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MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAASEVEELLGVVASEGWQGQAAEAFVAA YMPFLAWLIQASADCVEMAAQQHVVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINEA EYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSDELLPDTGEDSDEDGHNHGGHSHGGHARMID NFFAEILRGVSAGRIVWDPVNGTLNGLDYDDYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFL LYVVVVDLPTHIAQIATWLGQYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPSAAIPAVVPELTPVAAA PPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAAGPTPPATGFGGFPPYLVGGGGPGIGFGSGQSAHAK AAASDSAAAESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQPGARASDCGAGPI GFAGTVRKEAVVKAAGLTTLAGDDFGGGPTMPMMPGTWTHDQGVFDEHR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1387 | PPE20 | - | 100% (539) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0453 | PPE11 | e-139 | 50.37% (534) | PPE family protein |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | e-138 | 51.48% (540) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1422 | PPE20 | 0.0 | 99.81% (539) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-75 | 37.07% (553) | PPE protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 0.0 | 69.49% (544) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-84 | 40.33% (538) | PPE family protein |
| M. marinum M | MMAR_1418 | - | 1e-134 | 49.35% (541) | PPE family protein |
| M. avium 104 | MAV_4879 | - | 1e-120 | 46.62% (547) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-77 | 39.27% (545) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-56 | 33.09% (559) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-134 | 49.81% (530) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-79 | 37.41% (556) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
Rv1387|M.tuberculosis_H37Rv -----------MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQ
Mb1422|M.bovis_AF2122/97 -----------MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQ
MLBr_00539|M.leprae_Br4923 -----------MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
MMAR_1418|M.marinum_M ----------MTAPIWMASPPEVHSALLSSGPGPGPLLSAAAAWSQLSNE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MAV_4879|M.avium_104 ----------MTAPIFMASPPELHSALLSSGPGPASLLAAAGAWSQLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
:: ***::*::* *.* ..: .. *. .
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
Rv1387|M.tuberculosis_H37Rv YAEAASEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMA
Mb1422|M.bovis_AF2122/97 YAEAASEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
MMAR_1418|M.marinum_M YASAANELTAMLGAVQAGPWEGSSAEQYVAAHLPYVAWLMQASVDTTQAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MAV_4879|M.avium_104 YASAAEQLSTLLTGVAAGAWQGVSGESYVGAHAPYLAWLTKASADSAAVA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* .* :: :: . . *.* . : :..: *:: ** : .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
Rv1387|M.tuberculosis_H37Rv AQQHVVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINE
Mb1422|M.bovis_AF2122/97 AQQHAVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
MMAR_1418|M.marinum_M AQLETAAAAYTTALAAMPTLPELATNHTIHAALTATNFFGINTIPITLNE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MAV_4879|M.avium_104 AQHEVAATAYTTALATMPTLPELAANHAVHATLVATNFFGVNTVPIAVNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.* .. *:::*: *** **: *: ..* .***:*:**:** .*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVG-------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVG-------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVG-------
Rv1387|M.tuberculosis_H37Rv AEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSDELLPDTGED
Mb1422|M.bovis_AF2122/97 AEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSDELLPDTGED
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKD
MMAR_1418|M.marinum_M ADYVRMWIQAATTMSTYQAVSGTALASTPQTAPAPYILKSNAQTEDS---
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAAHDH---
MAV_4879|M.avium_104 ADYARMWTQAATTMSTYHAVSTAAVASTPQAEPAPQIVKSDASQDDSG--
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHDHGHDD---
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESAT---
:*..** :*****:** : : *::: * : ..* ::
Mflv_0325|M.gilvum_PYR-GCK -----------EAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYG
Mvan_0415|M.vanbaalenii_PYR-1 -----------EAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYG
MSMEG_0619|M.smegmatis_MC2_155 -----------EAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYL
Rv1387|M.tuberculosis_H37Rv SDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLDY
Mb1422|M.bovis_AF2122/97 SDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLDY
MLBr_00539|M.leprae_Br4923 S-----RHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDY
MMAR_1418|M.marinum_M ---------QPPVEGS-DPLDSLVADILRAITDGRVNWDPVSRTVNGIEY
MUL_1202|M.ulcerans_Agy99 ---------DHDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPY
MAV_4879|M.avium_104 --------NEDHDPKIDNPFNDFIANILRNLG---IDWDPAKGTVNGLDY
MAB_0809c|M.abscessus_ATCC_199 ---------HDHEHGHDDDHG--------------------HGDLD----
TH_3113|M.thermoresistible__bu ----------AAITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGF
:
Mflv_0325|M.gilvum_PYR-GCK EVLR---FLFEPIFNFLR--DPIGNTFALITDFLTNPVQALITWGPFLLA
Mvan_0415|M.vanbaalenii_PYR-1 ELLR---FLFEPIFDFLR--DPLGNTIKLITDFLTNPAQALITWGPFLAA
MSMEG_0619|M.smegmatis_MC2_155 QGVP---GG-QAILDFLK--DPLGNLGRLLTDFMTNPAGALATWWPFLFG
Rv1387|M.tuberculosis_H37Rv DDYV---YPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFLLYVVVV
Mb1422|M.bovis_AF2122/97 DDYV---YPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFLLYVVVV
MLBr_00539|M.leprae_Br4923 DDYV---YPGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVL
MMAR_1418|M.marinum_M EEYT---DAGDPVWWVVRALEFSQDFRTFARLLPTDPQAALQFYGELFLF
MUL_1202|M.ulcerans_Agy99 DDYV---NAAQPIWWLVRALEFGQDFQTFIKELFTNPIGAIEFMVELVLF
MAV_4879|M.avium_104 DAYT---NAGEPIFWVVRALELLEDFEQFGYYLVHNPALAFQYLVQLMLF
MAB_0809c|M.abscessus_ATCC_199 --------PTDPEWWVHVAGEMVEHFELLLNNLLTDP-AALLTNLPMVLA
TH_3113|M.thermoresistible__bu ADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVY
. : ..
