITERHKCRIHTYAADVGDEAQVADLLARIRAELPPLAGIAHL TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 AGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIA MAB_0939|M.abscessus_ATCC_1997 AGVLDDALLGQQSVERFRTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVS Mvan_0269|M.vanbaalenii_PYR-1 AGVLDDALLSQQSLERFRTTLAPKAFGACHLDRLTAGDDLDFFIMSSSVS Mflv_0405|M.gilvum_PYR-GCK AGVLDDALLSQQSVERFRTALAPKAFGAVHLDRLTRVDDLDFFLVSSSVS MSMEG_0408|M.smegmatis_MC2_155 AGVLDDALLSAQNPERFRTTLAPKAYGASHLDRLTRDDDLDFFIVSSSVS TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ATVGSPGQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHL MAB_0939|M.abscessus_ATCC_1997 SLFGSPGQSNYATANALLDGLIAQRRAQGLPATGINFGPWGQGGMASSEA Mvan_0269|M.vanbaalenii_PYR-1 SLFGSPGQANYATANALLDGLTAHRRARGLPATGVNFGPWAQGGMASSEA Mflv_0405|M.gilvum_PYR-GCK SLFGSPGQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEA MSMEG_0408|M.smegmatis_MC2_155 SLFGSPGQANYATANAMLDGLVAKRRAQGLVATGINFGPWGQGGMASSEA TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 SSRDLARISRSGLAPMNPAQALELFDAALVIDHPFMVTALLDRAALDAQA MAB_0939|M.abscessus_ATCC_1997 ATAN---ISAQGLIPLDPSAALAALAEVVANGTG-QATILKANWQRAAKV Mvan_0269|M.vanbaalenii_PYR-1 ATAN---IGAQGLVPLEPSAALGALAEVLANGTG-QAAVLKANWQRAAKV Mflv_0405|M.gilvum_PYR-GCK AAAN---ISAQGLIPLEPSAALTAMAEVVANGTA-QATVLKANWQRAAKV MSMEG_0408|M.smegmatis_MC2_155 ATAN---ITAQGLIPLDPSAALHALAEVIANGSG-QATVLKANWQRAAKV TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 QAGALPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQGLAANRQLELL MAB_0939|M.abscessus_ATCC_1997 LGSSRPPILDLVLPSAVGEVTGDSELLKQLMEIPVPQRAGFVTEFLQREV Mvan_0269|M.vanbaalenii_PYR-1 LGSSRPPILDLVLPRPEGEVAGDSELLRQLQEIPVAQRAGFVTEFLQREV Mflv_0405|M.gilvum_PYR-GCK LGSSRPPILDLVLPSAVGEITGDSELLKQLQEIPVPQRAGFVTEFLQKEV MSMEG_0408|M.smegmatis_MC2_155 LGSARPPILDLVLPSAAGEATGDSELLKQLMEIPIPQRAGFVTEFLQREV TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 VGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATG-- MAB_0939|M.abscessus_ATCC_1997 QNFLRLAQPP----------AATSRFLDLGTDSLMAIELRNRLHSQFGGK Mvan_0269|M.vanbaalenii_PYR-1 QNFLRLAQPP----------AATSRFLDLGTDSLMAIELRNRLHSQFGGA Mflv_0405|M.gilvum_PYR-GCK QNFLRLAQPP----------AATSRFLDLGTDSLMAIELRNRLHSQFGGA MSMEG_0408|M.smegmatis_MC2_155 QNFLRLASPP----------AASSRFLDLGTDSLMAIELRNRLHSQFGGK TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2473|M.marinum_M -------------------------------------------------- Mb1692|M.bovis_AF2122/97 -------------------------------------------------- Rv1664|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 LTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVSV MAB_0939|M.abscessus_ATCC_1997 FTINATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAVESAEAESGAGP Mvan_0269|M.vanbaalenii_PYR-1 FTINATAVFDYPTIGGLAEYLVGQLPDSDAAAGETPATETSPIDHNHPDR Mflv_0405|M.gilvum_PYR-GCK FTINATAVFDYPTIGGLAEYLVAQLPD-----AETPQAAPQSESEPGPDV MSMEG_0408|M.smegmatis_MC2_155 FTINATAVFDYPTIGGLAEYLVGQLPD-----AEAPETA----------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MUL_1655|M.ulcerans_Agy99 ------------ MMAR_2473|M.marinum_M ------------ Mb1692|M.bovis_AF2122/97 ------------ Rv1664|M.tuberculosis_H37Rv ------------ MAV_3107|M.avium_104 ------------ MLBr_00135|M.leprae_Br4923 HA---------- MAB_0939|M.abscessus_ATCC_1997 AAASDAVSELKE Mvan_0269|M.vanbaalenii_PYR-1 EADSPG------ Mflv_0405|M.gilvum_PYR-GCK TE---------- MSMEG_0408|M.smegmatis_MC2_155 ------------ TH_4458|M.thermoresistible__bu ------------