Mflv_0325|M.gilvum_PYR-GCK VVYQA----VSWVGAS-ILYPSLFLLPLLATT--LAIVAGVGQHLLSLLN
Mvan_0415|M.vanbaalenii_PYR-1 VAYQA----VSWVGAS-ILYPSLLLLPLVATT--LAIVLGVGAYLLENLP
MSMEG_0619|M.smegmatis_MC2_155 VAYQVFFNLVGWPTWG-MIFASPFLIPALAALGITGLVLLIDHVLNNPVD
Rv1387|M.tuberculosis_H37Rv DLPTHIAQIATWLGQY-PQLLSAALTGVIAHLGAITGLAGLS-GLSAIPS
Mb1422|M.bovis_AF2122/97 DLPTHIAQIATWLGQY-PQLLSAALTGVIAHLGAITGLAGLS-GLSAIPS
MLBr_00539|M.leprae_Br4923 DLPTHIVQLGTWLAEY-PQLLLVALGGTIANLGAVTGLAGLSSGLSAGPS
MMAR_1418|M.marinum_M DYPVHIPQLLTWLSQS-PQLLAVALGQAVSGLGAVTGFAGLA-GLAAQPI
MUL_1202|M.ulcerans_Agy99 DWPTHIAQIIQALAQS-PQLLAVALGGVVANLGAISGLAGLS-GLAGLHS
MAV_4879|M.avium_104 DWPTHILEIFMSQ----PELLAPALLLAAAPFAAVGGFAGLA-GLAALPQ
MAB_0809c|M.abscessus_ATCC_199 DVAFHAAQLASTIGQFAPALIQPALALAIANLGWAAGFAGLA-GIQPSPE
TH_3113|M.thermoresistible__bu LLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAG
. : :
Mflv_0325|M.gilvum_PYR-GCK TPPAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGS
Mvan_0415|M.vanbaalenii_PYR-1 APAEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGT
MSMEG_0619|M.smegmatis_MC2_155 VPAEDEAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPA
Rv1387|M.tuberculosis_H37Rv -AAIPAVVPELTPVAAAPPMLAVAGVG-PAVAAPGMLPASAPAPAAAAGA
Mb1422|M.bovis_AF2122/97 -AAIPAVVPELTPVAAAPPMLAVAGVG-PAVAAPGMLPASAPAPAAAAGA
MLBr_00539|M.leprae_Br4923 -AAIPTVVPESAPIATVPAMLAGAGVA-PAVVAPGASPSSAAPPASAASA
MMAR_1418|M.marinum_M -GTVASALGPVAAPADMLPVTSMAPT--VTTPVAAPVSATAPAPATALTA
MUL_1202|M.ulcerans_Agy99 -AALPAAIAPIAPP--MPPGVALAPT--VAASVAAPTPPSAPPSAASTVA
MAV_4879|M.avium_104 PVAVPAAVAAPPAPPGLPPAIAIAPTPVAAAAPVATAPAPAPAATATTVA
MAB_0809c|M.abscessus_ATCC_199 ILAVEPGSVEDAPMA-ASAGTALAPSP-PASAAAPAAPASAPAPTASGTA
TH_3113|M.thermoresistible__bu LAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGG
.. . .
Mflv_0325|M.gilvum_PYR-GCK PPAPGAP--AAAAATFVPYVVAGRDPYEGFSPTVRDSTG----AKAPAGT
Mvan_0415|M.vanbaalenii_PYR-1 APAPGAP--AAATASFVPYAVAGRDPGTGFSPTVRDSTS----AKAPASG
MSMEG_0619|M.smegmatis_MC2_155 GTTVAAP--APAAATFVPYAVANRDPGEGFTPTLGNKSQ----VAAPASG
Rv1387|M.tuberculosis_H37Rv TAAGPTP-PATGFGGFPPYLVGGGGPGIGFGSG-QSAHA---KAAASDSA
Mb1422|M.bovis_AF2122/97 TAAGPTP-PATGFGGFPPYLVGGGGPGIGFGSG-QSAHA---KAAASDSA
MLBr_00539|M.leprae_Br4923 AAAAPAP-PGTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVSESVSDSA
MMAR_1418|M.marinum_M GGPPPVP-PAAGGAGFSYPYLIGGGPSIGFGSGMSTSASASAKKKTPEPD
MUL_1202|M.ulcerans_Agy99 NAAPPPP-PAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPD
MAV_4879|M.avium_104 GAPPAAPAPVAPAAGFFPPYVIGP-PGMGTGSGMSASASSSAKRKAPEPD
MAB_0809c|M.abscessus_ATCC_199 PAPPSPP--PVGDPGFSFPYAVGGGPRLGTGLALAAQVRR--GTSAAARS
TH_3113|M.thermoresistible__bu AGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVAR---RSAGARR
. . . * .
Mflv_0325|M.gilvum_PYR-GCK IPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQP
Mvan_0415|M.vanbaalenii_PYR-1 IPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQ
MSMEG_0619|M.smegmatis_MC2_155 VPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQP
Rv1387|M.tuberculosis_H37Rv AAESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQ
Mb1422|M.bovis_AF2122/97 AAESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQ
MLBr_00539|M.leprae_Br4923 VAEAAAQASAREQARAWRR-RSAAKERGYREEVITMNTGFDAAIPSPVDQ
MMAR_1418|M.marinum_M ---TAAAAAARERARARRRRRATLR--GYGDEFMDI--EVDPDWGAPPGE
MUL_1202|M.ulcerans_Agy99 SAALAAAAAVREEARRRRRKRKTER--GYGEEFMDV--EVDPDWGGPLDD
MAV_4879|M.avium_104 SAAAAAAAAARAAARSRRRRRATRH--GHGEEFMDMNVDVDPDWGGPAGP
MAB_0809c|M.abscessus_ATCC_199 SAREQAAAAETAAARQARRRRDKGKQQGRGIEYMDMN--ATARCEEPAPD
TH_3113|M.thermoresistible__bu AASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAAT
. *. . .
Mflv_0325|M.gilvum_PYR-GCK AP--RVTASTRGAGPMGFAGTVSRGDEQ-AGGLTTLA-GDSFGGGPREPM
Mvan_0415|M.vanbaalenii_PYR-1 EP--RIAATERGAGPMGFAGTVSRDAAQ-AGGLTTLP-GDPFGGGPKAPM
MSMEG_0619|M.smegmatis_MC2_155 EP--RVRASERGSDAMGFTGTVTRHDVT-AAGLTTLT-GDTFDDRPVTPM
Rv1387|M.tuberculosis_H37Rv PG---ARASDCGAGPIGFAGTVRKEAVVKAAGLTTLA-GDDFGGGPTMPM
Mb1422|M.bovis_AF2122/97 PG---ARASDCGAGPIGFAGTVRKEAVVKAAGLTTLA-GDDFGGGPTMPM
MLBr_00539|M.leprae_Br4923 TG---SRVSDCGAGSFGFAGTVSKEAVVEVAGLTTLA-GDDFGGGPTMPM
MMAR_1418|M.marinum_M GPGASTVASDHGAGPVGIAGTVHTGSVTPAAGLTTLG-GDDFDGEPRMPM
MUL_1202|M.ulcerans_Agy99 EP----VASTQGAGRLGFAGTVHSESAATAAGLTTLV-ADEFGGGPKMPM
MAV_4879|M.avium_104 ES----SASDRGAGALGFAGTARKDAAGAAAGLTTLP-GAELGG-PTMPM
MAB_0809c|M.abscessus_ATCC_199 TT-----ASHRGAGTMGFAGTVIKTGAT-ASGLAMLSRDDDLFEGVRAPM
TH_3113|M.thermoresistible__bu AP------SAAGIRVLGGAGRISRTRGSVPHAEITPG-------DPTEPS
: * .* :* . *
Mflv_0325|M.gilvum_PYR-GCK LPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 LPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 LPGTWDGDENPAP------SPDDPEGGPRR
Rv1387|M.tuberculosis_H37Rv MPGTWTHD------------QGVFDEHR--
Mb1422|M.bovis_AF2122/97 MPGTWTHD------------QGVFDEHR--
MLBr_00539|M.leprae_Br4923 VPGTWAPA------------RESSDEGR--
MMAR_1418|M.marinum_M LPGTWDPD------------GARDAGKGS-
MUL_1202|M.ulcerans_Agy99 LPGTWDTD------------SDAPSD----
MAV_4879|M.avium_104 MPGSWEPG------------DDAGAEHDS-
MAB_0809c|M.abscessus_ATCC_199 VPNTWDPE------------HGRQD-----
TH_3113|M.thermoresistible__bu SPTDRAHR------------PAEPN-----
*